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Sequences

Sequence NM_000959

GCCCCGCAGTTTCCGCGCTAAGGGAACGAGTGCGCGGAGGGGACGAGCGGCTGGACCACAGCCGGCGCCCGATCAGGATCTCCGCGCTGGGATCGGTGGA ACTTGAGGCAGCGGCGGCGCGGGGCGCCATGGCACACCGAGCGGCTCCGTCTTCTGCTCCTCAGAGAGCCCGGCTGGCGGCCTGGGATGACAAGATGTCT GGACTGCAATCCTGCACAGTTTTGAGAGGGAGATGACTTGAGTGGTTGGCTTTTATCTCCACAACAATGTCCATGAACAATTCCAAACAGCTAGTGTCTC CTGCAGCTGCGCTTCTTTCAAACACAACCTGCCAGACGGAAAACCGGCTTTCCGTATTTTTTTCAGTAATCTTCATGACAGTGGGAATCTTGTCAAACAG CCTTGCCATCGCCATTCTCATGAAGGCATATCAGAGATTTAGACAGAAGTCCAAGGCATCGTTTCTGCTTTTGGCCAGTGGCCTGGTAATCACTGATTTC TTTGGCCATCTCATCAATGGAGCCATAGCAGTATTTGTATATGCTTCTGATAAAGAATGGATCCGCTTTGACCAATCAAATGTCCTTTGCAGTATTTTTG GTATCTGCATGGTGTTTTCTGGTCTGTGCCCACTTCTTCTAGGCAGTGTGATGGCCATTGAGCGGTGTATTGGAGTCACAAAACCAATATTTCATTCTAC GAAAATTACATCCAAACATGTGAAAATGATGTTAAGTGGTGTGTGCTTGTTTGCTGTTTTCATAGCTTTGCTGCCCATCCTTGGACATCGAGACTATAAA ATTCAGGCGTCGAGGACCTGGTGTTTCTACAACACAGAAGACATCAAAGACTGGGAAGATAGATTTTATCTTCTACTTTTTTCTTTTCTGGGGCTCTTAG CCCTTGGTGTTTCATTGTTGTGCAATGCAATCACAGGAATTACACTTTTAAGAGTTAAATTTAAAAGTCAGCAGCACAGACAAGGCAGATCTCATCATTT GGAAATGGTAATCCAGCTCCTGGCGATAATGTGTGTCTCCTGTATTTGTTGGAGCCCATTTCTGGTTACAATGGCCAACATTGGAATAAATGGAAATCAT TCTCTGGAAACCTGTGAAACAACACTTTTTGCTCTCCGAATGGCAACATGGAATCAAATCTTAGATCCTTGGGTATATATTCTTCTACGAAAGGCTGTCC TTAAGAATCTCTATAAGCTTGCCAGTCAATGCTGTGGAGTGCATGTCATCAGCTTACATATTTGGGAGCTTAGTTCCATTAAAAATTCCTTAAAGGTTGC TGCTATTTCTGAGTCACCAGTTGCAGAGAAATCAGCAAGCACCTAGCTTAATAGGACAGTAAATCTGTGTGGGGCTAGAACAAAATTAAGACATGTTTGG CAATATTTCAGTTAGTTAAATACCTGTAGCCTAACTGGAAAATTCAGGCTTCATCATGTAGTTTGAAGATACTATTGTCAGATTCAGGTTTTGAAATTTG TCAAATAAACAGGATAACTGTACATTTTTCACTTGTTTTTGCCAATGGGAGGTAGACACAATAAAATAATGCCATGGGAGTCACACTGAAAGCAATTTTG AGCTTATCTGTCTTATTTATGCTTTGAGTGAATCATCTGTTGAGGTCTAATGCCTTTACTTGGCCTATTTGCCAGAGAACATCTTAATGCAGCCTGCATA GTGAAATGGTTATTTTGAGATCACCGCTCTGTAGCTAACCCTTATAAACTAGGCTCAGTAAAATAAAGCACTCTTATTTTTTGATCTGGCCTATTTTGCC CCTCATTGTGTAGCCTCAATTAACACATGCATGGTCATGACACCCAGAATTCATGATGGTTTGTTATAACAACCTCTGCATATTCCAGGTCTGGCAGACA GGTTGCCTGACCCTGCAATCCTATCTAGAATGGGCCCATTCTTGTCATATTTGACAAATAGGACTGCCTACATTTATTATTATGAAGGTCGATTGTTGTT GGAAGTGTTTTTTCATGTCATAGATTAGCAATTTTCAAATAATTATTTTTTCTCTGAAAATTTTGTGTGTGATTGCACAATAAATAATTTTTAGAGAAAC AAAGGCTCTTTCTCAGCACATTGATGGGCAACTAGAATTACAGCAGTTTCAAAACTCTACCATGGATAATGCAAACAAACCGAAGCTACATGCCAATGAT AGGTGCAAAGAATATTGGCAAAAGGTGCTTTACCTTGAGCCATTATTTGTGTCAGAGAACAAAAGAAACAGAATCAATATATAAAATTCAAAGACTATCT GCAGCTAGTGTGTTTCTTCTTTACACACATATACACACAGACATCAGAAAATTCTGTTGAGAGCAGGTTCATTAAATTTGTAAGATGGCATATTCTAAAG CCTGTGCTACCAGTACTAAGAGGGGAAGACTGGCAATTTGCCAAGCACTTGGGGATTATTATAACAATTAACTAGGAGATCAAGAGATAATAATCTCTCC CCAAATTTTCCAATAATAATTGAGACTTTTTCTTTGCTTGTTTGTGTAATTCAACCAAAAGAATTTCAATACCCATTCAAATTGTCCTAGGTCTATCAGA