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Sequences

Sequence XM_374898

GGCGCATGCGCCACTGCAGGCTGGCGGTTCGCGGCTCCTTCTTCCGGCCTCCTCCTTAGGCCGGCACCAGCAGAAGCCGGGCGAGCGCGGAGCCCCAAGC AAGTGACCTGCGACCCCGAAAGTGGACCCCAGATCCTGGGGTTCTCCCTGGTCCGGAGACTAGGGAGCTGTCGCCTGCACCCCGGGAGCACCCACCCCAC GACCACCTCTGGATGCCGCCGACGGGTACCCGGCCCGTGCCCCGCGCCTGCCTGCCGGCTCGGCCCCTCGGAGCAATTCTGGGCCAGGAGTGGGGACCCG GACCCCGCCCCTGATGCAGCCCCACCCCCGCGTCCGGGCCTTGCACCACTGACTGTCCCGGCCGGCCCCGCCCCCTGCTCGCACCCTCGCGCGGCCGAGC CCCCCTCCCCCGCTGGGGGAGGCCATGGCGTGAGCGTGAGGCCGGGCCCCGGGGCCCTCAGGCGCCAGACGGGGCATGGGCCGGGGGCCGCCCCCATGAG GGTCCCGGGAGGGGGGGCGCGGGCAGCAGCGGCGGGGCCATGGGGTCGCAGGTGTTGCAGATCCTGCGCCAGGGGGTGTGGGCCTCGCTCACCGGCGGTT GGTTCTTCGACCCGCACCAGAGCACCTTCTCCAACTGCTTCCACCTCTATGTGTGGATCTTCCTGCTCATCTTTCCCTTCTTACTGTACATGGTCCTGCC TCCCAGCTTGATGGTGGCCGGCGTGTACTGCCTCGTGGTGGCTGTCATCTTTGCTACTATCAAGACTGTCAATTATCGGCTTCATGCCATGTTTGACCAG GGCGAGATCGTGGAGAAGCGCAGCTCTACCATGGGGGAGCTGGAGGAAGAGCCTGCCCAGGGGGACAGCAATCCACCCAGGGACCCCGGAGTGGAGATGA CAGTGTTCCGGAAAGTCAGTTCCACACCCCCGGTGCGCTGCAGCTCCCAGCACTCTGTGTTTGGCTTCAACCAGGTCTCGGAGCTGCTGCCCCGAATGGA GGACTCTGGGCCCCTTAGAGACATCAAGGAGCTGGTGCGGGAGCAGGGCAGCAACAATGTGATCGTGACTTCTGCCGACCGAGAGATGCTGAAGCTCAGC TCGCAGGAGAAACTGATTGGAGACCTTCCCCAGACGCCTCCAGGGGCTGTCCCAGACCCCTCTCTTGCCAGTACAGACTCTTCAGAGCCTTCTCCCCTGG CTGGAGATGGAGCGCCCTGGAGTGGGAGCAGCATGGCTGACACTCCCATGAGCCCCCTGCTGAAGGGGAGCCTCAGCCAGGAGCTGAGCAAGAGCTTCCT GACCCTGACCCAGCCTGACCGGGCCCTGGTGAGGACCAGCAGTCGACGGGAACAACGCAGGGGGGCAGGTGGCTATCAGCCCCTTGACCGGCGGGGCTCA GGGGAGCCCACGCCCCAGAAAGCCGGCTCCTCAGACTCCTGCTTCAGCGGCACTGACAGGGAGACATTGAGCAGCTTCAAGAGTGAGAAGACCAACTCCA CCCATCTGGACAGCCCCCCAGGGGGGCCAGCCCCTGAGGGCAGCGACACAGACCCACCCTCTGAGGCTGAGCTGCCTGCCTCACCAGACGCCGGGGTCCC CTCAGATGACACGCTGCGTTCCTTTGACACGGTCATTGGAGCAGGGACGCCACCGGGCCTGGCTGAGCCGCTCCTGGTCGTGCGGCCCAAGGACTTGGCC CTGCTACGGCCTAGCAAACGGCAGCCACCCCTGCGAAGACACTCTCCACCTGGCCGTGCCCCTCGACGGCCCCTGCTTGAAGGTGGGGGCTTCTTTGAGG ATGAAGACACTAGTGAGGGCAGTGAACTGAGCCCGGCCTCCAGTCTCCGATCGCAGCGCCGCTACAGTACTGACAGCTCCTCTTCTACTTCCTGCTACTC CCCTGAGAGCTCCCGGGGTGCAGCAGGGGGACCCCGGAAGCGGAGGGCCCCCCATGGGGCTGAGGAGGGAACTGCTGTGCCCCCCAAGCGGCCATATGGG ACCCAGCGGACGCCTAGTACCGCCAGCGCTAAAACACATGCCCGTGTGCTGAGCATGGATGGGGCTGGGGGTGATGTTCTGAGGCCCCCACTGGCTGGCT GCAAGGCAGAGCTGGAGGCCCAGGTTGGGGTGGAGCAGGCTGCTAGTGAGCCTGTTGTGCTGCCTGCTGAGGCGCGAAGGGGACCCGCTGCCAACCAGCC CGGCTGGCGGGGGGAGCTGCAGGAGGAAGGTGCTGTGGGGGGAGCGGCCGAGGAGACTGGCAGGCGGGACCGCTCAAGCAGTGTGAGGCGGACCCAGGCC ATTCGGAGACGCCACAATGCAGGCAGCAACCCCACCCCTCCAGCCTCTGTCATGGGCTCGCCGCCCAGCAGCCTGCAGGAAGCTCAGCGGGGCCGGGCTG CCTCCCACTCCCGGGCGCTGACGCTGCCCTCTGCGCTGCATTTCGCCTCTTCACTGTTGCTCACCCGGGCCGGTGCCAATGTGCATGAGGCCTGCACCTT TGATGACACTTCTGAGGGTGCTGTGCACTATTTCTACGATGAGAGCGGTGTGCGGCGTTCCTACACCTTTGGCCTGGCTGGAGGCGGCTACGAGAACCCT GTAGGGCAGCAAGGGGAGCAGACAGCTAATGGAGCCTGGGACCGACACTCGCATTCCTCCAGCTTCCACTCGGCTGATGTCCCTGAGGCTACAGGCGGCC TGAACCTGCTGCAGCCGAGGCCTGTGGTTCTGCAGGGCATGCAGGTGCGCCGGGTGCCCCTGGAGATCCCGGAGGAGCAGACACTGATGGAAGAAGCGCC ACCCCGGGCCCAGCATAGTTACAAGTACTGGCTTCTCCCTGGCCGCTGGACCTCTGTGCGCTATGAGCGGCTTGCCCTGCTGGCTCTGCTGGACCGGACG CGGGGAGTGCTGGAGAACATCTTCGGCGTGGGCCTGAGCAGCCTTGTGGCCTTCCTGGGCTACCTGCTGCTGCTCAAGGGCTTCTTCACTGACATCTGGG TCTTCCAGTTCTGCCTGGTCATCGCCTCCTGCCAGTACTCCTTGCTGAAGAGCGTGCAGCCTGATGCGGCGTCCCCCATGCACGGCCACAACTGGGTGAT CGCGTACAGCCGTCCTGTCTACTTCTGCATCTGCTGTCTGCTCATCTGGCTGCTGGACGCCCTGGGCTCAGCTCAGCCCTTCCCACCTGTCTCCCTCTAC GGCCTCACGCTCTTCTCTGCCTCCTTCTTCTTCTGTGCCCGAGACGTGGCCACTGTGTTCACCCTGTGCTTCCCCTTCGTCTTCCTCCTGGGCCTCCTGC CCCAGGTCAACACCTGCCTCATGTACCTGCTGGAGCAAATAGATATGCACGGCTTCGGGGGCACAGCTGCCACCAGCCCGCTCACGGCAGTCTTCAGCCT