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Sequences

Sequence NM_133454

CACCGCCTCCTGGGACTCGGAACGCAGCGCTCGGAGCCATGGCCTCGGCCCCCGCGGAGGCGGAGACCCGACAGAGGCTGCTACGCACCGTCAAGAAGGA GGTGAAGCAGATCATGGAGGAGGCTGTGACACGCAAGTTTGTCCACGAAGACAGCAGCCACATCATCTCCTTCTGTGCGGCTGTGGAGGCCTGCGTTCTG CACGGGCTTCGGCGGCGGGCGGCTGGCTTCCTACGCAGCAATAAGATTGCAGCCCTCTTTATGAAAGTGGGCAAGAACTTCCCGCCGGCTGAGGATCTGA GCCGCAAGGTGCAAGACCTGGAGCAGCTGATCGAGAGCGCGAGAAACCAGATTCAAGGCCTCCAGGAGAATGTGCGGAAGCTGCCGAAGCTGCCCAACTT GTCCCCACTTGCCATCAAGCATCTGTGGATTCGCACAGCCTTGTTTGAGAAGGTCCTGGACAAAATTGTGCATTACCTTGTGGAAAACAGCAGTAAATAC TATGAGAAGGAAGCTCTCCTGATGGACCCTGTGGACGGCCCCATCCTTGCATCTTTGTTGGTGGGGCCCTGTGCCCTAGAGTACACCAAGATGAAGACTG CAGATCACTTCTGGACCGATCCCTCGGCTGACGAACTTGTCCAGAGGCACCGCATCCACAGCTCCCACGTGCGGCAGGACTCGCCCACCAAGCGTCCTGC CCTCTGTATCCAGAAGAGGCATTCCAGTGGCAGCATGGATGACCGGCCATCCCTCTCTGCCCGCGACTACGTGGAGTCCCTGCATCAGAACTCCCGTGCC ACCCTTCTCTATGGCAAAAACAACGTTCTTGTTCAGCCGAGGGACGACATGGAGGCTGTGCCAGGGTACCTGTCCCTGCACCAGACGGCTGACGTCATGA CCTTGAAGTGGACACCCAACCAGCTGATGAACGGGTCTGTGGGGGACCTGGACTATGAGAAGAGCGTCTACTGGGACTATGCCATGACCATCCGCTTGGA GGAGATTGTCTACCTGCACTGCCACCAGCAAGTTGACAGCGGCGGGACAGTGGTATTGGTCAGCCAGGACGGGATCCAGAGGCCGCCCTTCCGCTTCCCC AAGGGCGGGCACCTCCTGCAGTTCCTCTCGTGCCTGGAGAATGGGCTGCTCCCACATGGGCAGTTGGACCCGCCACTGTGGTCCCAGAGGGGTAAGGGCA AAGTGTTTCCTAAACTGCGCAAGCGAAGCCCTCAGGGTTCTGCCGAGTCCACATCTTCAGACAAAGATGATGATGAGGCCACGGATTATGTGTTCAGGAT CATCTACCCTGGCATGCAGTCGGAATTCGTTGCCCCCGACTTCTTGGGCAGCACTTCCTCCGTCTCTGTGGGCCCTGCCTGGATGATGGTTCCTGCAGGC CGGTCCATGCTGGTGGTGGCCAGAGGGAGTCAGTGGGAGCCAGCCAGATGGGACACTACTCTCCCCACGCCAAGCCCGAAGGAGCAGCCCCCCATGCCCC AGGATCTGATGGACGTCTCTGTAAGCAACCTCCCATCCCTGTGGCAGCCCAGTCCCCGGAAGTCCTCCTGTTCATCCTGTTCACAGAGTGGCTCGGCTGA TGGTAGCTCGACCAATGGCTGCAACCATGAGAGGGCTCCCCTGAAACTTCTCTGTGACAATATGAAGTACCAGATCCTCTCCAGAGCCTTCTATGGATGG CTGGCCTACTGCAGACACCTGTCCACCGTGAGAACCCACCTATCAGCCCTGGTCAATCACATGATCGTGTCTCCAGACTTGCCCTGCGATGCTGGACAGG GACTGACAGCCAGGATCTGGGAGCAGTACCTTCACGACAGCACAAGTTACGAGGAGCAGGAGCTGCTGCGCCTCATCTACTACGGGGGCATCCAGCCTGA GATCCGCAAGGCCGTGTGGCCCTTCCTCCTGGGCCACTACCAGTTCGGGATGACGGAAACAGAAAGGAAAGAGTCCTCCCAGAGCTGCAGTTCGGGCCGC CAGAACATCCGCCTGCACAGCGACTCCAGCAGCAGCACACAGGTGTTTGAGTCTGTGGATGAGGTGGAGCAGGTGGAGGCTGAAGGCAGATTGGAGGAGA AACAGCCCAAGATCCCCAATGGGAACCTAGTGAACGGCACTTGTTCCCCAGACTCGGGTCATCCTTCCTCCCATAACTTCTCCTCGGGCCTCTCAGAGCA CTCAGAGCCCAGTCTGAGCACAGAAGACAGTGTCTTGGACGCCCAGCGGAACACCCCCACGGTGCTGCGACCTAGGGATGGCAGCGTGGATGACAGGCAG AGCAGCGAGGCCACCACATCTCAGGATGAGGCTCCCCGGGAGGAGCTGGCCGTGCAGGACAGCCTGGAGAGTGACCTCCTGGCCAACGAGAGCATGGACG AGTTCATGTCCATCACGGGCAGCCTGGACATGGCCCTGCCTGAAAAGGACGATGTTGTGATGGAGGGCTGGAGGAGCAGCGAGACAGAGAAACATGGCCA GGCGGACAGTGAGGACAACCTCTCGGAGGAGCCTGAGATGGAAAGTCTCTTCCCTGCCCTGGCTTCTCTGGCTGTGACTACTTCTGCCAACGAGGTGTCC CCTGTGTCTTCCAGCGGCGTCACCTACTCTCCAGAGCTGCTGGATCTGTACACGGTGAACCTGCACCGCATCGAGAAGGATGTGCAGAGGTGCGACCGCA ACTACTGGTACTTCACGCCCGCCAACTTGGAGAAGCTGCGTAACATCATGTGCAGCTACATCTGGCAGCACATTGAGATCGGCTATGTCCAGGGCATGTG TGATCTTCTGGCTCCACTGCTGGTCATTCTGGATGATGAGGCCCTTGCCTTCAGCTGCTTCACGGAGCTCATGAAGAGGATGAACCAGAACTTCCCCCAC