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Sequences

Sequence NM_152880

GCGGCGCGCGGGGACTCGGAGGTACTGGGCGCGCGCGGCTCCGGCTCGGGACGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGG CGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCGGAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGAT GGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTACCCAGACAGCCATTGTCTTC ATCAAGCAGCCGTCCTCCCAGGATGCACTGCAGGGGCGCCGGGCGCTGCTTCGCTGTGAGGTTGAGGCTCCGGGCCCGGTACATGTGTACTGGCTGCTCG ATGGGGCCCCTGTCCAGGACACGGAGCGGCGTTTCGCCCAGGGCAGCAGCCTGAGCTTTGCAGCTGTGGACCGGCTGCAGGACTCTGGCACCTTCCAGTG TGTGGCTCGGGATGATGTCACTGGAGAAGAAGCCCGCAGTGCCAACGCCTCCTTCAACATCAAATGGATTGAGGCAGGTCCTGTGGTCCTGAAGCATCCA GCCTCGGAAGCTGAGATCCAGCCACAGACCCAGGTCACACTTCGTTGCCACATTGATGGGCACCCTCGGCCCACCTACCAATGGTTCCGAGATGGGACCC CCCTTTCTGATGGTCAGAGCAACCACACAGTCAGCAGCAAGGAGCGGAACCTGACGCTCCGGCCAGCTGGTCCTGAGCATAGTGGGCTGTATTCCTGCTG CGCCCACAGTGCTTTTGGCCAGGCTTGCAGCAGCCAGAACTTCACCTTGAGCATTGCTGATGAAAGCTTTGCCAGGGTGGTGCTGGCACCCCAGGACGTG GTAGTAGCGAGGTATGAGGAGGCCATGTTCCATTGCCAGTTCTCAGCCCAGCCACCCCCGAGCCTGCAGTGGCTCTTTGAGGATGAGACTCCCATCACTA ACCGCAGTCGCCCCCCACACCTCCGCAGAGCCACAGTGTTTGCCAACGGGTCTCTGCTGCTGACCCAGGTCCGGCCACGCAATGCAGGGATCTACCGCTG CATTGGCCAGGGGCAGAGGGGCCCACCCATCATCCTGGAAGCCACACTTCACCTAGCAGAGATTGAAGACATGCCGCTATTTGAGCCACGGGTGTTTACA GCTGGCAGCGAGGAGCGTGTGACCTGCCTTCCCCCCAAGGGTCTGCCAGAGCCCAGCGTGTGGTGGGAGCACGCGGGAGTCCGGCTGCCCACCCATGGCA GGGTCTACCAGAAGGGCCACGAGCTGGTGTTGGCCAATATTGCTGAAAGTGATGCTGGTGTCTACACCTGCCACGCGGCCAACCTGGCTGGTCAGCGGAG ACAGGATGTCAACATCACTGTGGCCACTGTGCCCTCCTGGCTGAAGAAGCCCCAAGACAGCCAGCTGGAGGAGGGCAAACCCGGCTACTTGGATTGCCTG ACCCAGGCCACACCAAAACCTACAGTTGTCTGGTACAGAAACCAGATGCTCATCTCAGAGGACTCACGGTTCGAGGTCTTCAAGAATGGGACCTTGCGCA TCAACAGCGTGGAGGTGTATGATGGGACATGGTACCGTTGTATGAGCAGCACCCCAGCCGGCAGCATCGAGGCGCAAGCCCGTGTCCAAGTGCTGGATGG GAGCAGCCTCCCAGAGTGGGTGACAGACAACGCTGGGACCCTGCATTTTGCCCGGGTGACTCGAGATGACGCTGGCAACTACACTTGCATTGCCTCCAAC GGGCCGCAGGGCCAGATTCGTGCCCATGTCCAGCTCACTGTGGCAGTTTTTATCACCTTCAAAGTGGAACCAGAGCGTACGACTGTGTACCAGGGCCACA CAGCCCTACTGCAGTGCGAGGCCCAGGGGGACCCCAAGCCGCTGATTCAGTGGAAAGGCAAGGACCGCATCCTGGACCCCACCAAGCTGGGACCCAGGAT GCACATCTTCCAGAATGGCTCCCTGGTGATCCATGACGTGGCCCCTGAGGACTCAGGCCGCTACACCTGCATTGCAGGCAACAGCTGCAACATCAAGCAC ACGGAGGCCCCCCTCTATGTCGTGGACAAGCCTGTGCCGGAGGAGTCGGAGGGCCCTGGCAGCCCTCCCCCCTACAAGATGATCCAGACCATTGGGTTGT CGGTGGGTGCCGCTGTGGCCTACATCATTGCCGTGCTGGGCCTCATGTTCTACTGCAAGAAGCGCTGCAAAGCCAAGCGGCTGCAGAAGCAGCCCGAGGG CGAGGAGCCAGAGATGGAATGCCTCAACGGTGGGCCTTTGCAGAACGGGCAGCCCTCAGCAGAGATCCAAGAAGAAGTGGCCTTGACCAGCTTGGGCTCC GGCCCCGCGGCCACCAACAAACGCCACAGCACAAGTGATAAGATGCACTTCCCACGGTCTAGCCTGCAGCCCATCACCACGCTGGGGAAGAGTGAGTTTG GGGAGGTGTTCCTGGCAAAGGCTCAGGGCTTGGAGGAGGGAGTGGCAGAGACCCTGGTACTTGTGAAGAGCCTGCAGAGCAAGGATGAGCAGCAGCAGCT GGACTTCCGGAGGGAGTTGGAGATGTTTGGGAAGCTGAACCACGCCAACGTGGTGCGGCTCCTGGGGCTGTGCCGGGAGGCTGAGCCCCACTACATGGTG CTGGAATATGTGGATCTGGGAGACCTCAAGCAGTTCCTGAGGATTTCCAAGAGCAAGGATGAAAAATTGAAGTCACAGCCCCTCAGCACCAAGCAGAAGG TGGCCCTATGCACCCAGGTAGCCCTGGGCATGGAGCACCTGTCCAACAACCGCTTTGTGCATAAGGACTTGGCTGCGCGTAACTGCCTGGTCAGTGCCCA GAGACAAGTGAAGGTGTCTGCCCTGGGCCTCAGCAAGGATGTGTACAACAGTGAGTACTACCACTTCCGCCAGGCCTGGGTGCCGCTGCGCTGGATGTCC CCCGAGGCCATCCTGGAGGGTGACTTCTCTACCAAGTCTGATGTCTGGGCCTTCGGTGTGCTGATGTGGGAAGTGTTTACACATGGAGAGATGCCCCATG GTGGGCAGGCAGATGATGAAGTACTGGCAGATTTGCAGGCTGGGAAGGCTAGACTTCCTCAGCCCGAGGGCTGCCCTTCCAAACTCTATCGGCTGATGCA GCGCTGCTGGGCCCTCAGCCCCAAGGACCGGCCCTCCTTCAGTGAGATTGCCAGCGCCCTGGGAGACAGCACCGTGGACAGCAAGCCGTGAGGAGGGAGC CCGCTCAGGATGGCCTGGGCAGGGGAGGACATCTCTAGAGGGAAGCTCACAGCATGATGGGCAAGATCCCTGTCCTCCTGGGCCCTGAGGCCCCTGCCCT AGTGCAACAGGCATTGCTGAGGTCTGAGCAGGGCCTGGCCTTTCCTCCTCTTCCTCACCCTCATCCTTTGGGAGGCTGACTTGGACCCAAACTGGGCGAC TAGGGCTTTGAGCTGGGCAGTTTTCCCTGCCACCTCTTCCTCTATCAGGGACAGTGTGGGTGCCACAGGTAACCCCAATTTCTGGCCTTCAACTTCTCCC CTTGACCGGGTCCAACTCTGCCACTCATCTGCCAACTTTGCCTGGGGAGGGCTAGGCTTGGGATGAGCTGGGTTTGTGGGGAGTTCCTTAATATTCTCAA GTTCTGGGCACACAGGGTTAATGAGTCTCTTGGCCCACTGGTCCCACTTGGGGGTCTAGACCAGGATTATAGAGGACACAGCAAGTGAGTCCTCCCCACT CTGGGCTTGTGCACACTGACCCAGACCCACGTCTTCCCCACCCTTCTCTCCTTTCCTCATCCTAAGTGCCTGGCAGATGAAGGAGTTTTCAGGAGCTTTT GACACTATATAAACCGCCCTTTTTGTATGCACCACGGGCGGCTTTTATATGTAATTGCAGCGTGGGGTGGGTGGGCATGGGAGGTAGGGGTGGGCCCTGG AGATGAGGAGGGTGGGCCATCCTTACCCCACACTTTTATTGTTGTCGTTTTTTGTTTGTTTTGTTTTTTTGTTTTTGTTTTTGTTTTTACACTCGCTGCT CTCAATAAATAAGCCTTTTTTACAACCTG

