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Sequences

Sequence XM_371717

ACCAGCAGGACTGATGTGCACACAGAAGGAATGAAGTATGGATGTGAAAGAACGCAGGCCTTACTGCTCCCTGACCAAGAGCAGACGAGAGAAGGAACGG CGCTACACAAATTCCTCCGCAGACAATGAGGAGTGCCGGGTACCCACACAGAAGTCCTACAGTTCCAGCGAGACATTGAAAGCTTTTGATCATGATTCCT CGCGGCTGCTTTACGGCAACAGAGTGAAGGATTTGGTTCACAGAGAAGCAGACGAGTTCACTAGACAAGGACAGAATTTTACCCTAAGGCAGTTAGGAGT TTGTGAACCAGCAACTCGAAGAGGACTGGCATTTTGTGCGGAAATGGGGCTCCCTCACAGAGGTTACTCTATCAGTGCAGGGTCAGATGCTGATACTGAA AATGAAGCAGTGATGTCCCCAGAGCATGCCATGAGACTTTGGGGCAGGGGGGTCAAATCAGGCCGCAGCTCCTGCCTGTCAAGTCGGTCCAACTCAGCCC TCACCCTGACAGATACGGAGCACGAAAACAAGTCCGACAGTGAGAATGAGCAACCTGCAAGCAATCAAGGCCAGTCTACCCTGCAGCCCTTGCCGCCTTC CCATAAGCAGCACTCTGCACAGCATCATCCATCCATCACTTCTCTCAACAGAAACTCCCTGACCAATAGAAGGAACCAGAGTCCGGCCCCGCCGGCTGCT TTGCCCGCCGAGCTGCAAACCACACCCGAGTCCGTCCAGCTGCAGGACAGCTGGGTCCTTGGCAGTAATGTACCACTGGAAAGCAGGCATTTCCTATTCA AAACAGGAACAGGTACAACGCCACTGTTCAGTACTGCAACCCCAGGATACACAATGGCATCTGGCTCTGTTTATTCACCACCTACTCGGCCACTACCTAG AAACACCCTATCAAGAAGTGCTTTTAAATTCAAGAAGTCTTCAAAGTACTGTAGCTGGAAATGCACTGCACTGTGTGCCGTAGGGGTCTCGGTGCTCCTG GCAATACTCCTGTCTTATTTTATAGCAATGCATCTCTTTGGCCTCAACTGGCAGCTACAGCAGACTGAAAATGACACATTTGAGAATGGAAAAGTGAATT CTGATACCATGCCAACAAACACTGTGTCATTACCTTCTGGAGACAATGGAAAATTAGGTGGATTTACGCAAGAAAATAACACCATAGATTCCGGAGAACT TGATATTGGCCGAAGAGCAATTCAAGAGATTCCTCCCGGGATCTTCTGGAGATCACAGCTCTTCATTGATCAGCCACAGTTTCTTAAATTCAATATCTCT CTTCAGAAGGATGCATTGATTGGAGTATATGGCCGGAAAGGCTTACCGCCTTCCCATACTCAGTATGACTTCGTGGAGCTCCTGGATGGCAGCAGGCTGA TTGCCAGAGAGCAGCGGAGCCTGCTTGAGACGGAGAGAGCCGGGCGGCAGGCGAGATCCGTCAGCCTTCATGAGGCCGGCTTTATCCAGTACTTGGATTC TGGAATCTGGCATCTGGCTTTTTATAATGATGGGAAAAATGCAGAGCAGGTGTCTTTTAATACCATTGTTATAGAGTCTGTGGTGGAATGTCCCCGAAAT TGCCATGGAAATGGAGAATGCGTTTCTGGAACTTGCCATTGTTTTCCAGGATTTCTGGGTCCGGATTGTTCAAGAGCCGCCTGTCCAGTGTTATGTAGTG GCAACGGGCAGTACTCCAAGGGCCGCTGCCTGTGTTTCAGCGGCTGGAAGGGCACCGAGTGTGATGTGCCGACTACCCAGTGTATTGACCCACAGTGTGG GGGTCGTGGGATTTGTATCATGGGCTCTTGTGCTTGCAACTCAGGATACAAAGGAGAAAGTTGTGAAGAAGCTGACTGTATAGACCCTGGGTGTTCTAAT CATGGTGTGTGTATCCACGGGGAATGTCACTGCAGTCCAGGATGGGGAGGTAGCAATTGTGAAATACTGAAGACCATGTGTCCAGACCAGTGCTCCGGCC ACGGAACGTATCTTCAAGAAAGTGGCTCCTGCACGTGTGACCCTAACTGGACTGGCCCAGACTGCTCAAACGAAATATGTTCTGTGGACTGTGGCTCACA CGGCGTTTGCATGGGGGGGACGTGTCGCTGTGAAGAAGGCTGGACGGGCCCAGCCTGTAATCAGAGAGCCTGCCACCCCCGCTGTGCCGAGCACGGGACC TGCAAGGATGGCAAGTGTGAATGCAGCCAGGGCTGGAATGGAGAGCACTGCACTATCGAGGGTTGTCCTGGTCTGTGCAACAGCAATGGAAGATGTACCC TGGACCAAAATGGCTGGCATTGTGTGTGCCAGCCTGGATGGAGAGGAGCAGGCTGTGACGTAGCCATGGAGACTCTTTGCACAGATAGCAAGGACAATGA AGGAGATGGACTCATTGACTGCATGGATCCCGATTGCTGCCTACAGAGTTCCTGCCAGAATCAGCCCTATTGTCGGGGACTGCCGGATCCTCAGGACATC ATTAGCCAAAGCCTTCAATCGCCTTCTCAGCAAGCTGCCAAATCCTTTTATGATCGAATCAGTTTCCTTATAGGATCTGATAGCACCCATGTTATACCTG GAGAAAGTCCTTTCAATAAGAGCCTTGCATCTGTCATCAGAGGCCAAGTACTGACTGCTGATGGAACTCCACTTATTGGAGTAAATGTCTCGTTTTTCCA TTACCCAGAATATGGATATACTATTACCCGCCAGGACGGAATGTTTGACTTGGTGGCAAATGGTGGGGCCTCTCTAACTTTGGTATTTGAACGATCCCCA TTCCTCACTCAGTATCATACTGTGTGGATTCCATGGAATGTCTTTTATGTGATGGATACCCTAGTCATGAAGAAAGAAGAGAATGATATTCCCAGCTGTG ATCTGAGTGGATTCGTGAGGCCAAATCCCATCATTGTGTCATCACCTTTATCCACCTTTTTCAGATCTTCTCCTGAAGACAGTCCCATCATTCCCGAAAC ACAGGTACTCCACGAGGAAACTACAATTCCAGGAACAGATTTGAAACTCTCCTACTTGAGTTCCAGAGCTGCAGGGTATAAGTCAGTTCTCAAGATCACC ATGACCCAGTCTATTATTCCATTTAATTTAATGAAGGTTCATCTTATGGTAGCTGTAGTAGGAAGACTCTTCCAAAAGTGGTTTCCTGCCTCACCAAACT TGGCCTATACTTTCATATGGGATAAAACAGATGCATATAATCAGAAAGTCTATGGTCTATCTGAAGCTGTTGTGTCAGTTGGATATGAGTATGAGTCGTG TTTGGACCTGACTCTGTGGGAAAAGAGGACTGCCATTCTGCAGGGCTATGAATTGGATGCGTCCAACATGGGTGGCTGGACATTAGATAAACATCACGTG CTGGATGTACAGAACGGTATACTGTACAAGGGAAACGGGGAAAACCAGTTCATCTCCCAGCAGCCTCCAGTCGTGAGTAGCATCATGGGCAATGGGCGAA GGCGCAGCATTTCCTGCCCCAGTTGCAATGGTCAAGCTGATGGTAACAAGTTACTGGCCCCAGTGGCGCTAGCTTGTGGGATCGATGGCAGTCTGTACGT AGGCGATTTCAACTATGTGCGGCGGATATTCCCTTCTGGAAATGTAACAAGTGTCTTAGAACTAAGCAGCAACCCAGCTCATAGATACTACCTTGCAACG GATCCAGTCACGGGAGATCTGTACGTTTCTGACACAAACACCCGCAGAATTTATCGCCCAAAGTCACTTACGGGGGCAAAAGACTTGACTAAAAATGCAG AAGTCGTCGCAGGGACAGGGGAGCAATGCCTTCCGTTTGACGAGGCGAGATGTGGGGATGGAGGGAAGGCCGTGGAAGCCACACTCATGAGTCCCAAAGG AATGGCAGTTGATAAGAATGGATTAATCTACTTTGTTGATGGAACCATGATTAGGAAAGTTGACCAAAATGGAATCATATCAACTCTTCTGGGCTCTAAC GATTTGACTTCAGCCAGACCTTTAACTTGTGACACCAGCATGCACATCAGCCAGGTACGTCTGGAATGGCCCACTGACCTAGCCATTAACCCTATGGATA ACTCCATTTATGTCCTGGATAATAATGTAGTTTTACAGATCACTGAAAATCGTCAAGTTCGCATTGCTGCTGGACGGCCCATGCACTGTCAGGTTCCCGG AGTGGAATATCCTGTGGGGAAGCACGCGGTGCAGACAACACTGGAATCAGCCACTGCCATTGCTGTGTCCTACAGTGGGGTCCTGTACATTACTGAAACT GATGAGAAGAAAATTAACCGGATAAGGCAGGTCACAACAGATGGAGAAATCTCCTTAGTGGCCGGAATACCTTCAGAGTGTGACTGCAAAAATGATGCCA ACTGTGACTGTTACCAGAGTGGAGATGGCTACGCCAAGGATGCCAAACTCAGTGCCCCATCCTCCCTGGCTGCTTCTCCAGATGGTACACTGTATATTGC AGATCTAGGGAATATCCGGATCCGGGCTGTGTCAAAGAATAAGCCTTTACTTAACTCTATGAACTTCTATGAAGTTGCGTCTCCAACTGATCAAGAACTC TACATCTTTGACATCAATGGTACTCACCAATATACTGTAAGTTTAGTCACTGGTGATTACCTTTACAATTTTAGCTACAGCAATGACAATGATATTACTG CTGTGACAGACAGCAATGGCAACACCCTTAGAATTAGACGGGACCCAAATCGCATGCCAGTTCGAGTGGTGTCTCCTGATAACCAAGTGATATGGTTGAC AATAGGAACAAATGGATGTTTGAAAAGCATGACTGCTCAAGGACTGGAATTAGTTTTGTTTACTTACCATGGCAATAGTGGCCTTTTAGCCACTAAAAGT GATGAAACTGGATGGACAACGTTTTTTGACTATGACAGTGAAGGTCGTCTGACAAATGTTACGTTTCCAACTGGAGTGGTCACAAACCTGCATGGGGACA TGGACAAGGCTATCACAGTGGACATTGAGTCATCTAGCCGAGAAGAAGATGTCAGCATCACTTCAAATCTGTCCTCGATCGATTCTTTCTACACCATGGT TCAAGATCAGTTAAGAAACAGCTACCAGATTGGTTATGACGGCTCCCTCAGAATTATCTACGCCAGTGGCCTGGACTCACACTACCAAACAGAGCCGCAC GTTCTGGCTGGCACCGCTAATCCGACGGTTGCCAAAAGAAACATGACTTTGCCTGGCGAGAACGGTCAAAACTTGGTGGAATGGAGATTCCGAAAAGAGC AAGCCCAAGGGAAAGTCAATGTCTTTGGCCGCAAGCTCAGGGTTAATGGCAGAAACCTCCTTTCAGTTGACTTTGATCGAACAACAAAGACAGAAAAGAT