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Sequences

Sequence NM_130391

GGAGACGTCTGGTGAACACCCGTGGGATCTAAAGAACAAGCTCTGAAAGTGTTCCAGCTGAAATTTCAGATCGGACAGACTCGCTGCGGCTCCGGAGGCA GTGATTCCAAGCTGCTCGCGCACGCTGCTGCCAAGCTGCAGGATGGTGCACGTAGCCAGGCTGCTGCTGCTGCTCCTCACTTTCTTCCTCCGCACGGATG CTGAGACACCTCCAAGGTTTACACGAACACCCGTTGATCAGACAGGGGTCTCTGGCGGAGTTGCCTCTTTCATCTGCCAAGCTACGGGAGACCCAAGACC TAAAATTGTCTGGAACAAAAAAGGAAAGAAAGTCAGCAATCAGAGATTTGAGGTAATAGAGTTTGACGATGGGTCTGGATCAGTTCTCAGAATACAACCC TTACGGACTCCGAGGGATGAGGCCATTTATGAATGTGTGGCCTCAAATAATGTGGGAGAAATAAGTGTATCCACCAGACTCACAGTTTTGCGGGAAGATC AAATTCCCAGGGGCTTCCCTACCATTGACATGGGCCCACAGTTGAAGGTGGTTGAGCGTACTCGCACGGCCACCATGCTTTGTGCAGCCAGTGGTAATCC GGATCCAGAAATCACTTGGTTTAAAGATTTCTTACCTGTGGACACAAGCAACAACAATGGTCGTATTAAGCAGTTACGATCAGGAGCCCTTCAGATTGAG CAGAGTGAAGAGTCTGACCAAGGAAAATATGAGTGTGTTGCCACCAACAGCGCGGGCACTCGCTATTCCGCTCCTGCCAATTTATATGTCAGAGTTCGCC GTGTCCCACCAAGATTCTCTATCCCACCCACTAATCATGAAATCATGCCAGGCGGAAGCGTTAATATCACCTGTGTGGCCGTGGGGTCACCAATGCCTTA TGTAAAGTGGATGTTGGGGGCAGAAGATCTGACACCTGAAGATGATATGCCAATAGGAAGAAATGTGCTAGAACTGAATGATGTAAGACAGTCAGCAAAT TACACCTGTGTTGCTATGTCAACACTGGGTGTCATTGAAGCAATAGCACAGATCACTGTCAAAGCCTTACCCAAACCTCCAGGAACTCCTGTAGTGACCG AGAGCACAGCTACAAGCATCACACTGACGTGGGACTCTGGGAACCCTGAGCCTGTTTCTTATTACATAATTCAGCATAAACCTAAAAACTCTGAGGAACT TTACAAAGAAATTGATGGGGTGGCGACCACACGCTACAGTGTCGCTGGACTAAGTCCCTACTCGGATTATGAATTCAGGGTTGTTGCTGTCAATAACATT GGGCGGGGGCCTCCCAGCGAACCTGTGCTAACACAAACCTCAGAGCAAGCACCATCCAGTGCCCCGAGGGATGTCCAGGCACGAATGTTGAGTTCGACCA CCATTTTGGTACAGTGGAAGGAACCTGAAGAGCCAAATGGACAGATCCAAGGATATAGAGTTTATTATACAATGGATCCCACTCAACATGTCAACAACTG GATGAAACACAATGTAGCTGACAGCCAAATCACTACTATTGGCAACTTAGTGCCCCAGAAAACATATTCTGTCAAAGTCCTGGCTTTTACCTCAATTGGA GATGGTCCCCTTTCAAGTGACATACAAGTCATCACTCAGACAGGAGTACCAGGGCAGCCACTAAACTTCAAAGCAGAACCTGAGTCTGAAACAAGTATTT TGCTCTCTTGGACACCTCCACGTTCAGATACCATTGCCAACTATGAACTGGTCTACAAAGATGGGGAGCATGGAGAGGAGCAACGAATTACCATTGAGCC AGGGACATCATATAGGCTGCAAGGACTGAAACCAAACAGCTTATACTATTTCCGTCTGGCTGCACGCTCCCCTCAAGGCCTGGGTGCTTCTACTGCAGAA ATATCAGCTAGAACCATGCAGTCAAAGCCGTCAGCTCCTCCTCAAGACATTAGTTGCACCAGCCCAAGTTCCACTAGTATTTTGGTAAGTTGGCAACCTC CACCAGTGGAAAAACAGAATGGCATTATCACTGAATACTCCATCAAGTACACTGCAGTGGATGGGGAAGATGACAAGCCTCACGAGATTTTGGGAATTCC TTCGGACACTACCAAATACCTTTTGGAACAGCTGGAAAAATGGACTGAATACCGGATCACTGTGACAGCCCATACAGATGTCGGCCCTGGCCCTGAGAGC TTGTCCGTGTTGATTCGAACCAATGAAGATGTTCCTAGTGGTCCTCCTCGCAAAGTCGAGGTAGAGGCTGTCAACTCAACATCTGTTAAAGTCTCATGGC GCTCACCCGTGCCCAATAAACAGCATGGCCAGATAAGAGGATATCAGGTGCATTATGTGAGGATGGAAAATGGTGAGCCCAAGGGCCAGCCCATGCTGAA AGATGTCATGCTGGCTGATGCACAGTGGGAATTTGATGATACTACTGAACATGACATGATCATTTCTGGGCTCCAGCCTGAAACTTCCTACTCCCTCACC GTCACAGCCTACACAACCAAAGGAGATGGTGCTCGCAGCAAGCCCAAACTGGTGTCCACCACTGGGGCAGTTCCAGGGAAACCTCGGCTTGTGATTAACC ACACTCAGATGAATACTGCTCTTATTCAGTGGCACCCTCCGGTGGACACATTTGGACCTCTTCAGGGCTACCGTCTAAAATTTGGCCGCAAGGATATGGA GCCACTTACTACTCTTGAGTTCTCTGAAAAAGAAGATCACTTTACAGCTACAGACATCCACAAGGGAGCATCATACGTCTTCAGGCTCTCAGCCAGAAAC AAAGTGGGCTTTGGGGAGGAGATGGTGAAGGAGATTTCCATTCCAGAAGAAGTACCAACTGGATTCCCTCAAAACCTTCACTCAGAAGGCACCACTTCAA CCTCCGTCCAGTTATCTTGGCAACCACCTGTCCTGGCAGAGAGAAATGGCATTATCACCAAGTATACCCTTCTTTATAGGGATATCAACATCCCCCTTCT CCCGATGGAGCAGCTTATTGTTCCAGCTGACACCACTATGACACTCACTGGCTTAAAACCAGATACCACATACGATGTAAAAGTACGTGCTCATACGAGC AAAGGGCCCGGGCCATATAGTCCCAGTGTCCAGTTCAGGACACTGCCTGTGGATCAAGTGTTTGCAAAAAATTTTCATGTCAAAGCAGTAATGAAGACTT CCGTGTTGCTGTCTTGGGAGATTCCAGAGAATTATAACTCCGCCATGCCTTTCAAAATTCTTTATGATGATGGGAAAATGGTAGAAGAAGTGGATGGCCG AGCCACACAGAAGTTAATTGTCAACCTGAAGCCTGAGAAATCATATTCATTTGTGCTGACAAATCGTGGAAACAGTGCTGGTGGGCTGCAGCACAGGGTC ACGGCAAAGACTGCACCAGATGTATTACGTACCAAGCCTGCCTTCATTGGGAAGACCAACTTGGATGGCATGATTACTGTGCAACTGCCTGAAGTACCTG CAAATGAGAATATAAAAGGTTACTACATAATAATTGTGCCTTTGAAGAAATCTCGCGGGAAATTTATCAAGCCATGGGAGAGTCCAGATGAAATGGAATT AGATGAGCTGCTTAAGGAGATATCTAGGAAGCGCAGAAGCATCCGTTATGGGAGAGAAGTTGAATTAAAGCCATATATTGCCGCTCACTTTGATGTCCTT CCCACTGAGTTCACCCTGGGGGATGACAAGCATTATGGTGGATTTACAAACAAGCAACTCCAAAGTGGTCAAGAATATGTCTTCTTTGTGTTAGCAGTAA TGGAACATGCAGAGTCTAAGATGTATGCAACCAGCCCTTACTCCGACCCCGTGGTGTCAATGGATCTGGATCCGCAGCCAATCACGGATGAAGAAGAAGG CTTGATCTGGGTTGTAGGTCCTGTCCTTGCAGTGGTCTTTATCATCTGCATTGTCATTGCTATTCTTCTTTATAAAAGGAAGAGGGCAGAGTCCGACTCT AGAAAAAGCAGCATACCGAACAATAAGGAGATCCCTTCACACCACCCAACAGACCCTGTAGAACTGAGGCGCCTTAACTTTCAAACACCGGGTATGGCTA GCCATCCTCCAATACCCATCTTGGAACTTGCAGACCACATTGAAAGATTGAAAGCAAATGACAACTTGAAGTTTTCCCAGGAATATGAGTCAATTGACCC TGGCCAGCAGTTCACTTGGGAACATTCAAACTTGGAAGTAAACAAACCAAAGAATAGATACGCGAATGTAATCGCATATGATCATTCCCGGGTTCTCCTA TCAGCTATAGAAGGGATCCCAGGAAGTGACTATGTGAATGCCAACTACATAGATGGGTATAGGAAGCAAAATGCCTATATTGCAACACAGGGATCTCTCC CCGAAACATTTGGGGACTTTTGGAGAATGATATGGGAACAACGGAGTGCCACAGTTGTCATGATGACAAAACTAGAAGAAAGATCAAGGGTGAAGTGTGA CCAGTATTGGCCTAGCAGAGGCACAGAAACCCACGGACTCGTTCAAGTAACGCTGCTTGATACTGTGGAGCTGGCCACATATTGTGTTCGAACATTTGCA CTTTACAAGAATGGTTCAAGTGAGAAGAGAGAAGTGAGACAATTCCAGTTCACCGCCTGGCCTGATCATGGTGTTCCAGAACACCCTACACCTTTTCTAG CTTTCTTACGTAGAGTCAAAACCTGTAACCCTCCCGATGCTGGTCCGATGGTTGTGCACTGCAGTGCGGGAGTTGGCCGGACTGGTTGCTTCATCGTCAT AGATGCCATGTTAGAAAGAATAAAGCATGAAAAAACTGTAGATATTTATGGCCATGTAACTTTAATGAGAGCCCAGAGGAACTATATGGTTCAAACAGAA GACCAATACATCTTTATCCATGATGCACTGTTAGAAGCAGTGACTTGTGGAAATACCGAAGTGCCAGCTAGAAACTTGTATGCCTACATTCAGAAGCTGA CACAAATAGAAACGGGAGAGAATGTCACAGGAATGGAGCTCGAATTTAAGCGTCTAGCCAGCTCAAAAGCTCACACCTCAAGGTTTATCAGTGCCAATCT TCCATGTAATAAATTCAAAAATCGCCTTGTTAATATTATGCCATATGAATCCACAAGGGTATGCCTGCAGCCTATCCGTGGAGTAGAAGGATCTGATTAC ATCAATGCCAGTTTTATTGATGGATACAGACAACAGAAAGCCTACATCGCTACCCAGGGGCCCTTGGCAGAGACCACTGAAGACTTCTGGCGGATGCTCT GGGAACACAATTCCACCATAGTTGTGATGCTCACCAAGCTGCGTGAAATGGGCAGAGAGAAATGTCACCAATACTGGCCAGCAGAACGGTCTGCAAGATA CCAGTACTTTGTTGTAGATCCCATGGCTGAGTACAACATGCCACAGTATATCCTAAGGGAATTCAAGGTCACAGATGCCAGGGACGGCCAGTCCCGAACA GTAAGGCAGTTCCAGTTCACTGACTGGCCAGAGCAAGGAGTGCCAAAGTCCGGAGAAGGATTTATTGACTTCATCGGCCAAGTCCATAAAACAAAAGAAC AGTTTGGCCAAGATGGACCCATTTCAGTCCATTGCAGCGCGGGCGTTGGAAGAACTGGAGTCTTCATAACGCTAAGCATTGTTTTGGAAAGAATGAGATA TGAAGGAGTTGTAGATATCTTCCAGACTGTCAAAATGTTAAGAACACAACGACCAGCTATGGTACAGACAGAGGATCAATATCAGTTTTCCTATCGTGCC GCACTAGAGTACCTGGGCAGCTTTGACCACTATGCAACGTAGAAACCCCTGACCCATTCTGGATTTTTACTACAGGCCCTTCAATATCCATGGAGTCTCT TCTGAGCCATACAGGGCACTTGAGAAGTCCTTCTTAACTTCTAGCTAACAACTACTTAGTGGGACTATTACACACAAAACAAATTAAAAACAAATTATTC CAGGTGGACCAAGAATTCTTTGACATCGCCCCTTCCCACCATACTGCTCATAATAACATTTTAGGGGGAAAGGGGAGGGAATGTTTAAAAAGAAAGTCCT TGATTTAGTTTTTTAGTATTGTAAAGATACTGCTGACCTGTGCTTCATTTCTAACTGTGTAAACTTTTTTTTAACAAAATGTATCATTCGATAAAGTGAA TTTTAAAAAAGTT

refseq_PTPRD.F3 (forward primer)
refseq_PTPRD.R4 (reverse primer)
Single exon skipping