refseq_PTK7.F1 (forward primer)
refseq_PTK7.R1 (reverse primer)
Single exon skipping

Frame 0

AARGDSEVLGARGSGSGRLGTPRGRAPAAAAAA APALRCAPPPVPAAERSLRARRAPSAPFPEPAAM GAARGSPARPRRLPLLSVLLLPLLGGTQTAIVF IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLL DGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQC VARDDVTGEEARSANASFNIKWIEAGPVVLKHP ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGT PLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCC AHSAFGQACSSQNFTLSIADESFARVVLAPQDV VVARYEEAMFHCQFSAQPPPSLQWLFEDETPIT NRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRC IGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT AGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHG RVYQKGHELVLANIAESDAGVYTCHAANLAGQRR QDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL TQATPKPTVVWYRNQMLISEDSRFEVFKNGTLR INSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDG SSLPEWVTDNAGTLHFARVTRDDAGNYTCIASN GPQGQIRAHVQLTVAVFITFKVEPERTTVYQGH TALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRM HIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKH TEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGL SVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEG EEPEMECLNGGPLQNGQPSAEIQEEVALTSLGS GPAATNKRHSTSDKMHFPRSSLQPITTLGKSEF GEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQL DFRRELEMFGKLNHANVVRLLGLCREAEPHYMV LEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQK VALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQ RQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMS PEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPH GGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQ RCWALSPKDRPSFSEIASALGDSTVDSKP*GGS PLRMAWAGEDISRGKLTA*WARSLSSWALRPLP *CNRHC*GLSRAWPFLLFLTLILWEADLDPNWAT RALSWAVFPATSSSIRDSVGATGNPNFWPSTSP LDRVQLCHSSANFAWGGLGLG*AGFVGSSLIFS SSGHTGLMSLLAHWSHLGV*TRIIEDTASESSPL WACAH*PRPTSSPPFSPFLILSAWQMKEFSGAF DTI*TALFVCTTGGFYM*LQRGVGGHGR*GWAL EMRRVGHPYPTLLLLSFFVCFVFLFLFLFLHSLL SINKPFLQP

Frame 1

RRAGTRRYWARAAPARDASGRLGVGLRLRLLLR RPRSGALRLLCPPRSAVCAPAVRPQLLFLSPPR WELRGDPRPDPAGCLCSASCCCRCWAVPRQPLSS SSSRPPRMHCRGAGRCFAVRLRLRARYMCTGCS MGPLSRTRSGVSPRAAA*ALQLWTGCRTLAPSS VWLGMMSLEKKPAVPTPPSTSNGLRQVLWS*SIQ PRKLRSSHRPRSHFVATLMGTLGPPTNGSEMGP PFLMVRATTQSAARSGT*RSGQLVLSIVGCIPA APTVLLARLAAARTSP*ALLMKALPGWCWHPRTW **RGMRRPCSIASSQPSHPRACSGSLRMRLPSL TAVAPHTSAEPQCLPTGLCC*PRSGHAMQGSTA ALARGRGAHPSSWKPHFT*QRLKTCRYLSHGCLQ LAARSV*PAFPPRVCQSPACGGSTRESGCPPMA GSTRRATSWCWPILLKVMLVSTPATRPTWLVSG DRMSTSLWPLCPPG*RSPKTASWRRANPATWIA* PRPHQNLQLSGTETRCSSQRTHGSRSSRMGPCA STAWRCMMGHGTVV*AAPQPAASRRKPVSKCWM GAASQSG*QTTLGPCILPG*LEMTLATTLALPPT GRRARFVPMSSSLWQFLSPSKWNQSVRLCTRAT QPYCSARPRGTPSR*FSGKARTASWTPPSWDPG CTSSRMAPW*SMTWPLRTQAATPALQATAATSST RRPPSMSWTSLCRRSRRALAALPPTR*SRPLGC RWVPLWPTSLPCWASCSTARSAAKPSGCRSSPR ARSQRWNASTVGLCRTGSPQQRSKKKWP*PAWAP APRPPTNATAQVIRCTSHGLACSPSPRWGRVSL GRCSWQRLRAWRREWQRPWYL*RACRARMSSSS WTSGGSWRCLGS*TTPTWCGSWGCAGRLSPTTWC WNMWIWETSSSS*GFPRARMKN*SHSPSAPSRR WPYAPR*PWAWSTCPTTALCIRTWLRVTAWSVP RDK*RCLPWASARMCTTVSTTTSARPGCRCAGCP PRPSWRVTSLPSLMSGPSVC*CGKCLHMERCPM VGRQMMKYWQICRLGRLDFLSPRAALPNSIG*C SAAGPSAPRTGPPSVRLPAPWETAPWTASREEGA RSGWPGQGRTSLEGSSQHDGQDPCPPGP*GPCP SATGIAEV*AGPGLSSSSSPSSFGRLTWTQTGR LGL*AGQFSLPPLPLSGTVWVPQVTPISGLQLLP LTGSNSATHLPTLPGEG*AWDELGLWGVP*YSQ VLGTQG**VSWPTGPTWGSRPGL*RTQQVSPPH SGLVHTDPDPRLPHPSLLSSS*VPGR*RSFQELL TLYKPPFLYAPRAAFICNCSVGWVGMGGRGGPW R*GGWAILTPHFYCCRFLFVLFFCFCFCFYTRC SQ*ISLFYNL

