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Sequences

Sequence NM_181744

ACAGAATGGCGTTAAATCACACTGCCCTGCCTCAGGACGAGCGCCTGCCCCATTACCTTCGAGATGGGGATCCTTTTGCTTCCAAACTTTCTTGGGAAGC GGATTTAGTGGCTGGCTTTTACCTAACAATAATTGGGATTCTGTCCACATTTGGAAATGGATATGTCCTTTACATGTCTTCTAGACGAAAGAAGAAGCTG AGACCCGCTGAAATAATGACTATCAATTTAGCAGTCTGTGATCTGGGGATTTCAGTTGTAGGCAAGCCGTTCACCATCATCTCTTGCTTTTGTCACCGCT GGGTGTTTGGCTGGATCGGCTGCCGCTGGTATGGATGGGCTGGATTTTTCTTTGGCTGTGGAAGCCTTATCACCATGACTGCTGTCAGCCTGGATCGATA TTTGAAAATCTGCTATTTATCTTATGGGGTTTGGCTGAAAAGAAAGCACGCCTACATCTGCCTGGCAGCCATCTGGGCCTATGCTTCCTTCTGGACCACC ATGCCCTTGGTAGGTCTGGGGGACTACGTACCTGAGCCCTTCGGAACCTCGTGCACCCTGGACTGGTGGCTGGCCCAGGCCTCGGTAGGGGGCCAGGTTT TCATCCTGAACATCCTCTTCTTCTGCCTCTTGCTCCCAACGGCTGTGATCGTGTTCTCCTACGTAAAGATCATTGCCAAGGTTAAGTCCTCTTCCAAAGA AGTAGCTCATTTCGACAGTCGGATCCATAGCAGCCATGTGCTGGAAATGAAACTGACAAAGGTAGCGATGTTGATTTGTGCTGGATTCCTGATTGCCTGG ATTCCTTATGCAGTGGTGTCTGTGTGGTCAGCTTTTGGAAGGCCAGACTCCATTCCCATACAGCTCTCTGTGGTGCCAACCCTACTTGCAAAATCTGCAG CGATGTACAATCCCATCATTTACCAAGTTATTGATTACAAATTTGCCTGTTGCCAAACTGGTGGTTTGAAAGCAACCAAGAAGAAGTCTCTGGAAGGCTT CAGGCTGCACACCGTAACCACAGTCAGGAAGTCTTCTGCTGTGCTGGAAATTCATGAAGAGTGGGAATAACAAATGTTCTGGTTGTGAAGAGTGCATCTG AAGTGCTTACACGGCGTCTGGCATATGCAGAGAAATTAGCTTACAAATGTTATTTTTCTGACTTCTCGCCTCCACTCCACTTACCCTGTCAGGAAAAAAT AATTCACAAGGAATATCAAAACAATGATGCACCCTAGGAGTATCCAAGTATCTTAACTGAGTTATCTCATTCTGGTATAGTGGCAGAGTTATAACTAAAG AGTGCCAGAAACCCACGCTTTAAACATCCTGCAGTGCACACCTCGGTCTCGTCAGTAAGGACTTCACTTTCTTCTGAACTGGGGCTTGTGAAAGCTGGCC TGAAAAGCCTGATTCAAGGAGATCAGGCTGTGTCTCTGACTGGAGCAGCTACACTCCCCATCTGTAATTTGATTTGTTCTATTGCAGATGATGTACTGGG CAGAGGTGAGTGTGGATTGGTGAAAATCTGTTTTTATGACTGGCAAAGCAGTGCAGGGGGGTCTTTCACTGATAAGAAGCATCATCAGTAGGGTTTGTCC CTGATGCCTTTACAACAGCATCTGAGCACCTCTCAAGTTTTTCCAGGCCAGCTCCAGTTTCAGTGAGGAGAGTGTGGGCTTTCTATTCCCCAAATATTCT