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Sequences

Sequence NM_138732

TGCAGGGATGCGGCGGCGGGAGCAGCCGCCCTGACTCGCGGAGCATCCTCCTCGGAGAGGCACCGCGGCGGGGCGGGCGGGCGCGAGGCGGCAGACACCG CTAGCCCTGGCTCTGCCACCCGTCGGAGACGGGGCGGCCCTGTAGCTCTGCTACCCACCCTCCAGCTTCTGGCGCCCCGAGAACCAGGCATCCCTCCCTG CTCTTCTGTCGGAGCCCGCGGCGGGGGAGGGGCGCCGCCGCCGCCGCCTGAGGGAAGCCGGCATCTGGGCCTCTGCGCGCCTCGCCCCGCGGCCGGGCCC ATGGCACTGTGAGCCTGCAAGGGAGCCCCGCTCAGCGCGGGGAGCGCCCGGCCCCCTCCCGCCCCATGCGCCCGCGGCTCTGAAGCCTGAGCGGGGGCCG GGGGCCGGGCGGGGCCGGGGCCGCCGTAGGCATGGCGTCCGGGAGCCGGTGGCGGCCGACACCGCCGCCGCTGCTGTTGCTGCTGCTGCTGGCGCTGGCG GCGCGCGCGGACGGCCTGGAGTTCGGCGGCGGCCCCGGGCAGTGGGCTCGCTACGCGCGCTGGGCGGGCGCGGCGAGCAGCGGCGAGCTCAGCTTCAGCC TGCGCACCAACGCCACGCGCGCGCTGCTGCTCTACCTGGACGACGGCGGCGACTGCGACTTCCTGGAGCTGCTGCTGGTGGACGGCCGCCTGCGGCTGCG CTTCACGCTTTCGTGCGCCGAGCCGGCCACGCTGCAGCTGGACACGCCGGTGGCCGACGACCGCTGGCACATGGTGCTGCTGACCCGCGACGCGCGCCGC ACGGCGCTGGCGGTGGACGGCGAGGCCCGCGCCGCCGAGGTGCGCTCCAAGCGGCGCGAGATGCAGGTGGCCAGCGACCTGTTCGTGGGCGGCATCCCGC CCGACGTGCGCCTCTCGGCGCTTACGCTGAGCACCGTCAAGTACGAGCCGCCCTTCCGCGGCCTCTTGGCCAACCTGAAGCTGGGCGAGCGGCCCCCCGC GCTGCTGGGCAGCCAGGGCCTGCGCGGCGCCACCGCCGACCCGCTGTGCGCGCCCGCGCGCAACCCCTGCGCCAACGGCGGCCTCTGCACCGTGCTGGCC CCCGGCGAGGTGGGCTGCGACTGCAGCCACACGGGCTTCGGCGGCAAGTTCTGCAGCGAAGAGGAGCACCCCATGGAAGGTCCGGCTCACCTGACGTTAA ACAGCGAAGGCAAGGAGGAGTTTGTGGCGACCTTCAAAGGCAATGAGTTCTTCTGCTACGACCTGTCACACAACCCCATCCAGAGCAGCACTGATGAGAT CACACTGGCCTTCCGCACCCTGCAACGCAACGGCCTGATGCTGCATACAGGCAAGTCGGCCGACTACGTCAACCTGTCCCTCAAGTCTGGGGCTGTCTGG CTGGTCATCAACCTAGGCTCAGGTGCCTTCGAGGCCCTTGTGGAACCCGTCAATGGCAAGTTCAACGACAACGCCTGGCACGACGTCCGGGTCACCCGAA ACCTGCGCCAGCACGCAGGGATTGGACACGCTATGGTGACCATCTCGGTGGACGGGATCCTGACCACCACAGGCTACACGCAGGAGGATTACACCATGCT GGGCTCTGATGACTTCTTCTACATTGGGGGCAGCCCCAACACAGCTGACCTGCCGGGCTCGCCCGTCAGCAACAACTTCATGGGCTGCCTCAAGGACGTG GTCTATAAGAACAATGACTTCAAATTGGAACTATCCCGCCTGGCAAAGGAAGGGGACCCCAAGATGAAGCTGCAGGGGGACTTGTCATTCCGCTGTGAGG ATGTGGCTGCCCTGGACCCTGTGACCTTTGAGAGTCCCGAGGCCTTTGTGGCGCTGCCCCGCTGGAGCGCTAAGCGCACTGGCTCCATCTCCCTAGACTT CCGCACCACCGAGCCCAATGGGCTGCTGCTCTTCAGCCAGGGCCGGCGGGCTGGGGGTGGAGCTGGCAGCCACAGCTCTGCTCAGCGGGCCGACTACTTT GCCATGGAGCTATTGGACGGCCACCTCTATCTTCTGCTGGACATGGGATCTGGGGGCATCAAGCTGCGGGCATCCAGCCGCAAGGTCAATGATGGCGAGT GGTGTCACGTGGACTTCCAGAGGGATGGGCGAAAAGGCTCCATCTCAGTGAATAGTCGCAGCACGCCGTTCTTGGCCACTGGAGACAGCGAGATTCTGGA CCTGGAGAGTGAGCTGTACCTGGGCGGTCTCCCTGAGGGGGGCCGGGTGGACCTGCCCCTGCCCCCAGAGGTGTGGACAGCAGCACTCCGGGCAGGCTAC GTGGGCTGTGTGCGGGACCTCTTCATAGATGGGCGTAGCCGAGACCTCCGGGGCCTGGCTGAGGCTCAGGGGGCTGTGGGCGTTGCCCCCTTTTGCTCCC GGGAGACGCTGAAGCAGTGTGCATCTGCCCCCTGTCGCAATGGGGGCGTCTGTCGAGAAGGCTGGAACCGCTTCATCTGTGACTGCATCGGGACCGGCTT TCTTGGGCGGGTCTGTGAGAGAGAGGCCACGGTCCTGAGCTACGATGGCTCCATGTACATGAAGATCATGCTGCCTAACGCCATGCACACGGAGGCAGAG GATGTGTCCCTGCGTTTCATGTCCCAGCGGGCCTACGGACTCATGATGGCCACCACTTCCAGGGAGTCTGCCGACACCCTACGCCTGGAGCTGGATGGGG GGCAGATGAAGCTCACTGTCAACCTCGGTAAAGGCCCCGAAACGCTGTTTGCGGGGCACAAGCTCAATGACAATGAGTGGCACACGGTGAGGGTGGTCCG GCGTGGCAAGAGCCTGCAGCTGTCTGTGGACAACGTGACTGTGGAGGGACAGATGGCAGGAGCCCATATGCGGCTGGAGTTCCACAACATTGAGACGGGC ATCATGACGGAGCGGCGGTTTATCTCCGTGGTGCCCTCCAACTTCATCGGGCATCTGAGTGGGCTCGTGTTCAATGGCCAGCCCTACATGGACCAGTGCA AGGATGGTGACATCACCTACTGTGAGCTCAATGCTCGCTTTGGCCTGCGTGCCATCGTGGCCGATCCCGTCACCTTCAAGAGTCGCAGCAGCTACCTGGC ACTCGCCACGCTCCAAGCCTATGCTTCCATGCACCTCTTCTTCCAGTTCAAGACCACGGCCCCTGATGGGCTTCTTCTGTTCAACTCGGGCAACGGCAAT