Frame 2

GARGLGGTGRARLRLGTPRDASGSGSGCGCCCG ARAPVRSASCARRGAQSARPPCALSSFS*ARRD GSCAGIPGQTPPVASAQRPAAAAAGRYPDSHCL HQAAVLPGCTAGAPGAASL*G*GSGPGTCVLAAR WGPCPGHGAAFRPGQQPELCSCGPAAGLWHLPV CGSG*CHWRRSPQCQRLLQHQMD*GRSCGPEAS SLGS*DPATDPGHTSLPH*WAPSAHLPMVPRWDP PF*WSEQPHSQQQGAEPDAPASWS*A*WAVFLL RPQCFWPGLQQPELHLEHC**KLCQGGAGTPGR GSSEV*GGHVPLPVLSPATPEPAVAL*G*DSHH* PQSPPTPPQSHSVCQRVSAADPGPATQCRDLPL HWPGAEGPTHHPGSHTSPSRD*RHAAI*ATGVY SWQRGACDLPSPQGSARAQRVVGARGSPAAHPWQ GLPEGPRAGVGQYC*K*CWCLHLPRGQPGWSAE TGCQHHCGHCALLAEEAPRQPAGGGQTRLLGLP DPGHTKTYSCLVQKPDAHLRGLTVRGLQEWDLAH QQRGGV*WDMVPLYEQHPSRQHRGASPCPSAGW EQPPRVGDRQRWDPAFCPGDSR*RWQLHLHCLQ RAAGPDSCPCPAHCGSFYHLQSGTRAYDCVPGPH SPTAVRGPGGPQAADSVERQGPHPGPHQAGTQD AHLPEWLPGDP*RGP*GLRPLHLHCRQQLQHQA HGGPPLCRGQACAGGVGGPWQPSPLQDDPDHWVV GGCRCGLHHCRAGPHVLLQEALQSQAAAEAARG RGARDGMPQRWAFAERAALSRDPRRSGLDQLGL RPRGHQQTPQHK**DALPTV*PAAHHHAGEE*VW GGVPGKGSGLGGGSGRDPGTCEEPAEQG*AAAA GLPEGVGDVWEAEPRQRGAAPGAVPGG*APLHG AGICGSGRPQAVPEDFQEQG*KIEVTAPQHQAEG GPMHPGSPGHGAPVQQPLCA*GLGCA*LPGQCP ETSEGVCPGPQQGCVQQ*VLPLPPGLGAAALDV PRGHPGG*LLYQV*CLGLRCADVGSVYTWRDAPW WAGR**STGRFAGWEG*TSSARGLPFQTLSADA ALLGPQPQGPALLQ*DCQRPGRQHRGQQAVRRE PAQDGLGRGGHL*REAHSMMGKIPVLLGPEAPAL VQQALLRSEQGLAFPPLPHPHPLGG*LGPKLGD *GFELGSFPCHLFLYQGQCGCHR*PQFLAFNFS P*PGPTLPLICQLCLGRARLGMSWVCGEFLNILK FWAHRVNESLGPLVPLGGLDQDYRGHSK*VLPT LGLCTLTQTHVFPTLLSFPHPKCLADEGVFRSF *HYINRPFCMHHGRLLYVIAAWGGWAWEVGVGPG DEEGGPSLPHTFIVVVFCLFCFFVFVFVFTLAA LNK*AFFTT