TACTACAGTTAATATGTAGGTTACTGCCCCAGCCCAACTGCAGGTTCCCAGATGTGAGTTCCATGTAGGCAGAAACTGTCCAGTTCTTGAAATTGAATTA CTTCCTTGTGTATGTGTTTTTTTCCTACTTAAAGCTCCTCGGGATGCTTCCTCTCAAAAGTCTTTGAAGAATAAGAGGTTAAGCTAAGACAACCTGAATC AATTTTTTTTTTTTTGTCAAATGCGATTGAAATTATCCCCATAATTCAATAAAATAGCTTTTTCCCTTCTTTCTTTTTACTTTGTTGGAAACTATGCAAC AGAAACAAAGTAAGAAGACTCTACCTTAATTTTAAAGGTAACTCTTACATAAAGAAGAAAGTCATTATGCCAGGCCAGGGGGAGAGTGGAAAGGGGAAAT TTAGAGAATAGAAACAAACTTAAGCATCTTGTAAATTTTGAGTGAATTGTAAACACATAATGAATGAATGAGAAGGGCCAGCCAGGAGTCTGTGAAATGG TCCAGTTGGGAAATGCCTAATGCATAAACACAAATCTTGGTGACAGGTAGGTTAGTTATCTGTGAACTTTCTAAAGATTAAATAAACAATAATAGGATTT TGTTAATGTGCCAAAGTGAGTTTAAACCATGAAAGACACGATGCAAATATGCAAGTACCTTTAATTGGGCATAATAAAAAGTAGTGAGGTATGGTTAAAA TAACATTTAGAACAAGAGAGAAGTTAGGGAGAATTTTTGTCTAAAAAGCCAAAAAGTGATAGTTGATTGGTGATTTTGTTGTTATCAGGAGAGAGAATTT TCTTAATGTAATAAGTTAGGTACTTTGGCAAGTGAAATGGGTTCTAGGCCAATTGCAAGTCCTTAGGATTCCCTGGCAGCTAGAAACCTTGGCACTCCCA AAAGACAGCTTCAGTTAAAATGACAGATGAACATGAGTCTTCAAGTCAAAACTACTGTTGTACCACGTCCATTGAATGTTTGGTGATTCAAGTCTCTGTT ATTCAAGAACTGATTCTGTTTTTCCTCCTGTCAAAACCTTGGTTGATTTTGACTGTAGTAGCACATCTGGCAGGAATATGACAGAAAAAAATTAAGTTAA AAATATAATTTCTATTCCCCTATTTTTTCTGTAAAAGGCTTTATGGGGAAGAAGGGAAGAAGGTTGACATGAGTAGAGATGATACTTGCCTCTGGATGAC CCAGTTGGGTTCTCCTTTGACTGCCATTCACCACAGTTGACCTCATTAGGCTCCGAAGTATGAGAAGAGCTTCATTGCCAAGTTAGTGAAAGAAGCAGAT GATTTACTTTTGCTCGAGTGGGTCTGTAGACCTCGGGAGGTTAGCCATTTCTCTTAGAGTTTGGTGTATGTATTAAGATACAGCATGTATGTAGGTATAT ATAATACATATATGTGTGTATACATATATATATATTTCTGGTTTGTTTAATATCTTTTAAAAAATTTTAATGGAATTTTTTGAACATGTACAAAAGAGAA AGAATCCTACGATGAACTCCCATGTATCCATCATCCAGCCTCAATAGTGATCAACCCATAGCATATTGTGGTTCATGTTGACACTCATCCACCTCTTTCC TTCCCCATCTCTCCCCATTATTTTGAGACGAATGAGATCCTGGGATTTCGTGAAAATATTATGAATATCTTATTTGTGAGAACAAGATTTCCCAAAGCAT GATCCCCAGAAACCTAGTCCTGCAAAACTACTGCAAAAATAAAGTGTTCTAATCTCCAAA