GGAGGCGCCATGGACACGCACTTTGCAAACATGAGATCGTTGATCCAGATCCTGGACTCAGAGCTGTTTGAGCTGATGCATCAGAACGGGGACTATACTC ACTTCTACTTCTGCTACCGCTGGTTCCTGCTGGATTTCAAGCGAGAACTCGTCTATGATGACGTCTTCTTGGTCTGGGAGACCATCTGGGCAGCCAAACA CGTCTCCTCTGCGCACTACGTCCTGTTCATTGCGCTGGCTCTGGTGGAAGTCTACCGTGACATCATTTTGGAGAACAACATGGATTTCACAGACATCATC AAATTCTTTAATGAAATGGCTGAGCGACACAACACCAAGCAAGTCCTGAAGCTGGCGCGGGACCTCGTGTACAAGGTGCAGACTCTGATTGAGAACAAGT GAGGGGCACCTCACCCCGGCAGCCTCAGCCAAGCTGCCCCTGCCCCGCTCCTCTGCTTACTTTTCCTCCTGGCTGGATGGGCACCCCGGGAGCGGGGTCC TGGTGTCTGTTCACAAGCGTGGAGTTCAGTGCGCAAAGAAACTACCCTGACTTTTACTTCTGGGCAGATGGGGTGGAGGGAGTACCCCTTCAATTCAGCC TTACATTTTCCTGTTTGACCAAAGATTGCCCAAGTCTGGCGTTCCTCCCTTGCAGGAGGTGGAGGTTGTTGGTGGAGGAGGAGCCATCTTTGTTTGCTGG TGCCCGGAATGGTCTCCTCTTCTTCTTTCCCTATCCCTCCAAACTGTCTTGTAAGATGAGACCTGGGGAGGAAACTTCTTTTTGGAAATTGGTGTAGAAG AGGTGTGTGGGGCTACCTCTATGCTCCTCTGCAAGGGGCCTTTGGCGATGTTCTGGACATGGCTGAAGATTGACTTAGAGATTGACCCTCCACCTCGACA TTACTGACATTTGGGGCCAGGTGATTCTTTTTGAGGGGACTGTCCCCTGCATTGTAGGATGCTGAGCAGCATCCCGGGCCTCACCAGATGCCAGTAGTGC CATCCCCCAACCATACCCCTGGTTGTGACAGCCCCCAAAAATGTCTCTAGACATTGCGAAATGTTCCCTGCAGGGCAAAATTGCCCCCATTTGAGAACCA CTGGCTTGGAGAAGGGACTACAAATGTACTTCCTCCCCCATTCTTTTGACGCTAAGCCACCCTGGTCCTGACGCCTCCCCTCACTTAGAAAAGGCATACA GGAGGCCGGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTAAGGTGGGCGGATCACAAGGTCAGGAGTTTTGAGACCAGCCTGGCCAAC ATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCA CTTGAACCTGGGAGGTGGAGGTTGCAGTGAGTTGAGATCACGCCACTGCACTCCAGCCCGGGCGACAGTTCAAGACTCCATCTCAAAAAAAAAAAGAAAA GGCACACAAGAGTCCCTCACACATCTCTCTTGGAGTCTGGGATTCCATCTGTTGTATTTTCTCCTTTTTTCTCCTCTGTCTGATGCCAGAAGATACTTGT TTTCTTCTTTTCAAGAAAAGTATCTCCCCACATAGGCGGTGGACCCAAAAAGTGTAGGCATGAGACGGTCAGAGCTCTTTGGGGTCCTGCTCAGAGTCCC CCAGGCAGGGCAGAGTCTGTATCCTGCTGCCATCTTGCAAGGGAAAACCGCCTCTCCTTCCAAGTATTGGGTCTTGGAAAGGTGTGTGTTTGGTGAAAGC CACTTAATGGTGGTGGGGTGCAGCTTTTCTCTAAGTGCAGTTACTCACTCAGGACAAAGGAGGAAAAGGAAGGCAGAGGTCAGCCAGGGTAGAGGGTGAT GTCTGTTTTCCTTGGGAAACATCTGCTGATGAACTGGGTCCAGGGCCGTGCTAGGTCTGGGAACAATCCTCTCCAGGTCTTCACACAGAGTATCACCAAT CCACAAACAGACCCGAAGTGAACTAGTTTACTCTGCCTACCTGTCCTTTCAATAGAGCAGTCTTTCCCGCTCTTCTGTTCTGAGAATGCACCCGGAATGG GGGAAACCCAGCAAGCAGCAGAGAGAAAGGCTCTTCCCGGGAGACCTGCCGCCTCTAGGGTGGTCAGAGAATAGCAGCTGGGATTTTGGAGAGGGAGAGG ATAGGTAAAGCAGCGTATTGAAGCATTTGCGGAGGGGTGTATTAGTCCTCCCACCCTGAGCACACCAGGACGGGGATGCATCCTTGCCTTGTGTGCTTGT AAAGGCTTCTTTCCCTTGGTATAGCAACTTCAACTGCACCTGAACCTCCAACCTCTGCCCAGCCTCTGGTGCAGGGTGGATAGAGGTCTAGCCAGCCCTT ACTTCCTGAAGAGAGCTCTGTGGGAAACTCGAGGCTACAGTAGCTTCCCGGCTCCCAGCTCCTACCCTACCCCCACCAAAGCAGAAACGGGAGACGGCAA CGTTCTGGCTGCCATTAGACTTACGTCTCCCTCCCCTACGTCCCCTAGCTTCCCAAGACAGGAAGAAATGTGCAAAAGGCCCCTCCGGAGAAAACTATTT TGCCGTTCAGCTGTTCTTTACAGAGGATGTTATTTTAGTGAGACCCAGGTCCTAGACCTTCTGATTCCTATTTATTTTTTTAACAGACTAGTCTCAAAGT ACAGCACAAAATCTCTTCTCTGCCTTCTCTTGTGATGTTCCAGAGAGCATCTGTGGTTGTGATTTGGAATAAGTCATATTTATTTGGTTTACTGTGCCTA TTCAGATCTCTGTATGTTGTGTGTGTTTCTGTGTCCTGGAATTGGATGCGTGGGACTCGTTCTGTCCGCGGAGTGCACTCTTTTTTTCAGTGTGGCCCAC ATATCTTGTAAATGTTTGCTGAAGAGTTGTGTCTATATATAGAGAAAATATATATAAACAGAGAAATATGTGAA