Sequence NM_002821

GCGGCGCGCGGGGACTCGGAGGTACTGGGCGCGCGCGGCTCCGGCTCGGGACGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGG CGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCGGAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGAT GGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTACCCAGACAGCCATTGTCTTC ATCAAGCAGCCGTCCTCCCAGGATGCACTGCAGGGGCGCCGGGCGCTGCTTCGCTGTGAGGTTGAGGCTCCGGGCCCGGTACATGTGTACTGGCTGCTCG ATGGGGCCCCTGTCCAGGACACGGAGCGGCGTTTCGCCCAGGGCAGCAGCCTGAGCTTTGCAGCTGTGGACCGGCTGCAGGACTCTGGCACCTTCCAGTG TGTGGCTCGGGATGATGTCACTGGAGAAGAAGCCCGCAGTGCCAACGCCTCCTTCAACATCAAATGGATTGAGGCAGGTCCTGTGGTCCTGAAGCATCCA GCCTCGGAAGCTGAGATCCAGCCACAGACCCAGGTCACACTTCGTTGCCACATTGATGGGCACCCTCGGCCCACCTACCAATGGTTCCGAGATGGGACCC CCCTTTCTGATGGTCAGAGCAACCACACAGTCAGCAGCAAGGAGCGGAACCTGACGCTCCGGCCAGCTGGTCCTGAGCATAGTGGGCTGTATTCCTGCTG CGCCCACAGTGCTTTTGGCCAGGCTTGCAGCAGCCAGAACTTCACCTTGAGCATTGCTGATGAAAGCTTTGCCAGGGTGGTGCTGGCACCCCAGGACGTG GTAGTAGCGAGGTATGAGGAGGCCATGTTCCATTGCCAGTTCTCAGCCCAGCCACCCCCGAGCCTGCAGTGGCTCTTTGAGGATGAGACTCCCATCACTA ACCGCAGTCGCCCCCCACACCTCCGCAGAGCCACAGTGTTTGCCAACGGGTCTCTGCTGCTGACCCAGGTCCGGCCACGCAATGCAGGGATCTACCGCTG CATTGGCCAGGGGCAGAGGGGCCCACCCATCATCCTGGAAGCCACACTTCACCTAGCAGAGATTGAAGACATGCCGCTATTTGAGCCACGGGTGTTTACA GCTGGCAGCGAGGAGCGTGTGACCTGCCTTCCCCCCAAGGGTCTGCCAGAGCCCAGCGTGTGGTGGGAGCACGCGGGAGTCCGGCTGCCCACCCATGGCA GGGTCTACCAGAAGGGCCACGAGCTGGTGTTGGCCAATATTGCTGAAAGTGATGCTGGTGTCTACACCTGCCACGCGGCCAACCTGGCTGGTCAGCGGAG ACAGGATGTCAACATCACTGTGGCCACTGTGCCCTCCTGGCTGAAGAAGCCCCAAGACAGCCAGCTGGAGGAGGGCAAACCCGGCTACTTGGATTGCCTG ACCCAGGCCACACCAAAACCTACAGTTGTCTGGTACAGAAACCAGATGCTCATCTCAGAGGACTCACGGTTCGAGGTCTTCAAGAATGGGACCTTGCGCA TCAACAGCGTGGAGGTGTATGATGGGACATGGTACCGTTGTATGAGCAGCACCCCAGCCGGCAGCATCGAGGCGCAAGCCCGTGTCCAAGTGCTGGAAAA GCTCAAGTTCACACCACCACCCCAGCCACAGCAGTGCATGGAGTTTGACAAGGAGGCCACGGTGCCCTGTTCAGCCACAGGCCGAGAGAAGCCCACTATT AAGTGGGAACGGGCAGATGGGAGCAGCCTCCCAGAGTGGGTGACAGACAACGCTGGGACCCTGCATTTTGCCCGGGTGACTCGAGATGACGCTGGCAACT ACACTTGCATTGCCTCCAACGGGCCGCAGGGCCAGATTCGTGCCCATGTCCAGCTCACTGTGGCAGTTTTTATCACCTTCAAAGTGGAACCAGAGCGTAC GACTGTGTACCAGGGCCACACAGCCCTACTGCAGTGCGAGGCCCAGGGGGACCCCAAGCCGCTGATTCAGTGGAAAGGCAAGGACCGCATCCTGGACCCC ACCAAGCTGGGACCCAGGATGCACATCTTCCAGAATGGCTCCCTGGTGATCCATGACGTGGCCCCTGAGGACTCAGGCCGCTACACCTGCATTGCAGGCA ACAGCTGCAACATCAAGCACACGGAGGCCCCCCTCTATGTCGTGGACAAGCCTGTGCCGGAGGAGTCGGAGGGCCCTGGCAGCCCTCCCCCCTACAAGAT GATCCAGACCATTGGGTTGTCGGTGGGTGCCGCTGTGGCCTACATCATTGCCGTGCTGGGCCTCATGTTCTACTGCAAGAAGCGCTGCAAAGCCAAGCGG CTGCAGAAGCAGCCCGAGGGCGAGGAGCCAGAGATGGAATGCCTCAACGGTGGGCCTTTGCAGAACGGGCAGCCCTCAGCAGAGATCCAAGAAGAAGTGG CCTTGACCAGCTTGGGCTCCGGCCCCGCGGCCACCAACAAACGCCACAGCACAAGTGATAAGATGCACTTCCCACGGTCTAGCCTGCAGCCCATCACCAC GCTGGGGAAGAGTGAGTTTGGGGAGGTGTTCCTGGCAAAGGCTCAGGGCTTGGAGGAGGGAGTGGCAGAGACCCTGGTACTTGTGAAGAGCCTGCAGAGC AAGGATGAGCAGCAGCAGCTGGACTTCCGGAGGGAGTTGGAGATGTTTGGGAAGCTGAACCACGCCAACGTGGTGCGGCTCCTGGGGCTGTGCCGGGAGG CTGAGCCCCACTACATGGTGCTGGAATATGTGGATCTGGGAGACCTCAAGCAGTTCCTGAGGATTTCCAAGAGCAAGGATGAAAAATTGAAGTCACAGCC CCTCAGCACCAAGCAGAAGGTGGCCCTATGCACCCAGGTAGCCCTGGGCATGGAGCACCTGTCCAACAACCGCTTTGTGCATAAGGACTTGGCTGCGCGT AACTGCCTGGTCAGTGCCCAGAGACAAGTGAAGGTGTCTGCCCTGGGCCTCAGCAAGGATGTGTACAACAGTGAGTACTACCACTTCCGCCAGGCCTGGG TGCCGCTGCGCTGGATGTCCCCCGAGGCCATCCTGGAGGGTGACTTCTCTACCAAGTCTGATGTCTGGGCCTTCGGTGTGCTGATGTGGGAAGTGTTTAC ACATGGAGAGATGCCCCATGGTGGGCAGGCAGATGATGAAGTACTGGCAGATTTGCAGGCTGGGAAGGCTAGACTTCCTCAGCCCGAGGGCTGCCCTTCC AAACTCTATCGGCTGATGCAGCGCTGCTGGGCCCTCAGCCCCAAGGACCGGCCCTCCTTCAGTGAGATTGCCAGCGCCCTGGGAGACAGCACCGTGGACA GCAAGCCGTGAGGAGGGAGCCCGCTCAGGATGGCCTGGGCAGGGGAGGACATCTCTAGAGGGAAGCTCACAGCATGATGGGCAAGATCCCTGTCCTCCTG GGCCCTGAGGCCCCTGCCCTAGTGCAACAGGCATTGCTGAGGTCTGAGCAGGGCCTGGCCTTTCCTCCTCTTCCTCACCCTCATCCTTTGGGAGGCTGAC TTGGACCCAAACTGGGCGACTAGGGCTTTGAGCTGGGCAGTTTTCCCTGCCACCTCTTCCTCTATCAGGGACAGTGTGGGTGCCACAGGTAACCCCAATT TCTGGCCTTCAACTTCTCCCCTTGACCGGGTCCAACTCTGCCACTCATCTGCCAACTTTGCCTGGGGAGGGCTAGGCTTGGGATGAGCTGGGTTTGTGGG GAGTTCCTTAATATTCTCAAGTTCTGGGCACACAGGGTTAATGAGTCTCTTGGCCCACTGGTCCCACTTGGGGGTCTAGACCAGGATTATAGAGGACACA GCAAGTGAGTCCTCCCCACTCTGGGCTTGTGCACACTGACCCAGACCCACGTCTTCCCCACCCTTCTCTCCTTTCCTCATCCTAAGTGCCTGGCAGATGA AGGAGTTTTCAGGAGCTTTTGACACTATATAAACCGCCCTTTTTGTATGCACCACGGGCGGCTTTTATATGTAATTGCAGCGTGGGGTGGGTGGGCATGG GAGGTAGGGGTGGGCCCTGGAGATGAGGAGGGTGGGCCATCCTTACCCCACACTTTTATTGTTGTCGTTTTTTGTTTGTTTTGTTTTTTTGTTTTTGTTT TTGTTTTTACACTCGCTGCTCTCAATAAATAAGCCTTTTTTACAACCTG

refseq_PTK7.F1 (forward primer)
refseq_PTK7.R1 (reverse primer)
Single exon skipping

