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Sequence NM_001003712
CACTAGAATGTGAAGGATCTTCGCGGTTCTGGGTGCCCAGAAAGGCGGCGACGCGGCGGATGACAACATTAGGCCGCGACGCGCTCCTGGCCAGGCGGCGGCTGTAGTGTTAGCTTTGGACGCCGCAGTAGCCGCTGCCGGTAGCAAGCCGACTGAGGGAAGGTGGGGGTCCGCCCGGGCTGGTGGACCTCGGGGCCGAA
AGTTCCCGCCCCGCTCGGGGGCTGAGCCGGCAGTGCCTCCGCGGCCGCTGGGCAGCGCCCTTCGTCCAGGCTCGCGCCCCAGCTGCCGCCGACGACAGCG
GCCGAGAGAAGTTGGGGTCTGACTAGACGCTTACGGGGCCTCGGACCCCGGCGCCGCGGCGACCTCGGAGGAACCGGCTCCTTGCGTCCCGCCTCCCTGG
GAGCTCCGCACGGGATTTGCAGATTTACAGAATGGCTGCACATTAATGGAAAGAGAAGCATAAACCTATCTTCTTTCATTATGGAGGGAGGTTTGGCAGA
TGGAGAACCTGATCGAACTTCGCAAACAGTGACGAATCTCAGCTTCTGACACCAGGAAAGATGAGTCAGCGCCAAGGAAAAGAAGCTTATCCAACGCCAA
CCAAAGATTTGCATCAGCCATCTCTTAGTCCAGCAAGTCCTCATAGCCAGGGTTTTGAAAGAGGGAAGGAAGATATTTCTCAAAATAAAGATGAATCTTC
ACTTTCTATGTCAAAGAGCAAGTCTGAATCTAAACTTTATAATGGCTCAGAGAAGGACAGTTCAACTTCAAGCAAACTCACAAAAAAAGAATCTCTTAAG
GTACAAAAGAAAAATTACCGAGAAGAAAAGAAAAGAGCCACAAAGGAGCTGCTCAGTACAATCACAGATCCTTCTGTTATTGTTATGGCTGATTGGTTAA
AGATTCGTGGTACTCTAAAGAGCTGGACCAAGTTATGGTGTGTGTTGAAACCTGGGGTGCTACTGATCTATAAAACCCAAAAAAATGGTCAGTGGGTAGG
AACAGTTCTTCTGAATGCCTGTGAAATCATTGAACGTCCATCAAAAAAGGATGGCTTTTGTTTCAAACTTTTCCATCCTTTGGAGCAATCTATTTGGGCA
GTGAAGGGTCCAAAAGGTGAAGCGGTTGGATCCATTACTCAACCCTTACCTAGCAGTTATTTGATCATCCGAGCTACTTCAGAGTCAGATGGAAGGTGCT
GGATGGATGCTTTGGAGTTGGCTTTGAAATGTTCTAGTCTTCTTAAACGTACAATGATCAGAGAAGGAAAGGAACATGACCTGAGCGTTTCATCAGATAG
CACACATGTGACTTTCTATGGCTTACTACGTGCTAACAATCTCCACAGTGGTGATAACTTCCAGTTAAATGATAGTGAAATTGAACGACAACATTTTAAG
GACCAAGATATGTATTCTGATAAATCTGATAAAGAAAATGATCAAGAACATGATGAGTCTGATAATGAGGTGATGGGGAAAAGTGAAGAAAGTGACACAG
ATACATCAGAAAGACAAGATGACTCATATATCGAACCTGAGCCTGTTGAGCCTTTAAAGGAGACTACCTACACTGAACAGAGCCATGAAGAACTTGGAGA
GGCAGGTGAGGCTTCTCAAACAGAAACTGTATCTGAAGAAAACAAAAGCCTTATCTGGACACTATTGAAACAAGTCCGTCCTGGCATGGACCTATCCAAG
GTGGTTCTGCCTACATTTATTTTGGAACCCCGTTCTTTCCTGGATAAACTTTCAGATTACTACTATCATGCAGATTTCCTATCTGAGGCAGCTCTTGAAG
AAAATCCTTATTTCCGTTTGAAGAAAGTAGTGAAATGGTATTTGTCAGGATTCTATAAAAAGCCAAAGGGACTGAAGAAACCTTATAATCCTATACTTGG
CGAGACTTTCCGTTGTTTATGGATTCATCCCAGAACAAACAGCAAAACTTTTTATATTGCTGAACAGGTGTCCCATCATCCACCAATATCTGCCTTTTAT
GTTAGTAATCGAAAAGATGGATTTTGCCTTAGCGGTAGTATCCTGGCTAAGTCTAAGTTTTATGGAAACTCATTATCTGCAATATTAGAGGGAGAAGCAC
GGTTAACTTTCTTGAATAGAGGTGAAGATTATGTAATGACAATGCCATACGCTCATTGTAAAGGAATTCTTTATGGTACAATGACACTGGAGCTTGGTGG
AACAGTCAATATTACATGTCAAAAAACTGGATACAGTGCAATACTTGAATTTAAACTAAAGCCATTCCTAGGGAGTAGTGACTGTGTTAATCAAATATCA
GGGAAACTTAAACTGGGAAAAGAAGTCCTAGCTACTTTGGAAGGTCATTGGGATAGTGAAGTTTTTATTACTGATAAAAAGACTGATAATTCAGAGGTTT
TCTGGAATCCAACACCTGACATTAAGCAATGGAGATTAATAAGGCACACTGTAAAATTTGAAGAACAGGGAGATTTTGAATCAGAGAAACTCTGGCAACG
GGTAACTCGAGCCATAAATGCCAAAGACCAAACTGAAGCTACCCAAGAGAAGTATGTTTTGGAAGAAGCTCAAAGACAAGCTGCCAGGGATCGGAAAACA
AAAAATGAAGAGTGGTCTTGCAAATTATTTGAACTTGATCCACTCACAGGAGAATGGCATTACAAGTTTGCAGATACCCGACCATGGGACCCACTTAATG
ATATGATACAGTTTGAAAAAGATGGTGTTATTCAGACCAAAGTGAAACATCGTACTCCAATGGTTAGCGTCCCCAAAATGAAACATAAGCCAACCAGGCA
ACAGAAGAAAGTAGCAAAAGGCTATTCCTCCCCAGAACCTGACATTCAAGACTCCTCTGGAAGTGAAGCTCAATCAGTAAAACCAAGTACAAGAAGAAAG
AAAGGAATAGAACTGGGAGACATTCAGAGTTCCATCGAATCTATAAAACAAACACAGGAAGAAATTAAAAGAAATATTATGGCTCTTCGAAATCATTTAG
TTTCAAGCACACCGGCCACGGATTATTTTCTGCAACAAAAAGACTACTTCATCATTTTCCTCCTGATTTTGCTTCAAGTCATAATAAACTTCATGTTCAA
GTAGAAGTTCTCTACCATTGAATCAGTGAACTAGAAAGATCTGATTTGGCCTGGGACCAGTGTTCAAGTTGGTTTGGTCTTTATTAAAAATCACAATATT
CCGAAAACAAAAAAACCTAGGAGATAAATGTAGAGGTATTGACTTTTCGTATCTTTTATCTTCACACTGAAACAAGAGCTATCCTATTTGATTATTAAAG
TGAGCTATGTGTTAAGTGCCAGGACATTTCTAGCTTTTGTGAGAATGTGTCTACATATGAGTATAATAAACCCACATGTATACACAATTGTCTCTTATGT
ACTCCTACCTGACAGTAGTCTTTGTATTCTATAGTATGTTCTGAGATATAATGTTAACATTGTTCATAACAAAAAATGCTATCAATCTTATAAATATATG
TAATCTATTTTCTTCATAAAACAGGCACAAAAGTTTTATCAGTAAGGAATTACAGATTGAGAAATGATGGAATAATAGACATAATTAATTCAATACACTA
