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Sequences

Sequence NM_001040424

CGCTGCCCCGTCCACGCCGCCCGCGCCCCGCAGTCCCACCCGCAGGACCCCCGGCCGCGCCAGGGTCTCGCCTGCGCCCCCCGCGCCCGCCCGCGGACTA CAAGTCCCGCCATGCCCCGCCGCCGCCCCCCGGCTTCCGGTGCTGCGCAGTTTCCGGAGCGGATCGCAACCCGGAGTCCGGATCCGATCCCGCTCTGCAC ATTCCAAAGGCAGGTGTCAGAGATGGCTGAAGATGGGAGCGAAGAGATCATGTTCATCTGGTGTGAAGACTGCAGCCAGTACCACGACTCCGAATGTCCC GAGCTGGGCCCAGTGGTCATGGTCAAAGACTCCTTTGTGTTAAGCAGGGCAAGGTCATCCCTTCCTCCCAACTTGGAGATCAGACGACTGGAAGATGGAG CCGAGGGGGTGTTCGCCATCACTCAGCTCGTCAAGCGGACACAGTTCGGTCCCTTTGAGTCCAGGAGGGTCGCCAAATGGGAAAAGGAGTCTGCATTTCC CCTGAAGGTGTTCCAGAAGGACGGGCACCCCGTGTGCTTCGACACCTCCAACGAGGATGACTGCAACTGGATGATGCTGGTGCGGCCAGCGGCGGAGGCC GAGCACCAGAACCTGACGGCCTACCAGCACGGCAGCGACGTGTACTTCACCACCTCCAGAGACATCCCCCCGGGTACCGAGCTGCGCGTGTGGTATGCGG CCTTCTATGCCAAGAAGATGGACAAGCCCATGCTGAAGCAGGCCGGCTCTGGCGTCCACGCTGCAGGCACCCCAGAAAACAGCGCCCCCGTGGAGTCGGA GCCCAGCCAGTGGGCGTGTAAAGTGTGTTCTGCCACCTTCCTGGAGCTGCAGCTCCTCAATGAACATCTGTTGGGCCACTTAGAACAAGCCAAAAGCCTT CCTCCAGGCAGCCAAAGCGAGGCAGCAGCTCCCGAGAAGGAGCAGGACACACCCCGGGGGGAACCCCCTGCAGTGCCCGAGAGCGAGAATGTTGCCACCA AAGAACAGAAGAAAAAGCCTCGAAGGGGGAGAAAACCCAAAGTGTCCAAAGCTGAGCAGCCTCTAGTCATCGTGGAAGACAAGGAACCCACAGAGCAAGT GGCAGAGATCATTACCGAGGTCCCTCCGGATGAGCCTGTGAGTGCAACGCCAGATGAGCGGATCATGGAGCTGGTTCTGGGGAAGCTGGCCACCACCACC ACTGACACCAGCTCGGTTCCAAAGTTCACCCATCATCAGAATAACACCATCACGCTCAAGAGGAGCTTAATTCTCTCAAGCAGACACGGCATCCGGCGCA AGCTCATCAAACAGCTCGGGGAGCACAAGCGGGTTTACCAGTGCAATATCTGCAGCAAGATCTTCCAGAACAGCAGCAACCTGAGCAGGCACGTGCGCTC GCATGGTGACAAGCTGTTTAAGTGCGAAGAGTGTGCAAAATTGTTCAGCCGCAAAGAGAGCCTAAAGCAGCACGTTTCCTACAAGCACAGCAGGAACGAG GTGGACGGCGAGTACAGGTACCGCTGCGGCACTTGTGAGAAGACCTTCCGCATCGAGAGCGCGCTGGAGTTCCACAACTGCAGGACAGATGACAAGACGT TCCAATGTGAGATGTGTTTCAGATTCTTCTCCACCAACAGCAACCTCTCCAAGCACAAGAAGAAGCACGGCGACAAGAAGTTTGCCTGTGAGGTCTGCAG CAAGATGTTCTACCGCAAGGACGTCATGCTGGACCACCAGCGCCGGCACCTGGAAGGAGTGCGGCGAGTGAAGCGAGAGGACCTGGAGGCCGGTGGGGAG AACCTGGTCCGTTACAAGAAGGAGCCTTCCGGGTGCCCGGTGTGTGGCAAGGTGTTCTCCTGCCGGAGCAATATGAACAAGCACCTGCTCACCCACGGCG ACAAGAAGTACACCTGCGAGATCTGCGGGCGCAAGTTCTTCCGCGTGGATGTGCTCAGGGACCACATCCATGTCCACTTCAAGGACATCGCGTTGATGGA TGACCACCAGAGGGAAGAGTTTATCGGCAAGATCGGGATCTCCTCGGAAGAAAACGATGACAATTCTGACGAGAGCGCAGACTCGGAGCCTCACAAGTAC AGCTGCAAGCGGTGCCAGCTCACCTTCGGCCGGGGGAAGGAGTACCTGAAGCACATCATGGAGGTGCACAAGGAGAAGGGCTATGGCTGCAGCATCTGCA ACCGGCGCTTTGCACTGAAGGCCACCTACCACGCCCACATGGTCATCCACCGTGAAAACCTGCCGGACCCCAACGTGCAGAAGTACATCCACCCCTGCGA GATCTGCGGGCGGATCTTCAACAGCATCGGGAACCTGGAGCGCCACAAGCTCATCCACACAGGTGTGAAGAGCCACGCCTGCGAGCAGTGTGGGAAGTCC TTTGCCAGGAAGGACATGCTGAAGGAGCACATGCGTGTGCACGACAATGTCCGCGAGTACCTGTGTGCCGAGTGTGGGAAAGGCATGAAGACCAAGCACG CGCTGCGCCACCACATGAAGCTGCACAAGGGCATCAAGGAGTACGAGTGCAAGGAGTGCCACCGCAGGTTCGCGCAGAAGGTCAACATGCTCAAGCACTG CAAGCGGCACACGGGGATTAAAGATTTCATGTGTGAATTGTGTGGGAAGACATTCAGCGAGAGGAACACCATGGAGACCCACAAGCTCATCCACACAGTG GGCAAGCAGTGGACGTGCTCCGTGTGCGACAAGAAGTACGTGACCGAGTACATGCTGCAGAAGCACGTTCAGCTCACACACGACAAGGTGGAGGCGCAGA GCTGCCAGCTGTGCGGGACCAAGGTGTCCACCAGGGCCTCCATGAGCCGACACATGCGGCGCAAGCACCCCGAGGTGCTCGCGGTGAGGATCGATGACCT GGACCACCTCCCGGAGACCACCACCATCGACGCCTCCTCCATTGGCATCGTCCAGCCTGAGCTGACTCTGGAGCAGGAGGATTTGGCCGAAGGGAAGCAC GGGAAAGCTGCCAAGCGAAGTCACAAGAGAAAGCAGAAGCCAGAAGAGGAGGCGGGTGCTCCGGTGCCCGAGGACGCCACCTTCAGCGAATACTCAGAGA AAGAGACGGAGTTCACAGGCAGTGTAGGCGACGAGACCAATTCCGCAGTACAGAGCATTCAGCAGGTAGTGGTGACCCTGGGTGACCCAAATGTGACCAC ACCATCGAGCTCAGTCGGCTTAACCAACATCACCGTGACCCCCATCACCACTGCGGCCGCGACTCAGTTTACCAATCTCCAGCCGGTGGCCGTGGGGCAC