refseq_RUTBC2.F2 (forward primer)
refseq_RUTBC2.R2 (reverse primer)
Single exon skipping

Frame 0

HRLLGLGTQRSEPWPRPPRRRRPDRGCYAPSRR R*SRSWRRL*HASLSTKTAATSSPSVRLWRPAFC TGFGGGRLASYAAIRLQPSL*KWARTSRRLRI* AARCKTWSS*SRARETRFKASRRMCGSCRSCPT CPHLPSSICGFAQPCLRRSWTKLCITLWKTAVNT MRRKLS*WTLWTAPSLHLCWWGPVP*STPR*RL QITSGPIPRLTNLSRGTASTAPTCGRTRPPSVL PSVSRRGIPVAAWMTGHPSLPATTWSPCIRTPVP PFSMAKTTFLFSRGTTWRLCQGTCPCTRRLTS* P*SGHPTS**TGLWGTWTMRRASTGTMP*PSAW RRLSTCTATSKLTAAGQWYWSARTGSRGRPSASP RAGTSCSSSRAWRMGCSHMGSWTRHCGPRGVRA KCFLNCASEALRVLPSPHLQTKMMMRPRIMCSG SSTLACSRNSLPPTSWAALPPSLWALPG*WFLQA GPCWWWPEGVSGSQPDGTLLSPRQARRSSPPCP RI*WTSL*ATSHPCGSPVPGSPPVHPVHRVARL MVARPMAATMRGLP*NFSVTI*STRSSPEPSMDG WPTADTCPP*EPTYQPWSIT*SCLQTCPAMLDR D*QPGSGSSTFTTAQVTRSRSCCASSTTGASSL RSARPCGPSSWATTSSG*RKQKGKSPPRAAVRAA RTSACTATPAAAHRCLSLWMRWSRWRLKADWRR NSPRSPMGT**TALVPQTRVILPPITSPRASQS TQSPV*AQKTVSWTPSGTPPRCCDLGMAAWMTGR AARPPHLRMRLPGRSWPCRTAWRVTSWPTRAWT SSCPSRAAWTWPCLKRTML*WRAGGAARQRNMA RRTVRTTSRRSLRWKVSSLPWLLWL*LLLPTRCP LCLPAASPTLQSCWICTR*TCTASRRMCRGATA TTGTSRPPTWRSCVTSCAATSGSTLRSAMSRAC VIFWLHCWSFWMMRPLPSAASRSS*RG*TRTSPT EAPWTRTLQT*DR*SRSWTQSCLS*CIRTGTIL TSTSATAGSCWISSENSSMMTSSWSGRPSGQPN TSPLRTTSCSLRWLWWKSTVTSFWRTTWISQTSS NSLMKWLSDTTPSKS*SWRGTSCTRCRL*LRTS EGHLTPAASAKLPLPRSSAYFSSWLDGHPGSGV LVSVHKRGVQCAKKLP*LLLLGRWGGGSTPSIQP YIFLFDQRLPKSGVPPLQEVEVVGGGGAIFVCW CPEWSPLLLSLSLQTVL*DETWGGNFFLEIGVE EVCGATSMLLCKGPLAMFWTWLKIDLEIDPPPRH Y*HLGPGDSF*GDCPLHCRMLSSIPGLTRCQ*C HPPTIPLVVTAPKNVSRHCEMFPAGQNCPHLRT TGLEKGLQMYFLPHSFDAKPPWS*RLPSLRKGIQ EAGHGGSHL*SQHFGRLRWADHKVRSFETSLAN MVKPHLY*KYKN*LGVVAGACNPSYLGG*GRRI T*TWEVEVAVS*DHATALQPGRQFKTPSQKKKEK AHKSPSHISLGVWDSICCIFSFFLLCLMPEDTC FLLFKKSISPHRRWTQKV*A*DGQSSLGSCSES PRQGRVCILLPSCKGKPPLLPSIGSWKGVCLVKA T*WWWGAAFL*VQLLTQDKGGKGRQRSARVEGD VCFPWETSADELGPGPC*VWEQSSPGLHTEYHQ STNRPEVN*FTLPTCPFNRAVFPALLF*ECTRNG GNPASSREKGSSRETCRL*GGQRIAAGILERER IGKAAY*SICGGVY*SSHPEHTRTGMHPCLVCL *RLLSLGIATSTAPEPPTSAQPLVQGG*RSSQPL LPEESSVGNSRLQ*LPGSQLLPYPHQSRNGRRQ RSGCH*TYVSLPYVP*LPKTGRNVQKAPPEKTI LPFSCSLQRMLF**DPGPRPSDSYLFF*QTSLKV QHKISSLPSLVMFQRASVVVIWNKSYLFGLLCL FRSLYVVCVSVSWNWMRGTRSVRGVHSFFQCGP HIL*MFAEELCLYIEKIYINREICE