Frame 0

GDVW*TPVGSKEQALKVFQLKFQIGQTRCGSGG SDSKLLAHAAAKLQDGARSQAAAAAPHFLPPHGC *DTSKVYTNTR*SDRGLWRSCLFHLPSYGRPKT *NCLEQKRKESQQSEI*GNRV*RWVWISSQNTT LTDSEG*GHL*MCGLK*CGRNKCIHQTHSFAGRS NSQGLPYH*HGPTVEGG*AYSHGHHALCSQW*S GSRNHLV*RFLTCGHKQQQWSY*AVTIRSPSD* AE*RV*PRKI*VCCHQQRGHSLFRSCQFICQSSP CPTKILYPTH*S*NHARRKR*YHLCGRGVTNAL CKVDVGGRRSDT*R*YANRKKCARTE*CKTVSK LHLCCYVNTGCH*SNSTDHCQSLTQTSRNSCSDR EHSYKHHTDVGLWEP*ACFLLHNSA*T*KL*GT LQRN*WGGDHTLQCRWTKSLLGL*IQGCCCQ*H WAGASQRTCANTNLRASTIQCPEGCPGTNVEFDH HFGTVEGT*RAKWTDPRI*SLLYNGSHSTCQQL DETQCS*QPNHYYWQLSAPENIFCQSPGFYLNW RWSPFK*HTSHHSDRSTRAATKLQSRT*V*NKYF ALLDTSTFRYHCQL*TGLQRWGAWRGATNYH*A RDII*AARTETKQLILFPSGCTLPSRPGCFYCR NIS*NHAVKAVSSSSRH*LHQPKFH*YFGKLATS TSGKTEWHYH*ILHQVHCSGWGR*QASRDFGNS FGHYQIPFGTAGKMD*IPDHCDSPYRCRPWP*E LVRVDSNQ*RCS*WSSSQSRGRGCQLNIC*SLMA LTRAQ*TAWPDKRISGALCEDGKW*AQGPAHAE RCHAG*CTVGI**YY*T*HDHFWAPA*NFLLPH RHSLHNQRRWCSQQAQTGVHHWGSSRETSACD*P HSDEYCSYSVAPSGGHIWTSSGLPSKIWPQGYG ATYYS*VL*KRRSLYSYRHPQGSIIRLQALSQK QSGLWGGDGEGDFHSRRSTNWIPSKPSLRRHHFN LRPVILATTCPGREKWHYHQVYPSL*GYQHPPS PDGAAYCSS*HHYDTHWLKTRYHIRCKSTCSYE QRARAI*SQCPVQDTACGSSVCKKFSCQSSNEDF RVAVLGDSREL*LRHAFQNSL**WENGRRSGWP SHTEVNCQPEA*EIIFICADKSWKQCWWAAAQG HGKDCTRCITYQACLHWEDQLGWHDYCATA*STC K*EYKRLLHNNCAFEEISREIYQAMGESR*NGI R*AA*GDI*EAQKHPLWERS*IKAIYCRSL*CP SH*VHPGG*QALWWIYKQATPKWSRICLLCVSSN GTCRV*DVCNQPLLRPRGVNGSGSAANHG*RRR LDLGCRSCPCSGLYHLHCHCYSSL*KEEGRVRL *KKQHTEQ*GDPFTPPNRPCRTEAP*LSNTGYG* PSSNTHLGTCRPH*KIESK*QLEVFPGI*VN*P WPAVHLGTFKLGSKQTKE*IRECNRI*SFPGSP ISYRRDPRK*LCECQLHRWV*EAKCLYCNTGISP RNIWGLLENDMGTTECHSCHDDKTRRKIKGEV* PVLA*QRHRNPRTRSSNAA*YCGAGHILCSNIC TLQEWFK*EERSETIPVHRLA*SWCSRTPYTFSS FLT*SQNL*PSRCWSDGCALQCGSWPDWLLHRH RCHVRKNKA*KNCRYLWPCNFNESPEELYGSNR RPIHLYP*CTVRSSDLWKYRSAS*KLVCLHSEAD TNRNGRECHRNGARI*ASSQLKSSHLKVYQCQS SM**IQKSPC*YYAI*IHKGMPAAYPWSRRI*L HQCQFY*WIQTTESLHRYPGALGRDH*RLLADAL GTQFHHSCDAHQAA*NGQREMSPILASRTVCKI PVLCCRSHG*VQHATVYPKGIQGHRCQGRPVPN SKAVPVH*LARARSAKVRRRIY*LHRPSP*NKRT VWPRWTHFSPLQRGRWKNWSLHNAKHCFGKNEI *RSCRYLPDCQNVKNTTTSYGTDRGSISVFLSC RTRVPGQL*PLCNVETPDPFWIFTTGPSISMESL LSHTGHLRSPS*LLANNYLVGLLHTKQIKNKLF QVDQEFFDIAPSHHTAHNNILGGKGRECLKRKS LI*FFSIVKILLTCASFLTV*TFF*QNVSFDKVN FKKV

Frame 1

ETSGEHPWDLKNKL*KCSS*NFRSDRLAAAPEA VIPSCSRTLLPSCRMVHVARLLLLLLTFFLRTD AETPPRFTRTPVDQTGVSGGVASFICQATGDPRP KIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQP LRTPRDEAIYECVASNNVGEISVSTRLTVLRED QIPRGFPTIDMGPQLKVVERTRTATMLCAASGNP DPEITWFKDFLPVDTSNNNGRIKQLRSGALQIE QSEESDQGKYECVATNSAGTRYSAPANLYVRVR RVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPY VKWMLGAEDLTPEDDMPIGRNVLELNDVRQSAN YTCVAMSTLGVIEAIAQITVKALPKPPGTPVVT ESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEL YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNI GRGPPSEPVLTQTSEQAPSSAPRDVQARMLSST TILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNW MKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG DGPLSSDIQVITQTGVPGQPLNFKAEPESETSI LLSWTPPRSDTIANYELVYKDGEHGEEQRITIEP GTSYRLQGLKPNSLYYFRLAARSPQGLGASTAE ISARTMQSKPSAPPQDISCTSPSSTSILVSWQP PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIP SDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSW RSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLK DVMLADAQWEFDDTTEHDMIISGLQPETSYSLT VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVIN HTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDME PLTTLEFSEKEDHFTATDIHKGASYVFRLSARN KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTS TSVQLSWQPPVLAERNGIITKYTLLYRDINIPLL PMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTS KGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKT SVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGR ATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRV TAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVP ANENIKGYYIIIVPLKKSRGKFIKPWESPDEMEL DELLKEISRKRRSIRYGREVELKPYIAAHFDVL PTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAV MEHAESKMYATSPYSDPVVSMDLDPQPITDEEEG LIWVVGPVLAVVFIICIVIAILLYKRKRAESDS RKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMA SHPPIPILELADHIERLKANDNLKFSQEYESIDP GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLL SAIEGIPGSDYVNANYIDGYRKQNAYIATQGSL PETFGDFWRMIWEQRSATVVMMTKLEERSRVKCD QYWPSRGTETHGLVQVTLLDTVELATYCVRTFA LYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFL AFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVI DAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTE DQYIFIHDALLEAVTCGNTEVPARNLYAYIQKL TQIETGENVTGMELEFKRLASSKAHTSRFISANL PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDY INASFIDGYRQQKAYIATQGPLAETTEDFWRML WEHNSTIVVMLTKLREMGREKCHQYWPAERSARY QYFVVDPMAEYNMPQYILREFKVTDARDGQSRT VRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKE QFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRA ALEYLGSFDHYAT*KPLTHSGFLLQALQYPWSL F*AIQGT*EVLLNF*LTTT*WDYYTQNKLKTNYS RWTKNSLTSPLPTILLIITF*GERGGNV*KESP *FSFLVL*RYC*PVLHF*LCKLFFNKMYHSIK* ILKK

Frame 2

RRLVNTRGI*RTSSESVPAEISDRTDSLRLRRQ *FQAARARCCQAAGWCT*PGCCCCSSLSSSARM LRHLQGLHEHPLIRQGSLAELPLSSAKLRETQD LKLSGTKKERKSAIRDLR**SLTMGLDQFSEYNP YGLRGMRPFMNVWPQIMWEK*VYPPDSQFCGKI KFPGASLPLTWAHS*RWLSVLARPPCFVQPVVI RIQKSLGLKISYLWTQATTMVVLSSYDQEPFRLS RVKSLTKENMSVLPPTARALAIPLLPIYMSEFA VSHQDSLSHPLIMKSCQAEALISPVWPWGHQCL M*SGCWGQKI*HLKMICQ*EEMC*N*MM*DSQQI TPVLLCQHWVSLKQ*HRSLSKPYPNLQELL**P RAQLQASH*RGTLGTLSLFLIT*FSINLKTLRN FTKKLMGWRPHATVSLD*VPTRIMNSGLLLSITL GGGLPANLC*HKPQSKHHPVPRGMSRHEC*VRP PFWYSGRNLKSQMDRSKDIEFIIQWIPLNMSTT G*NTM*LTAKSLLLAT*CPRKHILSKSWLLPQLE MVPFQVTYKSSLRQEYQGSH*TSKQNLSLKQVF CSLGHLHVQIPLPTMNWSTKMGSMERSNELPLS QGHHIGCKD*NQTAYTISVWLHAPLKAWVLLLQK YQLEPCSQSRQLLLKTLVAPAQVPLVFW*VGNL HQWKNRMALSLNTPSSTLQWMGKMTSLTRFWEF LRTLPNTFWNSWKNGLNTGSL*QPIQMSALALRA CPC*FEPMKMFLVVLLAKSR*RLSTQHLLKSHG AHPCPINSMAR*EDIRCIM*GWKMVSPRASPC* KMSCWLMHSGNLMILLNMT*SFLGSSLKLPTPSP SQPTQPKEMVLAASPNWCPPLGQFQGNLGL*LT TLR*ILLLFSGTLRWTHLDLFRATV*NLAARIW SHLLLLSSLKKKITLQLQTSTREHHTSSGSQPET KWALGRRW*RRFPFQKKYQLDSLKTFTQKAPLQ PPSSYLGNHLSWQREMALSPSIPFFIGISTSPF SRWSSLLFQLTPL*HSLA*NQIPHTM*KYVLIRA KGPGHIVPVSSSGHCLWIKCLQKIFMSKQ**RL PCCCLGRFQRIITPPCLSKFFMMMGKW*KKWMA EPHRS*LST*SLRNHIHLC*QIVETVLVGCSTGS RQRLHQMYYVPSLPSLGRPTWMA*LLCNCLKYL QMRI*KVTT**LCL*RNLAGNLSSHGRVQMKWN *MSCLRRYLGSAEASVMGEKLN*SHILPLTLMSF PLSSPWGMTSIMVDLQTSNSKVVKNMSSLC*Q* WNMQSLRCMQPALTPTPWCQWIWIRSQSRMKKK A*SGL*VLSLQWSLSSALSLLFFFIKGRGQSPTL EKAAYRTIRRSLHTTQQTL*N*GALTFKHRVWL AILQYPSWNLQTTLKD*KQMTT*SFPRNMSQLT LASSSLGNIQTWK*TNQRIDTRM*SHMIIPGFSY QL*KGSQEVTM*MPTT*MGIGSKMPILQHRDLS PKHLGTFGE*YGNNGVPQLS**QN*KKDQG*SV TSIGLAEAQKPTDSFK*RCLILWSWPHIVFEHLH FTRMVQVRREK*DNSSSPPGLIMVFQNTLHLF* LSYVESKPVTLPMLVRWLCTAVRELAGLVASSS *MPC*KE*SMKKL*IFMAM*L**EPRGTIWFKQK TNTSLSMMHC*KQ*LVEIPKCQLETCMPTFRS* HK*KRERMSQEWSSNLSV*PAQKLTPQGLSVPI FHVINSKIALLILCHMNPQGYACSLSVE*KDLIT SMPVLLMDTDNRKPTSLPRGPWQRPLKTSGGCS GNTIPP*L*CSPSCVKWAERNVTNTGQQNGLQD TSTLL*IPWLSTTCHSIS*GNSRSQMPGTASPEQ *GSSSSLTGQSKECQSPEKDLLTSSAKSIKQKN SLAKMDPFQSIAARALEELESS*R*ALFWKE*D MKEL*ISSRLSKC*EHNDQLWYRQRINISFPIVP H*STWAALTTMQRRNP*PILDFYYRPFNIHGVS SEPYRALEKSFLTSS*QLLSGTITHKTN*KQII PGGPRIL*HRPFPPYCS**HFRGKGEGMFKKKVL DLVF*YCKDTADLCFISNCVNFFLTKCIIR*SE F*KS