AATTAGGGAAGGTAGTCCTGCTTTATAATAGGAAAATGTATTTCTGTATAAGAGTTCTTTGCTTTCATTAACTTGGATTCATTTAAAAATTAATCTTCCC TGTTAGGCTGATTTCAGATTCTCTAGGAAATCTGTGTAAGTAACCAGAAGACCTTTCAGATGGTTTATTTGCTTTCAGCAGAGAATTTATTTCATACAGT TACTTAAGAGTGTTGATGTCTTGTGAACAGAGATATAAGGAACCATTCTCCATCCTTCCTTATCATGCTGGGTACAATGCTTCTATGAATATTTCCATGT ATTTTGACTGGGGAGAGGCATGGAGAAGAAACTCTCATTCAGGGGCTCCAGGATCCTTCTCCTTGAGGCTTCTAAATAAATGGCAGAATTCTTGCTGTAT TGCCATGATGTCACCCTGGCCATGTGTACTGACTTGAGGAGATCTTGCAACATGGCCATGTGCAAGGCTTTAAGGAGTGAGAGAGATGTGTACATATCTT AGGAGGGTTATCTATGTTATCTGAGTATATGTTTGGGTAACCAAATTGGTCTTAAAAATGATGTTAACCCAAGAAGTAGACATCAAAAATTAAAAAAAAA AAAAGGAATGTGTTTTCATTGTTTTAAGTTTTTCTTCTGAGTAAAACAAAATTATAGAAAACAAATGCAACAATGTGCACATCTGACTTAAGAGTTTCAT TTCTGTTATTATATGTGTTGCATGTAGCTTGGCGATTTACTGTGTAATGAATAATAGACTGGAACATCTACCAATAACTTTCACATAAATGTTCAAAATA GAAGTGTATTTTTTCAGGTTTCTGGAAATAAATAGTAAAATAAATGGCACAAATAGTTTCAATAAATTTACCAATTTGAGTGTTTTCAGCTCTATTTCAA AACTCATAACTAATCTTCAGAATTACTGAATTTCCTTTTGAACTGGGTAAGGCATTATCCAAGCAACTTCACATACTATTTAAACATGATTTCTCGGTAA TTATATATTCTGGGCAAATAACATAAACATGTCAGGATTTTTACAGGTGTTAGTGAATTTTTCTAAAAAGATGAGACAAAAGCAAAAATATCACACATAG GTTTTTATGACTATGAATACAAAGATAATGCTGATTCACAATTAGCTATGGGTAAGTCCAAAACATCAGACCTTTTACTGATGGGTTAACTAGGTGAAAG AAATGGGCCCTTATTTTTTTTTTTCCCTAGAGGCAGAAAGTTACTTCTAATGATCTATATAGCTAAAACGAAAAATACCTGAAAGTTAATACATACATAT GTAGATATATTTTGTTATGTGATAAATGTTTCTTGTTTGCACACTTTTGGACTTGAGAAATCTGCTTTTGTTTTGTGCCTACTCTGAGTTTAGAACCCAA ATAAGAGGACTTGTTAAATATAGAGTGTACTTTTTGTTAAAACTATTGCTAGCTTCACCTGTATACCATCATTGTTCCAAATTAAATAACTGTTTTGGGT CAGAATATAAATGCTGGGAATATACATTTTATTACTTCTTAATCTGGGTGTCAAAGATTTTACCACCTGGTAAATAATGTTGGACTTCAACTTGTTACTG GCACATTTTAATAGTAGATGAAACATGTTTTTCTTGGTTATGTGAATAAATGTATGTTGTGCTCTTCATACTTGTTGGATTGTATAGAGATTAAATAGTG ATATGTATATTTTGTTGTTTGCTTTGGTATGCAACTCATGTAATTTTAGTGCTTTGACTAGCTTAAAACTTCAAACAAGTAATTTTATAATAAAGTTGGA CTAATGTTTTTCAAGAGTGATTATTTTTAGAAGGACCATATAAAACTTGAAACGCTTGAACCTAAACTCCCGTTTTATCTGCTACTGGATGAGAAGAATT TCAACTTAATTTCCATTATTACCTTTTGCTCTCCCACCCTGCCCAATCTTCTGTGATATCTTCTCTCTTTTACCTGTGTCTCAACTTACCTAGGCAAGTC ATAATTTAGATAGAAATCTGATTTCCCAAACCTCCAGGTTTAGATATATCATTCAGAAAAGCCTCAATGTGTCTGTAATAAGAAACAATCTCCAAATTAC AGCGCCATAAACTTCACAAAAGTTTGTATCTCCCACATGGTTCCTGTCCACTCTGAAGGGGAGCTCTGCTGTTGTAATCACTCAGAGAACTCAGGTGAAA AAACAGCCACCATTATATGTGGCTGTTTCTCAAACTACAGAGCATGGTGAATCACACACAGGCTGTTAGAATATCCATCTGGAGGCAACACACATTTGCA TACACTTCTCCAGCTAACATAAATAATGTGGCTTTACTAACTTCCCAGGGGGCAGCTAAGTGCAATACTATATGTTAGGAAAACGGAAACTAATTTGTAG ACAGCACTAATGATTTCCACATTAGGTAAAAAAAATTTTCATTCTTGTCTTCCTAATAGCATTTAAACAGAAACGATTTTTAAAAGTTGTTTTAAACATT TAGAAACATCATGGCATAGAAACATTTAGGACTCACTCTTTGTAAGTACTGACAAGCATGGTCTTGTAATCTGTAAAGATAAGGTAGAATAAATGAACTA AAAGAAATTTTAGATGACTAAAAGGACTATATAATAGAAAGAGGGAAATCTTGGTTCTTAAAAATTCAGGCAATTGAAACATTTCTGTATAATACCAAGC ATTGTTGCAGTATTGTCTGAAATGGTTGCTTTTCTAATAAATGAAAATGACTAAAATGTA