CTTACCACCCCTGAACGCCAGTTACAGCTGGACAACTCAATCCTGACCGTGACCTTTGATACCGTCAGCGGCTCTGCCATGTTGCACAACCGCCAAAATG ACGTCCAGATCCACCCCCAGCCGGAAGCCTCGAACCCACAGTCTGTGGCCCATTTCATCAACCTGACGACCCTGGTCAACTCCATCACGCCCCTGGGGAG CCAGCTTAGTGACCAGCACCCGCTCACGTGGCGGGCAGTGCCCCAGACTGACGTCTTGCCACCCTCGCAGCCGCAGGCACCCCCACAGCAGGCGGCCCAG CCCCAGGTGCAGGCGGAGCAGCAGCAGCAGCAGATGTACAGCTACTGAGCTGCGTTCCGGGAGACTCGGGGCAAGAACTGCAGAGGGATGTTTGGGATTT GTTTAGATGTGTTTGCTGGATACCAAACAAACAAAAAGTCATACATTGCAATGTAAGGTTGACTTAGCTTTGCAGAGTATCTCCAGATCCCCCGCCAGCA ACCATTACGGTCTGTCAGCTTAACTCTAGAAGGGACCTCTGGCAGGCCAGAGTTTTAAACTGGATGGGGCTCCACACCATGCCTTACCAAGGCAGTAAGT CCTGGGCCGGGGCCGCATCTGCCTCCCCTTACAGAACCAGTGTTCGCCCGACACAGGGTTCGGGAAAGTGAAGCTGAGAGAGAAGCAGGATTTTAAGAGG CAGGAGATAAGTTATTAGGAACACAAATGGTTCATTTTCTTTTTTCTTTTAGAGCTCGGTTCCTATGAGAACACAGACAGTATTCACAGGTGGCAGCAGG CAGCAGGGAACATTTTCTCCTCACTTCTGGATTTTTTTGCAAGCGAGCACATAGAAGTTAAAGTAACGTGTATTCTCTTTGAACTAGGAGTGGAGTCGGT TCTTATACAACTATGGGCTGAAACCATGAGGCGTGCTGAGCCGCACCTGATCCTGCAACCTTCGAGGTCATCACGGTCATCATGTGCAAGGGGTCACGTG AGGTCACTGACTCCAGCTCAAAACGCATCTTAGTAATATCCATGAATCGATTTCCAATAGAGTTTTTTTCCTTTTTTTTTTTTAACTTTATTTCAAACAT ACATTATGTGTTCAAGACTGTTATGGCCAATATTGTGTTTTAGTTTTATGTTAACATGATAAAGTCATGTGCACTGTAGGACCATCTGTCCCTGTCCACC CTTCACAGCTGCCCAGATGCAGAGGGTCGCGCGGCTGTGTGTGAGGAGTGAGCCTCCCTGCTGCCCCCAGGGGCTCCTCCGGGTTGTCTCAGGATTCTCT GCAATCCAAATGTATCCATTCTGGCTGAAGCCCAGCCAGAATCCCGAGTGGAAGAAACGGGGGAAAAGTCATATTTTCCTTCTGTTTAAACTTCAATTCC AAAGGTTGGTGTATTTCATGACCAGTTTTCTATAAAAATATTGAATGAGTTTGGCTCTTTACAATGGAAAAGTGTAGGTATTTCTGAAACACAGAGAAAA TGCTATTTCCTGCCAGGTGGTAATGAAAGCAGAGAGGTTAGTTCACTAATAGAAGCATTAATTGCCCCTAAAACTGAATGTGCGGTGAACAGCCAGGTCT GCGTGTGCGGGGACACGTGCTGTCACGTCTGTGTACCAGTTTCGGGGGCAGGGGCCAGGGTTGGGGGAGGCACCCAGCCCTCCTGCTGCCCACGACAAGA AACACTGAGAGGTGTGGGGAGAAGTTTGCTCTTAACTTTCCTGGTACTCTGTTTGTGGCCACAGTGAGAGGACAAACCTGCCTTAAGGTGTCCTGCTTTG CCAGTTATCCCAGATCCTGCACTCACTGGGAGTCCATCTTGAGGAAACACTGGCATGGCTGAGTAATTGATCAGGAGCAGTCCTGATGTTGCCAGCAGAA CAAAGGATGATTGTGTTTTTCAAAACGCAACTTTCTCAGCACTTCACTCCAAACAGCAGACTTTTGAGGACAGGGCTGGAATTTGTTTTGTGCAATATAT GCCTTCATGAACTAAGGAATGTTCATCCCCAGGCAGCATGCAGGAGGGTCTGTGGGGCTCACCTCCTCACCTTACCCACCATCACTCGCGCCTAGCTCTC ACCTCTCAGTTGAATGAATAGTGGGAGATCATTTGACTTTTAATTTATGAGAATTATTTTATGTTATTTATGTATATAATTAACTGTTTTATACATAGTA GTCTCATCAAATGAATTCGGGCTTGGGGTGATATTGTCTCCATTCTCCAGATACAAGTGCTCCAGGCATCCATGGAATCAGCAGGAGACCAGGGCTCCTA AGATATATTTTTAAAAATCAGTATCGATTTCTTTTTGCCTTTGCAGAATCTAAAGGGCAAATGACCTCGCAGAGACTCCCAACGGGCTTTGGGCTCATGA CGAAACACCCACTAGCATTGATCTTTTATTCCTCTTCCCTATAAAATAAAGGCCTTGGAAATCACAATTTTATTTTTTTAAAGAAGTTGTTTTAGTGCCT AGAGTAAGACCGCATCAAATGTTGTTAAAGAACCTAATTTAGATTGTGTGGTATATACCACTGTTTATCTCAATACACAGACACCTCTTACTTCTTGTTA TAAGTGAGAACTCTAAAGAAAAATCAAACTCCCAAGTTTTCTGTAAACATACGTGGTCTTAATAGGGTCACTGTCTGAGGCAAAATGGGTTGTCTTAAAG CAATTGCTACAAATTTGCATCAAAGAAACTAGATAGCAAAATACAACAACCATGTACCACCCAGGCAGAAGAGTCCTCACCTATACGCAGTTCTGCATAT TGATCATCATGACAGGAAGTATTTCGTTTTTTAACTGATCCCAGGTGCACAGATGTATTCATAAAGGAAGACATTAGATCCAGCCATTGTGGCCACCAGG CTCTGTGGACCCATCTCAGTGGAGAATTCGTTTTGGACCCGTGGCTCCGTGCAGCTGTGGACTCGAGTGCCATCCACTGGTGTGAGTCTTGCGGGGAGGC CACAGGTACAGCTGCTCCCCGTGAATCCTGGTCTGTGGGTTGAGAAGGGGCTCGGGCCTCTGGAATGCTCTAGCGTGTGACGTGTTCTCAGGAAAACGTT CTGTGCCAAGTGCCGCCTCGCTGTGTCCGGCATGGGACTGCGCTGGAGGGTCCGGCGTGGAAGGCAGACCTCCTGTACCTCTATCGTTCCCATTTGTGGC ATCCAAAGGCGGAAGGCTCATGGCTTCCCCACTAGAGGCGGCGTCTTGGGCTTTCCCATTGGATTGTGAAAGGCATTAAGACTGTTTGGAGATGTTGGCT GTATTTCCTGTCACATCAGGTTGTATGATGACGAATAAAAGGTGCTGTGACCCGTGTTTTCAA