Sequence NM_130393

GGAGACGTCTGGTGAACACCCGTGGGATCTAAAGAACAAGCTCTGAAAGTGTTCCAGCTGAAATTTCAGATCGGACAGACTCGCTGCGGCTCCGGAGGCA GTGATTCCAAGCTGCTCGCGCACGCTGCTGCCAAGCTGCAGGATGGTGCACGTAGCCAGGCTGCTGCTGCTGCTCCTCACTTTCTTCCTCCGCACGGATG CTGAGACACCTCCAAGGTTTACACGAACACCCGTTGATCAGACAGGGGTCTCTGGCGGAGTTGCCTCTTTCATCTGCCAAGCTACGGGAGACCCAAGACC TAAAATTGTCTGGAACAAAAAAGGAAAGAAAGTCAGCAATCAGAGATTTGAGGTAATAGAGTTTGACGATGGGTCTGGATCAGTTCTCAGAATACAACCC TTACGGACTCCGAGGGATGAGGCCATTTATGAATGTGTGGCCTCAAATAATGTGGGAGAAATAAGTGTATCCACCAGACTCACAGTTTTGCGGGAAGATC AAATTCCCAGGGGCTTCCCTACCATTGACATGGGCCCACAGTTGAAGGTGGTTGAGCGTACTCGCACGGCCACCATGCTTTGTGCAGCCAGTGGTAATCC GGATCCAGAAATCACTTGGTTTAAAGATTTCTTACCTGTGGACACAAGCAACAACAATGGTCGTATTAAGCAGTTACGATCAGAATCTATTGGTGGTACA CCAATAAGAGGAGCCCTTCAGATTGAGCAGAGTGAAGAGTCTGACCAAGGAAAATATGAGTGTGTTGCCACCAACAGCGCGGGCACTCGCTATTCCGCTC CTGCCAATTTATATGTCAGAGAGCTGCGAGAAGTTCGCCGTGTCCCACCAAGATTCTCTATCCCACCCACTAATCATGAAATCATGCCAGGCGGAAGCGT TAATATCACCTGTGTGGCCGTGGGGTCACCAATGCCTTATGTAAAGTGGATGTTGGGGGCAGAAGATCTGACACCTGAAGATGATATGCCAATAGGAAGA AATGTGCTAGAACTGAATGATGTAAGACAGTCAGCAAATTACACCTGTGTTGCTATGTCAACACTGGGTGTCATTGAAGCAATAGCACAGATCACTGTCA AAGCCTTACCCAAACCTCCAGGAACTCCTGTAGTGACCGAGAGCACAGCTACAAGCATCACACTGACGTGGGACTCTGGGAACCCTGAGCCTGTTTCTTA TTACATAATTCAGCATAAACCTAAAAACTCTGAGGAACTTTACAAAGAAATTGATGGGGTGGCGACCACACGCTACAGTGTCGCTGGACTAAGTCCCTAC TCGGATTATGAATTCAGGGTTGTTGCTGTCAATAACATTGGGCGGGGGCCTCCCAGCGAACCTGTGCTAACACAAACCTCAGAGCAAGCACCATCCAGTG CCCCGAGGGATGTCCAGGCACGAATGTTGAGTTCGACCACCATTTTGGTACAGTGGAAGGAACCTGAAGAGCCAAATGGACAGATCCAAGGATATAGAGT TTATTATACAATGGATCCCACTCAACATGTCAACAACTGGATGAAACACAATGTAGCTGACAGCCAAATCACTACTATTGGCAACTTAGTGCCCCAGAAA ACATATTCTGTCAAAGTCCTGGCTTTTACCTCAATTGGAGATGGTCCCCTTTCAAGTGACATACAAGTCATCACTCAGACAGGAGTACCAGGGCAGCCAC TAAACTTCAAAGCAGAACCTGAGTCTGAAACAAGTATTTTGCTCTCTTGGACACCTCCACGTTCAGATACCATTGCCAACTATGAACTGGTCTACAAAGA TGGGGAGCATGGAGAGGAGCAACGAATTACCATTGAGCCAGGGACATCATATAGGCTGCAAGGACTGAAACCAAACAGCTTATACTATTTCCGTCTGGCT GCACGCTCCCCTCAAGGCCTGGGTGCTTCTACTGCAGAAATATCAGCTAGAACCATGCAGTCAATGTTTGCAAAAAATTTTCATGTCAAAGCAGTAATGA AGACTTCCGTGTTGCTGTCTTGGGAGATTCCAGAGAATTATAACTCCGCCATGCCTTTCAAAATTCTTTATGATGATGGGAAAATGGTAGAAGAAGTGGA TGGCCGAGCCACACAGAAGTTAATTGTCAACCTGAAGCCTGAGAAATCATATTCATTTGTGCTGACAAATCGTGGAAACAGTGCTGGTGGGCTGCAGCAC AGGGTCACGGCAAAGACTGCACCAGATGTATTACGTACCAAGCCTGCCTTCATTGGGAAGACCAACTTGGATGGCATGATTACTGTGCAACTGCCTGAAG TACCTGCAAATGAGAATATAAAAGGTTACTACATAATAATTGTGCCTTTGAAGAAATCTCGCGGGAAATTTATCAAGCCATGGGAGAGTCCAGATGAAAT GGAATTAGATGAGCTGCTTAAGGAGATATCTAGGAAGCGCAGAAGCATCCGTTATGGGAGAGAAGTTGAATTAAAGCCATATATTGCCGCTCACTTTGAT GTCCTTCCCACTGAGTTCACCCTGGGGGATGACAAGCATTATGGTGGATTTACAAACAAGCAACTCCAAAGTGGTCAAGAATATGTCTTCTTTGTGTTAG CAGTAATGGAACATGCAGAGTCTAAGATGTATGCAACCAGCCCTTACTCCGACCCCGTGGTGTCAATGGATCTGGATCCGCAGCCAATCACGGATGAAGA AGAAGGCTTGATCTGGGTTGTAGGTCCTGTCCTTGCAGTGGTCTTTATCATCTGCATTGTCATTGCTATTCTTCTTTATAAAAGGAAGAGGGCAGAGTCC GACTCTAGAAAAAGCAGCATACCGAACAATAAGGAGATCCCTTCACACCACCCAACAGACCCTGTAGAACTGAGGCGCCTTAACTTTCAAACACCGGGTA TGGCTAGCCATCCTCCAATACCCATCTTGGAACTTGCAGACCACATTGAAAGATTGAAAGCAAATGACAACTTGAAGTTTTCCCAGGAATATGAGTCAAT TGACCCTGGCCAGCAGTTCACTTGGGAACATTCAAACTTGGAAGTAAACAAACCAAAGAATAGATACGCGAATGTAATCGCATATGATCATTCCCGGGTT CTCCTATCAGCTATAGAAGGGATCCCAGGAAGTGACTATGTGAATGCCAACTACATAGATGGGTATAGGAAGCAAAATGCCTATATTGCAACACAGGGAT CTCTCCCCGAAACATTTGGGGACTTTTGGAGAATGATATGGGAACAACGGAGTGCCACAGTTGTCATGATGACAAAACTAGAAGAAAGATCAAGGGTGAA GTGTGACCAGTATTGGCCTAGCAGAGGCACAGAAACCCACGGACTCGTTCAAGTAACGCTGCTTGATACTGTGGAGCTGGCCACATATTGTGTTCGAACA TTTGCACTTTACAAGAATGGTTCAAGTGAGAAGAGAGAAGTGAGACAATTCCAGTTCACCGCCTGGCCTGATCATGGTGTTCCAGAACACCCTACACCTT TTCTAGCTTTCTTACGTAGAGTCAAAACCTGTAACCCTCCCGATGCTGGTCCGATGGTTGTGCACTGCAGTGCGGGAGTTGGCCGGACTGGTTGCTTCAT CGTCATAGATGCCATGTTAGAAAGAATAAAGCATGAAAAAACTGTAGATATTTATGGCCATGTAACTTTAATGAGAGCCCAGAGGAACTATATGGTTCAA ACAGAAGACCAATACATCTTTATCCATGATGCACTGTTAGAAGCAGTGACTTGTGGAAATACCGAAGTGCCAGCTAGAAACTTGTATGCCTACATTCAGA AGCTGACACAAATAGAAACGGGAGAGAATGTCACAGGAATGGAGCTCGAATTTAAGCGTCTAGCCAGCTCAAAAGCTCACACCTCAAGGTTTATCAGTGC CAATCTTCCATGTAATAAATTCAAAAATCGCCTTGTTAATATTATGCCATATGAATCCACAAGGGTATGCCTGCAGCCTATCCGTGGAGTAGAAGGATCT GATTACATCAATGCCAGTTTTATTGATGGATACAGACAACAGAAAGCCTACATCGCTACCCAGGGGCCCTTGGCAGAGACCACTGAAGACTTCTGGCGGA TGCTCTGGGAACACAATTCCACCATAGTTGTGATGCTCACCAAGCTGCGTGAAATGGGCAGAGAGAAATGTCACCAATACTGGCCAGCAGAACGGTCTGC AAGATACCAGTACTTTGTTGTAGATCCCATGGCTGAGTACAACATGCCACAGTATATCCTAAGGGAATTCAAGGTCACAGATGCCAGGGACGGCCAGTCC CGAACAGTAAGGCAGTTCCAGTTCACTGACTGGCCAGAGCAAGGAGTGCCAAAGTCCGGAGAAGGATTTATTGACTTCATCGGCCAAGTCCATAAAACAA AAGAACAGTTTGGCCAAGATGGACCCATTTCAGTCCATTGCAGCGCGGGCGTTGGAAGAACTGGAGTCTTCATAACGCTAAGCATTGTTTTGGAAAGAAT GAGATATGAAGGAGTTGTAGATATCTTCCAGACTGTCAAAATGTTAAGAACACAACGACCAGCTATGGTACAGACAGAGGATCAATATCAGTTTTCCTAT CGTGCCGCACTAGAGTACCTGGGCAGCTTTGACCACTATGCAACGTAGAAACCCCTGACCCATTCTGGATTTTTACTACAGGCCCTTCAATATCCATGGA GTCTCTTCTGAGCCATACAGGGCACTTGAGAAGTCCTTCTTAACTTCTAGCTAACAACTACTTAGTGGGACTATTACACACAAAACAAATTAAAAACAAA TTATTCCAGGTGGACCAAGAATTCTTTGACATCGCCCCTTCCCACCATACTGCTCATAATAACATTTTAGGGGGAAAGGGGAGGGAATGTTTAAAAAGAA AGTCCTTGATTTAGTTTTTTAGTATTGTAAAGATACTGCTGACCTGTGCTTCATTTCTAACTGTGTAAACTTTTTTTTAACAAAATGTATCATTCGATAA AGTGAATTTTAAAAAAGTT

refseq_PTPRD.F3 (forward primer)
refseq_PTPRD.R4 (reverse primer)
Single exon skipping