GACTTCATTGTCATCGAGCTGGTCAAGGGGTACATCCACTACGTGTTTGACCTGGGGAATGGCCCGTCCTTGATGAAGGGGAACTCAGACAAACCAGTCA ATGACAACCAGTGGCACAACGTGGTGGTGTCCAGGGACCCAGGCAACGTGCACACGCTCAAGATTGACTCCCGCACTGTCACGCAGCACTCCAATGGCGC CCGAAACCTCGATCTCAAAGGGGAGTTGTACATTGGCGGTCTGAGCAAGAATATGTTCAGCAACCTGCCCAAGCTGGTGGCCTCCCGGGATGGCTTTCAG GGCTGCCTGGCCTCAGTGGACCTCAACGGACGTCTCCCAGACCTCATCGCCGACGCCCTGCACCGCATTGGGCAGGTGGAGAGGGGCTGTGATGGCCCCA GCACCACCTGCACTGAAGAGTCCTGTGCCAACCAGGGCGTCTGCTTGCAGCAGTGGGATGGCTTCACCTGCGACTGCACCATGACTTCCTATGGAGGCCC TGTCTGCAATGATCCCGGGACCACATACATCTTTGGGAAGGGGGGAGCGCTCATCACCTACACGTGGCCCCCCAATGACAGGCCCAGCACGAGGATGGAT CGCCTGGCCGTGGGCTTCAGCACCCACCAGCGGAGCGCTGTGCTGGTGCGGGTGGACAGCGCCTCCGGCCTTGGAGACTACCTGCAGCTGCACATCGACC AGGGCACCGTGGGGGTGATCTTTAACGTGGGCACGGACGACATTACCATCGACGAGCCCAACGCCATAGTAAGCGACGGCAAATACCACGTGGTGCGCTT CACTCGAAGCGGCGGCAACGCCACCCTGCAGGTGGACAGCTGGCCGGTCAACGAGCGGTACCCGGCAGGCCGCCAGCTGACCATCTTCAACAGCCAGGCT GCCATCAAGATCGGGGGCCGGGATCAGGGCCGCCCCTTCCAGGGCCAGGTGTCCGGCCTCTACTACAATGGGCTCAAGGTGCTGGCGCTGGCCGCCGAGA GCGACCCCAATGTGCGGACTGAGGGTCACCTGCGCCTGGTGGGGGAGGGGCCGTCCGTGCTGCTCAGTGCGGAGACCACGGCCACCACCCTGCTGGCTGA CATGGCCACCACCATCATGGAGACTACCACCACCATGGCCACTACCACCACGCGCCGGGGCCGCTCCCCCACACTGAGGGACAGCACCACCCAGAACACA GATGACCTGCTGGTGGCCTCTGCTGAGTGTCCAAGCGATGATGAGGACCTGGAGGAGTGTGAGCCCAGTACTGGAGGAGAGTTAATATTGCCCATTATCA CGGAGGACTCCTTAGACCCCCCTCCCGTGGCCACCCGATCCCCCTTCGTGCCCCCGCCCCCTACCTTCTACCCCTTCCTCACGGGAGTGGGCGCCACCCA AGACACGCTGCCCCCGCCCGCCGCGCGCCGCCCGCCCTCTGGGGGCCCGTGCCAGGCCGAGCGGGACGACAGCGACTGCGAGGAGCCCATCGAGGCCTCG GGCTTCGCCTCCGGGGAGGTCTTTGACTCCAGCCTCCCCCCCACGGACGACGAGGACTTTTACACCACCTTTCCCCTGGTCACGGACCGCACCACCCTCC TGTCACCCCGCAAACCCGCTCCCCGGCCCAACCTCAGGACAGATGGGGCCACGGGCGCCCCTGGGGTGCTGTTTGCCCCCTCCGCCCCGGCCCCCAACCT GCCGGCGGGCAAAATGAACCACCGAGACCCGCTTCAGCCCTTGCTGGAGAACCCGCCCTTGGGGCCCGGGGCCCCCACGTCCTTTGAGCCGCGGAGGCCC CCTCCCCTGCGCCCCGGCGTGACCTCAGCCCCCGGCTTCCCCCATCTGCCCACAGCCAACCCCACAGGGCCTGGGGAGCGGGGCCCGCCGGGCGCAGTGG AGGTGATCCGGGAGTCCAGCAGCACCACGGGCATGGTGGTGGGCATTGTGGCGGCGGCGGCGCTCTGCATCCTCATCCTCCTCTACGCCATGTATAAGTA CCGCAATCGTGATGAGGGCTCCTACCAGGTGGACCAGAGCCGAAACTACATCAGTAACTCGGCCCAGAGCAATGGGGCGGTGGTGAAAGAGAAGGCCCCG GCTGCCCCCAAGACGCCCAGCAAGGCCAAGAAGAACAAAGACAAGGAGTATTATGTCTGAGCCCCCGGCACTGCGCCCCACTGCCAGCTGCCCCTCCTGG GAGGGCCCGGGAGGAGGGTGCCACCCTCTCCCTGCCAGGGGCCTGGGGACCCTCTCCCTGGCTGCCTCAGGCTTCTCTTACGAAGAGGAAACGCAAAAAA AGAAAAGGAAAAACCCCGTGCTCGCCCCCTTCCTCCTGCCGTCCACTGCGCGGCCTCGTCAGTCCCGGGGCTGACTGTCCCTCTCAGCTCTGCGCCTGCC AGGCAGGGCACGTGCTCACAGCCCTGGGTTGATTTATTTTTTTAAGGGGGTAGTTTTATTTTGGTGGGGTTGGGTGGGAAGGAAGGCTGGGGGTTTTGTA AAGTGTCCACTGCTCGTCCTGTTAATTTTCCTCAATTTTTCTTCTTCTTCCTTCTGTCCCTCCTGCCTTCCTTCTCTTCCCAAGCCCTCCAATCCCCATC CCAGGCTTGCTGTGTCTCACTGTCCCCACCCTCCTTCCCTACTTCTTTTTTTGTGTGTCTGGTTTCTCCCTTCCTTTCCTCCCTTTGGGTTTCCAGAGTC GGTGGGAGAAGGGCGGGAGGGTGGGCCCGAGTGGCCCAGTGGGTGGGTGGGGTGGGGTGGGGCAAGTGCCCCAACTCCCCTCACCAGGAGAGGCACCTGC TTGGTGCCGCCCAGGGAAGGGGCTCAGGCCTGACGGAAGGCCTGTTCTGTGTGTGCCGCCGGGCGACGTGCATTGATGGGGAAGCTGCTGGAGGAGCAGG GGTGGGGGGTGGGAGGGAGGGGAAAGGCAAATGCAGATATATATTACAGACAAATACTCTAGATTCCACGAGCAGCAGCCTGTGGCACCCGCTGGGCGCG GGCAGCAGGGAAGAGGGAGCAAGGCATTGTCCACAGACTGCTGGGGTCACTTCTTTGCCCACGGGCTCCCTGCTCCCCCAGTTTTTTTTCTCTCTTTGTT AACAAATGTGTCTGAGTCTTGGAAAACACCCCAACCCCGGAAATGTGTGGGAAAAAGAAAACAAAAACTTTCCAAATTCCAA

refseq_NRXN2.F3 (forward primer)
refseq_NRXN2.R3 (reverse primer)
Single exon skipping

