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Sequences

Sequence NM_130440

CGGGAGCGGCGGGAGCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTCCGGCTCCAGC TCGGGTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCGGGGGGACATGCGGACCGACG GCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGACCGGGGTGAAGAAGCAAAGACTCGGTTGA TTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGTGCCTGCACTGGTGATG CTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGT GCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGC AGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCC AAGCTCTCAGTGCTCGAAGAGGAACAGCTGCCCCCTGGGTTCCCTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCA TGCTATGTGCCGCAGGCGGAAATCCAGACCCTGAGATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCT GCGTTCAGGTGCCTTGCAGATAGAGAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTACTCAGCCCCT GCGAACCTGTATGTGCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCG TGGCAGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCTGGAGCT CAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGTGAAAGCTCTTCCAAAG CCTCCGATTGATCTTGTGGTGACAGAGACAACTGCCACCAGTGTCACCCTCACCTGGGACTCTGGGAACTCGGAGCCTGTAACCTACTATGGCATCCAGT ACCGCGCAGCGGGCACGGAGGGCCCCTTTCAGGAGGTGGATGGTGTGGCCACCACCCGCTACAGCATTGGCGGCCTCAGCCCTTTCTCGGAATATGCCTT CCGCGTGCTGGCGGTGAACAGCATCGGGCGAGGGCCGCCCAGCGAGGCAGTGCGGGCACGCACGGGAGAACAGGCGCCCTCCAGCCCACCGCGCCGCGTG CAGGCACGCATGCTGAGCGCCAGCACCATGCTGGTGCAGTGGGAGCCTCCCGAGGAGCCCAACGGCCTGGTGCGGGGATACCGCGTCTACTATACTCCGG ACTCCCGCCGCCCCCCGAACGCCTGGCACAAGCACAACACCGACGCGGGGCTCCTCACGACCGTGGGCAGCCTGCTGCCTGGCATCACCTACAGCCTGCG CGTGCTTGCCTTCACCGCCGTGGGCGATGGCCCTCCCAGCCCCACCATCCAGGTCAAGACGCAGCAGGGAGTGCCTGCCCAGCCCGCGGACTTCCAGGCC GAGGTGGAGTCGGACACCAGGATCCAGCTCTCGTGGCTGCTGCCCCCTCAGGAGCGGATCATCATGTATGAACTGGTGTACTGGGCGGCAGAGGACGAAG ACCAACAGCACAAGGTGACCTTCGACCCAACCTCCTCCTACACACTAGAGGACCTGAAGCCTGACACACTCTACCGCTTCCAGCTGGCTGCACGCTCGGA TATGGGGGTGGGCGTCTTCACCCCCACCATTGAGGCCCGCACAGCCCAGTCCACCCCCTCCGCCCCTCCCCAGAAGGTGATGTGTGTGAGCATGGGCTCC ACCACGGTCCGGGTAAGTTGGGTCCCGCCGCCTGCCGACAGCCGCAACGGCGTTATCACCCAGTACTCCGTGGCCTACGAGGCGGTGGACGGCGAGGACC GCGGGCGGCATGTGGTGGATGGCATCAGCCGTGAGCACTCCAGCTGGGACCTGGTGGGCCTGGAGAAGTGGACGGAGTACCGGGTGTGGGTGCGGGCACA CACAGACGTGGGCCCCGGCCCCGAGAGCAGCCCGGTGCTGGTGCGCACCGATGAGGACGTGCCCAGCGGGCCTCCGCGGAAGGTGGAGGTGGAGCCACTG AACTCCACTGCTGTGCATGTCTACTGGAAGCTGCCTGTCCCCAGCAAGCAGCATGGCCAGATCCGCGGCTACCAGGTCACCTACGTGCGGCTGGAGAATG GCGAGCCCCGTGGACTCCCCATCATCCAAGACGTCATGCTAGCCGAGGCCCAGGAAACCACTATCAGCGGCCTGACCCCGGAGACCACCTACTCCGTTAC TGTTGCTGCCTATACCACCAAGGGGGATGGTGCCCGCAGCAAGCCCAAAATTGTCACTACAACAGGTGCAGTCCCAGGCCGGCCCACCATGATGATCAGC ACCACGGCCATGAACACTGCGCTGCTCCAGTGGCACCCACCCAAGGAACTGCCTGGCGAGCTGCTGGGCTACCGGCTGCAGTACTGCCGGGCCGACGAGG CGCGGCCCAACACCATAGATTTCGGCAAGGATGACCAGCACTTCACAGTCACCGGCCTGCACAAGGGGACCACCTACATCTTCCGGCTTGCTGCCAAGAA CCGGGCTGGCTTGGGTGAGGAGTTCGAGAAGGAGATCAGGACCCCCGAGGACCTGCCCAGCGGCTTCCCCCAAAACCTGCATGTGACAGGACTGACCACG TCTACCACAGAACTGGCCTGGGACCCGCCAGTGCTGGCGGAGAGGAACGGGCGCATCATCAGCTACACCGTGGTGTTCCGAGACATCAACAGCCAACAGG AGCTGCAGAACATCACGACAGACACCCGCTTTACCCTTACTGGCCTCAAGCCAGACACCACTTACGACATCAAGGTCCGCGCATGGACCAGCAAAGGCTC TGGCCCACTCAGCCCCAGCATCCAGTCCCGGACCATGCCGGTGGAGCAAGTGTTTGCCAAGAACTTCCGGGTGGCGGCTGCAATGAAGACGTCTGTGCTG CTCAGCTGGGAGGTTCCCGACTCCTATAAGTCAGCTGTGCCCTTTAAGATTCTGTACAATGGGCAGAGTGTGGAGGTGGACGGGCACTCGATGCGGAAGC TGATCGCAGACCTGCAGCCCAACACAGAGTACTCGTTTGTGCTGATGAACCGTGGCAGCAGCGCAGGGGGCCTGCAGCACCTGGTGTCCATCCGCACAGC CCCCGACCTCCTGCCTCACAAGCCGCTGCCTGCCTCTGCCTACATAGAGGACGGCCGCTTCGATCTCTCCATGCCCCATGTGCAAGACCCCTCGCTTGTC AGGTGGTTCTACATTGTTGTGGTGCCCATTGACCGTGTGGGCGGGAGCATGCTGACGCCAAGGTGGAGCACACCCGAGGAACTGGAGCTGGACGAGCTTC TAGAAGCCATCGAGCAAGGCGGAGAGGAGCAGCGGCGGCGGCGGCGGCAGGCAGAACGTCTGAAGCCATATGTGGCTGCTCAACTGGATGTGCTCCCGGA