Frame 0

AARGDSEVLGARGSGSGRLGTPRGRAPAAAAAA APALRCAPPPVPAAERSLRARRAPSAPFPEPAAM GAARGSPARPRRLPLLSVLLLPLLGGTQTAIVF IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLL DGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQC VARDDVTGEEARSANASFNIKWIEAGPVVLKHP ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGT PLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCC AHSAFGQACSSQNFTLSIADESFARVVLAPQDV VVARYEEAMFHCQFSAQPPPSLQWLFEDETPIT NRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRC IGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT AGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHG RVYQKGHELVLANIAESDAGVYTCHAANLAGQRR QDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL TQATPKPTVVWYRNQMLISEDSRFEVFKNGTLR INSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEK LKFTPPPQPQQCMEFDKEATVPCSATGREKPTI KWERADGSSLPEWVTDNAGTLHFARVTRDDAGN YTCIASNGPQGQIRAHVQLTVAVFITFKVEPERT TVYQGHTALLQCEAQGDPKPLIQWKGKDRILDP TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAG NSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKM IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKR LQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV ALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITT LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQS KDEQQQLDFRRELEMFGKLNHANVVRLLGLCRE AEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP LSTKQKVALCTQVALGMEHLSNNRFVHKDLAAR NCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAW VPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFT HGEMPHGGQADDEVLADLQAGKARLPQPEGCPS KLYRLMQRCWALSPKDRPSFSEIASALGDSTVD SKP*GGSPLRMAWAGEDISRGKLTA*WARSLSSW ALRPLP*CNRHC*GLSRAWPFLLFLTLILWEAD LDPNWATRALSWAVFPATSSSIRDSVGATGNPN FWPSTSPLDRVQLCHSSANFAWGGLGLG*AGFVG SSLIFSSSGHTGLMSLLAHWSHLGV*TRIIEDT ASESSPLWACAH*PRPTSSPPFSPFLILSAWQM KEFSGAFDTI*TALFVCTTGGFYM*LQRGVGGHG R*GWALEMRRVGHPYPTLLLLSFFVCFVFLFLF LFLHSLLSINKPFLQP

Frame 1

RRAGTRRYWARAAPARDASGRLGVGLRLRLLLR RPRSGALRLLCPPRSAVCAPAVRPQLLFLSPPR WELRGDPRPDPAGCLCSASCCCRCWAVPRQPLSS SSSRPPRMHCRGAGRCFAVRLRLRARYMCTGCS MGPLSRTRSGVSPRAAA*ALQLWTGCRTLAPSS VWLGMMSLEKKPAVPTPPSTSNGLRQVLWS*SIQ PRKLRSSHRPRSHFVATLMGTLGPPTNGSEMGP PFLMVRATTQSAARSGT*RSGQLVLSIVGCIPA APTVLLARLAAARTSP*ALLMKALPGWCWHPRTW **RGMRRPCSIASSQPSHPRACSGSLRMRLPSL TAVAPHTSAEPQCLPTGLCC*PRSGHAMQGSTA ALARGRGAHPSSWKPHFT*QRLKTCRYLSHGCLQ LAARSV*PAFPPRVCQSPACGGSTRESGCPPMA GSTRRATSWCWPILLKVMLVSTPATRPTWLVSG DRMSTSLWPLCPPG*RSPKTASWRRANPATWIA* PRPHQNLQLSGTETRCSSQRTHGSRSSRMGPCA STAWRCMMGHGTVV*AAPQPAASRRKPVSKCWK SSSSHHHPSHSSAWSLTRRPRCPVQPQAERSPLL SGNGQMGAASQSG*QTTLGPCILPG*LEMTLAT TLALPPTGRRARFVPMSSSLWQFLSPSKWNQSV RLCTRATQPYCSARPRGTPSR*FSGKARTASWTP PSWDPGCTSSRMAPW*SMTWPLRTQAATPALQA TAATSSTRRPPSMSWTSLCRRSRRALAALPPTR *SRPLGCRWVPLWPTSLPCWASCSTARSAAKPSG CRSSPRARSQRWNASTVGLCRTGSPQQRSKKKW P*PAWAPAPRPPTNATAQVIRCTSHGLACSPSP RWGRVSLGRCSWQRLRAWRREWQRPWYL*RACRA RMSSSSWTSGGSWRCLGS*TTPTWCGSWGCAGR LSPTTWCWNMWIWETSSSS*GFPRARMKN*SHS PSAPSRRWPYAPR*PWAWSTCPTTALCIRTWLRV TAWSVPRDK*RCLPWASARMCTTVSTTTSARPG CRCAGCPPRPSWRVTSLPSLMSGPSVC*CGKCL HMERCPMVGRQMMKYWQICRLGRLDFLSPRAALP NSIG*CSAAGPSAPRTGPPSVRLPAPWETAPWT ASREEGARSGWPGQGRTSLEGSSQHDGQDPCPP GP*GPCPSATGIAEV*AGPGLSSSSSPSSFGRLT WTQTGRLGL*AGQFSLPPLPLSGTVWVPQVTPI SGLQLLPLTGSNSATHLPTLPGEG*AWDELGLW GVP*YSQVLGTQG**VSWPTGPTWGSRPGL*RTQ QVSPPHSGLVHTDPDPRLPHPSLLSSS*VPGR* RSFQELLTLYKPPFLYAPRAAFICNCSVGWVGM GGRGGPWR*GGWAILTPHFYCCRFLFVLFFCFCF CFYTRCSQ*ISLFYNL