Frame 1

TASWDSERSARSHGLGPRGGGDPTEAATHRQEG GEADHGGGCDTQVCPRRQQPHHLLLCGCGGLRS ARASAAGGWLPTQQ*DCSPLYESGQELPAG*GSE PQGARPGAADREREKPDSRPPGECAEAAEAAQL VPTCHQASVDSHSLV*EGPGQNCALPCGKQQ*I L*EGSSPDGPCGRPHPCIFVGGALCPRVHQDEDC RSLLDRSLG*RTCPEAPHPQLPRAAGLAHQASC PLYPEEAFQWQHG*PAIPLCPRLRGVPASELPC HPSLWQKQRSCSAEGRHGGCARVPVPAPDG*RHD LEVDTQPADERVCGGPGL*EERLLGLCHDHPLG GDCLPALPPAS*QRRDSGIGQPGRDPEAALPLP QGRAPPAVPLVPGEWAAPTWAVGPATVVPEG*GQ SVS*TAQAKPSGFCRVHIFRQR***GHGLCVQD HLPWHAVGIRCPRLLGQHFLRLCGPCLDDGSCR PVHAGGGQRESVGASQMGHYSPHAKPEGAAPHAP GSDGRLCKQPPIPVAAQSPEVLLFILFTEWLG* W*LDQWLQP*EGSPETSL*QYEVPDPLQSLLWM AGLLQTPVHRENPPISPGQSHDRVSRLALRCWTG TDSQDLGAVPSRQHKLRGAGAAAPHLLRGHPA* DPQGRVALPPGPLPVRDDGNRKERVLPELQFGP PEHPPAQRLQQQHTGV*VCG*GGAGGG*RQIGGE TAQDPQWEPSERHLFPRLGSSFLP*LLLGPLRA LRAQSEHRRQCLGRPAEHPHGAAT*GWQRG*QA EQRGHHISG*GSPGGAGRAGQPGE*PPGQREHGR VHVHHGQPGHGPA*KGRCCDGGLEEQRDRETWP GGQ*GQPLGGA*DGKSLPCPGFSGCDYFCQRGV PCVFQRRHLLSRAAGSVHGEPAPHREGCAEVRPQ LLVLHARQLGEAA*HHVQLHLAAH*DRLCPGHV *SSGSTAGHSG**GPCLQLLHGAHEEDEPELPP RRRHGHALCKHEIVDPDPGLRAV*ADASERGLYS LLLLLPLVPAGFQARTRL**RLLGLGDHLGSQT RLLCALRPVHCAGSGGSLP*HHFGEQHGFHRHH QIL**NG*ATQHQASPEAGAGPRVQGADSD*EQV RGTSPRQPQPSCPCPAPLLTFPPGWMGTPGAGS WCLFTSVEFSAQRNYPDFYFWADGVEGVPLQFS LTFSCLTKDCPSLAFLPCRRWRLLVEEEPSLFAG ARNGLLFFFPYPSKLSCKMRPGEETSFWKLV*K RCVGLPLCSSARGLWRCSGHG*RLT*RLTLHLD ITDIWGQVILFEGTVPCIVGC*AASRASPDASSA IPQPYPWL*QPPKMSLDIAKCSLQGKIAPI*EP LAWRRDYKCTSSPILLTLSHPGPDASPHLEKAY RRPGMVAHTCNPSTLGG*GGRITRSGVLRPAWPT W*NPISTKNTKISWVWWRVPVIPATWEAEAGES LEPGRWRLQ*VEITPLHSSPGDSSRLHLKKKKK RHTRVPHTSLLESGIPSVVFSPFFSSV*CQKILV FFFSRKVSPHIGGGPKKCRHETVRALWGPAQSP PGRAESVSCCHLARENRLSFQVLGLGKVCVW*K PLNGGGVQLFSKCSYSLRTKEEKEGRGQPG*RVM SVFLGKHLLMNWVQGRARSGNNPLQVFTQSITN PQTDPK*TSLLCLPVLSIEQSFPLFCSENAPGM GETQQAAERKALPGRPAASRVVRE*QLGFWRGRG *VKQRIEAFAEGCISPPTLSTPGRGCILALCAC KGFFPLV*QLQLHLNLQPLPSLWCRVDRGLASP YFLKRALWETRGYSSFPAPSSYPTPTKAETGDGN VLAAIRLTSPSPTSPSFPRQEEMCKRPLRRKLF CRSAVLYRGCYFSETQVLDLLIPIYFFNRLVSK YSTKSLLCLLL*CSREHLWL*FGISHIYLVYCAY SDLCMLCVFLCPGIGCVGLVLSAECTLFFSVAH ISCKCLLKSCVYI*RKYI*TEKYV

Frame 2

PPPGTRNAALGAMASAPAEAETRQRLLRTVKKE VKQIMEEAVTRKFVHEDSSHIISFCAAVEACVL HGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDL SRKVQDLEQLIESARNQIQGLQENVRKLPKLPNL SPLAIKHLWIRTALFEKVLDKIVHYLVENSSKY YEKEALLMDPVDGPILASLLVGPCALEYTKMKT ADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPA LCIQKRHSSGSMDDRPSLSARDYVESLHQNSRA TLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVM TLKWTPNQLMNGSVGDLDYEKSVYWDYAMTIRLE EIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFP KGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKG KVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI IYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAG RSMLVVARGSQWEPARWDTTLPTPSPKEQPPMP QDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSAD GSSTNGCNHERAPLKLLCDNMKYQILSRAFYGW LAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQ GLTARIWEQYLHDSTSYEEQELLRLIYYGGIQPE IRKAVWPFLLGHYQFGMTETERKESSQSCSSGR QNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEE KQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEH SEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQ SSEATTSQDEAPREELAVQDSLESDLLANESMD EFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQ ADSEDNLSEEPEMESLFPALASLAVTTSANEVS PVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDR NYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMC DLLAPLLVILDDEALAFSCFTELMKRMNQNFPH GGAMDTHFANMRSLIQILDSELFELMHQNGDYT HFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKH VSSAHYVLFIALALVEVYRDIILENNMDFTDII KFFNEMAERHNTKQVLKLARDLVYKVQTLIENK *GAPHPGSLSQAAPAPLLCLLFLLAGWAPRERGP GVCSQAWSSVRKETTLTFTSGQMGWREYPFNSA LHFPV*PKIAQVWRSSLAGGGGCWWRRSHLCLL VPGMVSSSSFPIPPNCLVR*DLGRKLLFGNWCRR GVWGYLYAPLQGAFGDVLDMAED*LRD*PSTST LLTFGAR*FFLRGLSPAL*DAEQHPGPHQMPVV PSPNHTPGCDSPQKCL*TLRNVPCRAKLPPFENH WLGEGTTNVLPPPFF*R*ATLVLTPPLT*KRHT GGRAWWLTPVIPALWEAKVGGSQGQEF*DQPGQ HGETPSLLKIQKLAGCGGGCL*SQLLGRLRQENH LNLGGGGCSELRSRHCTPARATVQDSISKKKRK GTQESLTHLSWSLGFHLLYFLLFSPLSDARRYL FSSFQEKYLPT*AVDPKSVGMRRSELFGVLLRVP QAGQSLYPAAILQGKTASPSKYWVLERCVFGES HLMVVGCSFSLSAVTHSGQRRKRKAEVSQGRG* CLFSLGNIC**TGSRAVLGLGTILSRSSHRVSPI HKQTRSELVYSAYLSFQ*SSLSRSSVLRMHPEW GKPSKQQRERLFPGDLPPLGWSENSSWDFGEGE DR*SSVLKHLRRGVLVLPP*AHQDGDASLPCVLV KASFPWYSNFNCT*TSNLCPASGAGWIEV*PAL TS*RELCGKLEATVASRLPAPTLPPPKQKRETA TFWLPLDLRLPPLRPLASQDRKKCAKGPSGENYF AVQLFFTEDVILVRPRS*TF*FLFIFLTD*SQS TAQNLFSAFSCDVPESICGCDLE*VIFIWFTVP IQISVCCVCFCVLELDAWDSFCPRSALFFSVWPT YLVNVC*RVVSIYRENIYKQRNM*