refseq_PTGFR.F2 (forward primer)
refseq_PTGFR.R2 (reverse primer)
Single exon skipping

Frame 0

APQFPR*GNECAEGTSGWTTAGARSGSPRWDRW NLRQRRRGAPWHTERLRLLLLREPGWRPGMTRCL DCNPAQF*EGDDLSGWLLSPQQCP*TIPNS*CL LQLRFFQTQPARRKTGFPYFFQ*SS*QWESCQT ALPSPFS*RHIRDLDRSPRHRFCFWPVAW*SLIS LAISSMEP*QYLYMLLIKNGSALTNQMSFAVFL VSAWCFLVCAHFF*AV*WPLSGVLESQNQYFIL RKLHPNM*K*C*VVCACLLFS*LCCPSLDIETIK FRRRGPGVSTTQKTSKTGKIDFIFYFFLFWGS* PLVFHCCAMQSQELHF*ELNLKVSSTDKADLII WKW*SSSWR*CVSPVFVGAHFWLQWPTLE*MEII LWKPVKQHFLLSEWQHGIKS*ILGYIFFYERLS LRISISLPVNAVECMSSAYIFGSLVPLKIP*RL LLFLSHQLQRNQQAPSLIGQ*ICVGLEQN*DMFG NISVS*IPVA*LENSGFIM*FEDTIVRFRF*NL SNKQDNCTFFTCFCQWEVDTIK*CHGSHTESNF ELICLIYALSESSVEV*CLYLAYLPENILMQPA* *NGYFEITAL*LTLIN*AQ*NKALLFFDLAYFA PHCVASINTCMVMTPRIHDGLL*QPLHIPGLAD RLPDPAILSRMGPFLSYLTNRTAYIYYYEGRLLL EVFFHVID*QFSNNYFFSENFVCDCTINNF*RN KGSFSAH*WATRITAVSKLYHG*CKQTEATCQ* *VQRILAKGALP*AIICVREQKKQNQYIKFKDYL QLVCFFFTHIYTQTSENSVESRFIKFVRWHILK PVLPVLRGEDWQFAKHLGIIITIN*EIKR**SL PKFSNNN*DFFFACLCNSTKRISIPIQIVLGLSE IREGSPAL**ENVFLYKSSLLSLTWIHLKINLP C*ADFRFSRKSV*VTRRPFRWFICFQQRIYFIQ LLKSVDVL*TEI*GTILHPSLSCWVQCFYEYFHV F*LGRGMEKKLSFRGSRILLLEASK*MAEFLLY CHDVTLAMCTDLRRSCNMAMCKALRSERDVYIS *EGYLCYLSICLGNQIGLKNDVNPRSRHQKLKKK KGMCFHCFKFFF*VKQNYRKQMQQCAHLT*EFH FCYYMCCM*LGDLLCNE**TGTSTNNFHINVQN RSVFFQVSGNK**NKWHK*FQ*IYQFECFQLYFK THN*SSELLNFLLNWVRHYPSNFTYYLNMISR* LYILGK*HKHVRIFTGVSEFF*KDETKAKISHI GFYDYEYKDNADSQLAMGKSKTSDLLLMG*LGER NGPLFFFFPRGRKLLLMIYIAKTKNT*KLIHTY VDIFCYVINVSCLHTFGLEKSAFVLCLL*V*NP NKRTC*I*SVLFVKTIASFTCIPSLFQIK*LFWV RI*MLGIYILLLLNLGVKDFTTW*IMLDFNLLL AHFNSR*NMFFLVM*INVCCALHTCWIV*RLNS DMYILLFALVCNSCNFSALTSLKLQTSNFIIKLD *CFSRVIIFRRTI*NLKRLNLNSRFICYWMRRI ST*FPLLPFALPPCPIFCDIFSLLPVSQLT*AS HNLDRNLISQTSRFRYIIQKSLNVSVIRNNLQIT AP*TSQKFVSPTWFLSTLKGSSAVVITQRTQVK KQPPLYVAVSQTTEHGESHTGC*NIHLEATHIC IHFSS*HK*CGFTNFPGGS*VQYYMLGKRKLICR QH**FPH*VKKIFILVFLIAFKQKRFLKVVLNI *KHHGIETFRTHSL*VLTSMVL*SVKIR*NK*T KRNFR*LKGLYNRKREILVLKNSGN*NISV*YQA LLQYCLKWLLF**MKMTKM

Frame 1

PRSFRAKGTSARRGRAAGPQPAPDQDLRAGIGG T*GSGGAGRHGTPSGSVFCSSESPAGGLG*QDV WTAILHSFEREMT*VVGFYLHNNVHEQFQTASVS CSCASFKHNLPDGKPAFRIFFSNLHDSGNLVKQ PCHRHSHEGISEI*TEVQGIVSAFGQWPGNH*F LWPSHQWSHSSICICF**RMDPL*PIKCPLQYFW YLHGVFWSVPTSSRQCDGH*AVYWSHKTNISFY ENYIQTCENDVKWCVLVCCFHSFAAHPWTSRL* NSGVEDLVFLQHRRHQRLGR*ILSSTFFFSGALS PWCFIVVQCNHRNYTFKS*I*KSAAQTRQISSF GNGNPAPGDNVCLLYLLEPISGYNGQHWNKWKS FSGNL*NNTFCSPNGNMESNLRSLGIYSSTKGCP *ESL*ACQSMLWSACHQLTYLGA*FH*KFLKGC CYF*VTSCREISKHLA**DSKSVWG*NKIKTCL AIFQLVKYL*PNWKIQASSCSLKILLSDSGFEIC QINRITVHFSLVFANGR*TQ*NNAMGVTLKAIL SLSVLFML*VNHLLRSNAFTWPICQRTS*CSLH SEMVILRSPLCS*PL*TRLSKIKHSYFLIWPILP LIV*PQLTHAWS*HPEFMMVCYNNLCIFQVWQT GCLTLQSYLEWAHSCHI*QIGLPTFIIMKVDCC WKCFFMS*ISNFQIIIFSLKILCVIAQ*IIFRET KALSQHIDGQLELQQFQNSTMDNANKPKLHAND RCKEYWQKVLYLEPLFVSENKRNRINI*NSKTI CS*CVSSLHTYTHRHQKILLRAGSLNL*DGIF*S LCYQY*EGKTGNLPSTWGLL*QLTRRSRDNNLS PNFPIIIETFSLLVCVIQPKEFQYPFKLS*VYQ KLGKVVLLYNRKMYFCIRVLCFH*LGFI*KLIFP VRLISDSLGNLCK*PEDLSDGLFAFSREFISYS YLRVLMSCEQRYKEPFSILPYHAGYNASMNISM YFDWGEAWRRNSHSGAPGSFSLRLLNKWQNSCCI AMMSPWPCVLT*GDLATWPCARL*GVREMCTYL RRVIYVI*VYVWVTKLVLKMMLTQEVDIKN*KK KKECVFIVLSFSSE*NKIIENKCNNVHI*LKSFI SVIICVACSLAIYCVMNNRLEHLPITFT*MFKI EVYFFRFLEINSKINGTNSFNKFTNLSVFSSIS KLITNLQNY*ISF*TG*GIIQATSHTI*T*FLGN YIFWANNINMSGFLQVLVNFSKKMRQKQKYHT* VFMTMNTKIMLIHN*LWVSPKHQTFY*WVN*VK EMGPYFFFSLEAESYF**SI*LKRKIPES*YIHM *IYFVM**MFLVCTLLDLRNLLLFCAYSEFRTQ IRGLVKYRVYFLLKLLLASPVYHHCSKLNNCFG SEYKCWEYTFYYFLIWVSKILPPGK*CWTSTCYW HILIVDETCFSWLCE*MYVVLFILVGLYRD*IV ICIFCCLLWYATHVILVL*LA*NFKQVIL**SW TNVFQE*LFLEGPYKT*NA*T*TPVLSATG*EEF QLNFHYYLLLSHPAQSSVISSLFYLCLNLPRQV II*IEI*FPKPPGLDISFRKASMCL**ETISKL QRHKLHKSLYLPHGSCPL*RGALLL*SLRELR*K NSHHYMWLFLKLQSMVNHTQAVRISIWRQHTFA YTSPANINNVALLTSQGAAKCNTIC*ENGN*FV DSTNDFHIR*KKFSFLSS**HLNRNDF*KLF*TF RNIMA*KHLGLTLCKY*QAWSCNL*R*GRINEL KEILDD*KDYIIERGKSWFLKIQAIETFLYNTK HCCSIV*NGCFSNK*K*LKC

