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Sequences

Sequence NM_015192

CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTCAAGTGGGATG ATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCT CAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAAGGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAG CAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGTGAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATG AGGTTTTCAGTTTGGCAACAAACCTGCTGGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGA AGGGCGTATTCCTCTCAAAAACATATATCGCTTGTTTTCAGCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAAT GATTCAATACCTCAAGAAGATTTCACTCCAGAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATTTG GTGCAAAAAGCAAACCATATCTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACTTTATCCACCTCT AAAACAAGAGCAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGTGGATGGGTTCATGCGCTATCTG AGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCCTCGCACAACA CCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAA GGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTTTCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCA TTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTG GGGATGCCCTTCTCATGGAGCCCCTGGAAAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAA TAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCC TCATCCCCAGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGGGACTGCTGGAAGTG AGGCTATGGCCACAGAAGAAATGTCTAATCTGGTGAACTATATTCAGCCAGTCAAGTTTGAGTCATTTGAAATTTCAAAAAAAAGAAATAAAAGTTTTGA AATGTCTTCCTTCGTGGAAACCAAAGGACTTGAACAACTCACCAAGTCTCCAGTGGAATTTGTAGAATATAACAAAATGCAGCTTAGCAGGATATATCCA AAAGGAACACGTGTGGATTCATCCAACTATATGCCTCAGCTCTTCTGGAATGCAGGTTGTCAGATGGTGGCACTTAATTTCCAGACAATGGACCTGGCTA TGCAAATAAATATGGGGATGTATGAATACAACGGGAAGAGTGGCTACAGATTGAAGCCAGAGTTCATGAGGAGGCCTGACAAGCATTTTGATCCATTTAC TGAAGGCATCGTAGATGGGATAGTGGCAAACACTTTGTCTGTTAAGATTATTTCAGGTCAGTTTCTTTCTGATAAGAAAGTTGGGACTTACGTGGAAGTA GATATGTTTGGTTTGCCTGTGGATACAAGGAGGAAGGCATTTAAGACCAAAACATCCCAAGGAAATGCTGTGAATCCTGTCTGGGAAGAAGAACCTATTG TGTTCAAAAAGGTGGTTCTTCCTACTCTGGCCTGTTTGAGAATAGCAGTTTATGAAGAAGGAGGTAAATTCATTGGCCACCGTATCTTGCCAGTGCAAGC CATTCGGCCAGGCTATCACTATATCTGTCTAAGGAATGAAAGGAACCAGCCTCTGACGCTGCCTGCTGTCTTTGTCTACATAGAAGTGAAAGACTATGTG CCAGACACATATGCAGATGTCATCGAAGCTTTATCAAACCCAATCCGATATGTGAACCTGATGGAACAGAGAGCTAAGCAATTGGCTGCTTTGACACTGG AAGATGAAGAAGAAGTAAAGAAAGAGGCTGATCCTGGAGAAACACCATCAGAGGCTCCAAGTGAAGCGAGAACGACTCCAGCAGAAAATGGGGTGAATCA CACTACAACCCTGACACCCAAGCCACCCTCCCAGGCTCTCCACAGCCAGCCAGCTCCAGGTTCTGTAAAGGCACCTGCCAAAACAGAAGATCTTATTCAG AGTGTCTTAACAGAAGTGGAAGCACAGACCATCGAAGAACTAAAGCAACAGAAATCGTTTGTGAAACTTCAAAAGAAACACTACAAAGAAATGAAAGACC TGGTTAAGAGACACCACAAGAAAACCACTGACCTTATCAAAGAACACACTACCAAGTATAATGAAATTCAGAATGACTACTTGAGAAGGAGAGCCGCTTT GGAAAAGTCCGCCAAAAAGGACAGTAAGAAAAAATCGGAACCCAGCAGCCCTGATCATGGTTCATCAACGATTGAGCAAGACCTCGCTGCTCTGGATGCT GAAATGACCCAAAAGTTAATAGACTTGAAGGACAAACAACAGCAGCAGCTGCTTAATCTTCGGCAAGAACAGTATTATAGTGAAAAATACCAGAAGCGAG AACATATTAAACTGCTTATTCAAAAGTTGACGGATGTCGCAGAAGAGTGTCAGAACAATCAGTTAAAGAAGCTCAAAGAAATCTGTGAGAAAGAAAAGAA AGAATTAAAGAAGAAAATGGATAAAAAGAGGCAGGAGAAGATAACAGAAGCTAAATCCAAAGACAAAAGTCAGATGGAAGAGGAGAAGACAGAGATGATC CGGTCATATATCCAGGAAGTGGTGCAGTATATCAAGAGGCTAGAAGAAGCGCAAAGTAAACGGCAAGAAAAACTCGTAGAGAAACACAAGGAAATACGTC AGCAGATCCTGGATGAAAAGCCCAAGCTGCAGGTGGAGCTGGAGCAAGAATACCAAGACAAATTCAAAAGACTGCCCCTCGAGATTTTGGAATTCGTGCA GGAAGCCATGAAAGGAAAGATCAGTGAAGACAGCAATCACGGTTCTGCCCCTCTCTCCCTGTCCTCAGACCCTGGAAAAGTGAACCACAAGACTCCCTCC AGTGAGGAGCTGGGAGGAGACATCCCAGGAAAAGAATTTGATACTCCTCTGTGAATGCTCCTGCCAGGCCTTCAGAAATTGCATGGCCACTCCAGCGTCA TCGGACTCTCTCTTATTACAAAGATCACTGCCCAGGACCATCTTCCCGAGAAGCATCCCTTAGCCTAAAATCCACACCAAAGGGAGAGTTCCAGAGGAAT CCATGAAGAATTCCCATGCCCAGGCTCCATGTGTCATGTGGAAACCTCCACAGGTCTGCTAGTGAAGAATGCATGTATGTGAGATTTTTGTTTTCTTTCC AATAGCAAATTCAAAGCAAGCAACTTGCAGGCTCCATGGAACTTTTAATGAAGGACAGTGTCTTCTTTGAAGAAAATCAAGCTCGTGTTTTTATTCGAAG CTCTGGTGTAAAATATTTCAAAGTCATAGAAATAGTTTGAGAAATGCATAGCATTATTTAACACTATTGAACAGCCGACTTTGAGCATTGTTTCTTCTAA CTGCCCCTCAACTACCATTATCTTCAAGTCAACATGCATATTACATTTTCATCCTTTGCTTTGCAAGCACTGGTGGCTTGCAGTTTGCTAATTTATTTAT CATAGAGTCATCAATGTATTTGTTGCTGACATGGTTTTATTAGATACTGTAGTGATTCAAATAAGTTTTCTATTTGAAAAAAAAAATCACTTGATTGTAT CCTTGCCCAGTGAAGCCATCCTAAGACTTAGCAATATGGATTGTACATTTGGCTGCATGAGCAAGTCGGCCGCACACTTCCAGACAGTGTGCTGTTTGAA TTGACTATTTGCACTCAAAGTCTGGGTATTCATTGGTTATTGGCCTGAAATGATCAAATAACTACAAATGATCTGTTGAATAAAAATAGTTGAGCTGATA TATGTTAAGCAGATATTCAATCAGAATGAACAGGTTCCGGTGGTTATTTTGCCGTTTGACATTTTTTATGGTTCATTTATTTTTAATATAGAGAGGAAGA TTGAATATTTATCTAGAGAATACAAAGACCCACATGTAAATGATAGGTATTATCTCCATGTATATATGTACCCACTTAGTCATGTAAGTGCATATACACA TACACACACATGAGTGTAGACATGTGTTTATTAATTGACAATGACCCAAATCTCTTCCACAAGACTTAAAACCAAATTCAGGGACAAATGGATAGAGAAG AAAAGGGTCAAACATCGAGATTACATGGATGTTAAATTATATGGAGACGCTAAGAAATAATTGATGGAGCCATTGATGCAAACCGAAGTAGATTTAGAAC TTATATGAATTTGATTTATATTTTGCAAGATCAAAAATTAGATGTTAAGTATCAGATTTTAAGCTTGTTTTAATGGTCAAAAAATTAGGACAGAAATAAT ATGGACATTTATTAGTATCTTCCATAATTTTTAAGTCTGACACATTTCTATTTTATTCTAACATAAAAAAACTTCCATTATATATTTACTAAGTATATTT AATTCACTTAACTCTGTCTTTATAAGTTCCTATTTTAGATGGAATAAGAGAAACAAATTATATCAAGGTAAAACTGATCAAAAGCATAATTGAAAGTTCT GAAAAAAGAAAAATAATAATATGTAGAAAAATGTAACTTAGAGAGTAACACATGAACATTGAAGTTAAAACCCAGAAGCCAGATGCTCACAGTTTTATTT TACTTTAAAATAAACCTGTCTGACTGTAGCTTTGTGAAATATCTTAAAACGCAAAAACCAATTGTGTCCTGAAAATTGTTTCAAGAATTTAATATTTTTA TGAAAATTATTTTATTTAACTTTAAGCAATAACTAGAGATTACAATTAAATTTTAATCAAAATGAAGGCTTAGTTCAAACATAAGGAAACAGTGTTTGAT TAAAAAAAACACATCTAGTAAGACGTAAGGGGAAAATCACATCCTCTTTGGAGATGATTATATTTTGATCTGAAGGGTTTGGGGTGTTCATTAGACACTT AATAAAACTTAACTTCCAATGAAAAAGAAATCTTTTGTAAATCATTCTACTTTTGCACTTTGAAAGAAAGGCGTTAATCATAAAGAAGCAAGAATGGTCA AAATCGAATGCTGCATTTTTATAAACAAAATTACAGACTGTCTGAAATTGAAGAAGAATGAACTAATAATAGCATTCATAACCAAACACAATGATGATTA TTGCAGAACATTGTATCACATTTTAGTCCAGAGATAGAATAAAGTTGAATAACCTTGACTTACACAAAACTGTTTTGGTAGTTGGATTTCATTATCTTAG TGAATTTAGTCATTTTACAATATGTTTGTATTTGGCCATTTACTGTAATCACATTTTTATATCTGTACAATGACACTTTTTGCAGTTGTGGGGTAGTGTG TAACACTGTCCATCTTGCATCATTGAAACTACTACAATGATACTATCATTTAATAATATTAATATTACTTGAAATAGACTAAGATAAAGAAAAGGGGTCT GTATGATGTGCAGTTTTGTGCCTTTATGTATTTGCCTTGTTCTTTGTCGAATGTGTGAAATTCCGTACTGTGGTTTTTCCTATAATAGAAAGTAGAGCTG TGTATTAAATTAGACTGTGTCTCTCTGATACCTTTACACTACTGAGAATAGCATGGTTTTGGCCATGTAAACCAATTTTCAAAGTTCTAATGACATAGCC ATGTGTTTTTGGTTTTTTATATTTCATTTTAAAATTTGAGTATCACCATACATTAATTAATACTCCTGTAGTAGATAAGCTGTCATTAAGTAATTCCCAA AAAAAGGGCCATTTGCTTGCATTACTTTGAATTTAATGTTGCGCTTGTGCACTGTGTTAATATTGTTTGTGATGGATTGGACGTTGTGACTCTTGCCTTT TAAGAAGAAAAAAAAGATAGGACAAAGTATTTGAAGCTCTTAAAATGTACATATTTTGGTTCTTCTATCTCAAATTATTTAAAATGCATAATTCACATTT TTGTAATAATTCTATGCAATTTTGTGGCATGATGTTTCTTCCACTTGTAATTTTATGTGCTTTCATCACAAATCCAAAGGAAAGAATAAAAATTTCTTAA CACAA