CTGTTAAAATCATTTGCAAAGCACTCAGCTCAATTATCTTCTTAGAAAGAAAGAAAAAGTATGAATGGTCAAAATGAATACATCGAGAGAGATAAATGGC
AAATTGCTTTTTTAAAAGTTTACATAAGTTTTTTTTAACCCCTAGAATTTAATATTTGTAGATGCAGGTAAATATATATACTTACGTGTATATCAGTATA
AAAACACTGGTGTGCAATTAATTGGATTGATTATAATACCACCTTAAGCACTTGCTGAAAAAAGTGTGGTCAAAATTGATTGCTGTCCTTTTGTCTTATT
TTTGTTTTTCTTAAGTCAGCTGGTTCATAACATAGGCCAAATTCTAGAGATGTTTATAGAGCATTTGAAGTGCTGATAATTTATGTTTTTTCATTATGAA
AACTTATTTTAGCTTTAGACTCCAGTGTGTTCAGTGAATAAGTAGAATATAAAAAAATATAACCAGTATTTTACTTCAAAAGCCAAAAAGAGGCAATAAG
AAAAGACACTTTGTGGTGGCCTTTATGTGTGCATTAAAATTGGTTTCTGTAAAACGTGTAATAAGTTGAGTATCTACGAAGAGTATCAAGTTCTGAAGTT
TAATTTTTTTATTATCCTCCTCTCTTCTTAGTAACTTCTTTCTGTGGCAAAACCACAATTCTTTAAGATTCCTATTGTTCAGGCTAAGGCAAATTTTTTT
GTTTGTTTCTTCAGTTTAATATTTTGATTTTGTGTTTTTACGTAAATATTTATATTCCTTGAAAGCAATTTTTGCCAAGGTAGTTCAGTTTAGGAATATG
TTGTTCTAAAATATGTCTTAGAATCCTGAAAGCATAGATTTTGAAATGTTTTTTTAATGAAAATGAAGGTCAGAGAGAATAATTGCCCTGACCACATTTG
CCTTTCAGTAGGAGGAGGCTGTGAAATAGTAAAATTATAATCGTTTATGCCATGATAAATACAAGATTGGTAAATAAATACATTGATTGGTAAATTATGA
GAATCAAAATGATAAAAAGAGCCTGCTTTTTTCCCTAACCAATATAGCTATCTTAAGTATCCTTAGGTTTCTGTGAAGAACCATTTCCCATGTTTTCTTG
GCAAAATAATGCTGTATTCCATATGTACATGTGAAATGATGTTTTAAATTGATAAAAGCTTAAATAAGATCTACCTATACCCAGTATTTTCATGATATTA
GAACAAATGGGTTTTTGGTTATATTTTATATTTGTCAATATAATTTTTGTATTCACATTCTGTTACACTCTGCCTATTCATTGATATATGATATTCTGTA
AATATTGTACAATTTGATCTTTTTTATGGTTTAAATTAGTTAATTACATACAAATTGATTGGCTTATCACAAAAATCATTTCATCAGTAAACCTTGTTAA
CATTTTGTACTGGTGACCCACCTCTTAGGACTTTGGTCTTATCCACGTGTATGTTGTTTTCATTTGGTCCAAATAATATTTTATTTGTATGGGTATCTTC
TAAGACTAAATAGGTAGTTGTGTTCTTTATTTTTAAAATTTCTTTTTAGAGCAAATGTTATGGGTTCTTACCCAAAGAGTCAAAAACTATTTCTTAAGAA
AGAGCAGAGTTATTCATGACTGTTCTTTATACACTAAAAGCATGCATCTAATCTAATAGTCCTCTTATTATGCTTTTAGTTGTATGAGTCTCTTTCTATG
AACTGAACACAAAACTCAGGAATTGGTGGCTTAATTTTAGATCAGTGCTTGTACTAGGCTTAGTTATATGAATCTTTATAACACATAATTACTAACTTTG
TAGCCATATATGTAATTGACTTTGAATGTTATTTACCTGAAATTAATCTTCCTTCACACATGGACCGTAAACGGTTCCCAGTTGTCTGAGAGCCTCATGA
GGGTTTCTAGGATTTATGACCTTATGACCAGTTTTTTTCATTTACCAAGATTTTATTTTCCTACATGAAAATTTAATTGAGTAATAATTATTCACATGTG
CATTTTCTTTTTAGCTGTTAAATGTACTATGCCATCATCCACCATTTAGTAAAATGTAGCTGGCCCAGGACATGTAAAAAAAAAAAAAAAACAACAACAA
TAAATAGGGCATGTGAAATGTTAAGTTACAGCAATAGATATTTTATTTGTATTTCATGTTAGTACTTTTTTGTTTTATATCACTTATAAAGGTACAGTGT
ACTCTTTGTCACAGCTCAGTTGGTAACCGCATTCCATTGAAAAGTTGGCCTTGTAAAATACAACTCTCATTTAATATTCATGCTTTTGTGCCTTTAAGAA
AATATTTTTTGTCATTTTTTGTGTTACAGAACTATAATGTGATTCAAGGTGTTTATAGGCTTGTCATAAAAGGGTCATTTCTGTGTGTTACTTTCTTTTT
ATATAGCTATAGTATATTTAAACAATAATACTATCTTTTATAGGGGTTTGTCTATTTACCTATTCTTTACTCAGACATTGATGTAGACTTGTCAGATTAT
TCTGAGTATTGTTAACAGTGCCTTTTCGATGGAATCACACTTTTTGGCTGTCACCTTGTGCCATATACACACAAAATTTTGTGGAAGGCAGTTTTAACTT
TCTGAAGAATATCTGTCAAAATTTAAGAAAACAAATGTATAAAATTCCATTTTTTCCAGTGTTTAGCATTTCTAGTAAGCAGTGAGGTTGTTTGACATAC
AGTGATGATGGCATTATTGATAAGCCATACATGAGACTGCAGATTATATTGAATCATATTAAATGTACAGAAATAAAATATTAGATTTATATCAAATTTT
CCAATTTGAACCAGTGGGGAAAATCCCACAGAAATCAGTAAGTTTACATTTCAATTTCTATCTTATTTGACTAAGTGGAAAGAGATTCTTTAAAATGTAT
AACCTGCCATTATGTAATTTGGTTTCATTTTATTCTACCTGTTGTGTGAGTTTAGTATATTTAATTTACTTTTTGTTACTCTTTACATACTGTTTATTTT
TGTTAGTTTTTAATTGAAGATGGACTGTTGAAATTGTATAGGACCAGTGTCTTATTAATATGATTAATATATTTAGAAGAGCCACGTGAAACCCATGACA
AAATGAATGTGAATATTCTTTCTAAAAATTTAGAAAATGTTATCTTTTTGCATTTATTATGTAAAACTGTTTTACAGTATCAAAATTTTTCACTTAAAGA
AAAAAAATGCCATGAAACATTTGAACTGATGAGCCACAGAACTTCAGTTGAAATTTTTTTCACTTTTTAGCATGCTAAATATACATCTGAGTTTAAATGT
TCTGTTTAATGGCCATTCATAAATTCAAGCACTACCACTGGTCAGTTTTGTGTGATAGAATAAAAATATGTTACCTGCAGTGTAAGTACAGCACACTGTC
AAATTCTTTTCCTTAAGGTGCACAGTAAATGTACAGATAGTTATAGGCCACTGTTTTGTAATGTAGTACATTTCTAATCTATTATTCCTAACCTATTATA
ACTGTTTGCAGAAAGAAAAGAATTTTTCTAATAATCTGTAAAATTATGCTAACTTCTACAAGTAGGCTTCTAAATAAAATTTTTAAAAAGAGCAAA
- refseq_OSBPL8.F1 (forward primer)
- refseq_OSBPL8.R1 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
H*NVKDLRGSGCPERRRRGG*QH*AATRSWPGGGCSVSFGRRSSRCR*QAD*GKVGVRPGWWTSGPK