refseq_PRDM15.F2 (forward primer)
refseq_PRDM15.R2 (reverse primer)
Single exon skipping

Frame 0

RCPVHAARAPQSHPQDPRPRQGLACAPRARPRT TSPAMPRRRPPASGAAQFPERIATRSPDPIPLCT FQRQVSEMAEDGSEEIMFIWCEDCSQYHDSECP ELGPVVMVKDSFVLSRARSSLPPNLEIRRLEDG AEGVFAITQLVKRTQFGPFESRRVAKWEKESAFP LKVFQKDGHPVCFDTSNEDDCNWMMLVRPAAEA EHQNLTAYQHGSDVYFTTSRDIPPGTELRVWYA AFYAKKMDKPMLKQAGSGVHAAGTPENSAPVESE PSQWACKVCSATFLELQLLNEHLLGHLEQAKSL PPGSQSEAAAPEKEQDTPRGEPPAVPESENVAT KEQKKKPRRGRKPKVSKAEQPLVIVEDKEPTEQV AEIITEVPPDEPVSATPDERIMELVLGKLATTT TDTSSVPKFTHHQNNTITLKRSLILSSRHGIRR KLIKQLGEHKRVYQCNICSKIFQNSSNLSRHVRS HGDKLFKCEECAKLFSRKESLKQHVSYKHSRNE VDGEYRYRCGTCEKTFRIESALEFHNCRTDDKT FQCEMCFRFFSTNSNLSKHKKKHGDKKFACEVCS KMFYRKDVMLDHQRRHLEGVRRVKREDLEAGGE NLVRYKKEPSGCPVCGKVFSCRSNMNKHLLTHG DKKYTCEICGRKFFRVDVLRDHIHVHFKDIALMD DHQREEFIGKIGISSEENDDNSDESADSEPHKY SCKRCQLTFGRGKEYLKHIMEVHKEKGYGCSIC NRRFALKATYHAHMVIHRENLPDPNVQKYIHPCE ICGRIFNSIGNLERHKLIHTGVKSHACEQCGKS FARKDMLKEHMRVHDNVREYLCAECGKGMKTKH ALRHHMKLHKGIKEYECKECHRRFAQKVNMLKHC KRHTGIKDFMCELCGKTFSERNTMETHKLIHTV GKQWTCSVCDKKYVTEYMLQKHVQLTHDKVEAQ SCQLCGTKVSTRASMSRHMRRKHPEVLAVRIDDL DHLPETTTIDASSIGIVQPELTLEQEDLAEGKH GKAAKRSHKRKQKPEEEAGAPVPEDATFSEYSE KETEFTGSVGDETNSAVQSIQQVVVTLGDPNVTT PSSSVGLTNITVTPITTAAATQFTNLQPVAVGH LTTPERQLQLDNSILTVTFDTVSGSAMLHNRQN DVQIHPQPEASNPQSVAHFINLTTLVNSITPLGS QLSDQHPLTWRAVPQTDVLPPSQPQAPPQQAAQ PQVQAEQQQQQMYSY*AAFRETRGKNCRGMFGI CLDVFAGYQTNKKSYIAM*G*LSFAEYLQIPRQQ PLRSVSLTLEGTSGRPEF*TGWGSTPCLTKAVS PGPGPHLPPLTEPVFARHRVRESEAEREAGF*E AGDKLLGTQMVHFLFSFRARFL*EHRQYSQVAAG SREHFLLTSGFFCKRAHRS*SNVYSL*TRSGVG SYTTMG*NHEAC*AAPDPATFEVITVIMCKGSR EVTDSSSKRILVISMNRFPIEFFSFFFFNFISNI HYVFKTVMANIVF*FYVNMIKSCAL*DHLSLST LHSCPDAEGRAAVCEE*ASLLPPGAPPGCLRIL CNPNVSILAEAQPESRVEETGEKSYFPSV*TSIP KVGVFHDQFSIKILNEFGSLQWKSVGISETQRK CYFLPGGNESREVSSLIEALIAPKTECAVNSQV CVCGDTCCHVCVPVSGAGARVGGGTQPSCCPRQE TLRGVGRSLLLTFLVLCLWPQ*EDKPALRCPAL PVIPDPALTGSPS*GNTGMAE*LIRSSPDVASR TKDDCVFQNATFSALHSKQQTFEDRAGICFVQYM PS*TKECSSPGSMQEGLWGSPPHLTHHHSRLAL TSQLNE*WEII*LLIYENYFMLFMYIINCFIHS SLIK*IRAWGDIVSILQIQVLQASMESAGDQGS* DIFLKISIDFFLPLQNLKGK*PRRDSQRALGS* RNTH*H*SFIPLPYKIKALEITILFF*RSCFSA *SKTASNVVKEPNLDCVVYTTVYLNTQTPLTSCY K*EL*RKIKLPSFL*TYVVLIGSLSEAKWVVLK QLLQICIKETR*QNTTTMYHPGRRVLTYTQFCI LIIMTGSISFFN*SQVHRCIHKGRH*IQPLWPPG SVDPSQWRIRFGPVAPCSCGLECHPLV*VLRGG HRYSCSP*ILVCGLRRGSGLWNALACDVFSGKR SVPSAASLCPAWDCAGGSGVEGRPPVPLSFPFVA SKGGRLMASPLEAASWAFPLDCERH*DCLEMLA VFPVTSGCMMTNKRCCDPCFQ

Frame 1

AAPSTPPAPRSPTRRTPGRARVSPAPPAPARGL QVPPCPAAAPRLPVLRSFRSGSQPGVRIRSRSA HSKGRCQRWLKMGAKRSCSSGVKTAASTTTPNVP SWAQWSWSKTPLC*AGQGHPFLPTWRSDDWKME PRGCSPSLSSSSGHSSVPLSPGGSPNGKRSLHF P*RCSRRTGTPCASTPPTRMTATG*CWCGQRRRP STRT*RPTSTAATCTSPPPETSPRVPSCACGMR PSMPRRWTSPC*SRPALASTLQAPQKTAPPWSR SPASGRVKCVLPPSWSCSSSMNICWAT*NKPKAF LQAAKARQQLPRRSRTHPGGNPLQCPRARMLPP KNRRKSLEGGENPKCPKLSSL*SSWKTRNPQSK WQRSLPRSLRMSL*VQRQMSGSWSWFWGSWPPPP LTPARFQSSPIIRITPSRSRGA*FSQADTASGA SSSNSSGSTSGFTSAISAARSSRTAAT*AGTCA RMVTSCLSAKSVQNCSAAKRA*SSTFPTSTAGTR WTASTGTAAALVRRPSASRARWSSTTAGQMTRR SNVRCVSDSSPPTATSPSTRRSTATRSLPVRSA ARCSTARTSCWTTSAGTWKECGE*SERTWRPVGR TWSVTRRSLPGARCVARCSPAGAI*TSTCSPTA TRSTPARSAGASSSAWMCSGTTSMSTSRTSR*W MTTRGKSLSARSGSPRKKTMTILTRAQTRSLTST AASGASSPSAGGRST*STSWRCTRRRAMAAASA TGALH*RPPTTPTWSSTVKTCRTPTCRSTSTPA RSAGGSSTASGTWSATSSSTQV*RATPASSVGSP LPGRTC*RSTCVCTTMSASTCVPSVGKA*RPST RCATT*SCTRASRSTSARSATAGSRRRSTCSST ASGTRGLKISCVNCVGRHSARGTPWRPTSSSTQW ASSGRAPCATRST*PSTCCRSTFSSHTTRWRRR AASCAGPRCPPGPP*ADTCGASTPRCSR*GSMT WTTSRRPPPSTPPPLASSSLS*LWSRRIWPKGST GKLPSEVTRESRSQKRRRVLRCPRTPPSANTQR KRRSSQAV*ATRPIPQYRAFSR*W*PWVTQM*P HHRAQSA*PTSP*PPSPLRPRLSLPISSRWPWGT LPPLNASYSWTTQS*P*PLIPSAALPCCTTAKM TSRSTPSRKPRTHSLWPISST*RPWSTPSRPWG ASLVTSTRSRGGQCPRLTSCHPRSRRHPHSRRPS PRCRRSSSSSRCTATELRSGRLGARTAEGCLGF V*MCLLDTKQTKSHTLQCKVDLALQSISRSPAS NHYGLSA*L*KGPLAGQSFKLDGAPHHALPRQ*V LGRGRICLPLQNQCSPDTGFGKVKLREKQDFKR QEISY*EHKWFIFFFLLELGSYENTDSIHRWQQ AAGNIFSSLLDFFASEHIEVKVTCILFELGVESV LIQLWAETMRRAEPHLILQPSRSSRSSCARGHV RSLTPAQNAS**YP*IDFQ*SFFPFFFLTLFQT YIMCSRLLWPILCFSFMLT**SHVHCRTICPCPP FTAAQMQRVARLCVRSEPPCCPQGLLRVVSGFS AIQMYPFWLKPSQNPEWKKRGKSHIFLLFKLQF QRLVYFMTSFL*KY*MSLALYNGKV*VFLKHREN AISCQVVMKAERLVH**KH*LPLKLNVR*TARS ACAGTRAVTSVYQFRGQGPGLGEAPSPPAAHDK KH*EVWGEVCS*LSWYSVCGHSERTNLP*GVLLC QLSQILHSLGVHLEETLAWLSN*SGAVLMLPAE QRMIVFFKTQLSQHFTPNSRLLRTGLEFVLCNI CLHELRNVHPQAACRRVCGAHLLTLPTITRA*LS PLS*MNSGRSFDF*FMRIILCYLCI*LTVLYIV VSSNEFGLGVILSPFSRYKCSRHPWNQQETRAP KIYF*KSVSISFCLCRI*RANDLAETPNGLWAHD ETPTSIDLLFLFPIK*RPWKSQFYFFKEVVLVP RVRPHQMLLKNLI*IVWYIPLFISIHRHLLLLV ISENSKEKSNSQVFCKHTWS**GHCLRQNGLS*S NCYKFASKKLDSKIQQPCTTQAEESSPIRSSAY *SS*QEVFRFLTDPRCTDVFIKEDIRSSHCGHQ ALWTHLSGEFVLDPWLRAAVDSSAIHWCESCGEA TGTAAPRESWSVG*EGARASGML*RVTCSQENV LCQVPPRCVRHGTALEGPAWKADLLYLYRSHLW HPKAEGSWLPH*RRRLGLSHWIVKGIKTVWRCWL YFLSHQVV**RIKGAVTRVF