CTCCCGCAGCCTGCTGGCTGCTGCCCTGCTCTACGGTTTCTGCCTTGGGGCCATCAAGACTCCGTGGCCAGAGCAGCACGTCCCTGTCCTCTTCTCAGTC TTCTGTGGCCTCCTGGTGGCACTGTCCTACCACCTGAGCCGGCAGAGCAGCGACCCCACCGTGCTCTGGTCTCTGATCCGGAGCAAGCTGTTCCCTGAGC TGGAGGAGCGCAGCTTGGAGACAGCCCGGGCCGAGCCCCCGGACCCCTTGCCGGACAAGATGCGCCAGTCGGTGCGTGAGGTCTTGCACTCCGACCTGGT GATGTGTGTGGTGATCGCCGTGCTCACCTTCGCCATCAGCGCCAGCACCGTCTTTATTGCCCTGAAGTCGGTGCTGGGTTTCGTGTTGTACGCACTGGCT GGGGCCGTGGGCTTCTTCACACATTACCTGCTGCCACAACTCCGCAAACAGCTGCCCTGGTTCTGCCTGTCACAGCCCGTGCTGAAGCCGCTGGAGTACA GCCAGTATGAAGTGCGCGGTGCCGCCCAGGTGATGTGGTTTGAGAAGCTGTATGCTGGCCTGCAGTGCGTAGAGAAGTACCTCATCTACCCCGCCGTGGT GCTCAACGCCCTCACGGTGGACGCCCACACAGTCGTCAGCCACCCGGACAAGTACTGCTTCTACTGCCGGGCGCTGCTGATGACCGTGGCTGGGCTGAAG CTGCTGCGCTCAGCCTTCTGCTGCCCCCCACAGCAGTACCTGACGTTGGCCTTCACCGTCCTGCTCTTCCACTTTGACTACCCGCGCCTCTCCCAGGGCT TTCTGCTTGACTACTTCCTCATGTCCCTGCTTTGCAGCAAGCTGTGGGACTTGCTGTACAAGCTGCGTTTCGTGCTGACCTACATCGCGCCCTGGCAGAT CACCTGGGGCTCGGCTTTCCACGCTTTTGCCCAGCCGTTTGCCGTGCCACACTCGGCCATGCTGTTCGTCCAGGCCCTGCTCTCGGGGCTCTTCTCCACG CCTCTCAACCCACTGCTAGGCAGTGCCGTCTTCATCATGTCCTACGCTCGGCCCCTCAAGTTCTGGGAGCGCGACTACAACACTAAACGTGTGGATCATT CCAACACCCGCCTGGTCACACAGCTGGACAGGAACCCTGGCACTTACTGCCAGCAGCGCGAGGTGGAGGCTATCACCGAGGGTGTGGAGGAGGACGAGGG CTGTTGCTGCTGTGAACCTGGCCACCTGCCACGGGTCCTGTCCTTCAATGCTGCCTTTGGGCAGCGCTGGCTGGCTTGGGAGGTAACAGCCAGCAAGTAC GTGCTGGAGGGCTATAGCATTAGTGACAATAATGCTGCCTCCATGCTGCAGGTTTTCGACCTCCGCAAGATCCTCATCACCTACTATGTCAAGAGCATCA TCTACTACGTGAGCCGCTCACCAAAGCTGGAGGTGTGGCTCAGCCATGAGGGCATCACGGCAGCCCTGAGGCCTGTGCGGGTGCCCGGCTATGCCGACTC GGATCCCACCTTCTCGCTGAGTGTGGATGAGGACTATGACCTCCGCCTGTCTGGCCTCTCGCTGCCCTCCTTTTGTGCTGTGCACCTCGAGTGGATCCAG TACTGCGCCTCCCGGCGCAGCCAGCCCGTGGACCAGGATTGGAACTCCCCGCTGGTCACGCTGTGTTTTGGCCTGTGTGTGCTGGGCCGCCGGGCCCTGG GGACAGCCTCTCACAGCATGTCTGCAAGCCTGGAGCCCTTCCTCTACGGCCTGCACGCCCTGTTCAAGGGGGATTTTCGCATCACCTCCCCACGTGACGA GTGGGTCTTTGCCGACATGGACCTGCTTCACCGCGTTGTGGCGCCTGGGGTTCGCATGGCCCTCAAGCTTCACCAGGACCACTTCACGTCCCCAGATGAA TATGAGGAGCCAGCAGCCCTATACGATGCCATTGCGGCCAACGAGGAGCGGCTGGTCATCTCACATGAGGGTGACCCAGCATGGCGCAGCGCCATCCTCA GCAACACGCCCTCCCTGCTGGCGCTGCGCCATGTCCTGGATGATGCCTCCGACGAGTACAAGATCATCATGCTCAACCGGCGCCACCTCAGCTTCCGAGT CATCAAGGTGAACCGGGAGTGCGTGCGCGGCCTGTGGGCCGGGCAGCAGCAGGAGCTGGTGTTCCTGCGCAACCGCAACCCCGAGCGTGGCAGCATCCAG AACGCCAAGCAGGCGCTTCGCAACATGATCAACTCCTCCTGTGACCAGCCGCTGGGCTACCCCATCTACGTGTCGCCTCTCACCACCTCGCTGGCTGGCA GCCACCCCCAGCTACGGGCACTGTGGGGTGGCCCCATCAGCCTGGGTGCCATTGCCCACTGGCTCCTGCGCACCTGGGAGAGGCTTCACAAGGGCTGTGG CGCCGGCTGCAATAGTGGCGGGAACGTGGATGATTCAGACTGTAGTGGGGGCGGTGGCCTGACCTCCCTCAGCAATAACCCCCCCGTGGCACACCCCACA CCTGAGAACACGGCAGGCAATGGTGACCAACCCCTCCCACCAGGCCCTGGCTGGGGGCCGCGGTCCTCCCTGAGTGGCTCTGGTGATGGGCGGCCCCCAC CTCTGCTGCAGTGGCCTCCCCCTCGGCTCCCTGGACCACCCCCTGCATCGCCTATCCCCACAGAGGGTCCCCGGACCTCACGGCCCCCTGGCCCGGGTCT CCTCAGTTCTGAGGGCCCCAGTGGAAAGTGGAGCCTGGGGGGCCGGAAGGGGCTGGGAGGATCTGACGGGGAGCCAGCCTCAGGGAGCCCCAAAGGAGGT ACCCCCAAATCTCAGGCGCCTCTAGACCTCAGCCTCAGCCTCAGCCTCAGCCTCAGCCCCGATGTCAGCACTGAGGCCTCACCCCCCAGAGCTTCCCAGG ACATTCCTTGCTTGGACAGCAGTGCCCCTGAGAGTGGCACACCTATGGGTGCCCTGGGCGACTGGCCTGCCCCTATTGAGGAGCGTGAGAGCCCGGCAGC CCAGCCCCTGCTGGAACACCAGTACTGAGCTACCTGGCGCCCACTGGACCACCTCCTAGGATTCAGTAACGGACCTGCTCTGCTGCCTCTCTGCTGGACC ACAGAACTGAGTGGCTTTGGCCTACATGTCTGAACCCTGACCTTTGGCTGCCTTGGCCAGAGTACCAAAACTGAGTGACCCAGACCTCTGACCTTGACCC CTGATCTCTCTCATCCCCAGTCCAGGGCCTGGGCTCCCCAGATGGAGGCAGTCAGCCTCCCAGCCAGGCCCTAAGAGCCAAACCATGGGCTGGTCCCACT TGGAGCCTGTGGCCAGGACCACCTCAGCCCCTGGGCCTGCACTGCCTGCAGGTGTGGCCCCCTTGGCCTGGACCTGGGGCCTGAATTGTGGGAAGGGTGG TTTCTTTCTTTCCTTTTTTTTCTTTTCTTTTTTTTTTTTTTTTTTGTGCTTCGGAGACATCAGAATTAATAACACTATTTTTGATTTTGG