VPAPLGG*AGSASAAAGQRPSSRLAPQLPPTTA
AERSWGLTRRLRGLGPRRRGDLGGTGSLRPASL
GAPHGICRFTEWLHINGKRSINLSSFIMEGGLAD
GEPDRTSQTVTNLSF*HQER*VSAKEKKLIQRQ
PKICISHLLVQQVLIARVLKEGRKIFLKIKMNL
HFLCQRASLNLNFIMAQRRTVQLQANSQKKNLLR
YKRKITEKKRKEPQRSCSVQSQILLLLLWLIG*
RFVVL*RAGPSYGVC*NLGCY*SIKPKKMVSG*
EQFF*MPVKSLNVHQKRMAFVSNFSILWSNLFGQ
*RVQKVKRLDPLLNPYLAVI*SSELLQSQMEGA
GWMLWSWL*NVLVFLNVQ*SEKERNMT*AFHQI
AHM*LSMAYYVLTISTVVITSS*MIVKLNDNILR
TKICILINLIKKMIKNMMSLIMR*WGKVKKVTQ
IHQKDKMTHISNLSLLSL*RRLPTLNRAMKNLE
RQVRLLKQKLYLKKTKALSGHY*NKSVLAWTYPR
WFCLHLFWNPVLSWINFQITTIMQISYLRQLLK
KILISV*RK**NGICQDSIKSQRD*RNLIILYL
ARLSVVYGFIPEQTAKLFILLNRCPIIHQYLPFM
LVIEKMDFALAVVSWLSLSFMETHYLQY*REKH
G*LS*IEVKIM**QCHTLIVKEFFMVQ*HWSLV
EQSILHVKKLDTVQYLNLN*SHS*GVVTVLIKYQ
GNLNWEKKS*LLWKVIGIVKFLLLIKRLIIQRF
SGIQHLTLSNGD**GTL*NLKNREILNQRNSGN
G*LEP*MPKTKLKLPKRSMFWKKLKDKLPGIGKQ
KMKSGLANYLNLIHSQENGITSLQIPDHGTHLM
I*YSLKKMVLFRPK*NIVLQWLASPK*NISQPG
NRRK*QKAIPPQNLTFKTPLEVKLNQ*NQVQEER
KE*NWETFRVPSNL*NKHRKKLKEILWLFEII*
FQAHRPRIIFCNKKTTSSFSS*FCFKS**TSCS
SRSSLPLNQ*TRKI*FGLGPVFKLVWSLLKITIF
RKQKNLGDKCRGIDFSYLLSSH*NKSYPI*LLK
*AMC*VPGHF*LL*ECVYI*V**THMYTQLSLM
YSYLTVVFVFYSMF*DIMLTLFITKNAINLINIC
NLFSS*NRHKSFISKELQIEK*WNNRHN*FNTL
LLKSFAKHSAQLSS*KERKSMNGQNEYIERDKW
QIAFLKVYISFF*PLEFNICRCR*IYILTCISV*
KHWCAINWIDYNTTLSTC*KKCGQN*LLSFCLI
FVFLKSAGS*HRPNSRDVYRAFEVLIIYVFSL*
KLILALDSSVFSE*VEYKKI*PVFYFKSQKEAIR
KDTLWWPLCVH*NWFL*NV**VEYLRRVSSSEV
*FFYYPPLFLVTSFCGKTTIL*DSYCSG*GKFF
CLFLQFNILILCFYVNIYIP*KQFLPR*FSLGIC
CSKICLRILKA*ILKCFFNENEGQRE*LP*PHL
PFSRRRL*NSKIIIVYAMINTRLVNKYIDW*IM
RIKMIKRACFFP*PI*LS*VSLGFCEEPFPMFSW
QNNAVFHMYM*NDVLN**KLK*DLPIPSIFMIL
EQMGFWLYFIFVNIIFVFTFCYTLPIH*YMIFC
KYCTI*SFLWFKLVNYIQIDWLITKIISSVNLVN
ILYW*PTS*DFGLIHVYVVFIWSK*YFICMGIF
*D*IGSCVLYF*NFFLEQMLWVLTQRVKNYFLR
KSRVIHDCSLYTKSMHLI**SSYYAFSCMSLFL*
TEHKTQELVA*F*ISACTRLSYMNLYNT*LLTL
*PYM*LTLNVIYLKLIFLHTWTVNGSQLSESLM
RVSRIYDLMTSFFHLPRFYFPT*KFN*VIIIHMC
IFFLAVKCTMPSSTI**NVAGPGHVKKKKKQQQ
*IGHVKC*VTAIDILFVFHVSTFLFYITYKGTV
YSLSQLSW*PHSIEKLAL*NTTLI*YSCFCAFKK
IFFVIFCVTEL*CDSRCL*ACHKRVISVCYFLF
I*L*YI*TIILSFIGVCLFTYSLLRH*CRLVRL
F*VLLTVPFRWNHTFWLSPCAIYTQNFVEGSFNF
LKNICQNLRKQMYKIPFFPVFSISSKQ*GCLTY
SDDGIIDKPYMRLQIILNHIKCTEIKY*IYIKF
SNLNQWGKSHRNQ*VYISISILFD*VERDSLKCI
TCHYVIWFHFILPVV*V*YI*FTFCYSLHTVYF
C*FLIEDGLLKLYRTSVLLI*LIYLEEPRETHD
KMNVNILSKNLENVIFLHLLCKTVLQYQNFSLKE
KKCHETFELMSHRTSVEIFFTF*HAKYTSEFKC
SV*WPFINSSTTTGQFCVIE*KYVTCSVSTAHC
QILFLKVHSKCTDSYRPLFCNVVHF*SIIPNLL*
LFAERKEFF**SVKLC*LLQVGF*IKFLKRA
Frame 1
TRM*RIFAVLGAQKGGDAADDNIRPRRAPGQAAAVVLALDAAVAAAGSKPTEGRWGSARAGGPRGR
KFPPRSGAEPAVPPRPLGSALRPGSRPSCRRRQR
PREVGV*LDAYGASDPGAAATSEEPAPCVPPPW
ELRTGFADLQNGCTLMEREA*TYLLSLWREVWQ
MENLIELRKQ*RISASDTRKDESAPRKRSLSNAN
QRFASAIS*SSKSS*PGF*KREGRYFSK*R*IF
TFYVKEQV*I*TL*WLREGQFNFKQTHKKRIS*
GTKEKLPRRKEKSHKGAAQYNHRSFCYCYG*LVK
DSWYSKELDQVMVCVETWGATDL*NPKKWSVGR
NSSSECL*NH*TSIKKGWLLFQTFPSFGAIYLG
SEGSKR*SGWIHYSTLT*QLFDHPSYFRVRWKVL
DGCFGVGFEMF*SS*TYNDQRRKGT*PERFIR*
HTCDFLWLTTC*QSPQW**LPVK***N*TTTF*
GPRYVF**I**RK*SRT**V***GDGEK*RK*HR
YIRKTR*LIYRT*AC*AFKGDYLH*TEP*RTWR
GR*GFSNRNCI*RKQKPYLDTIETSPSWHGPIQ
GGSAYIYFGTPFFPG*TFRLLLSCRFPI*GSS*R
KSLFPFEESSEMVFVRIL*KAKGTEETL*SYTW
RDFPLFMDSSQNKQQNFLYC*TGVPSSTNICLL
C**SKRWILP*R*YPG*V*VLWKLIICNIRGRST
VNFLE*R*RLCNDNAIRSL*RNSLWYNDTGAWW
NSQYYMSKNWIQCNT*I*TKAIPRE**LC*SNI
RET*TGKRSPSYFGRSLG**SFYY**KD**FRGF
LESNT*H*AMEINKAHCKI*RTGRF*IRETLAT
GNSSHKCQRPN*SYPREVCFGRSSKTSCQGSEN
KK*RVVLQII*T*STHRRMALQVCRYPTMGPT**
YDTV*KRWCYSDQSETSYSNG*RPQNET*ANQA
TEESSKRLFLPRT*HSRLLWK*SSISKTKYKKK
ERNRTGRHSEFHRIYKTNTGRN*KKYYGSSKSFS
FKHTGHGLFSATKRLLHHFPPDFASSHNKLHVQ
VEVLYH*ISELERSDLAWDQCSSWFGLY*KSQY
SENKKT*EINVEVLTFRIFYLHTETRAILFDY*S
ELCVKCQDISSFCENVSTYEYNKPTCIHNCLLC
TPT*Q*SLYSIVCSEI*C*HCS*QKMLSIL*IY
VIYFLHKTGTKVLSVRNYRLRNDGIIDIINSIHY
C*NHLQSTQLNYLLRKKEKV*MVKMNTSREING
KLLF*KFT*VFFNP*NLIFVDAGKYIYLRVYQY
KNTGVQLIGLIIIPP*ALAEKSVVKIDCCPFVLF
