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Sequences

Sequence NM_173175

ATCTAACCTGTCAGCCCTTTTACTCAGCCACAGCCTCCGGAGCCGTTGCACACCTACCTGCCCGGCCGACTTACCTGTACTTGCCGCCGTCCCGGCTCAC
CTGGCGGTGCCCGAGGAGTAGTCGCTGGAGTCCGCGCCTCCCTGGGACTGCAATGTGCCGATCTTAGCTGCTGCCTGAGAGGATGTCTGGGGTGTCCGAG
CCCCTGAGTCGAGTAAAGTTGGGCACGTTACGCCGGCCTGAAGGCCCTGCAGAGCCCATGGTGGTGGTACCAGTAGATGTGGAAAAGGAGGACGTGCGTA
TCCTCAAGGTCTGCTTCTATAGCAACAGCTTCAATCCTGGGAAAAACTTCAAACTGGTCAAATGCACTGTCCAGACGGAGATCCGGGAGATCATCACCTC
CATCCTGCTGAGCGGGCGGATCGGGCCCAACATCCGGTTGGCTGAGTGCTATGGGCTGAGGCTGAAGCACATGAAGTCCGATGAGATCCACTGGCTGCAC
CCACAGATGACGGTGGGTGAGGTGCAGGACAAGTATGAGTGTCTGCACGTGGAAGCCGAGTGGAGGTATGACCTTCAAATCCGCTACTTGCCAGAAGACT
TCATGGAGAGCCTGAAGGAGGACAGGACCACGCTGCTCTATTTTTACCAACAGCTCCGGAACGACTACATGCAGCGCTACGCCAGCAAGGTCAGCGAGGG
CATGGCCCTGCAGCTGGGCTGCCTGGAGCTCAGGCGGTTCTTCAAGGATATGCCCCACAATGCACTTGACAAGAAGTCCAACTTCGAGCTCCTAGAAAAG
GAAGTGGGGCTGGACTTGTTTTTCCCAAAGCAGATGCAGGAGAACTTAAAGCCCAAACAGTTCCGGAAGATGATCCAGCAGACCTTCCAGCAGTACGCCT
CGCTCAGGGAGGAGGAGTGCGTCATGAAGTTCTTCAACACTCTCGCCGGCTTCGCCAACATCGACCAGGAGACCTACCGCTGTGAACTCATTCAAGGATG
GAACATTACTGTGGACCTGGTCATTGGCCCTAAAGGGATCCGCCAGCTGACTAGTCAGGACGCAAAGCCCACCTGCCTGGCCGAGTTCAAGCAGATCAGG
TCCATCAGGTGCCTCCCGCTGGAGGAGGGCCAGGCAGTACTTCAGCTGGGCATTGAAGGTGCCCCCCAGGCCTTGTCCATCAAAACCTCATCCCTAGCAG
AGGCTGAGAACATGGCTGACCTCATAGACGGCTACTGCCGGCTGCAGGGTGAGCACCAAGGCTCTCTCATCATCCATCCTAGGAAAGATGGTGAGAAGCG
GAACAGCCTGCCCCAGATCCCCATGCTAAACCTGGAGGCCCGGCGGTCCCACCTCTCAGAGAGCTGCAGCATAGAGTCAGACATCTACGCAGAGATTCCC
GACGAAACCCTGCGAAGGCCCGGAGGTCCACAGTATGGCATTGCCCGTGAAGATGTGGTCCTGAATCGTATTCTTGGGGAAGGCTTTTTTGGGGAGGTCT
ATGAAGGTGTCTACACAAATCACAAAGGGGAGAAAATCAATGTAGCTGTCAAGACCTGCAAGAAAGACTGCACTCTGGACAACAAGGAGAAGTTCATGAG
CGAGGCAGTGATCATGAAGAACCTCGACCACCCGCACATCGTGAAGCTGATCGGCATCATTGAAGAGGAGCCCACCTGGATCATCATGGAATTGTATCCC
TATGGGGAGCTGGGCCACTACCTGGAGCGGAACAAGAACTCCCTGAAGGTGCTCACCCTCGTGCTGTACTCACTGCAGATATGCAAAGCCATGGCCTACC
TGGAGAGCATCAACTGCGTGCACAGGGACATTGCTGTCCGGAACATCCTGGTGGCCTCCCCTGAGTGTGTGAAGCTGGGGGACTTTGGTCTTTCCCGGTA
CATTGAGGACGAGGACTATTACAAAGCCTCTGTGACTCGTCTCCCCATCAAATGGATGTCCCCAGAGTCCATTAACTTCCGACGCTTCACGACAGCCAGT
GACGTCTGGATGTTCGCCGTGTGCATGTGGGAGATCCTGAGCTTTGGGAAGCAGCCCTTCTTCTGGCTGGAGAACAAGGATGTCATCGGGGTGCTGGAGA
AAGGAGACCGGCTGCCCAAGCCTGATCTCTGTCCACCGGTCCTTTATACCCTCATGACCCGCTGCTGGGACTACGACCCCAGTGACCGGCCCCGCTTCAC
CGAGCTGGTGTGCAGCCTCAGTGACGTTTATCAGATGGAGAAGGACATTGCCATGGAGCAAGAGAGGAATGCTCGCTACCGAACCCCCAAAATCTTGGAG
CCCACAGCCTTCCAGGAACCCCCACCCAAGCCCAGCCGACCTAAGTACAGACCCCCTCCGCAAACCAACCTCCTGGCTCCAAAGCTGCAGTTCCAGGAGG
AGGACTTCATCCAACCCAGCAGCCGAGAAGAGGCCCAGCAGCTGTGGGAGGCTGAAAAGGTCAAAATGCGGCAAATCCTGGACAAACAGCAGAAGCAGAT
GGTGGAGGACTACCAGTGGCTCAGGCAGGAGGAGAAGTCCCTGGACCCCATGGTTTATATGAATGATAAGTCCCCATTGACGCCAGAGAAGGAGGTCGGC
TACCTGGAGTTCACAGGGCCCCCACAGAAGCCCCCGAGGCTGGGCGCACAGTCCATCCAGCCCACAGCTAACCTGGACCGGACTGATGACCTGGTGTACC
TCAATGTCATGGAGCTGGTGCGGGCCGTGCTGGAGCTCAAGAATGAGCTCTGTCAGCTGCCCCCCGAGGGCTACGTGGTGGTGGTGAAGAATGTGGGGCT
GACCCTGCGGAAGCTCATCGGGAGCGTGGATGATCTCCTGCCTTCCTTGCCGTCATCTTCACGGACAGAGATCGAGGGCACCCAGAAACTGCTCAACAAA
GACCTGGCAGAGCTCATCAACAAGATGCGGCTGGCACAGCAGAACGCCGTGACCTCCCTAAGTGAGGAGTGCAAGAGGCAGATGCTGACGGCTTCACACA
CCCTGGCTGTGGACGCCAAGAACCTGCTCGACGCTGTGGACCAGGCCAAGGTTCTGGCCAATCTGGCCCACCCACCTGCAGAGTGACGGAGGGTGGGGGC
CACCTGCCTGCGTCTTCCGCCCCTGCCTGCCATGTACCTCCCCTGCCTTGCTGTTGGTCATGTGGGTCTTCCAGGGGGAAGGCCAAGGGGAGTCACCTTC
CCTTGCCACTTTGCACGACGCCCTCTCCCCACCCCTACCCCTGGCTGTACTGCTCAGGCTGCAGCTGGACAGAGGGGACTCTGGGCTATGGACACAGGGT
GACGGTGACAAAGATGGCTCAGAGGGGGACTGCTGCTGCCTGGCCACTGCTCCCTAAGCCAGCCTGGTCCATGCAGGGGGCTCCTGGGGGTGGGGAGGTG
TCACATGGTGCCCCTAGCTTTATATATGGACATGGCAGGCCGATTTGGGAACCAAGCTATTCCTTTCCCTTCCTCTTCGGCCCTCAGATGTCCCTTGATG
CACAGAGAAGCTGGGGAGGAGCTTTGTTTTGGGGGTCAGGCAGCCAGTGAGATGAGGGATGGGCCTGGCATTCTTGTACAGTGTATATTGAAATTTATTT
AATGTGAGTTTGGTCTGGACTGACAGCATGTGCCCTCCTGAGGGAGGACCTGGGGCACAGTCCAGGAACAAGCTAATTGGGAGTCCAGGCACAGGATGCT
GTGTTGTCAACAAACCAAGCATCAGGGGGAAGAAGCAGAGAGATGCGGCCAAGATAGGACCTTGGGCCAAATCCGCTCTCTTCCTGCCCCTCTTTCTCTT
TCTTCCTTTACTTTCCCTTGCTTTTCCCTCTTTTCTTACTCCTCCTCTTTCTCTCCCCAACCCCCATTCTCATCTGCACCCTTCTTTTCTCATGTGTTTG
CATAAACATTCTTTTAACTTCTTTCTATTTGACTTGTGGTTGAATTAAAATTGTCCCATTTGC
  • refseq_PTK2B.F1 (forward primer)
  • refseq_PTK2B.R1 (reverse primer)
  • Single exon skipping