Frame 2

LPRPRRPRPAVPPAGPPAAPGSRLRPPRPPADY KSRHAPPPPPGFRCCAVSGADRNPESGSDPALH IPKAGVRDG*RWERRDHVHLV*RLQPVPRLRMS RAGPSGHGQRLLCVKQGKVIPSSQLGDQTTGRWS RGGVRHHSARQADTVRSL*VQEGRQMGKGVCIS PEGVPEGRAPRVLRHLQRG*LQLDDAGAASGGG RAPEPDGLPARQRRVLHHLQRHPPGYRAARVVCG LLCQEDGQAHAEAGRLWRPRCRHPRKQRPRGVG AQPVGV*SVFCHLPGAAAPQ*TSVGPLRTSQKP SSRQPKRGSSSREGAGHTPGGTPCSARERECCHQ RTEEKASKGEKTQSVQS*AASSHRGRQGTHRAS GRDHYRGPSG*ACECNAR*ADHGAGSGEAGHHH H*HQLGSKVHPSSE*HHHAQEELNSLKQTRHPAQ AHQTARGAQAGLPVQYLQQDLPEQQQPEQARAL AW*QAV*VRRVCKIVQPQREPKAARFLQAQQER GGRRVQVPLRHL*EDLPHRERAGVPQLQDR*QDV PM*DVFQILLHQQQPLQAQEEARRQEVCL*GLQ QDVLPQGRHAGPPAPAPGRSAASEARGPGGRWG EPGPLQEGAFRVPGVWQGVLLPEQYEQAPAHPRR QEVHLRDLRAQVLPRGCAQGPHPCPLQGHRVDG *PPEGRVYRQDRDLLGRKR*QF*RERRLGASQV QLQAVPAHLRPGEGVPEAHHGGAQGEGLWLQHLQ PALCTEGHLPRPHGHPP*KPAGPQRAEVHPPLR DLRADLQQHREPGAPQAHPHRCEEPRLRAVWEV LCQEGHAEGAHACARQCPRVPVCRVWERHEDQAR AAPPHEAAQGHQGVRVQGVPPQVRAEGQHAQAL QAAHGD*RFHV*IVWEDIQREEHHGDPQAHPHS GQAVDVLRVRQEVRDRVHAAEARSAHTRQGGGAE LPAVRDQGVHQGLHEPTHAAQAPRGARGEDR*P GPPPGDHHHRRLLHWHRPA*ADSGAGGFGRREA RESCQAKSQEKAEARRGGGCSGARGRHLQRILRE RDGVHRQCRRRDQFRSTEHSAGSGDPG*PKCDH TIELSRLNQHHRDPHHHCGRDSVYQSPAGGRGA PYHP*TPVTAGQLNPDRDL*YRQRLCHVAQPPK* RPDPPPAGSLEPTVCGPFHQPDDPGQLHHAPGE PA**PAPAHVAGSAPD*RLATLAAAGTPTAGGP APGAGGAAAAADVQLLSCVPGDSGQELQRDVWDL FRCVCWIPNKQKVIHCNVRLT*LCRVSPDPPPA TITVCQLNSRRDLWQARVLNWMGLHTMPYQGSK SWAGAASASPYRTSVRPTQGSGK*S*ERSRILRG RR*VIRNTNGSFSFFF*SSVPMRTQTVFTGGSR QQGTFSPHFWIFLQAST*KLK*RVFSLN*EWSR FLYNYGLKP*GVLSRT*SCNLRGHHGHHVQGVT* GH*LQLKTHLSNIHESISNRVFFLFFF*LYFKH TLCVQDCYGQYCVLVLC*HDKVMCTVGPSVPVH PSQLPRCRGSRGCV*GVSLPAAPRGSSGLSQDSL QSKCIHSG*SPARIPSGRNGGKVIFSFCLNFNS KGWCIS*PVFYKNIE*VWLFTMEKCRYF*NTEK MLFPARW**KQRG*FTNRSINCP*N*MCGEQPGL RVRGHVLSRLCTSFGGRGQGWGRHPALLLPTTR NTERCGEKFALNFPGTLFVATVRGQTCLKVSCF ASYPRSCTHWESILRKHWHG*VIDQEQS*CCQQN KG*LCFSKRNFLSTSLQTADF*GQGWNLFCAIY AFMN*GMFIPRQHAGGSVGLTSSPYPPSLAPSS HLSVE*IVGDHLTFNL*ELFYVIYVYN*LFYT** SHQMNSGLG*YCLHSPDTSAPGIHGISRRPGLL RYIFKNQYRFLFAFAESKGQMTSQRLPTGFGLM TKHPLALIFYSSSL*NKGLGNHNFIFLKKLF*CL E*DRIKCC*RT*FRLCGIYHCLSQYTDTSYFLL *VRTLKKNQTPKFSVNIRGLNRVTV*GKMGCLK AIATNLHQRN*IAKYNNHVPPRQKSPHLYAVLHI DHHDRKYFVF*LIPGAQMYS*RKTLDPAIVATR LCGPISVENSFWTRGSVQLWTRVPSTGVSLAGR PQVQLLPVNPGLWVEKGLGPLECSSV*RVLRKTF CAKCRLAVSGMGLRWRVRRGRQTSCTSIVPICG IQRRKAHGFPTRGGVLGFPIGL*KALRLFGDVG CISCHIRLYDDE*KVL*PVFS