GACCTTTACCTTGGGGGACAAGAAGAACTACCGGGGCTTCTACAACCGGCCCCTGTCTCCGGACTTGAGCTACCAGTGCTTTGTGCTTGCCTCCTTGAAG GAACCCATGGACCAGAAGCGCTATGCCTCCAGCCCCTACTCGGATGAGATCGTGGTCCAGGTGACACCAGCCCAGCAGCAGGAGGAGCCGGAGATGCTGT GGGTGACGGGTCCCGTGCTGGCAGTCATCCTCATCATCCTCATTGTCATCGCCATCCTCTTGTTCAAAAGGAAAAGGACCCACTCTCCGTCCTCTAAGGA TGAGCAGTCGATCGGACTGAAGGACTCCTTGCTGGCCCACTCCTCTGACCCTGTGGAGATGCGGAGGCTCAACTACCAGACCCCAGGTATGCGAGACCAC CCACCCATCCCCATCACCGACCTGGCGGACAACATCGAGCGCCTCAAAGCCAACGATGGCCTCAAGTTCTCCCAGGAGTATGAGTCCATCGACCCTGGAC AGCAGTTCACGTGGGAGAATTCAAACCTGGAGGTGAACAAGCCCAAGAACCGCTATGCGAATGTCATCGCCTACGACCACTCTCGAGTCATCCTTACCTC TATCGATGGCGTCCCCGGGAGTGACTACATCAATGCCAACTACATCGATGGCTACCGCAAGCAGAATGCCTACATCGCCACGCAGGGCCCCCTGCCCGAG ACCATGGGTGATTTCTGGAGGATGGTGTGGGAACAGCGCACGGCCACTGTGGTCATGATGACACGGCTGGAGGAGAAGTCCCGGGTAAAATGTGATCAGT ACTGGCCAGCCCGTGGCACCGAGACCTGTGGCCTTATTCAGGTGACCCTGTTGGACACAGTGGAGCTGGCCACATACACTGTGCGCACCTTCGCACTCCA CAAGAGTGGCTCCAGTGAGAAGCGCGAGCTGCGTCAGTTTCAGTTCATGGCCTGGCCAGACCATGGAGTTCCTGAGTACCCAACTCCCATCCTGGCCTTC CTACGACGGGTCAAGGCCTGCAACCCCCTAGACGCAGGGCCCATGGTGGTGCACTGCAGCGCGGGCGTGGGCCGCACCGGCTGCTTCATCGTGATTGATG CCATGTTGGAGCGGATGAAGCACGAGAAGACGGTGGACATCTATGGCCACGTGACCTGCATGCGATCACAGAGGAACTACATGGTGCAGACGGAGGACCA GTACGTGTTCATCCATGAGGCGCTGCTGGAGGCTGCCACGTGCGGCCACACAGAGGTGCCTGCCCGCAACCTGTATGCCCACATCCAGAAGCTGGGCCAA GTGCCTCCAGGGGAGAGTGTGACCGCCATGGAGCTCGAGTTCAAGTTGCTGGCCAGCTCCAAGGCCCACACGTCCCGCTTCATCAGCGCCAACCTGCCCT GCAACAAGTTCAAGAACCGGCTGGTGAACATCATGCCCTACGAATTGACCCGTGTGTGTCTGCAGCCCATCCGTGGTGTGGAGGGCTCTGACTACATCAA TGCCAGCTTCCTGGATGGTTATAGACAGCAGAAGGCCTACATAGCTACACAGGGGCCTCTGGCAGAGAGCACCGAGGACTTCTGGCGCATGCTATGGGAG CACAATTCCACCATCATCGTCATGCTGACCAAGCTTCGGGAGATGGGCAGGGAGAAATGCCACCAGTACTGGCCAGCAGAGCGCTCTGCTCGCTACCAGT ACTTTGTTGTTGACCCGATGGCTGAGTACAACATGCCCCAGTATATCCTGCGTGAGTTCAAGGTCACGGATGCCCGGGATGGGCAGTCAAGGACAATCCG GCAGTTCCAGTTCACAGACTGGCCAGAGCAGGGCGTGCCCAAGACAGGCGAGGGATTCATTGACTTCATCGGGCAGGTGCATAAGACCAAGGAGCAGTTT GGACAGGATGGGCCTATCACGGTGCACTGCAGTGCTGGCGTGGGCCGCACCGGGGTGTTCATCACTCTGAGCATCGTCCTGGAGCGCATGCGCTACGAGG GCGTGGTCGACATGTTTCAGACCGTGAAGACCCTGCGTACACAGCGTCCTGCCATGGTGCAGACAGAGGACCAGTATCAGCTGTGCTACCGTGCGGCCCT GGAGTACCTCGGCAGCTTTGACCACTATGCAACGTAACTACCGCTCCCCTCTCCTCCGCCACCCCCGCCGTGGGGCTCCGGAGGGGACCCAGCTCCTCTG AGCCATACCGACCATCGTCCAGCCCTCCTACGCAGATGCTGTCACTGGCAGAGCACAGCCCACGGGGATCACAGCGTTTCAGGAACGTTGCCACACCAAT CAGAGAGCCTAGAACATCCCTGGGCAAGTGGATGGCCCAGCAGGCAGGCACTGTGGCCCTTCTGTCCACCAGACCCACCTGGAGCCCGCTTCAAGCTCTC TGTTGCGCTCCCGCATTTCTCATGCTTCTTCTCATGGGGTGGGGTTGGGGCAAAGCCTCCTTTTTAATACATTAAGTGGGGTAGACTGAGGGATTTTAGC CTCTTCCCTCTGATTTTTCCTTTCGCGAATCCGTATCTGCAGAATGGGCCACTGTAGGGGTTGGGGTTTATTTTGTTTTGTTTTTTTTTTTTGACTTCTG CTGAAGGACAGAACATTGCCTTCCTCGTGCAGAGCTGGGGCTGCCAGCCTGAGCGGAGGCTCGGCCGTGGGCCGGGAGGCAGTGCTGATCCGGCTGCTCC TCCAGCCCTTCAGACGAGATCCTGTTTCAGCTAAATGCAGGGAAACTCAATGTTTTTTTAAGTTTTGTTTTCCCTTTAAAGCCTTTTTTTAGGCCACATT GACAGTGGTGGGCGGGGAGAAGATAGGGAACACTCATCCCTGGTCGTCTATCCCAGTGTGTGTTTAACATTCACAGCCCAGAACCACAGATGTGTCTGGG AGAGCCTGGCAAGGCATTCCTCATCACCATCGTGTTTGCAAAGGTTAAAACAAAAACAAAAAACCACAAAAATAAAAAACAAAAAAAACAAAAAACCCAA GAAAAAAAAAAAGAGTCAGCCCTTGGCTTCTGCTTCAAACCCTCAAGAGGGGAAGCAACTCCGTGTGCCTGGGGTTCCCGAGGGAGCTGCTGGCTGACCT GGGCCCACAGAGCCTGGCTTTGGTCCCCAGCATTGCAGTATGGTGTGGTGTTTGTAGGCTGTGGGGTCTGGCTGTGTGGCCAAGGTGAATAGCACAGGTT AGGGTGTGTGCCACACCCCATGCACCTCAGGGCCAAGCGGGGGCGTGGCTGGCCTTTCAGGTCCAGGCCAGTGGGCCTGGTAGCACATGTCTGTCCTCAG AGCAGGGGCCAGATGATTTTCCTCCCTGGTTTGCAGCTGTTTTCAAAGCCCCCGATAATCGCTCTTTTCCACTCCAAGATGCCCTCATAAACCAATGTGG CAAGACTACTGGACTTCTATCAATGGTACTCTAATCAGTCCTTATTATCCCAGCTTGCTGAGGGGCAGGGAGAGCGCCTCTTCCTCTGGGCAGCGCTATC TAGATAGGTAAGTGGGGGCGGGGAAGGGTGCATAGCTGTTTTAGCTGAGGGACGTGGTGCCGACGTCCCCAAACCTAGCTAGGCTAAGTCAAGATCAACA TTCCAGGGTTGGTAATGTTGGATGATGAAACATTCATTTTTACCTTGTGGATGCTAGTGCTGTAGAGTTCACTGTTGTACACAGTCTGTTTTCTATTTGT TAAGAAAAACTACAGCATCATTGCATAATTCTTGATGGTAATAAATTTGAATAATCAGATTTCTTACAAA