CTATGACGACCACCGTAAATTTCTACTGAGGATCGCCTACGACACGTCTGGGCACCCGACTCTCTGGCTGCCAAGCAGCAAGCTGATGGCCGTCAATGTC ACCTATTCATCCACAGGTCAAATTGCCAGCATCCAGCGAGGCACCACTAGCGAGAAAGTAGATTATGACGGACAGGGGAGGATCGTGTCTCGGGTCTTTG CTGATGGTAAAACATGGAGTTACACATATTTAGAAAAGTCCATGGTTCTTCTGCTTCATAGCCAGCGGCAGTACATCTTCGAATACGATATGTGGGACCG CCTGTCTGCCATCACCATGCCCAGTGTGGCTCGCCACACCATGCAGACCATCCGATCCATTGGCTACTACCGCAACATATACAACCCCCCGGAAAGCAAC GCCTCCATCATCACGGACTACAACGAGGAAGGGCTGCTTCTACAAACAGCTTTCTTGGGTACAAGTCGGAGGGTCTTATTCAAATACAGAAGGCAGACTA GGCTCTCAGAAATTTTATATGATAGCACAAGAGTCAGTTTTACCTATGATGAAACAGCAGGAGTCCTAAAGACAGTAAACCTCCAGAGTGATGGTTTTAT TTGCACCATTAGATACAGGCAAATTGGTCCCCTGATTGACAGGCAGATTTTCCGCTTTAGTGAAGATGGGATGGTAAATGCAAGATTTGACTATAGCTAT GACAACAGCTTTCGAGTGACCAGCATGCAGGGTGTGATCAATGAAACGCCACTGCCTATTGATCTGTATCAGTTTGATGACATTTCTGGCAAAGTTGAGC AGTTTGGAAAGTTTGGAGTTATATATTATGATATTAACCAGATCATTTCTACAGCTGTAATGACCTATACGAAGCACTTTGATGCTCATGGCCGTATCAA GGAGATTCAATATGAGATATTCAGGTCGCTCATGTACTGGATTACAATTCAGTATGATAACATGGGTCGGGTAACCAAGAGAGAGATTAAAATAGGGCCC TTTGCCAACACCACCAAATATGCTTATGAATATGATGTTGATGGACAGCTCCAAACAGTTTACCTCAATGAAAAGATAATGTGGCGGTACAACTACGATC TGAATGGAAACCTCCATTTACTGAACCCAAGTAACAGTGCGCGTCTGACACCCCTTCGCTATGACCTGCGAGACAGAATCACTCGACTGGGTGATGTTCA ATATCGGTTGGATGAAGATGGTTTCCTACGTCAAAGGGGCACGGAAATCTTTGAATATAGCTCCAAGGGGCTTCTAACTCGAGTTTACAGTAAAGGCAGT GGCTGGACAGTGATCTACCGTTATGACGGCCTGGGAAGGCGTGTTTCTAGCAAAACCAGTCTAGGACAGCACCTGCAGTTTTTTTATGCTGACTTAACTT ATCCCACTAGGATTACTCATGTCTACAACCATTCGAGTTCAGAAATTACCTCCCTGTATTATGATCTCCAAGGACATCTTTTTGCCATGGAAATCAGCAG TGGGGATGAATTCTATATTGCATCGGATAACACAGGGACACCACTGGCTGTGTTCAGTAGCAATGGGCTTATGCTGAAACAGATTCAGTACACTGCATAT GGGGAAATCTATTTTGACTCTAATATTGACTTTCAACTGGTAATTGGATTTCATGGTGGCCTGTATGACCCACTCACCAAATTAATCCACTTTGGAGAAA GAGATTATGACATTTTGGCAGGACGGTGGACAACACCTGACATAGAAATCTGGAAAAGAATTGGGAAGGACCCAGCTCCTTTTAACTTGTACATGTTTAG GAATAACAACCCTGCAAGCAAAATCCATGACGTGAAAGATTACATCACAGATGTTAACAGCTGGCTGGTGACATTTGGTTTCCATCTGCACAATGCTATT CCTGGATTCCCTGTTCCCAAATTTGATTTAACAGAACCTTCTTACGAACTTGTGAAGAGTCAGCAGTGGGATGATATACCGCCCATCTTCGGAGTCCAGC AGCAAGTGGCGCGGCAGGCCAAGGCCTTCCTGTCGCTGGGGAAGATGGCCGAGGTGCAGGTGAGCCGGCGCCGGGCCGGCGGCGCGCAGTCCTGGCTGTG GTTCGCCACGGTCAAGTCGCTGATCGGCAAGGGCGTCATGCTGGCCGTCAGCCAGGGCCGCGTGCAGACCAACGTGCTCAACATCGCCAACGAGGACTGC ATCAAGGTGGCGGCCGTGCTCAACAACGCCTTCTACCTGGAGAACCTGCACTTCACCATCGAGGGCAAGGACACGCACTACTTCATCAAGACCACCACGC CCGAGAGCGACCTGGGCACGCTGCGGTTGACCAGCGGCCGCAAGGCGCTGGAGAACGGCATCAACGTGACGGTGTCGCAGTCCACCACGGTGGTGAACGG CAGGACGCGCAGGTTCGCGGACGTGGAGATGCAGTTCGGCGCGCTGGCGCTGCACGTGCGCTACGGCATGACCCTGGACGAGGAGAAGGCGCGCATCCTG GAGCAGGCGCGGCAGCGCGCGCTCGCCCGGGCCTGGGCGCGCGAGCAGCAGCGCGTGCGCGACGGCGAGGAGGGCGCGCGCCTCTGGACGGAGGGCGAGA AGCGGCAGCTGCTGAGCGCCGGCAAGGTGCAGGGCTACGACGGGTACTACGTACTCTCGGTGGAGCAGTACCCCGAGCTGGCCGACAGCGCCAACAACAT CCAGTTCCTGCGGCAGAGCGAGATCGGCAGGAGGTAACGCCCGGGCCGCGCCCGCCGAGCCGCTCACGCCCTGCCCACATTGTCCTGTGGCACAACCCGA GTGGGACTCTCCAACGCCCAAGAGCCTTCCTCCCGGGGGAATGAGACTGCTGTTACGACCCACACCCACACCGCGAAAACAAGGACCGCTTTTTTCCGAA TGACCTTAAAGGTGATCGGCTTTAACGAATATGTTTACATATGCATAGCGCTGCACTCAGTCGGACTGAACGTAGCCAGAGGAAAAAAAAATCATCAAGG ACAAAGGCCTCGACCTGTTGCGCTGGGCCGTCTGTTCCTTCTAGGCACTGTATTTAACTAACTTTAAAAAAGAAAAAAAAATGTGTACAGTGTTTCCAAA TAGTCCCGAATTGTCGACCTTTGCTTACAAGAAGTAGTCTGTCTGCATAGGATGTGATAGCTATCTCTGTTCATTTTACAATGTGGGGCAAAGTTACTGT TTCTAGACAACCCAACTGCTTTCCCTGTGCAGCTTTGTAGAAGGACATTGGCACAGTGACTTCTGCGGCGGGGATTTATTAATGGATTTTACAATGCTAA CGTGGTTTCCCTTCGGGGAAAAAACTGGCAACTAGAATCCTTGTCACTGATAAGCAAAGGAAATCCTGATTTTTTTGTAAATTATGTGAGACAAGTTGTT TATGGATTTTTATATGAATTACAATTTACTGTACATCAAATCTTAGTCTCAGAGGAGTTAATTTATGTAAAGTGTTTAAAAATTTATACTTAAAAATAAA ATGATAAAAACGTGAACTGTGTGATTTTTTTAAAAGGATTGCACCTTTTGTTATCTGTTATAGCTGTACAGTATGAATTATTATATTGTAGAGATATAAC AACTTATGCCTATAATGTCCAGAAGTGTTAATATTTTTGTATTAGGTTGAAAAAATGTGCAAGCTTCTATCACTAGATGGATAGGACCGTGCAATTCTAG GTGGGTGGCGAATCAGAGAGCTCCTTTCTCTTCCCTCTCTCACGCATCAGGCCAGTGTCCTCAGCATTGTCAACTGAGAGGCACAGTAGACAACTAGGGC TGGTGGAATGTAAGGGAAGAAGATTGAAAAAACGGGAGGAAGGGTTCTCTGGCCCTCTCTCAACCTTGCAAGTCAATGGGGAGTTGTTGATATAATTAAC CCCGAGGTTTTTACTGTTACTGTTCCAAAGCTCTGTCTCTTGATGGAGGAGAGACCACATCAGATGCTGGGGAAATAGGAGGAGGAAAGGTTCTGATGTA GTCGTGATCCTAAACACGTGTCTTAAGATCTAGGAAAGACAGCAGAAACCGAGCAGTGGTGGGTGAGCCAGATGGAGCCGGTCAGGGTTACTCTAAGCCC ACATGACCAAACCATCTTGGGGGGCTGGTTTGAATGACAGCCTCTGCTCTGTCTCGGGGAAGCCGGGGGTGGCAGATCCAGCTGGAAGTGAACTGACAGC CGCGCCCTCCTGCACACATGCATGCACGCGTGTGGGAACGAGCCCAGCCGCCATCTGCACTTCCGTGTCGGCTCAGCTCTGACAAATCTCTTTCCTGAGC ACTAAATTCAGCCACGAAAATATTTTTAGAAGATATTTCTCAGTTCATCGAGCTATAGTACACACTGTTTTCCTCTATGTATAATGGTGATAAAATATAG CAAGTGAACATGTCGTAAATATAAAGGTTCAAGTGATGTATTGAAAATAATTTTCTAACTGCTTTGTATGTATCACATACTCTAAATTGCACAGTAGGCG TGTTTATTAAACAGATGATTGGCTGGGAAAGTTTCAAAATAGCTACTGAATTTACAGTATCAGTGCTATTACTGTCTTTGTGTATTTGGTAGAGCATACC GAAGTAATTAATCTTCTAATGAATGCTGATGATATTTTATTAGAATGAAAGCACAGATTAGCATTAATATTTTTTATTCTGGAAATCCTTTGGCAAGTAT TATGAAGCCCAAATTTAGAAAACTATGAGATTTCAAACCACATAAACATGATTCTGTTTTCCATTTTATTTTTTAACTGTTAGGTATTTGCAGTTCTGTT CCGTGGAACTTCTGCAGGCCTGTATTTAGCATGCTGTAAGTACTTTTGGGTGAAATAGGCTCTGAGTCTAAATTCTCAGACATGTTTCTGATGTATTACC ATGAAAAGCTTGTGCCACATGACAGAAGTGAGATCATAGTCTTAACCTCTTCTTGACGTGGACTGGTCTTCACTCGGGCACCGATAAATAACAGATTTGG AGTATCTCCTGGTGCTTATTTTAGATGATGAAGTCAAATCAACCCAATTAGTGTCCTGTTAGTAGGTATAATGAGCCTATTTCTTTCTAAAAAGACTTGT GATCTGGACATGCTTTTACAAGAAATAGTGACCTTGGGGAATATGTAAACAAAAGACCTTTTTCTAAGAGTTGGGAGGGGGTGGGGGACTGTATAATGAA AAGAATTAGCTTACAAAAAAGAAATTGATATTCAAAGTATTTTAGGCAAAGCCAGTCAAAATGCTTTCATGATATTTTGAGATGTAAATTTTGTCTGATT TGTATTGTTCTTTTCATTTGCCTTCTTAACTTTATATGTGACCTGAATTTTCCATAACTTGATGACTATAGATTGCACCTAGGCATTCCAATAAAAGCCA ACCCAATGTG