Sequence NM_022115

CGCTGCCCCGTCCACGCCGCCCGCGCCCCGCAGTCCCACCCGCAGGACCCCCGGCCGCGCCAGGGTCTCGCCTGCGCCCCCCGCGCCCGCCCGCGGACTA CAAGTCCCGCCATGCCCCGCCGCCGCCCCCCGGCTTCCGGTGCTGCGCAGTTTCCGGAGCGGATCGCAACCCGGAGTCCGGATCCGATCCCGCTCTGCAC ATTCCAAAGGCAGCCGCGCGCCGCCCCGGTCCAGCCGCCATGCCGACTGTTCTTTGTTACATTCGCCGGCTGCGGGCACCGTTGGCGATCGGAGTCAAAA CCCGGCTGGATTTCCCGGAGCCGCTCCGGGATCGCCCTGCGCGCCGCCCGCCCGCCGGGGTCTTCGCCGCCCCGGCCCGCGGCCCCGCGGCCCCCGCCGC CGGGCGGCGTCGTCGCCGAGGCCCCAGGGGATGTCGTTATCCCCCGCCCTCGGGTACAGCCCATGCGGGTCGCACGGGGGGGTCCCTGGACCCCCAACCC CGCGTTTAGAGAAGCTGAGTCCTGGTCCCAGATTGGGAACCAGAGGGTCAGTGAGCAGCTCTTGGAAACATCTCTAGGGAATGAGGTGTCCGACACTGAG CCACTGAGCCCTGCGAGTGCAGGCCTGCGACGCAATCCTGCCCTACCTCCTGGACCCTTTGCACAAAACTTTTCCTGGGGGAACCAGGAAAATCTGCCCC CAGCCCTGGGGAAGATTGCGAACGGAGGAGGAACTGGGGCAGGCAAGGCCGAATGCGGCTATGAAACTGAGTCACACTTGCTAGAGCCGCACGAGATACC TTTGAACGTGAATACACACAAGTTCAGTGACTGTGAGTTTCCATATGAGTTTTGCACGGTCTGCTTTTCACCCTTCAAGCTGCTGGGGATGAGCGGGGTG GAGGGCGTGTGGAATCAGCATTCAAGAAGTGCCAGCATGCACACTTTCCTAAACCACTCAGCAACGGGCATCAGAGAAGCAGGTTGCAGGAAGGACATGC CGGTGTCAGAGATGGCTGAAGATGGGAGCGAAGAGATCATGTTCATCTGGTGTGAAGACTGCAGCCAGTACCACGACTCCGAATGTCCCGAGCTGGGCCC AGTGGTCATGGTCAAAGACTCCTTTGTGTTAAGCAGGGCAAGGTCTTGGCCTGCCAGCGGACACGTGCACACCCAGGCGGGGCAGGGGATGCGGGGTTAT GAGGACAGGGACAGGGCTGACCCACAGCAGCTTCCAGAAGCAGTCCCTGCAGGCCTGGTGAGGCGGCTCAGTGGGCAGCAGCTGCCCTGCCGTTCCACCC TCACCTGGGGGAGGCTGTGCCACCTGGTGGCCCAGGGCAGGTCATCCCTTCCTCCCAACTTGGAGATCAGACGACTGGAAGATGGAGCCGAGGGGGTGTT CGCCATCACTCAGCTCGTCAAGCGGACACAGTTCGGTCCCTTTGAGTCCAGGAGGGTCGCCAAATGGGAAAAGGAGTCTGCATTTCCCCTGAAGGTGTTC CAGAAGGACGGGCACCCCGTGTGCTTCGACACCTCCAACGAGGATGACTGCAACTGGATGATGCTGGTGCGGCCAGCGGCGGAGGCCGAGCACCAGAACC TGACGGCCTACCAGCACGGCAGCGACGTGTACTTCACCACCTCCAGAGACATCCCCCCGGGTACCGAGCTGCGCGTGTGGTATGCGGCCTTCTATGCCAA GAAGATGGACAAGCCCATGCTGAAGCAGGCCGGCTCTGGCGTCCACGCTGCAGGCACCCCAGAAAACAGCGCCCCCGTGGAGTCGGAGCCCAGCCAGTGG GCGTGTAAAGTGTGTTCTGCCACCTTCCTGGAGCTGCAGCTCCTCAATGAACATCTGTTGGGCCACTTAGAACAAGCCAAAAGCCTTCCTCCAGGCAGCC AAAGCGAGGCAGCAGCTCCCGAGAAGGAGCAGGACACACCCCGGGGGGAACCCCCTGCAGTGCCCGAGAGCGAGAATGTTGCCACCAAAGAACAGAAGAA AAAGCCTCGAAGGGGGAGAAAACCCAAAGTGTCCAAAGCTGAGCAGCCTCTAGTCATCGTGGAAGACAAGGAACCCACAGAGCAAGTGGCAGAGATCATT ACCGAGGTCCCTCCGGATGAGCCTGTGAGTGCAACGCCAGATGAGCGGATCATGGAGCTGGTTCTGGGGAAGCTGGCCACCACCACCACTGACACCAGCT CGGTTCCAAAGTTCACCCATCATCAGAATAACACCATCACGCTCAAGAGGAGCTTAATTCTCTCAAGCAGACACGGCATCCGGCGCAAGCTCATCAAACA GCTCGGGGAGCACAAGCGGGTTTACCAGTGCAATATCTGCAGCAAGATCTTCCAGAACAGCAGCAACCTGAGCAGGCACGTGCGCTCGCATGGTGACAAG CTGTTTAAGTGCGAAGAGTGTGCAAAATTGTTCAGCCGCAAAGAGAGCCTAAAGCAGCACGTTTCCTACAAGCACAGCAGGAACGAGGTGGACGGCGAGT ACAGGTACCGCTGCGGCACTTGTGAGAAGACCTTCCGCATCGAGAGCGCGCTGGAGTTCCACAACTGCAGGACAGATGACAAGACGTTCCAATGTGAGAT GTGTTTCAGATTCTTCTCCACCAACAGCAACCTCTCCAAGCACAAGAAGAAGCACGGCGACAAGAAGTTTGCCTGTGAGGTCTGCAGCAAGATGTTCTAC CGCAAGGACGTCATGCTGGACCACCAGCGCCGGCACCTGGAAGGAGTGCGGCGAGTGAAGCGAGAGGACCTGGAGGCCGGTGGGGAGAACCTGGTCCGTT ACAAGAAGGAGCCTTCCGGGTGCCCGGTGTGTGGCAAGGTGTTCTCCTGCCGGAGCAATATGAACAAGCACCTGCTCACCCACGGCGACAAGAAGTACAC CTGCGAGATCTGCGGGCGCAAGTTCTTCCGCGTGGATGTGCTCAGGGACCACATCCATGTCCACTTCAAGGACATCGCGTTGATGGATGACCACCAGAGG GAAGAGTTTATCGGCAAGATCGGGATCTCCTCGGAAGAAAACGATGACAATTCTGACGAGAGCGCAGACTCGGAGCCTCACAAGTACAGCTGCAAGCGGT GCCAGCTCACCTTCGGCCGGGGGAAGGAGTACCTGAAGCACATCATGGAGGTGCACAAGGAGAAGGGCTATGGCTGCAGCATCTGCAACCGGCGCTTTGC ACTGAAGGCCACCTACCACGCCCACATGGTCATCCACCGTGAAAACCTGCCGGACCCCAACGTGCAGAAGTACATCCACCCCTGCGAGATCTGCGGGCGG ATCTTCAACAGCATCGGGAACCTGGAGCGCCACAAGCTCATCCACACAGGTGTGAAGAGCCACGCCTGCGAGCAGTGTGGGAAGTCCTTTGCCAGGAAGG ACATGCTGAAGGAGCACATGCGTGTGCACGACAATGTCCGCGAGTACCTGTGTGCCGAGTGTGGGAAAGGCATGAAGACCAAGCACGCGCTGCGCCACCA CATGAAGCTGCACAAGGGCATCAAGGAGTACGAGTGCAAGGAGTGCCACCGCAGGTTCGCGCAGAAGGTCAACATGCTCAAGCACTGCAAGCGGCACACG GGGATTAAAGATTTCATGTGTGAATTGTGTGGGAAGACATTCAGCGAGAGGAACACCATGGAGACCCACAAGCTCATCCACACAGTGGGCAAGCAGTGGA CGTGCTCCGTGTGCGACAAGAAGTACGTGACCGAGTACATGCTGCAGAAGCACGTTCAGCTCACACACGACAAGGTGGAGGCGCAGAGCTGCCAGCTGTG