LFFLSQLVHNIGQILEMFIEHLKC**FMFFHYE
NLF*L*TPVCSVNK*NIKKYNQYFTSKAKKRQ*
EKTLCGGLYVCIKIGFCKTCNKLSIYEEYQVLKF
NFFIILLSS**LLSVAKPQFFKIPIVQAKANFF
VCFFSLIF*FCVFT*IFIFLESNFCQGSSV*EY
VVLKYVLES*KHRF*NVFLMKMKVRENNCPDHIC
LSVGGGCEIVKL*SFMP**IQDW*INTLIGKL*
ESK**KEPAFFPNQYSYLKYP*VSVKNHFPCFL
GKIMLYSICTCEMMF*IDKSLNKIYLYPVFS*Y*
NKWVFGYILYLSI*FLYSHSVTLCLFIDI*YSV
NIVQFDLFYGLN*LITYKLIGLSQKSFHQ*TLL
TFCTGDPPLRTLVLSTCMLFSFGPNNILFVWVSS
KTK*VVVFFIFKISF*SKCYGFLPKESKTIS*E
RAELFMTVLYTLKACI*SNSPLIMLLVV*VSFY
ELNTKLRNWWLNFRSVLVLGLVI*IFITHNY*LC
SHICN*L*MLFT*N*SSFTHGP*TVPSCLRAS*
GFLGFMTL*PVFFIYQDFIFLHENLIE**LFTC
AFSF*LLNVLCHHPPFSKM*LAQDM*KKKKNNNN
K*GM*NVKLQQ*IFYLYFMLVLFCFISLIKVQC
TLCHSSVGNRIPLKSWPCKIQLSFNIHAFVPLR
KYFLSFFVLQNYNVIQGVYRLVIKGSFLCVTFFL
YSYSIFKQ*YYLL*GFVYLPILYSDIDVDLSDY
SEYC*QCLFDGITLFGCHLVPYTHKILWKAVLT
F*RISVKI*ENKCIKFHFFQCLAFLVSSEVV*HT
VMMALLISHT*DCRLY*IILNVQK*NIRFISNF
PI*TSGENPTEISKFTFQFLSYLTKWKEIL*NV
*PAIM*FGFILFYLLCEFSIFNLLFVTLYILFIF
VSF*LKMDC*NCIGPVSY*YD*YI*KSHVKPMT
K*M*IFFLKI*KMLSFCIYYVKLFYSIKIFHLK
KKNAMKHLN**ATELQLKFFSLFSMLNIHLSLNV
LFNGHS*IQALPLVSFV**NKNMLPAV*VQHTV
KFFSLRCTVNVQIVIGHCFVM*YISNLLFLTYY
NCLQKEKNFSNNL*NYANFYK*ASK*NF*KEQ
Frame 2
LECEGSSRFWVPRKAATRRMTTLGRDALLARRRL*C*LWTPQ*PLPVASRLREGGGPPGLVDLGAE
SSRPARGLSRQCLRGRWAAPFVQARAPAAADDS
GREKLGSD*TLTGPRTPAPRRPRRNRLLASRLPG
SSARDLQIYRMAAH*WKEKHKPIFFHYGGRFGR
WRT*SNFANSDESQLLTPGKMSQRQGKEAYPTP
TKDLHQPSLSPASPHSQGFERGKEDISQNKDESS
LSMSKSKSESKLYNGSEKDSSTSSKLTKKESLK
VQKKNYREEKKRATKELLSTITDPSVIVMADWL
KIRGTLKSWTKLWCVLKPGVLLIYKTQKNGQWVG
TVLLNACEIIERPSKKDGFCFKLFHPLEQSIWA
VKGPKGEAVGSITQPLPSSYLIIRATSESDGRC
WMDALELALKCSSLLKRTMIREGKEHDLSVSSDS
THVTFYGLLRANNLHSGDNFQLNDSEIERQHFK
DQDMYSDKSDKENDQEHDESDNEVMGKSEESDT
DTSERQDDSYIEPEPVEPLKETTYTEQSHEELGE
AGEASQTETVSEENKSLIWTLLKQVRPGMDLSK
VVLPTFILEPRSFLDKLSDYYYHADFLSEAALE
ENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILG
ETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFY
VSNRKDGFCLSGSILAKSKFYGNSLSAILEGEA
RLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGG
TVNITCQKTGYSAILEFKLKPFLGSSDCVNQIS
GKLKLGKEVLATLEGHWDSEVFITDKKTDNSEV
FWNPTPDIKQWRLIRHTVKFEEQGDFESEKLWQR
VTRAINAKDQTEATQEKYVLEEAQRQAARDRKT
KNEEWSCKLFELDPLTGEWHYKFADTRPWDPLN
DMIQFEKDGVIQTKVKHRTPMVSVPKMKHKPTRQ
QKKVAKGYSSPEPDIQDSSGSEAQSVKPSTRRK
KGIELGDIQSSIESIKQTQEEIKRNIMALRNHL
VSSTPATDYFLQQKDYFIIFLLILLQVIINFMFK
*KFSTIESVN*KDLIWPGTSVQVGLVFIKNHNI
PKTKKPRR*M*RY*LFVSFIFTLKQELSYLIIK
VSYVLSARTFLAFVRMCLHMSIINPHVYTIVSYV
LLPDSSLCIL*YVLRYNVNIVHNKKCYQSYKYM
*SIFFIKQAQKFYQ*GITD*EMME**T*LIQYT
TVKIICKALSSIIFLERKKKYEWSK*IHRER*MA
NCFFKSLHKFFLTPRI*YL*MQVNIYTYVYISI
KTLVCN*LD*L*YHLKHLLKKVWSKLIAVLLSY
FCFS*VSWFIT*AKF*RCL*SI*SADNLCFFIMK
TYFSFRLQCVQ*ISRI*KNITSILLQKPKRGNK
KRHFVVAFMCALKLVSVKRVIS*VSTKSIKF*S
LIFLLSSSLLSNFFLWQNHNSLRFLLFRLRQIFL
FVSSV*YFDFVFLRKYLYSLKAIFAKVVQFRNM
LF*NMS*NPESIDFEMFF**K*RSERIIALTTF
AFQ*EEAVK**NYNRLCHDKYKIGK*IH*LVNYE
NQNDKKSLLFSLTNIAILSILRFL*RTISHVFL
AK*CCIPYVHVK*CFKLIKA*IRSTYTQYFHDI
RTNGFLVIFYICQYNFCIHILLHSAYSLIYDIL*
ILYNLIFFMV*IS*LHTN*LAYHKNHFISKPC*
HFVLVTHLLGLWSYPRVCCFHLVQIIFYLYGYL
LRLNR*LCSLFLKFLFRANVMGSYPKSQKLFLKK
EQSYS*LFFIH*KHASNLIVLLLCF*LYESLSM
N*TQNSGIGGLILDQCLY*A*LYESL*HIITNF
VAIYVIDFECYLPEINLPSHMDRKRFPVV*EPHE
GF*DL*PYDQFFSFTKILFSYMKI*LSNNYSHV
HFLFSC*MYYAIIHHLVKCSWPRTCKKKKKTTT
INRACEMLSYSNRYFICISC*YFFVLYHL*RYSV
LFVTAQLVTAFH*KVGLVKYNSHLIFMLLCL*E
NIFCHFLCYRTIM*FKVFIGLS*KGHFCVLLSF
YIAIVYLNNNTIFYRGLSIYLFFTQTLM*TCQII
LSIVNSAFSMESHFLAVTLCHIHTKFCGRQF*L
SEEYLSKFKKTNV*NSIFSSV*HF**AVRLFDI
Q**WHY**AIHETADYIESY*MYRNKILDLYQIF
QFEPVGKIPQKSVSLHFNFYLI*LSGKRFFKMY
NLPLCNLVSFYSTCCVSLVYLIYFLLLFTYCLF
LLVFN*RWTVEIV*DQCLINMINIFRRAT*NP*Q
NECEYSF*KFRKCYLFAFIM*NCFTVSKFFT*R
KKMP*NI*TDEPQNFS*NFFHFLAC*IYI*V*M
FCLMAIHKFKHYHWSVLCDRIKICYLQCKYSTLS
NSFP*GAQ*MYR*L*ATVL*CSTFLIYYS*PII
TVCRKKRIFLIICKIMLTSTSRLLNKIFKKSK
Sequence NM_020841