Frame 2

GARGLGGTGRARLRLGTPRDASGSGSGCGCCCG ARAPVRSASCARRGAQSARPPCALSSFS*ARRD GSCAGIPGQTPPVASAQRPAAAAAGRYPDSHCL HQAAVLPGCTAGAPGAASL*G*GSGPGTCVLAAR WGPCPGHGAAFRPGQQPELCSCGPAAGLWHLPV CGSG*CHWRRSPQCQRLLQHQMD*GRSCGPEAS SLGS*DPATDPGHTSLPH*WAPSAHLPMVPRWDP PF*WSEQPHSQQQGAEPDAPASWS*A*WAVFLL RPQCFWPGLQQPELHLEHC**KLCQGGAGTPGR GSSEV*GGHVPLPVLSPATPEPAVAL*G*DSHH* PQSPPTPPQSHSVCQRVSAADPGPATQCRDLPL HWPGAEGPTHHPGSHTSPSRD*RHAAI*ATGVY SWQRGACDLPSPQGSARAQRVVGARGSPAAHPWQ GLPEGPRAGVGQYC*K*CWCLHLPRGQPGWSAE TGCQHHCGHCALLAEEAPRQPAGGGQTRLLGLP DPGHTKTYSCLVQKPDAHLRGLTVRGLQEWDLAH QQRGGV*WDMVPLYEQHPSRQHRGASPCPSAGK AQVHTTTPATAVHGV*QGGHGALFSHRPREAHY *VGTGRWEQPPRVGDRQRWDPAFCPGDSR*RWQL HLHCLQRAAGPDSCPCPAHCGSFYHLQSGTRAY DCVPGPHSPTAVRGPGGPQAADSVERQGPHPGP HQAGTQDAHLPEWLPGDP*RGP*GLRPLHLHCRQ QLQHQAHGGPPLCRGQACAGGVGGPWQPSPLQD DPDHWVVGGCRCGLHHCRAGPHVLLQEALQSQA AAEAARGRGARDGMPQRWAFAERAALSRDPRRSG LDQLGLRPRGHQQTPQHK**DALPTV*PAAHHH AGEE*VWGGVPGKGSGLGGGSGRDPGTCEEPAE QG*AAAAGLPEGVGDVWEAEPRQRGAAPGAVPGG *APLHGAGICGSGRPQAVPEDFQEQG*KIEVTA PQHQAEGGPMHPGSPGHGAPVQQPLCA*GLGCA *LPGQCPETSEGVCPGPQQGCVQQ*VLPLPPGLG AAALDVPRGHPGG*LLYQV*CLGLRCADVGSVY TWRDAPWWAGR**STGRFAGWEG*TSSARGLPF QTLSADAALLGPQPQGPALLQ*DCQRPGRQHRGQ QAVRREPAQDGLGRGGHL*REAHSMMGKIPVLL GPEAPALVQQALLRSEQGLAFPPLPHPHPLGG* LGPKLGD*GFELGSFPCHLFLYQGQCGCHR*PQF LAFNFSP*PGPTLPLICQLCLGRARLGMSWVCG EFLNILKFWAHRVNESLGPLVPLGGLDQDYRGH SK*VLPTLGLCTLTQTHVFPTLLSFPHPKCLADE GVFRSF*HYINRPFCMHHGRLLYVIAAWGGWAW EVGVGPGDEEGGPSLPHTFIVVVFCLFCFFVFV FVFTLAALNK*AFFTT

