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Sequences

Sequence NM_130854

ATTCCATCCCATCACCCCATGATCCTTCCCCATTGTCCCATGACCAGCCCCCGCAGGACCCTCCCCTGCTCCATGTGACCCTCCCTCTGCCTCCTCCATG AAGGTCTCCTGGATTTCCCCACTCGCCTCTCACAGCCCTCCATTGTCTCTGCAGACGTTGCCCCATCTGACGCTCGGCTCGAGGCCTCTCTGTGAGGGAC CGGGGGGCCATCCCCCTCCAGGGCGGAGATCGGAGGTCGCTGCCAAGCATGGCGCCCACCTGGGGCCCTGGCATGGTGTCTGTGGTTGGTCCCATGGGCC TCCTTGTGGTCCTGCTCGTTGGAGGCTGTGCAGCAGAAGAGCCCCCCAGGTTTATCAAAGAACCCAAGGACCAGATCGGCGTGTCGGGGGGTGTGGCCTC TTTCGTGTGTCAGGCCACGGGTGACCCCAAGCCACGAGTGACCTGGAACAAGAAGGGCAAGAAGGTCAACTCTCAGCGCTTTGAGACGATTGAGTTTGAT GAGAGTGCAGGGGCAGTGCTGAGGATCCAGCCGCTGAGGACACCGCGGGATGAAAACGTGTACGAGTGTGTGGCCCAGAACTCGGTTGGGGAGATCACAG TCCATGCCAAGCTTACTGTCCTCCGAGAGGACCAGCTGCCCTCTGGCTTCCCCAACATCGACATGGGCCCACAGTTGAAGGTGGTGGAGCGGACACGGAC AGCCACCATGCTCTGTGCAGCCAGCGGCAACCCTGACCCTGAGATCACCTGGTTCAAGGACTTCCTGCCTGTGGATCCTAGTGCCAGCAATGGACGCATC AAACAGCTGCGATCAGGAGCCCTGCAGATTGAAAGCAGTGAGGAAACCGACCAGGGCAAATATGAGTGTGTGGCCACCAACAGCGCCGGCGTGCGCTACT CCTCACCTGCCAACCTCTACGTGCGAGTCCGCCGCGTGGCCCCGCGCTTCTCCATCCTGCCCATGAGCCACGAGATCATGCCAGGGGGCAACGTGAACAT CACCTGCGTGGCCGTGGGCTCGCCCATGCCATACGTGAAGTGGATGCAGGGGGCCGAGGACCTGACCCCCGAGGATGACATGCCCGTGGGTCGGAACGTG CTGGAACTCACAGATGTCAAGGACTCGGCCAACTACACCTGCGTGGCCATGTCCAGCCTGGGCGTCATTGAGGCGGTTGCTCAGATCACGGTGAAATCTC TCCCCAAAGCTCCCGGGACTCCCATGGTGACTGAGAACACAGCCACCAGCATCACCATCACGTGGGACTCGGGCAACCCAGATCCTGTGTCCTATTACGT CATCGAATATAAATCCAAGAGCCAAGACGGGCCGTATCAGATTAAAGAGGACATCACCACCACACGTTACAGCATCGGCGGCCTGAGCCCCAACTCGGAG TACGAGATCTGGGTGTCGGCCGTCAACTCCATCGGCCAGGGGCCCCCCAGCGAGTCCGTGGTCACCCGCACAGGCGAGCAGGCCCCGGCCAGCGCGCCGC GGAACGTGCAAGCCCGGATGCTCAGCGCGACCACCATGATTGTGCAGTGGGAGGAGCCGGTGGAGCCCAACGGCCTGATCCGCGGCTACCGCGTCTACTA CACCATGGAACCGGAGCACCCCGTGGGCAACTGGCAGAAGCACAACGTGGACGACAGCCTGCTGACCACCGTGGGCAGCCTGCTGGAGGACGAGACCTAC ACCGTGCGGGTGCTCGCCTTCACCTCCGTCGGCGACGGGCCCCTCTCGGACCCCATCCAGGTCAAGACGCAGCAGGGAGTGCCGGGCCAGCCCATGAACC TGCGGGCCGAGGCCAGGTCGGAGACCAGCATCACGCTGTCCTGGAGCCCCCCGCGGCAGGAGAGTATCATCAAGTACGAGCTCCTCTTCCGGGAAGGCGA CCATGGCCGGGAGGTGGGAAGGACCTTCGACCCGACGACTTCCTACGTGGTGGAGGACCTGAAGCCCAACACGGAGTACGCCTTCCGCCTGGCGGCCCGC TCGCCGCAGGGCCTGGGCGCCTTCACCCCCGTGGTGCGGCAGCGCACGCTGCAGTCCAAACCGTCAGCCCCCCCTCAAGACGTTAAATGTGTCAGCGTGC GCTCCACGGCCATTTTGGTAAGTTGGCGCCCGCCGCCGCCGGAAACGCACAACGGGGCCCTGGTGGGCTACAGCGTCCGCTACCGACCGCTGGGCTCAGA GGACCCGGAACCCAAGGAGGTGAACGGCATCCCCCCGACCACCACTCAGATCCTGCTGGAGGCCTTGGAGAAGTGGACCCAGTACCGCATCACGACTGTC GCTCACACAGAGGTGGGACCAGGGCCCGAGAGCTCGCCCGTGGTCGTCCGCACCGACGAGGATGTGCCCAGCGCGCCGCCGCGGAAGGTGGAGGCGGAGG CGCTCAACGCCACGGCCATCCGCGTGCTGTGGCGCTCGCCCGCGCCCGGCCGGCAGCACGGCCAGATCCGCGGCTACCAGGTCCACTACGTGCGCATGGA GGGCGCCGAGGCCCGCGGGCCGCCGCGCATCAAGGACGTCATGCTGGCCGATGCCCAGGAGATGGTCATCACAAACTTGCAGCCTGAGACCGCGTACTCC ATCACGGTAGCCGCCTACACCATGAAGGGCGATGGCGCTCGCAGCAAACCCAAGGTGGTTGTGACCAAGGGAGCAGTGCTGGGCCGCCCAACCCTGTCGG TGCAGCAGACCCCCGAGGGCAGCCTGCTGGCACGCTGGGAGCCCCCGGCTGGCACCGCGGAGGACCAGGTGCTGGGCTACCGCCTGCAGTTTGGCCGTGA GGACTCGACGCCCCTGGCCACCCTGGAGTTCCCGCCCTCCGAGGACCGCTACACGGCATCAGGCGTGCACAAGGGGGCCACGTATGTGTTCCGGCTTGCG GCCCGGAGCCGCGGCGGCCTGGGCGAGGAGGCAGCCGAGGTCCTGAGCATCCCGGAGGACACGCCCCGTGGCCACCCGCAGATTCTGGAGGCGGCCGGCA ACGCCTCGGCCGGGACCGTCCTTCTCCGCTGGCTGCCACCCGTGCCCGCCGAGCGCAACGGGGCCATCGTCAAATACACGGTGGCCGTGCGGGAGGCCGG TGCCCTGGGCCCTGCCCGAGAGACTGAGCTGCCGGCAGCGGCTGAGCCGGGCGCGGAGAACGCGCTCACGCTGCAGGGCCTGAAGCCCGACACGGCCTAT