CGGGACCAAGGTGTCCACCAGGGCCTCCATGAGCCGACACATGCGGCGCAAGCACCCCGAGGTGCTCGCGGTGAGGATCGATGACCTGGACCACCTCCCG GAGACCACCACCATCGACGCCTCCTCCATTGGCATCGTCCAGCCTGAGCTGACTCTGGAGCAGGAGGATTTGGCCGAAGGGAAGCACGGGAAAGCTGCCA AGCGAAGTCACAAGAGAAAGCAGAAGCCAGAAGAGGAGGCGGGTGCTCCGGTGCCCGAGGACGCCACCTTCAGCGAATACTCAGAGAAAGAGACGGAGTT CACAGGCAGTGTAGGCGACGAGACCAATTCCGCAGTACAGAGCATTCAGCAGGTAGTGGTGACCCTGGGTGACCCAAATGTGACCACACCATCGAGCTCA GTCGGCTTAACCAACATCACCGTGACCCCCATCACCACTGCGGCCGCGACTCAGTTTACCAATCTCCAGCCGGTGGCCGTGGGGCACCTTACCACCCCTG AACGCCAGTTACAGCTGGACAACTCAATCCTGACCGTGACCTTTGATACCGTCAGCGGCTCTGCCATGTTGCACAACCGCCAAAATGACGTCCAGATCCA CCCCCAGCCGGAAGCCTCGAACCCACAGTCTGTGGCCCATTTCATCAACCTGACGACCCTGGTCAACTCCATCACGCCCCTGGGGAGCCAGCTTAGTGAC CAGCACCCGCTCACGTGGCGGGCAGTGCCCCAGACTGACGTCTTGCCACCCTCGCAGCCGCAGGCACCCCCACAGCAGGCGGCCCAGCCCCAGGTGCAGG CGGAGCAGCAGCAGCAGCAGATGTACAGCTACTGAGCTGCGTTCCGGGAGACTCGGGGCAAGAACTGCAGAGGGATGTTTGGGATTTGTTTAGATGTGTT TGCTGGATACCAAACAAACAAAAAGTCATACATTGCAATGTAAGGTTGACTTAGCTTTGCAGAGTATCTCCAGATCCCCCGCCAGCAACCATTACGGTCT GTCAGCTTAACTCTAGAAGGGACCTCTGGCAGGCCAGAGTTTTAAACTGGATGGGGCTCCACACCATGCCTTACCAAGGCAGTAAGTCCTGGGCCGGGGC CGCATCTGCCTCCCCTTACAGAACCAGTGTTCGCCCGACACAGGGTTCGGGAAAGTGAAGCTGAGAGAGAAGCAGGATTTTAAGAGGCAGGAGATAAGTT ATTAGGAACACAAATGGTTCATTTTCTTTTTTCTTTTAGAGCTCGGTTCCTATGAGAACACAGACAGTATTCACAGGTGGCAGCAGGCAGCAGGGAACAT TTTCTCCTCACTTCTGGATTTTTTTGCAAGCGAGCACATAGAAGTTAAAGTAACGTGTATTCTCTTTGAACTAGGAGTGGAGTCGGTTCTTATACAACTA TGGGCTGAAACCATGAGGCGTGCTGAGCCGCACCTGATCCTGCAACCTTCGAGGTCATCACGGTCATCATGTGCAAGGGGTCACGTGAGGTCACTGACTC CAGCTCAAAACGCATCTTAGTAATATCCATGAATCGATTTCCAATAGAGTTTTTTTCCTTTTTTTTTTTTAACTTTATTTCAAACATACATTATGTGTTC AAGACTGTTATGGCCAATATTGTGTTTTAGTTTTATGTTAACATGATAAAGTCATGTGCACTGTAGGACCATCTGTCCCTGTCCACCCTTCACAGCTGCC CAGATGCAGAGGGTCGCGCGGCTGTGTGTGAGGAGTGAGCCTCCCTGCTGCCCCCAGGGGCTCCTCCGGGTTGTCTCAGGATTCTCTGCAATCCAAATGT ATCCATTCTGGCTGAAGCCCAGCCAGAATCCCGAGTGGAAGAAACGGGGGAAAAGTCATATTTTCCTTCTGTTTAAACTTCAATTCCAAAGGTTGGTGTA TTTCATGACCAGTTTTCTATAAAAATATTGAATGAGTTTGGCTCTTTACAATGGAAAAGTGTAGGTATTTCTGAAACACAGAGAAAATGCTATTTCCTGC CAGGTGGTAATGAAAGCAGAGAGGTTAGTTCACTAATAGAAGCATTAATTGCCCCTAAAACTGAATGTGCGGTGAACAGCCAGGTCTGCGTGTGCGGGGA CACGTGCTGTCACGTCTGTGTACCAGTTTCGGGGGCAGGGGCCAGGGTTGGGGGAGGCACCCAGCCCTCCTGCTGCCCACGACAAGAAACACTGAGAGGT GTGGGGAGAAGTTTGCTCTTAACTTTCCTGGTACTCTGTTTGTGGCCACAGTGAGAGGACAAACCTGCCTTAAGGTGTCCTGCTTTGCCAGTTATCCCAG ATCCTGCACTCACTGGGAGTCCATCTTGAGGAAACACTGGCATGGCTGAGTAATTGATCAGGAGCAGTCCTGATGTTGCCAGCAGAACAAAGGATGATTG TGTTTTTCAAAACGCAACTTTCTCAGCACTTCACTCCAAACAGCAGACTTTTGAGGACAGGGCTGGAATTTGTTTTGTGCAATATATGCCTTCATGAACT AAGGAATGTTCATCCCCAGGCAGCATGCAGGAGGGTCTGTGGGGCTCACCTCCTCACCTTACCCACCATCACTCGCGCCTAGCTCTCACCTCTCAGTTGA ATGAATAGTGGGAGATCATTTGACTTTTAATTTATGAGAATTATTTTATGTTATTTATGTATATAATTAACTGTTTTATACATAGTAGTCTCATCAAATG AATTCGGGCTTGGGGTGATATTGTCTCCATTCTCCAGATACAAGTGCTCCAGGCATCCATGGAATCAGCAGGAGACCAGGGCTCCTAAGATATATTTTTA AAAATCAGTATCGATTTCTTTTTGCCTTTGCAGAATCTAAAGGGCAAATGACCTCGCAGAGACTCCCAACGGGCTTTGGGCTCATGACGAAACACCCACT AGCATTGATCTTTTATTCCTCTTCCCTATAAAATAAAGGCCTTGGAAATCACAATTTTATTTTTTTAAAGAAGTTGTTTTAGTGCCTAGAGTAAGACCGC ATCAAATGTTGTTAAAGAACCTAATTTAGATTGTGTGGTATATACCACTGTTTATCTCAATACACAGACACCTCTTACTTCTTGTTATAAGTGAGAACTC TAAAGAAAAATCAAACTCCCAAGTTTTCTGTAAACATACGTGGTCTTAATAGGGTCACTGTCTGAGGCAAAATGGGTTGTCTTAAAGCAATTGCTACAAA TTTGCATCAAAGAAACTAGATAGCAAAATACAACAACCATGTACCACCCAGGCAGAAGAGTCCTCACCTATACGCAGTTCTGCATATTGATCATCATGAC AGGAAGTATTTCGTTTTTTAACTGATCCCAGGTGCACAGATGTATTCATAAAGGAAGACATTAGATCCAGCCATTGTGGCCACCAGGCTCTGTGGACCCA TCTCAGTGGAGAATTCGTTTTGGACCCGTGGCTCCGTGCAGCTGTGGACTCGAGTGCCATCCACTGGTGTGAGTCTTGCGGGGAGGCCACAGGTACAGCT GCTCCCCGTGAATCCTGGTCTGTGGGTTGAGAAGGGGCTCGGGCCTCTGGAATGCTCTAGCGTGTGACGTGTTCTCAGGAAAACGTTCTGTGCCAAGTGC CGCCTCGCTGTGTCCGGCATGGGACTGCGCTGGAGGGTCCGGCGTGGAAGGCAGACCTCCTGTACCTCTATCGTTCCCATTTGTGGCATCCAAAGGCGGA AGGCTCATGGCTTCCCCACTAGAGGCGGCGTCTTGGGCTTTCCCATTGGATTGTGAAAGGCATTAAGACTGTTTGGAGATGTTGGCTGTATTTCCTGTCA CATCAGGTTGTATGATGACGAATAAAAGGTGCTGTGACCCGTGTTTTCAA