CACTAGAATGTGAAGGATCTTCGCGGTTCTGGGTGCCCAGAAAGGCGGCGACGCGGCGGATGACAACATTAGGCCGCGACGCGCTCCTGGCCAGGCGGCGGCTGTAGTGTTAGCTTTGGACGCCGCAGTAGCCGCTGCCGGTAGCAAGCCGACTGAGGGAAGGTGGGGGTCCGCCCGGGCTGGTGGACCTCGGGGCCGAA
AGTTCCCGCCCCGCTCGGGGGCTGAGCCGGCAGTGCCTCCGCGGCCGCTGGGCAGCGCCCTTCGTCCAGGCTCGCGCCCCAGCTGCCGCCGACGACAGCG
GCCGAGAGAAGTTGGGGTCTGACTAGACGCTTACGGGGCCTCGGACCCCGGCGCCGCGGCGACCTCGGAGGAACCGGCTCCTTGCGTCCCGCCTCCCTGG
GAGCTCCGCACGGGATTTGCAGATTTACAGAATGGCTGCACATTAATGGAAAGAGAAGCATAAACCTATCTTCTTTCATTATGGAGGGAGGTTTGGCAGA
TGGAGAACCTGATCGAACTTCGCTTCTTGGTGATAGCAAAGATGTCCTTGGGCCATCAACTGTTGTAGCAAACAGTGACGAATCTCAGCTTCTGACACCA
GGAAAGATGAGTCAGCGCCAAGGAAAAGAAGCTTATCCAACGCCAACCAAAGATTTGCATCAGCCATCTCTTAGTCCAGCAAGTCCTCATAGCCAGGGTT
TTGAAAGAGGGAAGGAAGATATTTCTCAAAATAAAGATGAATCTTCACTTTCTATGTCAAAGAGCAAGTCTGAATCTAAACTTTATAATGGCTCAGAGAA
GGACAGTTCAACTTCAAGCAAACTCACAAAAAAAGAATCTCTTAAGGTACAAAAGAAAAATTACCGAGAAGAAAAGAAAAGAGCCACAAAGGAGCTGCTC
AGTACAATCACAGATCCTTCTGTTATTGTTATGGCTGATTGGTTAAAGATTCGTGGTACTCTAAAGAGCTGGACCAAGTTATGGTGTGTGTTGAAACCTG
GGGTGCTACTGATCTATAAAACCCAAAAAAATGGTCAGTGGGTAGGAACAGTTCTTCTGAATGCCTGTGAAATCATTGAACGTCCATCAAAAAAGGATGG
CTTTTGTTTCAAACTTTTCCATCCTTTGGAGCAATCTATTTGGGCAGTGAAGGGTCCAAAAGGTGAAGCGGTTGGATCCATTACTCAACCCTTACCTAGC
AGTTATTTGATCATCCGAGCTACTTCAGAGTCAGATGGAAGGTGCTGGATGGATGCTTTGGAGTTGGCTTTGAAATGTTCTAGTCTTCTTAAACGTACAA
TGATCAGAGAAGGAAAGGAACATGACCTGAGCGTTTCATCAGATAGCACACATGTGACTTTCTATGGCTTACTACGTGCTAACAATCTCCACAGTGGTGA
TAACTTCCAGTTAAATGATAGTGAAATTGAACGACAACATTTTAAGGACCAAGATATGTATTCTGATAAATCTGATAAAGAAAATGATCAAGAACATGAT
GAGTCTGATAATGAGGTGATGGGGAAAAGTGAAGAAAGTGACACAGATACATCAGAAAGACAAGATGACTCATATATCGAACCTGAGCCTGTTGAGCCTT
TAAAGGAGACTACCTACACTGAACAGAGCCATGAAGAACTTGGAGAGGCAGGTGAGGCTTCTCAAACAGAAACTGTATCTGAAGAAAACAAAAGCCTTAT
CTGGACACTATTGAAACAAGTCCGTCCTGGCATGGACCTATCCAAGGTGGTTCTGCCTACATTTATTTTGGAACCCCGTTCTTTCCTGGATAAACTTTCA
GATTACTACTATCATGCAGATTTCCTATCTGAGGCAGCTCTTGAAGAAAATCCTTATTTCCGTTTGAAGAAAGTAGTGAAATGGTATTTGTCAGGATTCT
ATAAAAAGCCAAAGGGACTGAAGAAACCTTATAATCCTATACTTGGCGAGACTTTCCGTTGTTTATGGATTCATCCCAGAACAAACAGCAAAACTTTTTA
TATTGCTGAACAGGTGTCCCATCATCCACCAATATCTGCCTTTTATGTTAGTAATCGAAAAGATGGATTTTGCCTTAGCGGTAGTATCCTGGCTAAGTCT
AAGTTTTATGGAAACTCATTATCTGCAATATTAGAGGGAGAAGCACGGTTAACTTTCTTGAATAGAGGTGAAGATTATGTAATGACAATGCCATACGCTC
ATTGTAAAGGAATTCTTTATGGTACAATGACACTGGAGCTTGGTGGAACAGTCAATATTACATGTCAAAAAACTGGATACAGTGCAATACTTGAATTTAA
ACTAAAGCCATTCCTAGGGAGTAGTGACTGTGTTAATCAAATATCAGGGAAACTTAAACTGGGAAAAGAAGTCCTAGCTACTTTGGAAGGTCATTGGGAT
AGTGAAGTTTTTATTACTGATAAAAAGACTGATAATTCAGAGGTTTTCTGGAATCCAACACCTGACATTAAGCAATGGAGATTAATAAGGCACACTGTAA
AATTTGAAGAACAGGGAGATTTTGAATCAGAGAAACTCTGGCAACGGGTAACTCGAGCCATAAATGCCAAAGACCAAACTGAAGCTACCCAAGAGAAGTA
TGTTTTGGAAGAAGCTCAAAGACAAGCTGCCAGGGATCGGAAAACAAAAAATGAAGAGTGGTCTTGCAAATTATTTGAACTTGATCCACTCACAGGAGAA
TGGCATTACAAGTTTGCAGATACCCGACCATGGGACCCACTTAATGATATGATACAGTTTGAAAAAGATGGTGTTATTCAGACCAAAGTGAAACATCGTA
CTCCAATGGTTAGCGTCCCCAAAATGAAACATAAGCCAACCAGGCAACAGAAGAAAGTAGCAAAAGGCTATTCCTCCCCAGAACCTGACATTCAAGACTC
CTCTGGAAGTGAAGCTCAATCAGTAAAACCAAGTACAAGAAGAAAGAAAGGAATAGAACTGGGAGACATTCAGAGTTCCATCGAATCTATAAAACAAACA
CAGGAAGAAATTAAAAGAAATATTATGGCTCTTCGAAATCATTTAGTTTCAAGCACACCGGCCACGGATTATTTTCTGCAACAAAAAGACTACTTCATCA
TTTTCCTCCTGATTTTGCTTCAAGTCATAATAAACTTCATGTTCAAGTAGAAGTTCTCTACCATTGAATCAGTGAACTAGAAAGATCTGATTTGGCCTGG
GACCAGTGTTCAAGTTGGTTTGGTCTTTATTAAAAATCACAATATTCCGAAAACAAAAAAACCTAGGAGATAAATGTAGAGGTATTGACTTTTCGTATCT
TTTATCTTCACACTGAAACAAGAGCTATCCTATTTGATTATTAAAGTGAGCTATGTGTTAAGTGCCAGGACATTTCTAGCTTTTGTGAGAATGTGTCTAC
ATATGAGTATAATAAACCCACATGTATACACAATTGTCTCTTATGTACTCCTACCTGACAGTAGTCTTTGTATTCTATAGTATGTTCTGAGATATAATGT
TAACATTGTTCATAACAAAAAATGCTATCAATCTTATAAATATATGTAATCTATTTTCTTCATAAAACAGGCACAAAAGTTTTATCAGTAAGGAATTACA
GATTGAGAAATGATGGAATAATAGACATAATTAATTCAATACACTACTGTTAAAATCATTTGCAAAGCACTCAGCTCAATTATCTTCTTAGAAAGAAAGA
AAAAGTATGAATGGTCAAAATGAATACATCGAGAGAGATAAATGGCAAATTGCTTTTTTAAAAGTTTACATAAGTTTTTTTTAACCCCTAGAATTTAATA