refseq_PLCB1.F1 (forward primer)
refseq_PLCB1.R1 (reverse primer)
Single exon skipping

Frame 0

QMAGAQPGVHALQLKPVCVSDSLKKGTKFVKWD DDSTIVTPIILRTDPQGFFFYWTDQNKETELLDL SLVKDARCGRHAKAPKDPKLRELLDVGNIGRLE QRMITVVYGPDLVNISHLNLVAFQEEVAKEWTN EVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPE GRIPLKNIYRLFSADRKRVETALEACSLPSSRN DSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEF GAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPL KQEQVQVLIEKYEPNNSLARKGQISVDGFMRYL SGEENGVVSPEKLDLNEDMSQPLSHYFINSSHN TYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWK GRTAEEEPVITHGFTMTTEISFKEVIEAIAECA FKTSPFPILLSFENHVDSPKQQAKMAEYCRLIF GDALLMEPLEKYPLESGVPLPSPMDLMYKILVKN KKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEP SSPGAGEADTESDDDDDDDDCKKSSMDEGTAGS EAMATEEMSNLVNYIQPVKFESFEISKKRNKSFE MSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYP KGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLA MQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFT EGIVDGIVANTLSVKIISGQFLSDKKVGTYVEV DMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPI VFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQA IRPGYHYICLRNERNQPLTLPAVFVYIEVKDYV PDTYADVIEALSNPIRYVNLMEQRAKQLAALTL EDEEEVKKEADPGETPSEAPSEARTTPAENGVNH TTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQ SVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKD LVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAAL EKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDA EMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKR EHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKK ELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMI RSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIR QQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQ EAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPS SEELGGDIPGKEFDTPL*MLLPGLQKLHGHSSV IGLSLITKITAQDHLPEKHPLA*NPHQRESSRGI HEEFPCPGSMCHVETSTGLLVKNACM*DFCFLS NSKFKASNLQAPWNF**RTVSSLKKIKLVFLFE ALV*NISKS*K*FEKCIALFNTIEQPTLSIVSSN CPSTTIIFKSTCILHFHPLLCKHWWLAVC*FIY HRVINVFVADMVLLDTVVIQISFLFEKKNHLIV SLPSEAILRLSNMDCTFGCMSKSAAHFQTVCCLN *LFALKVWVFIGYWPEMIK*LQMIC*IKIVELI YVKQIFNQNEQVPVVILPFDIFYGSFIFNIERK IEYLSREYKDPHVNDRYYLHVYMYPLSHVSAYTH THT*V*TCVY*LTMTQISSTRLKTKFRDKWIEK KRVKHRDYMDVKLYGDAKK*LMEPLMQTEVDLE LI*I*FIFCKIKN*MLSIRF*ACFNGQKIRTEII WTFISIFHNF*V*HISILF*HKKTSIIYLLSIF NSLNSVFISSYFRWNKRNKLYQGKTDQKHN*KF *KKKNNNM*KNVT*RVTHEH*S*NPEARCSQFYF TLK*TCLTVAL*NILKRKNQLCPENCFKNLIFL *KLFYLTLSNN*RLQLNFNQNEGLVQT*GNSV* LKKTHLVRRKGKITSSLEMIIF*SEGFGVFIRHL IKLNFQ*KRNLL*IILLLHFERKALIIKKQEWS KSNAAFL*TKLQTV*N*RRMN***HS*PNTMMI IAEHCITF*SRDRIKLNNLDLHKTVLVVGFHYLS EFSHFTICLYLAIYCNHIFISVQ*HFLQLWGSV *HCPSCIIETTTMILSFNNINIT*NRLR*RKGV CMMCSFVPLCICLVLCRMCEIPYCGFSYNRK*SC VLN*TVSL*YLYTTENSMVLAM*TNFQSSNDIA MCFWFFIFHFKI*VSPYIN*YSCSR*AVIK*FP KKGPFACITLNLMLRLCTVLILFVMDWTL*LLPF KKKKKIGQSI*SS*NVHILVLLSQII*NA*FTF L**FYAILWHDVSSTCNFMCFHHKSKGKNKNFL TQ