Sequence NM_001039948

CACCGCCTCCTGGGACTCGGAACGCAGCGCTCGGAGCCATGGCCTCGGCCCCCGCGGAGGCGGAGACCCGACAGAGGCTGCTACGCACCGTCAAGAAGGA GGTGAAGCAGATCATGGAGGAGGCTGTGACACGCAAGTTTGTCCACGAAGACAGCAGCCACATCATCTCCTTCTGTGCGGCTGTGGAGGCCTGCGTTCTG CACGGGCTTCGGCGGCGGGCGGCTGGCTTCCTACGCAGCAATAAGATTGCAGCCCTCTTTATGAAAGTGGGCAAGAACTTCCCGCCGGCTGAGGATCTGA GCCGCAAGGTGCAAGACCTGGAGCAGCTGATCGAGAGCGCGAGAAACCAGATTCAAGGCCTCCAGGAGAATGTGCGGAAGCTGCCGAAGCTGCCCAACTT GTCCCCACTTGCCATCAAGCATCTGTGGATTCGCACAGCCTTGTTTGAGAAGGTCCTGGACAAAATTGTGCATTACCTTGTGGAAAACAGCAGTAAATAC TATGAGAAGGAAGCTCTCCTGATGGACCCTGTGGACGGCCCCATCCTTGCATCTTTGTTGGTGGGGCCCTGTGCCCTAGAGTACACCAAGATGAAGACTG CAGATCACTTCTGGACCGATCCCTCGGCTGACGAACTTGTCCAGAGGCACCGCATCCACAGCTCCCACGTGCGGCAGGACTCGCCCACCAAGCGTCCTGC CCTCTGTATCCAGAAGAGGCATTCCAGTGGCAGCATGGATGACCGGCCATCCCTCTCTGCCCGCGACTACGTGGAGTCCCTGCATCAGAACTCCCGTGCC ACCCTTCTCTATGGCAAAAACAACGTTCTTGTTCAGCCGAGGGACGACATGGAGGCTGTGCCAGGGTACCTGTCCCTGCACCAGACGGCTGACGTCATGA CCTTGAAGTGGACACCCAACCAGCTGATGAACGGGTCTGTGGGGGACCTGGACTATGAGAAGAGCGTCTACTGGGACTATGCCATGACCATCCGCTTGGA GGAGATTGTCTACCTGCACTGCCACCAGCAAGTTGACAGCGGCGGGACAGTGGTATTGGTCAGCCAGGACGGGATCCAGAGGCCGCCCTTCCGCTTCCCC AAGGGCGGGCACCTCCTGCAGTTCCTCTCGTGCCTGGAGAATGGGCTGCTCCCACATGGGCAGTTGGACCCGCCACTGTGGTCCCAGAGGGGTAAGGGCA AAGTGTTTCCTAAACTGCGCAAGCGAAGCCCTCAGGGTTCTGCCGAGTCCACATCTTCAGACAAAGATGATGATGAGGCCACGGATTATGTGTTCAGGAT CATCTACCCTGGCATGCAGTCGGAATTCGTTGCCCCCGACTTCTTGGGCAGCACTTCCTCCGTCTCTGTGGGCCCTGCCTGGATGATGGTTCCTGCAGGC CGGTCCATGCTGGTGGTGGCCAGAGGGAGTCAGTGGGAGCCAGCCAGATGGGACACTACTCTCCCCACGCCAAGCCCGAAGGAGCAGCCCCCCATGCCCC AGGATCTGATGGACGTCTCTGTAAGCAACCTCCCATCCCTGTGGCAGCCCAGTCCCCGGAAGTCCTCCTGTTCATCCTGTTCACAGAGTGGCTCGGCTGA TGGTAGCTCGACCAATGGCTGCAACCATGAGAGGGCTCCCCTGAAACTTCTCTGTGACAATATGAAGTACCAGATCCTCTCCAGAGCCTTCTATGGATGG CTGGCCTACTGCAGACACCTGTCCACCGTGAGAACCCACCTATCAGCCCTGGTCAATCACATGATCGTGTCTCCAGACTTGCCCTGCGATGCTGGACAGG GACTGACAGCCAGGATCTGGGAGCAGTACCTTCACGACAGCACAAGTTACGAGGAGCAGGAGCTGCTGCGCCTCATCTACTACGGGGGCATCCAGCCTGA GATCCGCAAGGCCGTGTGGCCCTTCCTCCTGGGCCACTACCAGTTCGGGATGACGGAAACAGAAAGGAAAGAGGTGGACGAGCAGATTCATGCCTGCTAT GCACAGACCATGGCTGAGTGGCTGGGCTGCGAGGCGATCGTGCGGCAGAGGGAGCGGGAGTCCCATGCGGCCGCCCTGGCCAAATGCTCATCCGGGGCCA GCTTGGACAGCCACCTGCACCGGATGTTGCACAGGGACTCAACCATCAGCAATGAGTCCTCCCAGAGCTGCAGTTCGGGCCGCCAGAACATCCGCCTGCA CAGCGACTCCAGCAGCAGCACACAGGTGTTTGAGTCTGTGGATGAGGTGGAGCAGGTGGAGGCTGAAGGCAGATTGGAGGAGAAACAGCCCAAGATCCCC AATGGGAACCTAGTGAACGGCACTTGTTCCCCAGACTCGGGTCATCCTTCCTCCCATAACTTCTCCTCGGGCCTCTCAGAGCACTCAGAGCCCAGTCTGA GCACAGAAGACAGTGTCTTGGACGCCCAGCGGAACACCCCCACGGTGCTGCGACCTAGGGATGGCAGCGTGGATGACAGGCAGAGCAGCGAGGCCACCAC ATCTCAGGATGAGGCTCCCCGGGAGGAGCTGGCCGTGCAGGACAGCCTGGAGAGTGACCTCCTGGCCAACGAGAGCATGGACGAGTTCATGTCCATCACG GGCAGCCTGGACATGGCCCTGCCTGAAAAGGACGATGTTGTGATGGAGGGCTGGAGGAGCAGCGAGACAGAGAAACATGGCCAGGCGGACAGTGAGGACA ACCTCTCGGAGGAGCCTGAGATGGAAAGTCTCTTCCCTGCCCTGGCTTCTCTGGCTGTGACTACTTCTGCCAACGAGGTGTCCCCTGTGTCTTCCAGCGG CGTCACCTACTCTCCAGAGCTGCTGGATCTGTACACGGTGAACCTGCACCGCATCGAGAAGGATGTGCAGAGGTGCGACCGCAACTACTGGTACTTCACG CCCGCCAACTTGGAGAAGCTGCGTAACATCATGTGCAGCTACATCTGGCAGCACATTGAGATCGGCTATGTCCAGGGCATGTGTGATCTTCTGGCTCCAC