TTTGTAGATGCAGGTAAATATATATACTTACGTGTATATCAGTATAAAAACACTGGTGTGCAATTAATTGGATTGATTATAATACCACCTTAAGCACTTG
CTGAAAAAAGTGTGGTCAAAATTGATTGCTGTCCTTTTGTCTTATTTTTGTTTTTCTTAAGTCAGCTGGTTCATAACATAGGCCAAATTCTAGAGATGTT
TATAGAGCATTTGAAGTGCTGATAATTTATGTTTTTTCATTATGAAAACTTATTTTAGCTTTAGACTCCAGTGTGTTCAGTGAATAAGTAGAATATAAAA
AAATATAACCAGTATTTTACTTCAAAAGCCAAAAAGAGGCAATAAGAAAAGACACTTTGTGGTGGCCTTTATGTGTGCATTAAAATTGGTTTCTGTAAAA
CGTGTAATAAGTTGAGTATCTACGAAGAGTATCAAGTTCTGAAGTTTAATTTTTTTATTATCCTCCTCTCTTCTTAGTAACTTCTTTCTGTGGCAAAACC
ACAATTCTTTAAGATTCCTATTGTTCAGGCTAAGGCAAATTTTTTTGTTTGTTTCTTCAGTTTAATATTTTGATTTTGTGTTTTTACGTAAATATTTATA
TTCCTTGAAAGCAATTTTTGCCAAGGTAGTTCAGTTTAGGAATATGTTGTTCTAAAATATGTCTTAGAATCCTGAAAGCATAGATTTTGAAATGTTTTTT
TAATGAAAATGAAGGTCAGAGAGAATAATTGCCCTGACCACATTTGCCTTTCAGTAGGAGGAGGCTGTGAAATAGTAAAATTATAATCGTTTATGCCATG
ATAAATACAAGATTGGTAAATAAATACATTGATTGGTAAATTATGAGAATCAAAATGATAAAAAGAGCCTGCTTTTTTCCCTAACCAATATAGCTATCTT
AAGTATCCTTAGGTTTCTGTGAAGAACCATTTCCCATGTTTTCTTGGCAAAATAATGCTGTATTCCATATGTACATGTGAAATGATGTTTTAAATTGATA
AAAGCTTAAATAAGATCTACCTATACCCAGTATTTTCATGATATTAGAACAAATGGGTTTTTGGTTATATTTTATATTTGTCAATATAATTTTTGTATTC
ACATTCTGTTACACTCTGCCTATTCATTGATATATGATATTCTGTAAATATTGTACAATTTGATCTTTTTTATGGTTTAAATTAGTTAATTACATACAAA
TTGATTGGCTTATCACAAAAATCATTTCATCAGTAAACCTTGTTAACATTTTGTACTGGTGACCCACCTCTTAGGACTTTGGTCTTATCCACGTGTATGT
TGTTTTCATTTGGTCCAAATAATATTTTATTTGTATGGGTATCTTCTAAGACTAAATAGGTAGTTGTGTTCTTTATTTTTAAAATTTCTTTTTAGAGCAA
ATGTTATGGGTTCTTACCCAAAGAGTCAAAAACTATTTCTTAAGAAAGAGCAGAGTTATTCATGACTGTTCTTTATACACTAAAAGCATGCATCTAATCT
AATAGTCCTCTTATTATGCTTTTAGTTGTATGAGTCTCTTTCTATGAACTGAACACAAAACTCAGGAATTGGTGGCTTAATTTTAGATCAGTGCTTGTAC
TAGGCTTAGTTATATGAATCTTTATAACACATAATTACTAACTTTGTAGCCATATATGTAATTGACTTTGAATGTTATTTACCTGAAATTAATCTTCCTT
CACACATGGACCGTAAACGGTTCCCAGTTGTCTGAGAGCCTCATGAGGGTTTCTAGGATTTATGACCTTATGACCAGTTTTTTTCATTTACCAAGATTTT
ATTTTCCTACATGAAAATTTAATTGAGTAATAATTATTCACATGTGCATTTTCTTTTTAGCTGTTAAATGTACTATGCCATCATCCACCATTTAGTAAAA
TGTAGCTGGCCCAGGACATGTAAAAAAAAAAAAAAAACAACAACAATAAATAGGGCATGTGAAATGTTAAGTTACAGCAATAGATATTTTATTTGTATTT
CATGTTAGTACTTTTTTGTTTTATATCACTTATAAAGGTACAGTGTACTCTTTGTCACAGCTCAGTTGGTAACCGCATTCCATTGAAAAGTTGGCCTTGT
AAAATACAACTCTCATTTAATATTCATGCTTTTGTGCCTTTAAGAAAATATTTTTTGTCATTTTTTGTGTTACAGAACTATAATGTGATTCAAGGTGTTT
ATAGGCTTGTCATAAAAGGGTCATTTCTGTGTGTTACTTTCTTTTTATATAGCTATAGTATATTTAAACAATAATACTATCTTTTATAGGGGTTTGTCTA
TTTACCTATTCTTTACTCAGACATTGATGTAGACTTGTCAGATTATTCTGAGTATTGTTAACAGTGCCTTTTCGATGGAATCACACTTTTTGGCTGTCAC
CTTGTGCCATATACACACAAAATTTTGTGGAAGGCAGTTTTAACTTTCTGAAGAATATCTGTCAAAATTTAAGAAAACAAATGTATAAAATTCCATTTTT
TCCAGTGTTTAGCATTTCTAGTAAGCAGTGAGGTTGTTTGACATACAGTGATGATGGCATTATTGATAAGCCATACATGAGACTGCAGATTATATTGAAT
CATATTAAATGTACAGAAATAAAATATTAGATTTATATCAAATTTTCCAATTTGAACCAGTGGGGAAAATCCCACAGAAATCAGTAAGTTTACATTTCAA
TTTCTATCTTATTTGACTAAGTGGAAAGAGATTCTTTAAAATGTATAACCTGCCATTATGTAATTTGGTTTCATTTTATTCTACCTGTTGTGTGAGTTTA
GTATATTTAATTTACTTTTTGTTACTCTTTACATACTGTTTATTTTTGTTAGTTTTTAATTGAAGATGGACTGTTGAAATTGTATAGGACCAGTGTCTTA
TTAATATGATTAATATATTTAGAAGAGCCACGTGAAACCCATGACAAAATGAATGTGAATATTCTTTCTAAAAATTTAGAAAATGTTATCTTTTTGCATT
TATTATGTAAAACTGTTTTACAGTATCAAAATTTTTCACTTAAAGAAAAAAAATGCCATGAAACATTTGAACTGATGAGCCACAGAACTTCAGTTGAAAT
TTTTTTCACTTTTTAGCATGCTAAATATACATCTGAGTTTAAATGTTCTGTTTAATGGCCATTCATAAATTCAAGCACTACCACTGGTCAGTTTTGTGTG
ATAGAATAAAAATATGTTACCTGCAGTGTAAGTACAGCACACTGTCAAATTCTTTTCCTTAAGGTGCACAGTAAATGTACAGATAGTTATAGGCCACTGT
TTTGTAATGTAGTACATTTCTAATCTATTATTCCTAACCTATTATAACTGTTTGCAGAAAGAAAAGAATTTTTCTAATAATCTGTAAAATTATGCTAACT
TCTACAAGTAGGCTTCTAAATAAAATTTTTAAAAAGAGCAAA
- refseq_OSBPL8.F1 (forward primer)
- refseq_OSBPL8.R1 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
H*NVKDLRGSGCPERRRRGG*QH*AATRSWPGGGCSVSFGRRSSRCR*QAD*GKVGVRPGWWTSGPK
VPAPLGG*AGSASAAAGQRPSSRLAPQLPPTTA