Frame 1

RWPGLNPECTPCNSSPCACPTASRRAPNSSSGM MTQLLLLQLF*GLTLRDFSFTGQIKTRRQSYWI SALSKMPDVGDTPKLPRTPNYVNFWMWGTSGAWS SA*SQWCMGLTS*TSPI*ISWLSKKKWPRNGQM RFSVWQQTCWPKTCPGMHFWKKPILNLSCKSLQ KGVFLSKTYIACFQQIGSELKLL*RLVVFHLQGM IQYLKKISLQKCTEFSSTTFALDLKLITSFQNL VQKANHILPLIR*WILSTLSSEILGLMKYFIHL *NKSKSKY*LRSMNPTTASPEKDKYQWMGSCAI* VEKKTESFHLRNWI*MKTCLSPFLTISLIPRTT PTSQLANWLETPLLRCIAKCSCLVVAVWSWTAG RDGLQKRNLSSPMASP*QLKYLSRK**KQLRSVH LRLHLFQFSFRLRTMWIPQSSKPRWRSTAD*SL GMPFSWSPWKNIHWNLEFLFQALWI*CIKFW*K IRRNHTSHQKEAAKRSSQNKPPTPTVTPPACSSP HPQEPEKLIRKVTTTMMMMTVKNLQWMRGLLEV RLWPQKKCLIW*TIFSQSSLSHLKFQKKEIKVL KCLPSWKPKDLNNSPSLQWNL*NITKCSLAGYIQ KEHVWIHPTICLSSSGMQVVRWWHLISRQWTWL CK*IWGCMNTTGRVATD*SQSS*GGLTSILIHL LKAS*MG*WQTLCLLRLFQVSFFLIRKLGLTWK* ICLVCLWIQGGRHLRPKHPKEML*ILSGKKNLL CSKRWFFLLWPV*E*QFMKKEVNSLATVSCQCK PFGQAITISV*GMKGTSL*RCLLSLST*K*KTMC QTHMQMSSKLYQTQSDM*T*WNRELSNWLL*HW KMKKK*RKRLILEKHHQRLQVKRERLQQKMG*I TLQP*HPSHPPRLSTASQLQVL*RHLPKQKILFR VS*QKWKHRPSKN*SNRNRL*NFKRNTTKK*KT WLRDTTRKPLTLSKNTLPSIMKFRMTT*EGEPL WKSPPKRTVRKNRNPAALIMVHQRLSKTSLLWML K*PKS**T*RTNNSSSCLIFGKNSIIVKNTRSE NILNCLFKS*RMSQKSVRTIS*RSSKKSVRKKR KN*RRKWIKRGRRR*QKLNPKTKVRWKRRRQR*S GHISRKWCSISRG*KKRKVNGKKNS*RNTRKYV SRSWMKSPSCRWSWSKNTKTNSKDCPSRFWNSC RKP*KERSVKTAITVLPLSPCPQTLEK*TTRLPP VRSWEETSQEKNLILLCECSCQAFRNCMATPAS SDSLLLQRSLPRTIFPRSIP*PKIHTKGRVPEE SMKNSHAQAPCVMWKPPQVC**RMHVCEIFVFFP IANSKQATCRLHGTFNEGQCLL*RKSSSCFYSK LWCKIFQSHRNSLRNA*HYLTLLNSRL*ALFLL TAPQLPLSSSQHAYYIFILCFASTGGLQFANLFI IESSMYLLLTWFY*IL**FK*VFYLKKKIT*LY PCPVKPS*DLAIWIVHLAA*ASRPHTSRQCAV* IDYLHSKSGYSLVIGLK*SNNYK*SVE*K*LS*Y MLSRYSIRMNRFRWLFCRLTFFMVHLFLI*RGR LNIYLENTKTHM*MIGIISMYICTHLVM*VHIH IHTHECRHVFIN*Q*PKSLPQDLKPNSGTNG*RR KGSNIEITWMLNYMETLRNN*WSH*CKPK*I*N LYEFDLYFARSKIRC*VSDFKLVLMVKKLGQK* YGHLLVSSIIFKSDTFLFYSNIKKLPLYIY*VYL IHLTLSL*VPILDGIRETNYIKVKLIKSIIESS EKRKIIICRKM*LRE*HMNIEVKTQKPDAHSFI LL*NKPV*L*LCEIS*NAKTNCVLKIVSRI*YFY ENYFI*L*AITRDYN*ILIKMKA*FKHKETVFD *KKHI**DVRGKSHPLWR*LYFDLKGLGCSLDT **NLTSNEKEIFCKSFYFCTLKERR*S*RSKNGQ NRMLHFYKQNYRLSEIEEE*TNNSIHNQTQ**L LQNIVSHFSPEIE*S*ITLTYTKLFW*LDFIIL VNLVILQYVCIWPFTVITFLYLYNDTFCSCGVVC NTVHLASLKLLQ*YYHLIILILLEID*DKEKGS V*CAVLCLYVFALFFVECVKFRTVVFPIIESRA VY*IRLCLSDTFTLLRIAWFWPCKPIFKVLMT*P CVFGFLYFILKFEYHHTLINTPVVDKLSLSNSQ KKGHLLALL*I*CCACALC*YCL*WIGRCDSCL LRRKKR*DKVFEALKMYIFWFFYLKLFKMHNSHF CNNSMQFCGMMFLPLVILCAFITNPKERIKIS* H