Frame 2

PAVSALRERVRGGDERLDHSRRPIRISALGSVE LEAAAARGAMAHRAAPSSAPQRARLAAWDDKMS GLQSCTVLRGR*LEWLAFISTTMSMNNSKQLVS PAAALLSNTTCQTENRLSVFFSVIFMTVGILSNS LAIAILMKAYQRFRQKSKASFLLLASGLVITDF FGHLINGAIAVFVYASDKEWIRFDQSNVLCSIF GICMVFSGLCPLLLGSVMAIERCIGVTKPIFHST KITSKHVKMMLSGVCLFAVFIALLPILGHRDYK IQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLL ALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHL EMVIQLLAIMCVSCICWSPFLVTMANIGINGNH SLETCETTLFALRMATWNQILDPWVYILLRKAV LKNLYKLASQCCGVHVISLHIWELSSIKNSLKVA AISESPVAEKSAST*LNRTVNLCGARTKLRHVW QYFS*LNTCSLTGKFRLHHVV*RYYCQIQVLKF VK*TG*LYIFHLFLPMGGRHNKIMPWESH*KQF* AYLSYLCFE*IIC*GLMPLLGLFAREHLNAACI VKWLF*DHRSVANPYKLGSVK*STLIF*SGLFC PSLCSLN*HMHGHDTQNS*WFVITTSAYSRSGRQ VA*PCNPI*NGPILVIFDK*DCLHLLL*RSIVV GSVFSCHRLAIFK*LFFL*KFCV*LHNK*FLEK QRLFLSTLMGN*NYSSFKTLPWIMQTNRSYMPMI GAKNIGKRCFTLSHYLCQRTKETESIYKIQRLS AASVFLLYTHIHTDIRKFC*EQVH*ICKMAYSK ACATSTKRGRLAICQALGDYYNN*LGDQEIIISP QIFQ**LRLFLCLFV*FNQKNFNTHSNCPRSIR N*GR*SCFIIGKCISV*EFFAFINLDSFKN*SS LLG*FQIL*EICVSNQKTFQMVYLLSAENLFHTV T*EC*CLVNRDIRNHSPSFLIMLGTMLL*IFPC ILTGERHGEETLIQGLQDPSP*GF*INGRILAV LP*CHPGHVY*LEEILQHGHVQGFKE*ERCVHIL GGLSMLSEYMFG*PNWS*K*C*PKK*TSKIKKK KRNVFSLF*VFLLSKTKL*KTNATMCTSDLRVS FLLLYVLHVAWRFTV**IIDWNIYQ*LSHKCSK* KCIFSGFWK*IVK*MAQIVSINLPI*VFSALFQ NS*LIFRITEFPFELGKALSKQLHILFKHDFSV IIYSGQIT*TCQDFYRC**IFLKR*DKSKNITHR FL*L*IQR*C*FTISYG*VQNIRPFTDGLTR*K KWALIFFFP*RQKVTSNDLYS*NEKYLKVNTYI CRYILLCDKCFLFAHFWT*EICFCFVPTLSLEPK *EDLLNIECTFC*NYC*LHLYTIIVPN*ITVLG QNINAGNIHFITS*SGCQRFYHLVNNVGLQLVT GTF***MKHVFLGYVNKCMLCSSYLLDCIEIK** YVYFVVCFGMQLM*F*CFD*LKTSNK*FYNKVG LMFFKSDYF*KDHIKLETLEPKLPFYLLLDEKN FNLISIITFCSPTLPNLL*YLLSFTCVSTYLGKS *FR*KSDFPNLQV*IYHSEKPQCVCNKKQSPNY SAINFTKVCISHMVPVHSEGELCCCNHSENSGE KTATIICGCFSNYRAW*ITHRLLEYPSGGNTHLH TLLQLT*IMWLY*LPRGQLSAILYVRKTETNL* TALMISTLGKKNFHSCLPNSI*TETIFKSCFKH LETSWHRNI*DSLFVSTDKHGLVICKDKVE*MN* KKF*MTKRTI**KEGNLGS*KFRQLKHFCIIPS IVAVLSEMVAFLINEND*NV