refseq_PCNXL3.F1 (forward primer)
refseq_PCNXL3.R1 (reverse primer)
Single exon skipping

Frame 0

GACATAGWRFAAPSSGLLLRPAPAEAGRARSPK QVTCDPESGPQILGFSLVRRLGSCRLHPGSTHPT TTSGCRRRVPGPCPAPACRLGPSEQFWARSGDP DPAPDAAPPPRPGLAPLTVPAGPAPCSHPRAAE PPSPAGGGHGVSVRPGPGALRRQTGHGPGAAPMR VPGGGARAAAAGPWGRRCCRSCARGCGPRSPAV GSSTRTRAPSPTASTSMCGSSCSSFPSYCTWSC LPA*WWPACTASWWLSSLLLSRLSIIGFMPCLTR ARSWRSAALPWGSWRKSLPRGTAIHPGTPEWR* QCSGKSVPHPRCAAAPSTLCLASTRSRSCCPEW RTLGPLETSRSWCGSRAATM*S*LLPTERC*SSA RRRN*LETFPRRLQGLSQTPLLPVQTLQSLLPW LEMERPGVGAAWLTLP*APC*RGASARS*ARAS *P*PSLTGPW*GPAVDGNNAGGQVAISPLTGGAQ GSPRPRKPAPQTPASAALTGRH*AASRVRRPTP PIWTAPQGGQPLRAATQTHPLRLSCLPHQTPGS PQMTRCVPLTRSLEQGRHRAWLSRSWSCGPRTWP CYGLANGSHPCEDTLHLAVPLDGPCLKVGASLR MKTLVRAVN*ARPPVSDRSAATVLTAPLLLPAT PLRAPGVQQGDPGSGGPPMGLRRELLCPPSGHMG PSGRLVPPALKHMPVC*AWMGLGVMF*GPHWLA ARQSWRPRLGWSRLLVSLLCCLLRREGDPLPTS PAGGGSCRRKVLWGERPRRLAGGTAQAV*GGPRP FGDATMQAATPPLQPLSWARRPAACRKLSGAGL PPTPGR*RCPLRCISPLHCCSPGPVPMCMRPAP LMTLLRVLCTISTMRAVCGVPTPLAWLEAATRTL *GSKGSRQLMEPGTDTRIPPASTRLMSLRLQAA *TCCSRGLWFCRACRCAGCPWRSRRSRH*WKKR HPGPSIVTSTGFSLAAGPLCAMSGLPCWLCWTGR GECWRTSSAWA*AALWPSWATCCCSRASSLTSG SSSSAWSSPPASTPC*RACSLMRRPPCTATTG* SRTAVLSTSASAVCSSGCWTPWAQLSPSHLSPST ASRSSLPPSSSVPETWPLCSPCASPSSSSWASC PRSTPASCTCWSK*ICTASGAQLPPARSRQSSA SPAACWLLPCSTVSALGPSRLRGQSSTSLSSSQS SVASWWHCPTT*AGRAATPPCSGL*SGASCSLS WRSAAWRQPGPSPRTPCRTRCASRCVRSCTPTW *CVW*SPCSPSPSAPAPSLLP*SRCWVSCCTHWL GPWASSHITCCHNSANSCPGSACHSPC*SRWST ASMKCAVPPR*CGLRSCMLACSA*RSTSSTPPW CSTPSRWTPTQSSATRTSTASTAGRC**PWLG*S CCAQPSAAPHSST*RWPSPSCSSTLTTRASPRA FCLTTSSCPCFAASCGTCCTSCVSC*PTSRPGR SPGARLSTLLPSRLPCHTRPCCSSRPCSRGSSPR LSTHC*AVPSSSCPTLGPSSSGSATTTLNVWII PTPAWSHSWTGTLALTASSARWRLSPRVWRRTR AVAAVNLATCHGSCPSMLPLGSAGWLGR*QPAST CWRAIALVTIMLPPCCRFSTSARSSSPTMSRAS STT*AAHQSWRCGSAMRASRQP*GLCGCPAMPT RIPPSR*VWMRTMTSACLASRCPPFVLCTSSGSS TAPPGAASPWTRIGTPRWSRCVLACVCWAAGPW GQPLTACLQAWSPSSTACTPCSRGIFASPPHVT SGSLPTWTCFTALWRLGFAWPSSFTRTTSRPQMN MRSQQPYTMPLRPTRSGWSSHMRVTQHGAAPSS ATRPPCWRCAMSWMMPPTSTRSSCSTGATSASE SSR*TGSACAACGPGSSRSWCSCATATPSVAASR TPSRRFAT*STPPVTSRWATPSTCRLSPPRWLA ATPSYGHCGVAPSAWVPLPTGSCAPGRGFTRAV APAAIVAGTWMIQTVVGAVA*PPSAITPPWHTPH LRTRQAMVTNPSHQALAGGRGPP*VALVMGGPH LCCSGLPLGSLDHPLHRLSPQRVPGPHGPLARV SSVLRAPVESGAWGAGRGWEDLTGSQPQGAPKEV PPNLRRL*TSASASASASAPMSALRPHPPELPR TFLAWTAVPLRVAHLWVPWATGLPLLRSVRARQ PSPCWNTSTELPGAHWTTS*DSVTDLLCCLSAGP QN*VALAYMSEP*PLAALARVPKLSDPDL*P*P LISLIPSPGPGLPRWRQSASQPGPKSQTMGWSH LEPVARTTSAPGPALPAGVAPLAWTWGLNCGKGG FFLSFFFFSFFFFFLCFGDIRINNTIFDF

Frame 1

AHAPLQAGGSRLLLPASSLGRHQQKPGERGAPS K*PATPKVDPRSWGSPWSGD*GAVACTPGAPTP RPPLDAADGYPARAPRLPAGSAPRSNSGPGVGTR TPPLMQPHPRVRALHH*LSRPAPPPARTLARPS PPPPLGEAMA*A*GRAPGPSGARRGMGRGPPP* GSREGGRGQQRRGHGVAGVADPAPGGVGLAHRRL VLRPAPEHLLQLLPPLCVDLPAHLSLLTVHGPA SQLDGGRRVLPRGGCHLCYYQDCQLSASCHV*P GRDRGEAQLYHGGAGGRACPGGQQSTQGPRSGDD SVPESQFHTPGALQLPALCVWLQPGLGAAAPNG GLWAP*RHQGAGAGAGQQQCDRDFCRPRDAEAQ LAGETDWRPSPDASRGCPRPLSCQYRLFRAFSPG WRWSALEWEQHG*HSHEPPAEGEPQPGAEQELP DPDPA*PGPGEDQQSTGTTQGGRWLSAP*PAGL RGAHAPESRLLRLLLQRH*QGDIEQLQE*EDQLH PSGQPPRGASP*GQRHRPTL*G*AACLTRRRGP LR*HAAFL*HGHWSRDATGPG*AAPGRAAQGLG PATA*QTAATPAKTLSTWPCPSTAPA*RWGLL*G *RH**GQ*TEPGLQSPIAAPLQY*QLLFYFLLL P*ELPGCSRGTPEAEGPPWG*GGNCCAPQAAIW DPADA*YRQR*NTCPCAEHGWGWG*CSEAPTGWL QGRAGGPGWGGAGC**ACCAAC*GAKGTRCQPA RLAGGAAGGRCCGGSGRGDWQAGPLKQCEADPG HSETPQCRQQPHPSSLCHGLAAQQPAGSSAGPGC LPLPGADAALCAAFRLFTVAHPGRCQCA*GLHL **HF*GCCALFLR*ERCAAFLHLWPGWRRLREP CRAARGADS*WSLGPTLAFLQLPLG*CP*GYRRP EPAAAEACGSAGHAGAPGAPGDPGGADTDGRSA TPGPA*LQVLASPWPLDLCAL*AACPAGSAGPD AGSAGEHLRRGPEQPCGLPGLPAAAQGLLH*HLG LPVLPGHRLLPVLLAEERAA*CGVPHARPQLGD RVQPSCLLLHLLSAHLAAGRPGLSSALPTCLPL RPHALLCLLLLLCPRRGHCVHPVLPLRLPPGPPA PGQHLPHVPAGANRYARLRGHSCHQPAHGSLQP LPQPAGCCPALRFLPWGHQDSVARAARPCPLLS LLWPPGGTVLPPEPAEQRPHRALVSDPEQAVP*A GGAQLGDSPGRAPGPLAGQDAPVGA*GLALRPG DVCGDRRAHLRHQRQHRLYCPEVGAGFRVVRTG WGRGLLHTLPAATTPQTAALVLPVTARAEAAGVQ PV*SARCRPGDVV*EAVCWPAVRREVPHLPRRG AQRPHGGRPHSRQPPGQVLLLLPGAADDRGWAE AAALSLLLPPTAVPDVGLHRPALPL*LPAPLPGL SA*LLPHVPALQQAVGLAVQAAFRADLHRALAD HLGLGFPRFCPAVCRATLGHAVRPGPALGALLH ASQPTARQCRLHHVLRSAPQVLGARLQH*TCGSF QHPPGHTAGQEPWHLLPAARGGGYHRGCGGGRG LLLL*TWPPATGPVLQCCLWAALAGLGGNSQQV RAGGL*H**Q*CCLHAAGFRPPQDPHHLLCQEHH LLREPLTKAGGVAQP*GHHGSPEACAGARLCRL GSHLLAECG*GL*PPPVWPLAALLLCCAPRVDP VLRLPAQPARGPGLELPAGHAVFWPVCAGPPGPG DSLSQHVCKPGALPLRPARPVQGGFSHHLPT*R VGLCRHGPASPRCGAWGSHGPQASPGPLHVPR* I*GASSPIRCHCGQRGAAGHLT*G*PSMAQRHPQ QHALPAGAAPCPG*CLRRVQDHHAQPAPPQLPS HQGEPGVRARPVGRAAAGAGVPAQPQPRAWQHP ERQAGASQHDQLLL*PAAGLPHLRVASHHLAGWQ PPPATGTVGWPHQPGCHCPLAPAHLGEASQGLW RRLQ*WRERG*FRL*WGRWPDLPQQ*PPRGTPH T*EHGRQW*PTPPTRPWLGAAVLPEWLW*WAAPT SAAVASPSAPWTTPCIAYPHRGSPDLTAPWPGS PQF*GPQWKVEPGGPEGAGRI*RGASLREPQRR YPQISGASRPQPQPQPQPQPRCQH*GLTPQSFPG HSLLGQQCP*EWHTYGCPGRLACPY*GA*EPGS PAPAGTPVLSYLAPTGPPPRIQ*RTCSAASLLD HRTEWLWPTCLNPDLWLPWPEYQN*VTQTSDLDP *SLSSPVQGLGSPDGGSQPPSQALRAKPWAGPT WSLWPGPPQPLGLHCLQVWPPWPGPGA*IVGRV VSFFPFFSFLFFFFFCASETSELITLFLIL