refseq_OPN5.F2 (forward primer)
refseq_OPN5.R2 (reverse primer)
Single exon skipping

Frame 0

TEWR*ITLPCLRTSACPITFEMGILLLPNFLGK RI*WLAFT*Q*LGFCPHLEMDMSFTCLLDERRS* DPLK**LSI*QSVIWGFQL*ASRSPSSLAFVTA GCLAGSAAAGMDGLDFSLAVEALSP*LLSAWID I*KSAIYLMGFG*KESTPTSAWQPSGPMLPSGPP CPW*VWGTTYLSPSEPRAPWTGGWPRPR*GARF SS*TSSSSASCSQRL*SCSPT*RSLPRLSPLPK K*LISTVGSIAAMCWK*N*QR*RC*FVLDS*LPG FLMQWCLCGQLLEGQTPFPYSSLWCQPYLQNLQ RCTIPSFTKLLITNLPVAKLVV*KQPRRSLWKA SGCTP*PQSGSLLLCWKFMKSGNNKCSGCEECI* SAYTASGICREISLQMLFF*LLASTPLTLSGKN NSQGISKQ*CTLGVSKYLN*VISFWYSGRVITK ECQKPTL*TSCSAHLGLVSKDFTFF*TGACESWP EKPDSRRSGCVSDWSSYTPHL*FDLFYCR*CTG QR*VWIGENLFL*LAKQCRGVFH**EASSVGFV PDAFTTASEHLSSFSRPAPVSVRRVWAFYSPNIL TTVNM*VTAPAQLQVPRCEFHVGRNCPVLEIEL LPCVCVFFLLKAPRDASSQKSLKNKRLS*DNLN QFFFFCQMRLKLSP*FNKIAFSLLSFYFVGNYAT ETK*EDSTLILKVTLT*RRKSLCQARGRVERGN LENRNKLKHLVNFE*IVNT**MNEKGQPGVCEM VQLGNA*CINTNLGDR*VSYL*TF*RLNKQ**DF VNVPK*V*TMKDTMQICKYL*LGIIKSSEVWLK *HLEQERS*GEFLSKKPKSDS*LVILLLSGERI FLM**VRYFGK*NGF*ANCKSLGFPGS*KPWHSQ KTASVKMTDEHESSSQNYCCTTSIECLVIQVSV IQELILFFLLSKPWLILTVVAHLAGI*QKKIKL KI*FLFPYFFCKRLYGEEGKKVDMSRDDTCLWMT QLGSPLTAIHHS*PH*APKYEKSFIAKLVKEAD DLLLLEWVCRPREVSHFS*SLVYVLRYSMYVGI YNTYMCVYIYIYFWFV*YLLKNFNGIF*TCTKEK ESYDELPCIHHPASIVINP*HIVVHVDTHPPLS FPISPHYFETNEILGFRENIMNILFVRTRFPKA *SPET*SCKTTAKIKCSNLQ