Frame 0

I*PVSPFTQPQPPEPLHTYLPGRLTCTCRRPGS
PGGARGVVAGVRASLGLQCADLSCCLRGCLGCPS
P*VE*SWARYAGLKALQSPWWWYQ*MWKRRTCV
SSRSASIATASILGKTSNWSNALSRRRSGRSSP
PSC*AGGSGPTSGWLSAMG*G*ST*SPMRSTGCT
HR*RWVRCRTSMSVCTWKPSGGMTFKSATCQKT
SWRA*RRTGPRCSIFTNSSGTTTCSATPARSAR
AWPCSWAAWSSGGSSRICPTMHLTRSPTSSS*KR
KWGWTCFSQSRCRRT*SPNSSGR*SSRPSSSTP
RSGRRSAS*SSSTLSPASPTSTRRPTAVNSFKD
GTLLWTWSLALKGSAS*LVRTQSPPAWPSSSRSG
PSGASRWRRARQYFSWALKVPPRPCPSKPHP*Q
RLRTWLTS*TATAGCRVSTKALSSSILGKMVRS
GTACPRSPC*TWRPGGPTSQRAAA*SQTSTQRFP
TKPCEGPEVHSMALPVKMWS*IVFLGKAFLGRS
MKVSTQITKGRKSM*LSRPARKTALWTTRRSS*
ARQ*S*RTSTTRTS*S*SASLKRSPPGSSWNCIP
MGSWATTWSGTRTP*RCSPSCCTHCRYAKPWPT
WRASTACTGTLLSGTSWWPPLSV*SWGTLVFPG
TLRTRTITKPL*LVSPSNGCPQSPLTSDASRQPV
TSGCSPCACGRS*ALGSSPSSGWRTRMSSGCWR
KETGCPSLISVHRSFIPS*PAAGTTTPVTGPAS
PSWCAASVTFIRWRRTLPWSKRGMLATEPPKSWS
PQPSRNPHPSPADLSTDPLRKPTSWLQSCSSRR
RTSSNPAAEKRPSSCGRLKRSKCGKSWTNSRSR
WWRTTSGSGRRRSPWTPWFI*MISPH*RQRRRSA
TWSSQGPHRSPRGWAHSPSSPQLTWTGLMTWCT
SMSWSWCGPCWSSRMSSVSCPPRATWWW*RMWG
*PCGSSSGAWMISCLPCRHLHGQRSRAPRNCSTK
TWQSSSTRCGWHSRTP*PP*VRSARGRC*RLHT
PWLWTPRTCSTLWTRPRFWPIWPTHLQSDGGWG
PPACVFRPCLPCTSPALLLVMWVFQGEGQGESPS
LATLHDALSPPLPLAVLLRLQLDRGDSGLWTQG
DGDKDGSEGDCCCLATAP*ASLVHAGGSWGWGG
VTWCP*LYIWTWQADLGTKLFLSLPLRPSDVP*C
TEKLGRSFVLGVRQPVR*GMGLAFLYSVY*NLF
NVSLVWTDSMCPPEGGPGAQSRNKLIGSPGTGC
CVVNKPSIRGKKQRDAAKIGPWAKSALFLPLFLF
LPLLSLAFPSFLTPPLSLPNPHSHLHPSFLMCL
HKHSFNFFLFDLWLN*NCPIC

Frame 1

SNLSALLLSHSLRSRCTPTCPADLPVLAAVPAH
LAVPEE*SLESAPPWDCNVPILAAA*EDVWGVR
APESSKVGHVTPA*RPCRAHGGGTSRCGKGGRAY
PQGLLL*QQLQSWEKLQTGQMHCPDGDPGDHHL
HPAERADRAQHPVG*VLWAEAEAHEVR*DPLAA
PTDDGG*GAGQV*VSARGSRVEV*PSNPLLARRL
HGEPEGGQDHAALFLPTAPERLHAALRQQGQRG
HGPAAGLPGAQAVLQGYAPQCT*QEVQLRAPRK
GSGAGLVFPKADAGELKAQTVPEDDPADLPAVRL
AQGGGVRHEVLQHSRRLRQHRPGDLPL*THSRM
EHYCGPGHWP*RDPPAD*SGRKAHLPGRVQADQ
VHQVPPAGGGPGSTSAGH*RCPPGLVHQNLIPSR
G*EHG*PHRRLLPAAG*APRLSHHPS*ERW*EA
EQPAPDPHAKPGGPAVPPLRELQHRVRHLRRDS
RRNPAKARRSTVWHCP*RCGPESYSWGRLFWGGL
*RCLHKSQRGENQCSCQDLQERLHSGQQGEVHE
RGSDHEEPRPPAHREADRHH*RGAHLDHHGIVS
LWGAGPLPGAEQELPEGAHPRAVLTADMQSHGLP
GEHQLRAQGHCCPEHPGGLP*VCEAGGLWSFPV
H*GRGLLQSLCDSSPHQMDVPRVH*LPTLHDSQ
*RLDVRRVHVGDPELWEAALLLAGEQGCHRGAGE
RRPAAQA*SLSTGPLYPHDPLLGLRPQ*PAPLH
RAGVQPQ*RLSDGEGHCHGAREECSLPNPQNLG
AHSLPGTPTQAQPT*VQTPSANQPPGSKAAVPGG
GLHPTQQPRRGPAAVGG*KGQNAANPGQTAEAD
GGGLPVAQAGGEVPGPHGLYE**VPIDAREGGR
LPGVHRAPTEAPEAGRTVHPAHS*PGPD**PGVP
QCHGAGAGRAGAQE*ALSAAPRGLRGGGEECGA
DPAEAHRERG*SPAFLAVIFTDRDRGHPETAQQ
RPGRAHQQDAAGTAERRDLPK*GVQEADADGFTH
PGCGRQEPARRCGPGQGSGQSGPPTCRVTEGGG
HLPASSAPACHVPPLPCCWSCGSSRGKAKGSHL
PLPLCTTPSPHPYPWLYCSGCSWTEGTLGYGHRV
TVTKMAQRGTAAAWPLLPKPAWSMQGAPGGGEV
SHGAPSFIYGHGRPIWEPSYSFPFLFGPQMSLD
AQRSWGGALFWGSGSQ*DEGWAWHSCTVYIEIYL
M*VWSGLTACALLREDLGHSPGTS*LGVQAQDA
VLSTNQASGGRSREMRPR*DLGPNPLSSCPSFS
FFLYFPLLFPLFLLLLFLSPTPILICTLLFSCVC
INILLTSFYLTCG*IKIVPF

Frame 2

LTCQPFYSATASGAVAHLPARPTYLYLPPSRLT
WRCPRSSRWSPRLPGTAMCRS*LLPERMSGVSE
PLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVR
ILKVCFYSNSFNPGKNFKLVKCTVQTEIREIITS
ILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLH
PQMTVGEVQDKYECLHVEAEWRYDLQIRYLPED
FMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEG
MALQLGCLELRRFFKDMPHNALDKKSNFELLEK
EVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYA
SLREEECVMKFFNTLAGFANIDQETYRCELIQGW
NITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIR
SIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLA
EAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKR
NSLPQIPMLNLEARRSHLSESCSIESDIYAEIP
DETLRRPGGPQYGIAREDVVLNRILGEGFFGEV
YEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMS
EAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYP
YGELGHYLERNKNSLKVLTLVLYSLQICKAMAY
LESINCVHRDIAVRNILVASPECVKLGDFGLSRY
IEDEDYYKASVTRLPIKWMSPESINFRRFTTAS
DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLE
KGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFT
ELVCSLSDVYQMEKDIAMEQERNARYRTPKILE
PTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQE
EDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQM
VEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVG
YLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVY
LNVMELVRAVLELKNELCQLPPEGYVVVVKNVGL
TLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNK
DLAELINKMRLAQQNAVTSLSEECKRQMLTASH
TLAVDAKNLLDAVDQAKVLANLAHPPAE*RRVGA
TCLRLPPLPAMYLPCLAVGHVGLPGGRPRGVTF
PCHFARRPLPTPTPGCTAQAAAGQRGLWAMDTG
*R*QRWLRGGLLLPGHCSLSQPGPCRGLLGVGRC
HMVPLALYMDMAGRFGNQAIPFPSSSALRCPLM
HREAGEELCFGGQAASEMRDGPGILVQCILKFI
*CEFGLD*QHVPS*GRTWGTVQEQANWESRHRML
CCQQTKHQGEEAERCGQDRTLGQIRSLPAPLSL
SSFTFPCFSLFSYSSSFSPQPPFSSAPFFSHVF
A*TFF*LLSI*LVVELKLSHL