AERSWGLTRRLRGLGPRRRGDLGGTGSLRPASL
GAPHGICRFTEWLHINGKRSINLSSFIMEGGLAD
GEPDRTSLLGDSKDVLGPSTVVANSDESQLLTP
GKMSQRQGKEAYPTPTKDLHQPSLSPASPHSQG
FERGKEDISQNKDESSLSMSKSKSESKLYNGSEK
DSSTSSKLTKKESLKVQKKNYREEKKRATKELL
STITDPSVIVMADWLKIRGTLKSWTKLWCVLKP
GVLLIYKTQKNGQWVGTVLLNACEIIERPSKKDG
FCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPS
SYLIIRATSESDGRCWMDALELALKCSSLLKRT
MIREGKEHDLSVSSDSTHVTFYGLLRANNLHSGD
NFQLNDSEIERQHFKDQDMYSDKSDKENDQEHD
ESDNEVMGKSEESDTDTSERQDDSYIEPEPVEP
LKETTYTEQSHEELGEAGEASQTETVSEENKSLI
WTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLS
DYYYHADFLSEAALEENPYFRLKKVVKWYLSGF
YKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFY
IAEQVSHHPPISAFYVSNRKDGFCLSGSILAKS
KFYGNSLSAILEGEARLTFLNRGEDYVMTMPYA
HCKGILYGTMTLELGGTVNITCQKTGYSAILEFK
LKPFLGSSDCVNQISGKLKLGKEVLATLEGHWD
SEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTV
KFEEQGDFESEKLWQRVTRAINAKDQTEATQEKY
VLEEAQRQAARDRKTKNEEWSCKLFELDPLTGE
WHYKFADTRPWDPLNDMIQFEKDGVIQTKVKHR
TPMVSVPKMKHKPTRQQKKVAKGYSSPEPDIQDS
SGSEAQSVKPSTRRKKGIELGDIQSSIESIKQT
QEEIKRNIMALRNHLVSSTPATDYFLQQKDYFI
IFLLILLQVIINFMFK*KFSTIESVN*KDLIWPG
TSVQVGLVFIKNHNIPKTKKPRR*M*RY*LFVS
FIFTLKQELSYLIIKVSYVLSARTFLAFVRMCL
HMSIINPHVYTIVSYVLLPDSSLCIL*YVLRYNV
NIVHNKKCYQSYKYM*SIFFIKQAQKFYQ*GIT
D*EMME**T*LIQYTTVKIICKALSSIIFLERK
KKYEWSK*IHRER*MANCFFKSLHKFFLTPRI*Y
L*MQVNIYTYVYISIKTLVCN*LD*L*YHLKHL
LKKVWSKLIAVLLSYFCFS*VSWFIT*AKF*RC
L*SI*SADNLCFFIMKTYFSFRLQCVQ*ISRI*K
NITSILLQKPKRGNKKRHFVVAFMCALKLVSVK
RVIS*VSTKSIKF*SLIFLLSSSLLSNFFLWQN
HNSLRFLLFRLRQIFLFVSSV*YFDFVFLRKYLY
SLKAIFAKVVQFRNMLF*NMS*NPESIDFEMFF
**K*RSERIIALTTFAFQ*EEAVK**NYNRLCH
DKYKIGK*IH*LVNYENQNDKKSLLFSLTNIAIL
SILRFL*RTISHVFLAK*CCIPYVHVK*CFKLI
KA*IRSTYTQYFHDIRTNGFLVIFYICQYNFCI
HILLHSAYSLIYDIL*ILYNLIFFMV*IS*LHTN
*LAYHKNHFISKPC*HFVLVTHLLGLWSYPRVC
CFHLVQIIFYLYGYLLRLNR*LCSLFLKFLFRA
NVMGSYPKSQKLFLKKEQSYS*LFFIH*KHASNL
IVLLLCF*LYESLSMN*TQNSGIGGLILDQCLY
*A*LYESL*HIITNFVAIYVIDFECYLPEINLP
SHMDRKRFPVV*EPHEGF*DL*PYDQFFSFTKIL
FSYMKI*LSNNYSHVHFLFSC*MYYAIIHHLVK
CSWPRTCKKKKKTTTINRACEMLSYSNRYFICI
SC*YFFVLYHL*RYSVLFVTAQLVTAFH*KVGLV
KYNSHLIFMLLCL*ENIFCHFLCYRTIM*FKVF
IGLS*KGHFCVLLSFYIAIVYLNNNTIFYRGLS
IYLFFTQTLM*TCQIILSIVNSAFSMESHFLAVT
LCHIHTKFCGRQF*LSEEYLSKFKKTNV*NSIF
SSV*HF**AVRLFDIQ**WHY**AIHETADYIE
SY*MYRNKILDLYQIFQFEPVGKIPQKSVSLHFN
FYLI*LSGKRFFKMYNLPLCNLVSFYSTCCVSL
VYLIYFLLLFTYCLFLLVFN*RWTVEIV*DQCL
INMINIFRRAT*NP*QNECEYSF*KFRKCYLFAF
IM*NCFTVSKFFT*RKKMP*NI*TDEPQNFS*N
FFHFLAC*IYI*V*MFCLMAIHKFKHYHWSVLC
DRIKICYLQCKYSTLSNSFP*GAQ*MYR*L*ATV
L*CSTFLIYYS*PIITVCRKKRIFLIICKIMLT
STSRLLNKIFKKSK
Frame 1
TRM*RIFAVLGAQKGGDAADDNIRPRRAPGQAAAVVLALDAAVAAAGSKPTEGRWGSARAGGPRGR
KFPPRSGAEPAVPPRPLGSALRPGSRPSCRRRQR
PREVGV*LDAYGASDPGAAATSEEPAPCVPPPW
ELRTGFADLQNGCTLMEREA*TYLLSLWREVWQ
MENLIELRFLVIAKMSLGHQLL*QTVTNLSF*HQ
ER*VSAKEKKLIQRQPKICISHLLVQQVLIARV
LKEGRKIFLKIKMNLHFLCQRASLNLNFIMAQR
RTVQLQANSQKKNLLRYKRKITEKKRKEPQRSCS
VQSQILLLLLWLIG*RFVVL*RAGPSYGVC*NL
GCY*SIKPKKMVSG*EQFF*MPVKSLNVHQKRM
AFVSNFSILWSNLFGQ*RVQKVKRLDPLLNPYLA
VI*SSELLQSQMEGAGWMLWSWL*NVLVFLNVQ
*SEKERNMT*AFHQIAHM*LSMAYYVLTISTVV
ITSS*MIVKLNDNILRTKICILINLIKKMIKNMM
SLIMR*WGKVKKVTQIHQKDKMTHISNLSLLSL
*RRLPTLNRAMKNLERQVRLLKQKLYLKKTKAL
SGHY*NKSVLAWTYPRWFCLHLFWNPVLSWINFQ
ITTIMQISYLRQLLKKILISV*RK**NGICQDS
IKSQRD*RNLIILYLARLSVVYGFIPEQTAKLF
ILLNRCPIIHQYLPFMLVIEKMDFALAVVSWLSL
SFMETHYLQY*REKHG*LS*IEVKIM**QCHTL
IVKEFFMVQ*HWSLVEQSILHVKKLDTVQYLNL
N*SHS*GVVTVLIKYQGNLNWEKKS*LLWKVIGI
VKFLLLIKRLIIQRFSGIQHLTLSNGD**GTL*
NLKNREILNQRNSGNG*LEP*MPKTKLKLPKRS
MFWKKLKDKLPGIGKQKMKSGLANYLNLIHSQEN
GITSLQIPDHGTHLMI*YSLKKMVLFRPK*NIV
LQWLASPK*NISQPGNRRK*QKAIPPQNLTFKT
PLEVKLNQ*NQVQEERKE*NWETFRVPSNL*NKH
RKKLKEILWLFEII*FQAHRPRIIFCNKKTTSS
FSS*FCFKS**TSCSSRSSLPLNQ*TRKI*FGL
GPVFKLVWSLLKITIFRKQKNLGDKCRGIDFSYL
LSSH*NKSYPI*LLK*AMC*VPGHF*LL*ECVY
I*V**THMYTQLSLMYSYLTVVFVFYSMF*DIM
LTLFITKNAINLINICNLFSS*NRHKSFISKELQ
IEK*WNNRHN*FNTLLLKSFAKHSAQLSS*KER