Frame 1

QNGVKSHCPASGRAPAPLPSRWGSFCFQTFLGS GFSGWLLPNNNWDSVHIWKWICPLHVF*TKEEA ETR*NNDYQFSSL*SGDFSCRQAVHHHLLLLSPL GVWLDRLPLVWMGWIFLWLWKPYHHDCCQPGSI FENLLFILWGLAEKKARLHLPGSHLGLCFLLDH HALGRSGGLRT*ALRNLVHPGLVAGPGLGRGPGF HPEHPLLLPLAPNGCDRVLLRKDHCQG*VLFQR SSSFRQSDP*QPCAGNETDKGSDVDLCWIPDCL DSLCSGVCVVSFWKARLHSHTALCGANPTCKICS DVQSHHLPSY*LQICLLPNWWFESNQEEVSGRL QAAHRNHSQEVFCCAGNS*RVGITNVLVVKSAS EVLTRRLAYAEKLAYKCYFSDFSPPLHLPCQEKI IHKEYQNNDAP*EYPSILTELSHSGIVAEL*LK SARNPRFKHPAVHTSVSSVRTSLSSELGLVKAG LKSLIQGDQAVSLTGAATLPICNLICSIADDVLG RGECGLVKICFYDWQSSAGGSFTDKKHHQ*GLS LMPLQQHLSTSQVFPGQLQFQ*GECGLSIPQIF LLQLICRLLPQPNCRFPDVSSM*AETVQFLKLNY FLVYVFFSYLKLLGMLPLKSL*RIRG*AKTT*I NFFFFVKCD*NYPHNSIK*LFPFFLFTLLETMQ QKQSKKTLP*F*R*LLHKEESHYARPGGEWKGEI *RIETNLSIL*ILSEL*THNE*MRRASQESVKW SSWEMPNA*TQILVTGRLVICELSKD*INNNRI LLMCQSEFKP*KTRCKYASTFNWA**KVVRYG*N NI*NKREVRENFCLKSQKVIVDW*FCCYQEREF S*CNKLGTLASEMGSRPIASP*DSLAARNLGTP KRQLQLK*QMNMSLQVKTTVVPRPLNVW*FKSLL FKN*FCFSSCQNLG*F*L**HIWQEYDRKKLS* KYNFYSPIFSVKGFMGKKGRRLT*VEMILASG* PSWVLL*LPFTTVDLIRLRSMRRASLPS**KKQM IYFCSSGSVDLGRLAISLRVWCMY*DTACM*VY IIHICVYTYIYISGLFNIF*KILMEFFEHVQKR KNPTMNSHVSIIQPQ**STHSILWFMLTLIHLFP SPSLPIILRRMRSWDFVKIL*ISYL*EQDFPKH DPQKPSPAKLLQK*SVLISK

Frame 2

RMALNHTALPQDERLPHYLRDGDPFASKLSWEA DLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKL RPAEIMTINLAVCDLGISVVGKPFTIISCFCHR WVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRY LKICYLSYGVWLKRKHAYICLAAIWAYASFWTT MPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQV FILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKE VAHFDSRIHSSHVLEMKLTKVAMLICAGFLIAW IPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSA AMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGF RLHTVTTVRKSSAVLEIHEEWE*QMFWL*RVHL KCLHGVWHMQRN*LTNVIFLTSRLHSTYPVRKK *FTRNIKTMMHPRSIQVS*LSYLILV*WQSYN*R VPETHALNILQCTPRSRQ*GLHFLLNWGL*KLA *KA*FKEIRLCL*LEQLHSPSVI*FVLLQMMYW AEVSVDW*KSVFMTGKAVQGGLSLIRSIISRVCP *CLYNSI*APLKFFQASSSFSEESVGFLFPKYS YYS*YVGYCPSPTAGSQM*VPCRQKLSSS*N*I TSLCMCFFPT*SSSGCFLSKVFEE*EVKLRQPES IFFFLSNAIEIIPIIQ*NSFFPSFFLLCWKLCN RNKVRRLYLNFKGNSYIKKKVIMPGQGESGKGK FRE*KQT*ASCKF*VNCKHIMNE*EGPARSL*NG PVGKCLMHKHKSW*QVG*LSVNFLKIK*TIIGF C*CAKVSLNHERHDANMQVPLIGHNKK**GMVK ITFRTREKLGRIFV*KAKK**LIGDFVVIRRENF LNVIS*VLWQVKWVLGQLQVLRIPWQLETLALP KDSFS*NDR*T*VFKSKLLLYHVH*MFGDSSLC YSRTDSVFPPVKTLVDFDCSSTSGRNMTEKN*VK NIISIPLFFL*KALWGRREEG*HE*R*YLPLDD PVGFSFDCHSPQLTSLGSEV*EELHCQVSERSR *FTFARVGL*TSGG*PFLLEFGVCIKIQHVCRYI *YIYVCIHIYIFLVCLISFKKF*WNFLNMYKRE RILR*TPMYPSSSLNSDQPIAYCGSC*HSSTSF LPHLSPLF*DE*DPGIS*KYYEYLICENKISQSM IPRNLVLQNYCKNKVF*SP