Sequence NM_004103

GCAGTTCCCGCCTCCTCAGGTCCGGGCGGGTCCCTGGCCGGGGTAGCACGGAAGGGTCTCCCAGGCGGCGTAGTAGGGCTTCCGTGTTACTGGAAACCTA
CTTCCGGCTGCAAATGGGAAAAGGAGCCTCTACCTTAACCAATCCCCGGGAACCTCAGGCCCGCGGATGGGAGAAACCAGAGATGCCAACTTCCTGCTTC
CGAAGTAGTGGCTGGGTCTTAAAGCACCGATGTTTCTGCATTGAATAGCCCTGGAAGACAGAATTCTTGTCTCTCCAAAGATCTGGCAGACTTATTCCCA
ATTATAAGAGATCCTTGCAAAGGAGGTGTCTTGCTTCACCTTCACCTTCCACTGTGATTGTAAGTTTTCTGAGGCCTCGCCAGCCATGCGGAACTGAATA
GGACTAGCAACTTCATAGACGGTTGTGAAGACAAGCTAGACGGCAGATGAAAGTTCTTGGCACAGAGTGAACACTTGATAAACTATATGGCAGCCACAGC
CTCCGGAGCCGTTGCACACCTACCTGCCCGGCCGACTTACCTGTACTTGCCGCCGTCCCGGCTCACCTGGCGGTGCCCGAGGAGTAGTCGCTGGAGTCCG
CGCCTCCCTGGGACTGCAATGTGCCGATCTTAGCTGCTGCCTGAGAGGATGTCTGGGGTGTCCGAGCCCCTGAGTCGAGTAAAGTTGGGCACGTTACGCC
GGCCTGAAGGCCCTGCAGAGCCCATGGTGGTGGTACCAGTAGATGTGGAAAAGGAGGACGTGCGTATCCTCAAGGTCTGCTTCTATAGCAACAGCTTCAA
TCCTGGGAAAAACTTCAAACTGGTCAAATGCACTGTCCAGACGGAGATCCGGGAGATCATCACCTCCATCCTGCTGAGCGGGCGGATCGGGCCCAACATC
CGGTTGGCTGAGTGCTATGGGCTGAGGCTGAAGCACATGAAGTCCGATGAGATCCACTGGCTGCACCCACAGATGACGGTGGGTGAGGTGCAGGACAAGT
ATGAGTGTCTGCACGTGGAAGCCGAGTGGAGGTATGACCTTCAAATCCGCTACTTGCCAGAAGACTTCATGGAGAGCCTGAAGGAGGACAGGACCACGCT
GCTCTATTTTTACCAACAGCTCCGGAACGACTACATGCAGCGCTACGCCAGCAAGGTCAGCGAGGGCATGGCCCTGCAGCTGGGCTGCCTGGAGCTCAGG
CGGTTCTTCAAGGATATGCCCCACAATGCACTTGACAAGAAGTCCAACTTCGAGCTCCTAGAAAAGGAAGTGGGGCTGGACTTGTTTTTCCCAAAGCAGA
TGCAGGAGAACTTAAAGCCCAAACAGTTCCGGAAGATGATCCAGCAGACCTTCCAGCAGTACGCCTCGCTCAGGGAGGAGGAGTGCGTCATGAAGTTCTT
CAACACTCTCGCCGGCTTCGCCAACATCGACCAGGAGACCTACCGCTGTGAACTCATTCAAGGATGGAACATTACTGTGGACCTGGTCATTGGCCCTAAA
GGGATCCGCCAGCTGACTAGTCAGGACGCAAAGCCCACCTGCCTGGCCGAGTTCAAGCAGATCAGGTCCATCAGGTGCCTCCCGCTGGAGGAGGGCCAGG
CAGTACTTCAGCTGGGCATTGAAGGTGCCCCCCAGGCCTTGTCCATCAAAACCTCATCCCTAGCAGAGGCTGAGAACATGGCTGACCTCATAGACGGCTA
CTGCCGGCTGCAGGGTGAGCACCAAGGCTCTCTCATCATCCATCCTAGGAAAGATGGTGAGAAGCGGAACAGCCTGCCCCAGATCCCCATGCTAAACCTG
GAGGCCCGGCGGTCCCACCTCTCAGAGAGCTGCAGCATAGAGTCAGACATCTACGCAGAGATTCCCGACGAAACCCTGCGAAGGCCCGGAGGTCCACAGT
ATGGCATTGCCCGTGAAGATGTGGTCCTGAATCGTATTCTTGGGGAAGGCTTTTTTGGGGAGGTCTATGAAGGTGTCTACACAAATCACAAAGGGGAGAA
AATCAATGTAGCTGTCAAGACCTGCAAGAAAGACTGCACTCTGGACAACAAGGAGAAGTTCATGAGCGAGGCAGTGATCATGAAGAACCTCGACCACCCG
CACATCGTGAAGCTGATCGGCATCATTGAAGAGGAGCCCACCTGGATCATCATGGAATTGTATCCCTATGGGGAGCTGGGCCACTACCTGGAGCGGAACA
AGAACTCCCTGAAGGTGCTCACCCTCGTGCTGTACTCACTGCAGATATGCAAAGCCATGGCCTACCTGGAGAGCATCAACTGCGTGCACAGGGACATTGC
TGTCCGGAACATCCTGGTGGCCTCCCCTGAGTGTGTGAAGCTGGGGGACTTTGGTCTTTCCCGGTACATTGAGGACGAGGACTATTACAAAGCCTCTGTG
ACTCGTCTCCCCATCAAATGGATGTCCCCAGAGTCCATTAACTTCCGACGCTTCACGACAGCCAGTGACGTCTGGATGTTCGCCGTGTGCATGTGGGAGA
TCCTGAGCTTTGGGAAGCAGCCCTTCTTCTGGCTGGAGAACAAGGATGTCATCGGGGTGCTGGAGAAAGGAGACCGGCTGCCCAAGCCTGATCTCTGTCC
ACCGGTCCTTTATACCCTCATGACCCGCTGCTGGGACTACGACCCCAGTGACCGGCCCCGCTTCACCGAGCTGGTGTGCAGCCTCAGTGACGTTTATCAG
ATGGAGAAGGACATTGCCATGGAGCAAGAGAGGAATGCTCGCTACCGAACCCCCAAAATCTTGGAGCCCACAGCCTTCCAGGAACCCCCACCCAAGCCCA
GCCGACCTAAGTACAG
ACCCCCTCCGCAAACCAACCTCCTGGCTCCAAAGCTGCAGTTCCAGGTTCCTGAGGGTCTGTGTGCCAGCTCTCCTACGCTCAC
CAGCCCTATGGAGTATCCATCTCCCGTTAACTCACTGCACACCCCACCTCTCCACCGGCACAATGTCTTCAAACGCCACAGCATGCGG
GAGGAGGACTTC
ATCCAACCCAGCAGCCGAGAAGAGGCCCAGCAGCTGTGGGAGGCTGAAAAGGTCAAAATGCGGCAAATCCTGGACAAACAGCAGAAGCAGATGGTGGAGG
ACTACCAGTGGCTCAGGCAGGAGGAGAAGTCCCTGGACCCCATGGTTTATATGAATGATAAGTCCCCATTGACGCCAGAGAAGGAGGTCGGCTACCTGGA
GTTCACAGGGCCCCCACAGAAGCCCCCGAGGCTGGGCGCACAGTCCATCCAGCCCACAGCTAACCTGGACCGGACTGATGACCTGGTGTACCTCAATGTC
ATGGAGCTGGTGCGGGCCGTGCTGGAGCTCAAGAATGAGCTCTGTCAGCTGCCCCCCGAGGGCTACGTGGTGGTGGTGAAGAATGTGGGGCTGACCCTGC
GGAAGCTCATCGGGAGCGTGGATGATCTCCTGCCTTCCTTGCCGTCATCTTCACGGACAGAGATCGAGGGCACCCAGAAACTGCTCAACAAAGACCTGGC
AGAGCTCATCAACAAGATGCGGCTGGCACAGCAGAACGCCGTGACCTCCCTAAGTGAGGAGTGCAAGAGGCAGATGCTGACGGCTTCACACACCCTGGCT
GTGGACGCCAAGAACCTGCTCGACGCTGTGGACCAGGCCAAGGTTCTGGCCAATCTGGCCCACCCACCTGCAGAGTGACGGAGGGTGGGGGCCACCTGCC
TGCGTCTTCCGCCCCTGCCTGCCATGTACCTCCCCTGCCTTGCTGTTGGTCATGTGGGTCTTCCAGGGGGAAGGCCAAGGGGAGTCACCTTCCCTTGCCA
CTTTGCACGACGCCCTCTCCCCACCCCTACCCCTGGCTGTACTGCTCAGGCTGCAGCTGGACAGAGGGGACTCTGGGCTATGGACACAGGGTGACGGTGA
CAAAGATGGCTCAGAGGGGGACTGCTGCTGCCTGGCCACTGCTCCCTAAGCCAGCCTGGTCCATGCAGGGGGCTCCTGGGGGTGGGGAGGTGTCACATGG
TGCCCCTAGCTTTATATATGGACATGGCAGGCCGATTTGGGAACCAAGCTATTCCTTTCCCTTCCTCTTCGGCCCTCAGATGTCCCTTGATGCACAGAGA
AGCTGGGGAGGAGCTTTGTTTTGGGGGTCAGGCAGCCAGTGAGATGAGGGATGGGCCTGGCATTCTTGTACAGTGTATATTGAAATTTATTTAATGTGAG
TTTGGTCTGGACTGACAGCATGTGCCCTCCTGAGGGAGGACCTGGGGCACAGTCCAGGAACAAGCTAATTGGGAGTCCAGGCACAGGATGCTGTGTTGTC
AACAAACCAAGCATCAGGGGGAAGAAGCAGAGAGATGCGGCCAAGATAGGACCTTGGGCCAAATCCGCTCTCTTCCTGCCCCTCTTTCTCTTTCTTCCTT
TACTTTCCCTTGCTTTTCCCTCTTTTCTTACTCCTCCTCTTTCTCTCCCCAACCCCCATTCTCATCTGCACCCTTCTTTTCTCATGTGTTTGCATAAACA
TTCTTTTAACTTCTTTCTATTTGACTTGTGGTTGAATTAAAATTGTCCCATTTGC
  • refseq_PTK2B.F1 (forward primer)
  • refseq_PTK2B.R1 (reverse primer)
  • Single exon skipping