refseq_ODZ3.F3 (forward primer)
refseq_ODZ3.R3 (reverse primer)
Single exon skipping

Frame 0

TSRTDVHTEGMKYGCERTQALLLPDQEQTREGT ALHKFLRRQ*GVPGTHTEVLQFQRDIESF*S*FL AAALRQQSEGFGSQRSRRVH*TRTEFYPKAVRS L*TSNSKRTGILCGNGAPSQRLLYQCRVRC*Y* K*SSDVPRACHETLGQGGQIRPQLLPVKSVQLSP HPDRYGARKQVRQ*E*ATCKQSRPVYPAALAAF P*AALCTASSIHHFSQQKLPDQ*KEPESGPAGC FARRAANHTRVRPAAGQLGPWQ*CTTGKQAFPIQ NRNRYNATVQYCNPRIHNGIWLCLFTTYSATT* KHPIKKCF*IQEVFKVL*LEMHCTVCRRGLGAP GNTPVLFYSNASLWPQLAATAD*K*HI*EWKSEF *YHANKHCVITFWRQWKIRWIYARK*HHRFRRT *YWPKSNSRDSSRDLLEITALH*SATVS*IQYL SSEGCIDWSIWPERLTAFPYSV*LRGAPGWQQAD CQRAAEPA*DGESRAAGEIRQPS*GRLYPVLGF WNLASGFL**WEKCRAGVF*YHCYRVCGGMSPK LPWKWRMRFWNLPLFSRISGSGLFKSRLSSVM*W QRAVLQGPLPVFQRLEGHRV*CADYPVY*PTVW GSWDLYHGLLCLQLRIQRRKL*RS*LYRPWVF* SWCVYPRGMSLQSRMGR*QL*NTEDHVSRPVLRP RNVSSRKWLLHV*P*LDWPRLLKRNMFCGLWLT RRLHGGDVSL*RRLDGPSL*SESLPPPLCRARD LQGWQV*MQPGLEWRALHYRGLSWSVQQQWKMYP GPKWLALCVPAWMERSRL*RSHGDSLHR*QGQ* RRWTH*LHGSRLLPTEFLPESALLSGTAGSSGH H*PKPSIAFSASCQILL*SNQFPYRI**HPCYTW RKSFQ*EPCICHQRPSTDC*WNSTYWSKCLVFP LPRIWIYYYPPGRNV*LGGKWWGLSNFGI*TIP IPHSVSYCVDSMECLLCDGYPSHEERRE*YSQL* SEWIREAKSHHCVITFIHLFQIFS*RQSHHSRN TGTPRGNYNSRNRFETLLLEFQSCRV*VSSQDH HDPVYYSI*FNEGSSYGSCSRKTLPKVVSCLTKL GLYFHMG*NRCI*SESLWSI*SCCVSWI*V*VV FGPDSVGKEDCHSAGL*IGCVQHGWLDIR*TSR AGCTERYTVQGKRGKPVHLPAASSRE*HHGQWAK AQHFLPQLQWSS*W*QVTGPSGASLWDRWQSVR RRFQLCAADIPFWKCNKCLRTKQQPSS*ILPCN GSSHGRSVRF*HKHPQNLSPKVTYGGKRLD*KCR SRRRDRGAMPSV*RGEMWGWREGRGSHTHESQR NGS**EWINLLC*WNHD*ES*PKWNHINSSGL* RFDFSQTFNL*HQHAHQPGTSGMAH*PSH*PYG* LHLCPG**CSFTDH*KSSSSHCCWTAHALSGSR SGISCGEARGADNTGISHCHCCVLQWGPVHY*N **EEN*PDKAGHNRWRNLLSGRNTFRV*LQK*CQ L*LLPEWRWLRQGCQTQCPILPGCFSRWYTVYC RSREYPDPGCVKE*AFT*LYELL*SCVSN*SRT LHL*HQWYSPIYCKFSHW*LPLQF*LQQ*Q*YYC CDRQQWQHP*N*TGPKSHASSSGVS**PSDMVD NRNKWMFEKHDCSRTGISFVYLPWQ*WPFSH*K **NWMDNVF*L*Q*RSSDKCYVSNWSGHKPAWGH GQGYHSGH*VI*PRRRCQHHFKSVLDRFFLHHG SRSVKKQLPDWL*RLPQNYLRQWPGLTLPNRAA RSGWHR*SDGCQKKHDFAWRERSKLGGMEIPKRA SPRESQCLWPQAQG*WQKPPFS*L*SNNKDRKD L*RPP*ISTEDRLRHVWAPDSLAAKQQADGRQC HLFIHRSNCQHPARHH*RESRL*RTGEDRVSGLC *W*NMELHIFRKVHGSSAS*PAAVHLRIRYVGP PVCHHHAQCGSPHHADHPIHWLLPQHIQPPGKQ RLHHHGLQRGRAASTNSFLGYKSEGLIQIQKAD* ALRNFI**HKSQFYL**NSRSPKDSKPPE*WFY LHH*IQANWSPD*QADFPL**RWDGKCKI*L*L *QQLSSDQHAGCDQ*NATAY*SVSV**HFWQS*A VWKVWSYIL*Y*PDHFYSCNDLYEAL*CSWPYQ GDSI*DIQVAHVLDYNSV**HGSGNQERD*NRA LCQHHQICL*I*C*WTAPNSLPQ*KDNVAVQLRS EWKPPFTEPK*QCASDTPSL*PARQNHSTG*CS ISVG*RWFPTSKGHGNL*I*LQGASNSSLQ*RQ WLDSDLPL*RPGKACF*QNQSRTAPAVFLC*LNL SH*DYSCLQPFEFRNYLPVL*SPRTSFCHGNQQ WG*ILYCIG*HRDTTGCVQ*QWAYAETDSVHCI WGNLF*L*Y*LSTGNWISWWPV*PTHQINPLWRK RL*HFGRTVDNT*HRNLEKNWEGPSSF*LVHV* E*QPCKQNP*RERLHHRC*QLAGDIWFPSAQCY SWIPCSQI*FNRTFLRTCEESAVG*YTAHLRSPA ASGAAGQGLPVAGEDGRGAGEPAPGRRRAVLAV VRHGQVADRQGRHAGRQPGPRADQRAQHRQRGL HQGGGRAQQRLLPGEPALHHRGQGHALLHQDHHA RERPGHAAVDQRPQGAGERHQRDGVAVHHGGER QDAQVRGRGDAVRRAGAARALRHDPGRGEGAHP GAGAAARARPGLGARAAARARRRGGRAPLDGGRE AAAAERRQGAGLRRVLRTLGGAVPRAGRQRQQH PVPAAERDRQEVTPGPRPPSRSRPAHIVLWHNP SGTLQRPRAFLPGE*DCCYDPHPHRENKDRFFPN DLKGDRL*RICLHMHSAALSRTERSQRKKKSSR TKASTCCAGPSVPSRHCI*LTLKKKKKCVQCFQ IVPNCRPLLTRSSLSA*DVIAISVHFTMWGKVTV SRQPNCFPCAAL*KDIGTVTSAAGIY*WILQC* RGFPSGKKLATRILVTDKQRKS*FFCKLCETSC LWIFI*ITIYCTSNLSLRGVNLCKVFKNLYLKIK **KRELCDFFKRIAPFVICYSCTV*IIIL*RYN NLCL*CPEVLIFLY*VEKMCKLLSLDG*DRAIL GGWRIRELLSLPSLTHQASVLSIVN*EAQ*TTRA GGM*GKKIEKTGGRVLWPSLNLASQWGVVDIIN PEVFTVTVPKLCLLMEERPHQMLGK*EEERF*C SRDPKHVS*DLGKTAETEQWWVSQMEPVRVTLSP HDQTILGGWFE*QPLLCLGEAGGGRSSWK*TDS RALLHTCMHACGNEPSRHLHFRVGSALTNLFPE H*IQPRKYF*KIFLSSSSYSTHCFPLCIMVIKYS K*TCRKYKGSSDVLKIIF*LLCMYHIL*IAQ*A CLLNR*LAGKVSK*LLNLQYQCYYCLCVFGRAY RSN*SSNEC**YFIRMKAQISINIFYSGNPLASI MKPKFRKL*DFKPHKHDSVFHFIF*LLGICSSV PWNFCRPVFSML*VLLGEIGSESKFSDMFLMYY HEKLVPHDRSEIIVLTSS*RGLVFTRAPINNRFG VSPGAYFR**SQINPISVLLVGIMSLFLSKKTC DLDMLLQEIVTLGNM*TKDLFLRVGRGWGTV** KELAYKKEIDIQSILGKASQNAFMIF*DVNFV*F VLFFSFAFLTLYVT*IFHNLMTIDCT*AFQ*KP TQC

Frame 1

PAGLMCTQKE*SMDVKERRPYCSLTKSRREKER RYTNSSADNEECRVPTQKSYSSSETLKAFDHDS SRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGV CEPATRRGLAFCAEMGLPHRGYSISAGSDADTE NEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSA LTLTDTEHENKSDSENEQPASNQGQSTLQPLPPS HKQHSAQHHPSITSLNRNSLTNRRNQSPAPPAA LPAELQTTPESVQLQDSWVLGSNVPLESRHFLF KTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPR NTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLL AILLSYFIAMHLFGLNWQLQQTENDTFENGKVN SDTMPTNTVSLPSGDNGKLGGFTQENNTIDSGEL DIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNIS LQKDALIGVYGRKGLPPSHTQYDFVELLDGSRL IAREQRSLLETERAGRQARSVSLHEAGFIQYLDS GIWHLAFYNDGKNAEQVSFNTIVIESVVECPRN CHGNGECVSGTCHCFPGFLGPDCSRAACPVLCS GNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCG GRGICIMGSCACNSGYKGESCEEADCIDPGCSN HGVCIHGECHCSPGWGGSNCEILKTMCPDQCSG HGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSH GVCMGGTCRCEEGWTGPACNQRACHPRCAEHGT CKDGKCECSQGWNGEHCTIEGCPGLCNSNGRCT LDQNGWHCVCQPGWRGAGCDVAMETLCTDSKDNE GDGLIDCMDPDCCLQSSCQNQPYCRGLPDPQDI ISQSLQSPSQQAAKSFYDRISFLIGSDSTHVIP GESPFNKSLASVIRGQVLTADGTPLIGVNVSFFH YPEYGYTITRQDGMFDLVANGGASLTLVFERSP FLTQYHTVWIPWNVFYVMDTLVMKKEENDIPSC DLSGFVRPNPIIVSSPLSTFFRSSPEDSPIIPET QVLHEETTIPGTDLKLSYLSSRAAGYKSVLKIT MTQSIIPFNLMKVHLMVAVVGRLFQKWFPASPN LAYTFIWDKTDAYNQKVYGLSEAVVSVGYEYESC LDLTLWEKRTAILQGYELDASNMGGWTLDKHHV LDVQNGILYKGNGENQFISQQPPVVSSIMGNGR RRSISCPSCNGQADGNKLLAPVALACGIDGSLYV GDFNYVRRIFPSGNVTSVLELSSNPAHRYYLAT DPVTGDLYVSDTNTRRIYRPKSLTGAKDLTKNA EVVAGTGEQCLPFDEARCGDGGKAVEATLMSPKG MAVDKNGLIYFVDGTMIRKVDQNGIISTLLGSN DLTSARPLTCDTSMHISQVRLEWPTDLAINPMD NSIYVLDNNVVLQITENRQVRIAAGRPMHCQVPG VEYPVGKHAVQTTLESATAIAVSYSGVLYITET DEKKINRIRQVTTDGEISLVAGIPSECDCKNDA NCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIA DLGNIRIRAVSKNKPLLNSMNFYEVASPTDQEL YIFDINGTHQYTVSLVTGDYLYNFSYSNDNDIT AVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLT IGTNGCLKSMTAQGLELVLFTYHGNSGLLATKS DETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGD MDKAITVDIESSSREEDVSITSNLSSIDSFYTMV QDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPH VLAGTANPTVAKRNMTLPGENGQNLVEWRFRKE QAQGKVNVFGRKLRVNGRNLLSVDFDRTTKTEKI YDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNV TYSSTGQIASIQRGTTSEKVDYDGQGRIVSRVF ADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDR LSAITMPSVARHTMQTIRSIGYYRNIYNPPESN ASIITDYNEEGLLLQTAFLGTSRRVLFKYRRQT RLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFI CTIRYRQIGPLIDRQIFRFSEDGMVNARFDYSY DNSFRVTSMQGVINETPLPIDLYQFDDISGKVE QFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK EIQYEIFRSLMYWITIQYDNMGRVTKREIKIGP FANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYD LNGNLHLLNPSNSARLTPLRYDLRDRITRLGDVQ YRLDEDGFLRQRGTEIFEYSSKGLLTRVYSKGS GWTVIYRYDGLGRRVSSKTSLGQHLQFFYADLT YPTRITHVYNHSSSEITSLYYDLQGHLFAMEISS GDEFYIASDNTGTPLAVFSSNGLMLKQIQYTAY GEIYFDSNIDFQLVIGFHGGLYDPLTKLIHFGE RDYDILAGRWTTPDIEIWKRIGKDPAPFNLYMFR NNNPASKIHDVKDYITDVNSWLVTFGFHLHNAI PGFPVPKFDLTEPSYELVKSQQWDDIPPIFGVQ QQVARQAKAFLSLGKMAEVQVSRRRAGGAQSWLW FATVKSLIGKGVMLAVSQGRVQTNVLNIANEDC IKVAAVLNNAFYLENLHFTIEGKDTHYFIKTTT PESDLGTLRLTSGRKALENGINVTVSQSTTVVNG RTRRFADVEMQFGALALHVRYGMTLDEEKARIL EQARQRALARAWAREQQRVRDGEEGARLWTEGE KRQLLSAGKVQGYDGYYVLSVEQYPELADSANNI QFLRQSEIGRR*RPGRARRAAHALPTLSCGTTR VGLSNAQEPSSRGNETAVTTHTHTAKTRTAFFR MTLKVIGFNEYVYICIALHSVGLNVARGKKNHQG QRPRPVALGRLFLLGTVFN*L*KRKKNVYSVSK *SRIVDLCLQEVVCLHRM**LSLFILQCGAKLL FLDNPTAFPVQLCRRTLAQ*LLRRGFINGFYNAN VVSLRGKNWQLESLSLISKGNPDFFVNYVRQVV YGFLYELQFTVHQILVSEELIYVKCLKIYT*K* NDKNVNCVIFLKGLHLLLSVIAVQYELLYCRDIT TYAYNVQKC*YFCIRLKKCASFYH*MDRTVQF* VGGESESSFLFPLSRIRPVSSALSTERHSRQLG LVECKGRRLKKREEGFSGPLSTLQVNGELLI*LT PRFLLLLFQSSVS*WRRDHIRCWGNRRRKGSDV VVILNTCLKI*ERQQKPSSGG*ARWSRSGLL*A HMTKPSWGAGLNDSLCSVSGKPGVADPAGSELTA APSCTHACTRVGTSPAAICTSVSAQL*QISFLS TKFSHENIFRRYFSVHRAIVHTVFLYV*W**NI ASEHVVNIKVQVMY*K*FSNCFVCITYSKLHSRR VY*TDDWLGKFQNSY*IYSISAITVFVYLVEHT EVINLLMNADDILLE*KHRLALIFFILEILWQV L*SPNLENYEISNHINMILFSILFFNC*VFAVLF RGTSAGLYLACCKYFWVK*ALSLNSQTCF*CIT MKSLCHMTEVRS*S*PLLDVDWSSLGHR*ITDL EYLLVLILDDEVKSTQLVSC**V**AYFFLKRLV IWTCFYKK**PWGICKQKTFF*ELGGGGGLYNE KN*LTKKKLIFKVF*AKPVKMLS*YFEM*ILSD LYCSFHLPS*LYM*PEFSIT**L*IAPRHSNKSQ PNV