Frame 2

RMRHCRLAVRGSFFRPPP*AGTSRSRASAEPQA SDLRPRKWTPDPGVLPGPETRELSPAPREHPPH DHLWMPPTGTRPVPRACLPARPLGAILGQEWGP GPRP*CSPTPASGPCTTDCPGRPRPLLAPSRGRA PLPRWGRPWREREAGPRGPQAPDGAWAGGRPHE GPGRGGAGSSGGAMGSQVLQILRQGVWASLTGG WFFDPHQSTFSNCFHLYVWIFLLIFPFLLYMVLP PSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQ GEIVEKRSSTMGELEEEPAQGDSNPPRDPGVEM TVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRME DSGPLRDIKELVREQGSNNVIVTSADREMLKLS SQEKLIGDLPQTPPGAVPDPSLASTDSSEPSPL AGDGAPWSGSSMADTPMSPLLKGSLSQELSKSFL TLTQPDRALVRTSSRREQRRGAGGYQPLDRRGS GEPTPQKAGSSDSCFSGTDRETLSSFKSEKTNS THLDSPPGGPAPEGSDTDPPSEAELPASPDAGVP SDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDLA LLRPSKRQPPLRRHSPPGRAPRRPLLEGGGFFE DEDTSEGSELSPASSLRSQRRYSTDSSSSTSCYS PESSRGAAGGPRKRRAPHGAEEGTAVPPKRPYG TQRTPSTASAKTHARVLSMDGAGGDVLRPPLAG CKAELEAQVGVEQAASEPVVLPAEARRGPAANQP GWRGELQEEGAVGGAAEETGRRDRSSSVRRTQA IRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRA ASHSRALTLPSALHFASSLLLTRAGANVHEACTF DDTSEGAVHYFYDESGVRRSYTFGLAGGGYENP VGQQGEQTANGAWDRHSHSSSFHSADVPEATGG LNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAP PRAQHSYKYWLLPGRWTSVRYERLALLALLDRT RGVLENIFGVGLSSLVAFLGYLLLLKGFFTDIW VFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVI AYSRPVYFCICCLLIWLLDALGSAQPFPPVSLY GLTLFSASFFFCARDVATVFTLCFPFVFLLGLL PQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSL SRSLLAAALLYGFCLGAIKTPWPEQHVPVLFSV FCGLLVALSYHLSRQSSDPTVLWSLIRSKLFPE LEERSLETARAEPPDPLPDKMRQSVREVLHSDLV MCVVIAVLTFAISASTVFIALKSVLGFVLYALA GAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEY SQYEVRGAAQVMWFEKLYAGLQCVEKYLIYPAVV LNALTVDAHTVVSHPDKYCFYCRALLMTVAGLK LLRSAFCCPPQQYLTLAFTVLLFHFDYPRLSQG FLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQI TWGSAFHAFAQPFAVPHSAMLFVQALLSGLFST PLNPLLGSAVFIMSYARPLKFWERDYNTKRVDH SNTRLVTQLDRNPGTYCQQREVEAITEGVEEDEG CCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKY VLEGYSISDNNAASMLQVFDLRKILITYYVKSI IYYVSRSPKLEVWLSHEGITAALRPVRVPGYADS DPTFSLSVDEDYDLRLSGLSLPSFCAVHLEWIQ YCASRRSQPVDQDWNSPLVTLCFGLCVLGRRAL GTASHSMSASLEPFLYGLHALFKGDFRITSPRDE WVFADMDLLHRVVAPGVRMALKLHQDHFTSPDE YEEPAALYDAIAANEERLVISHEGDPAWRSAIL SNTPSLLALRHVLDDASDEYKIIMLNRRHLSFRV IKVNRECVRGLWAGQQQELVFLRNRNPERGSIQ NAKQALRNMINSSCDQPLGYPIYVSPLTTSLAG SHPQLRALWGGPISLGAIAHWLLRTWERLHKGCG AGCNSGGNVDDSDCSGGGGLTSLSNNPPVAHPT PENTAGNGDQPLPPGPGWGPRSSLSGSGDGRPP PLLQWPPPRLPGPPPASPIPTEGPRTSRPPGPGL LSSEGPSGKWSLGGRKGLGGSDGEPASGSPKGG TPKSQAPLDLSLSLSLSLSPDVSTEASPPRASQ DIPCLDSSAPESGTPMGALGDWPAPIEERESPAA QPLLEHQY*ATWRPLDHLLGFSNGPALLPLCWT TELSGFGLHV*TLTFGCLGQSTKTE*PRPLTLT PDLSHPQSRAWAPQMEAVSLPARP*EPNHGLVPL GACGQDHLSPWACTACRCGPLGLDLGPELWEGW FLSFLFFLFFFFFFFVLRRHQN**HYF*FW