refseq_PTPRF.F1 (forward primer)
refseq_PTPRF.R1 (reverse primer)
Single exon skipping

Frame 0

RERRERWRRQRRRLQLRLRLGLGLRLRLRLRLQ LGWRWRERDQVEAAAAEEWEQRP*RLAGGHADRR PLDRRKEWRPWCPALGAEYPARVTGVKKQRLG* LSWAVAGCGARALDGP*ASPREDDGAPCACTGD AWFGGRRPW*QQTCLH*SP*GPDWAVRRGSLLRV PSYRRTQAAHHMDEEGEESQLPALRGH*V**WG RVSASDPAIAGAAR*SHL*VYSY*QPG*DQH*C QALSARRGTAAPWVPFHRHGASAEGGGEGTHSHH AMCRRRKSRP*DFLVQGLPSCRPCHEQRPHQAA AFRCLADREQ*GIRPRQVRVCGDQLGRHTLLSP CEPVCASAPRGSSFLHPSQQPGGDARRQREPDMR GSGCTHALREVDDGGRGAHQGG*DASWPQRPGA QQCRTLCQLHLCGHLLAGHDRGHSPGHSESSSK ASD*SCGDRDNCHQCHPHLGLWELGACNLLWHPV PRSGHGGPLSGGGWCGHHPLQHWRPQPFLGICL PRAGGEQHRARAAQRGSAGTHGRTGALQPTAPR AGTHAERQHHAGAVGASRGAQRPGAGIPRLLYSG LPPPPERLAQAQHRRGAPHDRGQPAAWHHLQPA RACLHRRGRWPSQPHHPGQDAAGSACPARGLPG RGGVGHQDPALVAAAPSGADHHV*TGVLGGRGRR PTAQGDLRPNLLLHTRGPEA*HTLPLPAGCTLG YGGGRLHPHH*GPHSPVHPLRPSPEGDVCEHGL HHGPGKLGPAACRQPQRRYHPVLRGLRGGGRRGP RAACGGWHQP*ALQLGPGGPGEVDGVPGVGAGT HRRGPRPREQPGAGAHR*GRAQRASAEGGGGAT ELHCCACLLEAACPQQAAWPDPRLPGHLRAAGEW RAPWTPHHPRRHASRGPGNHYQRPDPGDHLLRY CCCLYHQGGWCPQQAQNCHYNRCSPRPAHHDDQ HHGHEHCAAPVAPTQGTAWRAAGLPAAVLPGRRG AAQHHRFRQG*PALHSHRPAQGDHLHLPACCQE PGWLG*GVREGDQDPRGPAQRLPPKPACDRTDH VYHRTGLGPASAGGEERAHHQLHRGVPRHQQPTG AAEHHDRHPLYPYWPQARHHLRHQGPRMDQQRL WPTQPQHPVPDHAGGASVCQELPGGGCNEDVCA AQLGGSRLL*VSCAL*DSVQWAECGGGRALDAEA DRRPAAQHRVLVCADEPWQQRRGPAAPGVHPHS PRPPASQAAACLCLHRGRPLRSLHAPCARPLAC QVVLHCCGAH*PCGREHADAKVEHTRGTGAGRAS RSHRARRRGAAAAAAAGRTSEAICGCSTGCAPG DLYLGGQEELPGLLQPAPVSGLELPVLCACLLE GTHGPEALCLQPLLG*DRGPGDTSPAAGGAGDAV GDGSRAGSHPHHPHCHRHPLVQKEKDPLSVL*G *AVDRTEGLLAGPLL*PCGDAEAQLPDPRYARP PTHPHHRPGGQHRAPQSQRWPQVLPGV*VHRPWT AVHVGEFKPGGEQAQEPLCECHRLRPLSSHPYL YRWRPRE*LHQCQLHRWLPQAECLHRHAGPPAR DHG*FLEDGVGTAHGHCGHDDTAGGEVPGKM*SV LASPWHRDLWPYSGDPVGHSGAGHIHCAHLRTP QEWLQ*EARAASVSVHGLARPWSS*VPNSHPGL PTTGQGLQPPRRRAHGGALQRGRGPHRLLHRD*C HVGADEAREDGGHLWPRDLHAITEELHGADGGP VRVHP*GAAGGCHVRPHRGACPQPVCPHPEAGP SASRGECDRHGARVQVAGQLQGPHVPLHQRQPAL QQVQEPAGEHHALRIDPCVSAAHPWCGGL*LHQ CQLPGWL*TAEGLHSYTGASGREHRGLLAHAMG AQFHHHRHADQASGDGQGEMPPVLASRALCSLPV LCC*PDG*VQHAPVYPA*VQGHGCPGWAVKDNP AVPVHRLARAGRAQDRRGIH*LHRAGA*DQGAV WTGWAYHGALQCWRGPHRGVHHSEHRPGAHALRG RGRHVSDREDPAYTASCHGADRGPVSAVLPCGP GVPRQL*PLCNVTTAPLSSATPAVGLRRGPSSS EPYRPSSSPPTQMLSLAEHSPRGSQRFRNVATPI REPRTSLGKWMAQQAGTVALLSTRPTWSPLQAL CCAPAFLMLLLMGWGWGKASFLIH*VG*TEGF* PLPSDFSFRESVSAEWATVGVGVYFVLFFFFDFC *RTEHCLPRAELGLPA*AEARPWAGRQC*SGCS SSPSDEILFQLNAGKLNVFLSFVFPLKPFFRPH *QWWAGRR*GTLIPGRLSQCVFNIHSPEPQMCLG EPGKAFLITIVFAKVKTKTKNHKNKKQKKQKTQ EKKKESALGFCFKPSRGEATPCAWGSRGSCWLT WAHRAWLWSPALQYGVVFVGCGVWLCGQGE*HRL GCVPHPMHLRAKRGRGWPFRSRPVGLVAHVCPQ SRGQMIFLPGLQLFSKPPIIALFHSKMPS*TNV ARLLDFYQWYSNQSLLSQLAEGQGERLFLWAALS R*VSGGGEGCIAVLAEGRGADVPKPS*AKSRST FQGW*CWMMKHSFLPCGC*CCRVHCCTQSVFYL LRKTTASLHNS*W**I*IIRFLT

Frame 1

GSGGSGGGGRGGGSSFGSGSGSGSGSGSGSGSS SGGGGGSGTRWRRRRQRSGSSGPSGLRGDMRTD GPWIGGRSGGPGARPLVLSIQQE*PG*RSKDSVD CPGLWLAVELEPWMAPEPAPGRTMVPLVPALVM LGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFV CQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGA GSVLRIQPLRVQRDEAIYECTATNSLGEINTSA KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTAT MLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQL RSGALQIESSEESDQGKYECVATNSAGTRYSAP ANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTC VAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLEL SNVVRSANYTCVAISSLGMIEATAQVTVKALPK PPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQ YRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAF RVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTP DSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLR VLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQA EVESDTRIQLSWLLPPQERIIMYELVYWAAEDE DQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSD MGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS TTVRVSWVPPPADSRNGVITQYSVAYEAVDGED RGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAH TDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN GEPRGLPIIQDVMLAEAQETTISGLTPETTYSVT VAAYTTKGDGARSKPKIVTTTGAVPGRPTMMIS TTAMNTALLQWHPPKELPGELLGYRLQYCRADE ARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKN RAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTT STTELAWDPPVLAERNGRIISYTVVFRDINSQQ ELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGS GPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVL LSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRK LIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTA PDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLV RWFYIVVVPIDRVGGSMLTPRWSTPEELELDEL LEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPE TFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLK EPMDQKRYASSPYSDEIVVQVTPAQQQEEPEML WVTGPVLAVILIILIVIAILLFKRKRTHSPSSKD EQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDH PPIPITDLADNIERLKANDGLKFSQEYESIDPG QQFTWENSNLEVNKPKNRYANVIAYDHSRVILTS IDGVPGSDYINANYIDGYRKQNAYIATQGPLPE TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ YWPARGTETCGLIQVTLLDTVELATYTVRTFALH KSGSSEKRELRQFQFMAWPDHGVPEYPTPILAF LRRVKACNPLDAGPMVVHCSAGVGRTGCFIVID AMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQ YVFIHEALLEAATCGHTEVPARNLYAHIQKLGQ VPPGESVTAMELEFKLLASSKAHTSRFISANLP CNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYIN ASFLDGYRQQKAYIATQGPLAESTEDFWRMLWE HNSTIIVMLTKLREMGREKCHQYWPAERSARYQ YFVVDPMAEYNMPQYILREFKVTDARDGQSRTIR QFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQF GQDGPITVHCSAGVGRTGVFITLSIVLERMRYE GVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL EYLGSFDHYAT*LPLPSPPPPPPWGSGGDPAPL SHTDHRPALLRRCCHWQSTAHGDHSVSGTLPHQ SESLEHPWASGWPSRQALWPFCPPDPPGARFKLS VALPHFSCFFSWGGVGAKPPF*YIKWGRLRDFS LFPLIFPFANPYLQNGPL*GLGFILFCFFFLTS AEGQNIAFLVQSWGCQPERRLGRGPGGSADPAAP PALQTRSCFS*MQGNSMFF*VLFSL*SLFLGHI DSGGRGEDREHSSLVVYPSVCLTFTAQNHRCVW ESLARHSSSPSCLQRLKQKQKTTKIKNKKNKKPK KKKKSQPLASASNPQEGKQLRVPGVPEGAAG*P GPTEPGFGPQHCSMVWCL*AVGSGCVAKVNSTG *GVCHTPCTSGPSGGVAGLSGPGQWAW*HMSVLR AGAR*FSSLVCSCFQSPR*SLFSTPRCPHKPMW QDYWTSINGTLISPYYPSLLRGRESASSSGQRY LDR*VGAGKGA*LF*LRDVVPTSPNLARLSQDQH SRVGNVG**NIHFYLVDASAVEFTVVHSLFSIC *EKLQHHCIILDGNKFE*SDFLQ