Frame 2

DGRGSTRSARLATQARVRVRQPQEGHQIRQVG* *LNYCYSNYFED*PSGIFLLLDRSKQGDRATGS QPCQRCQMWETRQSSQGPQIT*TFGCGEHRAPG AAHDHSGVWA*PREHLPFESRGFPRRSGQGMDK* GFQFGNKPAGPKHVQGCISGKSLY*T*AASHSR RAYSSQKHISLVFSRSEAS*NCFRGL*SSIFKE *FNTSRRFHSRSVQSFPQQPLPST*N**HLFRIW CKKQTISYR*SDDGFYQP*AARSSA**NTLSTS KTRASPSID*EV*TQQQPRQKRTNISGWVHALS EWRRKRSRFT*ETGFE*RHVSAPFSLFH*FLAQH LPHSWPTGWKLLC*DVSPSAPVWLSLCGAGLLE GTDCRRGTCHHPWLHHDN*NIFQGSDRSNCGVC I*DFTFSNSPFV*EPCGFPKAASQDGGVLPTDLW GCPSHGAPGKISTGIWSSSSKPYGFNV*NFGEK *EEITQVIRRKRQKEALRTSLQHLQ*LLQHVRA LIPRSRRS*YGK*RRR****L*KIFNG*GDCWK* GYGHRRNV*SGELYSASQV*VI*NFKKKK*KF* NVFLRGNQRT*TTHQVSSGICRI*QNAA*QDIS KRNTCGFIQLYASALLECRLSDGGT*FPDNGPGY ANKYGDV*IQREEWLQIEARVHEEA*QAF*SIY *RHRRWDSGKHFVC*DYFRSVSF**ESWDLRGS RYVWFACGYKEEGI*DQNIPRKCCESCLGRRTYC VQKGGSSYSGLFENSSL*RRR*IHWPPYLASAS HSARLSLYLSKE*KEPASDAACCLCLHRSERLC ARHICRCHRSFIKPNPICEPDGTES*AIGCFDTG R*RRSKERG*SWRNTIRGSK*SENDSSRKWGES HYNPDTQATLPGSPQPASSRFCKGTCQNRRSYS ECLNRSGSTDHRRTKATEIVCETSKETLQRNERP G*ETPQENH*PYQRTHYQV**NSE*LLEKESRF GKVRQKGQ*EKIGTQQP*SWFIND*ARPRCSGC *NDPKVNRLEGQTTAAAA*SSARTVL**KIPEAR TY*TAYSKVDGCRRRVSEQSVKEAQRNL*ERKE RIKEENG*KEAGEDNRS*IQRQKSDGRGEDRDD PVIYPGSGAVYQEARRSAK*TARKTRRETQGNTS ADPG*KAQAAGGAGARIPRQIQKTAPRDFGIRA GSHERKDQ*RQQSRFCPSLPVLRPWKSEPQDSL Q*GAGRRHPRKRI*YSSVNAPARPSEIAWPLQRH RTLSYYKDHCPGPSSREASLSLKSTPKGEFQRN P*RIPMPRLHVSCGNLHRSASEECMYVRFLFSF Q*QIQSKQLAGSMELLMKDSVFFEENQARVFIRS SGVKYFKVIEIV*EMHSII*HY*TADFEHCFF* LPLNYHYLQVNMHITFSSFALQALVACSLLIYL S*SHQCICC*HGFIRYCSDSNKFSI*KKKSLDCI LAQ*SHPKT*QYGLYIWLHEQVGRTLPDSVLFE LTICTQSLGIHWLLA*NDQITTNDLLNKNS*AD IC*ADIQSE*TGSGGYFAV*HFLWFIYF*YREED *IFI*RIQRPTCK**VLSPCIYVPT*SCKCIYT YTHMSVDMCLLIDNDPNLFHKT*NQIQGQMDRE EKGQTSRLHGC*IIWRR*EIIDGAIDANRSRFRT YMNLIYILQDQKLDVKYQILSLF*WSKN*DRNN MDIY*YLP*FLSLTHFYFILT*KNFHYIFTKYI *FT*LCLYKFLF*ME*EKQIISR*N*SKA*LKVL KKEK**YVEKCNLESNT*TLKLKPRSQMLTVLF YFKINLSDCSFVKYLKTQKPIVS*KLFQEFNIF MKIILFNFKQ*LEITIKF*SK*RLSSNIRKQCLI KKNTSSKT*GENHILFGDDYILI*RVWGVH*TL NKT*LPMKKKSFVNHSTFAL*KKGVNHKEARMV KIECCIFINKITDCLKLKKNELIIAFITKHNDDY CRTLYHILVQR*NKVE*P*LTQNCFGSWISLS* *I*SFYNMFVFGHLL*SHFYICTMTLFAVVG*C VTLSILHH*NYYNDTII**Y*YYLK*TKIKKRGL YDVQFCAFMYLPCSLSNV*NSVLWFFL**KVEL CIKLDCVSLIPLHY*E*HGFGHVNQFSKF**HS HVFLVFYISF*NLSITIH*LILL**ISCH*VIPK KRAICLHYFEFNVALVHCVNIVCDGLDVVTLAF *EEKKDRTKYLKLLKCTYFGSSISNYLKCIIHI FVIILCNFVA*CFFHL*FYVLSSQIQRKE*KFLN T