Frame 0

AVPASSGPGGSLAGVARKGLPGGVVGLPCYWKP
TSGCKWEKEPLP*PIPGNLRPADGRNQRCQLPAS
EVVAGS*STDVSALNSPGRQNSCLSKDLADLFP
IIRDPCKGGVLLHLHLPL*L*VF*GLASHAELN
RTSNFIDGCEDKLDGR*KFLAQSEHLINYMAATA
SGAVAHLPARPTYLYLPPSRLTWRCPRSSRWSP
RLPGTAMCRS*LLPERMSGVSEPLSRVKLGTLR
RPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFN
PGKNFKLVKCTVQTEIREIITSILLSGRIGPNI
RLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDK
YECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTL
LYFYQQLRNDYMQRYASKVSEGMALQLGCLELR
RFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQ
MQENLKPKQFRKMIQQTFQQYASLREEECVMKFF
NTLAGFANIDQETYRCELIQGWNITVDLVIGPK
GIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEGQ
AVLQLGIEGAPQALSIKTSSLAEAENMADLIDGY
CRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNL
EARRSHLSESCSIESDIYAEIPDETLRRPGGPQ
YGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEK
INVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHP
HIVKLIGIIEEEPTWIIMELYPYGELGHYLERN
KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIA
VRNILVASPECVKLGDFGLSRYIEDEDYYKASV
TRLPIKWMSPESINFRRFTTASDVWMFAVCMWE
ILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP
PVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQ
MEKDIAMEQERNARYRTPKILEPTAFQEPPPKP
SRPKYR
PPPQTNLLAPKLQFQVPEGLCASSPTLT
SPMEYPSPVNSLHTPPLHRHNVFKRHSMR
EEDF
IQPSSREEAQQLWEAEKVKMRQILDKQQKQMVE
DYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLE
FTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNV
MELVRAVLELKNELCQLPPEGYVVVVKNVGLTL
RKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLA
ELINKMRLAQQNAVTSLSEECKRQMLTASHTLA
VDAKNLLDAVDQAKVLANLAHPPAE*RRVGATC
LRLPPLPAMYLPCLAVGHVGLPGGRPRGVTFPCH
FARRPLPTPTPGCTAQAAAGQRGLWAMDTG*R*
QRWLRGGLLLPGHCSLSQPGPCRGLLGVGRCHM
VPLALYMDMAGRFGNQAIPFPSSSALRCPLMHRE
AGEELCFGGQAASEMRDGPGILVQCILKFI*CE
FGLD*QHVPS*GRTWGTVQEQANWESRHRMLCC
QQTKHQGEEAERCGQDRTLGQIRSLPAPLSLSSF
TFPCFSLFSYSSSFSPQPPFSSAPFFSHVFA*T
FF*LLSI*LVVELKLSHL

Frame 1

QFPPPQVRAGPWPG*HGRVSQAA**GFRVTGNL
LPAANGKRSLYLNQSPGTSGPRMGETRDANFLL
PK*WLGLKAPMFLH*IALEDRILVSPKIWQTYSQ
L*EILAKEVSCFTFTFHCDCKFSEASPAMRN*I
GLATS*TVVKTS*TADESSWHRVNT**TIWQPQ
PPEPLHTYLPGRLTCTCRRPGSPGGARGVVAGVR
ASLGLQCADLSCCLRGCLGCPSP*VE*SWARYA
GLKALQSPWWWYQ*MWKRRTCVSSRSASIATAS
ILGKTSNWSNALSRRRSGRSSPPSC*AGGSGPTS
GWLSAMG*G*ST*SPMRSTGCTHR*RWVRCRTS
MSVCTWKPSGGMTFKSATCQKTSWRA*RRTGPR
CSIFTNSSGTTTCSATPARSARAWPCSWAAWSSG
GSSRICPTMHLTRSPTSSS*KRKWGWTCFSQSR
CRRT*SPNSSGR*SSRPSSSTPRSGRRSAS*SS
STLSPASPTSTRRPTAVNSFKDGTLLWTWSLALK
GSAS*LVRTQSPPAWPSSSRSGPSGASRWRRAR
QYFSWALKVPPRPCPSKPHP*QRLRTWLTS*TA
TAGCRVSTKALSSSILGKMVRSGTACPRSPC*TW
RPGGPTSQRAAA*SQTSTQRFPTKPCEGPEVHS
MALPVKMWS*IVFLGKAFLGRSMKVSTQITKGR
KSM*LSRPARKTALWTTRRSS*ARQ*S*RTSTTR
TS*S*SASLKRSPPGSSWNCIPMGSWATTWSGT
RTP*RCSPSCCTHCRYAKPWPTWRASTACTGTL
LSGTSWWPPLSV*SWGTLVFPGTLRTRTITKPL*
LVSPSNGCPQSPLTSDASRQPVTSGCSPCACGR
S*ALGSSPSSGWRTRMSSGCWRKETGCPSLISV
HRSFIPS*PAAGTTTPVTGPASPSWCAASVTFIR
WRRTLPWSKRGMLATEPPKSWSPQPSRNPHPSP
ADLST
DPLRKPTSWLQSCSSRFLRVCVPALLRS
PALWSIHLPLTHCTPHLSTGTMSSNATACG
RRTS
SNPAAEKRPSSCGRLKRSKCGKSWTNSRSRWWR
TTSGSGRRRSPWTPWFI*MISPH*RQRRRSATW
SSQGPHRSPRGWAHSPSSPQLTWTGLMTWCTSMS
WSWCGPCWSSRMSSVSCPPRATWWW*RMWG*PC
GSSSGAWMISCLPCRHLHGQRSRAPRNCSTKTW
QSSSTRCGWHSRTP*PP*VRSARGRC*RLHTPWL
WTPRTCSTLWTRPRFWPIWPTHLQSDGGWGPPA
CVFRPCLPCTSPALLLVMWVFQGEGQGESPSLA
TLHDALSPPLPLAVLLRLQLDRGDSGLWTQGDGD
KDGSEGDCCCLATAP*ASLVHAGGSWGWGGVTW
CP*LYIWTWQADLGTKLFLSLPLRPSDVP*CTE
KLGRSFVLGVRQPVR*GMGLAFLYSVY*NLFNVS
LVWTDSMCPPEGGPGAQSRNKLIGSPGTGCCVV
NKPSIRGKKQRDAAKIGPWAKSALFLPLFLFLP
LLSLAFPSFLTPPLSLPNPHSHLHPSFLMCLHKH
SFNFFLFDLWLN*NCPIC

Frame 2

SSRLLRSGRVPGRGSTEGSPRRRSRASVLLETY
FRLQMGKGASTLTNPREPQARGWEKPEMPTSCF
RSSGWVLKHRCFCIE*PWKTEFLSLQRSGRLIP
NYKRSLQRRCLASPSPSTVIVSFLRPRQPCGTE*
D*QLHRRL*RQARRQMKVLGTE*TLDKLYGSHS
LRSRCTPTCPADLPVLAAVPAHLAVPEE*SLES
APPWDCNVPILAAA*EDVWGVRAPESSKVGHVTP
A*RPCRAHGGGTSRCGKGGRAYPQGLLL*QQLQ
SWEKLQTGQMHCPDGDPGDHHLHPAERADRAQH
PVG*VLWAEAEAHEVR*DPLAAPTDDGG*GAGQV
*VSARGSRVEV*PSNPLLARRLHGEPEGGQDHA
ALFLPTAPERLHAALRQQGQRGHGPAAGLPGAQ
AVLQGYAPQCT*QEVQLRAPRKGSGAGLVFPKAD
AGELKAQTVPEDDPADLPAVRLAQGGGVRHEVL
QHSRRLRQHRPGDLPL*THSRMEHYCGPGHWP*
RDPPAD*SGRKAHLPGRVQADQVHQVPPAGGGPG
STSAGH*RCPPGLVHQNLIPSRG*EHG*PHRRL
LPAAG*APRLSHHPS*ERW*EAEQPAPDPHAKP
GGPAVPPLRELQHRVRHLRRDSRRNPAKARRSTV
WHCP*RCGPESYSWGRLFWGGL*RCLHKSQRGE
NQCSCQDLQERLHSGQQGEVHERGSDHEEPRPP
AHREADRHH*RGAHLDHHGIVSLWGAGPLPGAEQ
ELPEGAHPRAVLTADMQSHGLPGEHQLRAQGHC
CPEHPGGLP*VCEAGGLWSFPVH*GRGLLQSLC
DSSPHQMDVPRVH*LPTLHDSQ*RLDVRRVHVGD
PELWEAALLLAGEQGCHRGAGERRPAAQA*SLS
TGPLYPHDPLLGLRPQ*PAPLHRAGVQPQ*RLS
DGEGHCHGAREECSLPNPQNLGAHSLPGTPTQAQ
PT*VQ
TPSANQPPGSKAAVPGS*GSVCQLSYAH
QPYGVSISR*LTAHPTSPPAQCLQTPQHA
GGGL
HPTQQPRRGPAAVGG*KGQNAANPGQTAEADGGG
LPVAQAGGEVPGPHGLYE**VPIDAREGGRLPG
VHRAPTEAPEAGRTVHPAHS*PGPD**PGVPQC
HGAGAGRAGAQE*ALSAAPRGLRGGGEECGADPA
EAHRERG*SPAFLAVIFTDRDRGHPETAQQRPG
RAHQQDAAGTAERRDLPK*GVQEADADGFTHPG
CGRQEPARRCGPGQGSGQSGPPTCRVTEGGGHLP
ASSAPACHVPPLPCCWSCGSSRGKAKGSHLPLP
LCTTPSPHPYPWLYCSGCSWTEGTLGYGHRVTV
TKMAQRGTAAAWPLLPKPAWSMQGAPGGGEVSHG
APSFIYGHGRPIWEPSYSFPFLFGPQMSLDAQR
SWGGALFWGSGSQ*DEGWAWHSCTVYIEIYLM*
VWSGLTACALLREDLGHSPGTS*LGVQAQDAVLS
TNQASGGRSREMRPR*DLGPNPLSSCPSFSFFL
YFPLLFPLFLLLLFLSPTPILICTLLFSCVCIN
ILLTSFYLTCG*IKIVPF