Frame 0

CRDAAAGAAALTRGASSSERHRGGAGGREAADT ASPGSATRRRRGGPVALLPTLQLLAPREPGIPPC SSVGARGGGGAPPPPPEGSRHLGLCAPRPAAGP MAL*ACKGAPLSAGSARPPPAPCARGSEA*AGA GGRAGPGPP*AWRPGAGGGRHRRRCCCCCCWRWR RARTAWSSAAAPGSGLATRAGRARRAAASSASA CAPTPRARCCSTWTTAATATSWSCCWWTAACGC ASRFRAPSRPRCSWTRRWPTTAGTWCC*PATRAA RRWRWTARPAPPRCAPSGARCRWPATCSWAASR PTCASRRLR*APSSTSRPSAASWPT*SWASGPP RCWAARACAAPPPTRCARPRATPAPTAASAPCWP PARWAATAATRASAASSAAKRSTPWKVRLT*R* TAKARRSLWRPSKAMSSSATTCHTTPSRAALMR SHWPSAPCNATA*CCIQASRPTTSTCPSSLGLSG WSST*AQVPSRPLWNPSMASSTTTPGTTSGSPE TCASTQGLDTLW*PSRWTGS*PPQATRRRITPC WALMTSSTLGAAPTQLTCRARPSATTSWAASRTW SIRTMTSNWNYPAWQRKGTPR*SCRGTCHSAVR MWLPWTL*PLRVPRPLWRCPAGALSALAPSP*T SAPPSPMGCCSSARAGGLGVELAATALLSGPTTL PWSYWTATSIFCWTWDLGASSCGHPAARSMMAS GVTWTSRGMGEKAPSQ*IVAARRSWPLETARFW TWRVSCTWAVSLRGAGWTCPCPQRCGQQHSGQAT WAVCGTSS*MGVAETSGAWLRLRGLWALPPFAP GRR*SSVHLPPVAMGASVEKAGTASSVTASGPA FLGGSVRERPRS*ATMAPCT*RSCCLTPCTRRQR MCPCVSCPSGPTDS*WPPLPGSLPTPYAWSWMG GR*SSLSTSVKAPKRCLRGTSSMTMSGTR*GWS GVARACSCLWTT*LWRDRWQEPICGWSSTTLRRA S*RSGGLSPWCPPTSSGI*VGSCSMASPTWTSA RMVTSPTVSSMLALACVPSWPIPSPSRVAAATW HSPRSKPMLPCTSSSSSRPRPLMGFFCSTRATAM TSLSSSWSRGTSTTCLTWGMARP**RGTQTNQS MTTSGTTWWCPGTQATCTRSRLTPALSRSTPMA PETSISKGSCTLAV*ARICSATCPSWWPPGMAFR AAWPQWTSTDVSQTSSPTPCTALGRWRGAVMAP APPALKSPVPTRASACSSGMASPATAP*LPMEA LSAMIPGPHTSLGRGERSSPTRGPPMTGPARGWI AWPWASAPTSGALCWCGWTAPPALETTCSCTST RAPWG*SLTWARTTLPSTSPTP**ATANTTWCA SLEAAATPPCRWTAGRSTSGTRQAAS*PSSTARL PSRSGAGIRAAPSRARCPASTTMGSRCWRWPPR ATPMCGLRVTCAWWGRGRPCCSVRRPRPPPCWL TWPPPSWRLPPPWPLPPRAGAAPPH*GTAPPRTQ MTCWWPLLSVQAMMRTWRSVSPVLEES*YCPLS RRTP*TPLPWPPDPPSCPRPLPSTPSSREWAPP KTRCPRPPRAARPLGARARPSGTTATARSPSRPR ASPPGRSLTPASPPRTTRTFTPPFPWSRTAPPS CHPANPLPGPTSGQMGPRAPLGCCLPPPPRPPT CRRAK*TTETRFSPCWRTRPWGPGPPRPLSRGGP LPCAPA*PQPPASPICPQPTPQGLGSGARRAQW R*SGSPAAPRAWWWALWRRRRSASSSSSTPCIS TAIVMRAPTRWTRAETTSVTRPRAMGRW*KRRPR LPPRRPARPRRTKTRSIMSEPPALRPTASCPSW EGPGGGCHPLPARGLGTLSLAASGFSYEEETQK KKRKNPVLAPFLLPSTARPRQSRG*LSLSALRLP GRARAHSPGLIYFFKGVVLFWWGWVGRKAGGFV KCPLLVLLIFLNFSSSSFCPSCLPSLPKPSNPH PRLAVSHCPHPPSLLLFLCVWFLPSFPPFGFPES VGEGREGGPEWPSGWVGWGGASAPTPLTRRGTC LVPPREGAQA*RKACSVCAAGRRALMGKLLEEQ GWGVGGRGKANADIYYRQIL*IPRAAACGTRWAR AAGKREQGIVHRLLGSLLCPRAPCSPSFFSLFV NKCV*VLENTPTPEMCGKKKTKTFQIP