Frame 2

QQD*CAHRRNEVWM*KNAGLTAP*PRADERRNG ATQIPPQTMRSAGYPHRSPTVPARH*KLLIMIP RGCFTATE*RIWFTEKQTSSLDKDRILP*GS*E FVNQQLEEDWHFVRKWGSLTEVTLSVQGQMLILK MKQ*CPQSMP*DFGAGGSNQAAAPACQVGPTQP SP*QIRSTKTSPTVRMSNLQAIKASLPCSPCRL PISSTLHSIIHPSLLSTETP*PIEGTRVRPRRLL CPPSCKPHPSPSSCRTAGSLAVMYHWKAGISYS KQEQVQRHCSVLQPQDTQWHLALFIHHLLGHYL ETPYQEVLLNSRSLQSTVAGNALHCVP*GSRCSW QYSCLIL*QCISLASTGSYSRLKMTHLRMEK*I LIPCQQTLCHYLLETMEN*VDLRKKITP*IPEN LILAEEQFKRFLPGSSGDHSSSLISHSFLNSISL FRRMH*LEYMAGKAYRLPILSMTSWSSWMAAG* LPESSGACLRRREPGGRRDPSAFMRPALSSTWI LESGIWLFIMMGKMQSRCLLIPLL*SLWWNVPEI AMEMENAFLELAIVFQDFWVRIVQEPPVQCYVV ATGSTPRAAACVSAAGRAPSVMCRLPSVLTHSV GVVGFVSWALVLATQDTKEKVVKKLTV*TLGVLI MVCVSTGNVTAVQDGEVAIVKY*RPCVQTSAPA TERIFKKVAPARVTLTGLAQTAQTKYVLWTVAH TAFAWGGRVAVKKAGRAQPVIREPATPAVPSTGP ARMASVNAARAGMESTALSRVVLVCATAMEDVP WTKMAGIVCASLDGEEQAVT*PWRLFAQIARTM KEMDSLTAWIPIAAYRVPARISPIVGDCRILRTS LAKAFNRLLSKLPNPFMIESVSL*DLIAPMLYL EKVLSIRALHLSSEAKY*LLMELHLLE*MSRFS ITQNMDILLPARTECLTWWQMVGPL*LWYLNDPH SSLSIILCGFHGMSFM*WIP*S*RKKRMIFPAV I*VDS*GQIPSLCHHLYPPFSDLLLKTVPSFPK HRYSTRKLQFQEQI*NSPT*VPELQGISQFSRSP *PSLLFHLI**RFILW*L**EDSSKSGFLPHQT WPILSYGIKQMHIIRKSMVYLKLLCQLDMSMSR VWT*LCGKRGLPFCRAMNWMRPTWVAGH*INITC WMYRTVYCTRETGKTSSSPSSLQS*VASWAMGE GAAFPAPVAMVKLMVTSYWPQWR*LVGSMAVCT *AISTMCGGYSLLEM*QVS*N*AATQLIDTTLQR IQSREICTFLTQTPAEFIAQSHLRGQKT*LKMQ KSSQGQGSNAFRLTRRDVGMEGRPWKPHS*VPK EWQLIRMD*STLLMEP*LGKLTKMESYQLFWALT I*LQPDL*LVTPACTSARYVWNGPLT*PLTLWI TPFMSWIIM*FYRSLKIVKFALLLDGPCTVRFP EWNILWGSTRCRQHWNQPLPLLCPTVGSCTLLKL MRRKLTG*GRSQQMEKSP*WPEYLQSVTAKMMP TVTVTRVEMATPRMPNSVPHPPWLLLQMVHCIL QI*GISGSGLCQRISLYLTL*TSMKLRLQLIKNS TSLTSMVLTNIL*V*SLVITFTILATAMTMILL L*QTAMATPLELDGTQIACQFEWCLLITK*YG* Q*EQMDV*KA*LLKDWN*FCLLTMAIVAF*PLKV MKLDGQRFLTMTVKVV*QMLRFQLEWSQTCMGT WTRLSQWTLSHLAEKKMSASLQICPRSILSTPW FKIS*ETATRLVMTAPSELSTPVAWTHTTKQSRT FWLAPLIRRLPKET*LCLARTVKTWWNGDSEKS KPKGKSMSLAASSGLMAETSFQLTLIEQQRQKR SMTTTVNFY*GSPTTRLGTRLSGCQAAS*WPSMS PIHPQVKLPASSEAPLARK*IMTDRGGSCLGSL LMVKHGVTHI*KSPWFFCFIASGSTSSNTICGT ACLPSPCPVWLATPCRPSDPLATTATYTTPRKAT PPSSRTTTRKGCFYKQLSWVQVGGSYSNTEGRL GSQKFYMIAQESVLPMMKQQES*RQ*TSRVMVL FAPLDTGKLVP*LTGRFSALVKMGW*MQDLTIAM TTAFE*PACRV*SMKRHCLLICISLMTFLAKLS SLESLELYIMILTRSFLQL**PIRSTLMLMAVS RRFNMRYSGRSCTGLQFSMITWVG*PRERLK*GP LPTPPNMLMNMMLMDSSKQFTSMKR*CGGTTTI *METSIY*TQVTVRV*HPFAMTCETESLDWVMF NIGWMKMVSYVKGARKSLNIAPRGF*LEFTVKAV AGQ*STVMTAWEGVFLAKPV*DSTCSFFMLT*L IPLGLLMSTTIRVQKLPPCIMISKDIFLPWKSA VGMNSILHRITQGHHWLCSVAMGLC*NRFSTLHM GKSILTLILTFNW*LDFMVACMTHSPN*STLEK EIMTFWQDGGQHLT*KSGKELGRTQLLLTCTCL GITTLQAKSMT*KITSQMLTAGW*HLVSICTMLF LDSLFPNLI*QNLLTNL*RVSSGMIYRPSSESS SKWRGRPRPSCRWGRWPRCR*AGAGPAARSPGC GSPRSSR*SARASCWPSARAACRPTCSTSPTRTA SRWRPCSTTPSTWRTCTSPSRARTRTTSSRPPR PRATWARCG*PAAARRWRTAST*RCRSPPRW*T AGRAGSRTWRCSSARWRCTCATA*PWTRRRRASW SRRGSARSPGPGRASSSACATARRARASGRRAR SGSC*APARCRATTGTTYSRWSSTPSWPTAPTT SSSCGRARSAGGNARAAPAEPLTPCPHCPVAQPE WDSPTPKSLPPGGMRLLLRPTPTPRKQGPLFSE *P*R*SALTNMFTYA*RCTQSD*T*PEEKKIIK DKGLDLLRWAVCSF*ALYLTNFKKEKKMCTVFPN SPELSTFAYKK*SVCIGCDSYLCSFYNVGQSYC F*TTQLLSLCSFVEGHWHSDFCGGDLLMDFTML TWFPFGEKTGN*NPCH**AKEILIFL*IM*DKLF MDFYMNYNLLYIKS*SQRS*FM*SV*KFILKNK MIKT*TV*FF*KDCTFCYLL*LYSMNYYIVEI* QLMPIMSRSVNIFVLG*KNVQASITRWIGPCNSR WVANQRAPFSSLSHASGQCPQHCQLRGTVDN*G WWNVREED*KNGRKGSLALSQPCKSMGSC*YN* PRGFYCYCSKALSLDGGETTSDAGEIGGGKVLM* S*S*TRVLRSRKDSRNRAVVGEPDGAGQGYSKP T*PNHLGGLV*MTASALSRGSRGWQIQLEVN*Q PRPPAHMHARVWERAQPPSALPCRLSSDKSLS*A LNSATKIFLEDISQFIEL*YTLFSSMYNGDKI* QVNMS*I*RFK*CIENNFLTALYVSHTLNCTVG VFIKQMIGWESFKIATEFTVSVLLLSLCIW*SIP K*LIF**MLMIFY*NESTD*H*YFLFWKSFGKY YEAQI*KTMRFQTT*T*FCFPFYFLTVRYLQFC SVELLQACI*HAVSTFG*NRL*V*ILRHVSDVLP *KACAT*QK*DHSLNLFLTWTGLHSGTDK*QIW SISWCLF*MMKSNQPN*CPVSRYNEPISF*KDL *SGHAFTRNSDLGEYVNKRPFSKSWEGVGDCIMK RISLQKRN*YSKYFRQSQSKCFHDILRCKFCLI CIVLFICLLNFICDLNFP*LDDYRLHLGIPIKA NPM