Sequence XM_934366

GGCGCATGCGCCACTGCAGGCTGGCGGTTCGCGGCTCCTTCTTCCGGCCTCCTCCTTAGGCCGGCACCAGCAGAAGCCGGGCGAGCGCGGAGCCCCAAGC AAGTGACCTGCGACCCCGAAAGTGGACCCCAGATCCTGGGGTTCTCCCTGGTCCGGAGACTAGGGAGCTGTCGCCTGCACCCCGGGAGCACCCACCCCAC GACCACCTCTGGATGCCGCCGACGGGTACCCGGCCCGTGCCCCGCGCCTGCCTGCCGGCTCGGCCCCTCGGAGCAATTCTGGGCCAGGAGTGGGGACCCG GACCCCGCCCCTGATGCAGCCCCACCCCCGCGTCCGGGCCTTGCACCACTGACTGTCCCGGCCGGCCCCGCCCCCTGCTCGCACCCTCGCGCGGCCGAGC CCCCCTCCCCCGCTGGGGGAGGCCATGGCGTGAGCGTGAGGCCGGGCCCCGGGGCCCTCAGGCGCCAGACGGGGCATGGGCCGGGGGCCGCCCCCATGAG GGTCCCGGGAGGGGGGGCGCGGGCAGCAGCGGCGGGGCCATGGGGTCGCAGGTGTTGCAGATCCTGCGCCAGGGGGTGTGGGCCTCGCTCACCGGCGGTT GGTTCTTCGACCCGCACCAGAGCACCTTCTCCAACTGCTTCCACCTCTATGTGTGGATCTTCCTGCTCATCTTTCCCTTCTTACTGTACATGGTCCTGCC TCCCAGCTTGATGGTGGCCGGCGTGTACTGCCTCGTGGTGGCTGTCATCTTTGCTACTATCAAGACTGTCAATTATCGGCTTCATGCCATGTTTGACCAG GGCGAGATCGTGGAGAAGCGCAGCTCTACCATGGGGGAGCTGGAGGAAGAGCCTGCCCAGGGGGACAGCAATCCACCCAGGGACCCCGGAGTGGAGATGA CAGTGTTCCGGAAAGTCAGTTCCACACCCCCGGTGCGCTGCAGCTCCCAGCACTCTGTGTTTGGCTTCAACCAGGTCTCGGAGCTGCTGCCCCGAATGGA GGACTCTGGGCCCCTTAGAGACATCAAGGAGCTGGTGCGGGAGCAGGGCAGCAACAATGTGATCGTGACTTCTGCCGACCGAGAGATGCTGAAGCTCAGC TCGCAGGAGAAACTGATTGGAGACCTTCCCCAGACGCCTCCAGGGGCTGTCCCAGACCCCTCTCTTGCCAGTACAGACTCTTCAGAGCCTTCTCCCCTGG CTGGAGATGGAGCGCCCTGGAGTGGGAGCAGCATGGCTGACACTCCCATGAGCCCCCTGCTGAAGGGGAGCCTCAGCCAGGAGCTGAGCAAGAGCTTCCT GACCCTGACCCAGCCTGACCGGGCCCTGGTGAGGACCAGCAGTCGACGGGAACAACGCAGGGGGGCAGGTGGCTATCAGCCCCTTGACCGGCGGGGCTCA GGGGAGCCCACGCCCCAGAAAGCCGGCTCCTCAGACTCCTGCTTCAGCGGCACTGACAGGGAGACATTGAGCAGCTTCAAGAGTGAGAAGACCAACTCCA CCCATCTGGACAGCCCCCCAGGGGGGCCAGCCCCTGAGGGCAGCGACACAGACCCACCCTCTGAGGCTGAGCTGCCTGCCTCACCAGACGCCGGGGTCCC CTCAGATGACACGCTGCGTTCCTTTGACACGGTCATTGGAGCAGGGACGCCACCGGGCCTGGCTGAGCCGCTCCTGGTCGTGCGGCCCAAGGACTTGGCC CTGCTACGGCCTAGCAAACGGCAGCCACCCCTGCGAAGACACTCTCCACCTGGCCGTGCCCCTCGACGGCCCCTGCTTGAAGGTGGGGGCTTCTTTGAGG ATGAAGACACTAGTGAGGGCAGTGAACTGAGCCCGGCCTCCAGTCTCCGATCGCAGCGCCGCTACAGTACTGACAGCTCCTCTTCTACTTCCTGCTACTC CCCTGAGAGCTCCCGGGGTGCAGCAGGGGGACCCCGGAAGCGGAGGGCCCCCCATGGGGCTGAGGAGGGAACTGCTGTGCCCCCCAAGCGGCCATATGGG ACCCAGCGGACGCCTAGTACCGCCAGCGCTAAAACACATGCCCGTGTGCTGAGCATGGATGGGGCTGGGGGTGATGTTCTGAGGCCCCCACTGGCTGGCT GCAAGGCAGAGCTGGAGGCCCAGGTTGGGGTGGAGCAGGCTGCTAGTGAGCCTGTTGTGCTGCCTGCTGAGGCGCGAAGGGGACCCGCTGCCAACCAGCC CGGCTGGCGGGGGGAGCTGCAGGAGGAAGGTGCTGTGGGGGGAGCGGCCGAGGAGACTGGCAGGCGGGACCGCTCAAGCAGTGTGAGGCGGACCCAGGCC ATTCGGAGACGCCACAATGCAGGCAGCAACCCCACCCCTCCAGCCTCTGTCATGGGCTCGCCGCCCAGCAGCCTGCAGGAAGCTCAGCGGGGCCGGGCTG CCTCCCACTCCCGGGCGCTGACGCTGCCCTCTGCGCTGCATTTCGCCTCTTCACTGTTGCTCACCCGGGCCGGTGCCAATGTGCATGAGGCCTGCACCTT TGATGACACTTCTGAGGGTGCTGTGCACTATTTCTACGATGAGAGCGGTGTGCGGCGTTCCTACACCTTTGGCCTGGCTGGAGGCGGCTACGAGAACCCT GTAGGGCAGCAAGGGGAGCAGACAGCTAATGGAGCCTGGGACCGACACTCGCATTCCTCCAGCTTCCACTCGGCTGATGTCCCTGAGGCTACAGGCGGCC TGAACCTGCTGCAGCCGAGGCCTGTGGTTCTGCAGGGCATGCAGGTGCGCCGGGTGCCCCTGGAGATCCCGGAGGAGCAGACACTGATGGAAGAAGCGCC ACCCCGGGCCCAGCATAGTTACAAGTACTGGCTTCTCCCTGGCCGCTGGACCTCTGTGCGCTATGAGCGGCTTGCCCTGCTGGCTCTGCTGGACCGGACG CGGGGAGTGCTGGAGAACATCTTCGGCGTGGGCCTGAGCAGCCTTGTGGCCTTCCTGGGCTACCTGCTGCTGCTCAAGGGCTTCTTCACTGACATCTGGG TCTTCCAGTTCTGCCTGGTCATCGCCTCCTGCCAGTACTCCTTGCTGAAGAGCGTGCAGCCTGATGCGGCGTCCCCCATGCACGGCCACAACTGGGTGAT CGCGTACAGCCGTCCTGTCTACTTCTGCATCTGCTGTCTGCTCATCTGGCTGCTGGACGCCCTGGGCTCAGCTCAGCCCTTCCCACCTGTCTCCCTCTAC GGCCTCACGCTCTTCTCTGCCTCCTTCTTCTTCTGTGCCCGAGACGTGGCCACTGTGTTCACCCTGTGCTTCCCCTTCGTCTTCCTCCTGGGCCTCCTGC CCCAGGTCAACACCTGCCTCATGTACCTGCTGGAGCAAATAGATATGCACGGCTTCGGGGGCACAGCTGCCACCAGCCCGCTCACGGCAGTCTTCAGCCT CTCCCGCAGCCTGCTGGCTGCTGCCCTGCTCTACGGTTTCTGCCTTGGGGCCATCAAGACTCCGTGGCCAGAGCAGCACGTCCCTGTCCTCTTCTCAGTC