Frame 0

GDVW*TPVGSKEQALKVFQLKFQIGQTRCGSGG SDSKLLAHAAAKLQDGARSQAAAAAPHFLPPHGC *DTSKVYTNTR*SDRGLWRSCLFHLPSYGRPKT *NCLEQKRKESQQSEI*GNRV*RWVWISSQNTT LTDSEG*GHL*MCGLK*CGRNKCIHQTHSFAGRS NSQGLPYH*HGPTVEGG*AYSHGHHALCSQW*S GSRNHLV*RFLTCGHKQQQWSY*AVTIRIYWWY TNKRSPSD*AE*RV*PRKI*VCCHQQRGHSLFRS CQFICQRAARSSPCPTKILYPTH*S*NHARRKR *YHLCGRGVTNALCKVDVGGRRSDT*R*YANRK KCARTE*CKTVSKLHLCCYVNTGCH*SNSTDHCQ SLTQTSRNSCSDREHSYKHHTDVGLWEP*ACFL LHNSA*T*KL*GTLQRN*WGGDHTLQCRWTKSL LGL*IQGCCCQ*HWAGASQRTCANTNLRASTIQC PEGCPGTNVEFDHHFGTVEGT*RAKWTDPRI*S LLYNGSHSTCQQLDETQCS*QPNHYYWQLSAPE NIFCQSPGFYLNWRWSPFK*HTSHHSDRSTRAAT KLQSRT*V*NKYFALLDTSTFRYHCQL*TGLQR WGAWRGATNYH*ARDII*AARTETKQLILFPSG CTLPSRPGCFYCRNIS*NHAVNVCKKFSCQSSNE DFRVAVLGDSREL*LRHAFQNSL**WENGRRSG WPSHTEVNCQPEA*EIIFICADKSWKQCWWAAA QGHGKDCTRCITYQACLHWEDQLGWHDYCATA*S TCK*EYKRLLHNNCAFEEISREIYQAMGESR*N GIR*AA*GDI*EAQKHPLWERS*IKAIYCRSL* CPSH*VHPGG*QALWWIYKQATPKWSRICLLCVS SNGTCRV*DVCNQPLLRPRGVNGSGSAANHG*R RRLDLGCRSCPCSGLYHLHCHCYSSL*KEEGRV RL*KKQHTEQ*GDPFTPPNRPCRTEAP*LSNTGY G*PSSNTHLGTCRPH*KIESK*QLEVFPGI*VN *PWPAVHLGTFKLGSKQTKE*IRECNRI*SFPG SPISYRRDPRK*LCECQLHRWV*EAKCLYCNTGI SPRNIWGLLENDMGTTECHSCHDDKTRRKIKGE V*PVLA*QRHRNPRTRSSNAA*YCGAGHILCSN ICTLQEWFK*EERSETIPVHRLA*SWCSRTPYTF SSFLT*SQNL*PSRCWSDGCALQCGSWPDWLLH RHRCHVRKNKA*KNCRYLWPCNFNESPEELYGS NRRPIHLYP*CTVRSSDLWKYRSAS*KLVCLHSE ADTNRNGRECHRNGARI*ASSQLKSSHLKVYQC QSSM**IQKSPC*YYAI*IHKGMPAAYPWSRRI *LHQCQFY*WIQTTESLHRYPGALGRDH*RLLAD ALGTQFHHSCDAHQAA*NGQREMSPILASRTVC KIPVLCCRSHG*VQHATVYPKGIQGHRCQGRPV PNSKAVPVH*LARARSAKVRRRIY*LHRPSP*NK RTVWPRWTHFSPLQRGRWKNWSLHNAKHCFGKN EI*RSCRYLPDCQNVKNTTTSYGTDRGSISVFL SCRTRVPGQL*PLCNVETPDPFWIFTTGPSISME SLLSHTGHLRSPS*LLANNYLVGLLHTKQIKNK LFQVDQEFFDIAPSHHTAHNNILGGKGRECLKR KSLI*FFSIVKILLTCASFLTV*TFF*QNVSFDK VNFKKV

Frame 1

ETSGEHPWDLKNKL*KCSS*NFRSDRLAAAPEA VIPSCSRTLLPSCRMVHVARLLLLLLTFFLRTD AETPPRFTRTPVDQTGVSGGVASFICQATGDPRP KIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQP LRTPRDEAIYECVASNNVGEISVSTRLTVLRED QIPRGFPTIDMGPQLKVVERTRTATMLCAASGNP DPEITWFKDFLPVDTSNNNGRIKQLRSESIGGT PIRGALQIEQSEESDQGKYECVATNSAGTRYSA PANLYVRELREVRRVPPRFSIPPTNHEIMPGGSV NITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGR NVLELNDVRQSANYTCVAMSTLGVIEAIAQITV KALPKPPGTPVVTESTATSITLTWDSGNPEPVSY YIIQHKPKNSEELYKEIDGVATTRYSVAGLSPY SDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSS APRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV YYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK TYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP LNFKAEPESETSILLSWTPPRSDTIANYELVYKD GEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLA ARSPQGLGASTAEISARTMQSMFAKNFHVKAVM KTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVD GRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQH RVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPE VPANENIKGYYIIIVPLKKSRGKFIKPWESPDEM ELDELLKEISRKRRSIRYGREVELKPYIAAHFD VLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVL AVMEHAESKMYATSPYSDPVVSMDLDPQPITDEE EGLIWVVGPVLAVVFIICIVIAILLYKRKRAES DSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPG MASHPPIPILELADHIERLKANDNLKFSQEYESI DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV LLSAIEGIPGSDYVNANYIDGYRKQNAYIATQG SLPETFGDFWRMIWEQRSATVVMMTKLEERSRVK CDQYWPSRGTETHGLVQVTLLDTVELATYCVRT FALYKNGSSEKREVRQFQFTAWPDHGVPEHPTP FLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFI VIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQ TEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQ KLTQIETGENVTGMELEFKRLASSKAHTSRFISA NLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS DYINASFIDGYRQQKAYIATQGPLAETTEDFWR MLWEHNSTIVVMLTKLREMGREKCHQYWPAERSA RYQYFVVDPMAEYNMPQYILREFKVTDARDGQS RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKT KEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSY RAALEYLGSFDHYAT*KPLTHSGFLLQALQYPW SLF*AIQGT*EVLLNF*LTTT*WDYYTQNKLKTN YSRWTKNSLTSPLPTILLIITF*GERGGNV*KE SP*FSFLVL*RYC*PVLHF*LCKLFFNKMYHSI K*ILKK

Frame 2

RRLVNTRGI*RTSSESVPAEISDRTDSLRLRRQ *FQAARARCCQAAGWCT*PGCCCCSSLSSSARM LRHLQGLHEHPLIRQGSLAELPLSSAKLRETQD LKLSGTKKERKSAIRDLR**SLTMGLDQFSEYNP YGLRGMRPFMNVWPQIMWEK*VYPPDSQFCGKI KFPGASLPLTWAHS*RWLSVLARPPCFVQPVVI RIQKSLGLKISYLWTQATTMVVLSSYDQNLLVVH Q*EEPFRLSRVKSLTKENMSVLPPTARALAIPL LPIYMSESCEKFAVSHQDSLSHPLIMKSCQAEA LISPVWPWGHQCLM*SGCWGQKI*HLKMICQ*EE MC*N*MM*DSQQITPVLLCQHWVSLKQ*HRSLS KPYPNLQELL**PRAQLQASH*RGTLGTLSLFL IT*FSINLKTLRNFTKKLMGWRPHATVSLD*VPT RIMNSGLLLSITLGGGLPANLC*HKPQSKHHPV PRGMSRHEC*VRPPFWYSGRNLKSQMDRSKDIE FIIQWIPLNMSTTG*NTM*LTAKSLLLAT*CPRK HILSKSWLLPQLEMVPFQVTYKSSLRQEYQGSH *TSKQNLSLKQVFCSLGHLHVQIPLPTMNWSTK MGSMERSNELPLSQGHHIGCKD*NQTAYTISVWL HAPLKAWVLLLQKYQLEPCSQCLQKIFMSKQ** RLPCCCLGRFQRIITPPCLSKFFMMMGKW*KKW MAEPHRS*LST*SLRNHIHLC*QIVETVLVGCST GSRQRLHQMYYVPSLPSLGRPTWMA*LLCNCLK YLQMRI*KVTT**LCL*RNLAGNLSSHGRVQMK WN*MSCLRRYLGSAEASVMGEKLN*SHILPLTLM SFPLSSPWGMTSIMVDLQTSNSKVVKNMSSLC* Q*WNMQSLRCMQPALTPTPWCQWIWIRSQSRMK KKA*SGL*VLSLQWSLSSALSLLFFFIKGRGQSP TLEKAAYRTIRRSLHTTQQTL*N*GALTFKHRV WLAILQYPSWNLQTTLKD*KQMTT*SFPRNMSQ LTLASSSLGNIQTWK*TNQRIDTRM*SHMIIPGF SYQL*KGSQEVTM*MPTT*MGIGSKMPILQHRD LSPKHLGTFGE*YGNNGVPQLS**QN*KKDQG* SVTSIGLAEAQKPTDSFK*RCLILWSWPHIVFEH LHFTRMVQVRREK*DNSSSPPGLIMVFQNTLHL F*LSYVESKPVTLPMLVRWLCTAVRELAGLVAS SS*MPC*KE*SMKKL*IFMAM*L**EPRGTIWFK QKTNTSLSMMHC*KQ*LVEIPKCQLETCMPTFR S*HK*KRERMSQEWSSNLSV*PAQKLTPQGLSV PIFHVINSKIALLILCHMNPQGYACSLSVE*KDL ITSMPVLLMDTDNRKPTSLPRGPWQRPLKTSGG CSGNTIPP*L*CSPSCVKWAERNVTNTGQQNGL QDTSTLL*IPWLSTTCHSIS*GNSRSQMPGTASP EQ*GSSSSLTGQSKECQSPEKDLLTSSAKSIKQ KNSLAKMDPFQSIAARALEELESS*R*ALFWKE *DMKEL*ISSRLSKC*EHNDQLWYRQRINISFPI VPH*STWAALTTMQRRNP*PILDFYYRPFNIHG VSSEPYRALEKSFLTSS*QLLSGTITHKTN*KQ IIPGGPRIL*HRPFPPYCS**HFRGKGEGMFKKK VLDLVF*YCKDTADLCFISNCVNFFLTKCIIR* SEF*KS