refseq_PRDM15.F2 (forward primer)
refseq_PRDM15.R2 (reverse primer)
Single exon skipping

Frame 0

RCPVHAARAPQSHPQDPRPRQGLACAPRARPRT TSPAMPRRRPPASGAAQFPERIATRSPDPIPLCT FQRQPRAAPVQPPCRLFFVTFAGCGHRWRSESK PGWISRSRSGIALRAARPPGSSPPRPAAPRPPP PGGVVAEAPGDVVIPRPRVQPMRVARGGPWTPNP AFREAESWSQIGNQRVSEQLLETSLGNEVSDTE PLSPASAGLRRNPALPPGPFAQNFSWGNQENLP PALGKIANGGGTGAGKAECGYETESHLLEPHEIP LNVNTHKFSDCEFPYEFCTVCFSPFKLLGMSGV EGVWNQHSRSASMHTFLNHSATGIREAGCRKDM PVSEMAEDGSEEIMFIWCEDCSQYHDSECPELGP VVMVKDSFVLSRARSWPASGHVHTQAGQGMRGY EDRDRADPQQLPEAVPAGLVRRLSGQQLPCRST LTWGRLCHLVAQGRSSLPPNLEIRRLEDGAEGVF AITQLVKRTQFGPFESRRVAKWEKESAFPLKVF QKDGHPVCFDTSNEDDCNWMMLVRPAAEAEHQN LTAYQHGSDVYFTTSRDIPPGTELRVWYAAFYAK KMDKPMLKQAGSGVHAAGTPENSAPVESEPSQW ACKVCSATFLELQLLNEHLLGHLEQAKSLPPGS QSEAAAPEKEQDTPRGEPPAVPESENVATKEQKK KPRRGRKPKVSKAEQPLVIVEDKEPTEQVAEII TEVPPDEPVSATPDERIMELVLGKLATTTTDTS SVPKFTHHQNNTITLKRSLILSSRHGIRRKLIKQ LGEHKRVYQCNICSKIFQNSSNLSRHVRSHGDK LFKCEECAKLFSRKESLKQHVSYKHSRNEVDGE YRYRCGTCEKTFRIESALEFHNCRTDDKTFQCEM CFRFFSTNSNLSKHKKKHGDKKFACEVCSKMFY RKDVMLDHQRRHLEGVRRVKREDLEAGGENLVR YKKEPSGCPVCGKVFSCRSNMNKHLLTHGDKKYT CEICGRKFFRVDVLRDHIHVHFKDIALMDDHQR EEFIGKIGISSEENDDNSDESADSEPHKYSCKR CQLTFGRGKEYLKHIMEVHKEKGYGCSICNRRFA LKATYHAHMVIHRENLPDPNVQKYIHPCEICGR IFNSIGNLERHKLIHTGVKSHACEQCGKSFARK DMLKEHMRVHDNVREYLCAECGKGMKTKHALRHH MKLHKGIKEYECKECHRRFAQKVNMLKHCKRHT GIKDFMCELCGKTFSERNTMETHKLIHTVGKQW TCSVCDKKYVTEYMLQKHVQLTHDKVEAQSCQLC GTKVSTRASMSRHMRRKHPEVLAVRIDDLDHLP ETTTIDASSIGIVQPELTLEQEDLAEGKHGKAA KRSHKRKQKPEEEAGAPVPEDATFSEYSEKETEF TGSVGDETNSAVQSIQQVVVTLGDPNVTTPSSS VGLTNITVTPITTAAATQFTNLQPVAVGHLTTP ERQLQLDNSILTVTFDTVSGSAMLHNRQNDVQIH PQPEASNPQSVAHFINLTTLVNSITPLGSQLSD QHPLTWRAVPQTDVLPPSQPQAPPQQAAQPQVQ AEQQQQQMYSY*AAFRETRGKNCRGMFGICLDVF AGYQTNKKSYIAM*G*LSFAEYLQIPRQQPLRS VSLTLEGTSGRPEF*TGWGSTPCLTKAVSPGPG PHLPPLTEPVFARHRVRESEAEREAGF*EAGDKL LGTQMVHFLFSFRARFL*EHRQYSQVAAGSREH FLLTSGFFCKRAHRS*SNVYSL*TRSGVGSYTT MG*NHEAC*AAPDPATFEVITVIMCKGSREVTDS SSKRILVISMNRFPIEFFSFFFFNFISNIHYVF KTVMANIVF*FYVNMIKSCAL*DHLSLSTLHSC PDAEGRAAVCEE*ASLLPPGAPPGCLRILCNPNV SILAEAQPESRVEETGEKSYFPSV*TSIPKVGV FHDQFSIKILNEFGSLQWKSVGISETQRKCYFL PGGNESREVSSLIEALIAPKTECAVNSQVCVCGD TCCHVCVPVSGAGARVGGGTQPSCCPRQETLRG VGRSLLLTFLVLCLWPQ*EDKPALRCPALPVIP DPALTGSPS*GNTGMAE*LIRSSPDVASRTKDDC VFQNATFSALHSKQQTFEDRAGICFVQYMPS*T KECSSPGSMQEGLWGSPPHLTHHHSRLALTSQL NE*WEII*LLIYENYFMLFMYIINCFIHSSLIK* IRAWGDIVSILQIQVLQASMESAGDQGS*DIFL KISIDFFLPLQNLKGK*PRRDSQRALGS*RNTH *H*SFIPLPYKIKALEITILFF*RSCFSA*SKTA SNVVKEPNLDCVVYTTVYLNTQTPLTSCYK*EL *RKIKLPSFL*TYVVLIGSLSEAKWVVLKQLLQ ICIKETR*QNTTTMYHPGRRVLTYTQFCILIIMT GSISFFN*SQVHRCIHKGRH*IQPLWPPGSVDP SQWRIRFGPVAPCSCGLECHPLV*VLRGGHRYS CSP*ILVCGLRRGSGLWNALACDVFSGKRSVPSA ASLCPAWDCAGGSGVEGRPPVPLSFPFVASKGG RLMASPLEAASWAFPLDCERH*DCLEMLAVFPV TSGCMMTNKRCCDPCFQ

Frame 1

AAPSTPPAPRSPTRRTPGRARVSPAPPAPARGL QVPPCPAAAPRLPVLRSFRSGSQPGVRIRSRSA HSKGSRAPPRSSRHADCSLLHSPAAGTVGDRSQN PAGFPGAAPGSPCAPPARRGLRRPGPRPRGPRR RAASSPRPQGMSLSPALGYSPCGSHGGVPGPPT PRLEKLSPGPRLGTRGSVSSSWKHL*GMRCPTLS H*ALRVQACDAILPYLLDPLHKTFPGGTRKICP QPWGRLRTEEELGQARPNAAMKLSHTC*SRTRY L*T*IHTSSVTVSFHMSFARSAFHPSSCWG*AGW RACGISIQEVPACTLS*TTQQRASEKQVAGRTC RCQRWLKMGAKRSCSSGVKTAASTTTPNVPSWA QWSWSKTPLC*AGQGLGLPADTCTPRRGRGCGVM RTGTGLTHSSFQKQSLQAW*GGSVGSSCPAVPP SPGGGCATWWPRAGHPFLPTWRSDDWKMEPRGC SPSLSSSSGHSSVPLSPGGSPNGKRSLHFP*RCS RRTGTPCASTPPTRMTATG*CWCGQRRRPSTRT *RPTSTAATCTSPPPETSPRVPSCACGMRPSMP RRWTSPC*SRPALASTLQAPQKTAPPWSRSPASG RVKCVLPPSWSCSSSMNICWAT*NKPKAFLQAA KARQQLPRRSRTHPGGNPLQCPRARMLPPKNRR KSLEGGENPKCPKLSSL*SSWKTRNPQSKWQRSL PRSLRMSL*VQRQMSGSWSWFWGSWPPPPLTPA RFQSSPIIRITPSRSRGA*FSQADTASGASSSN SSGSTSGFTSAISAARSSRTAAT*AGTCARMVTS CLSAKSVQNCSAAKRA*SSTFPTSTAGTRWTAS TGTAAALVRRPSASRARWSSTTAGQMTRRSNVR CVSDSSPPTATSPSTRRSTATRSLPVRSAARCST ARTSCWTTSAGTWKECGE*SERTWRPVGRTWSV TRRSLPGARCVARCSPAGAI*TSTCSPTATRST PARSAGASSSAWMCSGTTSMSTSRTSR*WMTTRG KSLSARSGSPRKKTMTILTRAQTRSLTSTAASG ASSPSAGGRST*STSWRCTRRRAMAAASATGAL H*RPPTTPTWSSTVKTCRTPTCRSTSTPARSAGG SSTASGTWSATSSSTQV*RATPASSVGSPLPGR TC*RSTCVCTTMSASTCVPSVGKA*RPSTRCAT T*SCTRASRSTSARSATAGSRRRSTCSSTASGTR GLKISCVNCVGRHSARGTPWRPTSSSTQWASSG RAPCATRST*PSTCCRSTFSSHTTRWRRRAASC AGPRCPPGPP*ADTCGASTPRCSR*GSMTWTTSR RPPPSTPPPLASSSLS*LWSRRIWPKGSTGKLP SEVTRESRSQKRRRVLRCPRTPPSANTQRKRRS SQAV*ATRPIPQYRAFSR*W*PWVTQM*PHHRAQ SA*PTSP*PPSPLRPRLSLPISSRWPWGTLPPL NASYSWTTQS*P*PLIPSAALPCCTTAKMTSRS TPSRKPRTHSLWPISST*RPWSTPSRPWGASLVT STRSRGGQCPRLTSCHPRSRRHPHSRRPSPRCR RSSSSSRCTATELRSGRLGARTAEGCLGFV*MC LLDTKQTKSHTLQCKVDLALQSISRSPASNHYGL SA*L*KGPLAGQSFKLDGAPHHALPRQ*VLGRG RICLPLQNQCSPDTGFGKVKLREKQDFKRQEIS Y*EHKWFIFFFLLELGSYENTDSIHRWQQAAGNI FSSLLDFFASEHIEVKVTCILFELGVESVLIQL WAETMRRAEPHLILQPSRSSRSSCARGHVRSLT PAQNAS**YP*IDFQ*SFFPFFFLTLFQTYIMCS RLLWPILCFSFMLT**SHVHCRTICPCPPFTAA QMQRVARLCVRSEPPCCPQGLLRVVSGFSAIQM YPFWLKPSQNPEWKKRGKSHIFLLFKLQFQRLVY FMTSFL*KY*MSLALYNGKV*VFLKHRENAISC QVVMKAERLVH**KH*LPLKLNVR*TARSACAG TRAVTSVYQFRGQGPGLGEAPSPPAAHDKKH*EV WGEVCS*LSWYSVCGHSERTNLP*GVLLCQLSQ ILHSLGVHLEETLAWLSN*SGAVLMLPAEQRMI VFFKTQLSQHFTPNSRLLRTGLEFVLCNICLHEL RNVHPQAACRRVCGAHLLTLPTITRA*LSPLS* MNSGRSFDF*FMRIILCYLCI*LTVLYIVVSSN EFGLGVILSPFSRYKCSRHPWNQQETRAPKIYF* KSVSISFCLCRI*RANDLAETPNGLWAHDETPT SIDLLFLFPIK*RPWKSQFYFFKEVVLVPRVRP HQMLLKNLI*IVWYIPLFISIHRHLLLLVISENS KEKSNSQVFCKHTWS**GHCLRQNGLS*SNCYK FASKKLDSKIQQPCTTQAEESSPIRSSAY*SS* QEVFRFLTDPRCTDVFIKEDIRSSHCGHQALWTH LSGEFVLDPWLRAAVDSSAIHWCESCGEATGTA APRESWSVG*EGARASGML*RVTCSQENVLCQV PPRCVRHGTALEGPAWKADLLYLYRSHLWHPKAE GSWLPH*RRRLGLSHWIVKGIKTVWRCWLYFLS HQVV**RIKGAVTRVF