Sequence NM_182734

CAGATGGCCGGGGCTCAACCCGGAGTGCACGCCTTGCAACTCAAGCCCGTGTGCGTGTCCGACAGCCTCAAGAAGGGCACCAAATTCGTCAAGTGGGATG ATGACTCAACTATTGTTACTCCAATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAGGAGACAGAGCTACTGGATCT CAGCCTTGTCAAAGATGCCAGATGTGGGAGACACGCCAAAGCTCCCAAGGACCCCAAATTACGTGAACTTTTGGATGTGGGGAACATCGGGCGCCTGGAG CAGCGCATGATCACAGTGGTGTATGGGCCTGACCTCGTGAACATCTCCCATTTGAATCTCGTGGCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATG AGGTTTTCAGTTTGGCAACAAACCTGCTGGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAAGCCTATACTAAACTTAAGCTGCAAGTCACTCCAGA AGGGCGTATTCCTCTCAAAAACATATATCGCTTGTTTTCAGCAGATCGGAAGCGAGTTGAAACTGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAAT GATTCAATACCTCAAGAAGATTTCACTCCAGAAGTGTACAGAGTTTTCCTCAACAACCTTTGCCCTCGACCTGAAATTGATAACATCTTTTCAGAATTTG GTGCAAAAAGCAAACCATATCTTACCGTTGATCAGATGATGGATTTTATCAACCTTAAGCAGCGAGATCCTCGGCTTAATGAAATACTTTATCCACCTCT AAAACAAGAGCAAGTCCAAGTATTGATTGAGAAGTATGAACCCAACAACAGCCTCGCCAGAAAAGGACAAATATCAGTGGATGGGTTCATGCGCTATCTG AGTGGAGAAGAAAACGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGACATGTCTCAGCCCCTTTCTCACTATTTCATTAATTCCTCGCACAACA CCTACCTCACAGCTGGCCAACTGGCTGGAAACTCCTCTGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGTGTGGAGCTGGACTGCTGGAA GGGACGGACTGCAGAAGAGGAACCTGTCATCACCCATGGCTTCACCATGACAACTGAAATATCTTTCAAGGAAGTGATAGAAGCAATTGCGGAGTGTGCA TTTAAGACTTCACCTTTTCCAATTCTCCTTTCGTTTGAGAACCATGTGGATTCCCCAAAGCAGCAAGCCAAGATGGCGGAGTACTGCCGACTGATCTTTG GGGATGCCCTTCTCATGGAGCCCCTGGAAAAATATCCACTGGAATCTGGAGTTCCTCTTCCAAGCCCTATGGATTTAATGTATAAAATTTTGGTGAAAAA TAAGAAGAAATCACACAAGTCATCAGAAGGAAGCGGCAAAAAGAAGCTCTCAGAACAAGCCTCCAACACCTACAGTGACTCCTCCAGCATGTTCGAGCCC TCATCCCCAGGAGCCGGAGAAGCTGATACGGAAAGTGACGACGACGATGATGATGATGACTGTAAAAAATCTTCAATGGATGAGGGGACTGCTGGAAGTG AGGCTATGGCCACAGAAGAAATGTCTAATCTGGTGAACTATATTCAGCCAGTCAAGTTTGAGTCATTTGAAATTTCAAAAAAAAGAAATAAAAGTTTTGA AATGTCTTCCTTCGTGGAAACCAAAGGACTTGAACAACTCACCAAGTCTCCAGTGGAATTTGTAGAATATAACAAAATGCAGCTTAGCAGGATATATCCA AAAGGAACACGTGTGGATTCATCCAACTATATGCCTCAGCTCTTCTGGAATGCAGGTTGTCAGATGGTGGCACTTAATTTCCAGACAATGGACCTGGCTA TGCAAATAAATATGGGGATGTATGAATACAACGGGAAGAGTGGCTACAGATTGAAGCCAGAGTTCATGAGGAGGCCTGACAAGCATTTTGATCCATTTAC TGAAGGCATCGTAGATGGGATAGTGGCAAACACTTTGTCTGTTAAGATTATTTCAGGTCAGTTTCTTTCTGATAAGAAAGTTGGGACTTACGTGGAAGTA GATATGTTTGGTTTGCCTGTGGATACAAGGAGGAAGGCATTTAAGACCAAAACATCCCAAGGAAATGCTGTGAATCCTGTCTGGGAAGAAGAACCTATTG TGTTCAAAAAGGTGGTTCTTCCTACTCTGGCCTGTTTGAGAATAGCAGTTTATGAAGAAGGAGGTAAATTCATTGGCCACCGTATCTTGCCAGTGCAAGC CATTCGGCCAGGCTATCACTATATCTGTCTAAGGAATGAAAGGAACCAGCCTCTGACGCTGCCTGCTGTCTTTGTCTACATAGAAGTGAAAGACTATGTG CCAGACACATATGCAGATGTCATCGAAGCTTTATCAAACCCAATCCGATATGTGAACCTGATGGAACAGAGAGCTAAGCAATTGGCTGCTTTGACACTGG AAGATGAAGAAGAAGTAAAGAAAGAGGCTGATCCTGGAGAAACACCATCAGAGGCTCCAAGTGAAGCGAGAACGACTCCAGCAGAAAATGGGGTGAATCA CACTACAACCCTGACACCCAAGCCACCCTCCCAGGCTCTCCACAGCCAGCCAGCTCCAGGTTCTGTAAAGGCACCTGCCAAAACAGAAGATCTTATTCAG AGTGTCTTAACAGAAGTGGAAGCACAGACCATCGAAGAACTAAAGCAACAGAAATCGTTTGTGAAACTTCAAAAGAAACACTACAAAGAAATGAAAGACC TGGTTAAGAGACACCACAAGAAAACCACTGACCTTATCAAAGAACACACTACCAAGTATAATGAAATTCAGAATGACTACTTGAGAAGGAGAGCCGCTTT GGAAAAGTCCGCCAAAAAGGACAGTAAGAAAAAATCGGAACCCAGCAGCCCTGATCATGGTTCATCAACGATTGAGCAAGACCTCGCTGCTCTGGATGCT GAAATGACCCAAAAGTTAATAGACTTGAAGGACAAACAACAGCAGCAGCTGCTTAATCTTCGGCAAGAACAGTATTATAGTGAAAAATACCAGAAGCGAG AACATATTAAACTGCTTATTCAAAAGTTGACGGATGTCGCAGAAGAGTGTCAGAACAATCAGTTAAAGAAGCTCAAAGAAATCTGTGAGAAAGAAAAGAA AGAATTAAAGAAGAAAATGGATAAAAAGAGGCAGGAGAAGATAACAGAAGCTAAATCCAAAGACAAAAGTCAGATGGAAGAGGAGAAGACAGAGATGATC CGGTCATATATCCAGGAAGTGGTGCAGTATATCAAGAGGCTAGAAGAAGCGCAAAGTAAACGGCAAGAAAAACTCGTAGAGAAACACAAGGAAATACGTC