Frame 2

GAAGAVAAAEAAAPASAPARARAPAPAPAPAPA RVAVAGAGPGGGGGGRGVGAAALAACGGTCGPT APG*AEGVEALVPGPWC*VSSKSDRGEEAKTRL IVLGCGWLWS*SPGWPLSQPQGGRWCPLCLHW*C LVWWQAPMVTANLSSLKSLRTRLGCQEG*PPSC AKLQENPSRASHG*RRGRKSAPSASRSLSLMMG QGQCFGSSHCGCSEMKPSMSVQLLTAWVRSTLVP SSQCSKRNSCPLGSLPSTWGLS*RWWRRHAQPP CYVPQAEIQTLRFLGSRTSFL*TLPRATAASSS CVQVPCR*RAVRNPTKASTSVWRPTRQAHVTQPL RTCMCECAAWLLVSPSLPAARR*CQAAA*T*HA WQWVHPCPT*SG*WGPRSSPRRMRCQLAATSWS SAMSYALPTTPVWPSPRWA*SRPQPRSQ*KLFQS LRLILW*QRQLPPVSPSPGTLGTRSL*PTMASS TAQRARRAPFRRWMVWPPPATALAASALSRNMP SACWR*TASGEGRPARQCGHARENRRPPAHRAAC RHAC*APAPCWCSGSLPRSPTAWCGDTASTILR TPAAPRTPGTSTTPTRGSSRPWAACCLASPTAC ACLPSPPWAMALPAPPSRSRRSRECLPSPRTSRP RWSRTPGSSSRGCCPLRSGSSCMNWCTGRQRTK TNSTR*PSTQPPPTH*RT*SLTHSTASSWLHAR IWGWASSPPPLRPAQPSPPPPPLPRR*CV*AWAP PRSG*VGSRRLPTAATALSPSTPWPTRRWTART AGGMWWMASAVSTPAGTWWAWRSGRSTGCGCGH TQTWAPAPRAARCWCAPMRTCPAGLRGRWRWSH* TPLLCMSTGSCLSPASSMARSAATRSPTCGWRM ASPVDSPSSKTSC*PRPRKPLSAA*PRRPPTPL LLLPIPPRGMVPAASPKLSLQQVQSQAGPP**SA PRP*TLRCSSGTHPRNCLASCWATGCSTAGPTR RGPTP*ISARMTSTSQSPACTRGPPTSSGLLPR TGLAWVRSSRRRSGPPRTCPAASPKTCM*QD*PR LPQNWPGTRQCWRRGTGASSATPWCSETSTANR SCRTSRQTPALPLLASSQTPLTTSRSAHGPAKA LAHSAPASSPGPCRWSKCLPRTSGWRLQ*RRLCC SAGRFPTPISQLCPLRFCTMGRVWRWTGTRCGS *SQTCSPTQSTRLC**TVAAAQGACSTWCPSAQ PPTSCLTSRCLPLPT*RTAASISPCPMCKTPRLS GGSTLLWCPLTVWAGAC*RQGGAHPRNWSWTSF *KPSSKAERSSGGGGGRQNV*SHMWLLNWMCSR RPLPWGTRRTTGASTTGPCLRT*ATSALCLPP*R NPWTRSAMPPAPTRMRSWSR*HQPSSRRSRRCC G*RVPCWQSSSSSSLSSPSSCSKGKGPTLRPLR MSSRSD*RTPCWPTPLTLWRCGGSTTRPQVCETT HPSPSPTWRTTSSASKPTMASSSPRSMSPSTLD SSSRGRIQTWR*TSPRTAMRMSSPTTTLESSLP LSMASPGVTTSMPTTSMATASRMPTSPRRAPCPR PWVISGGWCGNSARPLWS**HGWRRSPG*NVIS TGQPVAPRPVALFR*PCWTQWSWPHTLCAPSHS TRVAPVRSASCVSFSSWPGQTMEFLSTQLPSWPS YDGSRPATP*TQGPWWCTAARAWAAPAASS*LM PCWSG*STRRRWTSMAT*PACDHRGTTWCRRRT STCSSMRRCWRLPRAATQRCLPATCMPTSRSWAK CLQGRV*PPWSSSSSCWPAPRPTRPASSAPTCP ATSSRTGW*TSCPTN*PVCVCSPSVVWRALTTS MPASWMVIDSRRPT*LHRGLWQRAPRTSGACYGS TIPPSSSC*PSFGRWAGRNATSTGQQSALLATS TLLLTRWLSTTCPSISCVSSRSRMPGMGSQGQS GSSSSQTGQSRACPRQARDSLTSSGRCIRPRSSL DRMGLSRCTAVLAWAAPGCSSL*ASSWSACATR AWSTCFRP*RPCVHSVLPWCRQRTSISCATVRP WSTSAALTTMQRNYRSPLLRHPRRGAPEGTQLL* AIPTIVQPSYADAVTGRAQPTGITAFQERCHTN QRA*NIPGQVDGPAGRHCGPSVHQTHLEPASSS LLRSRISHASSHGVGLGQSLLFNTLSGVD*GILA SSL*FFLSRIRICRMGHCRGWGLFCFVFFF*LL LKDRTLPSSCRAGAASLSGGSAVGREAVLIRLL LQPFRRDPVSAKCRETQCFFKFCFPFKAFF*ATL TVVGGEKIGNTHPWSSIPVCV*HSQPRTTDVSG RAWQGIPHHHRVCKG*NKNKKPQK*KTKKTKNP RKKKRVSPWLLLQTLKRGSNSVCLGFPRELLADL GPQSLALVPSIAVWCGVCRLWGLAVWPR*IAQV RVCATPHAPQGQAGAWLAFQVQASGPGSTCLSS EQGPDDFPPWFAAVFKAPDNRSFPLQDALINQCG KTTGLLSMVL*SVLIIPAC*GAGRAPLPLGSAI *IGKWGRGRVHSCFS*GTWCRRPQT*LG*VKIN IPGLVMLDDETFIFTLWMLVL*SSLLYTVCFLFV KKNYSIIA*FLMVINLNNQISYK