TTCTGTGGCCTCCTGGTGGCACTGTCCTACCACCTGAGCCGGCAGAGCAGCGACCCCACCGTGCTCTGGTCTCTGATCCGGAGCAAGCTGTTCCCTGAGC TGGAGGAGCGCAGCTTGGAGACAGCCCGGGCCGAGCCCCCGGACCCCTTGCCGGACAAGATGCGCCAGTCGGTGCGTGAGGTCTTGCACTCCGACCTGGT GATGTGTGTGGTGATCGCCGTGCTCACCTTCGCCATCAGCGCCAGCACCGTCTTTATTGCCCTGAAGTCGGTGCTGGGTTTCGTGTTGTACGCACTGGCT GGGGCCGTGGGCTTCTTCACACATTACCTGCTGCCACAACTCCGCAAACAGCTGCCCTGGTTCTGCCTGTCACAGCCCGTGCTGAAGCCGCTGGAGTACA GCCAGTATGAAGTGCGCGGTGCCGCCCAGGTGATGTGGTTTGAGAAGCTGTATGCTGGCCTGCAGTGCGTAGAGAAGTACCTCATCTACCCCGCCGTGGT GCTCAACGCCCTCACGGTGGACGCCCACACAGTCGTCAGCCACCCGGACAAGTACTGCTTCTACTGCCGGGCGCTGCTGATGACCGTGGCTGGGCTGAAG CTGCTGCGCTCAGCCTTCTGCTGCCCCCCACAGCAGTACCTGACGTTGGCCTTCACCGTCCTGCTCTTCCACTTTGACTACCCGCGCCTCTCCCAGGGCT TTCTGCTTGACTACTTCCTCATGTCCCTGCTTTGCAGCAAGCTGTGGGACTTGCTGTACAAGCTGCGTTTCGTGCTGACCTACATCGCGCCCTGGCAGAT CACCTGGGGCTCGGCTTTCCACGCTTTTGCCCAGCCGTTTGCCGTGCCACACTCGGCCATGCTGTTCGTCCAGGCCCTGCTCTCGGGGCTCTTCTCCACG CCTCTCAACCCACTGCTAGGCAGTGCCGTCTTCATCATGTCCTACGCTCGGCCCCTCAAGTTCTGGGAGCGCGACTACAACACTAAACGTGTGGATCATT CCAACACCCGCCTGGTCACACAGCTGGACAGGAACCCTGGCGCTGATGACAACAACCTCAACTCCATCTTCTATGAGCACTTGACACGTTCGCTGCAGCA CACACTGTGTGGGGACCTGGTGCTGGGCCGCTGGGGCAACTATGGCCCTGGTGACTGCTTCGTCCTGGCCTCTGACTACCTCAACGCCCTGGTGCACCTC ATCGAGGTTGGCAATGGCCTCGTCACCTTCCAGCTGCGTGGCCTTGAGTTCCGGGGCACTTACTGCCAGCAGCGCGAGGTGGAGGCTATCACCGAGGGTG TGGAGGAGGACGAGGGCTGTTGCTGCTGTGAACCTGGCCACCTGCCACGGGTCCTGTCCTTCAATGCTGCCTTTGGGCAGCGCTGGCTGGCTTGGGAGGT AACAGCCAGCAAGTACGTGCTGGAGGGCTATAGCATTAGTGACAATAATGCTGCCTCCATGCTGCAGGTTTTCGACCTCCGCAAGATCCTCATCACCTAC TATGTCAAGAGCATCATCTACTACGTGAGCCGCTCACCAAAGCTGGAGGTGTGGCTCAGCCATGAGGGCATCACGGCAGCCCTGAGGCCTGTGCGGGTGC CCGGCTATGCCGACTCGGATCCCACCTTCTCGCTGAGTGTGGATGAGGACTATGACCTCCGCCTGTCTGGCCTCTCGCTGCCCTCCTTTTGTGCTGTGCA CCTCGAGTGGATCCAGTACTGCGCCTCCCGGCGCAGCCAGCCCGTGGACCAGGATTGGAACTCCCCGCTGGTCACGCTGTGTTTTGGCCTGTGTGTGCTG GGCCGCCGGGCCCTGGGGACAGCCTCTCACAGCATGTCTGCAAGCCTGGAGCCCTTCCTCTACGGCCTGCACGCCCTGTTCAAGGGGGATTTTCGCATCA CCTCCCCACGTGACGAGTGGGTCTTTGCCGACATGGACCTGCTTCACCGCGTTGTGGCGCCTGGGGTTCGCATGGCCCTCAAGCTTCACCAGGACCACTT CACGTCCCCAGATGAATATGAGGAGCCAGCAGCCCTATACGATGCCATTGCGGCCAACGAGGAGCGGCTGGTCATCTCACATGAGGGTGACCCAGCATGG CGCAGCGCCATCCTCAGCAACACGCCCTCCCTGCTGGCGCTGCGCCATGTCCTGGATGATGCCTCCGACGAGTACAAGATCATCATGCTCAACCGGCGCC ACCTCAGCTTCCGAGTCATCAAGGTGAACCGGGAGTGCGTGCGCGGCCTGTGGGCCGGGCAGCAGCAGGAGCTGGTGTTCCTGCGCAACCGCAACCCCGA GCGTGGCAGCATCCAGAACGCCAAGCAGGCGCTTCGCAACATGATCAACTCCTCCTGTGACCAGCCGCTGGGCTACCCCATCTACGTGTCGCCTCTCACC ACCTCGCTGGCTGGCAGCCACCCCCAGCTACGGGCACTGTGGGGTGGCCCCATCAGCCTGGGTGCCATTGCCCACTGGCTCCTGCGCACCTGGGAGAGGC TTCACAAGGGCTGTGGCGCCGGCTGCAATAGTGGCGGGAACGTGGATGATTCAGACTGTAGTGGGGGCGGTGGCCTGACCTCCCTCAGCAATAACCCCCC CGTGGCACACCCCACACCTGAGAACACGGCAGGCAATGGTGACCAACCCCTCCCACCAGGCCCTGGCTGGGGGCCGCGGTCCTCCCTGAGTGGCTCTGGT GATGGGCGGCCCCCACCTCTGCTGCAGTGGCCTCCCCCTCGGCTCCCTGGACCACCCCCTGCATCGCCTATCCCCACAGAGGGTCCCCGGACCTCACGGC CCCCTGGCCCGGGTCTCCTCAGTTCTGAGGGCCCCAGTGGAAAGTGGAGCCTGGGGGGCCGGAAGGGGCTGGGAGGATCTGACGGGGAGCCAGCCTCAGG GAGCCCCAAAGGAGGTACCCCCAAATCTCAGGCGCCTCTAGACCTCAGCCTCAGCCTCAGCCTCAGCCTCAGCCCCGATGTCAGCACTGAGGCCTCACCC CCCAGAGCTTCCCAGGACATTCCTTGCTTGGACAGCAGTGCCCCTGAGAGTGGCACACCTATGGGTGCCCTGGGCGACTGGCCTGCCCCTATTGAGGAGC GTGAGAGCCCGGCAGCCCAGCCCCTGCTGGAACACCAGTACTGAGCTACCTGGCGCCCACTGGACCACCTCCTAGGATTCAGTAACGGACCTGCTCTGCT GCCTCTCTGCTGGACCACAGAACTGAGTGGCTTTGGCCTACATGTCTGAACCCTGACCTTTGGCTGCCTTGGCCAGAGTACCAAAACTGAGTGACCCAGA CCTCTGACCTTGACCCCTGATCTCTCTCATCCCCAGTCCAGGGCCTGGGCTCCCCAGATGGAGGCAGTCAGCCTCCCAGCCAGGCCCTAAGAGCCAAACC ATGGGCTGGTCCCACTTGGAGCCTGTGGCCAGGACCACCTCAGCCCCTGGGCCTGCACTGCCTGCAGGTGTGGCCCCCTTGGCCTGGACCTGGGGCCTGA ATTGTGGGAAGGGTGGTTTCTTTCTTTCCTTTTTTTTCTTTTCTTTTTTTTTTTTTTTTTTGTGCTTCGGAGACATCAGAATTAATAACACTATTTTTGA TTTTGG