AGCAGATCCTGGATGAAAAGCCCAAGGGGGAAGGTTCCTCCTCATTCTTGTCGGAAACTTGCCATGAGGATCCCTCTGTTTCCCCCAACTTTACTCCCCC CAACCCTCAAGCTCTCAAGTGGTGACCACCGTCCTTCCGGCCAGCTGCAGGTGGAGCTGGAGCAAGAATACCAAGACAAATTCAAAAGACTGCCCCTCGA GATTTTGGAATTCGTGCAGGAAGCCATGAAAGGAAAGATCAGTGAAGACAGCAATCACGGTTCTGCCCCTCTCTCCCTGTCCTCAGACCCTGGAAAAGTG AACCACAAGACTCCCTCCAGTGAGGAGCTGGGAGGAGACATCCCAGGAAAAGAATTTGATACTCCTCTGTGAATGCTCCTGCCAGGCCTTCAGAAATTGC ATGGCCACTCCAGCGTCATCGGACTCTCTCTTATTACAAAGATCACTGCCCAGGACCATCTTCCCGAGAAGCATCCCTTAGCCTAAAATCCACACCAAAG GGAGAGTTCCAGAGGAATCCATGAAGAATTCCCATGCCCAGGCTCCATGTGTCATGTGGAAACCTCCACAGGTCTGCTAGTGAAGAATGCATGTATGTGA GATTTTTGTTTTCTTTCCAATAGCAAATTCAAAGCAAGCAACTTGCAGGCTCCATGGAACTTTTAATGAAGGACAGTGTCTTCTTTGAAGAAAATCAAGC TCGTGTTTTTATTCGAAGCTCTGGTGTAAAATATTTCAAAGTCATAGAAATAGTTTGAGAAATGCATAGCATTATTTAACACTATTGAACAGCCGACTTT GAGCATTGTTTCTTCTAACTGCCCCTCAACTACCATTATCTTCAAGTCAACATGCATATTACATTTTCATCCTTTGCTTTGCAAGCACTGGTGGCTTGCA GTTTGCTAATTTATTTATCATAGAGTCATCAATGTATTTGTTGCTGACATGGTTTTATTAGATACTGTAGTGATTCAAATAAGTTTTCTATTTGAAAAAA AAAATCACTTGATTGTATCCTTGCCCAGTGAAGCCATCCTAAGACTTAGCAATATGGATTGTACATTTGGCTGCATGAGCAAGTCGGCCGCACACTTCCA GACAGTGTGCTGTTTGAATTGACTATTTGCACTCAAAGTCTGGGTATTCATTGGTTATTGGCCTGAAATGATCAAATAACTACAAATGATCTGTTGAATA AAAATAGTTGAGCTGATATATGTTAAGCAGATATTCAATCAGAATGAACAGGTTCCGGTGGTTATTTTGCCGTTTGACATTTTTTATGGTTCATTTATTT TTAATATAGAGAGGAAGATTGAATATTTATCTAGAGAATACAAAGACCCACATGTAAATGATAGGTATTATCTCCATGTATATATGTACCCACTTAGTCA TGTAAGTGCATATACACATACACACACATGAGTGTAGACATGTGTTTATTAATTGACAATGACCCAAATCTCTTCCACAAGACTTAAAACCAAATTCAGG GACAAATGGATAGAGAAGAAAAGGGTCAAACATCGAGATTACATGGATGTTAAATTATATGGAGACGCTAAGAAATAATTGATGGAGCCATTGATGCAAA CCGAAGTAGATTTAGAACTTATATGAATTTGATTTATATTTTGCAAGATCAAAAATTAGATGTTAAGTATCAGATTTTAAGCTTGTTTTAATGGTCAAAA AATTAGGACAGAAATAATATGGACATTTATTAGTATCTTCCATAATTTTTAAGTCTGACACATTTCTATTTTATTCTAACATAAAAAAACTTCCATTATA TATTTACTAAGTATATTTAATTCACTTAACTCTGTCTTTATAAGTTCCTATTTTAGATGGAATAAGAGAAACAAATTATATCAAGGTAAAACTGATCAAA AGCATAATTGAAAGTTCTGAAAAAAGAAAAATAATAATATGTAGAAAAATGTAACTTAGAGAGTAACACATGAACATTGAAGTTAAAACCCAGAAGCCAG ATGCTCACAGTTTTATTTTACTTTAAAATAAACCTGTCTGACTGTAGCTTTGTGAAATATCTTAAAACGCAAAAACCAATTGTGTCCTGAAAATTGTTTC AAGAATTTAATATTTTTATGAAAATTATTTTATTTAACTTTAAGCAATAACTAGAGATTACAATTAAATTTTAATCAAAATGAAGGCTTAGTTCAAACAT AAGGAAACAGTGTTTGATTAAAAAAAACACATCTAGTAAGACGTAAGGGGAAAATCACATCCTCTTTGGAGATGATTATATTTTGATCTGAAGGGTTTGG GGTGTTCATTAGACACTTAATAAAACTTAACTTCCAATGAAAAAGAAATCTTTTGTAAATCATTCTACTTTTGCACTTTGAAAGAAAGGCGTTAATCATA AAGAAGCAAGAATGGTCAAAATCGAATGCTGCATTTTTATAAACAAAATTACAGACTGTCTGAAATTGAAGAAGAATGAACTAATAATAGCATTCATAAC CAAACACAATGATGATTATTGCAGAACATTGTATCACATTTTAGTCCAGAGATAGAATAAAGTTGAATAACCTTGACTTACACAAAACTGTTTTGGTAGT TGGATTTCATTATCTTAGTGAATTTAGTCATTTTACAATATGTTTGTATTTGGCCATTTACTGTAATCACATTTTTATATCTGTACAATGACACTTTTTG CAGTTGTGGGGTAGTGTGTAACACTGTCCATCTTGCATCATTGAAACTACTACAATGATACTATCATTTAATAATATTAATATTACTTGAAATAGACTAA GATAAAGAAAAGGGGTCTGTATGATGTGCAGTTTTGTGCCTTTATGTATTTGCCTTGTTCTTTGTCGAATGTGTGAAATTCCGTACTGTGGTTTTTCCTA TAATAGAAAGTAGAGCTGTGTATTAAATTAGACTGTGTCTCTCTGATACCTTTACACTACTGAGAATAGCATGGTTTTGGCCATGTAAACCAATTTTCAA AGTTCTAATGACATAGCCATGTGTTTTTGGTTTTTTATATTTCATTTTAAAATTTGAGTATCACCATACATTAATTAATACTCCTGTAGTAGATAAGCTG TCATTAAGTAATTCCCAAAAAAAGGGCCATTTGCTTGCATTACTTTGAATTTAATGTTGCGCTTGTGCACTGTGTTAATATTGTTTGTGATGGATTGGAC GTTGTGACTCTTGCCTTTTAAGAAGAAAAAAAAGATAGGACAAAGTATTTGAAGCTCTTAAAATGTACATATTTTGGTTCTTCTATCTCAAATTATTTAA AATGCATAATTCACATTTTTGTAATAATTCTATGCAATTTTGTGGCATGATGTTTCTTCCACTTGTAATTTTATGTGCTTTCATCACAAATCCAAAGGAA AGAATAAAAATTTCTTAACACAA