Sequence NM_001030051

ATATGTAATCATGACTTAGTGACATATCACAAGCATAGGAAGCTTCTGGTTCAGTGGTCCTCAAATGCAACTCACAAAATATCATCTGGGGAAGTTCTGA ATTAAGTCGTTGAGAGTGTTACCTGGGCATCAGGATATTTAAAATGAGAATCTACAGTTGTAGGCAAGCCGTTCACCATCATCTCTTGCTTTTGTCACCG CTGGGTGTTTGGCTGGATCGGCTGCCGCTGGTATGGATGGGCTGGATTTTTCTTTGGCTGTGGAAGCCTTATCACCATGACTGCTGTCAGCCTGGATCGA TATTTGAAAATCTGCTATTTATCTTATGTTCTGACTTCTGGAGCAACACAGAACCAATCTACTAATCTACTCCCTCCTGTACTTGACAGCCTTTCACCAT ACTGGAATGGGTTTGGCTGAAAAGAAAGCACGCCTACATCTGCCTGGCAGCCATCTGGGCCTATGCTTCCTTCTGGACCACCATGCCCTTGGTAGGTCTG GGGGACTACGTACCTGAGCCCTTCGGAACCTCGTGCACCCTGGACTGGTGGCTGGCCCAGGCCTCGGTAGGGGGCCAGGTTTTCATCCTGAACATCCTCT TCTTCTGCCTCTTGCTCCCAACGGCTGTGATCGTGTTCTCCTACGTAAAGATCATTGCCAAGGTTAAGTCCTCTTCCAAAGAAGTAGCTCATTTCGACAG TCGGATCCATAGCAGCCATGTGCTGGAAATGAAACTGACAAAGGTAGCGATGTTGATTTGTGCTGGATTCCTGATTGCCTGGATTCCTTATGCAGTGGTG TCTGTGTGGTCAGCTTTTGGAAGGCCAGACTCCATTCCCATACAGCTCTCTGTGGTGCCAACCCTACTTGCAAAATCTGCAGCGATGTACAATCCCATCA TTTACCAAGTTATTGATTACAAATTTGCCTGTTGCCAAACTGGTGGTTTGAAAGCAACCAAGAAGAAGTCTCTGGAAGGCTTCAGGCTGCACACCGTAAC CACAGTCAGGAAGTCTTCTGCTGTGCTGGAAATTCATGAAGAGTGGGAATAACAAATGTTCTGGTTGTGAAGAGTGCATCTGAAGTGCTTACACGGCGTC TGGCATATGCAGAGAAATTAGCTTACAAATGTTATTTTTCTGACTTCTCGCCTCCACTCCACTTACCCTGTCAGGAAAAAATAATTCACAAGGAATATCA AAACAATGATGCACCCTAGGAGTATCCAAGTATCTTAACTGAGTTATCTCATTCTGGTATAGTGGCAGAGTTATAACTAAAGAGTGCCAGAAACCCACGC TTTAAACATCCTGCAGTGCACACCTCGGTCTCGTCAGTAAGGACTTCACTTTCTTCTGAACTGGGGCTTGTGAAAGCTGGCCTGAAAAGCCTGATTCAAG GAGATCAGGCTGTGTCTCTGACTGGAGCAGCTACACTCCCCATCTGTAATTTGATTTGTTCTATTGCAGATGATGTACTGGGCAGAGGTGAGTGTGGATT GGTGAAAATCTGTTTTTATGACTGGCAAAGCAGTGCAGGGGGGTCTTTCACTGATAAGAAGCATCATCAGTAGGGTTTGTCCCTGATGCCTTTACAACAG CATCTGAGCACCTCTCAAGTTTTTCCAGGCCAGCTCCAGTTTCAGTGAGGAGAGTGTGGGCTTTCTATTCCCCAAATATTCTTACTACAGTTAATATGTA