Sequence NM_001039585

GCCCCGCAGTTTCCGCGCTAAGGGAACGAGTGCGCGGAGGGGACGAGCGGCTGGACCACAGCCGGCGCCCGATCAGGATCTCCGCGCTGGGATCGGTGGA ACTTGAGGCAGCGGCGGCGCGGGGCGCCATGGCACACCGAGCGGCTCCGTCTTCTGCTCCTCAGAGAGCCCGGCTGGCGGCCTGGGATGACAAGATGTCT GGACTGCAATCCTGCACAGTTTTGAGAGGGAGATGACTTGAGTGGTTGGCTTTTATCTCCACAACAATGTCCATGAACAATTCCAAACAGCTAGTGTCTC CTGCAGCTGCGCTTCTTTCAAACACAACCTGCCAGACGGAAAACCGGCTTTCCGTATTTTTTTCAGTAATCTTCATGACAGTGGGAATCTTGTCAAACAG CCTTGCCATCGCCATTCTCATGAAGGCATATCAGAGATTTAGACAGAAGTCCAAGGCATCGTTTCTGCTTTTGGCCAGTGGCCTGGTAATCACTGATTTC TTTGGCCATCTCATCAATGGAGCCATAGCAGTATTTGTATATGCTTCTGATAAAGAATGGATCCGCTTTGACCAATCAAATGTCCTTTGCAGTATTTTTG GTATCTGCATGGTGTTTTCTGGTCTGTGCCCACTTCTTCTAGGCAGTGTGATGGCCATTGAGCGGTGTATTGGAGTCACAAAACCAATATTTCATTCTAC GAAAATTACATCCAAACATGTGAAAATGATGTTAAGTGGTGTGTGCTTGTTTGCTGTTTTCATAGCTTTGCTGCCCATCCTTGGACATCGAGACTATAAA ATTCAGGCGTCGAGGACCTGGTGTTTCTACAACACAGAAGACATCAAAGACTGGGAAGATAGATTTTATCTTCTACTTTTTTCTTTTCTGGGGCTCTTAG CCCTTGGTGTTTCATTGTTGTGCAATGCAATCACAGGAATTACACTTTTAAGAGTTAAATTTAAAAGTCAGCAGCACAGACAAGGCAGATCTCATCATTT GGAAATGGTAATCCAGCTCCTGGCGATAATGTGTGTCTCCTGTATTTGTTGGAGCCCATTTCTGGGATACAGAATAATTTTGAATGGGAAAGAGAAATAT AAAGTATATGAAGAGCAAAGTGATTTCTTACATAGGTTACAATGGCCAACATTGGAATAAATGGAAATCATTCTCTGGAAACCTGTGAAACAACACTTTT TGCTCTCCGAATGGCAACATGGAATCAAATCTTAGATCCTTGGGTATATATTCTTCTACGAAAGGCTGTCCTTAAGAATCTCTATAAGCTTGCCAGTCAA TGCTGTGGAGTGCATGTCATCAGCTTACATATTTGGGAGCTTAGTTCCATTAAAAATTCCTTAAAGGTTGCTGCTATTTCTGAGTCACCAGTTGCAGAGA AATCAGCAAGCACCTAGCTTAATAGGACAGTAAATCTGTGTGGGGCTAGAACAAAATTAAGACATGTTTGGCAATATTTCAGTTAGTTAAATACCTGTAG CCTAACTGGAAAATTCAGGCTTCATCATGTAGTTTGAAGATACTATTGTCAGATTCAGGTTTTGAAATTTGTCAAATAAACAGGATAACTGTACATTTTT CACTTGTTTTTGCCAATGGGAGGTAGACACAATAAAATAATGCCATGGGAGTCACACTGAAAGCAATTTTGAGCTTATCTGTCTTATTTATGCTTTGAGT GAATCATCTGTTGAGGTCTAATGCCTTTACTTGGCCTATTTGCCAGAGAACATCTTAATGCAGCCTGCATAGTGAAATGGTTATTTTGAGATCACCGCTC TGTAGCTAACCCTTATAAACTAGGCTCAGTAAAATAAAGCACTCTTATTTTTTGATCTGGCCTATTTTGCCCCTCATTGTGTAGCCTCAATTAACACATG CATGGTCATGACACCCAGAATTCATGATGGTTTGTTATAACAACCTCTGCATATTCCAGGTCTGGCAGACAGGTTGCCTGACCCTGCAATCCTATCTAGA ATGGGCCCATTCTTGTCATATTTGACAAATAGGACTGCCTACATTTATTATTATGAAGGTCGATTGTTGTTGGAAGTGTTTTTTCATGTCATAGATTAGC AATTTTCAAATAATTATTTTTTCTCTGAAAATTTTGTGTGTGATTGCACAATAAATAATTTTTAGAGAAACAAAGGCTCTTTCTCAGCACATTGATGGGC AACTAGAATTACAGCAGTTTCAAAACTCTACCATGGATAATGCAAACAAACCGAAGCTACATGCCAATGATAGGTGCAAAGAATATTGGCAAAAGGTGCT TTACCTTGAGCCATTATTTGTGTCAGAGAACAAAAGAAACAGAATCAATATATAAAATTCAAAGACTATCTGCAGCTAGTGTGTTTCTTCTTTACACACA TATACACACAGACATCAGAAAATTCTGTTGAGAGCAGGTTCATTAAATTTGTAAGATGGCATATTCTAAAGCCTGTGCTACCAGTACTAAGAGGGGAAGA CTGGCAATTTGCCAAGCACTTGGGGATTATTATAACAATTAACTAGGAGATCAAGAGATAATAATCTCTCCCCAAATTTTCCAATAATAATTGAGACTTT TTCTTTGCTTGTTTGTGTAATTCAACCAAAAGAATTTCAATACCCATTCAAATTGTCCTAGGTCTATCAGAAATTAGGGAAGGTAGTCCTGCTTTATAAT