KSMNGQNEYIERDKWQIAFLKVYISFF*PLEFN
ICRCR*IYILTCISV*KHWCAINWIDYNTTLSTC
*KKCGQN*LLSFCLIFVFLKSAGS*HRPNSRDV
YRAFEVLIIYVFSL*KLILALDSSVFSE*VEYK
KI*PVFYFKSQKEAIRKDTLWWPLCVH*NWFL*N
V**VEYLRRVSSSEV*FFYYPPLFLVTSFCGKT
TIL*DSYCSG*GKFFCLFLQFNILILCFYVNIY
IP*KQFLPR*FSLGICCSKICLRILKA*ILKCFF
NENEGQRE*LP*PHLPFSRRRL*NSKIIIVYAM
INTRLVNKYIDW*IMRIKMIKRACFFP*PI*LS
*VSLGFCEEPFPMFSWQNNAVFHMYM*NDVLN**
KLK*DLPIPSIFMILEQMGFWLYFIFVNIIFVF
TFCYTLPIH*YMIFCKYCTI*SFLWFKLVNYIQ
IDWLITKIISSVNLVNILYW*PTS*DFGLIHVYV
VFIWSK*YFICMGIF*D*IGSCVLYF*NFFLEQ
MLWVLTQRVKNYFLRKSRVIHDCSLYTKSMHLI
**SSYYAFSCMSLFL*TEHKTQELVA*F*ISACT
RLSYMNLYNT*LLTL*PYM*LTLNVIYLKLIFL
HTWTVNGSQLSESLMRVSRIYDLMTSFFHLPRF
YFPT*KFN*VIIIHMCIFFLAVKCTMPSSTI**N
VAGPGHVKKKKKQQQ*IGHVKC*VTAIDILFVF
HVSTFLFYITYKGTVYSLSQLSW*PHSIEKLAL
*NTTLI*YSCFCAFKKIFFVIFCVTEL*CDSRCL
*ACHKRVISVCYFLFI*L*YI*TIILSFIGVCL
FTYSLLRH*CRLVRLF*VLLTVPFRWNHTFWLS
PCAIYTQNFVEGSFNFLKNICQNLRKQMYKIPFF
PVFSISSKQ*GCLTYSDDGIIDKPYMRLQIILN
HIKCTEIKY*IYIKFSNLNQWGKSHRNQ*VYIS
ISILFD*VERDSLKCITCHYVIWFHFILPVV*V*
YI*FTFCYSLHTVYFC*FLIEDGLLKLYRTSVL
LI*LIYLEEPRETHDKMNVNILSKNLENVIFLH
LLCKTVLQYQNFSLKEKKCHETFELMSHRTSVEI
FFTF*HAKYTSEFKCSV*WPFINSSTTTGQFCV
IE*KYVTCSVSTAHCQILFLKVHSKCTDSYRPL
FCNVVHF*SIIPNLL*LFAERKEFF**SVKLC*L
LQVGF*IKFLKRA
Frame 2
LECEGSSRFWVPRKAATRRMTTLGRDALLARRRL*C*LWTPQ*PLPVASRLREGGGPPGLVDLGAE
SSRPARGLSRQCLRGRWAAPFVQARAPAAADDS
GREKLGSD*TLTGPRTPAPRRPRRNRLLASRLPG
SSARDLQIYRMAAH*WKEKHKPIFFHYGGRFGR
WRT*SNFASW**QRCPWAINCCSKQ*RISASDT
RKDESAPRKRSLSNANQRFASAIS*SSKSS*PGF
*KREGRYFSK*R*IFTFYVKEQV*I*TL*WLRE
GQFNFKQTHKKRIS*GTKEKLPRRKEKSHKGAA
QYNHRSFCYCYG*LVKDSWYSKELDQVMVCVETW
GATDL*NPKKWSVGRNSSSECL*NH*TSIKKGW
LLFQTFPSFGAIYLGSEGSKR*SGWIHYSTLT*
QLFDHPSYFRVRWKVLDGCFGVGFEMF*SS*TYN
DQRRKGT*PERFIR*HTCDFLWLTTC*QSPQW*
*LPVK***N*TTTF*GPRYVF**I**RK*SRT*
*V***GDGEK*RK*HRYIRKTR*LIYRT*AC*AF
KGDYLH*TEP*RTWRGR*GFSNRNCI*RKQKPY
LDTIETSPSWHGPIQGGSAYIYFGTPFFPG*TF
RLLLSCRFPI*GSS*RKSLFPFEESSEMVFVRIL
*KAKGTEETL*SYTWRDFPLFMDSSQNKQQNFL
YC*TGVPSSTNICLLC**SKRWILP*R*YPG*V
*VLWKLIICNIRGRSTVNFLE*R*RLCNDNAIRS
L*RNSLWYNDTGAWWNSQYYMSKNWIQCNT*I*
TKAIPRE**LC*SNIRET*TGKRSPSYFGRSLG
**SFYY**KD**FRGFLESNT*H*AMEINKAHCK
I*RTGRF*IRETLATGNSSHKCQRPN*SYPREV
CFGRSSKTSCQGSENKK*RVVLQII*T*STHRR
MALQVCRYPTMGPT**YDTV*KRWCYSDQSETSY
SNG*RPQNET*ANQATEESSKRLFLPRT*HSRL
LWK*SSISKTKYKKKERNRTGRHSEFHRIYKTN
TGRN*KKYYGSSKSFSFKHTGHGLFSATKRLLHH
FPPDFASSHNKLHVQVEVLYH*ISELERSDLAW
DQCSSWFGLY*KSQYSENKKT*EINVEVLTFRI
FYLHTETRAILFDY*SELCVKCQDISSFCENVST
YEYNKPTCIHNCLLCTPT*Q*SLYSIVCSEI*C
*HCS*QKMLSIL*IYVIYFLHKTGTKVLSVRNY
RLRNDGIIDIINSIHYC*NHLQSTQLNYLLRKKE
KV*MVKMNTSREINGKLLF*KFT*VFFNP*NLI
FVDAGKYIYLRVYQYKNTGVQLIGLIIIPP*AL
AEKSVVKIDCCPFVLFLFFLSQLVHNIGQILEMF
IEHLKC**FMFFHYENLF*L*TPVCSVNK*NIK
KYNQYFTSKAKKRQ*EKTLCGGLYVCIKIGFCK
TCNKLSIYEEYQVLKFNFFIILLSS**LLSVAKP
QFFKIPIVQAKANFFVCFFSLIF*FCVFT*IFI
FLESNFCQGSSV*EYVVLKYVLES*KHRF*NVF
LMKMKVRENNCPDHICLSVGGGCEIVKL*SFMP*
*IQDW*INTLIGKL*ESK**KEPAFFPNQYSYL
KYP*VSVKNHFPCFLGKIMLYSICTCEMMF*ID
KSLNKIYLYPVFS*Y*NKWVFGYILYLSI*FLYS
HSVTLCLFIDI*YSVNIVQFDLFYGLN*LITYK
LIGLSQKSFHQ*TLLTFCTGDPPLRTLVLSTCM
LFSFGPNNILFVWVSSKTK*VVVFFIFKISF*SK
CYGFLPKESKTIS*ERAELFMTVLYTLKACI*S
NSPLIMLLVV*VSFYELNTKLRNWWLNFRSVLV
LGLVI*IFITHNY*LCSHICN*L*MLFT*N*SSF
THGP*TVPSCLRAS*GFLGFMTL*PVFFIYQDF
IFLHENLIE**LFTCAFSF*LLNVLCHHPPFSK
M*LAQDM*KKKKNNNNK*GM*NVKLQQ*IFYLYF
MLVLFCFISLIKVQCTLCHSSVGNRIPLKSWPC
KIQLSFNIHAFVPLRKYFLSFFVLQNYNVIQGV
YRLVIKGSFLCVTFFLYSYSIFKQ*YYLL*GFVY
LPILYSDIDVDLSDYSEYC*QCLFDGITLFGCH
LVPYTHKILWKAVLTF*RISVKI*ENKCIKFHF
FQCLAFLVSSEVV*HTVMMALLISHT*DCRLY*I
ILNVQK*NIRFISNFPI*TSGENPTEISKFTFQ
FLSYLTKWKEIL*NV*PAIM*FGFILFYLLCEF
SIFNLLFVTLYILFIFVSF*LKMDC*NCIGPVSY
*YD*YI*KSHVKPMTK*M*IFFLKI*KMLSFCI
YYVKLFYSIKIFHLKKKNAMKHLN**ATELQLK
FFSLFSMLNIHLSLNVLFNGHS*IQALPLVSFV*
*NKNMLPAV*VQHTVKFFSLRCTVNVQIVIGHC
FVM*YISNLLFLTYYNCLQKEKNFSNNL*NYAN
FYK*ASK*NF*KEQ
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