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Sequence NM_001018064
AAGACGGATTCTCAGACAAGGCTTGCAAATGCCCCGCAGCCATCATTTAACTGCACCCGCAGAATAGTTACGGTTTGTCACCCGACCCTCCCGGATCGCCTAATTTGTCCCTAGTGAGACCCCGAGGCTCTGCCCGCGCCTGGCTTCTTCGTAGCTGGATGCATATCGTGCTCCGGGCAGCGCGGGCGCAGGGCACGCGT
TCGCGCACACCCTAGCACACATGAACACGCGCAAGAGCTGAACCAAGCACGGTTTCCATTTCAAAAAGGGAGACAGCCTCTACCGCGATTGTAGAAGAGA
CTGTGGTGTGAATTAGGGACCGGGAGGCGTCGAACGGAGGAACGGTTCATCTTAGAGACTAATTTTCTGGAGTTTCTGCCCCTGCTCTGCGTCAGCCCTC
ACGTCACTTCGCCAGCAGTAGCAGAGGCGGCGGCGGCGGCTCCCGGAATTGGGTTGGAGCAGGAGCCTCGCTGGCTGCTTCGCTCGCGCTCTACGCGCTC
AGTCCCCGGCGGTAGCAGGAGCCTGGACCCAGGCGCCGCCGGCGGGCGTGAGGCGCCGGAGCCCGGCCTCGAGGTGCATACCGGACCCCCATTCGCATCT
AACAAGGAATCTGCGCCCCAGAGAGTCCCGGGAGCGCCGCCGGTCGGTGCCCGGCGCGCCGGGCCATGCAGCGACGGCCGCCGCGGAGCTCCGAGCAGCG
GTAGCGCCCCCCTGTAAAGCGGTTCGCTATGCCGGGGCCACTGTGAACCCTGCCGCCTGCCGGAACACTCTTCGCTCCGGACCAGCTCAGCCTCTGATAA
GCTGGACTCGGCACGCCCGCAACAAGCACCGAGGAGTTAAGAGAGCCGCAAGCGCAGGGAAGGCCTCCCCGCACGGGTGGGGGAAAGCGGCCGGTGCAGC
GCGGGGACAGGCACTCGGGCTGGCACTGGCTGCTAGGGATGTCGTCCTGGATAAGGTGGCATGGACCCGCCATGGCGCGGCTCTGGGGCTTCTGCTGGCT
GGTTGTGGGCTTCTGGAGGGCCGCTTTCGCCTGTCCCACGTCCTGCAAATGCAGTGCCTCTCGGATCTGGTGCAGCGACCCTTCTCCTGGCATCGTGGCA
TTTCCGAGATTGGAGCCTAACAGTGTAGATCCTGAGAACATCACCGAAATTTTCATCGCAAACCAGAAAAGGTTAGAAATCATCAACGAAGATGATGTTG
AAGCTTATGTGGGACTGAGAAATCTGACAATTGTGGATTCTGGATTAAAATTTGTGGCTCATAAAGCATTTCTGAAAAACAGCAACCTGCAGCACATCAA
TTTTACCCGAAACAAACTGACGAGTTTGTCTAGGAAACATTTCCGTCACCTTGACTTGTCTGAACTGATCCTGGTGGGCAATCCATTTACATGCTCCTGT
GACATTATGTGGATCAAGACTCTCCAAGAGGCTAAATCCAGTCCAGACACTCAGGATTTGTACTGCCTGAATGAAAGCAGCAAGAATATTCCCCTGGCAA
ACCTGCAGATACCCAATTGTGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGC
AGGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGGATAACTAAC
ATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTCACTGTGCATTTTGCACCAA
CTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCCAAACCAGCGCTTCAGTGGTTCTATAACGG
GGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAGTACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATG
AACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAGAAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTG
CAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGAACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGA
CGTCACTGATAAAACCGGTCGGGAACATCTCTCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTT
AAGTTGGCAAGACACTCCAAGTTTGGCATGAAAGGCCCAGCCTCCGTTATCAGCAATGATGATGACTCTGCCAGCCCACTCCATCACATCTCCAATGGGA
GTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAATGACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAA
CAGTCAGCTCAAGCCAGACACATTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTA
GCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTG
AGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAA
GCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTG
CATATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACT
TGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCC
TCCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGG
TACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGG
GGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCTGGACATTCT
AGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCT
GCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTT
TTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACG
ATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACAC
TCCAGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACT
TCTGCTGTACAGATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAA
AAAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAG
ACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTC
TGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGCTTCCGTGAG
ACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGT
CAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCG
GAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTG
CATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATAC
AATTAGGGGAAGCTAATGGAGTTTATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAA
TCCTCATCCACGTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCA
GTGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACT
CCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATAGTCATTGGT
TTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAAAATATTTCTGTTCCTCAAGAAAACTTG
CTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCA
TATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATT
CTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAA
GTTATATGCTGGCCTATGAGAGATGAGAGTTGGGTCGTTTGTTCTCTTTGTTGATGATTT
- refseq_NTRK2.F2 (forward primer)
- refseq_NTRK2.R2 (reverse primer)
- Single exon skipping
Frame 0
KTDSQTRLANAPQPSFNCTRRIVTVCHPTLPDRLICP**DPEALPAPGFFVAGCISCSGQRGRRARV
RAHPSTHEHAQELNQARFPFQKGRQPLPRL*KR
LWCELGTGRRRTEERFILETNFLEFLPLLCVSP
HVTSPAVAEAAAAAPGIGLEQEPRWLLRSRSTRS
VPGGSRSLDPGAAGGREAPEPGLEVHTGPPFAS
NKESAPQRVPGAPPVGARRAGPCSDGRRGAPSS
GSAPL*SGSLCRGHCEPCRLPEHSSLRTSSASDK
LDSARPQQAPRS*ESRKRREGLPARVGESGRCS
AGTGTRAGTGC*GCRPG*GGMDPPWRGSGASAG
WLWASGGPLSPVPRPANAVPLGSGAATLLLASWH
FRDWSLTV*ILRTSPKFSSQTRKG*KSSTKMML
KLMWD*EI*QLWILD*NLWLIKHF*KTATCSTS
ILPETN*RVCLGNISVTLTCLN*SWWAIHLHAPV
TLCGSRLSKRLNPVQTLRICTA*MKAARIFPWQ
TCRYPIVVCHLQIWPHLTSLWRKESLSHYPVVW
QVIRFLICIGMLVTWFPNI*MKQATHRAP*G*LT
FHPMTVGSRSLVWRKIL*EKIKILSTSLCILHQ
LSHFSNLQPQTTTGAFHSL*KATPNQRFSGSIT
GQY*MSPNTSVLKYMLPITRSTTAASSWIIPLT*
TMGTTL**PRMSMGRMRNRFLLTSWAGLELTMV
QTQIILM*FMKIMELQRMTSGTPRTEVMKSLPQ
TSLIKPVGNISRSMLWW*LRLWWDFAFW*CCFCL
SWQDTPSLA*KAQPPLSAMMMTLPAHSITSPMG
VTLHLLRKVAQMLSLLE*PRSLSLKIPSTLASP
TVSSSQTHLFSTSSDITLF*KGS*AKEPLEKCS*
LNAITSVLSRTRSWWQ*RP*RMPVTMHARTSTV
RPSS*PTSSMSTSSSSMASAWRATPSSWSLST*
SMGTSTSSSGHTALMPC*WLRATRPRN*RSRRCC
I*PSRSPRAWSTWRPSTSCTAIWPPGTAWSGRT
CW*KSGTLGCPGTCTALTTTGSVATQCCPFAGC
LQRASCTGNSRRKATSGAWGSCCGRFSPMANSPG
TSCQTMR**SVSLRAESCSDPARAPRRCMS*CW
GAGSESPT*GRTSRASIPSFRTWPRHLRSTWTF
*ARALFPRPILPNVLLRRAERMNIF*LPLEATKL
LSFTLTVLTSKTPRSSRGKQCVLLHP*TQY*LL
FGIISFSLSISLGCSFFFF*IFFFFFFSSSLLH
DSYPFF*INLASALLLTLHRQRP*QT*FVISADT
PVCPPQLTMPCCIPAFDVDEKKGKQIFHLNFVT
SAVQISRVSMDSLLFIYYYYCSYCFWMA*ACV*
KRKLVFNL*SLYLWEIKTREKEDLL*TAIWEEQR
QPLGSAGVSPYLGNTQQLLAGKNVFGTFP*GPF
*GVKRLLASVPWMILFPSPEMIACSREQRWLP*
DTRWRIVCSDTVLSS*VVMIALVCFSSAIHRTFV
NFS*KEVDSCPELISGSGGKAKNLEKIRQAINS
EASFFYNELFRSHFPPTPNFHAHPSF*LCKQNC
AWSSSINTLCADTTAPDVVSLIGRADP*KGMTYT
IRGS*WSLLAEYQCLCVVRW*WVLMNMDPEAWK
SSSTSNPQDCGKGRINP*GKGNLTLRASHALMF
SVHRSSPLLWALVGRVVSFQVYSIVSMLFLFPSL
HSKSQNTKFGTACQREAVPRPSTGSVLLGIVIG
FAKRGLKFK*KFTAI*MVRYTKKEKYFCSSRKL
ATLCEGNFAKLDIFIT*ARLKGSDFHSS*VMLFH
ICF*RCDSSVLGFACAC*LLEHLIFH*RL*KPI
LKNSKVQINRTKGNPVATAVKRGS*QDKPYVHS
SYMLAYER*ELGRLFSLLMI
Frame 1
RRILRQGLQMPRSHHLTAPAE*LRFVTRPSRIA*FVPSETPRLCPRLASS*LDAYRAPGSAGAGHA
FAHTLAHMNTRKS*TKHGFHFKKGDSLYRDCRRD
CGVN*GPGGVERRNGSS*RLIFWSFCPCSASAL
TSLRQQ*QRRRRRLPELGWSRSLAGCFARALRA
QSPAVAGAWTQAPPAGVRRRSPASRCIPDPHSHL
TRNLRPRESRERRRSVPGAPGHAATAAAELRAA
VAPPCKAVRYAGATVNPAACRNTLRSGPAQPLI
SWTRHARNKHRGVKRAASAGKASPHGWGKAAGAA
RGQALGLALAARDVVLDKVAWTRHGAALGLLLA
GCGLLEGRFRLSHVLQMQCLSDLVQRPFSWHRG
ISEIGA*QCRS*EHHRNFHRKPEKVRNHQRR*C*
SLCGTEKSDNCGFWIKICGS*SISEKQQPAAHQ
FYPKQTDEFV*ETFPSP*LV*TDPGGQSIYMLL
*HYVDQDSPRG*IQSRHSGFVLPE*KQQEYSPGK
PADTQLWFAICKSGRT*PHCGGRKVYHIIL*CG
R*SGS*YVLGCW*PGFQTYE*NKPHTGLLKDN*
HFIR*QWEADLLCGGKSCRRRSRFCQPHCAFCTN