AGGAAAATGTATTTCTGTATAAGAGTTCTTTGCTTTCATTAACTTGGATTCATTTAAAAATTAATCTTCCCTGTTAGGCTGATTTCAGATTCTCTAGGAA ATCTGTGTAAGTAACCAGAAGACCTTTCAGATGGTTTATTTGCTTTCAGCAGAGAATTTATTTCATACAGTTACTTAAGAGTGTTGATGTCTTGTGAACA GAGATATAAGGAACCATTCTCCATCCTTCCTTATCATGCTGGGTACAATGCTTCTATGAATATTTCCATGTATTTTGACTGGGGAGAGGCATGGAGAAGA AACTCTCATTCAGGGGCTCCAGGATCCTTCTCCTTGAGGCTTCTAAATAAATGGCAGAATTCTTGCTGTATTGCCATGATGTCACCCTGGCCATGTGTAC TGACTTGAGGAGATCTTGCAACATGGCCATGTGCAAGGCTTTAAGGAGTGAGAGAGATGTGTACATATCTTAGGAGGGTTATCTATGTTATCTGAGTATA TGTTTGGGTAACCAAATTGGTCTTAAAAATGATGTTAACCCAAGAAGTAGACATCAAAAATTAAAAAAAAAAAAAGGAATGTGTTTTCATTGTTTTAAGT TTTTCTTCTGAGTAAAACAAAATTATAGAAAACAAATGCAACAATGTGCACATCTGACTTAAGAGTTTCATTTCTGTTATTATATGTGTTGCATGTAGCT TGGCGATTTACTGTGTAATGAATAATAGACTGGAACATCTACCAATAACTTTCACATAAATGTTCAAAATAGAAGTGTATTTTTTCAGGTTTCTGGAAAT AAATAGTAAAATAAATGGCACAAATAGTTTCAATAAATTTACCAATTTGAGTGTTTTCAGCTCTATTTCAAAACTCATAACTAATCTTCAGAATTACTGA ATTTCCTTTTGAACTGGGTAAGGCATTATCCAAGCAACTTCACATACTATTTAAACATGATTTCTCGGTAATTATATATTCTGGGCAAATAACATAAACA TGTCAGGATTTTTACAGGTGTTAGTGAATTTTTCTAAAAAGATGAGACAAAAGCAAAAATATCACACATAGGTTTTTATGACTATGAATACAAAGATAAT GCTGATTCACAATTAGCTATGGGTAAGTCCAAAACATCAGACCTTTTACTGATGGGTTAACTAGGTGAAAGAAATGGGCCCTTATTTTTTTTTTTCCCTA GAGGCAGAAAGTTACTTCTAATGATCTATATAGCTAAAACGAAAAATACCTGAAAGTTAATACATACATATGTAGATATATTTTGTTATGTGATAAATGT TTCTTGTTTGCACACTTTTGGACTTGAGAAATCTGCTTTTGTTTTGTGCCTACTCTGAGTTTAGAACCCAAATAAGAGGACTTGTTAAATATAGAGTGTA CTTTTTGTTAAAACTATTGCTAGCTTCACCTGTATACCATCATTGTTCCAAATTAAATAACTGTTTTGGGTCAGAATATAAATGCTGGGAATATACATTT TATTACTTCTTAATCTGGGTGTCAAAGATTTTACCACCTGGTAAATAATGTTGGACTTCAACTTGTTACTGGCACATTTTAATAGTAGATGAAACATGTT TTTCTTGGTTATGTGAATAAATGTATGTTGTGCTCTTCATACTTGTTGGATTGTATAGAGATTAAATAGTGATATGTATATTTTGTTGTTTGCTTTGGTA TGCAACTCATGTAATTTTAGTGCTTTGACTAGCTTAAAACTTCAAACAAGTAATTTTATAATAAAGTTGGACTAATGTTTTTCAAGAGTGATTATTTTTA GAAGGACCATATAAAACTTGAAACGCTTGAACCTAAACTCCCGTTTTATCTGCTACTGGATGAGAAGAATTTCAACTTAATTTCCATTATTACCTTTTGC TCTCCCACCCTGCCCAATCTTCTGTGATATCTTCTCTCTTTTACCTGTGTCTCAACTTACCTAGGCAAGTCATAATTTAGATAGAAATCTGATTTCCCAA ACCTCCAGGTTTAGATATATCATTCAGAAAAGCCTCAATGTGTCTGTAATAAGAAACAATCTCCAAATTACAGCGCCATAAACTTCACAAAAGTTTGTAT CTCCCACATGGTTCCTGTCCACTCTGAAGGGGAGCTCTGCTGTTGTAATCACTCAGAGAACTCAGGTGAAAAAACAGCCACCATTATATGTGGCTGTTTC TCAAACTACAGAGCATGGTGAATCACACACAGGCTGTTAGAATATCCATCTGGAGGCAACACACATTTGCATACACTTCTCCAGCTAACATAAATAATGT GGCTTTACTAACTTCCCAGGGGGCAGCTAAGTGCAATACTATATGTTAGGAAAACGGAAACTAATTTGTAGACAGCACTAATGATTTCCACATTAGGTAA AAAAAATTTTCATTCTTGTCTTCCTAATAGCATTTAAACAGAAACGATTTTTAAAAGTTGTTTTAAACATTTAGAAACATCATGGCATAGAAACATTTAG GACTCACTCTTTGTAAGTACTGACAAGCATGGTCTTGTAATCTGTAAAGATAAGGTAGAATAAATGAACTAAAAGAAATTTTAGATGACTAAAAGGACTA TATAATAGAAAGAGGGAAATCTTGGTTCTTAAAAATTCAGGCAATTGAAACATTTCTGTATAATACCAAGCATTGTTGCAGTATTGTCTGAAATGGTTGC TTTTCTAATAAATGAAAATGACTAAAATGTA