Sequence NM_130392

GGAGACGTCTGGTGAACACCCGTGGGATCTAAAGAACAAGCTCTGAAAGTGTTCCAGCTGAAATTTCAGATCGGACAGACTCGCTGCGGCTCCGGAGGCA GTGATTCCAAGCTGCTCGCGCACGCTGCTGCCAAGCTGCAGGATGGTGCACGTAGCCAGGCTGCTGCTGCTGCTCCTCACTTTCTTCCTCCGCACGGATG CTGAGACACCTCCAAGGTTTACACGAACACCCGTTGATCAGACAGGGGTCTCTGGCGGAGTTGCCTCTTTCATCTGCCAAGCTACGGGAGACCCAAGACC TAAAATTGTCTGGAACAAAAAAGGAAAGAAAGTCAGCAATCAGAGATTTGAGGTAATAGAGTTTGACGATGGGTCTGGATCAGTTCTCAGAATACAACCC TTACGGACTCCGAGGGATGAGGCCATTTATGAATGTGTGGCCTCAAATAATGTGGGAGAAATAAGTGTATCCACCAGACTCACAGTTTTGCGGGAAGATC AAATTCCCAGGGGCTTCCCTACCATTGACATGGGCCCACAGTTGAAGGTGGTTGAGCGTACTCGCACGGCCACCATGCTTTGTGCAGCCAGTGGTAATCC GGATCCAGAAATCACTTGGTTTAAAGATTTCTTACCTGTGGACACAAGCAACAACAATGGTCGTATTAAGCAGTTACGATCAGAATCTATTGGTGGTACA CCAATAAGAGGAGCCCTTCAGATTGAGCAGAGTGAAGAGTCTGACCAAGGAAAATATGAGTGTGTTGCCACCAACAGCGCGGGCACTCGCTATTCCGCTC CTGCCAATTTATATGTCAGAGAGCTGCGAGAAGTTCGCCGTGTCCCACCAAGATTCTCTATCCCACCCACTAATCATGAAATCATGCCAGGCGGAAGCGT TAATATCACCTGTGTGGCCGTGGGGTCACCAATGCCTTATGTAAAGTGGATGTTGGGGGCAGAAGATCTGACACCTGAAGATGATATGCCAATAGGAAGA AATGTGCTAGAACTGAATGATGTAAGACAGTCAGCAAATTACACCTGTGTTGCTATGTCAACACTGGGTGTCATTGAAGCAATAGCACAGATCACTGTCA AAGCCTTACCCAAACCTCCAGGAACTCCTGTAGTGACCGAGAGCACAGCTACAAGCATCACACTGACGTGGGACTCTGGGAACCCTGAGCCTGTTTCTTA TTACATAATTCAGCATAAACCTAAAAACTCTGAGGAACTTTACAAAGAAATTGATGGGGTGGCGACCACACGCTACAGTGTCGCTGGACTAAGTCCCTAC TCGGATTATGAATTCAGGGTTGTTGCTGTCAATAACATTGGGCGGGGGCCTCCCAGCGAACCTGTGCTAACACAAACCTCAGAGCAAGCACCATCCAGTG CCCCGAGGGATGTCCAGGCACGAATGTTGAGTTCGACCACCATTTTGGTACAGTGGAAGGAACCTGAAGAGCCAAATGGACAGATCCAAGGATATAGAGT TTATTATACAATGGATCCCACTCAACATGTCAACAACTGGATGAAACACAATGTAGCTGACAGCCAAATCACTACTATTGGCAACTTAGTGCCCCAGAAA ACATATTCTGTCAAAGTCCTGGCTTTTACCTCAATTGGAGATGGTCCCCTTTCAAGTGACATACAAGTCATCACTCAGACAGGAGTACCAGGGCAGCCAC TAAACTTCAAAGCAGAACCTGAGTCTGAAACAAGTATTTTGCTCTCTTGGACACCTCCACGTTCAGATACCATTGCCAACTATGAACTGGTCTACAAAGA TGGGGAGCATGGAGAGGAGCAACGAATTACCATTGAGCCAGGGACATCATATAGGCTGCAAGGACTGAAACCAAACAGCTTATACTATTTCCGTCTGGCT GCACGCTCCCCTCAAGGCCTGGGTGCTTCTACTGCAGAAATATCAGCTAGAACCATGCAGTCAAAGCCGTCAGCTCCTCCTCAAGACATTAGTTGCACCA GCCCAAGTTCCACTAGTATTTTGGTAAGTTGGCAACCTCCACCAGTGGAAAAACAGAATGGCATTATCACTGAATACTCCATCAAGTACACTGCAGTGGA TGGGGAAGATGACAAGCCTCACGAGATTTTGGGAATTCCTTCGGACACTACCAAATACCTTTTGGAACAGCTGGAAAAATGGACTGAATACCGGATCACT GTGACAGCCCATACAGATGTCGGCCCTGGCCCTGAGAGCTTGTCCGTGTTGATTCGAACCAATGAAGATGTTCCTAGTGGTCCTCCTCGCAAAGTCGAGG TAGAGGCTGTCAACTCAACATCTGTTAAAGTCTCATGGCGCTCACCCGTGCCCAATAAACAGCATGGCCAGATAAGAGGATATCAGGTGCATTATGTGAG GATGGAAAATGGTGAGCCCAAGGGCCAGCCCATGCTGAAAGATGTCATGCTGGCTGATGCACAGGACATGATCATTTCTGGGCTCCAGCCTGAAACTTCC TACTCCCTCACCGTCACAGCCTACACAACCAAAGGAGATGGTGCTCGCAGCAAGCCCAAACTGGTGTCCACCACTGGGGCAGTTCCAGGGAAACCTCGGC TTGTGATTAACCACACTCAGATGAATACTGCTCTTATTCAGTGGCACCCTCCGGTGGACACATTTGGACCTCTTCAGGGCTACCGTCTAAAATTTGGCCG CAAGGATATGGAGCCACTTACTACTCTTGAGTTCTCTGAAAAAGAAGATCACTTTACAGCTACAGACATCCACAAGGGAGCATCATACGTCTTCAGGCTC TCAGCCAGAAACAAAGTGGGCTTTGGGGAGGAGATGGTGAAGGAGATTTCCATTCCAGAAGAAGTACCAACTGGATTCCCTCAAAACCTTCACTCAGAAG GCACCACTTCAACCTCCGTCCAGTTATCTTGGCAACCACCTGTCCTGGCAGAGAGAAATGGCATTATCACCAAGTATACCCTTCTTTATAGGGATATCAA CATCCCCCTTCTCCCGATGGAGCAGCTTATTGTTCCAGCTGACACCACTATGACACTCACTGGCTTAAAACCAGATACCACATACGATGTAAAAGTACGT GCTCATACGAGCAAAGGGCCCGGGCCATATAGTCCCAGTGTCCAGTTCAGGACACTGCCTGTGGATCAAGTGTTTGCAAAAAATTTTCATGTCAAAGCAG TAATGAAGACTTCCGTGTTGCTGTCTTGGGAGATTCCAGAGAATTATAACTCCGCCATGCCTTTCAAAATTCTTTATGATGATGGGAAAATGGTAGAAGA AGTGGATGGCCGAGCCACACAGAAGTTAATTGTCAACCTGAAGCCTGAGAAATCATATTCATTTGTGCTGACAAATCGTGGAAACAGTGCTGGTGGGCTG CAGCACAGGGTCACGGCAAAGACTGCACCAGATGTATTACGTACCAAGCCTGCCTTCATTGGGAAGACCAACTTGGATGGCATGATTACTGTGCAACTGC CTGAAGTACCTGCAAATGAGAATATAAAAGGTTACTACATAATAATTGTGCCTTTGAAGAAATCTCGCGGGAAATTTATCAAGCCATGGGAGAGTCCAGA TGAAATGGAATTAGATGAGCTGCTTAAGGAGATATCTAGGAAGCGCAGAAGCATCCGTTATGGGAGAGAAGTTGAATTAAAGCCATATATTGCCGCTCAC TTTGATGTCCTTCCCACTGAGTTCACCCTGGGGGATGACAAGCATTATGGTGGATTTACAAACAAGCAACTCCAAAGTGGTCAAGAATATGTCTTCTTTG TGTTAGCAGTAATGGAACATGCAGAGTCTAAGATGTATGCAACCAGCCCTTACTCCGACCCCGTGGTGTCAATGGATCTGGATCCGCAGCCAATCACGGA TGAAGAAGAAGGCTTGATCTGGGTTGTAGGTCCTGTCCTTGCAGTGGTCTTTATCATCTGCATTGTCATTGCTATTCTTCTTTATAAAAGGAAGAGGGCA GAGTCCGACTCTAGAAAAAGCAGCATACCGAACAATAAGGAGATCCCTTCACACCACCCAACAGACCCTGTAGAACTGAGGCGCCTTAACTTTCAAACAC CGGGTATGGCTAGCCATCCTCCAATACCCATCTTGGAACTTGCAGACCACATTGAAAGATTGAAAGCAAATGACAACTTGAAGTTTTCCCAGGAATATGA GTCAATTGACCCTGGCCAGCAGTTCACTTGGGAACATTCAAACTTGGAAGTAAACAAACCAAAGAATAGATACGCGAATGTAATCGCATATGATCATTCC CGGGTTCTCCTATCAGCTATAGAAGGGATCCCAGGAAGTGACTATGTGAATGCCAACTACATAGATGGGTATAGGAAGCAAAATGCCTATATTGCAACAC AGGGATCTCTCCCCGAAACATTTGGGGACTTTTGGAGAATGATATGGGAACAACGGAGTGCCACAGTTGTCATGATGACAAAACTAGAAGAAAGATCAAG GGTGAAGTGTGACCAGTATTGGCCTAGCAGAGGCACAGAAACCCACGGACTCGTTCAAGTAACGCTGCTTGATACTGTGGAGCTGGCCACATATTGTGTT CGAACATTTGCACTTTACAAGAATGGTTCAAGTGAGAAGAGAGAAGTGAGACAATTCCAGTTCACCGCCTGGCCTGATCATGGTGTTCCAGAACACCCTA CACCTTTTCTAGCTTTCTTACGTAGAGTCAAAACCTGTAACCCTCCCGATGCTGGTCCGATGGTTGTGCACTGCAGTGCGGGAGTTGGCCGGACTGGTTG CTTCATCGTCATAGATGCCATGTTAGAAAGAATAAAGCATGAAAAAACTGTAGATATTTATGGCCATGTAACTTTAATGAGAGCCCAGAGGAACTATATG GTTCAAACAGAAGACCAATACATCTTTATCCATGATGCACTGTTAGAAGCAGTGACTTGTGGAAATACCGAAGTGCCAGCTAGAAACTTGTATGCCTACA TTCAGAAGCTGACACAAATAGAAACGGGAGAGAATGTCACAGGAATGGAGCTCGAATTTAAGCGTCTAGCCAGCTCAAAAGCTCACACCTCAAGGTTTAT CAGTGCCAATCTTCCATGTAATAAATTCAAAAATCGCCTTGTTAATATTATGCCATATGAATCCACAAGGGTATGCCTGCAGCCTATCCGTGGAGTAGAA GGATCTGATTACATCAATGCCAGTTTTATTGATGGATACAGACAACAGAAAGCCTACATCGCTACCCAGGGGCCCTTGGCAGAGACCACTGAAGACTTCT GGCGGATGCTCTGGGAACACAATTCCACCATAGTTGTGATGCTCACCAAGCTGCGTGAAATGGGCAGAGAGAAATGTCACCAATACTGGCCAGCAGAACG GTCTGCAAGATACCAGTACTTTGTTGTAGATCCCATGGCTGAGTACAACATGCCACAGTATATCCTAAGGGAATTCAAGGTCACAGATGCCAGGGACGGC CAGTCCCGAACAGTAAGGCAGTTCCAGTTCACTGACTGGCCAGAGCAAGGAGTGCCAAAGTCCGGAGAAGGATTTATTGACTTCATCGGCCAAGTCCATA AAACAAAAGAACAGTTTGGCCAAGATGGACCCATTTCAGTCCATTGCAGCGCGGGCGTTGGAAGAACTGGAGTCTTCATAACGCTAAGCATTGTTTTGGA AAGAATGAGATATGAAGGAGTTGTAGATATCTTCCAGACTGTCAAAATGTTAAGAACACAACGACCAGCTATGGTACAGACAGAGGATCAATATCAGTTT TCCTATCGTGCCGCACTAGAGTACCTGGGCAGCTTTGACCACTATGCAACGTAGAAACCCCTGACCCATTCTGGATTTTTACTACAGGCCCTTCAATATC CATGGAGTCTCTTCTGAGCCATACAGGGCACTTGAGAAGTCCTTCTTAACTTCTAGCTAACAACTACTTAGTGGGACTATTACACACAAAACAAATTAAA AACAAATTATTCCAGGTGGACCAAGAATTCTTTGACATCGCCCCTTCCCACCATACTGCTCATAATAACATTTTAGGGGGAAAGGGGAGGGAATGTTTAA AAAGAAAGTCCTTGATTTAGTTTTTTAGTATTGTAAAGATACTGCTGACCTGTGCTTCATTTCTAACTGTGTAAACTTTTTTTTAACAAAATGTATCATT CGATAAAGTGAATTTTAAAAAAGTT

refseq_PTPRD.F3 (forward primer)
refseq_PTPRD.R4 (reverse primer)
Single exon skipping