YHISRISNLRPPLVHSIHCERQPQTSASVVL*R
GNIE*VQIHLY*NTCYQSHGVPRLPPAG*SHSH
EQWGLHSNSQE*VWEG*ETDFCSLHGLAWN*RWC
KPKLS*CNL*RLWNCSE*HRGHHEQK**NPFHR
RH**NRSGTSLGLCCGGDCVCGGILPFGNAVSA
*VGKTLQVWHERPSLRYQQ***LCQPTPSHLQWE
*HSIFFGRWPRCCHYWNDQDPCH*KSPVLWHHQ
QSAQARHICSAHQAT*HCSEKGARRRSLWKSVP
S*ML*PLS*AGQDLGGSEDPEGCQ*QCTQGLPP*
GRAPDQPPA*AHRQVLWRLRGGRPPHHGL*VHE
AWGPQQVPQGTRP*CRADG*GQPAHGTDAVADA
AYSPADRRGHGLPGVPALRAPRFGHQELPGRGEL
AGENRGLWDVPGRVQH*LLQGRWPHNAAHSLDA
SREHHVQEIHDGKRRLEPGGRVVGDFHLWQTAL
VPAVKQ*GDRVYHSGPSPAATPHVPPGGV*ADAG
VLAARAPHEEEHQGHPYPPSELGQGISGLPGHS
RLGPFSPDRSFPTYSSDGLRG*TSFNCRWRPPS
CSPSL*QY*HQRLREALEGSSVYFFIHRHSIDFF
LALSLSLFPSPLVVPFSFFKFSFSFFFRLPCFT
ILTLSFESIWLLHYY*LCIDKGLNKRNLLYQQT
LQFAHHN*QCLVVFLPLMWMKKRENKYFT*TLSL
LLYRYREFLWIHFYLFIIITVLIVFGWLKPVYK
KENLCSICEAFIYGRLKPERKKIYYEPQYGRNK
DNHWDQLVSVPT*EILSNC*LGRMYSAPSPEDLS
EE*KDYWPLCHG*FFSHHQK**RAVESKDGFRE
TQDGA*CARTQFCLRRL***HWFVSQALSTEPL
STSVEKRWIHVQSSFRGQVGKPRTWKR*DKL*IR
RQVSFTMNFSDLTSLRPLTSMPTRPFNCASKIV
HGLRRLIPCVQTLLLQTSFP**VEQIHKKV*LI
QLGEANGVY*LSINVSALYGGDGF**IWTLKPGN
PHPRRTHRTVGRAESIPKGKETSP*GHHMHSCS
VYTGQVPCSGL*LGEWFHSKCTPLSVCCFCFLH
SIQKVKIQNLAQHANGRLCPDQALEVCF*A*SLV
LQKEGSNLNRNLQLFEWSDIPRKKNISVPQENL
LPSVRGILLNLTSL*HEPD*KGVIFIHLRSCYF
IFVSEGAIALF*VLLAPVNYWNTLFFIKGFESQF
SKIQKCKLTEQKEIQ*QLQSSEGVDKINLTSIQ
VICWPMRDESWVVCSLC**F
Frame 2
DGFSDKACKCPAAII*LHPQNSYGLSPDPPGSPNLSLVRPRGSARAWLLRSWMHIVLRAARAQGTR
SRTP*HT*TRARAEPSTVSISKRETASTAIVEE
TVV*IRDREASNGGTVHLRD*FSGVSAPALRQPS
RHFASSSRGGGGGSRNWVGAGASLAASLALYAL
SPRR*QEPGPRRRRRA*GAGARPRGAYRTPIRI
*QGICAPESPGSAAGRCPARRAMQRRPPRSSEQR
*RPPVKRFAMPGPL*TLPPAGTLFAPDQLSL**
AGLGTPATSTEELREPQAQGRPPRTGGGKRPVQ
RGDRHSGWHWLLGMSSWIRWHGPAMARLWGFCWL
VVGFWRAAFACPTSCKCSASRIWCSDPSPGIVA
FPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHIN
FTRNKLTSLSRKHFRHLDLSELILVGNPFTCSC
DIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLA
NLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITN
ISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP
TITFLESPTSDHHWCIPFTVKGNPKPALQWFYNG
AILNESKYICTKIHVTNHTEYHGCLQLDNPTHM
NNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDG
ANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTD
VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL
KLARHSKFGMKGPASVISNDDDSASPLHHISNG
SNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITN
SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFL
AECYNLCPEQDKILVAVKTLKDASDNARKDFHR
EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMK
HGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML
HIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN
LLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMP
PESIMYRKFTTESDVWSLGVVLWEIFTYGKQPW
YQLSNNEVIECITQGRVLQRPRTCPQEVYELML
GCWQREPHMRKNIKGIHTLLQNLAKASPVYLDIL
G*GPFPQTDPSQRTPQTG*EDEHLLTAAGGHQA
ALLHSDSINIKDSEKLSREAVCTSSSIDTVLTS
FWHYLFLSFHLPWLFLFLFLNFLFLFFFVFPASR
FLPFLLNQSGFCITINSA*TKALTNVICYISRH
SSLPTTTNNALLYSCL*CG*KKGKTNISLKLCH
FCCTDIESFYGFTSIYLLLLLFLLFLDGLSLCIK
KKTCVQSVKPLSMGD*NQRERRFIMNRNMGGTK
TTTGISWCQSLLRKYSATVSWEECIRHLPLRTF
LRSKKTTGLCAMDDSFPITRNDSVQ*RAKMASVR
HKMAHSVLGHSFVFVGCDDSTGLFLKRYPQNLC
QLQLKRGGFMSRAHFGVRWESQELGKDKTSYKF
GGKFLLQ*TFQISLPSDP*LPCPPVLLTVQAKLC
MVFVD*YLVCRHYCSRRRFPDR*SRSIKRYDLY
N*GKLMEFIS*VSMSLRCTVVMGFNEYGP*SLE
ILIHVEPTGLWEGQNQSLRERKPHPEGITCTHVQ
CTQVKSLALGSSWESGFIPSVLHCQYAVFVSFT
PFKKSKYKIWHSMPTGGCAQTKHWKCASRHSHW
FCKKRAQI*IEIYSYLNGQIYQERKIFLFLKKTC
YPL*GEFC*T*HLYNMSQIERE*FSFILGHVIS
YLFLKVR*LCFRFCLRLLITGTPYFSLKALKAN
SQKFKSAN*QNKRKSSSNCSQARELTR*TLRPFK
LYAGL*EMRVGSFVLFVDD
Sequence NM_001018066
AAGACGGATTCTCAGACAAGGCTTGCAAATGCCCCGCAGCCATCATTTAACTGCACCCGCAGAATAGTTACGGTTTGTCACCCGACCCTCCCGGATCGCCTAATTTGTCCCTAGTGAGACCCCGAGGCTCTGCCCGCGCCTGGCTTCTTCGTAGCTGGATGCATATCGTGCTCCGGGCAGCGCGGGCGCAGGGCACGCGT
TCGCGCACACCCTAGCACACATGAACACGCGCAAGAGCTGAACCAAGCACGGTTTCCATTTCAAAAAGGGAGACAGCCTCTACCGCGATTGTAGAAGAGA
CTGTGGTGTGAATTAGGGACCGGGAGGCGTCGAACGGAGGAACGGTTCATCTTAGAGACTAATTTTCTGGAGTTTCTGCCCCTGCTCTGCGTCAGCCCTC
ACGTCACTTCGCCAGCAGTAGCAGAGGCGGCGGCGGCGGCTCCCGGAATTGGGTTGGAGCAGGAGCCTCGCTGGCTGCTTCGCTCGCGCTCTACGCGCTC
AGTCCCCGGCGGTAGCAGGAGCCTGGACCCAGGCGCCGCCGGCGGGCGTGAGGCGCCGGAGCCCGGCCTCGAGGTGCATACCGGACCCCCATTCGCATCT
AACAAGGAATCTGCGCCCCAGAGAGTCCCGGGAGCGCCGCCGGTCGGTGCCCGGCGCGCCGGGCCATGCAGCGACGGCCGCCGCGGAGCTCCGAGCAGCG
GTAGCGCCCCCCTGTAAAGCGGTTCGCTATGCCGGGGCCACTGTGAACCCTGCCGCCTGCCGGAACACTCTTCGCTCCGGACCAGCTCAGCCTCTGATAA
GCTGGACTCGGCACGCCCGCAACAAGCACCGAGGAGTTAAGAGAGCCGCAAGCGCAGGGAAGGCCTCCCCGCACGGGTGGGGGAAAGCGGCCGGTGCAGC
GCGGGGACAGGCACTCGGGCTGGCACTGGCTGCTAGGGATGTCGTCCTGGATAAGGTGGCATGGACCCGCCATGGCGCGGCTCTGGGGCTTCTGCTGGCT
GGTTGTGGGCTTCTGGAGGGCCGCTTTCGCCTGTCCCACGTCCTGCAAATGCAGTGCCTCTCGGATCTGGTGCAGCGACCCTTCTCCTGGCATCGTGGCA
TTTCCGAGATTGGAGCCTAACAGTGTAGATCCTGAGAACATCACCGAAATTTTCATCGCAAACCAGAAAAGGTTAGAAATCATCAACGAAGATGATGTTG
AAGCTTATGTGGGACTGAGAAATCTGACAATTGTGGATTCTGGATTAAAATTTGTGGCTCATAAAGCATTTCTGAAAAACAGCAACCTGCAGCACATCAA
TTTTACCCGAAACAAACTGACGAGTTTGTCTAGGAAACATTTCCGTCACCTTGACTTGTCTGAACTGATCCTGGTGGGCAATCCATTTACATGCTCCTGT
GACATTATGTGGATCAAGACTCTCCAAGAGGCTAAATCCAGTCCAGACACTCAGGATTTGTACTGCCTGAATGAAAGCAGCAAGAATATTCCCCTGGCAA
ACCTGCAGATACCCAATTGTGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGC
AGGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGGATAACTAAC
ATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTCACTGTGCATTTTGCACCAA
CTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCCAAACCAGCGCTTCAGTGGTTCTATAACGG
GGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAGTACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATG
AACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAGAAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTG
CAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGAACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGA
CGTCACTGATAAAACCGGTCGGGAACATCTCTCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTT
AAGTTGGCAAGACACTCCAAGTTTGGCATGAAAGGCCCAGCCTCCGTTATCAGCAATGATGATGACTCTGCCAGCCCACTCCATCACATCTCCAATGGGA
GTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAATGACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAA
CAGTCAGCTCAAGCCAGACACATGGCCCAGAGGTTCCCCCAAGACCGCCTGATAATAATTTGGTATTTGGAGGCTCCTGTGTCACTGCAGGAACTAAAGG
AGGCTAAATCCATGCCTGATGGAGGAGAAGAGTTCTATGGTTATCTGCAAATTCTGGCCAGACAACATCTTGACGTCACTCCTTAGCTTCCATAACCTAG
CCAAGCAAGAAGTTGCCTTTCCAAGACAAAGCAGTGTGCTCTAATGACTAACCCCTCAAAGTACTATGCCACTTTAACTATAGACCCATCTCCTCGATCA
ATCAGGATGGCAAGATGGAGCTGAGGAGCTCAGCAACATCAAGTCTGGAGTTGGTCTTTAACTCAACTAGCTCGTTTAGACGTGTCTGAACACCACATCA
CCTGACAGCACGGGGTGGTTTCCCAGTAAAATTTACAAACTCAGCTCAAGGGCAGCTGTGTTGCTTTCCTTTCCTTGACTGCTGAGAAACTTTTTGACAG
GGAACAATGGAAACACACCTTCTGAGCTGAAACAAACAAACAGAAACAAAACATACTAACCAGCAAAATCCCCAAATCATCAATCTTGGGTTCTCTTGAA
GGGCAGGAGTGTGTTTTATCTTCTCCCGTCGGAGCAAACACTATAGATGTCCTCCCTAAAATTCTGTCTTCCCTAGAGCAGCCTTGTAAATTAGCTAGGG
TCCTAGGGTTGAGGCCTAAATCAACTTAAAATTGTCTCTAAATATGTACCTGGATGTGTTTGTACTTGCAGAGCATGCCCTCTTCATGTGCCTAGGGCTA
GTAACTCCCTGTGGCAGAGGCATGTAAAGTATTCTGACTTTTTTTTTTTCAACTTAATTCCATTTCCAATGAAATGGATTTTTAAAAATTTTCTCCAGAG
TGTGCCATACTTCTCCAGCTATTATAGTTAATGTGTGTGTATCCTTGTGTATATGTGTGTTTGTGTGTGCATATGTGTTTTCCTAGTGGTTACATGCTTA
CTAGGCAATTATGTAAATAAGCACAGATTCATAGGCCAGCTAGGCCTGAGGAAAGAAGACATTATAAAGGGAGGGAGTATTTTAACATTAGCTAAAGCTA
TCACACAAGGCACCCATTCTGCTCCCCTCAACAGCCACAGCCCACTTCGTCCTTGTCTTACCAATAAGGGGAAAGGCTGGAGGTGATATTTTTCACAGAA