Sequence NM_152882

GCGGCGCGCGGGGACTCGGAGGTACTGGGCGCGCGCGGCTCCGGCTCGGGACGCCTCGGGACGCCTCGGGGTCGGGCTCCGGCTGCGGCTGCTGCTGCGG CGCCCGCGCTCCGGTGCGCTCCGCCTCCTGTGCCCGCCGCGGAGCGCAGTCTGCGCGCCCGCCGTGCGCCCTCAGCTCCTTTTCCTGAGCCCGCCGCGAT GGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTGCTGCTGCCGCTGCTGGGCGGTACCCAGACAGCCATTGTCTTC ATCAAGCAGCCGTCCTCCCAGGATGCACTGCAGGGGCGCCGGGCGCTGCTTCGCTGTGAGGTTGAGGCTCCGGGCCCGGTACATGTGTACTGGCTGCTCG ATGGGGCCCCTGTCCAGGACACGGAGCGGCGTTTCGCCCAGGGCAGCAGCCTGAGCTTTGCAGCTGTGGACCGGCTGCAGGACTCTGGCACCTTCCAGTG TGTGGCTCGGGATGATGTCACTGGAGAAGAAGCCCGCAGTGCCAACGCCTCCTTCAACATCAAATGGATTGAGGCAGGTCCTGTGGTCCTGAAGCATCCA GCCTCGGAAGCTGAGATCCAGCCACAGACCCAGGTCACACTTCGTTGCCACATTGATGGGCACCCTCGGCCCACCTACCAATGGTTCCGAGATGGGACCC CCCTTTCTGATGGTCAGAGCAACCACACAGTCAGCAGCAAGGAGCGGAACCTGACGCTCCGGCCAGCTGGTCCTGAGCATAGTGGGCTGTATTCCTGCTG CGCCCACAGTGCTTTTGGCCAGGCTTGCAGCAGCCAGAACTTCACCTTGAGCATTGCTGATGAAAGCTTTGCCAGGGTGGTGCTGGCACCCCAGGACGTG GTAGTAGCGAGGTATGAGGAGGCCATGTTCCATTGCCAGTTCTCAGCCCAGCCACCCCCGAGCCTGCAGTGGCTCTTTGAGGATGAGACTCCCATCACTA ACCGCAGTCGCCCCCCACACCTCCGCAGAGCCACAGTGTTTGCCAACGGGTCTCTGCTGCTGACCCAGGTCCGGCCACGCAATGCAGGGATCTACCGCTG CATTGGCCAGGGGCAGAGGGGCCCACCCATCATCCTGGAAGCCACACTTCACCTAGCAGAGATTGAAGACATGCCGCTATTTGAGCCACGGGTGTTTACA GCTGGCAGCGAGGAGCGTGTGACCTGCCTTCCCCCCAAGGGTCTGCCAGAGCCCAGCGTGTGGTGGGAGCACGCGGGAGTCCGGCTGCCCACCCATGGCA GGGTCTACCAGAAGGGCCACGAGCTGGTGTTGGCCAATATTGCTGAAAGTGATGCTGGTGTCTACACCTGCCACGCGGCCAACCTGGCTGGTCAGCGGAG ACAGGATGTCAACATCACTGTGGCCACTGTGCCCTCCTGGCTGAAGAAGCCCCAAGACAGCCAGCTGGAGGAGGGCAAACCCGGCTACTTGGATTGCCTG ACCCAGGCCACACCAAAACCTACAGTTGTCTGGTACAGAAACCAGATGCTCATCTCAGAGGACTCACGGTTCGAGGTCTTCAAGAATGGGACCTTGCGCA TCAACAGCGTGGAGGTGTATGATGGGACATGGTACCGTTGTATGAGCAGCACCCCAGCCGGCAGCATCGAGGCGCAAGCCCGTGTCCAAGTGCTGGAAAA GCTCAAGTTCACACCACCACCCCAGCCACAGCAGTGCATGGAGTTTGACAAGGAGGCCACGGTGCCCTGTTCAGCCACAGGCCGAGAGAAGCCCACTATT AAGTGGGAACGGGCAGATGGGAGCAGCCTCCCAGAGTGGGTGACAGACAACGCTGGGACCCTGCATTTTGCCCGGGTGACTCGAGATGACGCTGGCAACT ACACTTGCATTGCCTCCAACGGGCCGCAGGGCCAGATTCGTGCCCATGTCCAGCTCACTGTGGCAGTTTTTATCACCTTCAAAGTGGAACCAGAGCGTAC GACTGTGTACCAGGGCCACACAGCCCTACTGCAGTGCGAGGCCCAGGGGGACCCCAAGCCGCTGATTCAGTGGAAAGACAAGCCTGTGCCGGAGGAGTCG GAGGGCCCTGGCAGCCCTCCCCCCTACAAGATGATCCAGACCATTGGGTTGTCGGTGGGTGCCGCTGTGGCCTACATCATTGCCGTGCTGGGCCTCATGT TCTACTGCAAGAAGCGCTGCAAAGCCAAGCGGCTGCAGAAGCAGCCCGAGGGCGAGGAGCCAGAGATGGAATGCCTCAACGGTGGGCCTTTGCAGAACGG GCAGCCCTCAGCAGAGATCCAAGAAGAAGTGGCCTTGACCAGCTTGGGCTCCGGCCCCGCGGCCACCAACAAACGCCACAGCACAAGTGATAAGATGCAC TTCCCACGGTCTAGCCTGCAGCCCATCACCACGCTGGGGAAGAGTGAGTTTGGGGAGGTGTTCCTGGCAAAGGCTCAGGGCTTGGAGGAGGGAGTGGCAG AGACCCTGGTACTTGTGAAGAGCCTGCAGAGCAAGGATGAGCAGCAGCAGCTGGACTTCCGGAGGGAGTTGGAGATGTTTGGGAAGCTGAACCACGCCAA CGTGGTGCGGCTCCTGGGGCTGTGCCGGGAGGCTGAGCCCCACTACATGGTGCTGGAATATGTGGATCTGGGAGACCTCAAGCAGTTCCTGAGGATTTCC AAGAGCAAGGATGAAAAATTGAAGTCACAGCCCCTCAGCACCAAGCAGAAGGTGGCCCTATGCACCCAGGTAGCCCTGGGCATGGAGCACCTGTCCAACA ACCGCTTTGTGCATAAGGACTTGGCTGCGCGTAACTGCCTGGTCAGTGCCCAGAGACAAGTGAAGGTGTCTGCCCTGGGCCTCAGCAAGGATGTGTACAA CAGTGAGTACTACCACTTCCGCCAGGCCTGGGTGCCGCTGCGCTGGATGTCCCCCGAGGCCATCCTGGAGGGTGACTTCTCTACCAAGTCTGATGTCTGG GCCTTCGGTGTGCTGATGTGGGAAGTGTTTACACATGGAGAGATGCCCCATGGTGGGCAGGCAGATGATGAAGTACTGGCAGATTTGCAGGCTGGGAAGG CTAGACTTCCTCAGCCCGAGGGCTGCCCTTCCAAACTCTATCGGCTGATGCAGCGCTGCTGGGCCCTCAGCCCCAAGGACCGGCCCTCCTTCAGTGAGAT TGCCAGCGCCCTGGGAGACAGCACCGTGGACAGCAAGCCGTGAGGAGGGAGCCCGCTCAGGATGGCCTGGGCAGGGGAGGACATCTCTAGAGGGAAGCTC ACAGCATGATGGGCAAGATCCCTGTCCTCCTGGGCCCTGAGGCCCCTGCCCTAGTGCAACAGGCATTGCTGAGGTCTGAGCAGGGCCTGGCCTTTCCTCC TCTTCCTCACCCTCATCCTTTGGGAGGCTGACTTGGACCCAAACTGGGCGACTAGGGCTTTGAGCTGGGCAGTTTTCCCTGCCACCTCTTCCTCTATCAG GGACAGTGTGGGTGCCACAGGTAACCCCAATTTCTGGCCTTCAACTTCTCCCCTTGACCGGGTCCAACTCTGCCACTCATCTGCCAACTTTGCCTGGGGA GGGCTAGGCTTGGGATGAGCTGGGTTTGTGGGGAGTTCCTTAATATTCTCAAGTTCTGGGCACACAGGGTTAATGAGTCTCTTGGCCCACTGGTCCCACT TGGGGGTCTAGACCAGGATTATAGAGGACACAGCAAGTGAGTCCTCCCCACTCTGGGCTTGTGCACACTGACCCAGACCCACGTCTTCCCCACCCTTCTC TCCTTTCCTCATCCTAAGTGCCTGGCAGATGAAGGAGTTTTCAGGAGCTTTTGACACTATATAAACCGCCCTTTTTGTATGCACCACGGGCGGCTTTTAT ATGTAATTGCAGCGTGGGGTGGGTGGGCATGGGAGGTAGGGGTGGGCCCTGGAGATGAGGAGGGTGGGCCATCCTTACCCCACACTTTTATTGTTGTCGT TTTTTGTTTGTTTTGTTTTTTTGTTTTTGTTTTTGTTTTTACACTCGCTGCTCTCAATAAATAAGCCTTTTTTACAACCTG

refseq_PTK7.F1 (forward primer)
refseq_PTK7.R1 (reverse primer)
Single exon skipping

Frame 0

AARGDSEVLGARGSGSGRLGTPRGRAPAAAAAA APALRCAPPPVPAAERSLRARRAPSAPFPEPAAM GAARGSPARPRRLPLLSVLLLPLLGGTQTAIVF IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLL DGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQC VARDDVTGEEARSANASFNIKWIEAGPVVLKHP ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGT PLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCC AHSAFGQACSSQNFTLSIADESFARVVLAPQDV VVARYEEAMFHCQFSAQPPPSLQWLFEDETPIT NRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRC IGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT AGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHG RVYQKGHELVLANIAESDAGVYTCHAANLAGQRR QDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL TQATPKPTVVWYRNQMLISEDSRFEVFKNGTLR INSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEK LKFTPPPQPQQCMEFDKEATVPCSATGREKPTI KWERADGSSLPEWVTDNAGTLHFARVTRDDAGN YTCIASNGPQGQIRAHVQLTVAVFITFKVEPERT TVYQGHTALLQCEAQGDPKPLIQWKDKPVPEES EGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLM FYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNG QPSAEIQEEVALTSLGSGPAATNKRHSTSDKMH FPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVA ETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHAN VVRLLGLCREAEPHYMVLEYVDLGDLKQFLRIS KSKDEKLKSQPLSTKQKVALCTQVALGMEHLSN NRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYN SEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVW AFGVLMWEVFTHGEMPHGGQADDEVLADLQAGK ARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI ASALGDSTVDSKP*GGSPLRMAWAGEDISRGKL TA*WARSLSSWALRPLP*CNRHC*GLSRAWPFL LFLTLILWEADLDPNWATRALSWAVFPATSSSIR DSVGATGNPNFWPSTSPLDRVQLCHSSANFAWG GLGLG*AGFVGSSLIFSSSGHTGLMSLLAHWSH LGV*TRIIEDTASESSPLWACAH*PRPTSSPPFS PFLILSAWQMKEFSGAFDTI*TALFVCTTGGFY M*LQRGVGGHGR*GWALEMRRVGHPYPTLLLLS FFVCFVFLFLFLFLHSLLSINKPFLQP