GACCTCCAAGTGCGAGCCCACACGCGCCGGGGCCCTGGCCCCTTCAGCCCCCCCGTCCGCTACCGGACGTTCCTGCGGGACCAAGTCTCGCCCAAGAACT TCAAGGTGAAAATGATCATGAAGACATCAGTTCTGCTCAGCTGGGAGTTCCCTGACAACTACAACTCACCCACACCCTACAAGATCCAGTACAATGGGCT CACACTGGATGTGGATGGCCGTACCACCAAGAAGCTCATCACGCACCTCAAGCCCCACACCTTCTACAACTTTGTGCTGACCAATCGCGGCAGCAGCCTG GGCGGCCTCCAGCAGACGGTCACCGCCTGGACTGCCTTCAACCTGCTCAACGGCAAGCCCAGCGTCGCCCCCAAGCCTGATGCTGACGGCTTCATCATGG TGTATCTTCCTGACGGCCAGAGCCCCGTGCCTGTCCAGAGCTATTTCATTGTGATGGTGCCACTGCGCAAGTCTCGTGGAGGCCAATTCCTGACCCCGCT GGGTAGCCCAGAGGACATGGATCTGGAAGAGCTCATCCAGGACATCTCACGGCTACAGAGGCGCAGCCTGCGGCACTCGCGTCAGCTGGAGGTGCCCCGG CCCTATATTGCAGCTCGCTTCTCTGTGCTGCCACCCACGTTCCATCCCGGCGACCAGAAGCAGTATGGCGGCTTCGATAACCGGGGCCTGGAGCCCGGCC ACCGCTATGTCCTCTTCGTGCTTGCCGTGCTTCAGAAGAGCGAGCCTACCTTTGCAGCCAGTCCCTTCTCAGACCCCTTCCAGCTGGATAACCCGGACCC CCAGCCCATCGTGGATGGCGAGGAGGGGCTTATCTGGGTGATCGGGCCTGTGCTGGCCGTGGTCTTCATAATCTGCATTGTCATTGCTATCCTGCTCTAC AAGAACAAACCCGACAGTAAACGCAAGGACTCAGAACCCCGCACCAAATGCCTCCTGAACAATGCCGACCTCGCCCCTCACCACCCCAAGGACCCTGTGG AAATGAGACGCATTAACTTCCAGACTCCAGGCATGCTTAGCCACCCGCCAATTCCCATCGCAGACATGGCGGAGCACACGGAGCGGCTCAAGGCCAACGA CAGCCTCAAGCTCTCCCAGGAGTATGAGTCCATCGACCCTGGACAGCAGTTCACATGGGAACATTCCAACCTGGAAGTGAACAAGCCGAAGAACCGCTAT GCCAACGTCATCGCCTATGACCACTCCCGTGTCATCCTCCAGCCCATTGAAGGCATCATGGGCAGTGATTACATCAATGCCAACTACGTGGACGGCTACC GGTGTCAGAACGCGTACATTGCCACGCAGGGGCCGCTGCCTGAGACCTTTGGGGACTTCTGGCGTATGGTGTGGGAGCAGCGGTCGGCGACCATCGTCAT GATGACGCGGCTGGAGGAGAAGTCACGGATCAAGTGTGATCAGTATTGGCCCAACAGAGGCACGGAGACCTACGGCTTCATCCAGGTCACGTTGCTAGAT ACCATCGAGCTGGCCACATTCTGCGTCAGGACATTCTCTCTGCACAAGAATGGCTCCAGTGAGAAACGCGAGGTCCGCCAGTTCCAGTTTACGGCGTGGC CGGACCATGGCGTGCCCGAATACCCAACGCCCTTCCTGGCTTTCCTGCGGAGAGTCAAGACCTGCAACCCGCCAGATGCCGGCCCCATCGTGGTTCACTG CAGTGCCGGTGTGGGCCGCACAGGCTGCTTTATCGTCATCGACGCCATGCTTGAGCGGATCAAGCCAGAGAAGACAGTCGATGTCTATGGCCACGTGACG CTCATGAGGTCCCAGCGCAACTACATGGTGCAGACGGAGGACCAGTACAGCTTCATCCACGAGGCCCTGCTGGAGGCCGTGGGCTGTGGCAACACAGAAG TGCCCGCACGCAGCCTCTATGCCTACATCCAGAAGCTGGCCCAGGTGGAGCCTGGCGAACACGTCACTGGCATGGAACTCGAGTTCAAGCGGCTGGCTAA CTCCAAGGCCCACACGTCACGCTTCATCAGTGCCAATCTGCCTTGTAACAAGTTCAAGAACCGCCTGGTGAACATCATGCCCTATGAGAGCACACGGGTC TGTCTGCAACCCATCCGGGGTGTGGAGGGCTCTGACTACATCAACGCCAGCTTCATTGATGGCTACAGGCAGCAGAAGGCCTACATCGCGACACAGGGGC CGCTGGCGGAGACCACGGAAGACTTCTGGCGCATGCTGTGGGAGAACAATTCGACGATCGTGGTGATGCTGACCAAGCTGCGGGAGATGGGCCGGGAGAA GTGTCACCAGTACTGGCCGGCCGAGCGCTCTGCCCGCTACCAGTACTTTGTGGTAGATCCGATGGCAGAATACAACATGCCTCAGTATATCCTGCGAGAG TTCAAGGTCACAGATGCCCGGGATGGCCAGTCCCGGACTGTCCGGCAGTTCCAGTTCACAGACTGGCCGGAACAGGGTGTGCCAAAGTCGGGGGAGGGCT TCATCGACTTCATTGGCCAAGTGCATAAGACTAAGGAGCAGTTTGGCCAGGACGGCCCCATCTCTGTCCACTGCAGTGCCGGCGTGGGCAGGACGGGCGT CTTCATCACGCTTAGCATCGTGCTGGAGCGGATGCGGTATGAAGGCGTGGTGGACATCTTTCAGACGGTGAAGATGCTACGAACCCAGCGGCCGGCCATG GTGCAGACAGAGGATGAGTACCAGTTCTGTTACCAGGCGGCACTGGAGTACCTCGGAAGCTTTGACCACTATGCAACCTAAAGCCATGGTTCCCCCCAGG CCCGACACCACTGGCCCCGGATGCCTCTGCCCCTCCCGGGCGGACCTCCTGAGGCCTGGACCCCCAGTGGGCAGGGCAGGAGGTGGCAGCGGCAGCAGCT GTGTTTCTGCACCATTTCCGAGGACGACGCAGCCCCTCGAGCCCCCCCACCGGCCCCGGCCGCCCCAGCGACCTCCCTGGCACCGGCCGCCGCCTTCAAA TACTTGGCACATTCCTCCTTTCCTTCCAATTCCAAAACCAGATTCCGGGGTGGGGGGTGGGGGGATGGTGAGCAAATAGGAGTGCTCCCCAGAACCAGAG GAGGGTGGGGCACAGACCATAGACGGACCCCTCGTCCTCCCCCAGCGGTGGTAGGGGGACCCGGGGGGCTCCTCCCCGCTCTGCAGC

refseq_PTPRS.F6 (forward primer)
refseq_PTPRS.R6 (reverse primer)
Single exon skipping