Sequence XM_931600

ACCAGCAGGACTGATGTGCACACAGAAGGAATGAAGTATGGATGTGAAAGAACGCAGGCCTTACTGCTCCCTGACCAAGAGCAGACGAGAGAAGGAACGG CGCTACACAAATTCCTCCGCAGACAATGAGGAGTGCCGGGTACCCACACAGAAGTCCTACAGTTCCAGCGAGACATTGAAAGCTTTTGATCATGATTCCT CGCGGCTGCTTTACGGCAACAGAGTGAAGGATTTGGTTCACAGAGAAGCAGACGAGTTCACTAGACAAGGACAGAATTTTACCCTAAGGCAGTTAGGAGT TTGTGAACCAGCAACTCGAAGAGGACTGGCATTTTGTGCGGAAATGGGGCTCCCTCACAGAGGTTACTCTATCAGTGCAGGGTCAGATGCTGATACTGAA AATGAAGCAGTGATGTCCCCAGAGCATGCCATGAGACTTTGGGGCAGGGGGGTCAAATCAGGCCGCAGCTCCTGCCTGTCAAGTCGGTCCAACTCAGCCC TCACCCTGACAGATACGGAGCACGAAAACAAGTCCGACAGTGAGAATGAGCAACCTGCAAGCAATCAAGGCCAGTCTACCCTGCAGCCCTTGCCGCCTTC CCATAAGCAGCACTCTGCACAGCATCATCCATCCATCACTTCTCTCAACAGAAACTCCCTGACCAATAGAAGGAACCAGAGTCCGGCCCCGCCGGCTGCT TTGCCCGCCGAGCTGCAAACCACACCCGAGTCCGTCCAGCTGCAGGACAGCTGGGTCCTTGGCAGTAATGTACCACTGGAAAGCAGGCATTTCCTATTCA AAACAGGAACAGGTACAACGCCACTGTTCAGTACTGCAACCCCAGGATACACAATGGCATCTGGCTCTGTTTATTCACCACCTACTCGGCCACTACCTAG AAACACCCTATCAAGAAGTGCTTTTAAATTCAAGAAGTCTTCAAAGTACTGTAGCTGGAAATGCACTGCACTGTGTGCCGTAGGGGTCTCGGTGCTCCTG GCAATACTCCTGTCTTATTTTATAGCAATGCATCTCTTTGGCCTCAACTGGCAGCTACAGCAGACTGAAAATGACACATTTGAGAATGGAAAAGTGAATT CTGATACCATGCCAACAAACACTGTGTCATTACCTTCTGGAGACAATGGAAAATTAGGTGGATTTACGCAAGAAAATAACACCATAGATTCCGGAGAACT TGATATTGGCCGAAGAGCAATTCAAGAGATTCCTCCCGGGATCTTCTGGAGATCACAGCTCTTCATTGATCAGCCACAGTTTCTTAAATTCAATATCTCT CTTCAGAAGGATGCATTGATTGGAGTATATGGCCGGAAAGGCTTACCGCCTTCCCATACTCAGTATGACTTCGTGGAGCTCCTGGATGGCAGCAGGCTGA TTGCCAGAGAGCAGCGGAGCCTGCTTGAGACGGAGAGAGCCGGGCGGCAGGCGAGATCCGTCAGCCTTCATGAGGCCGGCTTTATCCAGTACTTGGATTC TGGAATCTGGCATCTGGCTTTTTATAATGATGGGAAAAATGCAGAGCAGGTGTCTTTTAATACCATTGTTATAGAGTCTGTGGTGGAATGTCCCCGAAAT TGCCATGGAAATGGAGAATGCGTTTCTGGAACTTGCCATTGTTTTCCAGGATTTCTGGGTCCGGATTGTTCAAGAGCCGCCTGTCCAGTGTTATGTAGTG GCAACGGGCAGTACTCCAAGGGCCGCTGCCTGTGTTTCAGCGGCTGGAAGGGCACCGAGTGTGATGTGCCGACTACCCAGTGTATTGACCCACAGTGTGG GGGTCGTGGGATTTGTATCATGGGCTCTTGTGCTTGCAACTCAGGATACAAAGGAGAAAGTTGTGAAGAAGCTGACTGTATAGACCCTGGGTGTTCTAAT CATGGTGTGTGTATCCACGGGGAATGTCACTGCAGTCCAGGATGGGGAGGTAGCAATTGTGAAATACTGAAGACCATGTGTCCAGACCAGTGCTCCGGCC ACGGAACGTATCTTCAAGAAAGTGGCTCCTGCACGTGTGACCCTAACTGGACTGGCCCAGACTGCTCAAACGAAATATGTTCTGTGGACTGTGGCTCACA CGGCGTTTGCATGGGGGGGACGTGTCGCTGTGAAGAAGGCTGGACGGGCCCAGCCTGTAATCAGAGAGCCTGCCACCCCCGCTGTGCCGAGCACGGGACC TGCAAGGATGGCAAGTGTGAATGCAGCCAGGGCTGGAATGGAGAGCACTGCACTATCGCTCACTATTTGGATAAGATAGTTAAAGAGGGTTGTCCTGGTC TGTGCAACAGCAATGGAAGATGTACCCTGGACCAAAATGGCTGGCATTGTGTGTGCCAGCCTGGATGGAGAGGAGCAGGCTGTGACGTAGCCATGGAGAC TCTTTGCACAGATAGCAAGGACAATGAAGGAGATGGACTCATTGACTGCATGGATCCCGATTGCTGCCTACAGAGTTCCTGCCAGAATCAGCCCTATTGT CGGGGACTGCCGGATCCTCAGGACATCATTAGCCAAAGCCTTCAATCGCCTTCTCAGCAAGCTGCCAAATCCTTTTATGATCGAATCAGTTTCCTTATAG GATCTGATAGCACCCATGTTATACCTGGAGAAAGTCCTTTCAATAAGAGCCTTGCATCTGTCATCAGAGGCCAAGTACTGACTGCTGATGGAACTCCACT TATTGGAGTAAATGTCTCGTTTTTCCATTACCCAGAATATGGATATACTATTACCCGCCAGGACGGAATGTTTGACTTGGTGGCAAATGGTGGGGCCTCT CTAACTTTGGTATTTGAACGATCCCCATTCCTCACTCAGTATCATACTGTGTGGATTCCATGGAATGTCTTTTATGTGATGGATACCCTAGTCATGAAGA AAGAAGAGAATGATATTCCCAGCTGTGATCTGAGTGGATTCGTGAGGCCAAATCCCATCATTGTGTCATCACCTTTATCCACCTTTTTCAGATCTTCTCC TGAAGACAGTCCCATCATTCCCGAAACACAGGTACTCCACGAGGAAACTACAATTCCAGGAACAGATTTGAAACTCTCCTACTTGAGTTCCAGAGCTGCA GGGTATAAGTCAGTTCTCAAGATCACCATGACCCAGTCTATTATTCCATTTAATTTAATGAAGGTTCATCTTATGGTAGCTGTAGTAGGAAGACTCTTCC AAAAGTGGTTTCCTGCCTCACCAAACTTGGCCTATACTTTCATATGGGATAAAACAGATGCATATAATCAGAAAGTCTATGGTCTATCTGAAGCTGTTGT GTCAGTTGGATATGAGTATGAGTCGTGTTTGGACCTGACTCTGTGGGAAAAGAGGACTGCCATTCTGCAGGGCTATGAATTGGATGCGTCCAACATGGGT GGCTGGACATTAGATAAACATCACGTGCTGGATGTACAGAACGGTATACTGTACAAGGGAAACGGGGAAAACCAGTTCATCTCCCAGCAGCCTCCAGTCG TGAGTAGCATCATGGGCAATGGGCGAAGGCGCAGCATTTCCTGCCCCAGTTGCAATGGTCAAGCTGATGGTAACAAGTTACTGGCCCCAGTGGCGCTAGC TTGTGGGATCGATGGCAGTCTGTACGTAGGCGATTTCAACTATGTGCGGCGGATATTCCCTTCTGGAAATGTAACAAGTGTCTTAGAACTAAGAAATAAA GATTTTAGACATAGCAGCAACCCAGCTCATAGATACTACCTTGCAACGGATCCAGTCACGGGAGATCTGTACGTTTCTGACACAAACACCCGCAGAATTT ATCGCCCAAAGTCACTTACGGGGGCAAAAGACTTGACTAAAAATGCAGAAGTCGTCGCAGGGACAGGGGAGCAATGCCTTCCGTTTGACGAGGCGAGATG TGGGGATGGAGGGAAGGCCGTGGAAGCCACACTCATGAGTCCCAAAGGAATGGCAGTTGATAAGAATGGATTAATCTACTTTGTTGATGGAACCATGATT AGGAAAGTTGACCAAAATGGAATCATATCAACTCTTCTGGGCTCTAACGATTTGACTTCAGCCAGACCTTTAACTTGTGACACCAGCATGCACATCAGCC AGGTACGTCTGGAATGGCCCACTGACCTAGCCATTAACCCTATGGATAACTCCATTTATGTCCTGGATAATAATGTAGTTTTACAGATCACTGAAAATCG TCAAGTTCGCATTGCTGCTGGACGGCCCATGCACTGTCAGGTTCCCGGAGTGGAATATCCTGTGGGGAAGCACGCGGTGCAGACAACACTGGAATCAGCC ACTGCCATTGCTGTGTCCTACAGTGGGGTCCTGTACATTACTGAAACTGATGAGAAGAAAATTAACCGGATAAGGCAGGTCACAACAGATGGAGAAATCT CCTTAGTGGCCGGAATACCTTCAGAGTGTGACTGCAAAAATGATGCCAACTGTGACTGTTACCAGAGTGGAGATGGCTACGCCAAGGATGCCAAACTCAG TGCCCCATCCTCCCTGGCTGCTTCTCCAGATGGTACACTGTATATTGCAGATCTAGGGAATATCCGGATCCGGGCTGTGTCAAAGAATAAGCCTTTACTT AACTCTATGAACTTCTATGAAGTTGCGTCTCCAACTGATCAAGAACTCTACATCTTTGACATCAATGGTACTCACCAATATACTGTAAGTTTAGTCACTG GTGATTACCTTTACAATTTTAGCTACAGCAATGACAATGATATTACTGCTGTGACAGACAGCAATGGCAACACCCTTAGAATTAGACGGGACCCAAATCG CATGCCAGTTCGAGTGGTGTCTCCTGATAACCAAGTGATATGGTTGACAATAGGAACAAATGGATGTTTGAAAAGCATGACTGCTCAAGGACTGGAATTA GTTTTGTTTACTTACCATGGCAATAGTGGCCTTTTAGCCACTAAAAGTGATGAAACTGGATGGACAACGTTTTTTGACTATGACAGTGAAGGTCGTCTGA CAAATGTTACGTTTCCAACTGGAGTGGTCACAAACCTGCATGGGGACATGGACAAGGCTATCACAGTGGACATTGAGTCATCTAGCCGAGAAGAAGATGT CAGCATCACTTCAAATCTGTCCTCGATCGATTCTTTCTACACCATGGTTCAAGATCAGTTAAGAAACAGCTACCAGATTGGTTATGACGGCTCCCTCAGA ATTATCTACGCCAGTGGCCTGGACTCACACTACCAAACAGAGCCGCACGTTCTGGCTGGCACCGCTAATCCGACGGTTGCCAAAAGAAACATGACTTTGC CTGGCGAGAACGGTCAAAACTTGGTGGAATGGAGATTCCGAAAAGAGCAAGCCCAAGGGAAAGTCAATGTCTTTGGCCGCAAGCTCAGGGTTAATGGCAG