Sequence NM_173174

GCAGTTCCCGCCTCCTCAGGTCCGGGCGGGTCCCTGGCCGGGGTAGCACGGAAGGGTCTCCCAGGCGGCGTAGTAGGGCTTCCGTGTTACTGGAAACCTA
CTTCCGGCTGCAAATGGGAAAAGGAGCCTCTACCTTAACCAATCCCCGGGAACCTCAGGCCCGCGGATGGGAGAAACCAGAGATGCCAACTTCCTGCTTC
CGAAGTAGTGGCTGGGTCTTAAAGCACCGATGTTTCTGCATTGAATAGCCCTGGAAGACAGAATTCTTGTCTCTCCAAAGATCTGGCAGACTTATTCCCA
ATTATAAGAGATCCTTGCAAAGGAGGTGTCTTGCTTCACCTTCACCTTCCACTGTGATTGTAAGTTTTCTGAGGCCTCGCCAGCCATGCGGAACTGAATA
GGACTAGCAACTTCATAGACGGTTGTGAAGACAAGCTAGACGGCAGATGAAAGTTCTTGGCACAGAGTGAACACTTGATAAACTATATGGCAGGGAGGGC
TGGAACGGGGCTTGTTTGAAGAGCAATATGAGCCAGGGTTATAGACCTGAGTTTGGGGTAAGAGTGGAACATCCAAATGGAAGAGTCCAGCAGCTGAAAG
GACATTTGTTCAAAGGCCTTTTTCATTACAGTTTTCTCCTTCTTCTGATCCAGCCACAGCCTCCGGAGCCGTTGCACACCTACCTGCCCGGCCGACTTAC
CTGTACTTGCCGCCGTCCCGGCTCACCTGGCGGTGCCCGAGGAGTAGTCGCTGGAGTCCGCGCCTCCCTGGGACTGCAATGTGCCGATCTTAGCTGCTGC
CTGAGAGGATGTCTGGGGTGTCCGAGCCCCTGAGTCGAGTAAAGTTGGGCACGTTACGCCGGCCTGAAGGCCCTGCAGAGCCCATGGTGGTGGTACCAGT
AGATGTGGAAAAGGAGGACGTGCGTATCCTCAAGGTCTGCTTCTATAGCAACAGCTTCAATCCTGGGAAAAACTTCAAACTGGTCAAATGCACTGTCCAG
ACGGAGATCCGGGAGATCATCACCTCCATCCTGCTGAGCGGGCGGATCGGGCCCAACATCCGGTTGGCTGAGTGCTATGGGCTGAGGCTGAAGCACATGA
AGTCCGATGAGATCCACTGGCTGCACCCACAGATGACGGTGGGTGAGGTGCAGGACAAGTATGAGTGTCTGCACGTGGAAGCCGAGTGGAGGTATGACCT
TCAAATCCGCTACTTGCCAGAAGACTTCATGGAGAGCCTGAAGGAGGACAGGACCACGCTGCTCTATTTTTACCAACAGCTCCGGAACGACTACATGCAG
CGCTACGCCAGCAAGGTCAGCGAGGGCATGGCCCTGCAGCTGGGCTGCCTGGAGCTCAGGCGGTTCTTCAAGGATATGCCCCACAATGCACTTGACAAGA
AGTCCAACTTCGAGCTCCTAGAAAAGGAAGTGGGGCTGGACTTGTTTTTCCCAAAGCAGATGCAGGAGAACTTAAAGCCCAAACAGTTCCGGAAGATGAT
CCAGCAGACCTTCCAGCAGTACGCCTCGCTCAGGGAGGAGGAGTGCGTCATGAAGTTCTTCAACACTCTCGCCGGCTTCGCCAACATCGACCAGGAGACC
TACCGCTGTGAACTCATTCAAGGATGGAACATTACTGTGGACCTGGTCATTGGCCCTAAAGGGATCCGCCAGCTGACTAGTCAGGACGCAAAGCCCACCT
GCCTGGCCGAGTTCAAGCAGATCAGGTCCATCAGGTGCCTCCCGCTGGAGGAGGGCCAGGCAGTACTTCAGCTGGGCATTGAAGGTGCCCCCCAGGCCTT
GTCCATCAAAACCTCATCCCTAGCAGAGGCTGAGAACATGGCTGACCTCATAGACGGCTACTGCCGGCTGCAGGGTGAGCACCAAGGCTCTCTCATCATC
CATCCTAGGAAAGATGGTGAGAAGCGGAACAGCCTGCCCCAGATCCCCATGCTAAACCTGGAGGCCCGGCGGTCCCACCTCTCAGAGAGCTGCAGCATAG
AGTCAGACATCTACGCAGAGATTCCCGACGAAACCCTGCGAAGGCCCGGAGGTCCACAGTATGGCATTGCCCGTGAAGATGTGGTCCTGAATCGTATTCT
TGGGGAAGGCTTTTTTGGGGAGGTCTATGAAGGTGTCTACACAAATCACAAAGGGGAGAAAATCAATGTAGCTGTCAAGACCTGCAAGAAAGACTGCACT
CTGGACAACAAGGAGAAGTTCATGAGCGAGGCAGTGATCATGAAGAACCTCGACCACCCGCACATCGTGAAGCTGATCGGCATCATTGAAGAGGAGCCCA
CCTGGATCATCATGGAATTGTATCCCTATGGGGAGCTGGGCCACTACCTGGAGCGGAACAAGAACTCCCTGAAGGTGCTCACCCTCGTGCTGTACTCACT
GCAGATATGCAAAGCCATGGCCTACCTGGAGAGCATCAACTGCGTGCACAGGGACATTGCTGTCCGGAACATCCTGGTGGCCTCCCCTGAGTGTGTGAAG
CTGGGGGACTTTGGTCTTTCCCGGTACATTGAGGACGAGGACTATTACAAAGCCTCTGTGACTCGTCTCCCCATCAAATGGATGTCCCCAGAGTCCATTA
ACTTCCGACGCTTCACGACAGCCAGTGACGTCTGGATGTTCGCCGTGTGCATGTGGGAGATCCTGAGCTTTGGGAAGCAGCCCTTCTTCTGGCTGGAGAA
CAAGGATGTCATCGGGGTGCTGGAGAAAGGAGACCGGCTGCCCAAGCCTGATCTCTGTCCACCGGTCCTTTATACCCTCATGACCCGCTGCTGGGACTAC
GACCCCAGTGACCGGCCCCGCTTCACCGAGCTGGTGTGCAGCCTCAGTGACGTTTATCAGATGGAGAAGGACATTGCCATGGAGCAAGAGAGGAATGCTC
GCTACCGAACCCCCAAAATCTTGGAGCCCACAGCCTTCCAGGAACCCCCACCCAAGCCCAGCCGACCTAAGTACAGACCCCCTCCGCAAACCAACCTCCT
GGCTCCAAAGCTGCAGTTCCAGGTTCCTGAGGGTCTGTGTGCCAGCTCTCCTACGCTCACCAGCCCTATGGAGTATCCATCTCCCGTTAACTCACTGCAC
ACCCCACCTCTCCACCGGCACAATGTCTTCAAACGCCACAGCATGCGG
GAGGAGGACTTCATCCAACCCAGCAGCCGAGAAGAGGCCCAGCAGCTGTGGG
AGGCTGAAAAGGTCAAAATGCGGCAAATCCTGGACAAACAGCAGAAGCAGATGGTGGAGGACTACCAGTGGCTCAGGCAGGAGGAGAAGTCCCTGGACCC
CATGGTTTATATGAATGATAAGTCCCCATTGACGCCAGAGAAGGAGGTCGGCTACCTGGAGTTCACAGGGCCCCCACAGAAGCCCCCGAGGCTGGGCGCA
CAGTCCATCCAGCCCACAGCTAACCTGGACCGGACTGATGACCTGGTGTACCTCAATGTCATGGAGCTGGTGCGGGCCGTGCTGGAGCTCAAGAATGAGC
TCTGTCAGCTGCCCCCCGAGGGCTACGTGGTGGTGGTGAAGAATGTGGGGCTGACCCTGCGGAAGCTCATCGGGAGCGTGGATGATCTCCTGCCTTCCTT
GCCGTCATCTTCACGGACAGAGATCGAGGGCACCCAGAAACTGCTCAACAAAGACCTGGCAGAGCTCATCAACAAGATGCGGCTGGCACAGCAGAACGCC
GTGACCTCCCTAAGTGAGGAGTGCAAGAGGCAGATGCTGACGGCTTCACACACCCTGGCTGTGGACGCCAAGAACCTGCTCGACGCTGTGGACCAGGCCA
AGGTTCTGGCCAATCTGGCCCACCCACCTGCAGAGTGACGGAGGGTGGGGGCCACCTGCCTGCGTCTTCCGCCCCTGCCTGCCATGTACCTCCCCTGCCT
TGCTGTTGGTCATGTGGGTCTTCCAGGGGGAAGGCCAAGGGGAGTCACCTTCCCTTGCCACTTTGCACGACGCCCTCTCCCCACCCCTACCCCTGGCTGT
ACTGCTCAGGCTGCAGCTGGACAGAGGGGACTCTGGGCTATGGACACAGGGTGACGGTGACAAAGATGGCTCAGAGGGGGACTGCTGCTGCCTGGCCACT
GCTCCCTAAGCCAGCCTGGTCCATGCAGGGGGCTCCTGGGGGTGGGGAGGTGTCACATGGTGCCCCTAGCTTTATATATGGACATGGCAGGCCGATTTGG
GAACCAAGCTATTCCTTTCCCTTCCTCTTCGGCCCTCAGATGTCCCTTGATGCACAGAGAAGCTGGGGAGGAGCTTTGTTTTGGGGGTCAGGCAGCCAGT
GAGATGAGGGATGGGCCTGGCATTCTTGTACAGTGTATATTGAAATTTATTTAATGTGAGTTTGGTCTGGACTGACAGCATGTGCCCTCCTGAGGGAGGA
CCTGGGGCACAGTCCAGGAACAAGCTAATTGGGAGTCCAGGCACAGGATGCTGTGTTGTCAACAAACCAAGCATCAGGGGGAAGAAGCAGAGAGATGCGG
CCAAGATAGGACCTTGGGCCAAATCCGCTCTCTTCCTGCCCCTCTTTCTCTTTCTTCCTTTACTTTCCCTTGCTTTTCCCTCTTTTCTTACTCCTCCTCT
TTCTCTCCCCAACCCCCATTCTCATCTGCACCCTTCTTTTCTCATGTGTTTGCATAAACATTCTTTTAACTTCTTTCTATTTGACTTGTGGTTGAATTAA
AATTGTCCCATTTGC
  • refseq_PTK2B.F1 (forward primer)
  • refseq_PTK2B.R1 (reverse primer)
  • Single exon skipping