TGCTGGTCATTCTGGATGATGAGGCCCTTGCCTTCAGCTGCTTCACGGAGCTCATGAAGAGGATGAACCAGAACTTCCCCCACGGAGGCGCCATGGACAC GCACTTTGCAAACATGAGATCGTTGATCCAGATCCTGGACTCAGAGCTGTTTGAGCTGATGCATCAGAACGGGGACTATACTCACTTCTACTTCTGCTAC CGCTGGTTCCTGCTGGATTTCAAGCGAGAACTCGTCTATGATGACGTCTTCTTGGTCTGGGAGACCATCTGGGCAGCCAAACACGTCTCCTCTGCGCACT ACGTCCTGTTCATTGCGCTGGCTCTGGTGGAAGTCTACCGTGACATCATTTTGGAGAACAACATGGATTTCACAGACATCATCAAATTCTTTAATGAAAT GGCTGAGCGACACAACACCAAGCAAGTCCTGAAGCTGGCGCGGGACCTCGTGTACAAGGTGCAGACTCTGATTGAGAACAAGTGAGGGGCACCTCACCCC GGCAGCCTCAGCCAAGCTGCCCCTGCCCCGCTCCTCTGCTTACTTTTCCTCCTGGCTGGATGGGCACCCCGGGAGCGGGGTCCTGGTGTCTGTTCACAAG CGTGGAGTTCAGTGCGCAAAGAAACTACCCTGACTTTTACTTCTGGGCAGATGGGGTGGAGGGAGTACCCCTTCAATTCAGCCTTACATTTTCCTGTTTG ACCAAAGATTGCCCAAGTCTGGCGTTCCTCCCTTGCAGGAGGTGGAGGTTGTTGGTGGAGGAGGAGCCATCTTTGTTTGCTGGTGCCCGGAATGGTCTCC TCTTCTTCTTTCCCTATCCCTCCAAACTGTCTTGTAAGATGAGACCTGGGGAGGAAACTTCTTTTTGGAAATTGGTGTAGAAGAGGTGTGTGGGGCTACC TCTATGCTCCTCTGCAAGGGGCCTTTGGCGATGTTCTGGACATGGCTGAAGATTGACTTAGAGATTGACCCTCCACCTCGACATTACTGACATTTGGGGC CAGGTGATTCTTTTTGAGGGGACTGTCCCCTGCATTGTAGGATGCTGAGCAGCATCCCGGGCCTCACCAGATGCCAGTAGTGCCATCCCCCAACCATACC CCTGGTTGTGACAGCCCCCAAAAATGTCTCTAGACATTGCGAAATGTTCCCTGCAGGGCAAAATTGCCCCCATTTGAGAACCACTGGCTTGGAGAAGGGA CTACAAATGTACTTCCTCCCCCATTCTTTTGACGCTAAGCCACCCTGGTCCTGACGCCTCCCCTCACTTAGAAAAGGCATACAGGAGGCCGGGCATGGTG GCTCACACCTGTAATCCCAGCACTTTGGGAGGCTAAGGTGGGCGGATCACAAGGTCAGGAGTTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCT CTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTG GAGGTTGCAGTGAGTTGAGATCACGCCACTGCACTCCAGCCCGGGCGACAGTTCAAGACTCCATCTCAAAAAAAAAAAGAAAAGGCACACAAGAGTCCCT CACACATCTCTCTTGGAGTCTGGGATTCCATCTGTTGTATTTTCTCCTTTTTTCTCCTCTGTCTGATGCCAGAAGATACTTGTTTTCTTCTTTTCAAGAA AAGTATCTCCCCACATAGGCGGTGGACCCAAAAAGTGTAGGCATGAGACGGTCAGAGCTCTTTGGGGTCCTGCTCAGAGTCCCCCAGGCAGGGCAGAGTC TGTATCCTGCTGCCATCTTGCAAGGGAAAACCGCCTCTCCTTCCAAGTATTGGGTCTTGGAAAGGTGTGTGTTTGGTGAAAGCCACTTAATGGTGGTGGG GTGCAGCTTTTCTCTAAGTGCAGTTACTCACTCAGGACAAAGGAGGAAAAGGAAGGCAGAGGTCAGCCAGGGTAGAGGGTGATGTCTGTTTTCCTTGGGA AACATCTGCTGATGAACTGGGTCCAGGGCCGTGCTAGGTCTGGGAACAATCCTCTCCAGGTCTTCACACAGAGTATCACCAATCCACAAACAGACCCGAA GTGAACTAGTTTACTCTGCCTACCTGTCCTTTCAATAGAGCAGTCTTTCCCGCTCTTCTGTTCTGAGAATGCACCCGGAATGGGGGAAACCCAGCAAGCA GCAGAGAGAAAGGCTCTTCCCGGGAGACCTGCCGCCTCTAGGGTGGTCAGAGAATAGCAGCTGGGATTTTGGAGAGGGAGAGGATAGGTAAAGCAGCGTA TTGAAGCATTTGCGGAGGGGTGTATTAGTCCTCCCACCCTGAGCACACCAGGACGGGGATGCATCCTTGCCTTGTGTGCTTGTAAAGGCTTCTTTCCCTT GGTATAGCAACTTCAACTGCACCTGAACCTCCAACCTCTGCCCAGCCTCTGGTGCAGGGTGGATAGAGGTCTAGCCAGCCCTTACTTCCTGAAGAGAGCT CTGTGGGAAACTCGAGGCTACAGTAGCTTCCCGGCTCCCAGCTCCTACCCTACCCCCACCAAAGCAGAAACGGGAGACGGCAACGTTCTGGCTGCCATTA GACTTACGTCTCCCTCCCCTACGTCCCCTAGCTTCCCAAGACAGGAAGAAATGTGCAAAAGGCCCCTCCGGAGAAAACTATTTTGCCGTTCAGCTGTTCT TTACAGAGGATGTTATTTTAGTGAGACCCAGGTCCTAGACCTTCTGATTCCTATTTATTTTTTTAACAGACTAGTCTCAAAGTACAGCACAAAATCTCTT CTCTGCCTTCTCTTGTGATGTTCCAGAGAGCATCTGTGGTTGTGATTTGGAATAAGTCATATTTATTTGGTTTACTGTGCCTATTCAGATCTCTGTATGT TGTGTGTGTTTCTGTGTCCTGGAATTGGATGCGTGGGACTCGTTCTGTCCGCGGAGTGCACTCTTTTTTTCAGTGTGGCCCACATATCTTGTAAATGTTT GCTGAAGAGTTGTGTCTATATATAGAGAAAATATATATAAACAGAGAAATATGTGAA