CCGCAGAGGTTTTGAACATATTTGCAACATTACTTTGAGTACACATGAGCAAAAATTCTGAATTACATCCAGGACCCCAGAAGCTCATTAGATCAAAGAG
TGCGGGGCCCCTCAGAGTTACCAGAGATTATCTGCAGACTTCAGTGCAATCGAATGACCATGGTCCATTTTGATGGTCAGAGGTAGGACTGAAAAACGGG
TAGAAACAATTGCTTTAGCGCTTCCTTCTGTACTTTGCCTATTAATGTTTTGTCTTTCAAAAATATATTTTCTCCTAATTGTTTAATTGGCCAAATAATG
GCTGCTTTGGGAGTTGTTTGTATGCCTTGGAAGGCCATGGCCTGCACTTTAAAAATAAGCTAAGTCCATTCTGCCCAGCACGAGCATTAGGACAGAGAAT
GCACTTATTTTAGGATCCTTAAAAATTGCTTCTTTTATGGCACACTGGGTTGACGACTCATCTCGTGGGAGCCTTCATGGCACATTGCTGCTGTTCTGCA
GGTCCCAATACAATTCCTTCCCCCTCTCAGTGCCACGGCCCCCCCATTGCTAGCTACAACAATTTGATATCATATTCCCTTTTCAACTCCAAAGGAGATG
ATAAGAAGCTATCAAATAATGCTTTAAAAAAGCAACTTGAGTTTCTTAAAAGAAAGGAAATGAATACATGCTGCATAATTACATTTAAAATGTAAGCCAT
GTTATTATAAGCCGCACTGAGATGAAGATTTGTTAGCAAACCAGTTTCAAGCACACTCACAGTGAAGTAAAATCATGTTTTTAGCATCTGACCATTGGGT
AATATTATTCTTTGTTATCAAAAGAGAAATATCACCCAAGTATAGTATACTTAGACCTCCTAGAGGAAACACTCCAGTCCTAAGCTTGGTGTCTGAAAAG
AAAAACAAAAATAAAGATTATGGATTTAGGTCAGGGAGACAGAGTGATATTCTGAAGACTGTGTTTACTCCCTCATCATCGGCCAACCAAGATGGAGTTC
TGCATCCTGCACATATCAGACATTTCAGTCCAATTTCACCAAAGCATCAGTGATGTTCTAGAAGCATCCCAGCAGATGGAGGATCCTAATGTATTTGTTC
TGGGTATTTCCCAAGGCCCAGCCTGACTGGAGTGTGTGTACCAACAGGATGAATCCAATCAAGCTACGCCCCCATTTTGGTTTCGGATTGGCCACTCTTG
CATGTGCTAGTAGATTGTGGACCAGGACCAGCTGAGCAAACACAGTTGCAGAGTAGCCTCCTATGTTGCTAAGAAGCTCCTGCTACCCAGGTGCTTTGAA
CAATTGAGTGCTCCCTCTGGTTAAGTAGAGATGGCACCACCGGAGTTTTTCTTGGATGTGAGGCTCAATCCTTTACGGCAGCTATTATAACAAAGTGAAG
GTTTTCTCCCTGGGAAATGCAGCTTTTCTCTGTCTTTACTAATTCTGCCAGCCTGTGAGAGTAACCACCGTAGCTGGGCTTCTTCTCAGATTAATTGTCA
TGCCAGGTCTCCTTCCTGGGGAGCTGTGATGCTGCTCTGAGGTTGATTGCTGAGGTTGTAGTGGGTTTTTGTTTGTTTTTGTTTAGTTTTTCTTGATTGT
TCTTCTTTCTCTTGAATGGCAAGAGAAGAAACACTTTCTCTAACCCACGGCCAGGAAGGAAATGGGGAGAGAGCTACTTCTTAGTTCAACCTGGTTGCCA
CATAAAGGAATCTCTCTCCTTGGACTCAGCCCCTAACTGGAAGCAAGAGCCACTGCCCTCTGAGACTGAGAGAGCAGCCCGAGGAGGAGATGAATCCATT
CTGCCCTTTGTTTGGGTTTGCTTCCTGTCAGTGAGAGAATGCTGAGGCAGTTCCTGTTATGTGAAACTTTCATTTTTAAAACCAGGACAGTCCTAAACAG
ACTGGAATGAGTTGGTCAATCCCAGTTGGTATAGGCCCAATGATTTTTGCTAGTAAGATAGGATTGTCTTCCTCACCCAAAATGCCTTCAAGTGCCCTAA
AATGGGTATTTTAAAATAAGAATAAATAATGTAGATTTAGTAGAAAACCTGGAAAACATAAGAAACAAAGATGAAACGAAAAGTCCCATGTAATTCCACC
AGTTAGAGTTAACCACTGATATCGTTTGGATATATGGCTTTCTAGTCTTGTGGATATCCTTTTAATCTCTTGTAATATAAAGTCTGACCATATGTGTCCT
TGCATTTGTTTGTACTGGACTCTGTTAATATTTCTATAGTAATGGCTCACTTTGGGGAGATTGTGCTGCACAGTGTGTAGGAAGCACATTGGGTGTATTA
TTCCCAGTTTTGTATTTTGTATTTCCTTGGAGATGTGCAGGGGTTAAGAGCGGGGGTCTGGCCATAGCTGGCCACGTCAGACTCTCATATGGTAAGTATC
ACAGAGCACATGAGGCCTGTGTTATGCGCTGGAAAGACTCAGGAAATGAGAGGCTCTCTTGTTCTGACAAGGCAGGCTGAGAGCTCTCATTTAGGGTCAT
CACTCCAGATAACTCCAAATGCAGTTTATTGCTCAACTGAAGCAGATGATCACTTTTTGCCTCCAAGTTCTTCACCCTAGCTAGCTCCTTTCAAAGAGCC
GAGTATGCTGGATCTTAAAGGGCCAAACTAGTTACATCTCATACATTTCCTGATGTTTAGGGATGCCTTCACTTCCATCAAGGATACCTTGGCTGTGCAA
GGACCTCTGATAGCTGGAGTCTCCTTTTGGTCACTCCCAGCTTTGCTTAAACTTGATGGAGTTTGCTGTCCAGTGATCCCCGGATCTTTCATCATGAAAG
CCTTCCTTCCTCTCCTGATGTCTCAGGCCTCTAGACCTAGACTGGGGTTCTGGCAAGGAGGCCTCTATCAATAGTATGACATCCAATAATATGTTAGTGT
TGATATTTTGCACAGTAATATTAAGTTTAAGAGATTATAAAAATGAGTTCAAATGAATAAGTTCCTGTGATGTAAGAGATTAGATATGTGTGATTTCAGA
ACCAAAGGCAGGGGGGAATCCCAGAAAGAAAACAATAATATAATCCTAGTTTCTATATATTATTTTTATTCATTACTGTATATGGGTAGAGATCAATATT
CTTTCTTATGCTGTTACTATTAATTAACACATTTTTTAACCATGCCATTGAACTTTTGGGTGCATTAAAGTGGAACCCAAGCTCCTCATTAGATAATAAT
GGCATTTGGACTGAGTGCCATATTCCTAAATTTCCAATAAAGTGGTTGATATAGAGAGGACAGGATAAAGCCCTATAGTGTGCAGTTATATCAAAACAGC
TAGTCTCCACTTTAGGGAATGCCTTTACTAGAGATTACATGAAATGTCTGCTTATAAAATAAGCAGAGATGGCACCACTAAGCAGCCACCTGAATTGTTT
TCCTACAGGAATGATTACTTTTCAGATCCATTTATGTTTTCATGCTCAATACTTACTCCCCTTCCCTGCAACACCCAAAGAGTTTACTTTTGCAAGTCAT
TTGGTCTTCAGTCTACTACTGAGGAATAGAGAGGCACTAACTGCTTTACCCAGGATCAGAACTCATGTTCTTACCTTCTATTAATAGAGTACTTGAGCCA
GATGGACTAACTGGTCTCACATTTTCTCTATCTTGGTTTTACTTCCATAAACATCAATATCTTTACCCACATGATTTTTCCATCCTCCCATTTTTTTCCA
TATGTATTAGGGTTCAGGAACTATGATGCTAATGATCACATTTCTTCCTAGTTCCTAATTTCATTAGTGCCATTTCCTGATATCTACAGAAACAATTATC
AATACATGTAGCTGCTTGAGCCTTATTTAGAAGGCTAGCCTTTCTTTTCCAAGTGCTGTCAGAATGTATACATTTAGTCTGTCTTTTTCCCTTTTAGGAG
TCTTTGTTCTGGGTTGATGGCAAAATTCCTCTTTTTACATGTGAGATTTTTGATTTCACTGAATTCTACCTAGATTTTTATGGACATTGGATTTTAAAGA
GGAAAACACTCATTTTCTTAGTAAGATATTGGTGATACATAGCTATGCCATTGATTTCCATACTCCTGAGCTTTGGGGAGGGAGACAGTGGCCAAGTAGC
AGGCAGAATAAGATCATCACTCATGTCCTGAATCAATCACACTTTCCTTCTCGGATTGTGTATATGCTCTGCCACTTCCTACATATTACATCCTGAGTTT
TTAAGTAAAGTGGATCTTAGCCAGATTTGAGTCTAATGGCTGATTCATCGGCATAGTTCTTGGCGTTAACATCTCAGTGTCCTCTTTAGTTCTCTTTGAG
GATTCATGTCATTGAGGGCCTTTGTGCCTCCACTTGTCTCAGTATGAGGAAGAACTTTGGTGTGAGGGCGGAGCTATGTGAAGGGTTGCTGGGTTGGGGG
ATTAGTTCATATGGTCCCCATGCCATCTATTTACTTTTGGAGAGAGGGGACTTTGAGTGGGTGGGTATGGATAGATGTTCCTCAAGGAAACCCTGCTGGC
TAATGGGCACTACATCTGTGTATTACTGTGATTCTCTCTGTAAGCTCCCCATGTGGCCAAGGACCCCCCTCCTACCAGGGCACTTCCTGCCACCTCATTG
CACTGGTCTCAACCATTCAGCCTGCTGCTGCTGCACCATGTTGGGCTGCGGTAGGATAGGGAAGGGGTTCTGTTGATTGCTAAATGTTGCCTAACTTTAT
TTCCCTCTCCCACATTTCATGCAAGGGAGCGGACCTAACACATGACTTGCATTCTCTTCCTATGTTCAGAAACTCCAGGGCTTGCCCACGTGTATGTATG
AGTGACCAATGGAGCTTGGAATTCTTTATCTATATGATCTGTCCGAAAATGAGATCTTTTGTACTGGAATTTGTGATGTAGTTGATCATTCAGAGCCAAA
CGCATATACCAATAAAGACAAGACTGTCATATA
- refseq_NTRK2.F2 (forward primer)
- refseq_NTRK2.R2 (reverse primer)
- Single exon skipping
Frame 0
KTDSQTRLANAPQPSFNCTRRIVTVCHPTLPDRLICP**DPEALPAPGFFVAGCISCSGQRGRRARV
RAHPSTHEHAQELNQARFPFQKGRQPLPRL*KR
LWCELGTGRRRTEERFILETNFLEFLPLLCVSP
HVTSPAVAEAAAAAPGIGLEQEPRWLLRSRSTRS
VPGGSRSLDPGAAGGREAPEPGLEVHTGPPFAS
NKESAPQRVPGAPPVGARRAGPCSDGRRGAPSS
GSAPL*SGSLCRGHCEPCRLPEHSSLRTSSASDK
LDSARPQQAPRS*ESRKRREGLPARVGESGRCS
AGTGTRAGTGC*GCRPG*GGMDPPWRGSGASAG
WLWASGGPLSPVPRPANAVPLGSGAATLLLASWH
FRDWSLTV*ILRTSPKFSSQTRKG*KSSTKMML
KLMWD*EI*QLWILD*NLWLIKHF*KTATCSTS
ILPETN*RVCLGNISVTLTCLN*SWWAIHLHAPV
TLCGSRLSKRLNPVQTLRICTA*MKAARIFPWQ
TCRYPIVVCHLQIWPHLTSLWRKESLSHYPVVW
QVIRFLICIGMLVTWFPNI*MKQATHRAP*G*LT
FHPMTVGSRSLVWRKIL*EKIKILSTSLCILHQ
LSHFSNLQPQTTTGAFHSL*KATPNQRFSGSIT
GQY*MSPNTSVLKYMLPITRSTTAASSWIIPLT*
TMGTTL**PRMSMGRMRNRFLLTSWAGLELTMV
QTQIILM*FMKIMELQRMTSGTPRTEVMKSLPQ
TSLIKPVGNISRSMLWW*LRLWWDFAFW*CCFCL
SWQDTPSLA*KAQPPLSAMMMTLPAHSITSPMG
VTLHLLRKVAQMLSLLE*PRSLSLKIPSTLASP
TVSSSQTHGPEVPPRPPDNNLVFGGSCVTAGTKG
G*IHA*WRRRVLWLSANSGQTTS*RHSLASIT*
PSKKLPFQDKAVCSND*PLKVLCHFNYRPISSI
NQDGKMELRSSATSSLELVFNSTSSFRRV*TPHH
LTARGGFPVKFTNSAQGQLCCFPFLDC*ETF*Q
GTMETHLLS*NKQTETKHTNQQNPQIINLGFS*
RAGVCFIFSRRSKHYRCPP*NSVFPRAAL*IS*G
PRVEA*INLKLSLNMYLDVFVLAEHALFMCLGL
VTPCGRGM*SILTFFFST*FHFQ*NGFLKIFSR
VCHTSPAIIVNVCVSLCICVFVCAYVFS*WLHAY
*AIM*ISTDS*AS*A*GKKTL*REGVF*H*LKL
SHKAPILLPSTATAHFVLVLPIRGKAGGDIFHR
TAEVLNIFATLL*VHMSKNSELHPGPQKLIRSKS
AGPLRVTRDYLQTSVQSNDHGPF*WSEVGLKNG
*KQLL*RFLLYFAY*CFVFQKYIFS*LFNWPNN
GCFGSCLYALEGHGLHFKNKLSPFCPARALGQRM
HLF*DP*KLLLLWHTGLTTHLVGAFMAHCCCSA
GPNTIPSPSQCHGPPIASYNNLISYSLFNSKGD
DKKLSNNALKKQLEFLKRKEMNTCCIITFKM*AM
LL*AALR*RFVSKPVSSTLTVK*NHVFSI*PLG
NIILCYQKRNITQV*YT*TS*RKHSSPKLGV*K
EKQK*RLWI*VRETE*YSEDCVYSLIIGQPRWSS
ASCTYQTFQSNFTKASVMF*KHPSRWRILMYLF
WVFPKAQPDWSVCTNRMNPIKLRPHFGFGLATL
ACASRLWTRTS*ANTVAE*PPMLLRSSCYPGALN
N*VLPLVK*RWHHRSFSWM*GSILYGSYYNKVK
VFSLGNAAFLCLY*FCQPVRVTTVAGLLLRLIV
MPGLLPGEL*CCSEVDC*GCSGFLFVFV*FFLIV
LLSLEWQEKKHFL*PTARKEMGRELLLSSTWLP
HKGISLLGLSP*LEARATAL*D*ESSPRRR*IH
SALCLGLLPVSERMLRQFLLCETFIFKTRTVLNR
LE*VGQSQLV*AQ*FLLVR*DCLPHPKCLQVP*
NGYFKIRINNVDLVENLENIRNKDETKSPM*FH
QLELTTDIVWIYGFLVLWISF*SLVI*SLTICVL