Frame 0

AVPASSGPGGSLAGVARKGLPGGVVGLPCYWKP
TSGCKWEKEPLP*PIPGNLRPADGRNQRCQLPAS
EVVAGS*STDVSALNSPGRQNSCLSKDLADLFP
IIRDPCKGGVLLHLHLPL*L*VF*GLASHAELN
RTSNFIDGCEDKLDGR*KFLAQSEHLINYMAGRA
GTGLV*RAI*ARVIDLSLG*EWNIQMEESSS*K
DICSKAFFITVFSFF*SSHSLRSRCTPTCPADL
PVLAAVPAHLAVPEE*SLESAPPWDCNVPILAAA
*EDVWGVRAPESSKVGHVTPA*RPCRAHGGGTS
RCGKGGRAYPQGLLL*QQLQSWEKLQTGQMHCP
DGDPGDHHLHPAERADRAQHPVG*VLWAEAEAHE
VR*DPLAAPTDDGG*GAGQV*VSARGSRVEV*P
SNPLLARRLHGEPEGGQDHAALFLPTAPERLHA
ALRQQGQRGHGPAAGLPGAQAVLQGYAPQCT*QE
VQLRAPRKGSGAGLVFPKADAGELKAQTVPEDD
PADLPAVRLAQGGGVRHEVLQHSRRLRQHRPGD
LPL*THSRMEHYCGPGHWP*RDPPAD*SGRKAHL
PGRVQADQVHQVPPAGGGPGSTSAGH*RCPPGL
VHQNLIPSRG*EHG*PHRRLLPAAG*APRLSHH
PS*ERW*EAEQPAPDPHAKPGGPAVPPLRELQHR
VRHLRRDSRRNPAKARRSTVWHCP*RCGPESYS
WGRLFWGGL*RCLHKSQRGENQCSCQDLQERLH
SGQQGEVHERGSDHEEPRPPAHREADRHH*RGAH
LDHHGIVSLWGAGPLPGAEQELPEGAHPRAVLT
ADMQSHGLPGEHQLRAQGHCCPEHPGGLP*VCE
AGGLWSFPVH*GRGLLQSLCDSSPHQMDVPRVH*
LPTLHDSQ*RLDVRRVHVGDPELWEAALLLAGE
QGCHRGAGERRPAAQA*SLSTGPLYPHDPLLGL
RPQ*PAPLHRAGVQPQ*RLSDGEGHCHGAREECS
LPNPQNLGAHSLPGTPTQAQPT*VQTPSANQPP
GSKAAVPGS*GSVCQLSYAHQPYGVSISR*LTA
HPTSPPAQCLQTPQHA
GGGLHPTQQPRRGPAAVG
G*KGQNAANPGQTAEADGGGLPVAQAGGEVPGP
HGLYE**VPIDAREGGRLPGVHRAPTEAPEAGR
TVHPAHS*PGPD**PGVPQCHGAGAGRAGAQE*A
LSAAPRGLRGGGEECGADPAEAHRERG*SPAFL
AVIFTDRDRGHPETAQQRPGRAHQQDAAGTAER
RDLPK*GVQEADADGFTHPGCGRQEPARRCGPGQ
GSGQSGPPTCRVTEGGGHLPASSAPACHVPPLP
CCWSCGSSRGKAKGSHLPLPLCTTPSPHPYPWL
YCSGCSWTEGTLGYGHRVTVTKMAQRGTAAAWPL
LPKPAWSMQGAPGGGEVSHGAPSFIYGHGRPIW
EPSYSFPFLFGPQMSLDAQRSWGGALFWGSGSQ
*DEGWAWHSCTVYIEIYLM*VWSGLTACALLRED
LGHSPGTS*LGVQAQDAVLSTNQASGGRSREMR
PR*DLGPNPLSSCPSFSFFLYFPLLFPLFLLLL
FLSPTPILICTLLFSCVCINILLTSFYLTCG*IK
IVPF

Frame 1

QFPPPQVRAGPWPG*HGRVSQAA**GFRVTGNL
LPAANGKRSLYLNQSPGTSGPRMGETRDANFLL
PK*WLGLKAPMFLH*IALEDRILVSPKIWQTYSQ
L*EILAKEVSCFTFTFHCDCKFSEASPAMRN*I
GLATS*TVVKTS*TADESSWHRVNT**TIWQGG
LERGLFEEQYEPGL*T*VWGKSGTSKWKSPAAER
TFVQRPFSLQFSPSSDPATASGAVAHLPARPTY
LYLPPSRLTWRCPRSSRWSPRLPGTAMCRS*LL
PERMSGVSEPLSRVKLGTLRRPEGPAEPMVVVPV
DVEKEDVRILKVCFYSNSFNPGKNFKLVKCTVQ
TEIREIITSILLSGRIGPNIRLAECYGLRLKHM
KSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDL
QIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQ
RYASKVSEGMALQLGCLELRRFFKDMPHNALDK
KSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMI
QQTFQQYASLREEECVMKFFNTLAGFANIDQET
YRCELIQGWNITVDLVIGPKGIRQLTSQDAKPT
CLAEFKQIRSIRCLPLEEGQAVLQLGIEGAPQAL
SIKTSSLAEAENMADLIDGYCRLQGEHQGSLII
HPRKDGEKRNSLPQIPMLNLEARRSHLSESCSI
ESDIYAEIPDETLRRPGGPQYGIAREDVVLNRIL
GEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCT
LDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEP
TWIIMELYPYGELGHYLERNKNSLKVLTLVLYSL
QICKAMAYLESINCVHRDIAVRNILVASPECVK
LGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI
NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLEN
KDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDY
DPSDRPRFTELVCSLSDVYQMEKDIAMEQERNA
RYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLL
APKLQFQVPEGLCASSPTLTSPMEYPSPVNSLH
TPPLHRHNVFKRHSMR
EEDFIQPSSREEAQQLW
EAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDP
MVYMNDKSPLTPEKEVGYLEFTGPPQKPPRLGA
QSIQPTANLDRTDDLVYLNVMELVRAVLELKNE
LCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSL
PSSSRTEIEGTQKLLNKDLAELINKMRLAQQNA
VTSLSEECKRQMLTASHTLAVDAKNLLDAVDQA
KVLANLAHPPAE*RRVGATCLRLPPLPAMYLPCL
AVGHVGLPGGRPRGVTFPCHFARRPLPTPTPGC
TAQAAAGQRGLWAMDTG*R*QRWLRGGLLLPGH
CSLSQPGPCRGLLGVGRCHMVPLALYMDMAGRFG
NQAIPFPSSSALRCPLMHREAGEELCFGGQAAS
EMRDGPGILVQCILKFI*CEFGLD*QHVPS*GR
TWGTVQEQANWESRHRMLCCQQTKHQGEEAERCG
QDRTLGQIRSLPAPLSLSSFTFPCFSLFSYSSS
FSPQPPFSSAPFFSHVFA*TFF*LLSI*LVVEL
KLSHL

Frame 2

SSRLLRSGRVPGRGSTEGSPRRRSRASVLLETY
FRLQMGKGASTLTNPREPQARGWEKPEMPTSCF
RSSGWVLKHRCFCIE*PWKTEFLSLQRSGRLIP
NYKRSLQRRCLASPSPSTVIVSFLRPRQPCGTE*
D*QLHRRL*RQARRQMKVLGTE*TLDKLYGREG
WNGACLKSNMSQGYRPEFGVRVEHPNGRVQQLK
GHLFKGLFHYSFLLLLIQPQPPEPLHTYLPGRLT
CTCRRPGSPGGARGVVAGVRASLGLQCADLSCC
LRGCLGCPSP*VE*SWARYAGLKALQSPWWWYQ
*MWKRRTCVSSRSASIATASILGKTSNWSNALSR
RRSGRSSPPSC*AGGSGPTSGWLSAMG*G*ST*
SPMRSTGCTHR*RWVRCRTSMSVCTWKPSGGMT
FKSATCQKTSWRA*RRTGPRCSIFTNSSGTTTCS
ATPARSARAWPCSWAAWSSGGSSRICPTMHLTR
SPTSSS*KRKWGWTCFSQSRCRRT*SPNSSGR*
SSRPSSSTPRSGRRSAS*SSSTLSPASPTSTRRP
TAVNSFKDGTLLWTWSLALKGSAS*LVRTQSPP
AWPSSSRSGPSGASRWRRARQYFSWALKVPPRP
CPSKPHP*QRLRTWLTS*TATAGCRVSTKALSSS
ILGKMVRSGTACPRSPC*TWRPGGPTSQRAAA*
SQTSTQRFPTKPCEGPEVHSMALPVKMWS*IVF
LGKAFLGRSMKVSTQITKGRKSM*LSRPARKTAL
WTTRRSS*ARQ*S*RTSTTRTS*S*SASLKRSP
PGSSWNCIPMGSWATTWSGTRTP*RCSPSCCTH
CRYAKPWPTWRASTACTGTLLSGTSWWPPLSV*S
WGTLVFPGTLRTRTITKPL*LVSPSNGCPQSPL
TSDASRQPVTSGCSPCACGRS*ALGSSPSSGWR
TRMSSGCWRKETGCPSLISVHRSFIPS*PAAGTT
TPVTGPASPSWCAASVTFIRWRRTLPWSKRGML
ATEPPKSWSPQPSRNPHPSPADLSTDPLRKPTS
WLQSCSSRFLRVCVPALLRSPALWSIHLPLTHCT
PHLSTGTMSSNATACG
RRTSSNPAAEKRPSSCG
RLKRSKCGKSWTNSRSRWWRTTSGSGRRRSPWT
PWFI*MISPH*RQRRRSATWSSQGPHRSPRGWAH
SPSSPQLTWTGLMTWCTSMSWSWCGPCWSSRMS
SVSCPPRATWWW*RMWG*PCGSSSGAWMISCLP
CRHLHGQRSRAPRNCSTKTWQSSSTRCGWHSRTP
*PP*VRSARGRC*RLHTPWLWTPRTCSTLWTRP
RFWPIWPTHLQSDGGWGPPACVFRPCLPCTSPA
LLLVMWVFQGEGQGESPSLATLHDALSPPLPLAV
LLRLQLDRGDSGLWTQGDGDKDGSEGDCCCLAT
AP*ASLVHAGGSWGWGGVTWCP*LYIWTWQADL
GTKLFLSLPLRPSDVP*CTEKLGRSFVLGVRQPV
R*GMGLAFLYSVY*NLFNVSLVWTDSMCPPEGG
PGAQSRNKLIGSPGTGCCVVNKPSIRGKKQRDA
AKIGPWAKSALFLPLFLFLPLLSLAFPSFLTPPL
SLPNPHSHLHPSFLMCLHKHSFNFFLFDLWLN*
NCPIC