Frame 1

AGMRRREQPP*LAEHPPRRGTAAGRAGARRQTP LALALPPVGDGAAL*LCYPPSSFWRPENQASLP ALLSEPAAGEGRRRRRLREAGIWASARLAPRPGP WHCEPAREPRSARGAPGPLPPHAPAALKPERGP GAGRGRGRRRHGVREPVAADTAAAAVAAAAGAG GARGRPGVRRRPRAVGSLRALGGRGEQRRAQLQP AHQRHARAAALPGRRRRLRLPGAAAGGRPPAAA LHAFVRRAGHAAAGHAGGRRPLAHGAADPRRAP HGAGGGRRGPRRRGALQAARDAGGQRPVRGRHPA RRAPLGAYAEHRQVRAALPRPLGQPEAGRAAPR AAGQPGPARRHRRPAVRARAQPLRQRRPLHRAG PRRGGLRLQPHGLRRQVLQRRGAPHGRSGSPDVK QRRQGGVCGDLQRQ*VLLLRPVTQPHPEQH**D HTGLPHPATQRPDAAYRQVGRLRQPVPQVWGCL AGHQPRLRCLRGPCGTRQWQVQRQRLARRPGHPK PAPARRDWTRYGDHLGGRDPDHHRLHAGGLHHA GL**LLLHWGQPQHS*PAGLARQQQLHGLPQGR GL*EQ*LQIGTIPPGKGRGPQDEAAGGLVIPL*G CGCPGPCDL*ESRGLCGAAPLER*AHWLHLPRL PHHRAQWAAALQPGPAGWGWSWQPQLCSAGRLL CHGAIGRPPLSSAGHGIWGHQAAGIQPQGQ*WRV VSRGLPEGWAKRLHLSE*SQHAVLGHWRQRDSG PGE*AVPGRSP*GGPGGPAPAPRGVDSSTPGRL RGLCAGPLHRWA*PRPPGPG*GSGGCGRCPLLLP GDAEAVCICPLSQWGRLSRRLEPLHL*LHRDRL SWAGL*ERGHGPELRWLHVHEDHAA*RHAHGGR GCVPAFHVPAGLRTHDGHHFQGVCRHPTPGAGWG ADEAHCQPR*RPRNAVCGAQAQ*Q*VAHGEGGP AWQEPAAVCGQRDCGGTDGRSPYAAGVPQH*DG HHDGAAVYLRGALQLHRASEWARVQWPALHGPVQ GW*HHLL*AQCSLWPACHRGRSRHLQESQQLPG TRHAPSLCFHAPLLPVQDHGP*WASSVQLGQRQ *LHCHRAGQGVHPLRV*PGEWPVLDEGELRQTSQ *QPVAQRGGVQGPRQRAHAQD*LPHCHAALQWR PKPRSQRGVVHWRSEQEYVQQPAQAGGLPGWLS GLPGLSGPQRTSPRPHRRRPAPHWAGGEGL*WPQ HHLH*RVLCQPGRLLAAVGWLHLRLHHDFLWRP CLQ*SRDHIHLWEGGSAHHLHVAPQ*QAQHEDG SPGRGLQHPPAERCAGAGGQRLRPWRLPAAAHRP GHRGGDL*RGHGRHYHRRAQRHSKRRQIPRGAL HSKRRQRHPAGGQLAGQRAVPGRPPADHLQQPG CHQDRGPGSGPPLPGPGVRPLLQWAQGAGAGRRE RPQCAD*GSPAPGGGGAVRAAQCGDHGHHPAG* HGHHHHGDYHHHGHYHHAPGPLPHTEGQHHPEH R*PAGGLC*VSKR**GPGGV*AQYWRRVNIAHYH GGLLRPPSRGHPIPLRAPAPYLLPLPHGSGRHP RHAAPARRAPPALWGPVPGRAGRQRLRGAHRGL GLRLRGGL*LQPPPHGRRGLLHHLSPGHGPHHPP VTPQTRSPAQPQDRWGHGRPWGAVCPLRPGPQP AGGQNEPPRPASALAGEPALGARGPHVL*AAEA PSPAPRRDLSPRLPPSAHSQPHRAWGAGPAGRSG GDPGVQQHHGHGGGHCGGGGALHPHPPLRHV*V PQS**GLLPGGPEPKLHQ*LGPEQWGGGEREGP GCPQDAQQGQEEQRQGVLCLSPRHCAPLPAAPPG RAREEGATLSLPGAWGPSPWLPQASLTKRKRKK RKGKTPCSPPSSCRPLRGLVSPGADCPSQLCAC QAGHVLTALG*FIFLRG*FYFGGVGWEGRLGVL* SVHCSSC*FSSIFLLLPSVPPAFLLFPSPPIPI PGLLCLTVPTLLPYFFFCVSGFSLPFLPLGFQS RWEKGGRVGPSGPVGGWGGVGQVPQLPSPGEAPA WCRPGKGLRPDGRPVLCVPPGDVH*WGSCWRSR GGGWEGGERQMQIYITDKYSRFHEQQPVAPAGR GQQGRGSKALSTDCWGHFFAHGLPAPPVFFLSLL TNVSESWKTPQPRKCVGKRKQKLSKFQ

Frame 2

QGCGGGSSRPDSRSILLGEAPRRGGRARGGRHR *PWLCHPSETGRPCSSATHPPASGAPRTRHPSL LFCRSPRRGRGAAAAA*GKPASGPLRASPRGRA HGTVSLQGSPAQRGERPAPSRPMRPRL*SLSGGR GPGGAGAAVGMASGSRWRPTPPPLLLLLLLALA ARADGLEFGGGPGQWARYARWAGAASSGELSFS LRTNATRALLLYLDDGGDCDFLELLLVDGRLRLR FTLSCAEPATLQLDTPVADDRWHMVLLTRDARR TALAVDGEARAAEVRSKRREMQVASDLFVGGIP PDVRLSALTLSTVKYEPPFRGLLANLKLGERPPA LLGSQGLRGATADPLCAPARNPCANGGLCTVLA PGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTL NSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEI TLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVW LVINLGSGAFEALVEPVNGKFNDNAWHDVRVTR NLRQHAGIGHAMVTISVDGILTTTGYTQEDYTML GSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDV VYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCE DVAALDPVTFESPEAFVALPRWSAKRTGSISLDF RTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF AMELLDGHLYLLLDMGSGGIKLRASSRKVNDGE WCHVDFQRDGRKGSISVNSRSTPFLATGDSEILD LESELYLGGLPEGGRVDLPLPPEVWTAALRAGY VGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCS RETLKQCASAPCRNGGVCREGWNRFICDCIGTGF LGRVCEREATVLSYDGSMYMKIMLPNAMHTEAE DVSLRFMSQRAYGLMMATTSRESADTLRLELDG GQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVR RGKSLQLSVDNVTVEGQMAGAHMRLEFHNIETG IMTERRFISVVPSNFIGHLSGLVFNGQPYMDQC KDGDITYCELNARFGLRAIVADPVTFKSRSSYLA LATLQAYASMHLFFQFKTTAPDGLLLFNSGNGN DFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA RNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQ GCLASVDLNGRLPDLIADALHRIGQVERGCDGP STTCTEESCANQGVCLQQWDGFTCDCTMTSYGGP VCNDPGTTYIFGKGGALITYTWPPNDRPSTRMD RLAVGFSTHQRSAVLVRVDSASGLGDYLQLHID QGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRF TRSGGNATLQVDSWPVNERYPAGRQLTIFNSQA AIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAE SDPNVRTEGHLRLVGEGPSVLLSAETTATTLLAD MATTIMETTTTMATTTTRRGRSPTLRDSTTQNT DDLLVASAECPSDDEDLEECEPSTGGELILPII TEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQ DTLPPPAARRPPSGGPCQAERDDSDCEEPIEAS GFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTL LSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRP PPLRPGVTSAPGFPHLPTANPTGPGERGPPGAV EVIRESSSTTGMVVGIVAAAALCILILLYAMYKY RNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAP AAPKTPSKAKKNKDKEYYV*APGTAPHCQLPLL GGPGRRVPPSPCQGPGDPLPGCLRLLLRRGNAKK EKEKPRARPLPPAVHCAASSVPGLTVPLSSAPA RQGTCSQPWVDLFF*GGSFILVGLGGKEGWGFC KVSTARPVNFPQFFFFFLLSLLPSFSSQALQSPS QACCVSLSPPSFPTSFFVCLVSPFLSSLWVSRV GGRRAGGWARVAQWVGGVGWGKCPNSPHQERHL LGAAQGRGSGLTEGLFCVCRRATCIDGEAAGGAG VGGGREGKGKCRYILQTNTLDSTSSSLWHPLGA GSREEGARHCPQTAGVTSLPTGSLLPQFFFSLC *QMCLSLGKHPNPGNVWEKENKNFPNS