AFVCTGLC*YFYSNGSLWGDCAAQCVGSTLGVL
FPVLYFVFPWRCAGVKSGGLAIAGHVRLSYGKY
HRAHEACVMRWKDSGNERLSCSDKAG*ELSFRVI
TPDNSKCSLLLN*SR*SLFASKFFTLASSFQRA
EYAGS*RAKLVTSHTFPDV*GCLHFHQGYLGCA
RTSDSWSLLLVTPSFA*T*WSLLSSDPRIFHHES
LPSSPDVSGL*T*TGVLARRPLSIV*HPIIC*C
*YFAQ*Y*V*EIIKMSSNE*VPVM*EIRYV*FQ
NQRQGGIPERKQ*YNPSFYILFLFITVYG*RSIF
FLMLLLLINTFFNHAIELLGALKWNPSSSLDNN
GIWTECHIPKFPIKWLI*RGQDKAL*CAVISKQ
LVSTLGNAFTRDYMKCLLIK*AEMAPLSSHLNCF
PTGMITFQIHLCFHAQYLLPFPATPKEFTFASH
LVFSLLLRNREALTALPRIRTHVLTFY**ST*A
RWTNWSHIFSILVLLP*TSISLPT*FFHPPIFFH
MY*GSGTMMLMITFLPSS*FH*CHFLISTETII
NTCSCLSLI*KASLSFPSAVRMYTFSLSFSLLG
VFVLG*WQNSSFYM*DF*FH*ILPRFLWTLDFKE
ENTHFLSKILVIHSYAIDFHTPELWGGRQWPSS
RQNKIITHVLNQSHFPSRIVYMLCHFLHITS*V
FK*SGS*PDLSLMADSSA*FLALTSQCPL*FSLR
IHVIEGLCASTCLSMRKNFGVRAELCEGLLGWG
ISSYGPHAIYLLLERGDFEWVGMDRCSSRKPCW
LMGTTSVYYCDSLCKLPMWPRTPLLPGHFLPPHC
TGLNHSACCCCTMLGCGRIGKGFC*LLNVA*LY
FPLPHFMQGSGPNT*LAFSSYVQKLQGLPTCMY
E*PMELGILYLYDLSENEIFCTGICDVVDHSEPN
AYTNKDKTVI
Frame 1
RRILRQGLQMPRSHHLTAPAE*LRFVTRPSRIA*FVPSETPRLCPRLASS*LDAYRAPGSAGAGHA
FAHTLAHMNTRKS*TKHGFHFKKGDSLYRDCRRD
CGVN*GPGGVERRNGSS*RLIFWSFCPCSASAL
TSLRQQ*QRRRRRLPELGWSRSLAGCFARALRA
QSPAVAGAWTQAPPAGVRRRSPASRCIPDPHSHL
TRNLRPRESRERRRSVPGAPGHAATAAAELRAA
VAPPCKAVRYAGATVNPAACRNTLRSGPAQPLI
SWTRHARNKHRGVKRAASAGKASPHGWGKAAGAA
RGQALGLALAARDVVLDKVAWTRHGAALGLLLA
GCGLLEGRFRLSHVLQMQCLSDLVQRPFSWHRG
ISEIGA*QCRS*EHHRNFHRKPEKVRNHQRR*C*
SLCGTEKSDNCGFWIKICGS*SISEKQQPAAHQ
FYPKQTDEFV*ETFPSP*LV*TDPGGQSIYMLL
*HYVDQDSPRG*IQSRHSGFVLPE*KQQEYSPGK
PADTQLWFAICKSGRT*PHCGGRKVYHIIL*CG
R*SGS*YVLGCW*PGFQTYE*NKPHTGLLKDN*
HFIR*QWEADLLCGGKSCRRRSRFCQPHCAFCTN
YHISRISNLRPPLVHSIHCERQPQTSASVVL*R
GNIE*VQIHLY*NTCYQSHGVPRLPPAG*SHSH
EQWGLHSNSQE*VWEG*ETDFCSLHGLAWN*RWC
KPKLS*CNL*RLWNCSE*HRGHHEQK**NPFHR
RH**NRSGTSLGLCCGGDCVCGGILPFGNAVSA
*VGKTLQVWHERPSLRYQQ***LCQPTPSHLQWE
*HSIFFGRWPRCCHYWNDQDPCH*KSPVLWHHQ
QSAQARHMAQRFPQDRLIIIWYLEAPVSLQELK
EAKSMPDGGEEFYGYLQILARQHLDVTP*LP*PS
QARSCLSKTKQCALMTNPSKYYATLTIDPSPRS
IRMARWS*GAQQHQVWSWSLTQLARLDVSEHHI
T*QHGVVSQ*NLQTQLKGSCVAFLSLTAEKLFDR
EQWKHTF*AETNKQKQNILTSKIPKSSILGSLE
GQECVLSSPVGANTIDVLPKILSSLEQPCKLAR
VLGLRPKST*NCL*ICTWMCLYLQSMPSSCA*G*
*LPVAEACKVF*LFFFQLNSISNEMDF*KFSPE
CAILLQLL*LMCVYPCVYVCLCVHMCFPSGYML
TRQLCK*AQIHRPARPEERRHYKGREYFNIS*SY
HTRHPFCSPQQPQPTSSLSYQ*GERLEVIFFTE
PQRF*TYLQHYFEYT*AKILNYIQDPRSSLDQR
VRGPSELPEIICRLQCNRMTMVHFDGQR*D*KTG
RNNCFSASFCTLPINVLSFKNIFSPNCLIGQIM
AALGVVCMPWKAMACTLKIS*VHSAQHEH*DRE
CTYFRILKNCFFYGTLG*RLISWEPSWHIAAVLQ
VPIQFLPPLSATAPPLLATTI*YHIPFSTPKEM
IRSYQIML*KSNLSFLKERK*IHAA*LHLKCKP
CYYKPH*DEDLLANQFQAHSQ*SKIMFLASDHWV
ILFFVIKREISPKYSILRPPRGNTPVLSLVSEK
KNKNKDYGFRSGRQSDILKTVFTPSSSANQDGV
LHPAHIRHFSPISPKHQ*CSRSIPADGGS*CICS
GYFPRPSLTGVCVPTG*IQSSYAPILVSDWPLL
HVLVDCGPGPAEQTQLQSSLLCC*EAPATQVL*
TIECSLWLSRDGTTGVFLGCEAQSFTAAIITK*R
FSPWEMQLFSVFTNSASL*E*PP*LGFFSD*LS
CQVSFLGSCDAALRLIAEVVVGFCLFLFSFS*L
FFFLLNGKRRNTFSNPRPGRKWGESYFLVQPGCH
IKESLSLDSAPNWKQEPLPSETERAARGGDESI
LPFVWVCFLSVREC*GSSCYVKLSFLKPGQS*T
DWNELVNPSWYRPNDFC**DRIVFLTQNAFKCPK
MGILK*E*IM*I**KTWKT*ETKMKRKVPCNST
S*S*PLISFGYMAF*SCGYPFNLL*YKV*PYVS
LHLFVLDSVNISIVMAHFGEIVLHSV*EAHWVYY
SQFCILYFLGDVQGLRAGVWP*LATSDSHMVSI
TEHMRPVLCAGKTQEMRGSLVLTRQAESSHLGS
SLQITPNAVYCSTEADDHFLPPSSSP*LAPFKEP
SMLDLKGPN*LHLIHFLMFRDAFTSIKDTLAVQ
GPLIAGVSFWSLPALLKLDGVCCPVIPGSFIMK
AFLPLLMSQASRPRLGFWQGGLYQ*YDIQ*YVSV
DILHSNIKFKRL*K*VQMNKFL*CKRLDMCDFR
TKGRGESQKENNNIILVSIYYFYSLLYMGRDQY
SFLCCYY*LTHFLTMPLNFWVH*SGTQAPH*IIM
AFGLSAIFLNFQ*SG*YREDRIKPYSVQLYQNS
*SPL*GMPLLEIT*NVCL*NKQRWHH*AAT*IV
FLQE*LLFRSIYVFMLNTYSPSLQHPKSLLLQVI
WSSVYY*GIERH*LLYPGSELMFLPSINRVLEP
DGLTGLTFSLSWFYFHKHQYLYPHDFSILPFFS
ICIRVQEL*C**SHFFLVPNFISAIS*YLQKQLS
IHVAA*ALFRRLAFLFQVLSECIHLVCLFPF*E
SLFWVDGKIPLFTCEIFDFTEFYLDFYGHWILK
RKTLIFLVRYW*YIAMPLISILLSFGEGDSGQVA
GRIRSSLMS*INHTFLLGLCICSATSYILHPEF
LSKVDLSQI*V*WLIHRHSSWR*HLSVLFSSL*
GFMSLRAFVPPLVSV*GRTLV*GRSYVKGCWVGG
LVHMVPMPSIYFWREGTLSGWVWIDVPQGNPAG
*WALHLCITVILSVSSPCGQGPPSYQGTSCHLI
ALVSTIQPAAAAPCWAAVG*GRGSVDC*MLPNFI
SLSHISCKGADLTHDLHSLPMFRNSRACPRVCM
SDQWSLEFFIYMICPKMRSFVLEFVM*LIIQSQ
THIPIKTRLSY
Frame 2
DGFSDKACKCPAAII*LHPQNSYGLSPDPPGSPNLSLVRPRGSARAWLLRSWMHIVLRAARAQGTR
SRTP*HT*TRARAEPSTVSISKRETASTAIVEE
TVV*IRDREASNGGTVHLRD*FSGVSAPALRQPS
RHFASSSRGGGGGSRNWVGAGASLAASLALYAL
SPRR*QEPGPRRRRRA*GAGARPRGAYRTPIRI
*QGICAPESPGSAAGRCPARRAMQRRPPRSSEQR
*RPPVKRFAMPGPL*TLPPAGTLFAPDQLSL**
AGLGTPATSTEELREPQAQGRPPRTGGGKRPVQ
RGDRHSGWHWLLGMSSWIRWHGPAMARLWGFCWL
VVGFWRAAFACPTSCKCSASRIWCSDPSPGIVA
FPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHIN
FTRNKLTSLSRKHFRHLDLSELILVGNPFTCSC
DIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLA
NLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITN
ISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP
TITFLESPTSDHHWCIPFTVKGNPKPALQWFYNG
AILNESKYICTKIHVTNHTEYHGCLQLDNPTHM
NNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDG
ANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTD
VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL
KLARHSKFGMKGPASVISNDDDSASPLHHISNG
SNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITN
SQLKPDTWPRGSPKTA***FGIWRLLCHCRN*R
RLNPCLMEEKSSMVICKFWPDNILTSLLSFHNL
AKQEVAFPRQSSVL**LTPQSTMPL*L*THLLDQ
SGWQDGAEELSNIKSGVGL*LN*LV*TCLNTTS
PDSTGWFPSKIYKLSSRAAVLLSFP*LLRNFLT
GNNGNTPSELKQTNRNKTY*PAKSPNHQSWVLLK
GRSVFYLLPSEQTL*MSSLKFCLP*SSLVN*LG
S*G*GLNQLKIVSKYVPGCVCTCRACPLHVPRA
SNSLWQRHVKYSDFFFFNLIPFPMKWIFKNFLQS
VPYFSSYYS*CVCILVYMCVCVCICVFLVVTCL
LGNYVNKHRFIGQLGLRKEDIIKGGSILTLAKA
ITQGTHSAPLNSHSPLRPCLTNKGKGWR*YFSQN
RRGFEHICNITLSTHEQKF*ITSRTPEAH*IKE
CGAPQSYQRLSADFSAIE*PWSILMVRGRTEKR
VETIALALPSVLCLLMFCLSKIYFLLIV*LAK*W
LLWELFVCLGRPWPAL*K*AKSILPSTSIRTEN
ALILGSLKIASFMAHWVDDSSRGSLHGTLLLFC
RSQYNSFPLSVPRPPHC*LQQFDIIFPFQLQRR*
*EAIK*CFKKAT*VS*KKGNEYMLHNYI*NVSH
VIISRTEMKIC*QTSFKHTHSEVKSCF*HLTIG
*YYSLLSKEKYHPSIVYLDLLEETLQS*AWCLKR
KTKIKIMDLGQGDRVIF*RLCLLPHHRPTKMEF
CILHISDISVQFHQSISDVLEASQQMEDPNVFV
LGISQGPA*LECVYQQDESNQATPPFWFRIGHSC
MC**IVDQDQLSKHSCRVASYVAKKLLLPRCFE
QLSAPSG*VEMAPPEFFLDVRLNPLRQLL*QSE
GFLPGKCSFSLSLLILPACESNHRSWASSQINCH
ARSPSWGAVMLL*G*LLRL*WVFVCFCLVFLDC
SSFS*MAREETLSLTHGQEGNGERATS*FNLVA
T*RNLSPWTQPLTGSKSHCPLRLREQPEEEMNPF
CPLFGFASCQ*ENAEAVPVM*NFHF*NQDSPKQ
TGMSWSIPVGIGPMIFASKIGLSSSPKMPSSAL
KWVF*NKNK*CRFSRKPGKHKKQR*NEKSHVIPP
VRVNH*YRLDIWLSSLVDILLISCNIKSDHMCP
CICLYWTLLIFL**WLTLGRLCCTVCRKHIGCI
IPSFVFCISLEMCRG*ERGSGHSWPRQTLIW*VS
QST*GLCYALERLRK*EALLF*QGRLRALI*GH
HSR*LQMQFIAQLKQMITFCLQVLHPS*LLSKS
RVCWILKGQTSYISYIS*CLGMPSLPSRIPWLCK
DL**LESPFGHSQLCLNLMEFAVQ*SPDLSS*K
PSFLS*CLRPLDLDWGSGKEASINSMTSNNMLV
LIFCTVILSLRDYKNEFK*ISSCDVRD*ICVISE
PKAGGNPRKKTII*S*FLYIIFIHYCIWVEINI
LSYAVTIN*HIF*PCH*TFGCIKVEPKLLIR**
WHLD*VPYS*ISNKVVDIERTG*SPIVCSYIKTA
SLHFRECLY*RLHEMSAYKISRDGTTKQPPELF
SYRNDYFSDPFMFSCSILTPLPCNTQRVYFCKS
FGLQSTTEE*RGTNCFTQDQNSCSYLLLIEYLSQ
MD*LVSHFLYLGFTSININIFTHMIFPSSHFFP
YVLGFRNYDANDHISS*FLISLVPFPDIYRNNY
QYM*LLEPYLEG*PFFSKCCQNVYI*SVFFPFRS
LCSGLMAKFLFLHVRFLISLNST*IFMDIGF*R
GKHSFS**DIGDT*LCH*FPYS*ALGRETVAK*
QAE*DHHSCPESITLSFSDCVYALPLPTYYILSF
*VKWILARFESNG*FIGIVLGVNISVSSLVLFE
DSCH*GPLCLHLSQYEEELWCEGGAM*RVAGLG
D*FIWSPCHLFTFGERGL*VGGYG*MFLKETLLA
NGHYICVLL*FSL*APHVAKDPPPTRALPATSL
HWSQPFSLLLLHHVGLR*DREGVLLIAKCCLTL
FPSPTFHARERT*HMTCILFLCSETPGLAHVYV*
VTNGAWNSLSI*SVRK*DLLYWNL*CS*SFRAK
RIYQ*RQDCHI
Sequence NM_006180
AAGACGGATTCTCAGACAAGGCTTGCAAATGCCCCGCAGCCATCATTTAACTGCACCCGCAGAATAGTTACGGTTTGTCACCCGACCCTCCCGGATCGCCTAATTTGTCCCTAGTGAGACCCCGAGGCTCTGCCCGCGCCTGGCTTCTTCGTAGCTGGATGCATATCGTGCTCCGGGCAGCGCGGGCGCAGGGCACGCGT