Frame 0

GDVW*TPVGSKEQALKVFQLKFQIGQTRCGSGG SDSKLLAHAAAKLQDGARSQAAAAAPHFLPPHGC *DTSKVYTNTR*SDRGLWRSCLFHLPSYGRPKT *NCLEQKRKESQQSEI*GNRV*RWVWISSQNTT LTDSEG*GHL*MCGLK*CGRNKCIHQTHSFAGRS NSQGLPYH*HGPTVEGG*AYSHGHHALCSQW*S GSRNHLV*RFLTCGHKQQQWSY*AVTIRIYWWY TNKRSPSD*AE*RV*PRKI*VCCHQQRGHSLFRS CQFICQRAARSSPCPTKILYPTH*S*NHARRKR *YHLCGRGVTNALCKVDVGGRRSDT*R*YANRK KCARTE*CKTVSKLHLCCYVNTGCH*SNSTDHCQ SLTQTSRNSCSDREHSYKHHTDVGLWEP*ACFL LHNSA*T*KL*GTLQRN*WGGDHTLQCRWTKSL LGL*IQGCCCQ*HWAGASQRTCANTNLRASTIQC PEGCPGTNVEFDHHFGTVEGT*RAKWTDPRI*S LLYNGSHSTCQQLDETQCS*QPNHYYWQLSAPE NIFCQSPGFYLNWRWSPFK*HTSHHSDRSTRAAT KLQSRT*V*NKYFALLDTSTFRYHCQL*TGLQR WGAWRGATNYH*ARDII*AARTETKQLILFPSG CTLPSRPGCFYCRNIS*NHAVKAVSSSSRH*LHQ PKFH*YFGKLATSTSGKTEWHYH*ILHQVHCSG WGR*QASRDFGNSFGHYQIPFGTAGKMD*IPDH CDSPYRCRPWP*ELVRVDSNQ*RCS*WSSSQSRG RGCQLNIC*SLMALTRAQ*TAWPDKRISGALCE DGKW*AQGPAHAERCHAG*CTGHDHFWAPA*NF LLPHRHSLHNQRRWCSQQAQTGVHHWGSSRETSA CD*PHSDEYCSYSVAPSGGHIWTSSGLPSKIWP QGYGATYYS*VL*KRRSLYSYRHPQGSIIRLQA LSQKQSGLWGGDGEGDFHSRRSTNWIPSKPSLRR HHFNLRPVILATTCPGREKWHYHQVYPSL*GYQ HPPSPDGAAYCSS*HHYDTHWLKTRYHIRCKST CSYEQRARAI*SQCPVQDTACGSSVCKKFSCQSS NEDFRVAVLGDSREL*LRHAFQNSL**WENGRR SGWPSHTEVNCQPEA*EIIFICADKSWKQCWWA AAQGHGKDCTRCITYQACLHWEDQLGWHDYCATA *STCK*EYKRLLHNNCAFEEISREIYQAMGESR *NGIR*AA*GDI*EAQKHPLWERS*IKAIYCRS L*CPSH*VHPGG*QALWWIYKQATPKWSRICLLC VSSNGTCRV*DVCNQPLLRPRGVNGSGSAANHG *RRRLDLGCRSCPCSGLYHLHCHCYSSL*KEEG RVRL*KKQHTEQ*GDPFTPPNRPCRTEAP*LSNT GYG*PSSNTHLGTCRPH*KIESK*QLEVFPGI* VN*PWPAVHLGTFKLGSKQTKE*IRECNRI*SF PGSPISYRRDPRK*LCECQLHRWV*EAKCLYCNT GISPRNIWGLLENDMGTTECHSCHDDKTRRKIK GEV*PVLA*QRHRNPRTRSSNAA*YCGAGHILC SNICTLQEWFK*EERSETIPVHRLA*SWCSRTPY TFSSFLT*SQNL*PSRCWSDGCALQCGSWPDWL LHRHRCHVRKNKA*KNCRYLWPCNFNESPEELY GSNRRPIHLYP*CTVRSSDLWKYRSAS*KLVCLH SEADTNRNGRECHRNGARI*ASSQLKSSHLKVY QCQSSM**IQKSPC*YYAI*IHKGMPAAYPWSR RI*LHQCQFY*WIQTTESLHRYPGALGRDH*RLL ADALGTQFHHSCDAHQAA*NGQREMSPILASRT VCKIPVLCCRSHG*VQHATVYPKGIQGHRCQGR PVPNSKAVPVH*LARARSAKVRRRIY*LHRPSP* NKRTVWPRWTHFSPLQRGRWKNWSLHNAKHCFG KNEI*RSCRYLPDCQNVKNTTTSYGTDRGSISV FLSCRTRVPGQL*PLCNVETPDPFWIFTTGPSIS MESLLSHTGHLRSPS*LLANNYLVGLLHTKQIK NKLFQVDQEFFDIAPSHHTAHNNILGGKGRECL KRKSLI*FFSIVKILLTCASFLTV*TFF*QNVSF DKVNFKKV

Frame 1

ETSGEHPWDLKNKL*KCSS*NFRSDRLAAAPEA VIPSCSRTLLPSCRMVHVARLLLLLLTFFLRTD AETPPRFTRTPVDQTGVSGGVASFICQATGDPRP KIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQP LRTPRDEAIYECVASNNVGEISVSTRLTVLRED QIPRGFPTIDMGPQLKVVERTRTATMLCAASGNP DPEITWFKDFLPVDTSNNNGRIKQLRSESIGGT PIRGALQIEQSEESDQGKYECVATNSAGTRYSA PANLYVRELREVRRVPPRFSIPPTNHEIMPGGSV NITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGR NVLELNDVRQSANYTCVAMSTLGVIEAIAQITV KALPKPPGTPVVTESTATSITLTWDSGNPEPVSY YIIQHKPKNSEELYKEIDGVATTRYSVAGLSPY SDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSS APRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV YYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK TYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP LNFKAEPESETSILLSWTPPRSDTIANYELVYKD GEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLA ARSPQGLGASTAEISARTMQSKPSAPPQDISCT SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVD GEDDKPHEILGIPSDTTKYLLEQLEKWTEYRIT VTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVE VEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVR MENGEPKGQPMLKDVMLADAQDMIISGLQPETS YSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPR LVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR KDMEPLTTLEFSEKEDHFTATDIHKGASYVFRL SARNKVGFGEEMVKEISIPEEVPTGFPQNLHSE GTTSTSVQLSWQPPVLAERNGIITKYTLLYRDIN IPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVR AHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKA VMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEE VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGL QHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQL PEVPANENIKGYYIIIVPLKKSRGKFIKPWESPD EMELDELLKEISRKRRSIRYGREVELKPYIAAH FDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFF VLAVMEHAESKMYATSPYSDPVVSMDLDPQPITD EEEGLIWVVGPVLAVVFIICIVIAILLYKRKRA ESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQT PGMASHPPIPILELADHIERLKANDNLKFSQEYE SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHS RVLLSAIEGIPGSDYVNANYIDGYRKQNAYIAT QGSLPETFGDFWRMIWEQRSATVVMMTKLEERSR VKCDQYWPSRGTETHGLVQVTLLDTVELATYCV RTFALYKNGSSEKREVRQFQFTAWPDHGVPEHP TPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYM VQTEDQYIFIHDALLEAVTCGNTEVPARNLYAY IQKLTQIETGENVTGMELEFKRLASSKAHTSRFI SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVE GSDYINASFIDGYRQQKAYIATQGPLAETTEDF WRMLWEHNSTIVVMLTKLREMGREKCHQYWPAER SARYQYFVVDPMAEYNMPQYILREFKVTDARDG QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH KTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE RMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQF SYRAALEYLGSFDHYAT*KPLTHSGFLLQALQY PWSLF*AIQGT*EVLLNF*LTTT*WDYYTQNKLK TNYSRWTKNSLTSPLPTILLIITF*GERGGNV* KESP*FSFLVL*RYC*PVLHF*LCKLFFNKMYH SIK*ILKK

Frame 2

RRLVNTRGI*RTSSESVPAEISDRTDSLRLRRQ *FQAARARCCQAAGWCT*PGCCCCSSLSSSARM LRHLQGLHEHPLIRQGSLAELPLSSAKLRETQD LKLSGTKKERKSAIRDLR**SLTMGLDQFSEYNP YGLRGMRPFMNVWPQIMWEK*VYPPDSQFCGKI KFPGASLPLTWAHS*RWLSVLARPPCFVQPVVI RIQKSLGLKISYLWTQATTMVVLSSYDQNLLVVH Q*EEPFRLSRVKSLTKENMSVLPPTARALAIPL LPIYMSESCEKFAVSHQDSLSHPLIMKSCQAEA LISPVWPWGHQCLM*SGCWGQKI*HLKMICQ*EE MC*N*MM*DSQQITPVLLCQHWVSLKQ*HRSLS KPYPNLQELL**PRAQLQASH*RGTLGTLSLFL IT*FSINLKTLRNFTKKLMGWRPHATVSLD*VPT RIMNSGLLLSITLGGGLPANLC*HKPQSKHHPV PRGMSRHEC*VRPPFWYSGRNLKSQMDRSKDIE FIIQWIPLNMSTTG*NTM*LTAKSLLLAT*CPRK HILSKSWLLPQLEMVPFQVTYKSSLRQEYQGSH *TSKQNLSLKQVFCSLGHLHVQIPLPTMNWSTK MGSMERSNELPLSQGHHIGCKD*NQTAYTISVWL HAPLKAWVLLLQKYQLEPCSQSRQLLLKTLVAP AQVPLVFW*VGNLHQWKNRMALSLNTPSSTLQW MGKMTSLTRFWEFLRTLPNTFWNSWKNGLNTGSL *QPIQMSALALRACPC*FEPMKMFLVVLLAKSR *RLSTQHLLKSHGAHPCPINSMAR*EDIRCIM* GWKMVSPRASPC*KMSCWLMHRT*SFLGSSLKLP TPSPSQPTQPKEMVLAASPNWCPPLGQFQGNLG L*LTTLR*ILLLFSGTLRWTHLDLFRATV*NLA ARIWSHLLLLSSLKKKITLQLQTSTREHHTSSGS QPETKWALGRRW*RRFPFQKKYQLDSLKTFTQK APLQPPSSYLGNHLSWQREMALSPSIPFFIGIS TSPFSRWSSLLFQLTPL*HSLA*NQIPHTM*KYV LIRAKGPGHIVPVSSSGHCLWIKCLQKIFMSKQ **RLPCCCLGRFQRIITPPCLSKFFMMMGKW*K KWMAEPHRS*LST*SLRNHIHLC*QIVETVLVGC STGSRQRLHQMYYVPSLPSLGRPTWMA*LLCNC LKYLQMRI*KVTT**LCL*RNLAGNLSSHGRVQ MKWN*MSCLRRYLGSAEASVMGEKLN*SHILPLT LMSFPLSSPWGMTSIMVDLQTSNSKVVKNMSSL C*Q*WNMQSLRCMQPALTPTPWCQWIWIRSQSR MKKKA*SGL*VLSLQWSLSSALSLLFFFIKGRGQ SPTLEKAAYRTIRRSLHTTQQTL*N*GALTFKH RVWLAILQYPSWNLQTTLKD*KQMTT*SFPRNM SQLTLASSSLGNIQTWK*TNQRIDTRM*SHMIIP GFSYQL*KGSQEVTM*MPTT*MGIGSKMPILQH RDLSPKHLGTFGE*YGNNGVPQLS**QN*KKDQ G*SVTSIGLAEAQKPTDSFK*RCLILWSWPHIVF EHLHFTRMVQVRREK*DNSSSPPGLIMVFQNTL HLF*LSYVESKPVTLPMLVRWLCTAVRELAGLV ASSS*MPC*KE*SMKKL*IFMAM*L**EPRGTIW FKQKTNTSLSMMHC*KQ*LVEIPKCQLETCMPT FRS*HK*KRERMSQEWSSNLSV*PAQKLTPQGL SVPIFHVINSKIALLILCHMNPQGYACSLSVE*K DLITSMPVLLMDTDNRKPTSLPRGPWQRPLKTS GGCSGNTIPP*L*CSPSCVKWAERNVTNTGQQN GLQDTSTLL*IPWLSTTCHSIS*GNSRSQMPGTA SPEQ*GSSSSLTGQSKECQSPEKDLLTSSAKSI KQKNSLAKMDPFQSIAARALEELESS*R*ALFW KE*DMKEL*ISSRLSKC*EHNDQLWYRQRINISF PIVPH*STWAALTTMQRRNP*PILDFYYRPFNI HGVSSEPYRALEKSFLTSS*QLLSGTITHKTN* KQIIPGGPRIL*HRPFPPYCS**HFRGKGEGMFK KKVLDLVF*YCKDTADLCFISNCVNFFLTKCII R*SEF*KS