Sequence NM_015080

TGCAGGGATGCGGCGGCGGGAGCAGCCGCCCTGACTCGCGGAGCATCCTCCTCGGAGAGGCACCGCGGCGGGGCGGGCGGGCGCGAGGCGGCAGACACCG CTAGCCCTGGCTCTGCCACCCGTCGGAGACGGGGCGGCCCTGTAGCTCTGCTACCCACCCTCCAGCTTCTGGCGCCCCGAGAACCAGGCATCCCTCCCTG CTCTTCTGTCGGAGCCCGCGGCGGGGGAGGGGCGCCGCCGCCGCCGCCTGAGGGAAGCCGGCATCTGGGCCTCTGCGCGCCTCGCCCCGCGGCCGGGCCC ATGGCACTGTGAGCCTGCAAGGGAGCCCCGCTCAGCGCGGGGAGCGCCCGGCCCCCTCCCGCCCCATGCGCCCGCGGCTCTGAAGCCTGAGCGGGGGCCG GGGGCCGGGCGGGGCCGGGGCCGCCGTAGGCATGGCGTCCGGGAGCCGGTGGCGGCCGACACCGCCGCCGCTGCTGTTGCTGCTGCTGCTGGCGCTGGCG GCGCGCGCGGACGGCCTGGAGTTCGGCGGCGGCCCCGGGCAGTGGGCTCGCTACGCGCGCTGGGCGGGCGCGGCGAGCAGCGGCGAGCTCAGCTTCAGCC TGCGCACCAACGCCACGCGCGCGCTGCTGCTCTACCTGGACGACGGCGGCGACTGCGACTTCCTGGAGCTGCTGCTGGTGGACGGCCGCCTGCGGCTGCG CTTCACGCTTTCGTGCGCCGAGCCGGCCACGCTGCAGCTGGACACGCCGGTGGCCGACGACCGCTGGCACATGGTGCTGCTGACCCGCGACGCGCGCCGC ACGGCGCTGGCGGTGGACGGCGAGGCCCGCGCCGCCGAGGTGCGCTCCAAGCGGCGCGAGATGCAGGTGGCCAGCGACCTGTTCGTGGGCGGCATCCCGC CCGACGTGCGCCTCTCGGCGCTTACGCTGAGCACCGTCAAGTACGAGCCGCCCTTCCGCGGCCTCTTGGCCAACCTGAAGCTGGGCGAGCGGCCCCCCGC GCTGCTGGGCAGCCAGGGCCTGCGCGGCGCCACCGCCGACCCGCTGTGCGCGCCCGCGCGCAACCCCTGCGCCAACGGCGGCCTCTGCACCGTGCTGGCC CCCGGCGAGGTGGGCTGCGACTGCAGCCACACGGGCTTCGGCGGCAAGTTCTGCAGCGAAGAGGAGCACCCCATGGAAGGTCCGGCTCACCTGACGTTAA ACAGCGAAGTAGGGTCCTTACTGTTCTCCGAGGGGGGGGCCGGGAGAGGAGGAGCCGGCGATGTGCACCAGCCAACAAAAGGCAAGGAGGAGTTTGTGGC GACCTTCAAAGGCAATGAGTTCTTCTGCTACGACCTGTCACACAACCCCATCCAGAGCAGCACTGATGAGATCACACTGGCCTTCCGCACCCTGCAACGC AACGGCCTGATGCTGCATACAGGCAAGTCGGCCGACTACGTCAACCTGTCCCTCAAGTCTGGGGCTGTCTGGCTGGTCATCAACCTAGGCTCAGGTGCCT TCGAGGCCCTTGTGGAACCCGTCAATGGCAAGTTCAACGACAACGCCTGGCACGACGTCCGGGTCACCCGAAACCTGCGCCAGCACGCAGGGATTGGACA CGCTATGGTAAACAAACTGCATTATCTGGTGACCATCTCGGTGGACGGGATCCTGACCACCACAGGCTACACGCAGGAGGATTACACCATGCTGGGCTCT GATGACTTCTTCTACATTGGGGGCAGCCCCAACACAGCTGACCTGCCGGGCTCGCCCGTCAGCAACAACTTCATGGGCTGCCTCAAGGACGTGGTCTATA AGAACAATGACTTCAAATTGGAACTATCCCGCCTGGCAAAGGAAGGGGACCCCAAGATGAAGCTGCAGGGGGACTTGTCATTCCGCTGTGAGGATGTGGC TGCCCTGGACCCTGTGACCTTTGAGAGTCCCGAGGCCTTTGTGGCGCTGCCCCGCTGGAGCGCTAAGCGCACTGGCTCCATCTCCCTAGACTTCCGCACC ACCGAGCCCAATGGGCTGCTGCTCTTCAGCCAGGGCCGGCGGGCTGGGGGTGGAGCTGGCAGCCACAGCTCTGCTCAGCGGGCCGACTACTTTGCCATGG AGCTATTGGACGGCCACCTCTATCTTCTGCTGGACATGGGATCTGGGGGCATCAAGCTGCGGGCATCCAGCCGCAAGGTCAATGATGGCGAGTGGTGTCA CGTGGACTTCCAGAGGGATGGGCGAAAAGGCTCCATCTCAGTGAATAGTCGCAGCACGCCGTTCTTGGCCACTGGAGACAGCGAGATTCTGGACCTGGAG AGTGAGCTGTACCTGGGCGGTCTCCCTGAGGGGGGCCGGGTGGACCTGCCCCTGCCCCCAGAGGTGTGGACAGCAGCACTCCGGGCAGGCTACGTGGGCT GTGTGCGGGACCTCTTCATAGATGGGCGTAGCCGAGACCTCCGGGGCCTGGCTGAGGCTCAGGGGGCTGTGGGCGTTGCCCCCTTTTGCTCCCGGGAGAC GCTGAAGCAGTGTGCATCTGCCCCCTGTCGCAATGGGGGCGTCTGTCGAGAAGGCTGGAACCGCTTCATCTGTGACTGCATCGGGACCGGCTTTCTTGGG CGGGTCTGTGAGAGAGAGGCCACGGTCCTGAGCTACGATGGCTCCATGTACATGAAGATCATGCTGCCTAACGCCATGCACACGGAGGCAGAGGATGTGT CCCTGCGTTTCATGTCCCAGCGGGCCTACGGACTCATGATGGCCACCACTTCCAGGGAGTCTGCCGACACCCTACGCCTGGAGCTGGATGGGGGGCAGAT GAAGCTCACTGTCAACCTCGACTGCCTGCGCGTCGGCTGCGCACCCAGTAAAGGCCCCGAAACGCTGTTTGCGGGGCACAAGCTCAATGACAATGAGTGG CACACGGTGAGGGTGGTCCGGCGTGGCAAGAGCCTGCAGCTGTCTGTGGACAACGTGACTGTGGAGGGACAGATGGCAGGAGCCCATATGCGGCTGGAGT TCCACAACATTGAGACGGGCATCATGACGGAGCGGCGGTTTATCTCCGTGGTGCCCTCCAACTTCATCGGGCATCTGAGTGGGCTCGTGTTCAATGGCCA GCCCTACATGGACCAGTGCAAGGATGGTGACATCACCTACTGTGAGCTCAATGCTCGCTTTGGCCTGCGTGCCATCGTGGCCGATCCCGTCACCTTCAAG AGTCGCAGCAGCTACCTGGCACTCGCCACGCTCCAAGCCTATGCTTCCATGCACCTCTTCTTCCAGTTCAAGACCACGGCCCCTGATGGGCTTCTTCTGT