GGTTACTGCCCCAGCCCAACTGCAGGTTCCCAGATGTGAGTTCCATGTAGGCAGAAACTGTCCAGTTCTTGAAATTGAATTACTTCCTTGTGTATGTGTT TTTTTCCTACTTAAAGCTCCTCGGGATGCTTCCTCTCAAAAGTCTTTGAAGAATAAGAGGTTAAGCTAAGACAACCTGAATCAATTTTTTTTTTTTTGTC AAATGCGATTGAAATTATCCCCATAATTCAATAAAATAGCTTTTTCCCTTCTTTCTTTTTACTTTGTTGGAAACTATGCAACAGAAACAAAGTAAGAAGA CTCTACCTTAATTTTAAAGGTAACTCTTACATAAAGAAGAAAGTCATTATGCCAGGCCAGGGGGAGAGTGGAAAGGGGAAATTTAGAGAATAGAAACAAA CTTAAGCATCTTGTAAATTTTGAGTGAATTGTAAACACATAATGAATGAATGAGAAGGGCCAGCCAGGAGTCTGTGAAATGGTCCAGTTGGGAAATGCCT AATGCATAAACACAAATCTTGGTGACAGGTAGGTTAGTTATCTGTGAACTTTCTAAAGATTAAATAAACAATAATAGGATTTTGTTAATGTGCCAAAGTG AGTTTAAACCATGAAAGACACGATGCAAATATGCAAGTACCTTTAATTGGGCATAATAAAAAGTAGTGAGGTATGGTTAAAATAACATTTAGAACAAGAG AGAAGTTAGGGAGAATTTTTGTCTAAAAAGCCAAAAAGTGATAGTTGATTGGTGATTTTGTTGTTATCAGGAGAGAGAATTTTCTTAATGTAATAAGTTA GGTACTTTGGCAAGTGAAATGGGTTCTAGGCCAATTGCAAGTCCTTAGGATTCCCTGGCAGCTAGAAACCTTGGCACTCCCAAAAGACAGCTTCAGTTAA AATGACAGATGAACATGAGTCTTCAAGTCAAAACTACTGTTGTACCACGTCCATTGAATGTTTGGTGATTCAAGTCTCTGTTATTCAAGAACTGATTCTG TTTTTCCTCCTGTCAAAACCTTGGTTGATTTTGACTGTAGTAGCACATCTGGCAGGAATATGACAGAAAAAAATTAAGTTAAAAATATAATTTCTATTCC CCTATTTTTTCTGTAAAAGGCTTTATGGGGAAGAAGGGAAGAAGGTTGACATGAGTAGAGATGATACTTGCCTCTGGATGACCCAGTTGGGTTCTCCTTT GACTGCCATTCACCACAGTTGACCTCATTAGGCTCCGAAGTATGAGAAGAGCTTCATTGCCAAGTTAGTGAAAGAAGCAGATGATTTACTTTTGCTCGAG TGGGTCTGTAGACCTCGGGAGGTTAGCCATTTCTCTTAGAGTTTGGTGTATGTATTAAGATACAGCATGTATGTAGGTATATATAATACATATATGTGTG TATACATATATATATATTTCTGGTTTGTTTAATATCTTTTAAAAAATTTTAATGGAATTTTTTGAACATGTACAAAAGAGAAAGAATCCTACGATGAACT CCCATGTATCCATCATCCAGCCTCAATAGTGATCAACCCATAGCATATTGTGGTTCATGTTGACACTCATCCACCTCTTTCCTTCCCCATCTCTCCCCAT TATTTTGAGACGAATGAGATCCTGGGATTTCGTGAAAATATTATGAATATCTTATTTGTGAGAACAAGATTTCCCAAAGCATGATCCCCAGAAACCTAGT CCTGCAAAACTACTGCAAAAATAAAGTGTTCTAATCTCCAAA