Sequence NM_002840

CGGGAGCGGCGGGAGCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTCCGGCTCCAGC TCGGGTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCGGGGGGACATGCGGACCGACG GCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGACCGGGGTGAAGAAGCAAAGACTCGGTTGA TTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGTGCCTGCACTGGTGATG CTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGT GCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGC AGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCC AAGCTCTCAGTGCTCGAAGAGGAACAGCTGCCCCCTGGGTTCCCTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCA TGCTATGTGCCGCAGGCGGAAATCCAGACCCTGAGATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCT GCGTTCAGGTGCCTTGCAGATAGAGAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTACTCAGCCCCT GCGAACCTGTATGTGCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCG TGGCAGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCTGGAGCT CAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGTGAAAGCTCTTCCAAAG CCTCCGATTGATCTTGTGGTGACAGAGACAACTGCCACCAGTGTCACCCTCACCTGGGACTCTGGGAACTCGGAGCCTGTAACCTACTATGGCATCCAGT ACCGCGCAGCGGGCACGGAGGGCCCCTTTCAGGAGGTGGATGGTGTGGCCACCACCCGCTACAGCATTGGCGGCCTCAGCCCTTTCTCGGAATATGCCTT CCGCGTGCTGGCGGTGAACAGCATCGGGCGAGGGCCGCCCAGCGAGGCAGTGCGGGCACGCACGGGAGAACAGGCGCCCTCCAGCCCACCGCGCCGCGTG CAGGCACGCATGCTGAGCGCCAGCACCATGCTGGTGCAGTGGGAGCCTCCCGAGGAGCCCAACGGCCTGGTGCGGGGATACCGCGTCTACTATACTCCGG ACTCCCGCCGCCCCCCGAACGCCTGGCACAAGCACAACACCGACGCGGGGCTCCTCACGACCGTGGGCAGCCTGCTGCCTGGCATCACCTACAGCCTGCG CGTGCTTGCCTTCACCGCCGTGGGCGATGGCCCTCCCAGCCCCACCATCCAGGTCAAGACGCAGCAGGGAGTGCCTGCCCAGCCCGCGGACTTCCAGGCC GAGGTGGAGTCGGACACCAGGATCCAGCTCTCGTGGCTGCTGCCCCCTCAGGAGCGGATCATCATGTATGAACTGGTGTACTGGGCGGCAGAGGACGAAG ACCAACAGCACAAGGTGACCTTCGACCCAACCTCCTCCTACACACTAGAGGACCTGAAGCCTGACACACTCTACCGCTTCCAGCTGGCTGCACGCTCGGA TATGGGGGTGGGCGTCTTCACCCCCACCATTGAGGCCCGCACAGCCCAGTCCACCCCCTCCGCCCCTCCCCAGAAGGTGATGTGTGTGAGCATGGGCTCC ACCACGGTCCGGGTAAGTTGGGTCCCGCCGCCTGCCGACAGCCGCAACGGCGTTATCACCCAGTACTCCGTGGCCTACGAGGCGGTGGACGGCGAGGACC GCGGGCGGCATGTGGTGGATGGCATCAGCCGTGAGCACTCCAGCTGGGACCTGGTGGGCCTGGAGAAGTGGACGGAGTACCGGGTGTGGGTGCGGGCACA CACAGACGTGGGCCCCGGCCCCGAGAGCAGCCCGGTGCTGGTGCGCACCGATGAGGACGTGCCCAGCGGGCCTCCGCGGAAGGTGGAGGTGGAGCCACTG AACTCCACTGCTGTGCATGTCTACTGGAAGCTGCCTGTCCCCAGCAAGCAGCATGGCCAGATCCGCGGCTACCAGGTCACCTACGTGCGGCTGGAGAATG GCGAGCCCCGTGGACTCCCCATCATCCAAGACGTCATGCTAGCCGAGGCCCAGTGGCGGCCAGAGGAGTCCGAGGACTATGAAACCACTATCAGCGGCCT GACCCCGGAGACCACCTACTCCGTTACTGTTGCTGCCTATACCACCAAGGGGGATGGTGCCCGCAGCAAGCCCAAAATTGTCACTACAACAGGTGCAGTC CCAGGCCGGCCCACCATGATGATCAGCACCACGGCCATGAACACTGCGCTGCTCCAGTGGCACCCACCCAAGGAACTGCCTGGCGAGCTGCTGGGCTACC GGCTGCAGTACTGCCGGGCCGACGAGGCGCGGCCCAACACCATAGATTTCGGCAAGGATGACCAGCACTTCACAGTCACCGGCCTGCACAAGGGGACCAC CTACATCTTCCGGCTTGCTGCCAAGAACCGGGCTGGCTTGGGTGAGGAGTTCGAGAAGGAGATCAGGACCCCCGAGGACCTGCCCAGCGGCTTCCCCCAA AACCTGCATGTGACAGGACTGACCACGTCTACCACAGAACTGGCCTGGGACCCGCCAGTGCTGGCGGAGAGGAACGGGCGCATCATCAGCTACACCGTGG TGTTCCGAGACATCAACAGCCAACAGGAGCTGCAGAACATCACGACAGACACCCGCTTTACCCTTACTGGCCTCAAGCCAGACACCACTTACGACATCAA GGTCCGCGCATGGACCAGCAAAGGCTCTGGCCCACTCAGCCCCAGCATCCAGTCCCGGACCATGCCGGTGGAGCAAGTGTTTGCCAAGAACTTCCGGGTG GCGGCTGCAATGAAGACGTCTGTGCTGCTCAGCTGGGAGGTTCCCGACTCCTATAAGTCAGCTGTGCCCTTTAAGATTCTGTACAATGGGCAGAGTGTGG AGGTGGACGGGCACTCGATGCGGAAGCTGATCGCAGACCTGCAGCCCAACACAGAGTACTCGTTTGTGCTGATGAACCGTGGCAGCAGCGCAGGGGGCCT GCAGCACCTGGTGTCCATCCGCACAGCCCCCGACCTCCTGCCTCACAAGCCGCTGCCTGCCTCTGCCTACATAGAGGACGGCCGCTTCGATCTCTCCATG CCCCATGTGCAAGACCCCTCGCTTGTCAGGTGGTTCTACATTGTTGTGGTGCCCATTGACCGTGTGGGCGGGAGCATGCTGACGCCAAGGTGGAGCACAC CCGAGGAACTGGAGCTGGACGAGCTTCTAGAAGCCATCGAGCAAGGCGGAGAGGAGCAGCGGCGGCGGCGGCGGCAGGCAGAACGTCTGAAGCCATATGT GGCTGCTCAACTGGATGTGCTCCCGGAGACCTTTACCTTGGGGGACAAGAAGAACTACCGGGGCTTCTACAACCGGCCCCTGTCTCCGGACTTGAGCTAC