refseq_PTGFR.F2 (forward primer)
refseq_PTGFR.R2 (reverse primer)
Single exon skipping

Frame 0

APQFPR*GNECAEGTSGWTTAGARSGSPRWDRW NLRQRRRGAPWHTERLRLLLLREPGWRPGMTRCL DCNPAQF*EGDDLSGWLLSPQQCP*TIPNS*CL LQLRFFQTQPARRKTGFPYFFQ*SS*QWESCQT ALPSPFS*RHIRDLDRSPRHRFCFWPVAW*SLIS LAISSMEP*QYLYMLLIKNGSALTNQMSFAVFL VSAWCFLVCAHFF*AV*WPLSGVLESQNQYFIL RKLHPNM*K*C*VVCACLLFS*LCCPSLDIETIK FRRRGPGVSTTQKTSKTGKIDFIFYFFLFWGS* PLVFHCCAMQSQELHF*ELNLKVSSTDKADLII WKW*SSSWR*CVSPVFVGAHFWDTE*F*MGKRNI KYMKSKVISYIGYNGQHWNKWKSFSGNL*NNTF CSPNGNMESNLRSLGIYSSTKGCP*ESL*ACQS MLWSACHQLTYLGA*FH*KFLKGCCYF*VTSCRE ISKHLA**DSKSVWG*NKIKTCLAIFQLVKYL* PNWKIQASSCSLKILLSDSGFEICQINRITVHF SLVFANGR*TQ*NNAMGVTLKAILSLSVLFML*V NHLLRSNAFTWPICQRTS*CSLHSEMVILRSPL CS*PL*TRLSKIKHSYFLIWPILPLIV*PQLTH AWS*HPEFMMVCYNNLCIFQVWQTGCLTLQSYLE WAHSCHI*QIGLPTFIIMKVDCCWKCFFMS*IS NFQIIIFSLKILCVIAQ*IIFRETKALSQHIDG QLELQQFQNSTMDNANKPKLHANDRCKEYWQKVL YLEPLFVSENKRNRINI*NSKTICS*CVSSLHT YTHRHQKILLRAGSLNL*DGIF*SLCYQY*EGK TGNLPSTWGLL*QLTRRSRDNNLSPNFPIIIETF SLLVCVIQPKEFQYPFKLS*VYQKLGKVVLLYN RKMYFCIRVLCFH*LGFI*KLIFPVRLISDSLG NLCK*PEDLSDGLFAFSREFISYSYLRVLMSCEQ RYKEPFSILPYHAGYNASMNISMYFDWGEAWRR NSHSGAPGSFSLRLLNKWQNSCCIAMMSPWPCV LT*GDLATWPCARL*GVREMCTYLRRVIYVI*VY VWVTKLVLKMMLTQEVDIKN*KKKKECVFIVLS FSSE*NKIIENKCNNVHI*LKSFISVIICVACS LAIYCVMNNRLEHLPITFT*MFKIEVYFFRFLEI NSKINGTNSFNKFTNLSVFSSISKLITNLQNY* ISF*TG*GIIQATSHTI*T*FLGNYIFWANNIN MSGFLQVLVNFSKKMRQKQKYHT*VFMTMNTKIM LIHN*LWVSPKHQTFY*WVN*VKEMGPYFFFSL EAESYF**SI*LKRKIPES*YIHM*IYFVM**M FLVCTLLDLRNLLLFCAYSEFRTQIRGLVKYRVY FLLKLLLASPVYHHCSKLNNCFGSEYKCWEYTF YYFLIWVSKILPPGK*CWTSTCYWHILIVDETC FSWLCE*MYVVLFILVGLYRD*IVICIFCCLLWY ATHVILVL*LA*NFKQVIL**SWTNVFQE*LFL EGPYKT*NA*T*TPVLSATG*EEFQLNFHYYLL LSHPAQSSVISSLFYLCLNLPRQVII*IEI*FPK PPGLDISFRKASMCL**ETISKLQRHKLHKSLY LPHGSCPL*RGALLL*SLRELR*KNSHHYMWLF LKLQSMVNHTQAVRISIWRQHTFAYTSPANINNV ALLTSQGAAKCNTIC*ENGN*FVDSTNDFHIR* KKFSFLSS**HLNRNDF*KLF*TFRNIMA*KHL GLTLCKY*QAWSCNL*R*GRINELKEILDD*KDY IIERGKSWFLKIQAIETFLYNTKHCCSIV*NGC FSNK*K*LKC

Frame 1

PRSFRAKGTSARRGRAAGPQPAPDQDLRAGIGG T*GSGGAGRHGTPSGSVFCSSESPAGGLG*QDV WTAILHSFEREMT*VVGFYLHNNVHEQFQTASVS CSCASFKHNLPDGKPAFRIFFSNLHDSGNLVKQ PCHRHSHEGISEI*TEVQGIVSAFGQWPGNH*F LWPSHQWSHSSICICF**RMDPL*PIKCPLQYFW YLHGVFWSVPTSSRQCDGH*AVYWSHKTNISFY ENYIQTCENDVKWCVLVCCFHSFAAHPWTSRL* NSGVEDLVFLQHRRHQRLGR*ILSSTFFFSGALS PWCFIVVQCNHRNYTFKS*I*KSAAQTRQISSF GNGNPAPGDNVCLLYLLEPISGIQNNFEWEREI *SI*RAK*FLT*VTMANIGINGNHSLETCETTLF ALRMATWNQILDPWVYILLRKAVLKNLYKLASQ CCGVHVISLHIWELSSIKNSLKVAAISESPVAE KSAST*LNRTVNLCGARTKLRHVWQYFS*LNTCS LTGKFRLHHVV*RYYCQIQVLKFVK*TG*LYIF HLFLPMGGRHNKIMPWESH*KQF*AYLSYLCFE *IIC*GLMPLLGLFAREHLNAACIVKWLF*DHRS VANPYKLGSVK*STLIF*SGLFCPSLCSLN*HM HGHDTQNS*WFVITTSAYSRSGRQVA*PCNPI* NGPILVIFDK*DCLHLLL*RSIVVGSVFSCHRLA IFK*LFFL*KFCV*LHNK*FLEKQRLFLSTLMG N*NYSSFKTLPWIMQTNRSYMPMIGAKNIGKRC FTLSHYLCQRTKETESIYKIQRLSAASVFLLYTH IHTDIRKFC*EQVH*ICKMAYSKACATSTKRGR LAICQALGDYYNN*LGDQEIIISPQIFQ**LRL FLCLFV*FNQKNFNTHSNCPRSIRN*GR*SCFII GKCISV*EFFAFINLDSFKN*SSLLG*FQIL*E ICVSNQKTFQMVYLLSAENLFHTVT*EC*CLVN RDIRNHSPSFLIMLGTMLL*IFPCILTGERHGEE TLIQGLQDPSP*GF*INGRILAVLP*CHPGHVY *LEEILQHGHVQGFKE*ERCVHILGGLSMLSEY MFG*PNWS*K*C*PKK*TSKIKKKKRNVFSLF*V FLLSKTKL*KTNATMCTSDLRVSFLLLYVLHVA WRFTV**IIDWNIYQ*LSHKCSK*KCIFSGFWK *IVK*MAQIVSINLPI*VFSALFQNS*LIFRITE FPFELGKALSKQLHILFKHDFSVIIYSGQIT*T CQDFYRC**IFLKR*DKSKNITHRFL*L*IQR* C*FTISYG*VQNIRPFTDGLTR*KKWALIFFFP* RQKVTSNDLYS*NEKYLKVNTYICRYILLCDKC FLFAHFWT*EICFCFVPTLSLEPK*EDLLNIEC TFC*NYC*LHLYTIIVPN*ITVLGQNINAGNIHF ITS*SGCQRFYHLVNNVGLQLVTGTF***MKHV FLGYVNKCMLCSSYLLDCIEIK**YVYFVVCFG MQLM*F*CFD*LKTSNK*FYNKVGLMFFKSDYF* KDHIKLETLEPKLPFYLLLDEKNFNLISIITFC SPTLPNLL*YLLSFTCVSTYLGKS*FR*KSDFP NLQV*IYHSEKPQCVCNKKQSPNYSAINFTKVCI SHMVPVHSEGELCCCNHSENSGEKTATIICGCF SNYRAW*ITHRLLEYPSGGNTHLHTLLQLT*IM WLY*LPRGQLSAILYVRKTETNL*TALMISTLGK KNFHSCLPNSI*TETIFKSCFKHLETSWHRNI* DSLFVSTDKHGLVICKDKVE*MN*KKF*MTKRT I**KEGNLGS*KFRQLKHFCIIPSIVAVLSEMVA FLINEND*NV