Sequence NM_002839

GGAGACGTCTGGTGAACACCCGTGGGATCTAAAGAACAAGCTCTGAAAGTGTTCCAGCTGAAATTTCAGATCGGACAGACTCGCTGCGGCTCCGGAGGCA GTGATTCCAAGCTGCTCGCGCACGCTGCTGCCAAGCTGCAGGATGGTGCACGTAGCCAGGCTGCTGCTGCTGCTCCTCACTTTCTTCCTCCGCACGGATG CTGAGACACCTCCAAGGTTTACACGAACACCCGTTGATCAGACAGGGGTCTCTGGCGGAGTTGCCTCTTTCATCTGCCAAGCTACGGGAGACCCAAGACC TAAAATTGTCTGGAACAAAAAAGGAAAGAAAGTCAGCAATCAGAGATTTGAGGTAATAGAGTTTGACGATGGGTCTGGATCAGTTCTCAGAATACAACCC TTACGGACTCCGAGGGATGAGGCCATTTATGAATGTGTGGCCTCAAATAATGTGGGAGAAATAAGTGTATCCACCAGACTCACAGTTTTGCGGGAAGATC AAATTCCCAGGGGCTTCCCTACCATTGACATGGGCCCACAGTTGAAGGTGGTTGAGCGTACTCGCACGGCCACCATGCTTTGTGCAGCCAGTGGTAATCC GGATCCAGAAATCACTTGGTTTAAAGATTTCTTACCTGTGGACACAAGCAACAACAATGGTCGTATTAAGCAGTTACGATCAGAATCTATTGGTGGTACA CCAATAAGAGGAGCCCTTCAGATTGAGCAGAGTGAAGAGTCTGACCAAGGAAAATATGAGTGTGTTGCCACCAACAGCGCGGGCACTCGCTATTCCGCTC CTGCCAATTTATATGTCAGAGAGCTGCGAGAAGTTCGCCGTGTCCCACCAAGATTCTCTATCCCACCCACTAATCATGAAATCATGCCAGGCGGAAGCGT TAATATCACCTGTGTGGCCGTGGGGTCACCAATGCCTTATGTAAAGTGGATGTTGGGGGCAGAAGATCTGACACCTGAAGATGATATGCCAATAGGAAGA AATGTGCTAGAACTGAATGATGTAAGACAGTCAGCAAATTACACCTGTGTTGCTATGTCAACACTGGGTGTCATTGAAGCAATAGCACAGATCACTGTCA AAGCCTTACCCAAACCTCCAGGAACTCCTGTAGTGACCGAGAGCACAGCTACAAGCATCACACTGACGTGGGACTCTGGGAACCCTGAGCCTGTTTCTTA TTACATAATTCAGCATAAACCTAAAAACTCTGAGGAACTTTACAAAGAAATTGATGGGGTGGCGACCACACGCTACAGTGTCGCTGGACTAAGTCCCTAC TCGGATTATGAATTCAGGGTTGTTGCTGTCAATAACATTGGGCGGGGGCCTCCCAGCGAACCTGTGCTAACACAAACCTCAGAGCAAGCACCATCCAGTG CCCCGAGGGATGTCCAGGCACGAATGTTGAGTTCGACCACCATTTTGGTACAGTGGAAGGAACCTGAAGAGCCAAATGGACAGATCCAAGGATATAGAGT TTATTATACAATGGATCCCACTCAACATGTCAACAACTGGATGAAACACAATGTAGCTGACAGCCAAATCACTACTATTGGCAACTTAGTGCCCCAGAAA ACATATTCTGTCAAAGTCCTGGCTTTTACCTCAATTGGAGATGGTCCCCTTTCAAGTGACATACAAGTCATCACTCAGACAGGAGTACCAGGGCAGCCAC TAAACTTCAAAGCAGAACCTGAGTCTGAAACAAGTATTTTGCTCTCTTGGACACCTCCACGTTCAGATACCATTGCCAACTATGAACTGGTCTACAAAGA TGGGGAGCATGGAGAGGAGCAACGAATTACCATTGAGCCAGGGACATCATATAGGCTGCAAGGACTGAAACCAAACAGCTTATACTATTTCCGTCTGGCT GCACGCTCCCCTCAAGGCCTGGGTGCTTCTACTGCAGAAATATCAGCTAGAACCATGCAGTCAAAGCCGTCAGCTCCTCCTCAAGACATTAGTTGCACCA GCCCAAGTTCCACTAGTATTTTGGTAAGTTGGCAACCTCCACCAGTGGAAAAACAGAATGGCATTATCACTGAATACTCCATCAAGTACACTGCAGTGGA TGGGGAAGATGACAAGCCTCACGAGATTTTGGGAATTCCTTCGGACACTACCAAATACCTTTTGGAACAGCTGGAAAAATGGACTGAATACCGGATCACT GTGACAGCCCATACAGATGTCGGCCCTGGCCCTGAGAGCTTGTCCGTGTTGATTCGAACCAATGAAGATGTTCCTAGTGGTCCTCCTCGCAAAGTCGAGG TAGAGGCTGTCAACTCAACATCTGTTAAAGTCTCATGGCGCTCACCCGTGCCCAATAAACAGCATGGCCAGATAAGAGGATATCAGGTGCATTATGTGAG GATGGAAAATGGTGAGCCCAAGGGCCAGCCCATGCTGAAAGATGTCATGCTGGCTGATGCACAGTGGGAATTTGATGATACTACTGAACATGACATGATC ATTTCTGGGCTCCAGCCTGAAACTTCCTACTCCCTCACCGTCACAGCCTACACAACCAAAGGAGATGGTGCTCGCAGCAAGCCCAAACTGGTGTCCACCA CTGGGGCAGTTCCAGGGAAACCTCGGCTTGTGATTAACCACACTCAGATGAATACTGCTCTTATTCAGTGGCACCCTCCGGTGGACACATTTGGACCTCT TCAGGGCTACCGTCTAAAATTTGGCCGCAAGGATATGGAGCCACTTACTACTCTTGAGTTCTCTGAAAAAGAAGATCACTTTACAGCTACAGACATCCAC AAGGGAGCATCATACGTCTTCAGGCTCTCAGCCAGAAACAAAGTGGGCTTTGGGGAGGAGATGGTGAAGGAGATTTCCATTCCAGAAGAAGTACCAACTG GATTCCCTCAAAACCTTCACTCAGAAGGCACCACTTCAACCTCCGTCCAGTTATCTTGGCAACCACCTGTCCTGGCAGAGAGAAATGGCATTATCACCAA GTATACCCTTCTTTATAGGGATATCAACATCCCCCTTCTCCCGATGGAGCAGCTTATTGTTCCAGCTGACACCACTATGACACTCACTGGCTTAAAACCA GATACCACATACGATGTAAAAGTACGTGCTCATACGAGCAAAGGGCCCGGGCCATATAGTCCCAGTGTCCAGTTCAGGACACTGCCTGTGGATCAAGTGT TTGCAAAAAATTTTCATGTCAAAGCAGTAATGAAGACTTCCGTGTTGCTGTCTTGGGAGATTCCAGAGAATTATAACTCCGCCATGCCTTTCAAAATTCT TTATGATGATGGGAAAATGGTAGAAGAAGTGGATGGCCGAGCCACACAGAAGTTAATTGTCAACCTGAAGCCTGAGAAATCATATTCATTTGTGCTGACA AATCGTGGAAACAGTGCTGGTGGGCTGCAGCACAGGGTCACGGCAAAGACTGCACCAGATGTATTACGTACCAAGCCTGCCTTCATTGGGAAGACCAACT TGGATGGCATGATTACTGTGCAACTGCCTGAAGTACCTGCAAATGAGAATATAAAAGGTTACTACATAATAATTGTGCCTTTGAAGAAATCTCGCGGGAA ATTTATCAAGCCATGGGAGAGTCCAGATGAAATGGAATTAGATGAGCTGCTTAAGGAGATATCTAGGAAGCGCAGAAGCATCCGTTATGGGAGAGAAGTT GAATTAAAGCCATATATTGCCGCTCACTTTGATGTCCTTCCCACTGAGTTCACCCTGGGGGATGACAAGCATTATGGTGGATTTACAAACAAGCAACTCC AAAGTGGTCAAGAATATGTCTTCTTTGTGTTAGCAGTAATGGAACATGCAGAGTCTAAGATGTATGCAACCAGCCCTTACTCCGACCCCGTGGTGTCAAT GGATCTGGATCCGCAGCCAATCACGGATGAAGAAGAAGGCTTGATCTGGGTTGTAGGTCCTGTCCTTGCAGTGGTCTTTATCATCTGCATTGTCATTGCT ATTCTTCTTTATAAAAGGAAGAGGGCAGAGTCCGACTCTAGAAAAAGCAGCATACCGAACAATAAGGAGATCCCTTCACACCACCCAACAGACCCTGTAG AACTGAGGCGCCTTAACTTTCAAACACCGGGTATGGCTAGCCATCCTCCAATACCCATCTTGGAACTTGCAGACCACATTGAAAGATTGAAAGCAAATGA CAACTTGAAGTTTTCCCAGGAATATGAGTCAATTGACCCTGGCCAGCAGTTCACTTGGGAACATTCAAACTTGGAAGTAAACAAACCAAAGAATAGATAC GCGAATGTAATCGCATATGATCATTCCCGGGTTCTCCTATCAGCTATAGAAGGGATCCCAGGAAGTGACTATGTGAATGCCAACTACATAGATGGGTATA GGAAGCAAAATGCCTATATTGCAACACAGGGATCTCTCCCCGAAACATTTGGGGACTTTTGGAGAATGATATGGGAACAACGGAGTGCCACAGTTGTCAT GATGACAAAACTAGAAGAAAGATCAAGGGTGAAGTGTGACCAGTATTGGCCTAGCAGAGGCACAGAAACCCACGGACTCGTTCAAGTAACGCTGCTTGAT ACTGTGGAGCTGGCCACATATTGTGTTCGAACATTTGCACTTTACAAGAATGGTTCAAGTGAGAAGAGAGAAGTGAGACAATTCCAGTTCACCGCCTGGC CTGATCATGGTGTTCCAGAACACCCTACACCTTTTCTAGCTTTCTTACGTAGAGTCAAAACCTGTAACCCTCCCGATGCTGGTCCGATGGTTGTGCACTG CAGTGCGGGAGTTGGCCGGACTGGTTGCTTCATCGTCATAGATGCCATGTTAGAAAGAATAAAGCATGAAAAAACTGTAGATATTTATGGCCATGTAACT TTAATGAGAGCCCAGAGGAACTATATGGTTCAAACAGAAGACCAATACATCTTTATCCATGATGCACTGTTAGAAGCAGTGACTTGTGGAAATACCGAAG TGCCAGCTAGAAACTTGTATGCCTACATTCAGAAGCTGACACAAATAGAAACGGGAGAGAATGTCACAGGAATGGAGCTCGAATTTAAGCGTCTAGCCAG CTCAAAAGCTCACACCTCAAGGTTTATCAGTGCCAATCTTCCATGTAATAAATTCAAAAATCGCCTTGTTAATATTATGCCATATGAATCCACAAGGGTA TGCCTGCAGCCTATCCGTGGAGTAGAAGGATCTGATTACATCAATGCCAGTTTTATTGATGGATACAGACAACAGAAAGCCTACATCGCTACCCAGGGGC CCTTGGCAGAGACCACTGAAGACTTCTGGCGGATGCTCTGGGAACACAATTCCACCATAGTTGTGATGCTCACCAAGCTGCGTGAAATGGGCAGAGAGAA ATGTCACCAATACTGGCCAGCAGAACGGTCTGCAAGATACCAGTACTTTGTTGTAGATCCCATGGCTGAGTACAACATGCCACAGTATATCCTAAGGGAA TTCAAGGTCACAGATGCCAGGGACGGCCAGTCCCGAACAGTAAGGCAGTTCCAGTTCACTGACTGGCCAGAGCAAGGAGTGCCAAAGTCCGGAGAAGGAT TTATTGACTTCATCGGCCAAGTCCATAAAACAAAAGAACAGTTTGGCCAAGATGGACCCATTTCAGTCCATTGCAGCGCGGGCGTTGGAAGAACTGGAGT CTTCATAACGCTAAGCATTGTTTTGGAAAGAATGAGATATGAAGGAGTTGTAGATATCTTCCAGACTGTCAAAATGTTAAGAACACAACGACCAGCTATG GTACAGACAGAGGATCAATATCAGTTTTCCTATCGTGCCGCACTAGAGTACCTGGGCAGCTTTGACCACTATGCAACGTAGAAACCCCTGACCCATTCTG GATTTTTACTACAGGCCCTTCAATATCCATGGAGTCTCTTCTGAGCCATACAGGGCACTTGAGAAGTCCTTCTTAACTTCTAGCTAACAACTACTTAGTG GGACTATTACACACAAAACAAATTAAAAACAAATTATTCCAGGTGGACCAAGAATTCTTTGACATCGCCCCTTCCCACCATACTGCTCATAATAACATTT TAGGGGGAAAGGGGAGGGAATGTTTAAAAAGAAAGTCCTTGATTTAGTTTTTTAGTATTGTAAAGATACTGCTGACCTGTGCTTCATTTCTAACTGTGTA AACTTTTTTTTAACAAAATGTATCATTCGATAAAGTGAATTTTAAAAAAGTT

refseq_PTPRD.F3 (forward primer)
refseq_PTPRD.R4 (reverse primer)
Single exon skipping