Frame 0

IPSHHPMILPHCPMTSPRRTLPCSM*PSLCLLH EGLLDFPTRLSQPSIVSADVAPSDARLEASL*GT GGPSPSRAEIGGRCQAWRPPGALAWCLWLVPWA SLWSCSLEAVQQKSPPGLSKNPRTRSACRGVWP LSCVRPRVTPSHE*PGTRRARRSTLSALRRLSLM RVQGQC*GSSR*GHRGMKTCTSVWPRTRLGRSQ SMPSLLSSERTSCPLASPTSTWAHS*RWWSGHG QPPCSVQPAATLTLRSPGSRTSCLWILVPAMDAS NSCDQEPCRLKAVRKPTRANMSVWPPTAPACAT PHLPTSTCESAAWPRASPSCP*ATRSCQGAT*T SPAWPWARPCHT*SGCRGPRT*PPRMTCPWVGTC WNSQMSRTRPTTPAWPCPAWASLRRLLRSR*NL SPKLPGLPW*LRTQPPASPSRGTRATQILCPIT SSNINPRAKTGRIRLKRTSPPHVTASAA*APTRS TRSGCRPSTPSARGPPASPWSPAQASRPRPARR GTCKPGCSARPP*LCSGRSRWSPTA*SAATAST TPWNRSTPWATGRSTTWTTAC*PPWAACWRTRPT PCGCSPSPPSATGPSRTPSRSRRSRECRASP*T CGPRPGRRPASRCPGAPRGRRVSSSTSSSSGKA TMAGRWEGPSTRRLPTWWRT*SPTRSTPSAWRPA RRRAWAPSPPWCGSARCSPNRQPPLKTLNVSAC APRPFW*VGARRRRKRTTGPWWATASATDRWAQ RTRNPRR*TASPRPPLRSCWRPWRSGPSTASRLS LTQRWDQGPRARPWSSAPTRMCPARRRGRWRRR RSTPRPSACCGARPRPAGSTARSAATRSTTCAW RAPRPAGRRASRTSCWPMPRRWSSQTCSLRPRTP SR*PPTP*RAMALAANPRWL*PREQCWAAQPCR CSRPPRAACWHAGSPRLAPRRTRCWATACSLAV RTRRPWPPWSSRPPRTATRHQACTRGPRMCSGLR PGAAAAWARRQPRS*ASRRTRPVATRRFWRRPA TPRPGPSFSAGCHPCPPSATGPSSNTRWPCGRP VPWALPERLSCRQRLSRARRTRSRCRA*SPTRPM TSKCEPTRAGALAPSAPPSATGRSCGTKSRPRT SR*K*S*RHQFCSAGSSLTTTTHPHPTRSSTMG SHWMWMAVPPRSSSRTSSPTPSTTLC*PIAAAAW AASSRRSPPGLPSTCSTASPASPPSLMLTASSW CIFLTARAPCLSRAISL*WCHCASLVEANS*PR WVAQRTWIWKSSSRTSHGYRGAACGTRVSWRCPG PILQLASLCCHPRSIPATRSSMAASITGAWSPA TAMSSSCLPCFRRASLPLQPVPSQTPSSWITRT PSPSWMARRGLSG*SGLCWPWSS*SALSLLSCST RTNPTVNARTQNPAPNAS*TMPTSPLTTPRTLW K*DALTSRLQACLATRQFPSQTWRSTRSGSRPT TASSSPRSMSPSTLDSSSHGNIPTWK*TSRRTAM PTSSPMTTPVSSSSPLKASWAVITSMPTTWTAT GVRTRTLPRRGRCLRPLGTSGVWCGSSGRRPSS **RGWRRSHGSSVISIGPTEARRPTASSRSRC*I PSSWPHSASGHSLCTRMAPVRNARSASSSLRRG RTMACPNTQRPSWLSCGESRPATRQMPAPSWFT AVPVWAAQAALSSSTPCLSGSSQRRQSMSMAT*R S*GPSATTWCRRRTSTASSTRPCWRPWAVATQK CPHAASMPTSRSWPRWSLANTSLAWNSSSSGWL TPRPTRHASSVPICLVTSSRTAW*TSCPMRAHGS VCNPSGVWRALTTSTPASLMATGSRRPTSRHRG RWRRPRKTSGACCGRTIRRSW*C*PSCGRWAGR SVTSTGRPSALPATSTLW*IRWQNTTCLSISCES SRSQMPGMASPGLSGSSSSQTGRNRVCQSRGRA SSTSLAKCIRLRSSLARTAPSLSTAVPAWAGRA SSSRLASCWSGCGMKAWWTSFRR*RCYEPSGRPW CRQRMSTSSVTRRHWSTSEALTTMQPKAMVPPR PDTTGPGCLCPSRADLLRPGPPVGRAGGGSGSS CVSAPFPRTTQPLEPPHRPRPPQRPPWHRPPPSN TWHIPPFLPIPKPDSGVGGGGMVSK*ECSPEPE EGGAQTIDGPLVLPQRW*GDPGGSSPLCS