refseq_OPN5.F2 (forward primer)
refseq_OPN5.R2 (reverse primer)
Single exon skipping

Frame 0

ICNHDLVTYHKHRKLLVQWSSNATHKISSGEVL N*VVESVTWASGYLK*ESTVVGKPFTIISCFCHR WVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDR YLKICYLSYVLTSGATQNQSTNLLPPVLDSLSP YWNGFG*KESTPTSAWQPSGPMLPSGPPCPW*VW GTTYLSPSEPRAPWTGGWPRPR*GARFSS*TSS SSASCSQRL*SCSPT*RSLPRLSPLPKK*LIST VGSIAAMCWK*N*QR*RC*FVLDS*LPGFLMQWC LCGQLLEGQTPFPYSSLWCQPYLQNLQRCTIPS FTKLLITNLPVAKLVV*KQPRRSLWKASGCTP* PQSGSLLLCWKFMKSGNNKCSGCEECI*SAYTAS GICREISLQMLFF*LLASTPLTLSGKNNSQGIS KQ*CTLGVSKYLN*VISFWYSGRVITKECQKPT L*TSCSAHLGLVSKDFTFF*TGACESWPEKPDSR RSGCVSDWSSYTPHL*FDLFYCR*CTGQR*VWI GENLFL*LAKQCRGVFH**EASSVGFVPDAFTT ASEHLSSFSRPAPVSVRRVWAFYSPNILTTVNM* VTAPAQLQVPRCEFHVGRNCPVLEIELLPCVCV FFLLKAPRDASSQKSLKNKRLS*DNLNQFFFFC QMRLKLSP*FNKIAFSLLSFYFVGNYATETK*ED STLILKVTLT*RRKSLCQARGRVERGNLENRNK LKHLVNFE*IVNT**MNEKGQPGVCEMVQLGNA *CINTNLGDR*VSYL*TF*RLNKQ**DFVNVPK* V*TMKDTMQICKYL*LGIIKSSEVWLK*HLEQE RS*GEFLSKKPKSDS*LVILLLSGERIFLM**V RYFGK*NGF*ANCKSLGFPGS*KPWHSQKTASVK MTDEHESSSQNYCCTTSIECLVIQVSVIQELIL FFLLSKPWLILTVVAHLAGI*QKKIKLKI*FLF PYFFCKRLYGEEGKKVDMSRDDTCLWMTQLGSPL TAIHHS*PH*APKYEKSFIAKLVKEADDLLLLE WVCRPREVSHFS*SLVYVLRYSMYVGIYNTYMC VYIYIYFWFV*YLLKNFNGIF*TCTKEKESYDEL PCIHHPASIVINP*HIVVHVDTHPPLSFPISPH YFETNEILGFRENIMNILFVRTRFPKA*SPET* SCKTTAKIKCSNLQ

Frame 1

YVIMT**HITSIGSFWFSGPQMQLTKYHLGKF* IKSLRVLPGHQDI*NENLQL*ASRSPSSLAFVT AGCLAGSAAAGMDGLDFSLAVEALSP*LLSAWID I*KSAIYLMF*LLEQHRTNLLIYSLLYLTAFHH TGMGLAEKKARLHLPGSHLGLCFLLDHHALGRS GGLRT*ALRNLVHPGLVAGPGLGRGPGFHPEHPL LLPLAPNGCDRVLLRKDHCQG*VLFQRSSSFRQ SDP*QPCAGNETDKGSDVDLCWIPDCLDSLCSG VCVVSFWKARLHSHTALCGANPTCKICSDVQSHH LPSY*LQICLLPNWWFESNQEEVSGRLQAAHRN HSQEVFCCAGNS*RVGITNVLVVKSASEVLTRR LAYAEKLAYKCYFSDFSPPLHLPCQEKIIHKEYQ NNDAP*EYPSILTELSHSGIVAEL*LKSARNPR FKHPAVHTSVSSVRTSLSSELGLVKAGLKSLIQ GDQAVSLTGAATLPICNLICSIADDVLGRGECGL VKICFYDWQSSAGGSFTDKKHHQ*GLSLMPLQQ HLSTSQVFPGQLQFQ*GECGLSIPQIFLLQLIC RLLPQPNCRFPDVSSM*AETVQFLKLNYFLVYVF FSYLKLLGMLPLKSL*RIRG*AKTT*INFFFFV KCD*NYPHNSIK*LFPFFLFTLLETMQQKQSKK TLP*F*R*LLHKEESHYARPGGEWKGEI*RIETN LSIL*ILSEL*THNE*MRRASQESVKWSSWEMP NA*TQILVTGRLVICELSKD*INNNRILLMCQS EFKP*KTRCKYASTFNWA**KVVRYG*NNI*NKR EVRENFCLKSQKVIVDW*FCCYQEREFS*CNKL GTLASEMGSRPIASP*DSLAARNLGTPKRQLQL K*QMNMSLQVKTTVVPRPLNVW*FKSLLFKN*FC FSSCQNLG*F*L**HIWQEYDRKKLS*KYNFYS PIFSVKGFMGKKGRRLT*VEMILASG*PSWVLL *LPFTTVDLIRLRSMRRASLPS**KKQMIYFCSS GSVDLGRLAISLRVWCMY*DTACM*VYIIHICV YTYIYISGLFNIF*KILMEFFEHVQKRKNPTMN SHVSIIQPQ**STHSILWFMLTLIHLFPSPSLPI ILRRMRSWDFVKIL*ISYL*EQDFPKHDPQKPS PAKLLQK*SVLISK