refseq_PLCB1.F1 (forward primer)
refseq_PLCB1.R1 (reverse primer)
Single exon skipping

Frame 0

QMAGAQPGVHALQLKPVCVSDSLKKGTKFVKWD DDSTIVTPIILRTDPQGFFFYWTDQNKETELLDL SLVKDARCGRHAKAPKDPKLRELLDVGNIGRLE QRMITVVYGPDLVNISHLNLVAFQEEVAKEWTN EVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPE GRIPLKNIYRLFSADRKRVETALEACSLPSSRN DSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEF GAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPL KQEQVQVLIEKYEPNNSLARKGQISVDGFMRYL SGEENGVVSPEKLDLNEDMSQPLSHYFINSSHN TYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWK GRTAEEEPVITHGFTMTTEISFKEVIEAIAECA FKTSPFPILLSFENHVDSPKQQAKMAEYCRLIF GDALLMEPLEKYPLESGVPLPSPMDLMYKILVKN KKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEP SSPGAGEADTESDDDDDDDDCKKSSMDEGTAGS EAMATEEMSNLVNYIQPVKFESFEISKKRNKSFE MSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYP KGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLA MQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFT EGIVDGIVANTLSVKIISGQFLSDKKVGTYVEV DMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPI VFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQA IRPGYHYICLRNERNQPLTLPAVFVYIEVKDYV PDTYADVIEALSNPIRYVNLMEQRAKQLAALTL EDEEEVKKEADPGETPSEAPSEARTTPAENGVNH TTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQ SVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKD LVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAAL EKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDA EMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKR EHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKK ELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMI RSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIR QQILDEKPKGEGSSSFLSETCHEDPSVSPNFTPP NPQALKW*PPSFRPAAGGAGARIPRQIQKTAPR DFGIRAGSHERKDQ*RQQSRFCPSLPVLRPWKS EPQDSLQ*GAGRRHPRKRI*YSSVNAPARPSEIA WPLQRHRTLSYYKDHCPGPSSREASLSLKSTPK GEFQRNP*RIPMPRLHVSCGNLHRSASEECMYV RFLFSFQ*QIQSKQLAGSMELLMKDSVFFEENQA RVFIRSSGVKYFKVIEIV*EMHSII*HY*TADF EHCFF*LPLNYHYLQVNMHITFSSFALQALVAC SLLIYLS*SHQCICC*HGFIRYCSDSNKFSI*KK KSLDCILAQ*SHPKT*QYGLYIWLHEQVGRTLP DSVLFELTICTQSLGIHWLLA*NDQITTNDLLN KNS*ADIC*ADIQSE*TGSGGYFAV*HFLWFIYF *YREED*IFI*RIQRPTCK**VLSPCIYVPT*S CKCIYTYTHMSVDMCLLIDNDPNLFHKT*NQIQ GQMDREEKGQTSRLHGC*IIWRR*EIIDGAIDAN RSRFRTYMNLIYILQDQKLDVKYQILSLF*WSK N*DRNNMDIY*YLP*FLSLTHFYFILT*KNFHY IFTKYI*FT*LCLYKFLF*ME*EKQIISR*N*SK A*LKVLKKEK**YVEKCNLESNT*TLKLKPRSQ MLTVLFYFKINLSDCSFVKYLKTQKPIVS*KLF QEFNIFMKIILFNFKQ*LEITIKF*SK*RLSSNI RKQCLIKKNTSSKT*GENHILFGDDYILI*RVW GVH*TLNKT*LPMKKKSFVNHSTFAL*KKGVNH KEARMVKIECCIFINKITDCLKLKKNELIIAFIT KHNDDYCRTLYHILVQR*NKVE*P*LTQNCFGS WISLS**I*SFYNMFVFGHLL*SHFYICTMTLF AVVG*CVTLSILHH*NYYNDTII**Y*YYLK*TK IKKRGLYDVQFCAFMYLPCSLSNV*NSVLWFFL **KVELCIKLDCVSLIPLHY*E*HGFGHVNQFS KF**HSHVFLVFYISF*NLSITIH*LILL**ISC H*VIPKKRAICLHYFEFNVALVHCVNIVCDGLD VVTLAF*EEKKDRTKYLKLLKCTYFGSSISNYL KCIIHIFVIILCNFVA*CFFHL*FYVLSSQIQRK E*KFLNT

Frame 1

RWPGLNPECTPCNSSPCACPTASRRAPNSSSGM MTQLLLLQLF*GLTLRDFSFTGQIKTRRQSYWI SALSKMPDVGDTPKLPRTPNYVNFWMWGTSGAWS SA*SQWCMGLTS*TSPI*ISWLSKKKWPRNGQM RFSVWQQTCWPKTCPGMHFWKKPILNLSCKSLQ KGVFLSKTYIACFQQIGSELKLL*RLVVFHLQGM IQYLKKISLQKCTEFSSTTFALDLKLITSFQNL VQKANHILPLIR*WILSTLSSEILGLMKYFIHL *NKSKSKY*LRSMNPTTASPEKDKYQWMGSCAI* VEKKTESFHLRNWI*MKTCLSPFLTISLIPRTT PTSQLANWLETPLLRCIAKCSCLVVAVWSWTAG RDGLQKRNLSSPMASP*QLKYLSRK**KQLRSVH LRLHLFQFSFRLRTMWIPQSSKPRWRSTAD*SL GMPFSWSPWKNIHWNLEFLFQALWI*CIKFW*K IRRNHTSHQKEAAKRSSQNKPPTPTVTPPACSSP HPQEPEKLIRKVTTTMMMMTVKNLQWMRGLLEV RLWPQKKCLIW*TIFSQSSLSHLKFQKKEIKVL KCLPSWKPKDLNNSPSLQWNL*NITKCSLAGYIQ KEHVWIHPTICLSSSGMQVVRWWHLISRQWTWL CK*IWGCMNTTGRVATD*SQSS*GGLTSILIHL LKAS*MG*WQTLCLLRLFQVSFFLIRKLGLTWK* ICLVCLWIQGGRHLRPKHPKEML*ILSGKKNLL CSKRWFFLLWPV*E*QFMKKEVNSLATVSCQCK PFGQAITISV*GMKGTSL*RCLLSLST*K*KTMC QTHMQMSSKLYQTQSDM*T*WNRELSNWLL*HW KMKKK*RKRLILEKHHQRLQVKRERLQQKMG*I TLQP*HPSHPPRLSTASQLQVL*RHLPKQKILFR VS*QKWKHRPSKN*SNRNRL*NFKRNTTKK*KT WLRDTTRKPLTLSKNTLPSIMKFRMTT*EGEPL WKSPPKRTVRKNRNPAALIMVHQRLSKTSLLWML K*PKS**T*RTNNSSSCLIFGKNSIIVKNTRSE NILNCLFKS*RMSQKSVRTIS*RSSKKSVRKKR KN*RRKWIKRGRRR*QKLNPKTKVRWKRRRQR*S GHISRKWCSISRG*KKRKVNGKKNS*RNTRKYV SRSWMKSPRGKVPPHSCRKLAMRIPLFPPTLLP PTLKLSSGDHRPSGQLQVELEQEYQDKFKRLPLE ILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKV NHKTPSSEELGGDIPGKEFDTPL*MLLPGLQKL HGHSSVIGLSLITKITAQDHLPEKHPLA*NPHQR ESSRGIHEEFPCPGSMCHVETSTGLLVKNACM* DFCFLSNSKFKASNLQAPWNF**RTVSSLKKIK LVFLFEALV*NISKS*K*FEKCIALFNTIEQPTL SIVSSNCPSTTIIFKSTCILHFHPLLCKHWWLA VC*FIYHRVINVFVADMVLLDTVVIQISFLFEK KNHLIVSLPSEAILRLSNMDCTFGCMSKSAAHFQ TVCCLN*LFALKVWVFIGYWPEMIK*LQMIC*I KIVELIYVKQIFNQNEQVPVVILPFDIFYGSFI FNIERKIEYLSREYKDPHVNDRYYLHVYMYPLSH VSAYTHTHT*V*TCVY*LTMTQISSTRLKTKFR DKWIEKKRVKHRDYMDVKLYGDAKK*LMEPLMQ TEVDLELI*I*FIFCKIKN*MLSIRF*ACFNGQK IRTEIIWTFISIFHNF*V*HISILF*HKKTSII YLLSIFNSLNSVFISSYFRWNKRNKLYQGKTDQ KHN*KF*KKKNNNM*KNVT*RVTHEH*S*NPEAR CSQFYFTLK*TCLTVAL*NILKRKNQLCPENCF KNLIFL*KLFYLTLSNN*RLQLNFNQNEGLVQT *GNSV*LKKTHLVRRKGKITSSLEMIIF*SEGFG VFIRHLIKLNFQ*KRNLL*IILLLHFERKALII KKQEWSKSNAAFL*TKLQTV*N*RRMN***HS* PNTMMIIAEHCITF*SRDRIKLNNLDLHKTVLVV GFHYLSEFSHFTICLYLAIYCNHIFISVQ*HFL QLWGSV*HCPSCIIETTTMILSFNNINIT*NRL R*RKGVCMMCSFVPLCICLVLCRMCEIPYCGFSY NRK*SCVLN*TVSL*YLYTTENSMVLAM*TNFQ SSNDIAMCFWFFIFHFKI*VSPYIN*YSCSR*A VIK*FPKKGPFACITLNLMLRLCTVLILFVMDWT L*LLPFKKKKKIGQSI*SS*NVHILVLLSQII* NA*FTFL**FYAILWHDVSSTCNFMCFHHKSKG KNKNFLTQ