TCGCGCACACCCTAGCACACATGAACACGCGCAAGAGCTGAACCAAGCACGGTTTCCATTTCAAAAAGGGAGACAGCCTCTACCGCGATTGTAGAAGAGA
CTGTGGTGTGAATTAGGGACCGGGAGGCGTCGAACGGAGGAACGGTTCATCTTAGAGACTAATTTTCTGGAGTTTCTGCCCCTGCTCTGCGTCAGCCCTC
ACGTCACTTCGCCAGCAGTAGCAGAGGCGGCGGCGGCGGCTCCCGGAATTGGGTTGGAGCAGGAGCCTCGCTGGCTGCTTCGCTCGCGCTCTACGCGCTC
AGTCCCCGGCGGTAGCAGGAGCCTGGACCCAGGCGCCGCCGGCGGGCGTGAGGCGCCGGAGCCCGGCCTCGAGGTGCATACCGGACCCCCATTCGCATCT
AACAAGGAATCTGCGCCCCAGAGAGTCCCGGGAGCGCCGCCGGTCGGTGCCCGGCGCGCCGGGCCATGCAGCGACGGCCGCCGCGGAGCTCCGAGCAGCG
GTAGCGCCCCCCTGTAAAGCGGTTCGCTATGCCGGGGCCACTGTGAACCCTGCCGCCTGCCGGAACACTCTTCGCTCCGGACCAGCTCAGCCTCTGATAA
GCTGGACTCGGCACGCCCGCAACAAGCACCGAGGAGTTAAGAGAGCCGCAAGCGCAGGGAAGGCCTCCCCGCACGGGTGGGGGAAAGCGGCCGGTGCAGC
GCGGGGACAGGCACTCGGGCTGGCACTGGCTGCTAGGGATGTCGTCCTGGATAAGGTGGCATGGACCCGCCATGGCGCGGCTCTGGGGCTTCTGCTGGCT
GGTTGTGGGCTTCTGGAGGGCCGCTTTCGCCTGTCCCACGTCCTGCAAATGCAGTGCCTCTCGGATCTGGTGCAGCGACCCTTCTCCTGGCATCGTGGCA
TTTCCGAGATTGGAGCCTAACAGTGTAGATCCTGAGAACATCACCGAAATTTTCATCGCAAACCAGAAAAGGTTAGAAATCATCAACGAAGATGATGTTG
AAGCTTATGTGGGACTGAGAAATCTGACAATTGTGGATTCTGGATTAAAATTTGTGGCTCATAAAGCATTTCTGAAAAACAGCAACCTGCAGCACATCAA
TTTTACCCGAAACAAACTGACGAGTTTGTCTAGGAAACATTTCCGTCACCTTGACTTGTCTGAACTGATCCTGGTGGGCAATCCATTTACATGCTCCTGT
GACATTATGTGGATCAAGACTCTCCAAGAGGCTAAATCCAGTCCAGACACTCAGGATTTGTACTGCCTGAATGAAAGCAGCAAGAATATTCCCCTGGCAA
ACCTGCAGATACCCAATTGTGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGC
AGGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGGATAACTAAC
ATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTCACTGTGCATTTTGCACCAA
CTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCCAAACCAGCGCTTCAGTGGTTCTATAACGG
GGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAGTACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATG
AACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAGAAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTG
CAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGAACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGA
CGTCACTGATAAAACCGGTCGGGAACATCTCTCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTT
AAGTTGGCAAGACACTCCAAGTTTGGCATGAAAGATTTCTCATGGTTTGGATTTGGGAAAGTAAAATCAAGACAAGGTGTTGGCCCAGCCTCCGTTATCA
GCAATGATGATGACTCTGCCAGCCCACTCCATCACATCTCCAATGGGAGTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAAT
GACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAACAGTCAGCTCAAGCCAGACACATTTGTTCAGCACATCAAGCGACATAACATT
GTTCTGAAAAGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGA
AGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATGG
CGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCTG
ATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGCGTCCCAGCACT
TCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGA
CTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGC
CTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCC
TGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATAC
CCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACG
GGCTGAGAGGATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGA
GGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTCT
TTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTCT
GCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTCCTGCCTTTGAT
GTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATT
ATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAAC
CAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAA
CTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCAT
CACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGT
GATGATAGCACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCA
GGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACCC
CTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACTGCTCCAGACGT
CGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTTTATTAGCTGAGTATCAATGTCTCTGCGTT
GTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCT
AAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTC
ATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCT
GTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGG
TCAGATATACCAAGAAAGAAAAATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGC
CAGATTGAAAGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGT
TAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCAA
CTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGGGTCGTTTGTTCTCTTTGTT
GATGATTT
- refseq_NTRK2.F2 (forward primer)
- refseq_NTRK2.R2 (reverse primer)
- Single exon skipping
Frame 0
KTDSQTRLANAPQPSFNCTRRIVTVCHPTLPDRLICP**DPEALPAPGFFVAGCISCSGQRGRRARV
RAHPSTHEHAQELNQARFPFQKGRQPLPRL*KR
LWCELGTGRRRTEERFILETNFLEFLPLLCVSP
HVTSPAVAEAAAAAPGIGLEQEPRWLLRSRSTRS
VPGGSRSLDPGAAGGREAPEPGLEVHTGPPFAS
NKESAPQRVPGAPPVGARRAGPCSDGRRGAPSS
GSAPL*SGSLCRGHCEPCRLPEHSSLRTSSASDK
LDSARPQQAPRS*ESRKRREGLPARVGESGRCS
AGTGTRAGTGC*GCRPG*GGMDPPWRGSGASAG
WLWASGGPLSPVPRPANAVPLGSGAATLLLASWH
FRDWSLTV*ILRTSPKFSSQTRKG*KSSTKMML
KLMWD*EI*QLWILD*NLWLIKHF*KTATCSTS
ILPETN*RVCLGNISVTLTCLN*SWWAIHLHAPV
TLCGSRLSKRLNPVQTLRICTA*MKAARIFPWQ
TCRYPIVVCHLQIWPHLTSLWRKESLSHYPVVW
QVIRFLICIGMLVTWFPNI*MKQATHRAP*G*LT
FHPMTVGSRSLVWRKIL*EKIKILSTSLCILHQ
LSHFSNLQPQTTTGAFHSL*KATPNQRFSGSIT
GQY*MSPNTSVLKYMLPITRSTTAASSWIIPLT*
TMGTTL**PRMSMGRMRNRFLLTSWAGLELTMV
QTQIILM*FMKIMELQRMTSGTPRTEVMKSLPQ
TSLIKPVGNISRSMLWW*LRLWWDFAFW*CCFCL
SWQDTPSLA*KISHGLDLGK*NQDKVLAQPPLS
AMMMTLPAHSITSPMGVTLHLLRKVAQMLSLLE
*PRSLSLKIPSTLASPTVSSSQTHLFSTSSDITL
F*KGS*AKEPLEKCS*LNAITSVLSRTRSWWQ*
RP*RMPVTMHARTSTVRPSS*PTSSMSTSSSSM
ASAWRATPSSWSLST*SMGTSTSSSGHTALMPC*
WLRATRPRN*RSRRCCI*PSRSPRAWSTWRPST
SCTAIWPPGTAWSGRTCW*KSGTLGCPGTCTAL
TTTGSVATQCCPFAGCLQRASCTGNSRRKATSGA
WGSCCGRFSPMANSPGTSCQTMR**SVSLRAES
CSDPARAPRRCMS*CWGAGSESPT*GRTSRASI
PSFRTWPRHLRSTWTF*ARALFPRPILPNVLLRR
AERMNIF*LPLEATKLLSFTLTVLTSKTPRSSR
GKQCVLLHP*TQY*LLFGIISFSLSISLGCSFF
FF*IFFFFFFSSSLLHDSYPFF*INLASALLLTL
HRQRP*QT*FVISADTPVCPPQLTMPCCIPAFD
VDEKKGKQIFHLNFVTSAVQISRVSMDSLLFIY
YYYCSYCFWMA*ACV*KRKLVFNL*SLYLWEIKT
REKEDLL*TAIWEEQRQPLGSAGVSPYLGNTQQ
LLAGKNVFGTFP*GPF*GVKRLLASVPWMILFP
SPEMIACSREQRWLP*DTRWRIVCSDTVLSS*VV
MIALVCFSSAIHRTFVNFS*KEVDSCPELISGS
GGKAKNLEKIRQAINSEASFFYNELFRSHFPPT
PNFHAHPSF*LCKQNCAWSSSINTLCADTTAPDV
VSLIGRADP*KGMTYTIRGS*WSLLAEYQCLCV
VRW*WVLMNMDPEAWKSSSTSNPQDCGKGRINP
*GKGNLTLRASHALMFSVHRSSPLLWALVGRVVS
FQVYSIVSMLFLFPSLHSKSQNTKFGTACQREA
VPRPSTGSVLLGIVIGFAKRGLKFK*KFTAI*M
VRYTKKEKYFCSSRKLATLCEGNFAKLDIFIT*A
RLKGSDFHSS*VMLFHICF*RCDSSVLGFACAC
*LLEHLIFH*RL*KPILKNSKVQINRTKGNPVA
TAVKRGS*QDKPYVHSSYMLAYER*ELGRLFSLL
MI
Frame 1
RRILRQGLQMPRSHHLTAPAE*LRFVTRPSRIA*FVPSETPRLCPRLASS*LDAYRAPGSAGAGHA
FAHTLAHMNTRKS*TKHGFHFKKGDSLYRDCRRD
CGVN*GPGGVERRNGSS*RLIFWSFCPCSASAL
TSLRQQ*QRRRRRLPELGWSRSLAGCFARALRA
QSPAVAGAWTQAPPAGVRRRSPASRCIPDPHSHL
TRNLRPRESRERRRSVPGAPGHAATAAAELRAA
VAPPCKAVRYAGATVNPAACRNTLRSGPAQPLI
SWTRHARNKHRGVKRAASAGKASPHGWGKAAGAA
RGQALGLALAARDVVLDKVAWTRHGAALGLLLA
GCGLLEGRFRLSHVLQMQCLSDLVQRPFSWHRG
ISEIGA*QCRS*EHHRNFHRKPEKVRNHQRR*C*
SLCGTEKSDNCGFWIKICGS*SISEKQQPAAHQ
FYPKQTDEFV*ETFPSP*LV*TDPGGQSIYMLL
*HYVDQDSPRG*IQSRHSGFVLPE*KQQEYSPGK
PADTQLWFAICKSGRT*PHCGGRKVYHIIL*CG
R*SGS*YVLGCW*PGFQTYE*NKPHTGLLKDN*
HFIR*QWEADLLCGGKSCRRRSRFCQPHCAFCTN
YHISRISNLRPPLVHSIHCERQPQTSASVVL*R
GNIE*VQIHLY*NTCYQSHGVPRLPPAG*SHSH
EQWGLHSNSQE*VWEG*ETDFCSLHGLAWN*RWC