AAACCTCCTTTCAGTTGACTTTGATCGAACAACAAAGACAGAAAAGATCTATGACGACCACCGTAAATTTCTACTGAGGATCGCCTACGACACGTCTGGG CACCCGACTCTCTGGCTGCCAAGCAGCAAGCTGATGGCCGTCAATGTCACCTATTCATCCACAGGTCAAATTGCCAGCATCCAGCGAGGCACCACTAGCG AGAAAGTAGATTATGACGGACAGGGGAGGATCGTGTCTCGGGTCTTTGCTGATGGTAAAACATGGAGTTACACATATTTAGAAAAGTCCATGGTTCTTCT GCTTCATAGCCAGCGGCAGTACATCTTCGAATACGATATGTGGGACCGCCTGTCTGCCATCACCATGCCCAGTGTGGCTCGCCACACCATGCAGACCATC CGATCCATTGGCTACTACCGCAACATATACAACCCCCCGGAAAGCAACGCCTCCATCATCACGGACTACAACGAGGAAGGGCTGCTTCTACAAACAGCTT TCTTGGGTACAAGTCGGAGGGTCTTATTCAAATACAGAAGGCAGACTAGGCTCTCAGAAATTTTATATGATAGCACAAGAGTCAGTTTTACCTATGATGA AACAGCAGGAGTCCTAAAGACAGTAAACCTCCAGAGTGATGGTTTTATTTGCACCATTAGATACAGGCAAATTGGTCCCCTGATTGACAGGCAGATTTTC CGCTTTAGTGAAGATGGGATGGTAAATGCAAGATTTGACTATAGCTATGACAACAGCTTTCGAGTGACCAGCATGCAGGGTGTGATCAATGAAACGCCAC TGCCTATTGATCTGTATCAGTTTGATGACATTTCTGGCAAAGTTGAGCAGTTTGGAAAGTTTGGAGTTATATATTATGATATTAACCAGATCATTTCTAC AGCTGTAATGACCTATACGAAGCACTTTGATGCTCATGGCCGTATCAAGGAGATTCAATATGAGATATTCAGGTCGCTCATGTACTGGATTACAATTCAG TATGATAACATGGGTCGGGTAACCAAGAGAGAGATTAAAATAGGGCCCTTTGCCAACACCACCAAATATGCTTATGAATATGATGTTGATGGACAGCTCC AAACAGTTTACCTCAATGAAAAGATAATGTGGCGGTACAACTACGATCTGAATGGAAACCTCCATTTACTGAACCCAAGTAACAGTGCGCGTCTGACACC CCTTCGCTATGACCTGCGAGACAGAATCACTCGACTGGGTGATGTTCAATATCGGTTGGATGAAGATGGTTTCCTACGTCAAAGGGGCACGGAAATCTTT GAATATAGCTCCAAGGGGCTTCTAACTCGAGTTTACAGTAAAGGCAGTGGCTGGACAGTGATCTACCGTTATGACGGCCTGGGAAGGCGTGTTTCTAGCA AAACCAGTCTAGGACAGCACCTGCAGTTTTTTTATGCTGACTTAACTTATCCCACTAGGATTACTCATGTCTACAACCATTCGAGTTCAGAAATTACCTC CCTGTATTATGATCTCCAAGGACATCTTTTTGCCATGGAAATCAGCAGTGGGGATGAATTCTATATTGCATCGGATAACACAGGGACACCACTGGCTGTG TTCAGTAGCAATGGGCTTATGCTGAAACAGATTCAGTACACTGCATATGGGGAAATCTATTTTGACTCTAATATTGACTTTCAACTGGTAATTGGATTTC ATGGTGGCCTGTATGACCCACTCACCAAATTAATCCACTTTGGAGAAAGAGATTATGACATTTTGGCAGGACGGTGGACAACACCTGACATAGAAATCTG GAAAAGAATTGGGAAGGACCCAGCTCCTTTTAACTTGTACATGTTTAGGAATAACAACCCTGCAAGCAAAATCCATGACGTGAAAGATTACATCACAGAT GTTAACAGCTGGCTGGTGACATTTGGTTTCCATCTGCACAATGCTATTCCTGGATTCCCTGTTCCCAAATTTGATTTAACAGAACCTTCTTACGAACTTG TGAAGAGTCAGCAGTGGGATGATATACCGCCCATCTTCGGAGTCCAGCAGCAAGTGGCGCGGCAGGCCAAGGCCTTCCTGTCGCTGGGGAAGATGGCCGA GGTGCAGGTGAGCCGGCGCCGGGCCGGCGGCGCGCAGTCCTGGCTGTGGTTCGCCACGGTCAAGTCGCTGATCGGCAAGGGCGTCATGCTGGCCGTCAGC CAGGGCCGCGTGCAGACCAACGTGCTCAACATCGCCAACGAGGACTGCATCAAGGTGGCGGCCGTGCTCAACAACGCCTTCTACCTGGAGAACCTGCACT TCACCATCGAGGGCAAGGACACGCACTACTTCATCAAGACCACCACGCCCGAGAGCGACCTGGGCACGCTGCGGTTGACCAGCGGCCGCAAGGCGCTGGA GAACGGCATCAACGTGACGGTGTCGCAGTCCACCACGGTGGTGAACGGCAGGACGCGCAGGTTCGCGGACGTGGAGATGCAGTTCGGCGCGCTGGCGCTG CACGTGCGCTACGGCATGACCCTGGACGAGGAGAAGGCGCGCATCCTGGAGCAGGCGCGGCAGCGCGCGCTCGCCCGGGCCTGGGCGCGCGAGCAGCAGC GCGTGCGCGACGGCGAGGAGGGCGCGCGCCTCTGGACGGAGGGCGAGAAGCGGCAGCTGCTGAGCGCCGGCAAGGTGCAGGGCTACGACGGGTACTACGT ACTCTCGGTGGAGCAGTACCCCGAGCTGGCCGACAGCGCCAACAACATCCAGTTCCTGCGGCAGAGCGAGATCGGCAGGAGGTAACGCCCGGGCCGCGCC CGCCGAGCCGCTCACGCCCTGCCCACATTGTCCTGTGGCACAACCCGAGTGGGACTCTCCAACGCCCAAGAGCCTTCCTCCCGGGGGAATGAGACTGCTG TTACGACCCACACCCACACCGCGAAAACAAGGACCGCTTTTTTCCGAATGACCTTAAAGGTGATCGGCTTTAACGAATATGTTTACATATGCATAGCGCT GCACTCAGTCGGACTGAACGTAGCCAGAGGAAAAAAAAATCATCAAGGACAAAGGCCTCGACCTGTTGCGCTGGGCCGTCTGTTCCTTCTAGGCACTGTA TTTAACTAACTTTAAAAAAGAAAAAAAAATGTGTACAGTGTTTCCAAATAGTCCCGAATTGTCGACCTTTGCTTACAAGAAGTAGTCTGTCTGCATAGGA TGTGATAGCTATCTCTGTTCATTTTACAATGTGGGGCAAAGTTACTGTTTCTAGACAACCCAACTGCTTTCCCTGTGCAGCTTTGTAGAAGGACATTGGC ACAGTGACTTCTGCGGCGGGGATTTATTAATGGATTTTACAATGCTAACGTGGTTTCCCTTCGGGGAAAAAACTGGCAACTAGAATCCTTGTCACTGATA AGCAAAGGAAATCCTGATTTTTTTGTAAATTATGTGAGACAAGTTGTTTATGGATTTTTATATGAATTACAATTTACTGTACATCAAATCTTAGTCTCAG AGGAGTTAATTTATGTAAAGTGTTTAAAAATTTATACTTAAAAATAAAATGATAAAAACGTGAACTGTGTGATTTTTTTAAAAGGATTGCACCTTTTGTT ATCTGTTATAGCTGTACAGTATGAATTATTATATTGTAGAGATATAACAACTTATGCCTATAATGTCCAGAAGTGTTAATATTTTTGTATTAGGTTGAAA AAATGTGCAAGCTTCTATCACTAGATGGATAGGACCGTGCAATTCTAGGTGGGTGGCGAATCAGAGAGCTCCTTTCTCTTCCCTCTCTCACGCATCAGGC CAGTGTCCTCAGCATTGTCAACTGAGAGGCACAGTAGACAACTAGGGCTGGTGGAATGTAAGGGAAGAAGATTGAAAAAACGGGAGGAAGGGTTCTCTGG CCCTCTCTCAACCTTGCAAGTCAATGGGGAGTTGTTGATATAATTAACCCCGAGGTTTTTACTGTTACTGTTCCAAAGCTCTGTCTCTTGATGGAGGAGA GACCACATCAGATGCTGGGGAAATAGGAGGAGGAAAGGTTCTGATGTAGTCGTGATCCTAAACACGTGTCTTAAGATCTAGGAAAGACAGCAGAAACCGA GCAGTGGTGGGTGAGCCAGATGGAGCCGGTCAGGGTTACTCTAAGCCCACATGACCAAACCATCTTGGGGGGCTGGTTTGAATGACAGCCTCTGCTCTGT CTCGGGGAAGCCGGGGGTGGCAGATCCAGCTGGAAGTGAACTGACAGCCGCGCCCTCCTGCACACATGCATGCACGCGTGTGGGAACGAGCCCAGCCGCC ATCTGCACTTCCGTGTCGGCTCAGCTCTGACAAATCTCTTTCCTGAGCACTAAATTCAGCCACGAAAATATTTTTAGAAGATATTTCTCAGTTCATCGAG CTATAGTACACACTGTTTTCCTCTATGTATAATGGTGATAAAATATAGCAAGTGAACATGTCGTAAATATAAAGGTTCAAGTGATGTATTGAAAATAATT TTCTAACTGCTTTGTATGTATCACATACTCTAAATTGCACAGTAGGCGTGTTTATTAAACAGATGATTGGCTGGGAAAGTTTCAAAATAGCTACTGAATT TACAGTATCAGTGCTATTACTGTCTTTGTGTATTTGGTAGAGCATACCGAAGTAATTAATCTTCTAATGAATGCTGATGATATTTTATTAGAATGAAAGC ACAGATTAGCATTAATATTTTTTATTCTGGAAATCCTTTGGCAAGTATTATGAAGCCCAAATTTAGAAAACTATGAGATTTCAAACCACATAAACATGAT TCTGTTTTCCATTTTATTTTTTAACTGTTAGGTATTTGCAGTTCTGTTCCGTGGAACTTCTGCAGGCCTGTATTTAGCATGCTGTAAGTACTTTTGGGTG AAATAGGCTCTGAGTCTAAATTCTCAGACATGTTTCTGATGTATTACCATGAAAAGCTTGTGCCACATGACAGAAGTGAGATCATAGTCTTAACCTCTTC TTGACGTGGACTGGTCTTCACTCGGGCACCGATAAATAACAGATTTGGAGTATCTCCTGGTGCTTATTTTAGATGATGAAGTCAAATCAACCCAATTAGT GTCCTGTTAGTAGGTATAATGAGCCTATTTCTTTCTAAAAAGACTTGTGATCTGGACATGCTTTTACAAGAAATAGTGACCTTGGGGAATATGTAAACAA AAGACCTTTTTCTAAGAGTTGGGAGGGGGTGGGGGACTGTATAATGAAAAGAATTAGCTTACAAAAAAGAAATTGATATTCAAAGTATTTTAGGCAAAGC CAGTCAAAATGCTTTCATGATATTTTGAGATGTAAATTTTGTCTGATTTGTATTGTTCTTTTCATTTGCCTTCTTAACTTTATATGTGACCTGAATTTTC CATAACTTGATGACTATAGATTGCACCTAGGCATTCCAATAAAAGCCAACCCAATGTG