Frame 2

LPRPRRPRPAVPPAGPPAAPGSRLRPPRPPADY KSRHAPPPPPGFRCCAVSGADRNPESGSDPALH IPKAAARRPGPAAMPTVLCYIRRLRAPLAIGVK TRLDFPEPLRDRPARRPPAGVFAAPARGPAAPAA GRRRRRGPRGCRYPPPSGTAHAGRTGGSLDPQP RV*RS*VLVPDWEPEGQ*AALGNISRE*GVRH* ATEPCECRPATQSCPTSWTLCTKLFLGEPGKSAP SPGEDCERRRNWGRQGRMRL*N*VTLARAARDT FEREYTQVQ*L*VSI*VLHGLLFTLQAAGDERG GGRVESAFKKCQHAHFPKPLSNGHQRSRLQEGHA GVRDG*RWERRDHVHLV*RLQPVPRLRMSRAGP SGHGQRLLCVKQGKVLACQRTRAHPGGAGDAGL *GQGQG*PTAASRSSPCRPGEAAQWAAAALPFHP HLGEAVPPGGPGQVIPSSQLGDQTTGRWSRGGV RHHSARQADTVRSL*VQEGRQMGKGVCISPEGV PEGRAPRVLRHLQRG*LQLDDAGAASGGGRAPEP DGLPARQRRVLHHLQRHPPGYRAARVVCGLLCQ EDGQAHAEAGRLWRPRCRHPRKQRPRGVGAQPV GV*SVFCHLPGAAAPQ*TSVGPLRTSQKPSSRQP KRGSSSREGAGHTPGGTPCSARERECCHQRTEE KASKGEKTQSVQS*AASSHRGRQGTHRASGRDH YRGPSG*ACECNAR*ADHGAGSGEAGHHHH*HQL GSKVHPSSE*HHHAQEELNSLKQTRHPAQAHQT ARGAQAGLPVQYLQQDLPEQQQPEQARALAW*Q AV*VRRVCKIVQPQREPKAARFLQAQQERGGRRV QVPLRHL*EDLPHRERAGVPQLQDR*QDVPM*D VFQILLHQQQPLQAQEEARRQEVCL*GLQQDVL PQGRHAGPPAPAPGRSAASEARGPGGRWGEPGPL QEGAFRVPGVWQGVLLPEQYEQAPAHPRRQEVH LRDLRAQVLPRGCAQGPHPCPLQGHRVDG*PPE GRVYRQDRDLLGRKR*QF*RERRLGASQVQLQAV PAHLRPGEGVPEAHHGGAQGEGLWLQHLQPALC TEGHLPRPHGHPP*KPAGPQRAEVHPPLRDLRA DLQQHREPGAPQAHPHRCEEPRLRAVWEVLCQEG HAEGAHACARQCPRVPVCRVWERHEDQARAAPP HEAAQGHQGVRVQGVPPQVRAEGQHAQALQAAH GD*RFHV*IVWEDIQREEHHGDPQAHPHSGQAVD VLRVRQEVRDRVHAAEARSAHTRQGGGAELPAV RDQGVHQGLHEPTHAAQAPRGARGEDR*PGPPP GDHHHRRLLHWHRPA*ADSGAGGFGRREARESCQ AKSQEKAEARRGGGCSGARGRHLQRILRERDGV HRQCRRRDQFRSTEHSAGSGDPG*PKCDHTIEL SRLNQHHRDPHHHCGRDSVYQSPAGGRGAPYHP* TPVTAGQLNPDRDL*YRQRLCHVAQPPK*RPDP PPAGSLEPTVCGPFHQPDDPGQLHHAPGEPA** PAPAHVAGSAPD*RLATLAAAGTPTAGGPAPGAG GAAAAADVQLLSCVPGDSGQELQRDVWDLFRCV CWIPNKQKVIHCNVRLT*LCRVSPDPPPATITV CQLNSRRDLWQARVLNWMGLHTMPYQGSKSWAGA ASASPYRTSVRPTQGSGK*S*ERSRILRGRR*V IRNTNGSFSFFF*SSVPMRTQTVFTGGSRQQGT FSPHFWIFLQAST*KLK*RVFSLN*EWSRFLYNY GLKP*GVLSRT*SCNLRGHHGHHVQGVT*GH*L QLKTHLSNIHESISNRVFFLFFF*LYFKHTLCV QDCYGQYCVLVLC*HDKVMCTVGPSVPVHPSQLP RCRGSRGCV*GVSLPAAPRGSSGLSQDSLQSKC IHSG*SPARIPSGRNGGKVIFSFCLNFNSKGWC IS*PVFYKNIE*VWLFTMEKCRYF*NTEKMLFPA RW**KQRG*FTNRSINCP*N*MCGEQPGLRVRG HVLSRLCTSFGGRGQGWGRHPALLLPTTRNTER CGEKFALNFPGTLFVATVRGQTCLKVSCFASYPR SCTHWESILRKHWHG*VIDQEQS*CCQQNKG*L CFSKRNFLSTSLQTADF*GQGWNLFCAIYAFMN *GMFIPRQHAGGSVGLTSSPYPPSLAPSSHLSVE *IVGDHLTFNL*ELFYVIYVYN*LFYT**SHQM NSGLG*YCLHSPDTSAPGIHGISRRPGLLRYIF KNQYRFLFAFAESKGQMTSQRLPTGFGLMTKHPL ALIFYSSSL*NKGLGNHNFIFLKKLF*CLE*DR IKCC*RT*FRLCGIYHCLSQYTDTSYFLL*VRT LKKNQTPKFSVNIRGLNRVTV*GKMGCLKAIATN LHQRN*IAKYNNHVPPRQKSPHLYAVLHIDHHD RKYFVF*LIPGAQMYS*RKTLDPAIVATRLCGP ISVENSFWTRGSVQLWTRVPSTGVSLAGRPQVQL LPVNPGLWVEKGLGPLECSSV*RVLRKTFCAKC RLAVSGMGLRWRVRRGRQTSCTSIVPICGIQRR KAHGFPTRGGVLGFPIGL*KALRLFGDVGCISCH IRLYDDE*KVL*PVFS