KPKLS*CNL*RLWNCSE*HRGHHEQK**NPFHR
RH**NRSGTSLGLCCGGDCVCGGILPFGNAVSA
*VGKTLQVWHERFLMVWIWESKIKTRCWPSLRYQ
Q***LCQPTPSHLQWE*HSIFFGRWPRCCHYWN
DQDPCH*KSPVLWHHQQSAQARHICSAHQAT*H
CSEKGARRRSLWKSVPS*ML*PLS*AGQDLGGSE
DPEGCQ*QCTQGLPP*GRAPDQPPA*AHRQVLW
RLRGGRPPHHGL*VHEAWGPQQVPQGTRP*CRA
DG*GQPAHGTDAVADAAYSPADRRGHGLPGVPAL
RAPRFGHQELPGRGELAGENRGLWDVPGRVQH*
LLQGRWPHNAAHSLDASREHHVQEIHDGKRRLE
PGGRVVGDFHLWQTALVPAVKQ*GDRVYHSGPSP
AATPHVPPGGV*ADAGVLAARAPHEEEHQGHPY
PPSELGQGISGLPGHSRLGPFSPDRSFPTYSSD
GLRG*TSFNCRWRPPSCSPSL*QY*HQRLREALE
GSSVYFFIHRHSIDFFLALSLSLFPSPLVVPFS
FFKFSFSFFFRLPCFTILTLSFESIWLLHYY*L
CIDKGLNKRNLLYQQTLQFAHHN*QCLVVFLPLM
WMKKRENKYFT*TLSLLLYRYREFLWIHFYLFI
IITVLIVFGWLKPVYKKENLCSICEAFIYGRLK
PERKKIYYEPQYGRNKDNHWDQLVSVPT*EILSN
C*LGRMYSAPSPEDLSEE*KDYWPLCHG*FFSH
HQK**RAVESKDGFRETQDGA*CARTQFCLRRL
***HWFVSQALSTEPLSTSVEKRWIHVQSSFRGQ
VGKPRTWKR*DKL*IRRQVSFTMNFSDLTSLRP
LTSMPTRPFNCASKIVHGLRRLIPCVQTLLLQT
SFP**VEQIHKKV*LIQLGEANGVY*LSINVSAL
YGGDGF**IWTLKPGNPHPRRTHRTVGRAESIP
KGKETSP*GHHMHSCSVYTGQVPCSGL*LGEWF
HSKCTPLSVCCFCFLHSIQKVKIQNLAQHANGRL
CPDQALEVCF*A*SLVLQKEGSNLNRNLQLFEW
SDIPRKKNISVPQENLLPSVRGILLNLTSL*HE
PD*KGVIFIHLRSCYFIFVSEGAIALF*VLLAPV
NYWNTLFFIKGFESQFSKIQKCKLTEQKEIQ*Q
LQSSEGVDKINLTSIQVICWPMRDESWVVCSLC
**F
Frame 2
DGFSDKACKCPAAII*LHPQNSYGLSPDPPGSPNLSLVRPRGSARAWLLRSWMHIVLRAARAQGTR
SRTP*HT*TRARAEPSTVSISKRETASTAIVEE
TVV*IRDREASNGGTVHLRD*FSGVSAPALRQPS
RHFASSSRGGGGGSRNWVGAGASLAASLALYAL
SPRR*QEPGPRRRRRA*GAGARPRGAYRTPIRI
*QGICAPESPGSAAGRCPARRAMQRRPPRSSEQR
*RPPVKRFAMPGPL*TLPPAGTLFAPDQLSL**
AGLGTPATSTEELREPQAQGRPPRTGGGKRPVQ
RGDRHSGWHWLLGMSSWIRWHGPAMARLWGFCWL
VVGFWRAAFACPTSCKCSASRIWCSDPSPGIVA
FPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHIN
FTRNKLTSLSRKHFRHLDLSELILVGNPFTCSC
DIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLA
NLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITN
ISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP
TITFLESPTSDHHWCIPFTVKGNPKPALQWFYNG
AILNESKYICTKIHVTNHTEYHGCLQLDNPTHM
NNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDG
ANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTD
VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL
KLARHSKFGMKDFSWFGFGKVKSRQGVGPASVI
SNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGM
TKIPVIENPQYFGITNSQLKPDTFVQHIKRHNI
VLKRELGEGAFGKVFLAECYNLCPEQDKILVAV
KTLKDASDNARKDFHREAELLTNLQHEHIVKFYG
VCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVL
MAEGNPPTELTQSQMLHIAQQIAAGMVYLASQH
FVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTD
YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWS
LGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV
LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHT
LLQNLAKASPVYLDILG*GPFPQTDPSQRTPQT
G*EDEHLLTAAGGHQAALLHSDSINIKDSEKLS
REAVCTSSSIDTVLTSFWHYLFLSFHLPWLFLFL
FLNFLFLFFFVFPASRFLPFLLNQSGFCITINS
A*TKALTNVICYISRHSSLPTTTNNALLYSCL*
CG*KKGKTNISLKLCHFCCTDIESFYGFTSIYLL
LLLFLLFLDGLSLCIKKKTCVQSVKPLSMGD*N
QRERRFIMNRNMGGTKTTTGISWCQSLLRKYSA
TVSWEECIRHLPLRTFLRSKKTTGLCAMDDSFPI
TRNDSVQ*RAKMASVRHKMAHSVLGHSFVFVGC
DDSTGLFLKRYPQNLCQLQLKRGGFMSRAHFGV
RWESQELGKDKTSYKFGGKFLLQ*TFQISLPSDP
*LPCPPVLLTVQAKLCMVFVD*YLVCRHYCSRR
RFPDR*SRSIKRYDLYN*GKLMEFIS*VSMSLR
CTVVMGFNEYGP*SLEILIHVEPTGLWEGQNQSL
RERKPHPEGITCTHVQCTQVKSLALGSSWESGF
IPSVLHCQYAVFVSFTPFKKSKYKIWHSMPTGG
CAQTKHWKCASRHSHWFCKKRAQI*IEIYSYLNG
QIYQERKIFLFLKKTCYPL*GEFC*T*HLYNMS
QIERE*FSFILGHVISYLFLKVR*LCFRFCLRL
LITGTPYFSLKALKANSQKFKSAN*QNKRKSSSN
CSQARELTR*TLRPFKLYAGL*EMRVGSFVLFV
DD
Sequence NM_001018065
AAGACGGATTCTCAGACAAGGCTTGCAAATGCCCCGCAGCCATCATTTAACTGCACCCGCAGAATAGTTACGGTTTGTCACCCGACCCTCCCGGATCGCCTAATTTGTCCCTAGTGAGACCCCGAGGCTCTGCCCGCGCCTGGCTTCTTCGTAGCTGGATGCATATCGTGCTCCGGGCAGCGCGGGCGCAGGGCACGCGT
TCGCGCACACCCTAGCACACATGAACACGCGCAAGAGCTGAACCAAGCACGGTTTCCATTTCAAAAAGGGAGACAGCCTCTACCGCGATTGTAGAAGAGA
CTGTGGTGTGAATTAGGGACCGGGAGGCGTCGAACGGAGGAACGGTTCATCTTAGAGACTAATTTTCTGGAGTTTCTGCCCCTGCTCTGCGTCAGCCCTC
ACGTCACTTCGCCAGCAGTAGCAGAGGCGGCGGCGGCGGCTCCCGGAATTGGGTTGGAGCAGGAGCCTCGCTGGCTGCTTCGCTCGCGCTCTACGCGCTC
AGTCCCCGGCGGTAGCAGGAGCCTGGACCCAGGCGCCGCCGGCGGGCGTGAGGCGCCGGAGCCCGGCCTCGAGGTGCATACCGGACCCCCATTCGCATCT
AACAAGGAATCTGCGCCCCAGAGAGTCCCGGGAGCGCCGCCGGTCGGTGCCCGGCGCGCCGGGCCATGCAGCGACGGCCGCCGCGGAGCTCCGAGCAGCG
GTAGCGCCCCCCTGTAAAGCGGTTCGCTATGCCGGGGCCACTGTGAACCCTGCCGCCTGCCGGAACACTCTTCGCTCCGGACCAGCTCAGCCTCTGATAA
GCTGGACTCGGCACGCCCGCAACAAGCACCGAGGAGTTAAGAGAGCCGCAAGCGCAGGGAAGGCCTCCCCGCACGGGTGGGGGAAAGCGGCCGGTGCAGC
GCGGGGACAGGCACTCGGGCTGGCACTGGCTGCTAGGGATGTCGTCCTGGATAAGGTGGCATGGACCCGCCATGGCGCGGCTCTGGGGCTTCTGCTGGCT
GGTTGTGGGCTTCTGGAGGGCCGCTTTCGCCTGTCCCACGTCCTGCAAATGCAGTGCCTCTCGGATCTGGTGCAGCGACCCTTCTCCTGGCATCGTGGCA
TTTCCGAGATTGGAGCCTAACAGTGTAGATCCTGAGAACATCACCGAAATTTTCATCGCAAACCAGAAAAGGTTAGAAATCATCAACGAAGATGATGTTG
AAGCTTATGTGGGACTGAGAAATCTGACAATTGTGGATTCTGGATTAAAATTTGTGGCTCATAAAGCATTTCTGAAAAACAGCAACCTGCAGCACATCAA
TTTTACCCGAAACAAACTGACGAGTTTGTCTAGGAAACATTTCCGTCACCTTGACTTGTCTGAACTGATCCTGGTGGGCAATCCATTTACATGCTCCTGT
GACATTATGTGGATCAAGACTCTCCAAGAGGCTAAATCCAGTCCAGACACTCAGGATTTGTACTGCCTGAATGAAAGCAGCAAGAATATTCCCCTGGCAA
ACCTGCAGATACCCAATTGTGGTTTGCCATCTGCAAATCTGGCCGCACCTAACCTCACTGTGGAGGAAGGAAAGTCTATCACATTATCCTGTAGTGTGGC
AGGTGATCCGGTTCCTAATATGTATTGGGATGTTGGTAACCTGGTTTCCAAACATATGAATGAAACAAGCCACACACAGGGCTCCTTAAGGATAACTAAC
ATTTCATCCGATGACAGTGGGAAGCAGATCTCTTGTGTGGCGGAAAATCTTGTAGGAGAAGATCAAGATTCTGTCAACCTCACTGTGCATTTTGCACCAA
CTATCACATTTCTCGAATCTCCAACCTCAGACCACCACTGGTGCATTCCATTCACTGTGAAAGGCAACCCCAAACCAGCGCTTCAGTGGTTCTATAACGG
GGCAATATTGAATGAGTCCAAATACATCTGTACTAAAATACATGTTACCAATCACACGGAGTACCACGGCTGCCTCCAGCTGGATAATCCCACTCACATG
AACAATGGGGACTACACTCTAATAGCCAAGAATGAGTATGGGAAGGATGAGAAACAGATTTCTGCTCACTTCATGGGCTGGCCTGGAATTGACGATGGTG
CAAACCCAAATTATCCTGATGTAATTTATGAAGATTATGGAACTGCAGCGAATGACATCGGGGACACCACGAACAGAAGTAATGAAATCCCTTCCACAGA
CGTCACTGATAAAACCGGTCGGGAACATCTCTCGGTCTATGCTGTGGTGGTGATTGCGTCTGTGGTGGGATTTTGCCTTTTGGTAATGCTGTTTCTGCTT
AAGTTGGCAAGACACTCCAAGTTTGGCATGAAAGATTTCTCATGGTTTGGATTTGGGAAAGTAAAATCAAGACAAGGTGTTGGCCCAGCCTCCGTTATCA
GCAATGATGATGACTCTGCCAGCCCACTCCATCACATCTCCAATGGGAGTAACACTCCATCTTCTTCGGAAGGTGGCCCAGATGCTGTCATTATTGGAAT
GACCAAGATCCCTGTCATTGAAAATCCCCAGTACTTTGGCATCACCAACAGTCAGCTCAAGCCAGACACATGGCCCAGAGGTTCCCCCAAGACCGCCTGA
TAATAATTTGGTATTTGGAGGCTCCTGTGTCACTGCAGGAACTAAAGGAGGCTAAATCCATGCCTGATGGAGGAGAAGAGTTCTATGGTTATCTGCAAAT
TCTGGCCAGACAACATCTTGACGTCACTCCTTAGCTTCCATAACCTAGCCAAGCAAGAAGTTGCCTTTCCAAGACAAAGCAGTGTGCTCTAATGACTAAC
CCCTCAAAGTACTATGCCACTTTAACTATAGACCCATCTCCTCGATCAATCAGGATGGCAAGATGGAGCTGAGGAGCTCAGCAACATCAAGTCTGGAGTT
GGTCTTTAACTCAACTAGCTCGTTTAGACGTGTCTGAACACCACATCACCTGACAGCACGGGGTGGTTTCCCAGTAAAATTTACAAACTCAGCTCAAGGG
CAGCTGTGTTGCTTTCCTTTCCTTGACTGCTGAGAAACTTTTTGACAGGGAACAATGGAAACACACCTTCTGAGCTGAAACAAACAAACAGAAACAAAAC
ATACTAACCAGCAAAATCCCCAAATCATCAATCTTGGGTTCTCTTGAAGGGCAGGAGTGTGTTTTATCTTCTCCCGTCGGAGCAAACACTATAGATGTCC
TCCCTAAAATTCTGTCTTCCCTAGAGCAGCCTTGTAAATTAGCTAGGGTCCTAGGGTTGAGGCCTAAATCAACTTAAAATTGTCTCTAAATATGTACCTG
GATGTGTTTGTACTTGCAGAGCATGCCCTCTTCATGTGCCTAGGGCTAGTAACTCCCTGTGGCAGAGGCATGTAAAGTATTCTGACTTTTTTTTTTTCAA
CTTAATTCCATTTCCAATGAAATGGATTTTTAAAAATTTTCTCCAGAGTGTGCCATACTTCTCCAGCTATTATAGTTAATGTGTGTGTATCCTTGTGTAT
ATGTGTGTTTGTGTGTGCATATGTGTTTTCCTAGTGGTTACATGCTTACTAGGCAATTATGTAAATAAGCACAGATTCATAGGCCAGCTAGGCCTGAGGA
AAGAAGACATTATAAAGGGAGGGAGTATTTTAACATTAGCTAAAGCTATCACACAAGGCACCCATTCTGCTCCCCTCAACAGCCACAGCCCACTTCGTCC