Frame 1

FHPITP*SFPIVP*PAPAGPSPAPCDPPSASSM KVSWISPLASHSPPLSLQTLPHLTLGSRPLCEG PGGHPPPGRRSEVAAKHGAHLGPWHGVCGWSHGP PCGPARWRLCSRRAPQVYQRTQGPDRRVGGCGL FRVSGHG*PQATSDLEQEGQEGQLSAL*DD*V* *ECRGSAEDPAAEDTAG*KRVRVCGPELGWGDHS PCQAYCPPRGPAALWLPQHRHGPTVEGGGADTD SHHALCSQRQP*P*DHLVQGLPACGS*CQQWTH QTAAIRSPAD*KQ*GNRPGQI*VCGHQQRRRALL LTCQPLRASPPRGPALLHPAHEPRDHARGQREH HLRGRGLAHAIREVDAGGRGPDPRG*HARGSER AGTHRCQGLGQLHLRGHVQPGRH*GGCSDHGEIS PQSSRDSHGD*EHSHQHHHHVGLGQPRSCVLLR HRI*IQEPRRAVSD*RGHHHHTLQHRRPEPQLG VRDLGVGRQLHRPGAPQRVRGHPHRRAGPGQRAA ERASPDAQRDHHDCAVGGAGGAQRPDPRLPRLL HHGTGAPRGQLAEAQRGRQPADHRGQPAGGRDL HRAGARLHLRRRRAPLGPHPGQDAAGSAGPAHEP AGRGQVGDQHHAVLEPPAAGEYHQVRAPLPGRR PWPGGGKDLRPDDFLRGGGPEAQHGVRLPPGGP LAAGPGRLHPRGAAAHAAVQTVSPPSRR*MCQRA LHGHFGKLAPAAAGNAQRGPGGLQRPLPTAGLR GPGTQGGERHPPDHHSDPAGGLGEVDPVPHHDC RSHRGGTRARELARGRPHRRGCAQRAAAEGGGGG AQRHGHPRAVALARARPAARPDPRLPGPLRAHG GRRGPRAAAHQGRHAGRCPGDGHHKLAA*DRVL HHGSRLHHEGRWRSQQTQGGCDQGSSAGPPNPVG AADPRGQPAGTLGAPGWHRGGPGAGLPPAVWP* GLDAPGHPGVPALRGPLHGIRRAQGGHVCVPAC GPEPRRPGRGGSRGPEHPGGHAPWPPADSGGGRQ RLGRDRPSPLAATRARRAQRGHRQIHGGRAGGR CPGPCPRD*AAGSG*AGRGERAHAAGPEARHGL *PPSASPHAPGPWPLQPPRPLPDVPAGPSLAQEL QGENDHEDISSAQLGVP*QLQLTHTLQDPVQWA HTGCGWPYHQEAHHAPQAPHLLQLCADQSRQQP GRPPADGHRLDCLQPAQRQAQRRPQA*C*RLHHG VSS*RPEPRACPELFHCDGATAQVSWRPIPDPA G*PRGHGSGRAHPGHLTATEAQPAALASAGGAP ALYCSSLLCAATHVPSRRPEAVWRLR*PGPGARP PLCPLRACRASEERAYLCSQSLLRPLPAG*PGP PAHRGWRGGAYLGDRACAGRGLHNLHCHCYPAL QEQTRQ*TQGLRTPHQMPPEQCRPRPSPPQGPCG NETH*LPDSRHA*PPANSHRRHGGAHGAAQGQR QPQALPGV*VHRPWTAVHMGTFQPGSEQAEEPL CQRHRL*PLPCHPPAH*RHHGQ*LHQCQLRGRLP VSERVHCHAGAAA*DLWGLLAYGVGAAVGDHRH DDAAGGEVTDQV*SVLAQQRHGDLRLHPGHVAR YHRAGHILRQDILSAQEWLQ*ETRGPPVPVYGVA GPWRARIPNALPGFPAESQDLQPARCRPHRGSL QCRCGPHRLLYRHRRHA*ADQAREDSRCLWPRD AHEVPAQLHGADGGPVQLHPRGPAGGRGLWQHRS ARTQPLCLHPEAGPGGAWRTRHWHGTRVQAAG* LQGPHVTLHQCQSAL*QVQEPPGEHHAL*EHTG LSATHPGCGGL*LHQRQLH*WLQAAEGLHRDTGA AGGDHGRLLAHAVGEQFDDRGDADQAAGDGPGE VSPVLAGRALCPLPVLCGRSDGRIQHASVYPAR VQGHRCPGWPVPDCPAVPVHRLAGTGCAKVGGGL HRLHWPSA*D*GAVWPGRPHLCPLQCRRGQDGR LHHA*HRAGADAV*RRGGHLSDGEDATNPAAGH GADRG*VPVLLPGGTGVPRKL*PLCNLKPWFPPG PTPLAPDASAPPGRTS*GLDPQWAGQEVAAAAA VFLHHFRGRRSPSSPPTGPGRPSDLPGTGRRLQ ILGTFLLSFQFQNQIPGWGVGGW*ANRSAPQNQR RVGHRP*TDPSSSPSGGRGTRGAPPRSA

Frame 2

SIPSPHDPSPLSHDQPPQDPPLLHVTLPLPPP* RSPGFPHSPLTALHCLCRRCPI*RSARGLSVRD RGAIPLQGGDRRSLPSMAPTWGPGMVSVVGPMG LLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVAS FVCQATGDPKPRVTWNKKGKKVNSQRFETIEFD ESAGAVLRIQPLRTPRDENVYECVAQNSVGEIT VHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRT ATMLCAASGNPDPEITWFKDFLPVDPSASNGRI KQLRSGALQIESSEETDQGKYECVATNSAGVRY SSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNI TCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNV LELTDVKDSANYTCVAMSSLGVIEAVAQITVKS LPKAPGTPMVTENTATSITITWDSGNPDPVSYYV IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSE YEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYY TMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETY TVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMN LRAEARSETSITLSWSPPRQESIIKYELLFREGD HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAAR SPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSV RSTAILVSWRPPPPETHNGALVGYSVRYRPLGSE DPEPKEVNGIPPTTTQILLEALEKWTQYRITTV AHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAE ALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRME GAEARGPPRIKDVMLADAQEMVITNLQPETAYS ITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLS VQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGRE DSTPLATLEFPPSEDRYTASGVHKGATYVFRLA ARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAG NASAGTVLLRWLPPVPAERNGAIVKYTVAVREAG ALGPARETELPAAAEPGAENALTLQGLKPDTAY DLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKN FKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGL TLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSL GGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM VYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPL GSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPG HRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDP QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLY KNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPV EMRRINFQTPGMLSHPPIPIADMAEHTERLKAND SLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRY ANVIAYDHSRVILQPIEGIMGSDYINANYVDGY RCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD TIELATFCVRTFSLHKNGSSEKREVRQFQFTAW PDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHC SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVT LMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTE VPARSLYAYIQKLAQVEPGEHVTGMELEFKRLAN SKAHTSRFISANLPCNKFKNRLVNIMPYESTRV CLQPIRGVEGSDYINASFIDGYRQQKAYIATQG PLAETTEDFWRMLWENNSTIVVMLTKLREMGREK CHQYWPAERSARYQYFVVDPMAEYNMPQYILRE FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEG FIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAM VQTEDEYQFCYQAALEYLGSFDHYAT*SHGSPQ ARHHWPRMPLPLPGGPPEAWTPSGQGRRWQRQQL CFCTISEDDAAPRAPPPAPAAPATSLAPAAAFK YLAHSSFPSNSKTRFRGGGWGDGEQIGVLPRTR GGWGTDHRRTPRPPPAVVGGPGGLLPALQ