Frame 2

M*S*LSDISQA*EASGSVVLKCNSQNIIWGSSE LSR*ECYLGIRIFKMRIYSCRQAVHHHLLLLSP LGVWLDRLPLVWMGWIFLWLWKPYHHDCCQPGS IFENLLFILCSDFWSNTEPIY*STPSCT*QPFTI LEWVWLKRKHAYICLAAIWAYASFWTTMPLVGL GDYVPEPFGTSCTLDWWLAQASVGGQVFILNIL FFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDS RIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVV SVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPI IYQVIDYKFACCQTGGLKATKKKSLEGFRLHTVT TVRKSSAVLEIHEEWE*QMFWL*RVHLKCLHGV WHMQRN*LTNVIFLTSRLHSTYPVRKK*FTRNI KTMMHPRSIQVS*LSYLILV*WQSYN*RVPETHA LNILQCTPRSRQ*GLHFLLNWGL*KLA*KA*FK EIRLCL*LEQLHSPSVI*FVLLQMMYWAEVSVD W*KSVFMTGKAVQGGLSLIRSIISRVCP*CLYNS I*APLKFFQASSSFSEESVGFLFPKYSYYS*YV GYCPSPTAGSQM*VPCRQKLSSS*N*ITSLCMC FFPT*SSSGCFLSKVFEE*EVKLRQPESIFFFLS NAIEIIPIIQ*NSFFPSFFLLCWKLCNRNKVRR LYLNFKGNSYIKKKVIMPGQGESGKGKFRE*KQ T*ASCKF*VNCKHIMNE*EGPARSL*NGPVGKCL MHKHKSW*QVG*LSVNFLKIK*TIIGFC*CAKV SLNHERHDANMQVPLIGHNKK**GMVKITFRTR EKLGRIFV*KAKK**LIGDFVVIRRENFLNVIS* VLWQVKWVLGQLQVLRIPWQLETLALPKDSFS* NDR*T*VFKSKLLLYHVH*MFGDSSLCYSRTDS VFPPVKTLVDFDCSSTSGRNMTEKN*VKNIISIP LFFL*KALWGRREEG*HE*R*YLPLDDPVGFSF DCHSPQLTSLGSEV*EELHCQVSERSR*FTFAR VGL*TSGG*PFLLEFGVCIKIQHVCRYI*YIYVC IHIYIFLVCLISFKKF*WNFLNMYKRERILR*T PMYPSSSLNSDQPIAYCGSC*HSSTSFLPHLSP LF*DE*DPGIS*KYYEYLICENKISQSMIPRNLV LQNYCKNKVF*SP