CAGTGCTTTGTGCTTGCCTCCTTGAAGGAACCCATGGACCAGAAGCGCTATGCCTCCAGCCCCTACTCGGATGAGATCGTGGTCCAGGTGACACCAGCCC AGCAGCAGGAGGAGCCGGAGATGCTGTGGGTGACGGGTCCCGTGCTGGCAGTCATCCTCATCATCCTCATTGTCATCGCCATCCTCTTGTTCAAAAGGAA AAGGACCCACTCTCCGTCCTCTAAGGATGAGCAGTCGATCGGACTGAAGGACTCCTTGCTGGCCCACTCCTCTGACCCTGTGGAGATGCGGAGGCTCAAC TACCAGACCCCAGGTATGCGAGACCACCCACCCATCCCCATCACCGACCTGGCGGACAACATCGAGCGCCTCAAAGCCAACGATGGCCTCAAGTTCTCCC AGGAGTATGAGTCCATCGACCCTGGACAGCAGTTCACGTGGGAGAATTCAAACCTGGAGGTGAACAAGCCCAAGAACCGCTATGCGAATGTCATCGCCTA CGACCACTCTCGAGTCATCCTTACCTCTATCGATGGCGTCCCCGGGAGTGACTACATCAATGCCAACTACATCGATGGCTACCGCAAGCAGAATGCCTAC ATCGCCACGCAGGGCCCCCTGCCCGAGACCATGGGTGATTTCTGGAGGATGGTGTGGGAACAGCGCACGGCCACTGTGGTCATGATGACACGGCTGGAGG AGAAGTCCCGGGTAAAATGTGATCAGTACTGGCCAGCCCGTGGCACCGAGACCTGTGGCCTTATTCAGGTGACCCTGTTGGACACAGTGGAGCTGGCCAC ATACACTGTGCGCACCTTCGCACTCCACAAGAGTGGCTCCAGTGAGAAGCGCGAGCTGCGTCAGTTTCAGTTCATGGCCTGGCCAGACCATGGAGTTCCT GAGTACCCAACTCCCATCCTGGCCTTCCTACGACGGGTCAAGGCCTGCAACCCCCTAGACGCAGGGCCCATGGTGGTGCACTGCAGCGCGGGCGTGGGCC GCACCGGCTGCTTCATCGTGATTGATGCCATGTTGGAGCGGATGAAGCACGAGAAGACGGTGGACATCTATGGCCACGTGACCTGCATGCGATCACAGAG GAACTACATGGTGCAGACGGAGGACCAGTACGTGTTCATCCATGAGGCGCTGCTGGAGGCTGCCACGTGCGGCCACACAGAGGTGCCTGCCCGCAACCTG TATGCCCACATCCAGAAGCTGGGCCAAGTGCCTCCAGGGGAGAGTGTGACCGCCATGGAGCTCGAGTTCAAGTTGCTGGCCAGCTCCAAGGCCCACACGT CCCGCTTCATCAGCGCCAACCTGCCCTGCAACAAGTTCAAGAACCGGCTGGTGAACATCATGCCCTACGAATTGACCCGTGTGTGTCTGCAGCCCATCCG TGGTGTGGAGGGCTCTGACTACATCAATGCCAGCTTCCTGGATGGTTATAGACAGCAGAAGGCCTACATAGCTACACAGGGGCCTCTGGCAGAGAGCACC GAGGACTTCTGGCGCATGCTATGGGAGCACAATTCCACCATCATCGTCATGCTGACCAAGCTTCGGGAGATGGGCAGGGAGAAATGCCACCAGTACTGGC CAGCAGAGCGCTCTGCTCGCTACCAGTACTTTGTTGTTGACCCGATGGCTGAGTACAACATGCCCCAGTATATCCTGCGTGAGTTCAAGGTCACGGATGC CCGGGATGGGCAGTCAAGGACAATCCGGCAGTTCCAGTTCACAGACTGGCCAGAGCAGGGCGTGCCCAAGACAGGCGAGGGATTCATTGACTTCATCGGG CAGGTGCATAAGACCAAGGAGCAGTTTGGACAGGATGGGCCTATCACGGTGCACTGCAGTGCTGGCGTGGGCCGCACCGGGGTGTTCATCACTCTGAGCA TCGTCCTGGAGCGCATGCGCTACGAGGGCGTGGTCGACATGTTTCAGACCGTGAAGACCCTGCGTACACAGCGTCCTGCCATGGTGCAGACAGAGGACCA GTATCAGCTGTGCTACCGTGCGGCCCTGGAGTACCTCGGCAGCTTTGACCACTATGCAACGTAACTACCGCTCCCCTCTCCTCCGCCACCCCCGCCGTGG GGCTCCGGAGGGGACCCAGCTCCTCTGAGCCATACCGACCATCGTCCAGCCCTCCTACGCAGATGCTGTCACTGGCAGAGCACAGCCCACGGGGATCACA GCGTTTCAGGAACGTTGCCACACCAATCAGAGAGCCTAGAACATCCCTGGGCAAGTGGATGGCCCAGCAGGCAGGCACTGTGGCCCTTCTGTCCACCAGA CCCACCTGGAGCCCGCTTCAAGCTCTCTGTTGCGCTCCCGCATTTCTCATGCTTCTTCTCATGGGGTGGGGTTGGGGCAAAGCCTCCTTTTTAATACATT AAGTGGGGTAGACTGAGGGATTTTAGCCTCTTCCCTCTGATTTTTCCTTTCGCGAATCCGTATCTGCAGAATGGGCCACTGTAGGGGTTGGGGTTTATTT TGTTTTGTTTTTTTTTTTTGACTTCTGCTGAAGGACAGAACATTGCCTTCCTCGTGCAGAGCTGGGGCTGCCAGCCTGAGCGGAGGCTCGGCCGTGGGCC GGGAGGCAGTGCTGATCCGGCTGCTCCTCCAGCCCTTCAGACGAGATCCTGTTTCAGCTAAATGCAGGGAAACTCAATGTTTTTTTAAGTTTTGTTTTCC CTTTAAAGCCTTTTTTTAGGCCACATTGACAGTGGTGGGCGGGGAGAAGATAGGGAACACTCATCCCTGGTCGTCTATCCCAGTGTGTGTTTAACATTCA CAGCCCAGAACCACAGATGTGTCTGGGAGAGCCTGGCAAGGCATTCCTCATCACCATCGTGTTTGCAAAGGTTAAAACAAAAACAAAAAACCACAAAAAT AAAAAACAAAAAAAACAAAAAACCCAAGAAAAAAAAAAAGAGTCAGCCCTTGGCTTCTGCTTCAAACCCTCAAGAGGGGAAGCAACTCCGTGTGCCTGGG GTTCCCGAGGGAGCTGCTGGCTGACCTGGGCCCACAGAGCCTGGCTTTGGTCCCCAGCATTGCAGTATGGTGTGGTGTTTGTAGGCTGTGGGGTCTGGCT GTGTGGCCAAGGTGAATAGCACAGGTTAGGGTGTGTGCCACACCCCATGCACCTCAGGGCCAAGCGGGGGCGTGGCTGGCCTTTCAGGTCCAGGCCAGTG GGCCTGGTAGCACATGTCTGTCCTCAGAGCAGGGGCCAGATGATTTTCCTCCCTGGTTTGCAGCTGTTTTCAAAGCCCCCGATAATCGCTCTTTTCCACT CCAAGATGCCCTCATAAACCAATGTGGCAAGACTACTGGACTTCTATCAATGGTACTCTAATCAGTCCTTATTATCCCAGCTTGCTGAGGGGCAGGGAGA GCGCCTCTTCCTCTGGGCAGCGCTATCTAGATAGGTAAGTGGGGGCGGGGAAGGGTGCATAGCTGTTTTAGCTGAGGGACGTGGTGCCGACGTCCCCAAA CCTAGCTAGGCTAAGTCAAGATCAACATTCCAGGGTTGGTAATGTTGGATGATGAAACATTCATTTTTACCTTGTGGATGCTAGTGCTGTAGAGTTCACT GTTGTACACAGTCTGTTTTCTATTTGTTAAGAAAAACTACAGCATCATTGCATAATTCTTGATGGTAATAAATTTGAATAATCAGATTTCTTACAAA