Frame 1

RRAGTRRYWARAAPARDASGRLGVGLRLRLLLR RPRSGALRLLCPPRSAVCAPAVRPQLLFLSPPR WELRGDPRPDPAGCLCSASCCCRCWAVPRQPLSS SSSRPPRMHCRGAGRCFAVRLRLRARYMCTGCS MGPLSRTRSGVSPRAAA*ALQLWTGCRTLAPSS VWLGMMSLEKKPAVPTPPSTSNGLRQVLWS*SIQ PRKLRSSHRPRSHFVATLMGTLGPPTNGSEMGP PFLMVRATTQSAARSGT*RSGQLVLSIVGCIPA APTVLLARLAAARTSP*ALLMKALPGWCWHPRTW **RGMRRPCSIASSQPSHPRACSGSLRMRLPSL TAVAPHTSAEPQCLPTGLCC*PRSGHAMQGSTA ALARGRGAHPSSWKPHFT*QRLKTCRYLSHGCLQ LAARSV*PAFPPRVCQSPACGGSTRESGCPPMA GSTRRATSWCWPILLKVMLVSTPATRPTWLVSG DRMSTSLWPLCPPG*RSPKTASWRRANPATWIA* PRPHQNLQLSGTETRCSSQRTHGSRSSRMGPCA STAWRCMMGHGTVV*AAPQPAASRRKPVSKCWK SSSSHHHPSHSSAWSLTRRPRCPVQPQAERSPLL SGNGQMGAASQSG*QTTLGPCILPG*LEMTLAT TLALPPTGRRARFVPMSSSLWQFLSPSKWNQSV RLCTRATQPYCSARPRGTPSR*FSGKTSLCRRSR RALAALPPTR*SRPLGCRWVPLWPTSLPCWASC STARSAAKPSGCRSSPRARSQRWNASTVGLCRT GSPQQRSKKKWP*PAWAPAPRPPTNATAQVIRCT SHGLACSPSPRWGRVSLGRCSWQRLRAWRREWQ RPWYL*RACRARMSSSSWTSGGSWRCLGS*TTP TWCGSWGCAGRLSPTTWCWNMWIWETSSSS*GFP RARMKN*SHSPSAPSRRWPYAPR*PWAWSTCPT TALCIRTWLRVTAWSVPRDK*RCLPWASARMCT TVSTTTSARPGCRCAGCPPRPSWRVTSLPSLMSG PSVC*CGKCLHMERCPMVGRQMMKYWQICRLGR LDFLSPRAALPNSIG*CSAAGPSAPRTGPPSVR LPAPWETAPWTASREEGARSGWPGQGRTSLEGSS QHDGQDPCPPGP*GPCPSATGIAEV*AGPGLSS SSSPSSFGRLTWTQTGRLGL*AGQFSLPPLPLS GTVWVPQVTPISGLQLLPLTGSNSATHLPTLPGE G*AWDELGLWGVP*YSQVLGTQG**VSWPTGPT WGSRPGL*RTQQVSPPHSGLVHTDPDPRLPHPS LLSSS*VPGR*RSFQELLTLYKPPFLYAPRAAFI CNCSVGWVGMGGRGGPWR*GGWAILTPHFYCCR FLFVLFFCFCFCFYTRCSQ*ISLFYNL

Frame 2

GARGLGGTGRARLRLGTPRDASGSGSGCGCCCG ARAPVRSASCARRGAQSARPPCALSSFS*ARRD GSCAGIPGQTPPVASAQRPAAAAAGRYPDSHCL HQAAVLPGCTAGAPGAASL*G*GSGPGTCVLAAR WGPCPGHGAAFRPGQQPELCSCGPAAGLWHLPV CGSG*CHWRRSPQCQRLLQHQMD*GRSCGPEAS SLGS*DPATDPGHTSLPH*WAPSAHLPMVPRWDP PF*WSEQPHSQQQGAEPDAPASWS*A*WAVFLL RPQCFWPGLQQPELHLEHC**KLCQGGAGTPGR GSSEV*GGHVPLPVLSPATPEPAVAL*G*DSHH* PQSPPTPPQSHSVCQRVSAADPGPATQCRDLPL HWPGAEGPTHHPGSHTSPSRD*RHAAI*ATGVY SWQRGACDLPSPQGSARAQRVVGARGSPAAHPWQ GLPEGPRAGVGQYC*K*CWCLHLPRGQPGWSAE TGCQHHCGHCALLAEEAPRQPAGGGQTRLLGLP DPGHTKTYSCLVQKPDAHLRGLTVRGLQEWDLAH QQRGGV*WDMVPLYEQHPSRQHRGASPCPSAGK AQVHTTTPATAVHGV*QGGHGALFSHRPREAHY *VGTGRWEQPPRVGDRQRWDPAFCPGDSR*RWQL HLHCLQRAAGPDSCPCPAHCGSFYHLQSGTRAY DCVPGPHSPTAVRGPGGPQAADSVERQACAGGV GGPWQPSPLQDDPDHWVVGGCRCGLHHCRAGPHV LLQEALQSQAAAEAARGRGARDGMPQRWAFAER AALSRDPRRSGLDQLGLRPRGHQQTPQHK**DA LPTV*PAAHHHAGEE*VWGGVPGKGSGLGGGSGR DPGTCEEPAEQG*AAAAGLPEGVGDVWEAEPRQ RGAAPGAVPGG*APLHGAGICGSGRPQAVPEDF QEQG*KIEVTAPQHQAEGGPMHPGSPGHGAPVQQ PLCA*GLGCA*LPGQCPETSEGVCPGPQQGCVQ Q*VLPLPPGLGAAALDVPRGHPGG*LLYQV*CL GLRCADVGSVYTWRDAPWWAGR**STGRFAGWEG *TSSARGLPFQTLSADAALLGPQPQGPALLQ*D CQRPGRQHRGQQAVRREPAQDGLGRGGHL*REA HSMMGKIPVLLGPEAPALVQQALLRSEQGLAFPP LPHPHPLGG*LGPKLGD*GFELGSFPCHLFLYQ GQCGCHR*PQFLAFNFSP*PGPTLPLICQLCLG RARLGMSWVCGEFLNILKFWAHRVNESLGPLVPL GGLDQDYRGHSK*VLPTLGLCTLTQTHVFPTLL SFPHPKCLADEGVFRSF*HYINRPFCMHHGRLL YVIAAWGGWAWEVGVGPGDEEGGPSLPHTFIVVV FCLFCFFVFVFVFTLAALNK*AFFTT