refseq_RUTBC2.F2 (forward primer)
refseq_RUTBC2.R2 (reverse primer)
Single exon skipping

Frame 0

HRLLGLGTQRSEPWPRPPRRRRPDRGCYAPSRR R*SRSWRRL*HASLSTKTAATSSPSVRLWRPAFC TGFGGGRLASYAAIRLQPSL*KWARTSRRLRI* AARCKTWSS*SRARETRFKASRRMCGSCRSCPT CPHLPSSICGFAQPCLRRSWTKLCITLWKTAVNT MRRKLS*WTLWTAPSLHLCWWGPVP*STPR*RL QITSGPIPRLTNLSRGTASTAPTCGRTRPPSVL PSVSRRGIPVAAWMTGHPSLPATTWSPCIRTPVP PFSMAKTTFLFSRGTTWRLCQGTCPCTRRLTS* P*SGHPTS**TGLWGTWTMRRASTGTMP*PSAW RRLSTCTATSKLTAAGQWYWSARTGSRGRPSASP RAGTSCSSSRAWRMGCSHMGSWTRHCGPRGVRA KCFLNCASEALRVLPSPHLQTKMMMRPRIMCSG SSTLACSRNSLPPTSWAALPPSLWALPG*WFLQA GPCWWWPEGVSGSQPDGTLLSPRQARRSSPPCP RI*WTSL*ATSHPCGSPVPGSPPVHPVHRVARL MVARPMAATMRGLP*NFSVTI*STRSSPEPSMDG WPTADTCPP*EPTYQPWSIT*SCLQTCPAMLDR D*QPGSGSSTFTTAQVTRSRSCCASSTTGASSL RSARPCGPSSWATTSSG*RKQKGKRWTSRFMPAM HRPWLSGWAARRSCGRGSGSPMRPPWPNAHPGP AWTATCTGCCTGTQPSAMSPPRAAVRAARTSAC TATPAAAHRCLSLWMRWSRWRLKADWRRNSPRSP MGT**TALVPQTRVILPPITSPRASQSTQSPV* AQKTVSWTPSGTPPRCCDLGMAAWMTGRAARPP HLRMRLPGRSWPCRTAWRVTSWPTRAWTSSCPSR AAWTWPCLKRTML*WRAGGAARQRNMARRTVRT TSRRSLRWKVSSLPWLLWL*LLLPTRCPLCLPA ASPTLQSCWICTR*TCTASRRMCRGATATTGTSR PPTWRSCVTSCAATSGSTLRSAMSRACVIFWLH CWSFWMMRPLPSAASRSS*RG*TRTSPTEAPWT RTLQT*DR*SRSWTQSCLS*CIRTGTILTSTSAT AGSCWISSENSSMMTSSWSGRPSGQPNTSPLRT TSCSLRWLWWKSTVTSFWRTTWISQTSSNSLMK WLSDTTPSKS*SWRGTSCTRCRL*LRTSEGHLTP AASAKLPLPRSSAYFSSWLDGHPGSGVLVSVHK RGVQCAKKLP*LLLLGRWGGGSTPSIQPYIFLF DQRLPKSGVPPLQEVEVVGGGGAIFVCWCPEWSP LLLSLSLQTVL*DETWGGNFFLEIGVEEVCGAT SMLLCKGPLAMFWTWLKIDLEIDPPPRHY*HLG PGDSF*GDCPLHCRMLSSIPGLTRCQ*CHPPTIP LVVTAPKNVSRHCEMFPAGQNCPHLRTTGLEKG LQMYFLPHSFDAKPPWS*RLPSLRKGIQEAGHG GSHL*SQHFGRLRWADHKVRSFETSLANMVKPHL Y*KYKN*LGVVAGACNPSYLGG*GRRIT*TWEV EVAVS*DHATALQPGRQFKTPSQKKKEKAHKSP SHISLGVWDSICCIFSFFLLCLMPEDTCFLLFKK SISPHRRWTQKV*A*DGQSSLGSCSESPRQGRV CILLPSCKGKPPLLPSIGSWKGVCLVKAT*WWW GAAFL*VQLLTQDKGGKGRQRSARVEGDVCFPWE TSADELGPGPC*VWEQSSPGLHTEYHQSTNRPE VN*FTLPTCPFNRAVFPALLF*ECTRNGGNPAS SREKGSSRETCRL*GGQRIAAGILERERIGKAAY *SICGGVY*SSHPEHTRTGMHPCLVCL*RLLSL GIATSTAPEPPTSAQPLVQGG*RSSQPLLPEES SVGNSRLQ*LPGSQLLPYPHQSRNGRRQRSGCH* TYVSLPYVP*LPKTGRNVQKAPPEKTILPFSCS LQRMLF**DPGPRPSDSYLFF*QTSLKVQHKIS SLPSLVMFQRASVVVIWNKSYLFGLLCLFRSLYV VCVSVSWNWMRGTRSVRGVHSFFQCGPHIL*MF AEELCLYIEKIYINREICE