Sequence NM_002850

ATTCCATCCCATCACCCCATGATCCTTCCCCATTGTCCCATGACCAGCCCCCGCAGGACCCTCCCCTGCTCCATGTGACCCTCCCTCTGCCTCCTCCATG AAGGTCTCCTGGATTTCCCCACTCGCCTCTCACAGCCCTCCATTGTCTCTGCAGACGTTGCCCCATCTGACGCTCGGCTCGAGGCCTCTCTGTGAGGGAC CGGGGGGCCATCCCCCTCCAGGGCGGAGATCGGAGGTCGCTGCCAAGCATGGCGCCCACCTGGGGCCCTGGCATGGTGTCTGTGGTTGGTCCCATGGGCC TCCTTGTGGTCCTGCTCGTTGGAGGCTGTGCAGCAGAAGAGCCCCCCAGGTTTATCAAAGAACCCAAGGACCAGATCGGCGTGTCGGGGGGTGTGGCCTC TTTCGTGTGTCAGGCCACGGGTGACCCCAAGCCACGAGTGACCTGGAACAAGAAGGGCAAGAAGGTCAACTCTCAGCGCTTTGAGACGATTGAGTTTGAT GAGAGTGCAGGGGCAGTGCTGAGGATCCAGCCGCTGAGGACACCGCGGGATGAAAACGTGTACGAGTGTGTGGCCCAGAACTCGGTTGGGGAGATCACAG TCCATGCCAAGCTTACTGTCCTCCGAGAGGACCAGCTGCCCTCTGGCTTCCCCAACATCGACATGGGCCCACAGTTGAAGGTGGTGGAGCGGACACGGAC AGCCACCATGCTCTGTGCAGCCAGCGGCAACCCTGACCCTGAGATCACCTGGTTCAAGGACTTCCTGCCTGTGGATCCTAGTGCCAGCAATGGACGCATC AAACAGCTGCGATCAGAAACCTTTGAAAGCACTCCGATTCGAGGAGCCCTGCAGATTGAAAGCAGTGAGGAAACCGACCAGGGCAAATATGAGTGTGTGG CCACCAACAGCGCCGGCGTGCGCTACTCCTCACCTGCCAACCTCTACGTGCGAGAGCTTCGAGAAGTCCGCCGCGTGGCCCCGCGCTTCTCCATCCTGCC CATGAGCCACGAGATCATGCCAGGGGGCAACGTGAACATCACCTGCGTGGCCGTGGGCTCGCCCATGCCATACGTGAAGTGGATGCAGGGGGCCGAGGAC CTGACCCCCGAGGATGACATGCCCGTGGGTCGGAACGTGCTGGAACTCACAGATGTCAAGGACTCGGCCAACTACACCTGCGTGGCCATGTCCAGCCTGG GCGTCATTGAGGCGGTTGCTCAGATCACGGTGAAATCTCTCCCCAAAGCTCCCGGGACTCCCATGGTGACTGAGAACACAGCCACCAGCATCACCATCAC GTGGGACTCGGGCAACCCAGATCCTGTGTCCTATTACGTCATCGAATATAAATCCAAGAGCCAAGACGGGCCGTATCAGATTAAAGAGGACATCACCACC ACACGTTACAGCATCGGCGGCCTGAGCCCCAACTCGGAGTACGAGATCTGGGTGTCGGCCGTCAACTCCATCGGCCAGGGGCCCCCCAGCGAGTCCGTGG TCACCCGCACAGGCGAGCAGGCCCCGGCCAGCGCGCCGCGGAACGTGCAAGCCCGGATGCTCAGCGCGACCACCATGATTGTGCAGTGGGAGGAGCCGGT GGAGCCCAACGGCCTGATCCGCGGCTACCGCGTCTACTACACCATGGAACCGGAGCACCCCGTGGGCAACTGGCAGAAGCACAACGTGGACGACAGCCTG CTGACCACCGTGGGCAGCCTGCTGGAGGACGAGACCTACACCGTGCGGGTGCTCGCCTTCACCTCCGTCGGCGACGGGCCCCTCTCGGACCCCATCCAGG TCAAGACGCAGCAGGGAGTGCCGGGCCAGCCCATGAACCTGCGGGCCGAGGCCAGGTCGGAGACCAGCATCACGCTGTCCTGGAGCCCCCCGCGGCAGGA GAGTATCATCAAGTACGAGCTCCTCTTCCGGGAAGGCGACCATGGCCGGGAGGTGGGAAGGACCTTCGACCCGACGACTTCCTACGTGGTGGAGGACCTG AAGCCCAACACGGAGTACGCCTTCCGCCTGGCGGCCCGCTCGCCGCAGGGCCTGGGCGCCTTCACCCCCGTGGTGCGGCAGCGCACGCTGCAGTCCAAAC CGTCAGCCCCCCCTCAAGACGTTAAATGTGTCAGCGTGCGCTCCACGGCCATTTTGGTAAGTTGGCGCCCGCCGCCGCCGGAAACGCACAACGGGGCCCT GGTGGGCTACAGCGTCCGCTACCGACCGCTGGGCTCAGAGGACCCGGAACCCAAGGAGGTGAACGGCATCCCCCCGACCACCACTCAGATCCTGCTGGAG GCCTTGGAGAAGTGGACCCAGTACCGCATCACGACTGTCGCTCACACAGAGGTGGGACCAGGGCCCGAGAGCTCGCCCGTGGTCGTCCGCACCGACGAGG ATGTGCCCAGCGCGCCGCCGCGGAAGGTGGAGGCGGAGGCGCTCAACGCCACGGCCATCCGCGTGCTGTGGCGCTCGCCCGCGCCCGGCCGGCAGCACGG CCAGATCCGCGGCTACCAGGTCCACTACGTGCGCATGGAGGGCGCCGAGGCCCGCGGGCCGCCGCGCATCAAGGACGTCATGCTGGCCGATGCCCAGTGG GAGACGGATGACACGGCCGAATATGAGATGGTCATCACAAACTTGCAGCCTGAGACCGCGTACTCCATCACGGTAGCCGCCTACACCATGAAGGGCGATG GCGCTCGCAGCAAACCCAAGGTGGTTGTGACCAAGGGAGCAGTGCTGGGCCGCCCAACCCTGTCGGTGCAGCAGACCCCCGAGGGCAGCCTGCTGGCACG CTGGGAGCCCCCGGCTGGCACCGCGGAGGACCAGGTGCTGGGCTACCGCCTGCAGTTTGGCCGTGAGGACTCGACGCCCCTGGCCACCCTGGAGTTCCCG CCCTCCGAGGACCGCTACACGGCATCAGGCGTGCACAAGGGGGCCACGTATGTGTTCCGGCTTGCGGCCCGGAGCCGCGGCGGCCTGGGCGAGGAGGCAG CCGAGGTCCTGAGCATCCCGGAGGACACGCCCCGTGGCCACCCGCAGATTCTGGAGGCGGCCGGCAACGCCTCGGCCGGGACCGTCCTTCTCCGCTGGCT GCCACCCGTGCCCGCCGAGCGCAACGGGGCCATCGTCAAATACACGGTGGCCGTGCGGGAGGCCGGTGCCCTGGGCCCTGCCCGAGAGACTGAGCTGCCG GCAGCGGCTGAGCCGGGCGCGGAGAACGCGCTCACGCTGCAGGGCCTGAAGCCCGACACGGCCTATGACCTCCAAGTGCGAGCCCACACGCGCCGGGGCC