TCAACTCGGGCAACGGCAATGACTTCATTGTCATCGAGCTGGTCAAGGGGTACATCCACTACGTGTTTGACCTGGGGAATGGCCCGTCCTTGATGAAGGG GAACTCAGACAAACCAGTCAATGACAACCAGTGGCACAACGTGGTGGTGTCCAGGGACCCAGGCAACGTGCACACGCTCAAGATTGACTCCCGCACTGTC ACGCAGCACTCCAATGGCGCCCGAAACCTCGATCTCAAAGGGGAGTTGTACATTGGCGGTCTGAGCAAGAATATGTTCAGCAACCTGCCCAAGCTGGTGG CCTCCCGGGATGGCTTTCAGGGCTGCCTGGCCTCAGTGGACCTCAACGGACGTCTCCCAGACCTCATCGCCGACGCCCTGCACCGCATTGGGCAGGTGGA GAGGGGCTGTGATGGCCCCAGCACCACCTGCACTGAAGAGTCCTGTGCCAACCAGGGCGTCTGCTTGCAGCAGTGGGATGGCTTCACCTGCGACTGCACC ATGACTTCCTATGGAGGCCCTGTCTGCAATGATCCCGGGACCACATACATCTTTGGGAAGGGGGGAGCGCTCATCACCTACACGTGGCCCCCCAATGACA GGCCCAGCACGAGGATGGATCGCCTGGCCGTGGGCTTCAGCACCCACCAGCGGAGCGCTGTGCTGGTGCGGGTGGACAGCGCCTCCGGCCTTGGAGACTA CCTGCAGCTGCACATCGACCAGGGCACCGTGGGGGTGATCTTTAACGTGGGCACGGACGACATTACCATCGACGAGCCCAACGCCATAGTAAGCGACGGC AAATACCACGTGGTGCGCTTCACTCGAAGCGGCGGCAACGCCACCCTGCAGGTGGACAGCTGGCCGGTCAACGAGCGGTACCCGGCAGGAAACTTTGATA ACGAGCGCCTGGCGATTGCTAGACAGAGAATCCCCTACCGGCTTGGTCGAGTAGTAGATGAGTGGCTGCTCGACAAAGGCCGCCAGCTGACCATCTTCAA CAGCCAGGCTGCCATCAAGATCGGGGGCCGGGATCAGGGCCGCCCCTTCCAGGGCCAGGTGTCCGGCCTCTACTACAATGGGCTCAAGGTGCTGGCGCTG GCCGCCGAGAGCGACCCCAATGTGCGGACTGAGGGTCACCTGCGCCTGGTGGGGGAGGGGCCGTCCGTGCTGCTCAGTGCGGAGACCACGGCCACCACCC TGCTGGCTGACATGGCCACCACCATCATGGAGACTACCACCACCATGGCCACTACCACCACGCGCCGGGGCCGCTCCCCCACACTGAGGGACAGCACCAC CCAGAACACAGATGACCTGCTGGTGGCCTCTGCTGAGTGTCCAAGCGATGATGAGGACCTGGAGGAGTGTGAGCCCAGTACTGGAGGAGAGTTAATATTG CCCATTATCACGGAGGACTCCTTAGACCCCCCTCCCGTGGCCACCCGATCCCCCTTCGTGCCCCCGCCCCCTACCTTCTACCCCTTCCTCACGGGAGTGG GCGCCACCCAAGACACGCTGCCCCCGCCCGCCGCGCGCCGCCCGCCCTCTGGGGGCCCGTGCCAGGCCGAGCGGGACGACAGCGACTGCGAGGAGCCCAT CGAGGCCTCGGGCTTCGCCTCCGGGGAGGTCTTTGACTCCAGCCTCCCCCCCACGGACGACGAGGACTTTTACACCACCTTTCCCCTGGTCACGGACCGC ACCACCCTCCTGTCACCCCGCAAACCCGCTCCCCGGCCCAACCTCAGGACAGATGGGGCCACGGGCGCCCCTGGGGTGCTGTTTGCCCCCTCCGCCCCGG CCCCCAACCTGCCGGCGGGCAAAATGAACCACCGAGACCCGCTTCAGCCCTTGCTGGAGAACCCGCCCTTGGGGCCCGGGGCCCCCACGTCCTTTGAGCC GCGGAGGCCCCCTCCCCTGCGCCCCGGCGTGACCTCAGCCCCCGGCTTCCCCCATCTGCCCACAGCCAACCCCACAGGGCCTGGGGAGCGGGGCCCGCCG GGCGCAGTGGAGGTGATCCGGGAGTCCAGCAGCACCACGGGCATGGTGGTGGGCATTGTGGCGGCGGCGGCGCTCTGCATCCTCATCCTCCTCTACGCCA TGTATAAGTACCGCAATCGTGATGAGGGCTCCTACCAGGTGGACCAGAGCCGAAACTACATCAGTAACTCGGCCCAGAGCAATGGGGCGGTGGTGAAAGA GAAGGCCCCGGCTGCCCCCAAGACGCCCAGCAAGGCCAAGAAGAACAAAGACAAGGAGTATTATGTCTGAGCCCCCGGCACTGCGCCCCACTGCCAGCTG CCCCTCCTGGGAGGGCCCGGGAGGAGGGTGCCACCCTCTCCCTGCCAGGGGCCTGGGGACCCTCTCCCTGGCTGCCTCAGGCTTCTCTTACGAAGAGGAA ACGCAAAAAAAGAAAAGGAAAAACCCCGTGCTCGCCCCCTTCCTCCTGCCGTCCACTGCGCGGCCTCGTCAGTCCCGGGGCTGACTGTCCCTCTCAGCTC TGCGCCTGCCAGGCAGGGCACGTGCTCACAGCCCTGGGTTGATTTATTTTTTTAAGGGGGTAGTTTTATTTTGGTGGGGTTGGGTGGGAAGGAAGGCTGG GGGTTTTGTAAAGTGTCCACTGCTCGTCCTGTTAATTTTCCTCAATTTTTCTTCTTCTTCCTTCTGTCCCTCCTGCCTTCCTTCTCTTCCCAAGCCCTCC AATCCCCATCCCAGGCTTGCTGTGTCTCACTGTCCCCACCCTCCTTCCCTACTTCTTTTTTTGTGTGTCTGGTTTCTCCCTTCCTTTCCTCCCTTTGGGT TTCCAGAGTCGGTGGGAGAAGGGCGGGAGGGTGGGCCCGAGTGGCCCAGTGGGTGGGTGGGGTGGGGTGGGGCAAGTGCCCCAACTCCCCTCACCAGGAG AGGCACCTGCTTGGTGCCGCCCAGGGAAGGGGCTCAGGCCTGACGGAAGGCCTGTTCTGTGTGTGCCGCCGGGCGACGTGCATTGATGGGGAAGCTGCTG GAGGAGCAGGGGTGGGGGGTGGGAGGGAGGGGAAAGGCAAATGCAGATATATATTACAGACAAATACTCTAGATTCCACGAGCAGCAGCCTGTGGCACCC GCTGGGCGCGGGCAGCAGGGAAGAGGGAGCAAGGCATTGTCCACAGACTGCTGGGGTCACTTCTTTGCCCACGGGCTCCCTGCTCCCCCAGTTTTTTTTC TCTCTTTGTTAACAAATGTGTCTGAGTCTTGGAAAACACCCCAACCCCGGAAATGTGTGGGAAAAAGAAAACAAAAACTTTCCAAATTCCAA