refseq_PTPRF.F1 (forward primer)
refseq_PTPRF.R1 (reverse primer)
Single exon skipping

Frame 0

RERRERWRRQRRRLQLRLRLGLGLRLRLRLRLQ LGWRWRERDQVEAAAAEEWEQRP*RLAGGHADRR PLDRRKEWRPWCPALGAEYPARVTGVKKQRLG* LSWAVAGCGARALDGP*ASPREDDGAPCACTGD AWFGGRRPW*QQTCLH*SP*GPDWAVRRGSLLRV PSYRRTQAAHHMDEEGEESQLPALRGH*V**WG RVSASDPAIAGAAR*SHL*VYSY*QPG*DQH*C QALSARRGTAAPWVPFHRHGASAEGGGEGTHSHH AMCRRRKSRP*DFLVQGLPSCRPCHEQRPHQAA AFRCLADREQ*GIRPRQVRVCGDQLGRHTLLSP CEPVCASAPRGSSFLHPSQQPGGDARRQREPDMR GSGCTHALREVDDGGRGAHQGG*DASWPQRPGA QQCRTLCQLHLCGHLLAGHDRGHSPGHSESSSK ASD*SCGDRDNCHQCHPHLGLWELGACNLLWHPV PRSGHGGPLSGGGWCGHHPLQHWRPQPFLGICL PRAGGEQHRARAAQRGSAGTHGRTGALQPTAPR AGTHAERQHHAGAVGASRGAQRPGAGIPRLLYSG LPPPPERLAQAQHRRGAPHDRGQPAAWHHLQPA RACLHRRGRWPSQPHHPGQDAAGSACPARGLPG RGGVGHQDPALVAAAPSGADHHV*TGVLGGRGRR PTAQGDLRPNLLLHTRGPEA*HTLPLPAGCTLG YGGGRLHPHH*GPHSPVHPLRPSPEGDVCEHGL HHGPGKLGPAACRQPQRRYHPVLRGLRGGGRRGP RAACGGWHQP*ALQLGPGGPGEVDGVPGVGAGT HRRGPRPREQPGAGAHR*GRAQRASAEGGGGAT ELHCCACLLEAACPQQAAWPDPRLPGHLRAAGEW RAPWTPHHPRRHASRGPVAARGVRGL*NHYQRP DPGDHLLRYCCCLYHQGGWCPQQAQNCHYNRCS PRPAHHDDQHHGHEHCAAPVAPTQGTAWRAAGLP AAVLPGRRGAAQHHRFRQG*PALHSHRPAQGDH LHLPACCQEPGWLG*GVREGDQDPRGPAQRLPP KPACDRTDHVYHRTGLGPASAGGEERAHHQLHRG VPRHQQPTGAAEHHDRHPLYPYWPQARHHLRHQ GPRMDQQRLWPTQPQHPVPDHAGGASVCQELPG GGCNEDVCAAQLGGSRLL*VSCAL*DSVQWAECG GGRALDAEADRRPAAQHRVLVCADEPWQQRRGP AAPGVHPHSPRPPASQAAACLCLHRGRPLRSLH APCARPLACQVVLHCCGAH*PCGREHADAKVEHT RGTGAGRASRSHRARRRGAAAAAAAGRTSEAIC GCSTGCAPGDLYLGGQEELPGLLQPAPVSGLEL PVLCACLLEGTHGPEALCLQPLLG*DRGPGDTSP AAGGAGDAVGDGSRAGSHPHHPHCHRHPLVQKE KDPLSVL*G*AVDRTEGLLAGPLL*PCGDAEAQ LPDPRYARPPTHPHHRPGGQHRAPQSQRWPQVLP GV*VHRPWTAVHVGEFKPGGEQAQEPLCECHRL RPLSSHPYLYRWRPRE*LHQCQLHRWLPQAECL HRHAGPPARDHG*FLEDGVGTAHGHCGHDDTAGG EVPGKM*SVLASPWHRDLWPYSGDPVGHSGAGH IHCAHLRTPQEWLQ*EARAASVSVHGLARPWSS *VPNSHPGLPTTGQGLQPPRRRAHGGALQRGRGP HRLLHRD*CHVGADEAREDGGHLWPRDLHAITE ELHGADGGPVRVHP*GAAGGCHVRPHRGACPQP VCPHPEAGPSASRGECDRHGARVQVAGQLQGPHV PLHQRQPALQQVQEPAGEHHALRIDPCVSAAHP WCGGL*LHQCQLPGWL*TAEGLHSYTGASGREH RGLLAHAMGAQFHHHRHADQASGDGQGEMPPVLA SRALCSLPVLCC*PDG*VQHAPVYPA*VQGHGC PGWAVKDNPAVPVHRLARAGRAQDRRGIH*LHR AGA*DQGAVWTGWAYHGALQCWRGPHRGVHHSEH RPGAHALRGRGRHVSDREDPAYTASCHGADRGP VSAVLPCGPGVPRQL*PLCNVTTAPLSSATPAV GLRRGPSSSEPYRPSSSPPTQMLSLAEHSPRGSQ RFRNVATPIREPRTSLGKWMAQQAGTVALLSTR PTWSPLQALCCAPAFLMLLLMGWGWGKASFLIH *VG*TEGF*PLPSDFSFRESVSAEWATVGVGVYF VLFFFFDFC*RTEHCLPRAELGLPA*AEARPWA GRQC*SGCSSSPSDEILFQLNAGKLNVFLSFVF PLKPFFRPH*QWWAGRR*GTLIPGRLSQCVFNIH SPEPQMCLGEPGKAFLITIVFAKVKTKTKNHKN KKQKKQKTQEKKKESALGFCFKPSRGEATPCAW GSRGSCWLTWAHRAWLWSPALQYGVVFVGCGVWL CGQGE*HRLGCVPHPMHLRAKRGRGWPFRSRPV GLVAHVCPQSRGQMIFLPGLQLFSKPPIIALFH SKMPS*TNVARLLDFYQWYSNQSLLSQLAEGQGE RLFLWAALSR*VSGGGEGCIAVLAEGRGADVPK PS*AKSRSTFQGW*CWMMKHSFLPCGC*CCRVH CCTQSVFYLLRKTTASLHNS*W**I*IIRFLT

Frame 1

GSGGSGGGGRGGGSSFGSGSGSGSGSGSGSGSS SGGGGGSGTRWRRRRQRSGSSGPSGLRGDMRTD GPWIGGRSGGPGARPLVLSIQQE*PG*RSKDSVD CPGLWLAVELEPWMAPEPAPGRTMVPLVPALVM LGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFV CQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGA GSVLRIQPLRVQRDEAIYECTATNSLGEINTSA KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTAT MLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQL RSGALQIESSEESDQGKYECVATNSAGTRYSAP ANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTC VAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLEL SNVVRSANYTCVAISSLGMIEATAQVTVKALPK PPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQ YRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAF RVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTP DSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLR VLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQA EVESDTRIQLSWLLPPQERIIMYELVYWAAEDE DQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSD MGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGS TTVRVSWVPPPADSRNGVITQYSVAYEAVDGED RGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAH TDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLEN GEPRGLPIIQDVMLAEAQWRPEESEDYETTISGL TPETTYSVTVAAYTTKGDGARSKPKIVTTTGAV PGRPTMMISTTAMNTALLQWHPPKELPGELLGY RLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTT YIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQ NLHVTGLTTSTTELAWDPPVLAERNGRIISYTV VFRDINSQQELQNITTDTRFTLTGLKPDTTYDIK VRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV AAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSV EVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGL QHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSM PHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWST PEELELDELLEAIEQGGEEQRRRRRQAERLKPYV AAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSY QCFVLASLKEPMDQKRYASSPYSDEIVVQVTPA QQQEEPEMLWVTGPVLAVILIILIVIAILLFKRK RTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLN YQTPGMRDHPPIPITDLADNIERLKANDGLKFS QEYESIDPGQQFTWENSNLEVNKPKNRYANVIAY DHSRVILTSIDGVPGSDYINANYIDGYRKQNAY IATQGPLPETMGDFWRMVWEQRTATVVMMTRLE EKSRVKCDQYWPARGTETCGLIQVTLLDTVELAT YTVRTFALHKSGSSEKRELRQFQFMAWPDHGVP EYPTPILAFLRRVKACNPLDAGPMVVHCSAGVG RTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQR NYMVQTEDQYVFIHEALLEAATCGHTEVPARNL YAHIQKLGQVPPGESVTAMELEFKLLASSKAHT SRFISANLPCNKFKNRLVNIMPYELTRVCLQPIR GVEGSDYINASFLDGYRQQKAYIATQGPLAEST EDFWRMLWEHNSTIIVMLTKLREMGREKCHQYW PAERSARYQYFVVDPMAEYNMPQYILREFKVTDA RDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIG QVHKTKEQFGQDGPITVHCSAGVGRTGVFITLS IVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQ YQLCYRAALEYLGSFDHYAT*LPLPSPPPPPPW GSGGDPAPLSHTDHRPALLRRCCHWQSTAHGDH SVSGTLPHQSESLEHPWASGWPSRQALWPFCPPD PPGARFKLSVALPHFSCFFSWGGVGAKPPF*YI KWGRLRDFSLFPLIFPFANPYLQNGPL*GLGFI LFCFFFLTSAEGQNIAFLVQSWGCQPERRLGRGP GGSADPAAPPALQTRSCFS*MQGNSMFF*VLFS L*SLFLGHIDSGGRGEDREHSSLVVYPSVCLTF TAQNHRCVWESLARHSSSPSCLQRLKQKQKTTKI KNKKNKKPKKKKKSQPLASASNPQEGKQLRVPG VPEGAAG*PGPTEPGFGPQHCSMVWCL*AVGSG CVAKVNSTG*GVCHTPCTSGPSGGVAGLSGPGQW AW*HMSVLRAGAR*FSSLVCSCFQSPR*SLFST PRCPHKPMWQDYWTSINGTLISPYYPSLLRGRE SASSSGQRYLDR*VGAGKGA*LF*LRDVVPTSPN LARLSQDQHSRVGNVG**NIHFYLVDASAVEFT VVHSLFSIC*EKLQHHCIILDGNKFE*SDFLQ