Sequence NM_173176

ATCTAACCTGTCAGCCCTTTTACTCAGCCACAGCCTCCGGAGCCGTTGCACACCTACCTGCCCGGCCGACTTACCTGTACTTGCCGCCGTCCCGGCTCAC
CTGGCGGTGCCCGAGGAGTAGTCGCTGGAGTCCGCGCCTCCCTGGGACTGCAATGTGCCGATCTTAGCTGCTGCCTGAGAGGATGTCTGGGGTGTCCGAG
CCCCTGAGTCGAGTAAAGTTGGGCACGTTACGCCGGCCTGAAGGCCCTGCAGAGCCCATGGTGGTGGTACCAGTAGATGTGGAAAAGGAGGACGTGCGTA
TCCTCAAGGTCTGCTTCTATAGCAACAGCTTCAATCCTGGGAAAAACTTCAAACTGGTCAAATGCACTGTCCAGACGGAGATCCGGGAGATCATCACCTC
CATCCTGCTGAGCGGGCGGATCGGGCCCAACATCCGGTTGGCTGAGTGCTATGGGCTGAGGCTGAAGCACATGAAGTCCGATGAGATCCACTGGCTGCAC
CCACAGATGACGGTGGGTGAGGTGCAGGACAAGTATGAGTGTCTGCACGTGGAAGCCGAGTGGAGGTATGACCTTCAAATCCGCTACTTGCCAGAAGACT
TCATGGAGAGCCTGAAGGAGGACAGGACCACGCTGCTCTATTTTTACCAACAGCTCCGGAACGACTACATGCAGCGCTACGCCAGCAAGGTCAGCGAGGG
CATGGCCCTGCAGCTGGGCTGCCTGGAGCTCAGGCGGTTCTTCAAGGATATGCCCCACAATGCACTTGACAAGAAGTCCAACTTCGAGCTCCTAGAAAAG
GAAGTGGGGCTGGACTTGTTTTTCCCAAAGCAGATGCAGGAGAACTTAAAGCCCAAACAGTTCCGGAAGATGATCCAGCAGACCTTCCAGCAGTACGCCT
CGCTCAGGGAGGAGGAGTGCGTCATGAAGTTCTTCAACACTCTCGCCGGCTTCGCCAACATCGACCAGGAGACCTACCGCTGTGAACTCATTCAAGGATG
GAACATTACTGTGGACCTGGTCATTGGCCCTAAAGGGATCCGCCAGCTGACTAGTCAGGACGCAAAGCCCACCTGCCTGGCCGAGTTCAAGCAGATCAGG
TCCATCAGGTGCCTCCCGCTGGAGGAGGGCCAGGCAGTACTTCAGCTGGGCATTGAAGGTGCCCCCCAGGCCTTGTCCATCAAAACCTCATCCCTAGCAG
AGGCTGAGAACATGGCTGACCTCATAGACGGCTACTGCCGGCTGCAGGGTGAGCACCAAGGCTCTCTCATCATCCATCCTAGGAAAGATGGTGAGAAGCG
GAACAGCCTGCCCCAGATCCCCATGCTAAACCTGGAGGCCCGGCGGTCCCACCTCTCAGAGAGCTGCAGCATAGAGTCAGACATCTACGCAGAGATTCCC
GACGAAACCCTGCGAAGGCCCGGAGGTCCACAGTATGGCATTGCCCGTGAAGATGTGGTCCTGAATCGTATTCTTGGGGAAGGCTTTTTTGGGGAGGTCT
ATGAAGGTGTCTACACAAATCACAAAGGGGAGAAAATCAATGTAGCTGTCAAGACCTGCAAGAAAGACTGCACTCTGGACAACAAGGAGAAGTTCATGAG
CGAGGCAGTGATCATGAAGAACCTCGACCACCCGCACATCGTGAAGCTGATCGGCATCATTGAAGAGGAGCCCACCTGGATCATCATGGAATTGTATCCC
TATGGGGAGCTGGGCCACTACCTGGAGCGGAACAAGAACTCCCTGAAGGTGCTCACCCTCGTGCTGTACTCACTGCAGATATGCAAAGCCATGGCCTACC
TGGAGAGCATCAACTGCGTGCACAGGGACATTGCTGTCCGGAACATCCTGGTGGCCTCCCCTGAGTGTGTGAAGCTGGGGGACTTTGGTCTTTCCCGGTA
CATTGAGGACGAGGACTATTACAAAGCCTCTGTGACTCGTCTCCCCATCAAATGGATGTCCCCAGAGTCCATTAACTTCCGACGCTTCACGACAGCCAGT
GACGTCTGGATGTTCGCCGTGTGCATGTGGGAGATCCTGAGCTTTGGGAAGCAGCCCTTCTTCTGGCTGGAGAACAAGGATGTCATCGGGGTGCTGGAGA
AAGGAGACCGGCTGCCCAAGCCTGATCTCTGTCCACCGGTCCTTTATACCCTCATGACCCGCTGCTGGGACTACGACCCCAGTGACCGGCCCCGCTTCAC
CGAGCTGGTGTGCAGCCTCAGTGACGTTTATCAGATGGAGAAGGACATTGCCATGGAGCAAGAGAGGAATGCTCGCTACCGAACCCCCAAAATCTTGGAG
CCCACAGCCTTCCAGGAACCCCCACCCAAGCCCAGCCGACCTAAGTACAGACCCCCTCCGCAAACCAACCTCCTGGCTCCAAAGCTGCAGTTCCAGGTTC
CTGAGGGTCTGTGTGCCAGCTCTCCTACGCTCACCAGCCCTATGGAGTATCCATCTCCCGTTAACTCACTGCACACCCCACCTCTCCACCGGCACAATGT
CTTCAAACGCCACAGCATGCGG
GAGGAGGACTTCATCCAACCCAGCAGCCGAGAAGAGGCCCAGCAGCTGTGGGAGGCTGAAAAGGTCAAAATGCGGCAA
ATCCTGGACAAACAG
CAGAAGCAGATGGTGGAGGACTACCAGTGGCTCAGGCAGGAGGAGAAGTCCCTGGACCCCATGGTTTATATGAATGATAAGTCCC
CATTGACGCCAGAGAAGGAGGTCGGCTACCTGGAGTTCACAGGGCCCCCACAGAAGCCCCCGAGGCTGGGCGCACAGTCCATCCAGCCCACAGCTAACCT
GGACCGGACTGATGACCTGGTGTACCTCAATGTCATGGAGCTGGTGCGGGCCGTGCTGGAGCTCAAGAATGAGCTCTGTCAGCTGCCCCCCGAGGGCTAC
GTGGTGGTGGTGAAGAATGTGGGGCTGACCCTGCGGAAGCTCATCGGGAGCGTGGATGATCTCCTGCCTTCCTTGCCGTCATCTTCACGGACAGAGATCG
AGGGCACCCAGAAACTGCTCAACAAAGACCTGGCAGAGCTCATCAACAAGATGCGGCTGGCACAGCAGAACGCCGTGACCTCCCTAAGTGAGGAGTGCAA
GAGGCAGATGCTGACGGCTTCACACACCCTGGCTGTGGACGCCAAGAACCTGCTCGACGCTGTGGACCAGGCCAAGGTTCTGGCCAATCTGGCCCACCCA
CCTGCAGAGTGACGGAGGGTGGGGGCCACCTGCCTGCGTCTTCCGCCCCTGCCTGCCATGTACCTCCCCTGCCTTGCTGTTGGTCATGTGGGTCTTCCAG
GGGGAAGGCCAAGGGGAGTCACCTTCCCTTGCCACTTTGCACGACGCCCTCTCCCCACCCCTACCCCTGGCTGTACTGCTCAGGCTGCAGCTGGACAGAG
GGGACTCTGGGCTATGGACACAGGGTGACGGTGACAAAGATGGCTCAGAGGGGGACTGCTGCTGCCTGGCCACTGCTCCCTAAGCCAGCCTGGTCCATGC
AGGGGGCTCCTGGGGGTGGGGAGGTGTCACATGGTGCCCCTAGCTTTATATATGGACATGGCAGGCCGATTTGGGAACCAAGCTATTCCTTTCCCTTCCT
CTTCGGCCCTCAGATGTCCCTTGATGCACAGAGAAGCTGGGGAGGAGCTTTGTTTTGGGGGTCAGGCAGCCAGTGAGATGAGGGATGGGCCTGGCATTCT
TGTACAGTGTATATTGAAATTTATTTAATGTGAGTTTGGTCTGGACTGACAGCATGTGCCCTCCTGAGGGAGGACCTGGGGCACAGTCCAGGAACAAGCT
AATTGGGAGTCCAGGCACAGGATGCTGTGTTGTCAACAAACCAAGCATCAGGGGGAAGAAGCAGAGAGATGCGGCCAAGATAGGACCTTGGGCCAAATCC
GCTCTCTTCCTGCCCCTCTTTCTCTTTCTTCCTTTACTTTCCCTTGCTTTTCCCTCTTTTCTTACTCCTCCTCTTTCTCTCCCCAACCCCCATTCTCATC
TGCACCCTTCTTTTCTCATGTGTTTGCATAAACATTCTTTTAACTTCTTTCTATTTGACTTGTGGTTGAATTAAAATTGTCCCATTTGC
  • refseq_PTK2B.F1 (forward primer)
  • refseq_PTK2B.R1 (reverse primer)
  • Single exon skipping