refseq_NRXN2.F3 (forward primer)
refseq_NRXN2.R3 (reverse primer)
Single exon skipping

Frame 0

CRDAAAGAAALTRGASSSERHRGGAGGREAADT ASPGSATRRRRGGPVALLPTLQLLAPREPGIPPC SSVGARGGGGAPPPPPEGSRHLGLCAPRPAAGP MAL*ACKGAPLSAGSARPPPAPCARGSEA*AGA GGRAGPGPP*AWRPGAGGGRHRRRCCCCCCWRWR RARTAWSSAAAPGSGLATRAGRARRAAASSASA CAPTPRARCCSTWTTAATATSWSCCWWTAACGC ASRFRAPSRPRCSWTRRWPTTAGTWCC*PATRAA RRWRWTARPAPPRCAPSGARCRWPATCSWAASR PTCASRRLR*APSSTSRPSAASWPT*SWASGPP RCWAARACAAPPPTRCARPRATPAPTAASAPCWP PARWAATAATRASAASSAAKRSTPWKVRLT*R* TAK*GPYCSPRGGPGEEEPAMCTSQQKARRSLW RPSKAMSSSATTCHTTPSRAALMRSHWPSAPCNA TA*CCIQASRPTTSTCPSSLGLSGWSST*AQVP SRPLWNPSMASSTTTPGTTSGSPETCASTQGLD TLW*TNCIIW*PSRWTGS*PPQATRRRITPCWAL MTSSTLGAAPTQLTCRARPSATTSWAASRTWSI RTMTSNWNYPAWQRKGTPR*SCRGTCHSAVRMW LPWTL*PLRVPRPLWRCPAGALSALAPSP*TSAP PSPMGCCSSARAGGLGVELAATALLSGPTTLPW SYWTATSIFCWTWDLGASSCGHPAARSMMASGV TWTSRGMGEKAPSQ*IVAARRSWPLETARFWTWR VSCTWAVSLRGAGWTCPCPQRCGQQHSGQATWA VCGTSS*MGVAETSGAWLRLRGLWALPPFAPGR R*SSVHLPPVAMGASVEKAGTASSVTASGPAFLG GSVRERPRS*ATMAPCT*RSCCLTPCTRRQRMC PCVSCPSGPTDS*WPPLPGSLPTPYAWSWMGGR *SSLSTSTACASAAHPVKAPKRCLRGTSSMTMSG TR*GWSGVARACSCLWTT*LWRDRWQEPICGWS STTLRRAS*RSGGLSPWCPPTSSGI*VGSCSMA SPTWTSARMVTSPTVSSMLALACVPSWPIPSPSR VAAATWHSPRSKPMLPCTSSSSSRPRPLMGFFC STRATAMTSLSSSWSRGTSTTCLTWGMARP**R GTQTNQSMTTSGTTWWCPGTQATCTRSRLTPALS RSTPMAPETSISKGSCTLAV*ARICSATCPSWW PPGMAFRAAWPQWTSTDVSQTSSPTPCTALGRW RGAVMAPAPPALKSPVPTRASACSSGMASPATAP *LPMEALSAMIPGPHTSLGRGERSSPTRGPPMT GPARGWIAWPWASAPTSGALCWCGWTAPPALET TCSCTSTRAPWG*SLTWARTTLPSTSPTP**ATA NTTWCASLEAAATPPCRWTAGRSTSGTRQETLI TSAWRLLDRESPTGLVE**MSGCSTKAAS*PSS TARLPSRSGAGIRAAPSRARCPASTTMGSRCWRW PPRATPMCGLRVTCAWWGRGRPCCSVRRPRPPP CWLTWPPPSWRLPPPWPLPPRAGAAPPH*GTAP PRTQMTCWWPLLSVQAMMRTWRSVSPVLEES*YC PLSRRTP*TPLPWPPDPPSCPRPLPSTPSSREW APPKTRCPRPPRAARPLGARARPSGTTATARSP SRPRASPPGRSLTPASPPRTTRTFTPPFPWSRTA PPSCHPANPLPGPTSGQMGPRAPLGCCLPPPPR PPTCRRAK*TTETRFSPCWRTRPWGPGPPRPLS RGGPLPCAPA*PQPPASPICPQPTPQGLGSGARR AQWR*SGSPAAPRAWWWALWRRRRSASSSSSTP CISTAIVMRAPTRWTRAETTSVTRPRAMGRW*K RRPRLPPRRPARPRRTKTRSIMSEPPALRPTASC PSWEGPGGGCHPLPARGLGTLSLAASGFSYEEE TQKKKRKNPVLAPFLLPSTARPRQSRG*LSLSA LRLPGRARAHSPGLIYFFKGVVLFWWGWVGRKAG GFVKCPLLVLLIFLNFSSSSFCPSCLPSLPKPS NPHPRLAVSHCPHPPSLLLFLCVWFLPSFPPFG FPESVGEGREGGPEWPSGWVGWGGASAPTPLTRR GTCLVPPREGAQA*RKACSVCAAGRRALMGKLL EEQGWGVGGRGKANADIYYRQIL*IPRAAACGT RWARAAGKREQGIVHRLLGSLLCPRAPCSPSFFS LFVNKCV*VLENTPTPEMCGKKKTKTFQIP