TTGTCTTACCAATAAGGGGAAAGGCTGGAGGTGATATTTTTCACAGAACCGCAGAGGTTTTGAACATATTTGCAACATTACTTTGAGTACACATGAGCAA
AAATTCTGAATTACATCCAGGACCCCAGAAGCTCATTAGATCAAAGAGTGCGGGGCCCCTCAGAGTTACCAGAGATTATCTGCAGACTTCAGTGCAATCG
AATGACCATGGTCCATTTTGATGGTCAGAGGTAGGACTGAAAAACGGGTAGAAACAATTGCTTTAGCGCTTCCTTCTGTACTTTGCCTATTAATGTTTTG
TCTTTCAAAAATATATTTTCTCCTAATTGTTTAATTGGCCAAATAATGGCTGCTTTGGGAGTTGTTTGTATGCCTTGGAAGGCCATGGCCTGCACTTTAA
AAATAAGCTAAGTCCATTCTGCCCAGCACGAGCATTAGGACAGAGAATGCACTTATTTTAGGATCCTTAAAAATTGCTTCTTTTATGGCACACTGGGTTG
ACGACTCATCTCGTGGGAGCCTTCATGGCACATTGCTGCTGTTCTGCAGGTCCCAATACAATTCCTTCCCCCTCTCAGTGCCACGGCCCCCCCATTGCTA
GCTACAACAATTTGATATCATATTCCCTTTTCAACTCCAAAGGAGATGATAAGAAGCTATCAAATAATGCTTTAAAAAAGCAACTTGAGTTTCTTAAAAG
AAAGGAAATGAATACATGCTGCATAATTACATTTAAAATGTAAGCCATGTTATTATAAGCCGCACTGAGATGAAGATTTGTTAGCAAACCAGTTTCAAGC
ACACTCACAGTGAAGTAAAATCATGTTTTTAGCATCTGACCATTGGGTAATATTATTCTTTGTTATCAAAAGAGAAATATCACCCAAGTATAGTATACTT
AGACCTCCTAGAGGAAACACTCCAGTCCTAAGCTTGGTGTCTGAAAAGAAAAACAAAAATAAAGATTATGGATTTAGGTCAGGGAGACAGAGTGATATTC
TGAAGACTGTGTTTACTCCCTCATCATCGGCCAACCAAGATGGAGTTCTGCATCCTGCACATATCAGACATTTCAGTCCAATTTCACCAAAGCATCAGTG
ATGTTCTAGAAGCATCCCAGCAGATGGAGGATCCTAATGTATTTGTTCTGGGTATTTCCCAAGGCCCAGCCTGACTGGAGTGTGTGTACCAACAGGATGA
ATCCAATCAAGCTACGCCCCCATTTTGGTTTCGGATTGGCCACTCTTGCATGTGCTAGTAGATTGTGGACCAGGACCAGCTGAGCAAACACAGTTGCAGA
GTAGCCTCCTATGTTGCTAAGAAGCTCCTGCTACCCAGGTGCTTTGAACAATTGAGTGCTCCCTCTGGTTAAGTAGAGATGGCACCACCGGAGTTTTTCT
TGGATGTGAGGCTCAATCCTTTACGGCAGCTATTATAACAAAGTGAAGGTTTTCTCCCTGGGAAATGCAGCTTTTCTCTGTCTTTACTAATTCTGCCAGC
CTGTGAGAGTAACCACCGTAGCTGGGCTTCTTCTCAGATTAATTGTCATGCCAGGTCTCCTTCCTGGGGAGCTGTGATGCTGCTCTGAGGTTGATTGCTG
AGGTTGTAGTGGGTTTTTGTTTGTTTTTGTTTAGTTTTTCTTGATTGTTCTTCTTTCTCTTGAATGGCAAGAGAAGAAACACTTTCTCTAACCCACGGCC
AGGAAGGAAATGGGGAGAGAGCTACTTCTTAGTTCAACCTGGTTGCCACATAAAGGAATCTCTCTCCTTGGACTCAGCCCCTAACTGGAAGCAAGAGCCA
CTGCCCTCTGAGACTGAGAGAGCAGCCCGAGGAGGAGATGAATCCATTCTGCCCTTTGTTTGGGTTTGCTTCCTGTCAGTGAGAGAATGCTGAGGCAGTT
CCTGTTATGTGAAACTTTCATTTTTAAAACCAGGACAGTCCTAAACAGACTGGAATGAGTTGGTCAATCCCAGTTGGTATAGGCCCAATGATTTTTGCTA
GTAAGATAGGATTGTCTTCCTCACCCAAAATGCCTTCAAGTGCCCTAAAATGGGTATTTTAAAATAAGAATAAATAATGTAGATTTAGTAGAAAACCTGG
AAAACATAAGAAACAAAGATGAAACGAAAAGTCCCATGTAATTCCACCAGTTAGAGTTAACCACTGATATCGTTTGGATATATGGCTTTCTAGTCTTGTG
GATATCCTTTTAATCTCTTGTAATATAAAGTCTGACCATATGTGTCCTTGCATTTGTTTGTACTGGACTCTGTTAATATTTCTATAGTAATGGCTCACTT
TGGGGAGATTGTGCTGCACAGTGTGTAGGAAGCACATTGGGTGTATTATTCCCAGTTTTGTATTTTGTATTTCCTTGGAGATGTGCAGGGGTTAAGAGCG
GGGGTCTGGCCATAGCTGGCCACGTCAGACTCTCATATGGTAAGTATCACAGAGCACATGAGGCCTGTGTTATGCGCTGGAAAGACTCAGGAAATGAGAG
GCTCTCTTGTTCTGACAAGGCAGGCTGAGAGCTCTCATTTAGGGTCATCACTCCAGATAACTCCAAATGCAGTTTATTGCTCAACTGAAGCAGATGATCA
CTTTTTGCCTCCAAGTTCTTCACCCTAGCTAGCTCCTTTCAAAGAGCCGAGTATGCTGGATCTTAAAGGGCCAAACTAGTTACATCTCATACATTTCCTG
ATGTTTAGGGATGCCTTCACTTCCATCAAGGATACCTTGGCTGTGCAAGGACCTCTGATAGCTGGAGTCTCCTTTTGGTCACTCCCAGCTTTGCTTAAAC
TTGATGGAGTTTGCTGTCCAGTGATCCCCGGATCTTTCATCATGAAAGCCTTCCTTCCTCTCCTGATGTCTCAGGCCTCTAGACCTAGACTGGGGTTCTG
GCAAGGAGGCCTCTATCAATAGTATGACATCCAATAATATGTTAGTGTTGATATTTTGCACAGTAATATTAAGTTTAAGAGATTATAAAAATGAGTTCAA
ATGAATAAGTTCCTGTGATGTAAGAGATTAGATATGTGTGATTTCAGAACCAAAGGCAGGGGGGAATCCCAGAAAGAAAACAATAATATAATCCTAGTTT
CTATATATTATTTTTATTCATTACTGTATATGGGTAGAGATCAATATTCTTTCTTATGCTGTTACTATTAATTAACACATTTTTTAACCATGCCATTGAA
CTTTTGGGTGCATTAAAGTGGAACCCAAGCTCCTCATTAGATAATAATGGCATTTGGACTGAGTGCCATATTCCTAAATTTCCAATAAAGTGGTTGATAT
AGAGAGGACAGGATAAAGCCCTATAGTGTGCAGTTATATCAAAACAGCTAGTCTCCACTTTAGGGAATGCCTTTACTAGAGATTACATGAAATGTCTGCT
TATAAAATAAGCAGAGATGGCACCACTAAGCAGCCACCTGAATTGTTTTCCTACAGGAATGATTACTTTTCAGATCCATTTATGTTTTCATGCTCAATAC
TTACTCCCCTTCCCTGCAACACCCAAAGAGTTTACTTTTGCAAGTCATTTGGTCTTCAGTCTACTACTGAGGAATAGAGAGGCACTAACTGCTTTACCCA
GGATCAGAACTCATGTTCTTACCTTCTATTAATAGAGTACTTGAGCCAGATGGACTAACTGGTCTCACATTTTCTCTATCTTGGTTTTACTTCCATAAAC
ATCAATATCTTTACCCACATGATTTTTCCATCCTCCCATTTTTTTCCATATGTATTAGGGTTCAGGAACTATGATGCTAATGATCACATTTCTTCCTAGT
TCCTAATTTCATTAGTGCCATTTCCTGATATCTACAGAAACAATTATCAATACATGTAGCTGCTTGAGCCTTATTTAGAAGGCTAGCCTTTCTTTTCCAA
GTGCTGTCAGAATGTATACATTTAGTCTGTCTTTTTCCCTTTTAGGAGTCTTTGTTCTGGGTTGATGGCAAAATTCCTCTTTTTACATGTGAGATTTTTG
ATTTCACTGAATTCTACCTAGATTTTTATGGACATTGGATTTTAAAGAGGAAAACACTCATTTTCTTAGTAAGATATTGGTGATACATAGCTATGCCATT
GATTTCCATACTCCTGAGCTTTGGGGAGGGAGACAGTGGCCAAGTAGCAGGCAGAATAAGATCATCACTCATGTCCTGAATCAATCACACTTTCCTTCTC
GGATTGTGTATATGCTCTGCCACTTCCTACATATTACATCCTGAGTTTTTAAGTAAAGTGGATCTTAGCCAGATTTGAGTCTAATGGCTGATTCATCGGC
ATAGTTCTTGGCGTTAACATCTCAGTGTCCTCTTTAGTTCTCTTTGAGGATTCATGTCATTGAGGGCCTTTGTGCCTCCACTTGTCTCAGTATGAGGAAG
AACTTTGGTGTGAGGGCGGAGCTATGTGAAGGGTTGCTGGGTTGGGGGATTAGTTCATATGGTCCCCATGCCATCTATTTACTTTTGGAGAGAGGGGACT
TTGAGTGGGTGGGTATGGATAGATGTTCCTCAAGGAAACCCTGCTGGCTAATGGGCACTACATCTGTGTATTACTGTGATTCTCTCTGTAAGCTCCCCAT
GTGGCCAAGGACCCCCCTCCTACCAGGGCACTTCCTGCCACCTCATTGCACTGGTCTCAACCATTCAGCCTGCTGCTGCTGCACCATGTTGGGCTGCGGT
AGGATAGGGAAGGGGTTCTGTTGATTGCTAAATGTTGCCTAACTTTATTTCCCTCTCCCACATTTCATGCAAGGGAGCGGACCTAACACATGACTTGCAT
TCTCTTCCTATGTTCAGAAACTCCAGGGCTTGCCCACGTGTATGTATGAGTGACCAATGGAGCTTGGAATTCTTTATCTATATGATCTGTCCGAAAATGA
GATCTTTTGTACTGGAATTTGTGATGTAGTTGATCATTCAGAGCCAAACGCATATACCAATAAAGACAAGACTGTCATATA
- refseq_NTRK2.F2 (forward primer)
- refseq_NTRK2.R2 (reverse primer)
- Single exon skipping
Frame 0
KTDSQTRLANAPQPSFNCTRRIVTVCHPTLPDRLICP**DPEALPAPGFFVAGCISCSGQRGRRARV
RAHPSTHEHAQELNQARFPFQKGRQPLPRL*KR
LWCELGTGRRRTEERFILETNFLEFLPLLCVSP
HVTSPAVAEAAAAAPGIGLEQEPRWLLRSRSTRS
VPGGSRSLDPGAAGGREAPEPGLEVHTGPPFAS
NKESAPQRVPGAPPVGARRAGPCSDGRRGAPSS
GSAPL*SGSLCRGHCEPCRLPEHSSLRTSSASDK
LDSARPQQAPRS*ESRKRREGLPARVGESGRCS
AGTGTRAGTGC*GCRPG*GGMDPPWRGSGASAG
WLWASGGPLSPVPRPANAVPLGSGAATLLLASWH
FRDWSLTV*ILRTSPKFSSQTRKG*KSSTKMML
KLMWD*EI*QLWILD*NLWLIKHF*KTATCSTS
ILPETN*RVCLGNISVTLTCLN*SWWAIHLHAPV
TLCGSRLSKRLNPVQTLRICTA*MKAARIFPWQ
TCRYPIVVCHLQIWPHLTSLWRKESLSHYPVVW
QVIRFLICIGMLVTWFPNI*MKQATHRAP*G*LT
FHPMTVGSRSLVWRKIL*EKIKILSTSLCILHQ
LSHFSNLQPQTTTGAFHSL*KATPNQRFSGSIT
GQY*MSPNTSVLKYMLPITRSTTAASSWIIPLT*
TMGTTL**PRMSMGRMRNRFLLTSWAGLELTMV
QTQIILM*FMKIMELQRMTSGTPRTEVMKSLPQ
TSLIKPVGNISRSMLWW*LRLWWDFAFW*CCFCL
SWQDTPSLA*KISHGLDLGK*NQDKVLAQPPLS
AMMMTLPAHSITSPMGVTLHLLRKVAQMLSLLE
*PRSLSLKIPSTLASPTVSSSQTHGPEVPPRPPD
NNLVFGGSCVTAGTKGG*IHA*WRRRVLWLSAN
SGQTTS*RHSLASIT*PSKKLPFQDKAVCSND*
PLKVLCHFNYRPISSINQDGKMELRSSATSSLEL
VFNSTSSFRRV*TPHHLTARGGFPVKFTNSAQG
QLCCFPFLDC*ETF*QGTMETHLLS*NKQTETK
HTNQQNPQIINLGFS*RAGVCFIFSRRSKHYRCP
P*NSVFPRAAL*IS*GPRVEA*INLKLSLNMYL
DVFVLAEHALFMCLGLVTPCGRGM*SILTFFFS
T*FHFQ*NGFLKIFSRVCHTSPAIIVNVCVSLCI
CVFVCAYVFS*WLHAY*AIM*ISTDS*AS*A*G
KKTL*REGVF*H*LKLSHKAPILLPSTATAHFV
LVLPIRGKAGGDIFHRTAEVLNIFATLL*VHMSK
NSELHPGPQKLIRSKSAGPLRVTRDYLQTSVQS
NDHGPF*WSEVGLKNG*KQLL*RFLLYFAY*CF
VFQKYIFS*LFNWPNNGCFGSCLYALEGHGLHFK
NKLSPFCPARALGQRMHLF*DP*KLLLLWHTGL
TTHLVGAFMAHCCCSAGPNTIPSPSQCHGPPIA
SYNNLISYSLFNSKGDDKKLSNNALKKQLEFLKR
KEMNTCCIITFKM*AMLL*AALR*RFVSKPVSS
TLTVK*NHVFSI*PLGNIILCYQKRNITQV*YT
*TS*RKHSSPKLGV*KEKQK*RLWI*VRETE*YS
EDCVYSLIIGQPRWSSASCTYQTFQSNFTKASV
MF*KHPSRWRILMYLFWVFPKAQPDWSVCTNRM
NPIKLRPHFGFGLATLACASRLWTRTS*ANTVAE
*PPMLLRSSCYPGALNN*VLPLVK*RWHHRSFS
WM*GSILYGSYYNKVKVFSLGNAAFLCLY*FCQ
PVRVTTVAGLLLRLIVMPGLLPGEL*CCSEVDC*
GCSGFLFVFV*FFLIVLLSLEWQEKKHFL*PTA
RKEMGRELLLSSTWLPHKGISLLGLSP*LEARA
TAL*D*ESSPRRR*IHSALCLGLLPVSERMLRQF
LLCETFIFKTRTVLNRLE*VGQSQLV*AQ*FLL
VR*DCLPHPKCLQVP*NGYFKIRINNVDLVENL