refseq_PCNXL3.F1 (forward primer)
refseq_PCNXL3.R1 (reverse primer)
Single exon skipping

Frame 0

GACATAGWRFAAPSSGLLLRPAPAEAGRARSPK QVTCDPESGPQILGFSLVRRLGSCRLHPGSTHPT TTSGCRRRVPGPCPAPACRLGPSEQFWARSGDP DPAPDAAPPPRPGLAPLTVPAGPAPCSHPRAAE PPSPAGGGHGVSVRPGPGALRRQTGHGPGAAPMR VPGGGARAAAAGPWGRRCCRSCARGCGPRSPAV GSSTRTRAPSPTASTSMCGSSCSSFPSYCTWSC LPA*WWPACTASWWLSSLLLSRLSIIGFMPCLTR ARSWRSAALPWGSWRKSLPRGTAIHPGTPEWR* QCSGKSVPHPRCAAAPSTLCLASTRSRSCCPEW RTLGPLETSRSWCGSRAATM*S*LLPTERC*SSA RRRN*LETFPRRLQGLSQTPLLPVQTLQSLLPW LEMERPGVGAAWLTLP*APC*RGASARS*ARAS *P*PSLTGPW*GPAVDGNNAGGQVAISPLTGGAQ GSPRPRKPAPQTPASAALTGRH*AASRVRRPTP PIWTAPQGGQPLRAATQTHPLRLSCLPHQTPGS PQMTRCVPLTRSLEQGRHRAWLSRSWSCGPRTWP CYGLANGSHPCEDTLHLAVPLDGPCLKVGASLR MKTLVRAVN*ARPPVSDRSAATVLTAPLLLPAT PLRAPGVQQGDPGSGGPPMGLRRELLCPPSGHMG PSGRLVPPALKHMPVC*AWMGLGVMF*GPHWLA ARQSWRPRLGWSRLLVSLLCCLLRREGDPLPTS PAGGGSCRRKVLWGERPRRLAGGTAQAV*GGPRP FGDATMQAATPPLQPLSWARRPAACRKLSGAGL PPTPGR*RCPLRCISPLHCCSPGPVPMCMRPAP LMTLLRVLCTISTMRAVCGVPTPLAWLEAATRTL *GSKGSRQLMEPGTDTRIPPASTRLMSLRLQAA *TCCSRGLWFCRACRCAGCPWRSRRSRH*WKKR HPGPSIVTSTGFSLAAGPLCAMSGLPCWLCWTGR GECWRTSSAWA*AALWPSWATCCCSRASSLTSG SSSSAWSSPPASTPC*RACSLMRRPPCTATTG* SRTAVLSTSASAVCSSGCWTPWAQLSPSHLSPST ASRSSLPPSSSVPETWPLCSPCASPSSSSWASC PRSTPASCTCWSK*ICTASGAQLPPARSRQSSA SPAACWLLPCSTVSALGPSRLRGQSSTSLSSSQS SVASWWHCPTT*AGRAATPPCSGL*SGASCSLS WRSAAWRQPGPSPRTPCRTRCASRCVRSCTPTW *CVW*SPCSPSPSAPAPSLLP*SRCWVSCCTHWL GPWASSHITCCHNSANSCPGSACHSPC*SRWST ASMKCAVPPR*CGLRSCMLACSA*RSTSSTPPW CSTPSRWTPTQSSATRTSTASTAGRC**PWLG*S CCAQPSAAPHSST*RWPSPSCSSTLTTRASPRA FCLTTSSCPCFAASCGTCCTSCVSC*PTSRPGR SPGARLSTLLPSRLPCHTRPCCSSRPCSRGSSPR LSTHC*AVPSSSCPTLGPSSSGSATTTLNVWII PTPAWSHSWTGTLALMTTTSTPSSMST*HVRCS THCVGTWCWAAGATMALVTASSWPLTTSTPWCTS SRLAMASSPSSCVALSSGALTASSARWRLSPRV WRRTRAVAAVNLATCHGSCPSMLPLGSAGWLGR *QPASTCWRAIALVTIMLPPCCRFSTSARSSSPT MSRASSTT*AAHQSWRCGSAMRASRQP*GLCGC PAMPTRIPPSR*VWMRTMTSACLASRCPPFVLC TSSGSSTAPPGAASPWTRIGTPRWSRCVLACVCW AAGPWGQPLTACLQAWSPSSTACTPCSRGIFAS PPHVTSGSLPTWTCFTALWRLGFAWPSSFTRTT SRPQMNMRSQQPYTMPLRPTRSGWSSHMRVTQHG AAPSSATRPPCWRCAMSWMMPPTSTRSSCSTGA TSASESSR*TGSACAACGPGSSRSWCSCATATP SVAASRTPSRRFAT*STPPVTSRWATPSTCRLSP PRWLAATPSYGHCGVAPSAWVPLPTGSCAPGRG FTRAVAPAAIVAGTWMIQTVVGAVA*PPSAITP PWHTPHLRTRQAMVTNPSHQALAGGRGPP*VALV MGGPHLCCSGLPLGSLDHPLHRLSPQRVPGPHG PLARVSSVLRAPVESGAWGAGRGWEDLTGSQPQ GAPKEVPPNLRRL*TSASASASASAPMSALRPHP PELPRTFLAWTAVPLRVAHLWVPWATGLPLLRS VRARQPSPCWNTSTELPGAHWTTS*DSVTDLLC CLSAGPQN*VALAYMSEP*PLAALARVPKLSDPD L*P*PLISLIPSPGPGLPRWRQSASQPGPKSQT MGWSHLEPVARTTSAPGPALPAGVAPLAWTWGL NCGKGGFFLSFFFFSFFFFFLCFGDIRINNTIFD F