CTGGCCCCTTCAGCCCCCCCGTCCGCTACCGGACGTTCCTGCGGGACCAAGTCTCGCCCAAGAACTTCAAGGTGAAAATGATCATGAAGACATCAGTTCT GCTCAGCTGGGAGTTCCCTGACAACTACAACTCACCCACACCCTACAAGATCCAGTACAATGGGCTCACACTGGATGTGGATGGCCGTACCACCAAGAAG CTCATCACGCACCTCAAGCCCCACACCTTCTACAACTTTGTGCTGACCAATCGCGGCAGCAGCCTGGGCGGCCTCCAGCAGACGGTCACCGCCTGGACTG CCTTCAACCTGCTCAACGGCAAGCCCAGCGTCGCCCCCAAGCCTGATGCTGACGGCTTCATCATGGTGTATCTTCCTGACGGCCAGAGCCCCGTGCCTGT CCAGAGCTATTTCATTGTGATGGTGCCACTGCGCAAGTCTCGTGGAGGCCAATTCCTGACCCCGCTGGGTAGCCCAGAGGACATGGATCTGGAAGAGCTC ATCCAGGACATCTCACGGCTACAGAGGCGCAGCCTGCGGCACTCGCGTCAGCTGGAGGTGCCCCGGCCCTATATTGCAGCTCGCTTCTCTGTGCTGCCAC CCACGTTCCATCCCGGCGACCAGAAGCAGTATGGCGGCTTCGATAACCGGGGCCTGGAGCCCGGCCACCGCTATGTCCTCTTCGTGCTTGCCGTGCTTCA GAAGAGCGAGCCTACCTTTGCAGCCAGTCCCTTCTCAGACCCCTTCCAGCTGGATAACCCGGACCCCCAGCCCATCGTGGATGGCGAGGAGGGGCTTATC TGGGTGATCGGGCCTGTGCTGGCCGTGGTCTTCATAATCTGCATTGTCATTGCTATCCTGCTCTACAAGAACAAACCCGACAGTAAACGCAAGGACTCAG AACCCCGCACCAAATGCCTCCTGAACAATGCCGACCTCGCCCCTCACCACCCCAAGGACCCTGTGGAAATGAGACGCATTAACTTCCAGACTCCAGATTC AGGCCTCAGGAGCCCCCTCAGGGAGCCGGGGTTTCACTTTGAAAGCATGCTTAGCCACCCGCCAATTCCCATCGCAGACATGGCGGAGCACACGGAGCGG CTCAAGGCCAACGACAGCCTCAAGCTCTCCCAGGAGTATGAGTCCATCGACCCTGGACAGCAGTTCACATGGGAACATTCCAACCTGGAAGTGAACAAGC CGAAGAACCGCTATGCCAACGTCATCGCCTATGACCACTCCCGTGTCATCCTCCAGCCCATTGAAGGCATCATGGGCAGTGATTACATCAATGCCAACTA CGTGGACGGCTACCGGTGTCAGAACGCGTACATTGCCACGCAGGGGCCGCTGCCTGAGACCTTTGGGGACTTCTGGCGTATGGTGTGGGAGCAGCGGTCG GCGACCATCGTCATGATGACGCGGCTGGAGGAGAAGTCACGGATCAAGTGTGATCAGTATTGGCCCAACAGAGGCACGGAGACCTACGGCTTCATCCAGG TCACGTTGCTAGATACCATCGAGCTGGCCACATTCTGCGTCAGGACATTCTCTCTGCACAAGAATGGCTCCAGTGAGAAACGCGAGGTCCGCCAGTTCCA GTTTACGGCGTGGCCGGACCATGGCGTGCCCGAATACCCAACGCCCTTCCTGGCTTTCCTGCGGAGAGTCAAGACCTGCAACCCGCCAGATGCCGGCCCC ATCGTGGTTCACTGCAGTGCCGGTGTGGGCCGCACAGGCTGCTTTATCGTCATCGACGCCATGCTTGAGCGGATCAAGCCAGAGAAGACAGTCGATGTCT ATGGCCACGTGACGCTCATGAGGTCCCAGCGCAACTACATGGTGCAGACGGAGGACCAGTACAGCTTCATCCACGAGGCCCTGCTGGAGGCCGTGGGCTG TGGCAACACAGAAGTGCCCGCACGCAGCCTCTATGCCTACATCCAGAAGCTGGCCCAGGTGGAGCCTGGCGAACACGTCACTGGCATGGAACTCGAGTTC AAGCGGCTGGCTAACTCCAAGGCCCACACGTCACGCTTCATCAGTGCCAATCTGCCTTGTAACAAGTTCAAGAACCGCCTGGTGAACATCATGCCCTATG AGAGCACACGGGTCTGTCTGCAACCCATCCGGGGTGTGGAGGGCTCTGACTACATCAACGCCAGCTTCATTGATGGCTACAGGCAGCAGAAGGCCTACAT CGCGACACAGGGGCCGCTGGCGGAGACCACGGAAGACTTCTGGCGCATGCTGTGGGAGAACAATTCGACGATCGTGGTGATGCTGACCAAGCTGCGGGAG ATGGGCCGGGAGAAGTGTCACCAGTACTGGCCGGCCGAGCGCTCTGCCCGCTACCAGTACTTTGTGGTAGATCCGATGGCAGAATACAACATGCCTCAGT ATATCCTGCGAGAGTTCAAGGTCACAGATGCCCGGGATGGCCAGTCCCGGACTGTCCGGCAGTTCCAGTTCACAGACTGGCCGGAACAGGGTGTGCCAAA GTCGGGGGAGGGCTTCATCGACTTCATTGGCCAAGTGCATAAGACTAAGGAGCAGTTTGGCCAGGACGGCCCCATCTCTGTCCACTGCAGTGCCGGCGTG GGCAGGACGGGCGTCTTCATCACGCTTAGCATCGTGCTGGAGCGGATGCGGTATGAAGGCGTGGTGGACATCTTTCAGACGGTGAAGATGCTACGAACCC AGCGGCCGGCCATGGTGCAGACAGAGGATGAGTACCAGTTCTGTTACCAGGCGGCACTGGAGTACCTCGGAAGCTTTGACCACTATGCAACCTAAAGCCA TGGTTCCCCCCAGGCCCGACACCACTGGCCCCGGATGCCTCTGCCCCTCCCGGGCGGACCTCCTGAGGCCTGGACCCCCAGTGGGCAGGGCAGGAGGTGG CAGCGGCAGCAGCTGTGTTTCTGCACCATTTCCGAGGACGACGCAGCCCCTCGAGCCCCCCCACCGGCCCCGGCCGCCCCAGCGACCTCCCTGGCACCGG CCGCCGCCTTCAAATACTTGGCACATTCCTCCTTTCCTTCCAATTCCAAAACCAGATTCCGGGGTGGGGGGTGGGGGGATGGTGAGCAAATAGGAGTGCT CCCCAGAACCAGAGGAGGGTGGGGCACAGACCATAGACGGACCCCTCGTCCTCCCCCAGCGGTGGTAGGGGGACCCGGGGGGCTCCTCCCCGCTCTGCAG C

refseq_PTPRS.F6 (forward primer)
refseq_PTPRS.R6 (reverse primer)
Single exon skipping