refseq_ODZ3.F3 (forward primer)
refseq_ODZ3.R3 (reverse primer)
Single exon skipping

Frame 0

TSRTDVHTEGMKYGCERTQALLLPDQEQTREGT ALHKFLRRQ*GVPGTHTEVLQFQRDIESF*S*FL AAALRQQSEGFGSQRSRRVH*TRTEFYPKAVRS L*TSNSKRTGILCGNGAPSQRLLYQCRVRC*Y* K*SSDVPRACHETLGQGGQIRPQLLPVKSVQLSP HPDRYGARKQVRQ*E*ATCKQSRPVYPAALAAF P*AALCTASSIHHFSQQKLPDQ*KEPESGPAGC FARRAANHTRVRPAAGQLGPWQ*CTTGKQAFPIQ NRNRYNATVQYCNPRIHNGIWLCLFTTYSATT* KHPIKKCF*IQEVFKVL*LEMHCTVCRRGLGAP GNTPVLFYSNASLWPQLAATAD*K*HI*EWKSEF *YHANKHCVITFWRQWKIRWIYARK*HHRFRRT *YWPKSNSRDSSRDLLEITALH*SATVS*IQYL SSEGCIDWSIWPERLTAFPYSV*LRGAPGWQQAD CQRAAEPA*DGESRAAGEIRQPS*GRLYPVLGF WNLASGFL**WEKCRAGVF*YHCYRVCGGMSPK LPWKWRMRFWNLPLFSRISGSGLFKSRLSSVM*W QRAVLQGPLPVFQRLEGHRV*CADYPVY*PTVW GSWDLYHGLLCLQLRIQRRKL*RS*LYRPWVF* SWCVYPRGMSLQSRMGR*QL*NTEDHVSRPVLRP RNVSSRKWLLHV*P*LDWPRLLKRNMFCGLWLT RRLHGGDVSL*RRLDGPSL*SESLPPPLCRARD LQGWQV*MQPGLEWRALHYRSLFG*DS*RGLSWS VQQQWKMYPGPKWLALCVPAWMERSRL*RSHGD SLHR*QGQ*RRWTH*LHGSRLLPTEFLPESALL SGTAGSSGHH*PKPSIAFSASCQILL*SNQFPYR I**HPCYTWRKSFQ*EPCICHQRPSTDC*WNST YWSKCLVFPLPRIWIYYYPPGRNV*LGGKWWGL SNFGI*TIPIPHSVSYCVDSMECLLCDGYPSHEE RRE*YSQL*SEWIREAKSHHCVITFIHLFQIFS *RQSHHSRNTGTPRGNYNSRNRFETLLLEFQSC RV*VSSQDHHDPVYYSI*FNEGSSYGSCSRKTLP KVVSCLTKLGLYFHMG*NRCI*SESLWSI*SCC VSWI*V*VVFGPDSVGKEDCHSAGL*IGCVQHG WLDIR*TSRAGCTERYTVQGKRGKPVHLPAASSR E*HHGQWAKAQHFLPQLQWSS*W*QVTGPSGAS LWDRWQSVRRRFQLCAADIPFWKCNKCLRTKK* RF*T*QQPSS*ILPCNGSSHGRSVRF*HKHPQNL SPKVTYGGKRLD*KCRSRRRDRGAMPSV*RGEM WGWREGRGSHTHESQRNGS**EWINLLC*WNHD *ES*PKWNHINSSGL*RFDFSQTFNL*HQHAHQP GTSGMAH*PSH*PYG*LHLCPG**CSFTDH*KS SSSHCCWTAHALSGSRSGISCGEARGADNTGIS HCHCCVLQWGPVHY*N**EEN*PDKAGHNRWRNL LSGRNTFRV*LQK*CQL*LLPEWRWLRQGCQTQ CPILPGCFSRWYTVYCRSREYPDPGCVKE*AFT *LYELL*SCVSN*SRTLHL*HQWYSPIYCKFSHW *LPLQF*LQQ*Q*YYCCDRQQWQHP*N*TGPKS HASSSGVS**PSDMVDNRNKWMFEKHDCSRTGI SFVYLPWQ*WPFSH*K**NWMDNVF*L*Q*RSSD KCYVSNWSGHKPAWGHGQGYHSGH*VI*PRRRC QHHFKSVLDRFFLHHGSRSVKKQLPDWL*RLPQ NYLRQWPGLTLPNRAARSGWHR*SDGCQKKHDFA WRERSKLGGMEIPKRASPRESQCLWPQAQG*WQ KPPFS*L*SNNKDRKDL*RPP*ISTEDRLRHVW APDSLAAKQQADGRQCHLFIHRSNCQHPARHH*R ESRL*RTGEDRVSGLC*W*NMELHIFRKVHGSS AS*PAAVHLRIRYVGPPVCHHHAQCGSPHHADH PIHWLLPQHIQPPGKQRLHHHGLQRGRAASTNSF LGYKSEGLIQIQKAD*ALRNFI**HKSQFYL** NSRSPKDSKPPE*WFYLHH*IQANWSPD*QADF PL**RWDGKCKI*L*L*QQLSSDQHAGCDQ*NAT AY*SVSV**HFWQS*AVWKVWSYIL*Y*PDHFY SCNDLYEAL*CSWPYQGDSI*DIQVAHVLDYNS V**HGSGNQERD*NRALCQHHQICL*I*C*WTAP NSLPQ*KDNVAVQLRSEWKPPFTEPK*QCASDT PSL*PARQNHSTG*CSISVG*RWFPTSKGHGNL *I*LQGASNSSLQ*RQWLDSDLPL*RPGKACF*Q NQSRTAPAVFLC*LNLSH*DYSCLQPFEFRNYL PVL*SPRTSFCHGNQQWG*ILYCIG*HRDTTGC VQ*QWAYAETDSVHCIWGNLF*L*Y*LSTGNWIS WWPV*PTHQINPLWRKRL*HFGRTVDNT*HRNL EKNWEGPSSF*LVHV*E*QPCKQNP*RERLHHR C*QLAGDIWFPSAQCYSWIPCSQI*FNRTFLRTC EESAVG*YTAHLRSPAASGAAGQGLPVAGEDGR GAGEPAPGRRRAVLAVVRHGQVADRQGRHAGRQ PGPRADQRAQHRQRGLHQGGGRAQQRLLPGEPAL HHRGQGHALLHQDHHARERPGHAAVDQRPQGAG ERHQRDGVAVHHGGERQDAQVRGRGDAVRRAGA ARALRHDPGRGEGAHPGAGAAARARPGLGARAAA RARRRGGRAPLDGGREAAAAERRQGAGLRRVLR TLGGAVPRAGRQRQQHPVPAAERDRQEVTPGPR PPSRSRPAHIVLWHNPSGTLQRPRAFLPGE*DCC YDPHPHRENKDRFFPNDLKGDRL*RICLHMHSA ALSRTERSQRKKKSSRTKASTCCAGPSVPSRHC I*LTLKKKKKCVQCFQIVPNCRPLLTRSSLSA*D VIAISVHFTMWGKVTVSRQPNCFPCAAL*KDIG TVTSAAGIY*WILQC*RGFPSGKKLATRILVTD KQRKS*FFCKLCETSCLWIFI*ITIYCTSNLSLR GVNLCKVFKNLYLKIK**KRELCDFFKRIAPFV ICYSCTV*IIIL*RYNNLCL*CPEVLIFLY*VE KMCKLLSLDG*DRAILGGWRIRELLSLPSLTHQA SVLSIVN*EAQ*TTRAGGM*GKKIEKTGGRVLW PSLNLASQWGVVDIINPEVFTVTVPKLCLLMEE RPHQMLGK*EEERF*CSRDPKHVS*DLGKTAETE QWWVSQMEPVRVTLSPHDQTILGGWFE*QPLLC LGEAGGGRSSWK*TDSRALLHTCMHACGNEPSR HLHFRVGSALTNLFPEH*IQPRKYF*KIFLSSSS YSTHCFPLCIMVIKYSK*TCRKYKGSSDVLKII F*LLCMYHIL*IAQ*ACLLNR*LAGKVSK*LLN LQYQCYYCLCVFGRAYRSN*SSNEC**YFIRMKA QISINIFYSGNPLASIMKPKFRKL*DFKPHKHD SVFHFIF*LLGICSSVPWNFCRPVFSML*VLLG EIGSESKFSDMFLMYYHEKLVPHDRSEIIVLTSS *RGLVFTRAPINNRFGVSPGAYFR**SQINPIS VLLVGIMSLFLSKKTCDLDMLLQEIVTLGNM*T KDLFLRVGRGWGTV**KELAYKKEIDIQSILGKA SQNAFMIF*DVNFV*FVLFFSFAFLTLYVT*IF HNLMTIDCT*AFQ*KPTQC

Frame 1

PAGLMCTQKE*SMDVKERRPYCSLTKSRREKER RYTNSSADNEECRVPTQKSYSSSETLKAFDHDS SRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGV CEPATRRGLAFCAEMGLPHRGYSISAGSDADTE NEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSA LTLTDTEHENKSDSENEQPASNQGQSTLQPLPPS HKQHSAQHHPSITSLNRNSLTNRRNQSPAPPAA LPAELQTTPESVQLQDSWVLGSNVPLESRHFLF KTGTGTTPLFSTATPGYTMASGSVYSPPTRPLPR NTLSRSAFKFKKSSKYCSWKCTALCAVGVSVLL AILLSYFIAMHLFGLNWQLQQTENDTFENGKVN SDTMPTNTVSLPSGDNGKLGGFTQENNTIDSGEL DIGRRAIQEIPPGIFWRSQLFIDQPQFLKFNIS LQKDALIGVYGRKGLPPSHTQYDFVELLDGSRL IAREQRSLLETERAGRQARSVSLHEAGFIQYLDS GIWHLAFYNDGKNAEQVSFNTIVIESVVECPRN CHGNGECVSGTCHCFPGFLGPDCSRAACPVLCS GNGQYSKGRCLCFSGWKGTECDVPTTQCIDPQCG GRGICIMGSCACNSGYKGESCEEADCIDPGCSN HGVCIHGECHCSPGWGGSNCEILKTMCPDQCSG HGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSH GVCMGGTCRCEEGWTGPACNQRACHPRCAEHGT CKDGKCECSQGWNGEHCTIAHYLDKIVKEGCPG LCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMET LCTDSKDNEGDGLIDCMDPDCCLQSSCQNQPYC RGLPDPQDIISQSLQSPSQQAAKSFYDRISFLI GSDSTHVIPGESPFNKSLASVIRGQVLTADGTPL IGVNVSFFHYPEYGYTITRQDGMFDLVANGGAS LTLVFERSPFLTQYHTVWIPWNVFYVMDTLVMK KEENDIPSCDLSGFVRPNPIIVSSPLSTFFRSSP EDSPIIPETQVLHEETTIPGTDLKLSYLSSRAA GYKSVLKITMTQSIIPFNLMKVHLMVAVVGRLF QKWFPASPNLAYTFIWDKTDAYNQKVYGLSEAVV SVGYEYESCLDLTLWEKRTAILQGYELDASNMG GWTLDKHHVLDVQNGILYKGNGENQFISQQPPV VSSIMGNGRRRSISCPSCNGQADGNKLLAPVALA CGIDGSLYVGDFNYVRRIFPSGNVTSVLELRNK DFRHSSNPAHRYYLATDPVTGDLYVSDTNTRRI YRPKSLTGAKDLTKNAEVVAGTGEQCLPFDEARC GDGGKAVEATLMSPKGMAVDKNGLIYFVDGTMI RKVDQNGIISTLLGSNDLTSARPLTCDTSMHIS QVRLEWPTDLAINPMDNSIYVLDNNVVLQITENR QVRIAAGRPMHCQVPGVEYPVGKHAVQTTLESA TAIAVSYSGVLYITETDEKKINRIRQVTTDGEI SLVAGIPSECDCKNDANCDCYQSGDGYAKDAKLS APSSLAASPDGTLYIADLGNIRIRAVSKNKPLL NSMNFYEVASPTDQELYIFDINGTHQYTVSLVT GDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNR MPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLEL VLFTYHGNSGLLATKSDETGWTTFFDYDSEGRL TNVTFPTGVVTNLHGDMDKAITVDIESSSREEDV SITSNLSSIDSFYTMVQDQLRNSYQIGYDGSLR IIYASGLDSHYQTEPHVLAGTANPTVAKRNMTL PGENGQNLVEWRFRKEQAQGKVNVFGRKLRVNGR NLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSG HPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTS EKVDYDGQGRIVSRVFADGKTWSYTYLEKSMVLL LHSQRQYIFEYDMWDRLSAITMPSVARHTMQTI RSIGYYRNIYNPPESNASIITDYNEEGLLLQTA FLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDE TAGVLKTVNLQSDGFICTIRYRQIGPLIDRQIF RFSEDGMVNARFDYSYDNSFRVTSMQGVINETP LPIDLYQFDDISGKVEQFGKFGVIYYDINQIIST AVMTYTKHFDAHGRIKEIQYEIFRSLMYWITIQ YDNMGRVTKREIKIGPFANTTKYAYEYDVDGQL QTVYLNEKIMWRYNYDLNGNLHLLNPSNSARLTP LRYDLRDRITRLGDVQYRLDEDGFLRQRGTEIF EYSSKGLLTRVYSKGSGWTVIYRYDGLGRRVSS KTSLGQHLQFFYADLTYPTRITHVYNHSSSEITS LYYDLQGHLFAMEISSGDEFYIASDNTGTPLAV FSSNGLMLKQIQYTAYGEIYFDSNIDFQLVIGF HGGLYDPLTKLIHFGERDYDILAGRWTTPDIEIW KRIGKDPAPFNLYMFRNNNPASKIHDVKDYITD VNSWLVTFGFHLHNAIPGFPVPKFDLTEPSYEL VKSQQWDDIPPIFGVQQQVARQAKAFLSLGKMAE VQVSRRRAGGAQSWLWFATVKSLIGKGVMLAVS QGRVQTNVLNIANEDCIKVAAVLNNAFYLENLH FTIEGKDTHYFIKTTTPESDLGTLRLTSGRKALE NGINVTVSQSTTVVNGRTRRFADVEMQFGALAL HVRYGMTLDEEKARILEQARQRALARAWAREQQ RVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYV LSVEQYPELADSANNIQFLRQSEIGRR*RPGRA RRAAHALPTLSCGTTRVGLSNAQEPSSRGNETA VTTHTHTAKTRTAFFRMTLKVIGFNEYVYICIAL HSVGLNVARGKKNHQGQRPRPVALGRLFLLGTV FN*L*KRKKNVYSVSK*SRIVDLCLQEVVCLHR M**LSLFILQCGAKLLFLDNPTAFPVQLCRRTLA Q*LLRRGFINGFYNANVVSLRGKNWQLESLSLI SKGNPDFFVNYVRQVVYGFLYELQFTVHQILVS EELIYVKCLKIYT*K*NDKNVNCVIFLKGLHLLL SVIAVQYELLYCRDITTYAYNVQKC*YFCIRLK KCASFYH*MDRTVQF*VGGESESSFLFPLSRIR PVSSALSTERHSRQLGLVECKGRRLKKREEGFSG PLSTLQVNGELLI*LTPRFLLLLFQSSVS*WRR DHIRCWGNRRRKGSDVVVILNTCLKI*ERQQKP SSGG*ARWSRSGLL*AHMTKPSWGAGLNDSLCSV SGKPGVADPAGSELTAAPSCTHACTRVGTSPAA ICTSVSAQL*QISFLSTKFSHENIFRRYFSVHR AIVHTVFLYV*W**NIASEHVVNIKVQVMY*K*F SNCFVCITYSKLHSRRVY*TDDWLGKFQNSY*I YSISAITVFVYLVEHTEVINLLMNADDILLE*K HRLALIFFILEILWQVL*SPNLENYEISNHINMI LFSILFFNC*VFAVLFRGTSAGLYLACCKYFWV K*ALSLNSQTCF*CITMKSLCHMTEVRS*S*PL LDVDWSSLGHR*ITDLEYLLVLILDDEVKSTQLV SC**V**AYFFLKRLVIWTCFYKK**PWGICKQ KTFF*ELGGGGGLYNEKN*LTKKKLIFKVF*AK PVKMLS*YFEM*ILSDLYCSFHLPS*LYM*PEFS IT**L*IAPRHSNKSQPNV