Frame 1

AHAPLQAGGSRLLLPASSLGRHQQKPGERGAPS K*PATPKVDPRSWGSPWSGD*GAVACTPGAPTP RPPLDAADGYPARAPRLPAGSAPRSNSGPGVGTR TPPLMQPHPRVRALHH*LSRPAPPPARTLARPS PPPPLGEAMA*A*GRAPGPSGARRGMGRGPPP* GSREGGRGQQRRGHGVAGVADPAPGGVGLAHRRL VLRPAPEHLLQLLPPLCVDLPAHLSLLTVHGPA SQLDGGRRVLPRGGCHLCYYQDCQLSASCHV*P GRDRGEAQLYHGGAGGRACPGGQQSTQGPRSGDD SVPESQFHTPGALQLPALCVWLQPGLGAAAPNG GLWAP*RHQGAGAGAGQQQCDRDFCRPRDAEAQ LAGETDWRPSPDASRGCPRPLSCQYRLFRAFSPG WRWSALEWEQHG*HSHEPPAEGEPQPGAEQELP DPDPA*PGPGEDQQSTGTTQGGRWLSAP*PAGL RGAHAPESRLLRLLLQRH*QGDIEQLQE*EDQLH PSGQPPRGASP*GQRHRPTL*G*AACLTRRRGP LR*HAAFL*HGHWSRDATGPG*AAPGRAAQGLG PATA*QTAATPAKTLSTWPCPSTAPA*RWGLL*G *RH**GQ*TEPGLQSPIAAPLQY*QLLFYFLLL P*ELPGCSRGTPEAEGPPWG*GGNCCAPQAAIW DPADA*YRQR*NTCPCAEHGWGWG*CSEAPTGWL QGRAGGPGWGGAGC**ACCAAC*GAKGTRCQPA RLAGGAAGGRCCGGSGRGDWQAGPLKQCEADPG HSETPQCRQQPHPSSLCHGLAAQQPAGSSAGPGC LPLPGADAALCAAFRLFTVAHPGRCQCA*GLHL **HF*GCCALFLR*ERCAAFLHLWPGWRRLREP CRAARGADS*WSLGPTLAFLQLPLG*CP*GYRRP EPAAAEACGSAGHAGAPGAPGDPGGADTDGRSA TPGPA*LQVLASPWPLDLCAL*AACPAGSAGPD AGSAGEHLRRGPEQPCGLPGLPAAAQGLLH*HLG LPVLPGHRLLPVLLAEERAA*CGVPHARPQLGD RVQPSCLLLHLLSAHLAAGRPGLSSALPTCLPL RPHALLCLLLLLCPRRGHCVHPVLPLRLPPGPPA PGQHLPHVPAGANRYARLRGHSCHQPAHGSLQP LPQPAGCCPALRFLPWGHQDSVARAARPCPLLS LLWPPGGTVLPPEPAEQRPHRALVSDPEQAVP*A GGAQLGDSPGRAPGPLAGQDAPVGA*GLALRPG DVCGDRRAHLRHQRQHRLYCPEVGAGFRVVRTG WGRGLLHTLPAATTPQTAALVLPVTARAEAAGVQ PV*SARCRPGDVV*EAVCWPAVRREVPHLPRRG AQRPHGGRPHSRQPPGQVLLLLPGAADDRGWAE AAALSLLLPPTAVPDVGLHRPALPL*LPAPLPGL SA*LLPHVPALQQAVGLAVQAAFRADLHRALAD HLGLGFPRFCPAVCRATLGHAVRPGPALGALLH ASQPTARQCRLHHVLRSAPQVLGARLQH*TCGSF QHPPGHTAGQEPWR**QQPQLHLL*ALDTFAAA HTVWGPGAGPLGQLWPW*LLRPGL*LPQRPGAP HRGWQWPRHLPAAWP*VPGHLLPAARGGGYHRGC GGGRGLLLL*TWPPATGPVLQCCLWAALAGLGG NSQQVRAGGL*H**Q*CCLHAAGFRPPQDPHHL LCQEHHLLREPLTKAGGVAQP*GHHGSPEACAGA RLCRLGSHLLAECG*GL*PPPVWPLAALLLCCA PRVDPVLRLPAQPARGPGLELPAGHAVFWPVCA GPPGPGDSLSQHVCKPGALPLRPARPVQGGFSHH LPT*RVGLCRHGPASPRCGAWGSHGPQASPGPL HVPR*I*GASSPIRCHCGQRGAAGHLT*G*PSM AQRHPQQHALPAGAAPCPG*CLRRVQDHHAQPAP PQLPSHQGEPGVRARPVGRAAAGAGVPAQPQPR AWQHPERQAGASQHDQLLL*PAAGLPHLRVASH HLAGWQPPPATGTVGWPHQPGCHCPLAPAHLGEA SQGLWRRLQ*WRERG*FRL*WGRWPDLPQQ*PP RGTPHT*EHGRQW*PTPPTRPWLGAAVLPEWLW *WAAPTSAAVASPSAPWTTPCIAYPHRGSPDLTA PWPGSPQF*GPQWKVEPGGPEGAGRI*RGASLR EPQRRYPQISGASRPQPQPQPQPQPRCQH*GLT PQSFPGHSLLGQQCP*EWHTYGCPGRLACPY*GA *EPGSPAPAGTPVLSYLAPTGPPPRIQ*RTCSA ASLLDHRTEWLWPTCLNPDLWLPWPEYQN*VTQ TSDLDP*SLSSPVQGLGSPDGGSQPPSQALRAKP WAGPTWSLWPGPPQPLGLHCLQVWPPWPGPGA* IVGRVVSFFPFFSFLFFFFFCASETSELITLFL IL

Frame 2

RMRHCRLAVRGSFFRPPP*AGTSRSRASAEPQA SDLRPRKWTPDPGVLPGPETRELSPAPREHPPH DHLWMPPTGTRPVPRACLPARPLGAILGQEWGP GPRP*CSPTPASGPCTTDCPGRPRPLLAPSRGRA PLPRWGRPWREREAGPRGPQAPDGAWAGGRPHE GPGRGGAGSSGGAMGSQVLQILRQGVWASLTGG WFFDPHQSTFSNCFHLYVWIFLLIFPFLLYMVLP PSLMVAGVYCLVVAVIFATIKTVNYRLHAMFDQ GEIVEKRSSTMGELEEEPAQGDSNPPRDPGVEM TVFRKVSSTPPVRCSSQHSVFGFNQVSELLPRME DSGPLRDIKELVREQGSNNVIVTSADREMLKLS SQEKLIGDLPQTPPGAVPDPSLASTDSSEPSPL AGDGAPWSGSSMADTPMSPLLKGSLSQELSKSFL TLTQPDRALVRTSSRREQRRGAGGYQPLDRRGS GEPTPQKAGSSDSCFSGTDRETLSSFKSEKTNS THLDSPPGGPAPEGSDTDPPSEAELPASPDAGVP SDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDLA LLRPSKRQPPLRRHSPPGRAPRRPLLEGGGFFE DEDTSEGSELSPASSLRSQRRYSTDSSSSTSCYS PESSRGAAGGPRKRRAPHGAEEGTAVPPKRPYG TQRTPSTASAKTHARVLSMDGAGGDVLRPPLAG CKAELEAQVGVEQAASEPVVLPAEARRGPAANQP GWRGELQEEGAVGGAAEETGRRDRSSSVRRTQA IRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRA ASHSRALTLPSALHFASSLLLTRAGANVHEACTF DDTSEGAVHYFYDESGVRRSYTFGLAGGGYENP VGQQGEQTANGAWDRHSHSSSFHSADVPEATGG LNLLQPRPVVLQGMQVRRVPLEIPEEQTLMEEAP PRAQHSYKYWLLPGRWTSVRYERLALLALLDRT RGVLENIFGVGLSSLVAFLGYLLLLKGFFTDIW VFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVI AYSRPVYFCICCLLIWLLDALGSAQPFPPVSLY GLTLFSASFFFCARDVATVFTLCFPFVFLLGLL PQVNTCLMYLLEQIDMHGFGGTAATSPLTAVFSL SRSLLAAALLYGFCLGAIKTPWPEQHVPVLFSV FCGLLVALSYHLSRQSSDPTVLWSLIRSKLFPE LEERSLETARAEPPDPLPDKMRQSVREVLHSDLV MCVVIAVLTFAISASTVFIALKSVLGFVLYALA GAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEY SQYEVRGAAQVMWFEKLYAGLQCVEKYLIYPAVV LNALTVDAHTVVSHPDKYCFYCRALLMTVAGLK LLRSAFCCPPQQYLTLAFTVLLFHFDYPRLSQG FLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQI TWGSAFHAFAQPFAVPHSAMLFVQALLSGLFST PLNPLLGSAVFIMSYARPLKFWERDYNTKRVDH SNTRLVTQLDRNPGADDNNLNSIFYEHLTRSLQH TLCGDLVLGRWGNYGPGDCFVLASDYLNALVHL IEVGNGLVTFQLRGLEFRGTYCQQREVEAITEG VEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEV TASKYVLEGYSISDNNAASMLQVFDLRKILITY YVKSIIYYVSRSPKLEVWLSHEGITAALRPVRV PGYADSDPTFSLSVDEDYDLRLSGLSLPSFCAVH LEWIQYCASRRSQPVDQDWNSPLVTLCFGLCVL GRRALGTASHSMSASLEPFLYGLHALFKGDFRI TSPRDEWVFADMDLLHRVVAPGVRMALKLHQDHF TSPDEYEEPAALYDAIAANEERLVISHEGDPAW RSAILSNTPSLLALRHVLDDASDEYKIIMLNRR HLSFRVIKVNRECVRGLWAGQQQELVFLRNRNPE RGSIQNAKQALRNMINSSCDQPLGYPIYVSPLT TSLAGSHPQLRALWGGPISLGAIAHWLLRTWER LHKGCGAGCNSGGNVDDSDCSGGGGLTSLSNNPP VAHPTPENTAGNGDQPLPPGPGWGPRSSLSGSG DGRPPPLLQWPPPRLPGPPPASPIPTEGPRTSR PPGPGLLSSEGPSGKWSLGGRKGLGGSDGEPASG SPKGGTPKSQAPLDLSLSLSLSLSPDVSTEASP PRASQDIPCLDSSAPESGTPMGALGDWPAPIEE RESPAAQPLLEHQY*ATWRPLDHLLGFSNGPALL PLCWTTELSGFGLHV*TLTFGCLGQSTKTE*PR PLTLTPDLSHPQSRAWAPQMEAVSLPARP*EPN HGLVPLGACGQDHLSPWACTACRCGPLGLDLGPE LWEGWFLSFLFFLFFFFFFFVLRRHQN**HYF* FW