Frame 2

DGRGSTRSARLATQARVRVRQPQEGHQIRQVG* *LNYCYSNYFED*PSGIFLLLDRSKQGDRATGS QPCQRCQMWETRQSSQGPQIT*TFGCGEHRAPG AAHDHSGVWA*PREHLPFESRGFPRRSGQGMDK* GFQFGNKPAGPKHVQGCISGKSLY*T*AASHSR RAYSSQKHISLVFSRSEAS*NCFRGL*SSIFKE *FNTSRRFHSRSVQSFPQQPLPST*N**HLFRIW CKKQTISYR*SDDGFYQP*AARSSA**NTLSTS KTRASPSID*EV*TQQQPRQKRTNISGWVHALS EWRRKRSRFT*ETGFE*RHVSAPFSLFH*FLAQH LPHSWPTGWKLLC*DVSPSAPVWLSLCGAGLLE GTDCRRGTCHHPWLHHDN*NIFQGSDRSNCGVC I*DFTFSNSPFV*EPCGFPKAASQDGGVLPTDLW GCPSHGAPGKISTGIWSSSSKPYGFNV*NFGEK *EEITQVIRRKRQKEALRTSLQHLQ*LLQHVRA LIPRSRRS*YGK*RRR****L*KIFNG*GDCWK* GYGHRRNV*SGELYSASQV*VI*NFKKKK*KF* NVFLRGNQRT*TTHQVSSGICRI*QNAA*QDIS KRNTCGFIQLYASALLECRLSDGGT*FPDNGPGY ANKYGDV*IQREEWLQIEARVHEEA*QAF*SIY *RHRRWDSGKHFVC*DYFRSVSF**ESWDLRGS RYVWFACGYKEEGI*DQNIPRKCCESCLGRRTYC VQKGGSSYSGLFENSSL*RRR*IHWPPYLASAS HSARLSLYLSKE*KEPASDAACCLCLHRSERLC ARHICRCHRSFIKPNPICEPDGTES*AIGCFDTG R*RRSKERG*SWRNTIRGSK*SENDSSRKWGES HYNPDTQATLPGSPQPASSRFCKGTCQNRRSYS ECLNRSGSTDHRRTKATEIVCETSKETLQRNERP G*ETPQENH*PYQRTHYQV**NSE*LLEKESRF GKVRQKGQ*EKIGTQQP*SWFIND*ARPRCSGC *NDPKVNRLEGQTTAAAA*SSARTVL**KIPEAR TY*TAYSKVDGCRRRVSEQSVKEAQRNL*ERKE RIKEENG*KEAGEDNRS*IQRQKSDGRGEDRDD PVIYPGSGAVYQEARRSAK*TARKTRRETQGNTS ADPG*KAQGGRFLLILVGNLP*GSLCFPQLYSP QPSSSQVVTTVLPASCRWSWSKNTKTNSKDCPS RFWNSCRKP*KERSVKTAITVLPLSPCPQTLEK* TTRLPPVRSWEETSQEKNLILLCECSCQAFRNC MATPASSDSLLLQRSLPRTIFPRSIP*PKIHTK GRVPEESMKNSHAQAPCVMWKPPQVC**RMHVCE IFVFFPIANSKQATCRLHGTFNEGQCLL*RKSS SCFYSKLWCKIFQSHRNSLRNA*HYLTLLNSRL *ALFLLTAPQLPLSSSQHAYYIFILCFASTGGLQ FANLFIIESSMYLLLTWFY*IL**FK*VFYLKK KIT*LYPCPVKPS*DLAIWIVHLAA*ASRPHTS RQCAV*IDYLHSKSGYSLVIGLK*SNNYK*SVE* K*LS*YMLSRYSIRMNRFRWLFCRLTFFMVHLF LI*RGRLNIYLENTKTHM*MIGIISMYICTHLV M*VHIHIHTHECRHVFIN*Q*PKSLPQDLKPNSG TNG*RRKGSNIEITWMLNYMETLRNN*WSH*CK PK*I*NLYEFDLYFARSKIRC*VSDFKLVLMVK KLGQK*YGHLLVSSIIFKSDTFLFYSNIKKLPLY IY*VYLIHLTLSL*VPILDGIRETNYIKVKLIK SIIESSEKRKIIICRKM*LRE*HMNIEVKTQKP DAHSFILL*NKPV*L*LCEIS*NAKTNCVLKIVS RI*YFYENYFI*L*AITRDYN*ILIKMKA*FKH KETVFD*KKHI**DVRGKSHPLWR*LYFDLKGL GCSLDT**NLTSNEKEIFCKSFYFCTLKERR*S* RSKNGQNRMLHFYKQNYRLSEIEEE*TNNSIHN QTQ**LLQNIVSHFSPEIE*S*ITLTYTKLFW* LDFIILVNLVILQYVCIWPFTVITFLYLYNDTFC SCGVVCNTVHLASLKLLQ*YYHLIILILLEID* DKEKGSV*CAVLCLYVFALFFVECVKFRTVVFP IIESRAVY*IRLCLSDTFTLLRIAWFWPCKPIFK VLMT*PCVFGFLYFILKFEYHHTLINTPVVDKL SLSNSQKKGHLLALL*I*CCACALC*YCL*WIG RCDSCLLRRKKR*DKVFEALKMYIFWFFYLKLFK MHNSHFCNNSMQFCGMMFLPLVILCAFITNPKE RIKIS*H