Frame 2

QQD*CAHRRNEVWM*KNAGLTAP*PRADERRNG ATQIPPQTMRSAGYPHRSPTVPARH*KLLIMIP RGCFTATE*RIWFTEKQTSSLDKDRILP*GS*E FVNQQLEEDWHFVRKWGSLTEVTLSVQGQMLILK MKQ*CPQSMP*DFGAGGSNQAAAPACQVGPTQP SP*QIRSTKTSPTVRMSNLQAIKASLPCSPCRL PISSTLHSIIHPSLLSTETP*PIEGTRVRPRRLL CPPSCKPHPSPSSCRTAGSLAVMYHWKAGISYS KQEQVQRHCSVLQPQDTQWHLALFIHHLLGHYL ETPYQEVLLNSRSLQSTVAGNALHCVP*GSRCSW QYSCLIL*QCISLASTGSYSRLKMTHLRMEK*I LIPCQQTLCHYLLETMEN*VDLRKKITP*IPEN LILAEEQFKRFLPGSSGDHSSSLISHSFLNSISL FRRMH*LEYMAGKAYRLPILSMTSWSSWMAAG* LPESSGACLRRREPGGRRDPSAFMRPALSSTWI LESGIWLFIMMGKMQSRCLLIPLL*SLWWNVPEI AMEMENAFLELAIVFQDFWVRIVQEPPVQCYVV ATGSTPRAAACVSAAGRAPSVMCRLPSVLTHSV GVVGFVSWALVLATQDTKEKVVKKLTV*TLGVLI MVCVSTGNVTAVQDGEVAIVKY*RPCVQTSAPA TERIFKKVAPARVTLTGLAQTAQTKYVLWTVAH TAFAWGGRVAVKKAGRAQPVIREPATPAVPSTGP ARMASVNAARAGMESTALSLTIWIR*LKRVVLV CATAMEDVPWTKMAGIVCASLDGEEQAVT*PWR LFAQIARTMKEMDSLTAWIPIAAYRVPARISPIV GDCRILRTSLAKAFNRLLSKLPNPFMIESVSL* DLIAPMLYLEKVLSIRALHLSSEAKY*LLMELH LLE*MSRFSITQNMDILLPARTECLTWWQMVGPL *LWYLNDPHSSLSIILCGFHGMSFM*WIP*S*R KKRMIFPAVI*VDS*GQIPSLCHHLYPPFSDLL LKTVPSFPKHRYSTRKLQFQEQI*NSPT*VPELQ GISQFSRSP*PSLLFHLI**RFILW*L**EDSS KSGFLPHQTWPILSYGIKQMHIIRKSMVYLKLL CQLDMSMSRVWT*LCGKRGLPFCRAMNWMRPTWV AGH*INITCWMYRTVYCTRETGKTSSSPSSLQS *VASWAMGEGAAFPAPVAMVKLMVTSYWPQWR* LVGSMAVCT*AISTMCGGYSLLEM*QVS*N*EIK ILDIAATQLIDTTLQRIQSREICTFLTQTPAEF IAQSHLRGQKT*LKMQKSSQGQGSNAFRLTRRD VGMEGRPWKPHS*VPKEWQLIRMD*STLLMEP*L GKLTKMESYQLFWALTI*LQPDL*LVTPACTSA RYVWNGPLT*PLTLWITPFMSWIIM*FYRSLKI VKFALLLDGPCTVRFPEWNILWGSTRCRQHWNQP LPLLCPTVGSCTLLKLMRRKLTG*GRSQQMEKS P*WPEYLQSVTAKMMPTVTVTRVEMATPRMPNS VPHPPWLLLQMVHCILQI*GISGSGLCQRISLYL TL*TSMKLRLQLIKNSTSLTSMVLTNIL*V*SL VITFTILATAMTMILLL*QTAMATPLELDGTQI ACQFEWCLLITK*YG*Q*EQMDV*KA*LLKDWN* FCLLTMAIVAF*PLKVMKLDGQRFLTMTVKVV* QMLRFQLEWSQTCMGTWTRLSQWTLSHLAEKKM SASLQICPRSILSTPWFKIS*ETATRLVMTAPSE LSTPVAWTHTTKQSRTFWLAPLIRRLPKET*LC LARTVKTWWNGDSEKSKPKGKSMSLAASSGLMA ETSFQLTLIEQQRQKRSMTTTVNFY*GSPTTRLG TRLSGCQAAS*WPSMSPIHPQVKLPASSEAPLA RK*IMTDRGGSCLGSLLMVKHGVTHI*KSPWFF CFIASGSTSSNTICGTACLPSPCPVWLATPCRPS DPLATTATYTTPRKATPPSSRTTTRKGCFYKQL SWVQVGGSYSNTEGRLGSQKFYMIAQESVLPMM KQQES*RQ*TSRVMVLFAPLDTGKLVP*LTGRFS ALVKMGW*MQDLTIAMTTAFE*PACRV*SMKRH CLLICISLMTFLAKLSSLESLELYIMILTRSFL QL**PIRSTLMLMAVSRRFNMRYSGRSCTGLQFS MITWVG*PRERLK*GPLPTPPNMLMNMMLMDSS KQFTSMKR*CGGTTTI*METSIY*TQVTVRV*H PFAMTCETESLDWVMFNIGWMKMVSYVKGARKSL NIAPRGF*LEFTVKAVAGQ*STVMTAWEGVFLA KPV*DSTCSFFMLT*LIPLGLLMSTTIRVQKLP PCIMISKDIFLPWKSAVGMNSILHRITQGHHWLC SVAMGLC*NRFSTLHMGKSILTLILTFNW*LDF MVACMTHSPN*STLEKEIMTFWQDGGQHLT*KS GKELGRTQLLLTCTCLGITTLQAKSMT*KITSQM LTAGW*HLVSICTMLFLDSLFPNLI*QNLLTNL *RVSSGMIYRPSSESSSKWRGRPRPSCRWGRWP RCR*AGAGPAARSPGCGSPRSSR*SARASCWPSA RAACRPTCSTSPTRTASRWRPCSTTPSTWRTCT SPSRARTRTTSSRPPRPRATWARCG*PAAARRW RTAST*RCRSPPRW*TAGRAGSRTWRCSSARWRC TCATA*PWTRRRRASWSRRGSARSPGPGRASSS ACATARRARASGRRARSGSC*APARCRATTGTT YSRWSSTPSWPTAPTTSSSCGRARSAGGNARAAP AEPLTPCPHCPVAQPEWDSPTPKSLPPGGMRLL LRPTPTPRKQGPLFSE*P*R*SALTNMFTYA*R CTQSD*T*PEEKKIIKDKGLDLLRWAVCSF*ALY LTNFKKEKKMCTVFPNSPELSTFAYKK*SVCIG CDSYLCSFYNVGQSYCF*TTQLLSLCSFVEGHW HSDFCGGDLLMDFTMLTWFPFGEKTGN*NPCH** AKEILIFL*IM*DKLFMDFYMNYNLLYIKS*SQ RS*FM*SV*KFILKNKMIKT*TV*FF*KDCTFC YLL*LYSMNYYIVEI*QLMPIMSRSVNIFVLG*K NVQASITRWIGPCNSRWVANQRAPFSSLSHASG QCPQHCQLRGTVDN*GWWNVREED*KNGRKGSL ALSQPCKSMGSC*YN*PRGFYCYCSKALSLDGGE TTSDAGEIGGGKVLM*S*S*TRVLRSRKDSRNR AVVGEPDGAGQGYSKPT*PNHLGGLV*MTASAL SRGSRGWQIQLEVN*QPRPPAHMHARVWERAQPP SALPCRLSSDKSLS*ALNSATKIFLEDISQFIE L*YTLFSSMYNGDKI*QVNMS*I*RFK*CIENN FLTALYVSHTLNCTVGVFIKQMIGWESFKIATEF TVSVLLLSLCIW*SIPK*LIF**MLMIFY*NES TD*H*YFLFWKSFGKYYEAQI*KTMRFQTT*T* FCFPFYFLTVRYLQFCSVELLQACI*HAVSTFG* NRL*V*ILRHVSDVLP*KACAT*QK*DHSLNLF LTWTGLHSGTDK*QIWSISWCLF*MMKSNQPN* CPVSRYNEPISF*KDL*SGHAFTRNSDLGEYVNK RPFSKSWEGVGDCIMKRISLQKRN*YSKYFRQS QSKCFHDILRCKFCLICIVLFICLLNFICDLNF P*LDDYRLHLGIPIKANPM