Frame 1

TASWDSERSARSHGLGPRGGGDPTEAATHRQEG GEADHGGGCDTQVCPRRQQPHHLLLCGCGGLRS ARASAAGGWLPTQQ*DCSPLYESGQELPAG*GSE PQGARPGAADREREKPDSRPPGECAEAAEAAQL VPTCHQASVDSHSLV*EGPGQNCALPCGKQQ*I L*EGSSPDGPCGRPHPCIFVGGALCPRVHQDEDC RSLLDRSLG*RTCPEAPHPQLPRAAGLAHQASC PLYPEEAFQWQHG*PAIPLCPRLRGVPASELPC HPSLWQKQRSCSAEGRHGGCARVPVPAPDG*RHD LEVDTQPADERVCGGPGL*EERLLGLCHDHPLG GDCLPALPPAS*QRRDSGIGQPGRDPEAALPLP QGRAPPAVPLVPGEWAAPTWAVGPATVVPEG*GQ SVS*TAQAKPSGFCRVHIFRQR***GHGLCVQD HLPWHAVGIRCPRLLGQHFLRLCGPCLDDGSCR PVHAGGGQRESVGASQMGHYSPHAKPEGAAPHAP GSDGRLCKQPPIPVAAQSPEVLLFILFTEWLG* W*LDQWLQP*EGSPETSL*QYEVPDPLQSLLWM AGLLQTPVHRENPPISPGQSHDRVSRLALRCWTG TDSQDLGAVPSRQHKLRGAGAAAPHLLRGHPA* DPQGRVALPPGPLPVRDDGNRKERGGRADSCLL CTDHG*VAGLRGDRAAEGAGVPCGRPGQMLIRGQ LGQPPAPDVAQGLNHQQ*VLPELQFGPPEHPPA QRLQQQHTGV*VCG*GGAGGG*RQIGGETAQDP QWEPSERHLFPRLGSSFLP*LLLGPLRALRAQSE HRRQCLGRPAEHPHGAAT*GWQRG*QAEQRGHH ISG*GSPGGAGRAGQPGE*PPGQREHGRVHVHH GQPGHGPA*KGRCCDGGLEEQRDRETWPGGQ*GQ PLGGA*DGKSLPCPGFSGCDYFCQRGVPCVFQR RHLLSRAAGSVHGEPAPHREGCAEVRPQLLVLH ARQLGEAA*HHVQLHLAAH*DRLCPGHV*SSGST AGHSG**GPCLQLLHGAHEEDEPELPPRRRHGH ALCKHEIVDPDPGLRAV*ADASERGLYSLLLLL PLVPAGFQARTRL**RLLGLGDHLGSQTRLLCAL RPVHCAGSGGSLP*HHFGEQHGFHRHHQIL**N G*ATQHQASPEAGAGPRVQGADSD*EQVRGTSP RQPQPSCPCPAPLLTFPPGWMGTPGAGSWCLFTS VEFSAQRNYPDFYFWADGVEGVPLQFSLTFSCL TKDCPSLAFLPCRRWRLLVEEEPSLFAGARNGL LFFFPYPSKLSCKMRPGEETSFWKLV*KRCVGLP LCSSARGLWRCSGHG*RLT*RLTLHLDITDIWG QVILFEGTVPCIVGC*AASRASPDASSAIPQPY PWL*QPPKMSLDIAKCSLQGKIAPI*EPLAWRRD YKCTSSPILLTLSHPGPDASPHLEKAYRRPGMV AHTCNPSTLGG*GGRITRSGVLRPAWPTW*NPI STKNTKISWVWWRVPVIPATWEAEAGESLEPGRW RLQ*VEITPLHSSPGDSSRLHLKKKKKRHTRVP HTSLLESGIPSVVFSPFFSSV*CQKILVFFFSR KVSPHIGGGPKKCRHETVRALWGPAQSPPGRAES VSCCHLARENRLSFQVLGLGKVCVW*KPLNGGG VQLFSKCSYSLRTKEEKEGRGQPG*RVMSVFLG KHLLMNWVQGRARSGNNPLQVFTQSITNPQTDPK *TSLLCLPVLSIEQSFPLFCSENAPGMGETQQA AERKALPGRPAASRVVRE*QLGFWRGRG*VKQR IEAFAEGCISPPTLSTPGRGCILALCACKGFFPL V*QLQLHLNLQPLPSLWCRVDRGLASPYFLKRA LWETRGYSSFPAPSSYPTPTKAETGDGNVLAAI RLTSPSPTSPSFPRQEEMCKRPLRRKLFCRSAVL YRGCYFSETQVLDLLIPIYFFNRLVSKYSTKSL LCLLL*CSREHLWL*FGISHIYLVYCAYSDLCM LCVFLCPGIGCVGLVLSAECTLFFSVAHISCKCL LKSCVYI*RKYI*TEKYV

Frame 2

PPPGTRNAALGAMASAPAEAETRQRLLRTVKKE VKQIMEEAVTRKFVHEDSSHIISFCAAVEACVL HGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDL SRKVQDLEQLIESARNQIQGLQENVRKLPKLPNL SPLAIKHLWIRTALFEKVLDKIVHYLVENSSKY YEKEALLMDPVDGPILASLLVGPCALEYTKMKT ADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPA LCIQKRHSSGSMDDRPSLSARDYVESLHQNSRA TLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVM TLKWTPNQLMNGSVGDLDYEKSVYWDYAMTIRLE EIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFP KGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKG KVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI IYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAG RSMLVVARGSQWEPARWDTTLPTPSPKEQPPMP QDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSAD GSSTNGCNHERAPLKLLCDNMKYQILSRAFYGW LAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQ GLTARIWEQYLHDSTSYEEQELLRLIYYGGIQPE IRKAVWPFLLGHYQFGMTETERKEVDEQIHACY AQTMAEWLGCEAIVRQRERESHAAALAKCSSGA SLDSHLHRMLHRDSTISNESSQSCSSGRQNIRLH SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIP NGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSL STEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATT SQDEAPREELAVQDSLESDLLANESMDEFMSIT GSLDMALPEKDDVVMEGWRSSETEKHGQADSED NLSEEPEMESLFPALASLAVTTSANEVSPVSSSG VTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFT PANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAP LLVILDDEALAFSCFTELMKRMNQNFPHGGAMDT HFANMRSLIQILDSELFELMHQNGDYTHFYFCY RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAH YVLFIALALVEVYRDIILENNMDFTDIIKFFNEM AERHNTKQVLKLARDLVYKVQTLIENK*GAPHP GSLSQAAPAPLLCLLFLLAGWAPRERGPGVCSQ AWSSVRKETTLTFTSGQMGWREYPFNSALHFPV* PKIAQVWRSSLAGGGGCWWRRSHLCLLVPGMVS SSSFPIPPNCLVR*DLGRKLLFGNWCRRGVWGY LYAPLQGAFGDVLDMAED*LRD*PSTSTLLTFGA R*FFLRGLSPAL*DAEQHPGPHQMPVVPSPNHT PGCDSPQKCL*TLRNVPCRAKLPPFENHWLGEG TTNVLPPPFF*R*ATLVLTPPLT*KRHTGGRAWW LTPVIPALWEAKVGGSQGQEF*DQPGQHGETPS LLKIQKLAGCGGGCL*SQLLGRLRQENHLNLGG GGCSELRSRHCTPARATVQDSISKKKRKGTQESL THLSWSLGFHLLYFLLFSPLSDARRYLFSSFQE KYLPT*AVDPKSVGMRRSELFGVLLRVPQAGQS LYPAAILQGKTASPSKYWVLERCVFGESHLMVVG CSFSLSAVTHSGQRRKRKAEVSQGRG*CLFSLG NIC**TGSRAVLGLGTILSRSSHRVSPIHKQTR SELVYSAYLSFQ*SSLSRSSVLRMHPEWGKPSKQ QRERLFPGDLPPLGWSENSSWDFGEGEDR*SSV LKHLRRGVLVLPP*AHQDGDASLPCVLVKASFP WYSNFNCT*TSNLCPASGAGWIEV*PALTS*REL CGKLEATVASRLPAPTLPPPKQKRETATFWLPL DLRLPPLRPLASQDRKKCAKGPSGENYFAVQLF FTEDVILVRPRS*TF*FLFIFLTD*SQSTAQNLF SAFSCDVPESICGCDLE*VIFIWFTVPIQISVC CVCFCVLELDAWDSFCPRSALFFSVWPTYLVNV C*RVVSIYRENIYKQRNM*