Frame 0

IPSHHPMILPHCPMTSPRRTLPCSM*PSLCLLH EGLLDFPTRLSQPSIVSADVAPSDARLEASL*GT GGPSPSRAEIGGRCQAWRPPGALAWCLWLVPWA SLWSCSLEAVQQKSPPGLSKNPRTRSACRGVWP LSCVRPRVTPSHE*PGTRRARRSTLSALRRLSLM RVQGQC*GSSR*GHRGMKTCTSVWPRTRLGRSQ SMPSLLSSERTSCPLASPTSTWAHS*RWWSGHG QPPCSVQPAATLTLRSPGSRTSCLWILVPAMDAS NSCDQKPLKALRFEEPCRLKAVRKPTRANMSVW PPTAPACATPHLPTSTCESFEKSAAWPRASPSC P*ATRSCQGAT*TSPAWPWARPCHT*SGCRGPRT *PPRMTCPWVGTCWNSQMSRTRPTTPAWPCPAW ASLRRLLRSR*NLSPKLPGLPW*LRTQPPASPS RGTRATQILCPITSSNINPRAKTGRIRLKRTSPP HVTASAA*APTRSTRSGCRPSTPSARGPPASPW SPAQASRPRPARRGTCKPGCSARPP*LCSGRSR WSPTA*SAATASTTPWNRSTPWATGRSTTWTTAC *PPWAACWRTRPTPCGCSPSPPSATGPSRTPSR SRRSRECRASP*TCGPRPGRRPASRCPGAPRGR RVSSSTSSSSGKATMAGRWEGPSTRRLPTWWRT* SPTRSTPSAWRPARRRAWAPSPPWCGSARCSPN RQPPLKTLNVSACAPRPFW*VGARRRRKRTTGP WWATASATDRWAQRTRNPRR*TASPRPPLRSCWR PWRSGPSTASRLSLTQRWDQGPRARPWSSAPTR MCPARRRGRWRRRRSTPRPSACCGARPRPAGST ARSAATRSTTCAWRAPRPAGRRASRTSCWPMPSG RRMTRPNMRWSSQTCSLRPRTPSR*PPTP*RAM ALAANPRWL*PREQCWAAQPCRCSRPPRAACWH AGSPRLAPRRTRCWATACSLAVRTRRPWPPWSSR PPRTATRHQACTRGPRMCSGLRPGAAAAWARRQ PRS*ASRRTRPVATRRFWRRPATPRPGPSFSAG CHPCPPSATGPSSNTRWPCGRPVPWALPERLSCR QRLSRARRTRSRCRA*SPTRPMTSKCEPTRAGA LAPSAPPSATGRSCGTKSRPRTSR*K*S*RHQF CSAGSSLTTTTHPHPTRSSTMGSHWMWMAVPPRS SSRTSSPTPSTTLC*PIAAAAWAASSRRSPPGL PSTCSTASPASPPSLMLTASSWCIFLTARAPCL SRAISL*WCHCASLVEANS*PRWVAQRTWIWKSS SRTSHGYRGAACGTRVSWRCPGPILQLASLCCH PRSIPATRSSMAASITGAWSPATAMSSSCLPCF RRASLPLQPVPSQTPSSWITRTPSPSWMARRGLS G*SGLCWPWSS*SALSLLSCSTRTNPTVNARTQ NPAPNAS*TMPTSPLTTPRTLWK*DALTSRLQI QASGAPSGSRGFTLKACLATRQFPSQTWRSTRSG SRPTTASSSPRSMSPSTLDSSSHGNIPTWK*TS RRTAMPTSSPMTTPVSSSSPLKASWAVITSMPT TWTATGVRTRTLPRRGRCLRPLGTSGVWCGSSGR RPSS**RGWRRSHGSSVISIGPTEARRPTASSR SRC*IPSSWPHSASGHSLCTRMAPVRNARSASS SLRRGRTMACPNTQRPSWLSCGESRPATRQMPAP SWFTAVPVWAAQAALSSSTPCLSGSSQRRQSMS MAT*RS*GPSATTWCRRRTSTASSTRPCWRPWA VATQKCPHAASMPTSRSWPRWSLANTSLAWNSSS SGWLTPRPTRHASSVPICLVTSSRTAW*TSCPM RAHGSVCNPSGVWRALTTSTPASLMATGSRRPT SRHRGRWRRPRKTSGACCGRTIRRSW*C*PSCGR WAGRSVTSTGRPSALPATSTLW*IRWQNTTCLS ISCESSRSQMPGMASPGLSGSSSSQTGRNRVCQ SRGRASSTSLAKCIRLRSSLARTAPSLSTAVPAW AGRASSSRLASCWSGCGMKAWWTSFRR*RCYEP SGRPWCRQRMSTSSVTRRHWSTSEALTTMQPKA MVPPRPDTTGPGCLCPSRADLLRPGPPVGRAGGG SGSSCVSAPFPRTTQPLEPPHRPRPPQRPPWHR PPPSNTWHIPPFLPIPKPDSGVGGGGMVSK*EC SPEPEEGGAQTIDGPLVLPQRW*GDPGGSSPLCS