Frame 0

GDVW*TPVGSKEQALKVFQLKFQIGQTRCGSGG SDSKLLAHAAAKLQDGARSQAAAAAPHFLPPHGC *DTSKVYTNTR*SDRGLWRSCLFHLPSYGRPKT *NCLEQKRKESQQSEI*GNRV*RWVWISSQNTT LTDSEG*GHL*MCGLK*CGRNKCIHQTHSFAGRS NSQGLPYH*HGPTVEGG*AYSHGHHALCSQW*S GSRNHLV*RFLTCGHKQQQWSY*AVTIRIYWWY TNKRSPSD*AE*RV*PRKI*VCCHQQRGHSLFRS CQFICQRAARSSPCPTKILYPTH*S*NHARRKR *YHLCGRGVTNALCKVDVGGRRSDT*R*YANRK KCARTE*CKTVSKLHLCCYVNTGCH*SNSTDHCQ SLTQTSRNSCSDREHSYKHHTDVGLWEP*ACFL LHNSA*T*KL*GTLQRN*WGGDHTLQCRWTKSL LGL*IQGCCCQ*HWAGASQRTCANTNLRASTIQC PEGCPGTNVEFDHHFGTVEGT*RAKWTDPRI*S LLYNGSHSTCQQLDETQCS*QPNHYYWQLSAPE NIFCQSPGFYLNWRWSPFK*HTSHHSDRSTRAAT KLQSRT*V*NKYFALLDTSTFRYHCQL*TGLQR WGAWRGATNYH*ARDII*AARTETKQLILFPSG CTLPSRPGCFYCRNIS*NHAVKAVSSSSRH*LHQ PKFH*YFGKLATSTSGKTEWHYH*ILHQVHCSG WGR*QASRDFGNSFGHYQIPFGTAGKMD*IPDH CDSPYRCRPWP*ELVRVDSNQ*RCS*WSSSQSRG RGCQLNIC*SLMALTRAQ*TAWPDKRISGALCE DGKW*AQGPAHAERCHAG*CTVGI**YY*T*HD HFWAPA*NFLLPHRHSLHNQRRWCSQQAQTGVHH WGSSRETSACD*PHSDEYCSYSVAPSGGHIWTS SGLPSKIWPQGYGATYYS*VL*KRRSLYSYRHP QGSIIRLQALSQKQSGLWGGDGEGDFHSRRSTNW IPSKPSLRRHHFNLRPVILATTCPGREKWHYHQ VYPSL*GYQHPPSPDGAAYCSS*HHYDTHWLKT RYHIRCKSTCSYEQRARAI*SQCPVQDTACGSSV CKKFSCQSSNEDFRVAVLGDSREL*LRHAFQNS L**WENGRRSGWPSHTEVNCQPEA*EIIFICAD KSWKQCWWAAAQGHGKDCTRCITYQACLHWEDQL GWHDYCATA*STCK*EYKRLLHNNCAFEEISRE IYQAMGESR*NGIR*AA*GDI*EAQKHPLWERS *IKAIYCRSL*CPSH*VHPGG*QALWWIYKQATP KWSRICLLCVSSNGTCRV*DVCNQPLLRPRGVN GSGSAANHG*RRRLDLGCRSCPCSGLYHLHCHC YSSL*KEEGRVRL*KKQHTEQ*GDPFTPPNRPCR TEAP*LSNTGYG*PSSNTHLGTCRPH*KIESK* QLEVFPGI*VN*PWPAVHLGTFKLGSKQTKE*I RECNRI*SFPGSPISYRRDPRK*LCECQLHRWV* EAKCLYCNTGISPRNIWGLLENDMGTTECHSCH DDKTRRKIKGEV*PVLA*QRHRNPRTRSSNAA* YCGAGHILCSNICTLQEWFK*EERSETIPVHRLA *SWCSRTPYTFSSFLT*SQNL*PSRCWSDGCAL QCGSWPDWLLHRHRCHVRKNKA*KNCRYLWPCN FNESPEELYGSNRRPIHLYP*CTVRSSDLWKYRS AS*KLVCLHSEADTNRNGRECHRNGARI*ASSQ LKSSHLKVYQCQSSM**IQKSPC*YYAI*IHKG MPAAYPWSRRI*LHQCQFY*WIQTTESLHRYPGA LGRDH*RLLADALGTQFHHSCDAHQAA*NGQRE MSPILASRTVCKIPVLCCRSHG*VQHATVYPKG IQGHRCQGRPVPNSKAVPVH*LARARSAKVRRRI Y*LHRPSP*NKRTVWPRWTHFSPLQRGRWKNWS LHNAKHCFGKNEI*RSCRYLPDCQNVKNTTTSY GTDRGSISVFLSCRTRVPGQL*PLCNVETPDPFW IFTTGPSISMESLLSHTGHLRSPS*LLANNYLV GLLHTKQIKNKLFQVDQEFFDIAPSHHTAHNNI LGGKGRECLKRKSLI*FFSIVKILLTCASFLTV* TFF*QNVSFDKVNFKKV

Frame 1

ETSGEHPWDLKNKL*KCSS*NFRSDRLAAAPEA VIPSCSRTLLPSCRMVHVARLLLLLLTFFLRTD AETPPRFTRTPVDQTGVSGGVASFICQATGDPRP KIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQP LRTPRDEAIYECVASNNVGEISVSTRLTVLRED QIPRGFPTIDMGPQLKVVERTRTATMLCAASGNP DPEITWFKDFLPVDTSNNNGRIKQLRSESIGGT PIRGALQIEQSEESDQGKYECVATNSAGTRYSA PANLYVRELREVRRVPPRFSIPPTNHEIMPGGSV NITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGR NVLELNDVRQSANYTCVAMSTLGVIEAIAQITV KALPKPPGTPVVTESTATSITLTWDSGNPEPVSY YIIQHKPKNSEELYKEIDGVATTRYSVAGLSPY SDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSS APRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV YYTMDPTQHVNNWMKHNVADSQITTIGNLVPQK TYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP LNFKAEPESETSILLSWTPPRSDTIANYELVYKD GEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLA ARSPQGLGASTAEISARTMQSKPSAPPQDISCT SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVD GEDDKPHEILGIPSDTTKYLLEQLEKWTEYRIT VTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVE VEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVR MENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI ISGLQPETSYSLTVTAYTTKGDGARSKPKLVST TGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPL QGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIH KGASYVFRLSARNKVGFGEEMVKEISIPEEVPT GFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITK YTLLYRDINIPLLPMEQLIVPADTTMTLTGLKP DTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQV FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKIL YDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLT NRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTN LDGMITVQLPEVPANENIKGYYIIIVPLKKSRGK FIKPWESPDEMELDELLKEISRKRRSIRYGREV ELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQL QSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSM DLDPQPITDEEEGLIWVVGPVLAVVFIICIVIA ILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPV ELRRLNFQTPGMASHPPIPILELADHIERLKAND NLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRY ANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGY RKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLD TVELATYCVRTFALYKNGSSEKREVRQFQFTAW PDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHC SAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVT LMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTE VPARNLYAYIQKLTQIETGENVTGMELEFKRLAS SKAHTSRFISANLPCNKFKNRLVNIMPYESTRV CLQPIRGVEGSDYINASFIDGYRQQKAYIATQG PLAETTEDFWRMLWEHNSTIVVMLTKLREMGREK CHQYWPAERSARYQYFVVDPMAEYNMPQYILRE FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEG FIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGV FITLSIVLERMRYEGVVDIFQTVKMLRTQRPAM VQTEDQYQFSYRAALEYLGSFDHYAT*KPLTHS GFLLQALQYPWSLF*AIQGT*EVLLNF*LTTT*W DYYTQNKLKTNYSRWTKNSLTSPLPTILLIITF *GERGGNV*KESP*FSFLVL*RYC*PVLHF*LC KLFFNKMYHSIK*ILKK

Frame 2

RRLVNTRGI*RTSSESVPAEISDRTDSLRLRRQ *FQAARARCCQAAGWCT*PGCCCCSSLSSSARM LRHLQGLHEHPLIRQGSLAELPLSSAKLRETQD LKLSGTKKERKSAIRDLR**SLTMGLDQFSEYNP YGLRGMRPFMNVWPQIMWEK*VYPPDSQFCGKI KFPGASLPLTWAHS*RWLSVLARPPCFVQPVVI RIQKSLGLKISYLWTQATTMVVLSSYDQNLLVVH Q*EEPFRLSRVKSLTKENMSVLPPTARALAIPL LPIYMSESCEKFAVSHQDSLSHPLIMKSCQAEA LISPVWPWGHQCLM*SGCWGQKI*HLKMICQ*EE MC*N*MM*DSQQITPVLLCQHWVSLKQ*HRSLS KPYPNLQELL**PRAQLQASH*RGTLGTLSLFL IT*FSINLKTLRNFTKKLMGWRPHATVSLD*VPT RIMNSGLLLSITLGGGLPANLC*HKPQSKHHPV PRGMSRHEC*VRPPFWYSGRNLKSQMDRSKDIE FIIQWIPLNMSTTG*NTM*LTAKSLLLAT*CPRK HILSKSWLLPQLEMVPFQVTYKSSLRQEYQGSH *TSKQNLSLKQVFCSLGHLHVQIPLPTMNWSTK MGSMERSNELPLSQGHHIGCKD*NQTAYTISVWL HAPLKAWVLLLQKYQLEPCSQSRQLLLKTLVAP AQVPLVFW*VGNLHQWKNRMALSLNTPSSTLQW MGKMTSLTRFWEFLRTLPNTFWNSWKNGLNTGSL *QPIQMSALALRACPC*FEPMKMFLVVLLAKSR *RLSTQHLLKSHGAHPCPINSMAR*EDIRCIM* GWKMVSPRASPC*KMSCWLMHSGNLMILLNMT*S FLGSSLKLPTPSPSQPTQPKEMVLAASPNWCPP LGQFQGNLGL*LTTLR*ILLLFSGTLRWTHLDL FRATV*NLAARIWSHLLLLSSLKKKITLQLQTST REHHTSSGSQPETKWALGRRW*RRFPFQKKYQL DSLKTFTQKAPLQPPSSYLGNHLSWQREMALSP SIPFFIGISTSPFSRWSSLLFQLTPL*HSLA*NQ IPHTM*KYVLIRAKGPGHIVPVSSSGHCLWIKC LQKIFMSKQ**RLPCCCLGRFQRIITPPCLSKF FMMMGKW*KKWMAEPHRS*LST*SLRNHIHLC*Q IVETVLVGCSTGSRQRLHQMYYVPSLPSLGRPT WMA*LLCNCLKYLQMRI*KVTT**LCL*RNLAG NLSSHGRVQMKWN*MSCLRRYLGSAEASVMGEKL N*SHILPLTLMSFPLSSPWGMTSIMVDLQTSNS KVVKNMSSLC*Q*WNMQSLRCMQPALTPTPWCQ WIWIRSQSRMKKKA*SGL*VLSLQWSLSSALSLL FFFIKGRGQSPTLEKAAYRTIRRSLHTTQQTL* N*GALTFKHRVWLAILQYPSWNLQTTLKD*KQM TT*SFPRNMSQLTLASSSLGNIQTWK*TNQRIDT RM*SHMIIPGFSYQL*KGSQEVTM*MPTT*MGI GSKMPILQHRDLSPKHLGTFGE*YGNNGVPQLS **QN*KKDQG*SVTSIGLAEAQKPTDSFK*RCLI LWSWPHIVFEHLHFTRMVQVRREK*DNSSSPPG LIMVFQNTLHLF*LSYVESKPVTLPMLVRWLCT AVRELAGLVASSS*MPC*KE*SMKKL*IFMAM*L **EPRGTIWFKQKTNTSLSMMHC*KQ*LVEIPK CQLETCMPTFRS*HK*KRERMSQEWSSNLSV*P AQKLTPQGLSVPIFHVINSKIALLILCHMNPQGY ACSLSVE*KDLITSMPVLLMDTDNRKPTSLPRG PWQRPLKTSGGCSGNTIPP*L*CSPSCVKWAER NVTNTGQQNGLQDTSTLL*IPWLSTTCHSIS*GN SRSQMPGTASPEQ*GSSSSLTGQSKECQSPEKD LLTSSAKSIKQKNSLAKMDPFQSIAARALEELE SS*R*ALFWKE*DMKEL*ISSRLSKC*EHNDQLW YRQRINISFPIVPH*STWAALTTMQRRNP*PIL DFYYRPFNIHGVSSEPYRALEKSFLTSS*QLLS GTITHKTN*KQIIPGGPRIL*HRPFPPYCS**HF RGKGEGMFKKKVLDLVF*YCKDTADLCFISNCV NFFLTKCIIR*SEF*KS