Frame 2

GAAGAVAAAEAAAPASAPARARAPAPAPAPAPA RVAVAGAGPGGGGGGRGVGAAALAACGGTCGPT APG*AEGVEALVPGPWC*VSSKSDRGEEAKTRL IVLGCGWLWS*SPGWPLSQPQGGRWCPLCLHW*C LVWWQAPMVTANLSSLKSLRTRLGCQEG*PPSC AKLQENPSRASHG*RRGRKSAPSASRSLSLMMG QGQCFGSSHCGCSEMKPSMSVQLLTAWVRSTLVP SSQCSKRNSCPLGSLPSTWGLS*RWWRRHAQPP CYVPQAEIQTLRFLGSRTSFL*TLPRATAASSS CVQVPCR*RAVRNPTKASTSVWRPTRQAHVTQPL RTCMCECAAWLLVSPSLPAARR*CQAAA*T*HA WQWVHPCPT*SG*WGPRSSPRRMRCQLAATSWS SAMSYALPTTPVWPSPRWA*SRPQPRSQ*KLFQS LRLILW*QRQLPPVSPSPGTLGTRSL*PTMASS TAQRARRAPFRRWMVWPPPATALAASALSRNMP SACWR*TASGEGRPARQCGHARENRRPPAHRAAC RHAC*APAPCWCSGSLPRSPTAWCGDTASTILR TPAAPRTPGTSTTPTRGSSRPWAACCLASPTAC ACLPSPPWAMALPAPPSRSRRSRECLPSPRTSRP RWSRTPGSSSRGCCPLRSGSSCMNWCTGRQRTK TNSTR*PSTQPPPTH*RT*SLTHSTASSWLHAR IWGWASSPPPLRPAQPSPPPPPLPRR*CV*AWAP PRSG*VGSRRLPTAATALSPSTPWPTRRWTART AGGMWWMASAVSTPAGTWWAWRSGRSTGCGCGH TQTWAPAPRAARCWCAPMRTCPAGLRGRWRWSH* TPLLCMSTGSCLSPASSMARSAATRSPTCGWRM ASPVDSPSSKTSC*PRPSGGQRSPRTMKPLSAA *PRRPPTPLLLLPIPPRGMVPAASPKLSLQQVQS QAGPP**SAPRP*TLRCSSGTHPRNCLASCWAT GCSTAGPTRRGPTP*ISARMTSTSQSPACTRGP PTSSGLLPRTGLAWVRSSRRRSGPPRTCPAASPK TCM*QD*PRLPQNWPGTRQCWRRGTGASSATPW CSETSTANRSCRTSRQTPALPLLASSQTPLTTS RSAHGPAKALAHSAPASSPGPCRWSKCLPRTSGW RLQ*RRLCCSAGRFPTPISQLCPLRFCTMGRVW RWTGTRCGS*SQTCSPTQSTRLC**TVAAAQGA CSTWCPSAQPPTSCLTSRCLPLPT*RTAASISPC PMCKTPRLSGGSTLLWCPLTVWAGAC*RQGGAH PRNWSWTSF*KPSSKAERSSGGGGGRQNV*SHM WLLNWMCSRRPLPWGTRRTTGASTTGPCLRT*AT SALCLPP*RNPWTRSAMPPAPTRMRSWSR*HQP SSRRSRRCCG*RVPCWQSSSSSSLSSPSSCSKG KGPTLRPLRMSSRSD*RTPCWPTPLTLWRCGGST TRPQVCETTHPSPSPTWRTTSSASKPTMASSSP RSMSPSTLDSSSRGRIQTWR*TSPRTAMRMSSP TTTLESSLPLSMASPGVTTSMPTTSMATASRMPT SPRRAPCPRPWVISGGWCGNSARPLWS**HGWR RSPG*NVISTGQPVAPRPVALFR*PCWTQWSWP HTLCAPSHSTRVAPVRSASCVSFSSWPGQTMEFL STQLPSWPSYDGSRPATP*TQGPWWCTAARAWA APAASS*LMPCWSG*STRRRWTSMAT*PACDHR GTTWCRRRTSTCSSMRRCWRLPRAATQRCLPATC MPTSRSWAKCLQGRV*PPWSSSSSCWPAPRPTR PASSAPTCPATSSRTGW*TSCPTN*PVCVCSPS VVWRALTTSMPASWMVIDSRRPT*LHRGLWQRAP RTSGACYGSTIPPSSSC*PSFGRWAGRNATSTG QQSALLATSTLLLTRWLSTTCPSISCVSSRSRM PGMGSQGQSGSSSSQTGQSRACPRQARDSLTSSG RCIRPRSSLDRMGLSRCTAVLAWAAPGCSSL*A SSWSACATRAWSTCFRP*RPCVHSVLPWCRQRT SISCATVRPWSTSAALTTMQRNYRSPLLRHPRRG APEGTQLL*AIPTIVQPSYADAVTGRAQPTGIT AFQERCHTNQRA*NIPGQVDGPAGRHCGPSVHQ THLEPASSSLLRSRISHASSHGVGLGQSLLFNTL SGVD*GILASSL*FFLSRIRICRMGHCRGWGLF CFVFFF*LLLKDRTLPSSCRAGAASLSGGSAVG REAVLIRLLLQPFRRDPVSAKCRETQCFFKFCFP FKAFF*ATLTVVGGEKIGNTHPWSSIPVCV*HS QPRTTDVSGRAWQGIPHHHRVCKG*NKNKKPQK *KTKKTKNPRKKKRVSPWLLLQTLKRGSNSVCLG FPRELLADLGPQSLALVPSIAVWCGVCRLWGLA VWPR*IAQVRVCATPHAPQGQAGAWLAFQVQAS GPGSTCLSSEQGPDDFPPWFAAVFKAPDNRSFPL QDALINQCGKTTGLLSMVL*SVLIIPAC*GAGR APLPLGSAI*IGKWGRGRVHSCFS*GTWCRRPQ T*LG*VKINIPGLVMLDDETFIFTLWMLVL*SSL LYTVCFLFVKKNYSIIA*FLMVINLNNQISYK