Frame 1

FHPITP*SFPIVP*PAPAGPSPAPCDPPSASSM KVSWISPLASHSPPLSLQTLPHLTLGSRPLCEG PGGHPPPGRRSEVAAKHGAHLGPWHGVCGWSHGP PCGPARWRLCSRRAPQVYQRTQGPDRRVGGCGL FRVSGHG*PQATSDLEQEGQEGQLSAL*DD*V* *ECRGSAEDPAAEDTAG*KRVRVCGPELGWGDHS PCQAYCPPRGPAALWLPQHRHGPTVEGGGADTD SHHALCSQRQP*P*DHLVQGLPACGS*CQQWTH QTAAIRNL*KHSDSRSPAD*KQ*GNRPGQI*VCG HQQRRRALLLTCQPLRARASRSPPRGPALLHPA HEPRDHARGQREHHLRGRGLAHAIREVDAGGRG PDPRG*HARGSERAGTHRCQGLGQLHLRGHVQPG RH*GGCSDHGEISPQSSRDSHGD*EHSHQHHHH VGLGQPRSCVLLRHRI*IQEPRRAVSD*RGHHH HTLQHRRPEPQLGVRDLGVGRQLHRPGAPQRVRG HPHRRAGPGQRAAERASPDAQRDHHDCAVGGAG GAQRPDPRLPRLLHHGTGAPRGQLAEAQRGRQP ADHRGQPAGGRDLHRAGARLHLRRRRAPLGPHPG QDAAGSAGPAHEPAGRGQVGDQHHAVLEPPAAG EYHQVRAPLPGRRPWPGGGKDLRPDDFLRGGGP EAQHGVRLPPGGPLAAGPGRLHPRGAAAHAAVQT VSPPSRR*MCQRALHGHFGKLAPAAAGNAQRGP GGLQRPLPTAGLRGPGTQGGERHPPDHHSDPAG GLGEVDPVPHHDCRSHRGGTRARELARGRPHRRG CAQRAAAEGGGGGAQRHGHPRAVALARARPAAR PDPRLPGPLRAHGGRRGPRAAAHQGRHAGRCPV GDG*HGRI*DGHHKLAA*DRVLHHGSRLHHEGRW RSQQTQGGCDQGSSAGPPNPVGAADPRGQPAGT LGAPGWHRGGPGAGLPPAVWP*GLDAPGHPGVP ALRGPLHGIRRAQGGHVCVPACGPEPRRPGRGGS RGPEHPGGHAPWPPADSGGGRQRLGRDRPSPLA ATRARRAQRGHRQIHGGRAGGRCPGPCPRD*AA GSG*AGRGERAHAAGPEARHGL*PPSASPHAPGP WPLQPPRPLPDVPAGPSLAQELQGENDHEDISS AQLGVP*QLQLTHTLQDPVQWAHTGCGWPYHQE AHHAPQAPHLLQLCADQSRQQPGRPPADGHRLDC LQPAQRQAQRRPQA*C*RLHHGVSS*RPEPRAC PELFHCDGATAQVSWRPIPDPAG*PRGHGSGRA HPGHLTATEAQPAALASAGGAPALYCSSLLCAAT HVPSRRPEAVWRLR*PGPGARPPLCPLRACRAS EERAYLCSQSLLRPLPAG*PGPPAHRGWRGGAY LGDRACAGRGLHNLHCHCYPALQEQTRQ*TQGLR TPHQMPPEQCRPRPSPPQGPCGNETH*LPDSRF RPQEPPQGAGVSL*KHA*PPANSHRRHGGAHGA AQGQRQPQALPGV*VHRPWTAVHMGTFQPGSEQA EEPLCQRHRL*PLPCHPPAH*RHHGQ*LHQCQL RGRLPVSERVHCHAGAAA*DLWGLLAYGVGAAV GDHRHDDAAGGEVTDQV*SVLAQQRHGDLRLHPG HVARYHRAGHILRQDILSAQEWLQ*ETRGPPVP VYGVAGPWRARIPNALPGFPAESQDLQPARCRP HRGSLQCRCGPHRLLYRHRRHA*ADQAREDSRCL WPRDAHEVPAQLHGADGGPVQLHPRGPAGGRGL WQHRSARTQPLCLHPEAGPGGAWRTRHWHGTRV QAAG*LQGPHVTLHQCQSAL*QVQEPPGEHHAL* EHTGLSATHPGCGGL*LHQRQLH*WLQAAEGLH RDTGAAGGDHGRLLAHAVGEQFDDRGDADQAAG DGPGEVSPVLAGRALCPLPVLCGRSDGRIQHASV YPARVQGHRCPGWPVPDCPAVPVHRLAGTGCAK VGGGLHRLHWPSA*D*GAVWPGRPHLCPLQCRR GQDGRLHHA*HRAGADAV*RRGGHLSDGEDATNP AAGHGADRG*VPVLLPGGTGVPRKL*PLCNLKP WFPPGPTPLAPDASAPPGRTS*GLDPQWAGQEV AAAAAVFLHHFRGRRSPSSPPTGPGRPSDLPGTG RRLQILGTFLLSFQFQNQIPGWGVGGW*ANRSA PQNQRRVGHRP*TDPSSSPSGGRGTRGAPPRSA

Frame 2

SIPSPHDPSPLSHDQPPQDPPLLHVTLPLPPP* RSPGFPHSPLTALHCLCRRCPI*RSARGLSVRD RGAIPLQGGDRRSLPSMAPTWGPGMVSVVGPMG LLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVAS FVCQATGDPKPRVTWNKKGKKVNSQRFETIEFD ESAGAVLRIQPLRTPRDENVYECVAQNSVGEIT VHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRT ATMLCAASGNPDPEITWFKDFLPVDPSASNGRI KQLRSETFESTPIRGALQIESSEETDQGKYECV ATNSAGVRYSSPANLYVRELREVRRVAPRFSILP MSHEIMPGGNVNITCVAVGSPMPYVKWMQGAED LTPEDDMPVGRNVLELTDVKDSANYTCVAMSSL GVIEAVAQITVKSLPKAPGTPMVTENTATSITIT WDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESV VTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSL LTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQ VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQE SIIKYELLFREGDHGREVGRTFDPTTSYVVEDL KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSK PSAPPQDVKCVSVRSTAILVSWRPPPPETHNGAL VGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLE ALEKWTQYRITTVAHTEVGPGPESSPVVVRTDE DVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG QIRGYQVHYVRMEGAEARGPPRIKDVMLADAQW ETDDTAEYEMVITNLQPETAYSITVAAYTMKGD GARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR WEPPAGTAEDQVLGYRLQFGREDSTPLATLEFP PSEDRYTASGVHKGATYVFRLAARSRGGLGEEA AEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWL PPVPAERNGAIVKYTVAVREAGALGPARETELP AAAEPGAENALTLQGLKPDTAYDLQVRAHTRRG PGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVL LSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKK LITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWT AFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPV QSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEEL IQDISRLQRRSLRHSRQLEVPRPYIAARFSVLP PTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQ KSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLI WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDS GLRSPLREPGFHFESMLSHPPIPIADMAEHTER LKANDSLKLSQEYESIDPGQQFTWEHSNLEVNK PKNRYANVIAYDHSRVILQPIEGIMGSDYINANY VDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS ATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQ VTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQ FTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGP IVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDV YGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGC GNTEVPARSLYAYIQKLAQVEPGEHVTGMELEF KRLANSKAHTSRFISANLPCNKFKNRLVNIMPY ESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYI ATQGPLAETTEDFWRMLWENNSTIVVMLTKLRE MGREKCHQYWPAERSARYQYFVVDPMAEYNMPQ YILREFKVTDARDGQSRTVRQFQFTDWPEQGVPK SGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGV GRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT QRPAMVQTEDEYQFCYQAALEYLGSFDHYAT*SH GSPQARHHWPRMPLPLPGGPPEAWTPSGQGRRW QRQQLCFCTISEDDAAPRAPPPAPAAPATSLAP AAAFKYLAHSSFPSNSKTRFRGGGWGDGEQIGVL PRTRGGWGTDHRRTPRPPPAVVGGPGGLLPALQ