Frame 2

PAVSALRERVRGGDERLDHSRRPIRISALGSVE LEAAAARGAMAHRAAPSSAPQRARLAAWDDKMS GLQSCTVLRGR*LEWLAFISTTMSMNNSKQLVS PAAALLSNTTCQTENRLSVFFSVIFMTVGILSNS LAIAILMKAYQRFRQKSKASFLLLASGLVITDF FGHLINGAIAVFVYASDKEWIRFDQSNVLCSIF GICMVFSGLCPLLLGSVMAIERCIGVTKPIFHST KITSKHVKMMLSGVCLFAVFIALLPILGHRDYK IQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLL ALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHL EMVIQLLAIMCVSCICWSPFLGYRIILNGKEKY KVYEEQSDFLHRLQWPTLE*MEIILWKPVKQHF LLSEWQHGIKS*ILGYIFFYERLSLRISISLPVN AVECMSSAYIFGSLVPLKIP*RLLLFLSHQLQR NQQAPSLIGQ*ICVGLEQN*DMFGNISVS*IPV A*LENSGFIM*FEDTIVRFRF*NLSNKQDNCTFF TCFCQWEVDTIK*CHGSHTESNFELICLIYALS ESSVEV*CLYLAYLPENILMQPA**NGYFEITA L*LTLIN*AQ*NKALLFFDLAYFAPHCVASINTC MVMTPRIHDGLL*QPLHIPGLADRLPDPAILSR MGPFLSYLTNRTAYIYYYEGRLLLEVFFHVID* QFSNNYFFSENFVCDCTINNF*RNKGSFSAH*WA TRITAVSKLYHG*CKQTEATCQ**VQRILAKGA LP*AIICVREQKKQNQYIKFKDYLQLVCFFFTH IYTQTSENSVESRFIKFVRWHILKPVLPVLRGED WQFAKHLGIIITIN*EIKR**SLPKFSNNN*DF FFACLCNSTKRISIPIQIVLGLSEIREGSPAL* *ENVFLYKSSLLSLTWIHLKINLPC*ADFRFSRK SV*VTRRPFRWFICFQQRIYFIQLLKSVDVL*T EI*GTILHPSLSCWVQCFYEYFHVF*LGRGMEK KLSFRGSRILLLEASK*MAEFLLYCHDVTLAMCT DLRRSCNMAMCKALRSERDVYIS*EGYLCYLSI CLGNQIGLKNDVNPRSRHQKLKKKKGMCFHCFK FFF*VKQNYRKQMQQCAHLT*EFHFCYYMCCM*L GDLLCNE**TGTSTNNFHINVQNRSVFFQVSGN K**NKWHK*FQ*IYQFECFQLYFKTHN*SSELL NFLLNWVRHYPSNFTYYLNMISR*LYILGK*HKH VRIFTGVSEFF*KDETKAKISHIGFYDYEYKDN ADSQLAMGKSKTSDLLLMG*LGERNGPLFFFFP RGRKLLLMIYIAKTKNT*KLIHTYVDIFCYVINV SCLHTFGLEKSAFVLCLL*V*NPNKRTC*I*SV LFVKTIASFTCIPSLFQIK*LFWVRI*MLGIYI LLLLNLGVKDFTTW*IMLDFNLLLAHFNSR*NMF FLVM*INVCCALHTCWIV*RLNSDMYILLFALV CNSCNFSALTSLKLQTSNFIIKLD*CFSRVIIF RRTI*NLKRLNLNSRFICYWMRRIST*FPLLPFA LPPCPIFCDIFSLLPVSQLT*ASHNLDRNLISQ TSRFRYIIQKSLNVSVIRNNLQITAP*TSQKFV SPTWFLSTLKGSSAVVITQRTQVKKQPPLYVAVS QTTEHGESHTGC*NIHLEATHICIHFSS*HK*C GFTNFPGGS*VQYYMLGKRKLICRQH**FPH*V KKIFILVFLIAFKQKRFLKVVLNI*KHHGIETFR THSL*VLTSMVL*SVKIR*NK*TKRNFR*LKGL YNRKREILVLKNSGN*NISV*YQALLQYCLKWL LF**MKMTKM