Frame 1

AGMRRREQPP*LAEHPPRRGTAAGRAGARRQTP LALALPPVGDGAAL*LCYPPSSFWRPENQASLP ALLSEPAAGEGRRRRRLREAGIWASARLAPRPGP WHCEPAREPRSARGAPGPLPPHAPAALKPERGP GAGRGRGRRRHGVREPVAADTAAAAVAAAAGAG GARGRPGVRRRPRAVGSLRALGGRGEQRRAQLQP AHQRHARAAALPGRRRRLRLPGAAAGGRPPAAA LHAFVRRAGHAAAGHAGGRRPLAHGAADPRRAP HGAGGGRRGPRRRGALQAARDAGGQRPVRGRHPA RRAPLGAYAEHRQVRAALPRPLGQPEAGRAAPR AAGQPGPARRHRRPAVRARAQPLRQRRPLHRAG PRRGGLRLQPHGLRRQVLQRRGAPHGRSGSPDVK QRSRVLTVLRGGGRERRSRRCAPANKRQGGVCG DLQRQ*VLLLRPVTQPHPEQH**DHTGLPHPAT QRPDAAYRQVGRLRQPVPQVWGCLAGHQPRLRCL RGPCGTRQWQVQRQRLARRPGHPKPAPARRDWT RYGKQTALSGDHLGGRDPDHHRLHAGGLHHAGL **LLLHWGQPQHS*PAGLARQQQLHGLPQGRGL* EQ*LQIGTIPPGKGRGPQDEAAGGLVIPL*GCG CPGPCDL*ESRGLCGAAPLER*AHWLHLPRLPH HRAQWAAALQPGPAGWGWSWQPQLCSAGRLLCHG AIGRPPLSSAGHGIWGHQAAGIQPQGQ*WRVVS RGLPEGWAKRLHLSE*SQHAVLGHWRQRDSGPG E*AVPGRSP*GGPGGPAPAPRGVDSSTPGRLRGL CAGPLHRWA*PRPPGPG*GSGGCGRCPLLLPGD AEAVCICPLSQWGRLSRRLEPLHL*LHRDRLSW AGL*ERGHGPELRWLHVHEDHAA*RHAHGGRGCV PAFHVPAGLRTHDGHHFQGVCRHPTPGAGWGAD EAHCQPRLPARRLRTQ*RPRNAVCGAQAQ*Q*V AHGEGGPAWQEPAAVCGQRDCGGTDGRSPYAAGV PQH*DGHHDGAAVYLRGALQLHRASEWARVQWP ALHGPVQGW*HHLL*AQCSLWPACHRGRSRHLQ ESQQLPGTRHAPSLCFHAPLLPVQDHGP*WASSV QLGQRQ*LHCHRAGQGVHPLRV*PGEWPVLDEG ELRQTSQ*QPVAQRGGVQGPRQRAHAQD*LPHC HAALQWRPKPRSQRGVVHWRSEQEYVQQPAQAGG LPGWLSGLPGLSGPQRTSPRPHRRRPAPHWAGG EGL*WPQHHLH*RVLCQPGRLLAAVGWLHLRLH HDFLWRPCLQ*SRDHIHLWEGGSAHHLHVAPQ*Q AQHEDGSPGRGLQHPPAERCAGAGGQRLRPWRL PAAAHRPGHRGGDL*RGHGRHYHRRAQRHSKRR QIPRGALHSKRRQRHPAGGQLAGQRAVPGRKL** RAPGDC*TENPLPAWSSSR*VAARQRPPADHLQ QPGCHQDRGPGSGPPLPGPGVRPLLQWAQGAGA GRRERPQCAD*GSPAPGGGGAVRAAQCGDHGHHP AG*HGHHHHGDYHHHGHYHHAPGPLPHTEGQHH PEHR*PAGGLC*VSKR**GPGGV*AQYWRRVNI AHYHGGLLRPPSRGHPIPLRAPAPYLLPLPHGSG RHPRHAAPARRAPPALWGPVPGRAGRQRLRGAH RGLGLRLRGGL*LQPPPHGRRGLLHHLSPGHGP HHPPVTPQTRSPAQPQDRWGHGRPWGAVCPLRPG PQPAGGQNEPPRPASALAGEPALGARGPHVL*A AEAPSPAPRRDLSPRLPPSAHSQPHRAWGAGPA GRSGGDPGVQQHHGHGGGHCGGGGALHPHPPLRH V*VPQS**GLLPGGPEPKLHQ*LGPEQWGGGER EGPGCPQDAQQGQEEQRQGVLCLSPRHCAPLPA APPGRAREEGATLSLPGAWGPSPWLPQASLTKRK RKKRKGKTPCSPPSSCRPLRGLVSPGADCPSQL CACQAGHVLTALG*FIFLRG*FYFGGVGWEGRL GVL*SVHCSSC*FSSIFLLLPSVPPAFLLFPSPP IPIPGLLCLTVPTLLPYFFFCVSGFSLPFLPLG FQSRWEKGGRVGPSGPVGGWGGVGQVPQLPSPG EAPAWCRPGKGLRPDGRPVLCVPPGDVH*WGSCW RSRGGGWEGGERQMQIYITDKYSRFHEQQPVAP AGRGQQGRGSKALSTDCWGHFFAHGLPAPPVFF LSLLTNVSESWKTPQPRKCVGKRKQKLSKFQ

Frame 2

QGCGGGSSRPDSRSILLGEAPRRGGRARGGRHR *PWLCHPSETGRPCSSATHPPASGAPRTRHPSL LFCRSPRRGRGAAAAA*GKPASGPLRASPRGRA HGTVSLQGSPAQRGERPAPSRPMRPRL*SLSGGR GPGGAGAAVGMASGSRWRPTPPPLLLLLLLALA ARADGLEFGGGPGQWARYARWAGAASSGELSFS LRTNATRALLLYLDDGGDCDFLELLLVDGRLRLR FTLSCAEPATLQLDTPVADDRWHMVLLTRDARR TALAVDGEARAAEVRSKRREMQVASDLFVGGIP PDVRLSALTLSTVKYEPPFRGLLANLKLGERPPA LLGSQGLRGATADPLCAPARNPCANGGLCTVLA PGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTL NSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVA TFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQR NGLMLHTGKSADYVNLSLKSGAVWLVINLGSGA FEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGH AMVNKLHYLVTISVDGILTTTGYTQEDYTMLGS DDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVY KNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVA ALDPVTFESPEAFVALPRWSAKRTGSISLDFRT TEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAM ELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCH VDFQRDGRKGSISVNSRSTPFLATGDSEILDLE SELYLGGLPEGGRVDLPLPPEVWTAALRAGYVG CVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRET LKQCASAPCRNGGVCREGWNRFICDCIGTGFLG RVCEREATVLSYDGSMYMKIMLPNAMHTEAEDV SLRFMSQRAYGLMMATTSRESADTLRLELDGGQM KLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEW HTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLE FHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQ PYMDQCKDGDITYCELNARFGLRAIVADPVTFK SRSSYLALATLQAYASMHLFFQFKTTAPDGLLL FNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKG NSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTV TQHSNGARNLDLKGELYIGGLSKNMFSNLPKLV ASRDGFQGCLASVDLNGRLPDLIADALHRIGQVE RGCDGPSTTCTEESCANQGVCLQQWDGFTCDCT MTSYGGPVCNDPGTTYIFGKGGALITYTWPPND RPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDY LQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDG KYHVVRFTRSGGNATLQVDSWPVNERYPAGNFD NERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFN SQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLAL AAESDPNVRTEGHLRLVGEGPSVLLSAETTATT LLADMATTIMETTTTMATTTTRRGRSPTLRDSTT QNTDDLLVASAECPSDDEDLEECEPSTGGELIL PIITEDSLDPPPVATRSPFVPPPPTFYPFLTGV GATQDTLPPPAARRPPSGGPCQAERDDSDCEEPI EASGFASGEVFDSSLPPTDDEDFYTTFPLVTDR TTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAP APNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEP RRPPPLRPGVTSAPGFPHLPTANPTGPGERGPP GAVEVIRESSSTTGMVVGIVAAAALCILILLYA MYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKE KAPAAPKTPSKAKKNKDKEYYV*APGTAPHCQL PLLGGPGRRVPPSPCQGPGDPLPGCLRLLLRRG NAKKEKEKPRARPLPPAVHCAASSVPGLTVPLSS APARQGTCSQPWVDLFF*GGSFILVGLGGKEGW GFCKVSTARPVNFPQFFFFFLLSLLPSFSSQAL QSPSQACCVSLSPPSFPTSFFVCLVSPFLSSLWV SRVGGRRAGGWARVAQWVGGVGWGKCPNSPHQE RHLLGAAQGRGSGLTEGLFCVCRRATCIDGEAA GGAGVGGGREGKGKCRYILQTNTLDSTSSSLWHP LGAGSREEGARHCPQTAGVTSLPTGSLLPQFFF SLC*QMCLSLGKHPNPGNVWEKENKNFPNS