Frame 0

I*PVSPFTQPQPPEPLHTYLPGRLTCTCRRPGS
PGGARGVVAGVRASLGLQCADLSCCLRGCLGCPS
P*VE*SWARYAGLKALQSPWWWYQ*MWKRRTCV
SSRSASIATASILGKTSNWSNALSRRRSGRSSP
PSC*AGGSGPTSGWLSAMG*G*ST*SPMRSTGCT
HR*RWVRCRTSMSVCTWKPSGGMTFKSATCQKT
SWRA*RRTGPRCSIFTNSSGTTTCSATPARSAR
AWPCSWAAWSSGGSSRICPTMHLTRSPTSSS*KR
KWGWTCFSQSRCRRT*SPNSSGR*SSRPSSSTP
RSGRRSAS*SSSTLSPASPTSTRRPTAVNSFKD
GTLLWTWSLALKGSAS*LVRTQSPPAWPSSSRSG
PSGASRWRRARQYFSWALKVPPRPCPSKPHP*Q
RLRTWLTS*TATAGCRVSTKALSSSILGKMVRS
GTACPRSPC*TWRPGGPTSQRAAA*SQTSTQRFP
TKPCEGPEVHSMALPVKMWS*IVFLGKAFLGRS
MKVSTQITKGRKSM*LSRPARKTALWTTRRSS*
ARQ*S*RTSTTRTS*S*SASLKRSPPGSSWNCIP
MGSWATTWSGTRTP*RCSPSCCTHCRYAKPWPT
WRASTACTGTLLSGTSWWPPLSV*SWGTLVFPG
TLRTRTITKPL*LVSPSNGCPQSPLTSDASRQPV
TSGCSPCACGRS*ALGSSPSSGWRTRMSSGCWR
KETGCPSLISVHRSFIPS*PAAGTTTPVTGPAS
PSWCAASVTFIRWRRTLPWSKRGMLATEPPKSWS
PQPSRNPHPSPADLSTDPLRKPTSWLQSCSSRF
LRVCVPALLRSPALWSIHLPLTHCTPHLSTGTM
SSNATACG
RRTSSNPAAEKRPSSCGRLKRSKCGK
SWTNS
RSRWWRTTSGSGRRRSPWTPWFI*MISP
H*RQRRRSATWSSQGPHRSPRGWAHSPSSPQLT
WTGLMTWCTSMSWSWCGPCWSSRMSSVSCPPRAT
WWW*RMWG*PCGSSSGAWMISCLPCRHLHGQRS
RAPRNCSTKTWQSSSTRCGWHSRTP*PP*VRSA
RGRC*RLHTPWLWTPRTCSTLWTRPRFWPIWPTH
LQSDGGWGPPACVFRPCLPCTSPALLLVMWVFQ
GEGQGESPSLATLHDALSPPLPLAVLLRLQLDR
GDSGLWTQGDGDKDGSEGDCCCLATAP*ASLVHA
GGSWGWGGVTWCP*LYIWTWQADLGTKLFLSLP
LRPSDVP*CTEKLGRSFVLGVRQPVR*GMGLAF
LYSVY*NLFNVSLVWTDSMCPPEGGPGAQSRNKL
IGSPGTGCCVVNKPSIRGKKQRDAAKIGPWAKS
ALFLPLFLFLPLLSLAFPSFLTPPLSLPNPHSH
LHPSFLMCLHKHSFNFFLFDLWLN*NCPIC

Frame 1

SNLSALLLSHSLRSRCTPTCPADLPVLAAVPAH
LAVPEE*SLESAPPWDCNVPILAAA*EDVWGVR
APESSKVGHVTPA*RPCRAHGGGTSRCGKGGRAY
PQGLLL*QQLQSWEKLQTGQMHCPDGDPGDHHL
HPAERADRAQHPVG*VLWAEAEAHEVR*DPLAA
PTDDGG*GAGQV*VSARGSRVEV*PSNPLLARRL
HGEPEGGQDHAALFLPTAPERLHAALRQQGQRG
HGPAAGLPGAQAVLQGYAPQCT*QEVQLRAPRK
GSGAGLVFPKADAGELKAQTVPEDDPADLPAVRL
AQGGGVRHEVLQHSRRLRQHRPGDLPL*THSRM
EHYCGPGHWP*RDPPAD*SGRKAHLPGRVQADQ
VHQVPPAGGGPGSTSAGH*RCPPGLVHQNLIPSR
G*EHG*PHRRLLPAAG*APRLSHHPS*ERW*EA
EQPAPDPHAKPGGPAVPPLRELQHRVRHLRRDS
RRNPAKARRSTVWHCP*RCGPESYSWGRLFWGGL
*RCLHKSQRGENQCSCQDLQERLHSGQQGEVHE
RGSDHEEPRPPAHREADRHH*RGAHLDHHGIVS
LWGAGPLPGAEQELPEGAHPRAVLTADMQSHGLP
GEHQLRAQGHCCPEHPGGLP*VCEAGGLWSFPV
H*GRGLLQSLCDSSPHQMDVPRVH*LPTLHDSQ
*RLDVRRVHVGDPELWEAALLLAGEQGCHRGAGE
RRPAAQA*SLSTGPLYPHDPLLGLRPQ*PAPLH
RAGVQPQ*RLSDGEGHCHGAREECSLPNPQNLG
AHSLPGTPTQAQPT*VQTPSANQPPGSKAAVPGS
*GSVCQLSYAHQPYGVSISR*LTAHPTSPPAQC
LQTPQHA
GGGLHPTQQPRRGPAAVGG*KGQNAA
NPGQT
AEADGGGLPVAQAGGEVPGPHGLYE**VP
IDAREGGRLPGVHRAPTEAPEAGRTVHPAHS*P
GPD**PGVPQCHGAGAGRAGAQE*ALSAAPRGL
RGGGEECGADPAEAHRERG*SPAFLAVIFTDRDR
GHPETAQQRPGRAHQQDAAGTAERRDLPK*GVQ
EADADGFTHPGCGRQEPARRCGPGQGSGQSGPP
TCRVTEGGGHLPASSAPACHVPPLPCCWSCGSSR
GKAKGSHLPLPLCTTPSPHPYPWLYCSGCSWTE
GTLGYGHRVTVTKMAQRGTAAAWPLLPKPAWSM
QGAPGGGEVSHGAPSFIYGHGRPIWEPSYSFPFL
FGPQMSLDAQRSWGGALFWGSGSQ*DEGWAWHS
CTVYIEIYLM*VWSGLTACALLREDLGHSPGTS
*LGVQAQDAVLSTNQASGGRSREMRPR*DLGPNP
LSSCPSFSFFLYFPLLFPLFLLLLFLSPTPILI
CTLLFSCVCINILLTSFYLTCG*IKIVPF

Frame 2

LTCQPFYSATASGAVAHLPARPTYLYLPPSRLT
WRCPRSSRWSPRLPGTAMCRS*LLPERMSGVSE
PLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVR
ILKVCFYSNSFNPGKNFKLVKCTVQTEIREIITS
ILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLH
PQMTVGEVQDKYECLHVEAEWRYDLQIRYLPED
FMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEG
MALQLGCLELRRFFKDMPHNALDKKSNFELLEK
EVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYA
SLREEECVMKFFNTLAGFANIDQETYRCELIQGW
NITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIR
SIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLA
EAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKR
NSLPQIPMLNLEARRSHLSESCSIESDIYAEIP
DETLRRPGGPQYGIAREDVVLNRILGEGFFGEV
YEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMS
EAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYP
YGELGHYLERNKNSLKVLTLVLYSLQICKAMAY
LESINCVHRDIAVRNILVASPECVKLGDFGLSRY
IEDEDYYKASVTRLPIKWMSPESINFRRFTTAS
DVWMFAVCMWEILSFGKQPFFWLENKDVIGVLE
KGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFT
ELVCSLSDVYQMEKDIAMEQERNARYRTPKILE
PTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQV
PEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNV
FKRHSMR
EEDFIQPSSREEAQQLWEAEKVKMRQ
ILDKQ
QKQMVEDYQWLRQEEKSLDPMVYMNDKS
PLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANL
DRTDDLVYLNVMELVRAVLELKNELCQLPPEGY
VVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEI
EGTQKLLNKDLAELINKMRLAQQNAVTSLSEECK
RQMLTASHTLAVDAKNLLDAVDQAKVLANLAHP
PAE*RRVGATCLRLPPLPAMYLPCLAVGHVGLP
GGRPRGVTFPCHFARRPLPTPTPGCTAQAAAGQR
GLWAMDTG*R*QRWLRGGLLLPGHCSLSQPGPC
RGLLGVGRCHMVPLALYMDMAGRFGNQAIPFPS
SSALRCPLMHREAGEELCFGGQAASEMRDGPGIL
VQCILKFI*CEFGLD*QHVPS*GRTWGTVQEQA
NWESRHRMLCCQQTKHQGEEAERCGQDRTLGQI
RSLPAPLSLSSFTFPCFSLFSYSSSFSPQPPFSS
APFFSHVFA*TFF*LLSI*LVVELKLSHL

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