ENIRNKDETKSPM*FHQLELTTDIVWIYGFLVLW
ISF*SLVI*SLTICVLAFVCTGLC*YFYSNGSL
WGDCAAQCVGSTLGVLFPVLYFVFPWRCAGVKS
GGLAIAGHVRLSYGKYHRAHEACVMRWKDSGNER
LSCSDKAG*ELSFRVITPDNSKCSLLLN*SR*S
LFASKFFTLASSFQRAEYAGS*RAKLVTSHTFP
DV*GCLHFHQGYLGCARTSDSWSLLLVTPSFA*T
*WSLLSSDPRIFHHESLPSSPDVSGL*T*TGVL
ARRPLSIV*HPIIC*C*YFAQ*Y*V*EIIKMSS
NE*VPVM*EIRYV*FQNQRQGGIPERKQ*YNPSF
YILFLFITVYG*RSIFFLMLLLLINTFFNHAIE
LLGALKWNPSSSLDNNGIWTECHIPKFPIKWLI
*RGQDKAL*CAVISKQLVSTLGNAFTRDYMKCLL
IK*AEMAPLSSHLNCFPTGMITFQIHLCFHAQY
LLPFPATPKEFTFASHLVFSLLLRNREALTALP
RIRTHVLTFY**ST*ARWTNWSHIFSILVLLP*T
SISLPT*FFHPPIFFHMY*GSGTMMLMITFLPS
S*FH*CHFLISTETIINTCSCLSLI*KASLSFP
SAVRMYTFSLSFSLLGVFVLG*WQNSSFYM*DF*
FH*ILPRFLWTLDFKEENTHFLSKILVIHSYAI
DFHTPELWGGRQWPSSRQNKIITHVLNQSHFPS
RIVYMLCHFLHITS*VFK*SGS*PDLSLMADSSA
*FLALTSQCPL*FSLRIHVIEGLCASTCLSMRK
NFGVRAELCEGLLGWGISSYGPHAIYLLLERGD
FEWVGMDRCSSRKPCWLMGTTSVYYCDSLCKLPM
WPRTPLLPGHFLPPHCTGLNHSACCCCTMLGCG
RIGKGFC*LLNVA*LYFPLPHFMQGSGPNT*LA
FSSYVQKLQGLPTCMYE*PMELGILYLYDLSENE
IFCTGICDVVDHSEPNAYTNKDKTVI
Frame 1
RRILRQGLQMPRSHHLTAPAE*LRFVTRPSRIA*FVPSETPRLCPRLASS*LDAYRAPGSAGAGHA
FAHTLAHMNTRKS*TKHGFHFKKGDSLYRDCRRD
CGVN*GPGGVERRNGSS*RLIFWSFCPCSASAL
TSLRQQ*QRRRRRLPELGWSRSLAGCFARALRA
QSPAVAGAWTQAPPAGVRRRSPASRCIPDPHSHL
TRNLRPRESRERRRSVPGAPGHAATAAAELRAA
VAPPCKAVRYAGATVNPAACRNTLRSGPAQPLI
SWTRHARNKHRGVKRAASAGKASPHGWGKAAGAA
RGQALGLALAARDVVLDKVAWTRHGAALGLLLA
GCGLLEGRFRLSHVLQMQCLSDLVQRPFSWHRG
ISEIGA*QCRS*EHHRNFHRKPEKVRNHQRR*C*
SLCGTEKSDNCGFWIKICGS*SISEKQQPAAHQ
FYPKQTDEFV*ETFPSP*LV*TDPGGQSIYMLL
*HYVDQDSPRG*IQSRHSGFVLPE*KQQEYSPGK
PADTQLWFAICKSGRT*PHCGGRKVYHIIL*CG
R*SGS*YVLGCW*PGFQTYE*NKPHTGLLKDN*
HFIR*QWEADLLCGGKSCRRRSRFCQPHCAFCTN
YHISRISNLRPPLVHSIHCERQPQTSASVVL*R
GNIE*VQIHLY*NTCYQSHGVPRLPPAG*SHSH
EQWGLHSNSQE*VWEG*ETDFCSLHGLAWN*RWC
KPKLS*CNL*RLWNCSE*HRGHHEQK**NPFHR
RH**NRSGTSLGLCCGGDCVCGGILPFGNAVSA
*VGKTLQVWHERFLMVWIWESKIKTRCWPSLRYQ
Q***LCQPTPSHLQWE*HSIFFGRWPRCCHYWN
DQDPCH*KSPVLWHHQQSAQARHMAQRFPQDRL
IIIWYLEAPVSLQELKEAKSMPDGGEEFYGYLQI
LARQHLDVTP*LP*PSQARSCLSKTKQCALMTN
PSKYYATLTIDPSPRSIRMARWS*GAQQHQVWS
WSLTQLARLDVSEHHIT*QHGVVSQ*NLQTQLKG
SCVAFLSLTAEKLFDREQWKHTF*AETNKQKQN
ILTSKIPKSSILGSLEGQECVLSSPVGANTIDV
LPKILSSLEQPCKLARVLGLRPKST*NCL*ICTW
MCLYLQSMPSSCA*G**LPVAEACKVF*LFFFQ
LNSISNEMDF*KFSPECAILLQLL*LMCVYPCV
YVCLCVHMCFPSGYMLTRQLCK*AQIHRPARPEE
RRHYKGREYFNIS*SYHTRHPFCSPQQPQPTSS
LSYQ*GERLEVIFFTEPQRF*TYLQHYFEYT*A
KILNYIQDPRSSLDQRVRGPSELPEIICRLQCNR
MTMVHFDGQR*D*KTGRNNCFSASFCTLPINVL
SFKNIFSPNCLIGQIMAALGVVCMPWKAMACTL
KIS*VHSAQHEH*DRECTYFRILKNCFFYGTLG*
RLISWEPSWHIAAVLQVPIQFLPPLSATAPPLL
ATTI*YHIPFSTPKEMIRSYQIML*KSNLSFLK
ERK*IHAA*LHLKCKPCYYKPH*DEDLLANQFQA
HSQ*SKIMFLASDHWVILFFVIKREISPKYSIL
RPPRGNTPVLSLVSEKKNKNKDYGFRSGRQSDI
LKTVFTPSSSANQDGVLHPAHIRHFSPISPKHQ*
CSRSIPADGGS*CICSGYFPRPSLTGVCVPTG*
IQSSYAPILVSDWPLLHVLVDCGPGPAEQTQLQ
SSLLCC*EAPATQVL*TIECSLWLSRDGTTGVFL
GCEAQSFTAAIITK*RFSPWEMQLFSVFTNSAS
L*E*PP*LGFFSD*LSCQVSFLGSCDAALRLIA
EVVVGFCLFLFSFS*LFFFLLNGKRRNTFSNPRP
GRKWGESYFLVQPGCHIKESLSLDSAPNWKQEP
LPSETERAARGGDESILPFVWVCFLSVREC*GS
SCYVKLSFLKPGQS*TDWNELVNPSWYRPNDFC*
*DRIVFLTQNAFKCPKMGILK*E*IM*I**KTW
KT*ETKMKRKVPCNSTS*S*PLISFGYMAF*SC
GYPFNLL*YKV*PYVSLHLFVLDSVNISIVMAHF
GEIVLHSV*EAHWVYYSQFCILYFLGDVQGLRA
GVWP*LATSDSHMVSITEHMRPVLCAGKTQEMR
GSLVLTRQAESSHLGSSLQITPNAVYCSTEADDH
FLPPSSSP*LAPFKEPSMLDLKGPN*LHLIHFL
MFRDAFTSIKDTLAVQGPLIAGVSFWSLPALLK
LDGVCCPVIPGSFIMKAFLPLLMSQASRPRLGFW
QGGLYQ*YDIQ*YVSVDILHSNIKFKRL*K*VQ
MNKFL*CKRLDMCDFRTKGRGESQKENNNIILV
SIYYFYSLLYMGRDQYSFLCCYY*LTHFLTMPLN
FWVH*SGTQAPH*IIMAFGLSAIFLNFQ*SG*Y
REDRIKPYSVQLYQNS*SPL*GMPLLEIT*NVC
L*NKQRWHH*AAT*IVFLQE*LLFRSIYVFMLNT
YSPSLQHPKSLLLQVIWSSVYY*GIERH*LLYP
GSELMFLPSINRVLEPDGLTGLTFSLSWFYFHK
HQYLYPHDFSILPFFSICIRVQEL*C**SHFFLV
PNFISAIS*YLQKQLSIHVAA*ALFRRLAFLFQ
VLSECIHLVCLFPF*ESLFWVDGKIPLFTCEIF
DFTEFYLDFYGHWILKRKTLIFLVRYW*YIAMPL
ISILLSFGEGDSGQVAGRIRSSLMS*INHTFLL
GLCICSATSYILHPEFLSKVDLSQI*V*WLIHR
HSSWR*HLSVLFSSL*GFMSLRAFVPPLVSV*GR
TLV*GRSYVKGCWVGGLVHMVPMPSIYFWREGT
LSGWVWIDVPQGNPAG*WALHLCITVILSVSSP
CGQGPPSYQGTSCHLIALVSTIQPAAAAPCWAAV
G*GRGSVDC*MLPNFISLSHISCKGADLTHDLH
SLPMFRNSRACPRVCMSDQWSLEFFIYMICPKM
RSFVLEFVM*LIIQSQTHIPIKTRLSY
Frame 2
DGFSDKACKCPAAII*LHPQNSYGLSPDPPGSPNLSLVRPRGSARAWLLRSWMHIVLRAARAQGTR
SRTP*HT*TRARAEPSTVSISKRETASTAIVEE
TVV*IRDREASNGGTVHLRD*FSGVSAPALRQPS
RHFASSSRGGGGGSRNWVGAGASLAASLALYAL
SPRR*QEPGPRRRRRA*GAGARPRGAYRTPIRI
*QGICAPESPGSAAGRCPARRAMQRRPPRSSEQR
*RPPVKRFAMPGPL*TLPPAGTLFAPDQLSL**
AGLGTPATSTEELREPQAQGRPPRTGGGKRPVQ
RGDRHSGWHWLLGMSSWIRWHGPAMARLWGFCWL
VVGFWRAAFACPTSCKCSASRIWCSDPSPGIVA
FPRLEPNSVDPENITEIFIANQKRLEIINEDDV
EAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHIN
FTRNKLTSLSRKHFRHLDLSELILVGNPFTCSC
DIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLA
NLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITN
ISSDDSGKQISCVAENLVGEDQDSVNLTVHFAP
TITFLESPTSDHHWCIPFTVKGNPKPALQWFYNG
AILNESKYICTKIHVTNHTEYHGCLQLDNPTHM
NNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDG
ANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTD
VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL
KLARHSKFGMKDFSWFGFGKVKSRQGVGPASVI
SNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGM
TKIPVIENPQYFGITNSQLKPDTWPRGSPKTA*
**FGIWRLLCHCRN*RRLNPCLMEEKSSMVICK
FWPDNILTSLLSFHNLAKQEVAFPRQSSVL**LT
PQSTMPL*L*THLLDQSGWQDGAEELSNIKSGV
GL*LN*LV*TCLNTTSPDSTGWFPSKIYKLSSR
AAVLLSFP*LLRNFLTGNNGNTPSELKQTNRNKT
Y*PAKSPNHQSWVLLKGRSVFYLLPSEQTL*MS
SLKFCLP*SSLVN*LGS*G*GLNQLKIVSKYVP
GCVCTCRACPLHVPRASNSLWQRHVKYSDFFFFN
LIPFPMKWIFKNFLQSVPYFSSYYS*CVCILVY
MCVCVCICVFLVVTCLLGNYVNKHRFIGQLGLR
KEDIIKGGSILTLAKAITQGTHSAPLNSHSPLRP
CLTNKGKGWR*YFSQNRRGFEHICNITLSTHEQ
KF*ITSRTPEAH*IKECGAPQSYQRLSADFSAI
E*PWSILMVRGRTEKRVETIALALPSVLCLLMFC
LSKIYFLLIV*LAK*WLLWELFVCLGRPWPAL*
K*AKSILPSTSIRTENALILGSLKIASFMAHWV
DDSSRGSLHGTLLLFCRSQYNSFPLSVPRPPHC*
LQQFDIIFPFQLQRR**EAIK*CFKKAT*VS*K
KGNEYMLHNYI*NVSHVIISRTEMKIC*QTSFK
HTHSEVKSCF*HLTIG*YYSLLSKEKYHPSIVYL
DLLEETLQS*AWCLKRKTKIKIMDLGQGDRVIF
*RLCLLPHHRPTKMEFCILHISDISVQFHQSIS
DVLEASQQMEDPNVFVLGISQGPA*LECVYQQDE
SNQATPPFWFRIGHSCMC**IVDQDQLSKHSCR
VASYVAKKLLLPRCFEQLSAPSG*VEMAPPEFF
LDVRLNPLRQLL*QSEGFLPGKCSFSLSLLILPA
CESNHRSWASSQINCHARSPSWGAVMLL*G*LL
RL*WVFVCFCLVFLDCSSFS*MAREETLSLTHG
QEGNGERATS*FNLVAT*RNLSPWTQPLTGSKSH
CPLRLREQPEEEMNPFCPLFGFASCQ*ENAEAV
PVM*NFHF*NQDSPKQTGMSWSIPVGIGPMIFA
SKIGLSSSPKMPSSALKWVF*NKNK*CRFSRKPG
KHKKQR*NEKSHVIPPVRVNH*YRLDIWLSSLV
DILLISCNIKSDHMCPCICLYWTLLIFL**WLT
LGRLCCTVCRKHIGCIIPSFVFCISLEMCRG*ER
GSGHSWPRQTLIW*VSQST*GLCYALERLRK*E
ALLF*QGRLRALI*GHHSR*LQMQFIAQLKQMI
TFCLQVLHPS*LLSKSRVCWILKGQTSYISYIS*
CLGMPSLPSRIPWLCKDL**LESPFGHSQLCLN
LMEFAVQ*SPDLSS*KPSFLS*CLRPLDLDWGS
GKEASINSMTSNNMLVLIFCTVILSLRDYKNEFK
*ISSCDVRD*ICVISEPKAGGNPRKKTII*S*F
LYIIFIHYCIWVEINILSYAVTIN*HIF*PCH*
TFGCIKVEPKLLIR**WHLD*VPYS*ISNKVVDI
ERTG*SPIVCSYIKTASLHFRECLY*RLHEMSA
YKISRDGTTKQPPELFSYRNDYFSDPFMFSCSI
LTPLPCNTQRVYFCKSFGLQSTTEE*RGTNCFTQ
DQNSCSYLLLIEYLSQMD*LVSHFLYLGFTSIN
INIFTHMIFPSSHFFPYVLGFRNYDANDHISS*
FLISLVPFPDIYRNNYQYM*LLEPYLEG*PFFSK
CCQNVYI*SVFFPFRSLCSGLMAKFLFLHVRFL
ISLNST*IFMDIGF*RGKHSFS**DIGDT*LCH
*FPYS*ALGRETVAK*QAE*DHHSCPESITLSFS
DCVYALPLPTYYILSF*VKWILARFESNG*FIG
IVLGVNISVSSLVLFEDSCH*GPLCLHLSQYEE
ELWCEGGAM*RVAGLGD*FIWSPCHLFTFGERGL
*VGGYG*MFLKETLLANGHYICVLL*FSL*APH
VAKDPPPTRALPATSLHWSQPFSLLLLHHVGLR
*DREGVLLIAKCCLTLFPSPTFHARERT*HMTCI
LFLCSETPGLAHVYV*VTNGAWNSLSI*SVRK*
DLLYWNL*CS*SFRAKRIYQ*RQDCHI
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