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Sequences

Sequence MAP4K4.mAug05

TCACCTCATTAGTGTCCACCTGGCACTGACTGATCAGCACACTATAACATCATGAGAAAGATGGCGGGAAGATCCCTGGTAATTATACATTTTTACTTAC GTAGCAACAAAGGAGAGAGCGGGAAGCTAGAAGGCAGCAGGAACGTGAACAGCGAAGGAGAGAACAAGAAGAAAAGAGGCGTCTAGAGGAGTTGGAGAGA AGGCGCAAAGAAGAAGAGGAGAGGAGACGGGCAGAAGAAGAAAAGAGGAGAGTTGAAAGAGAACAGGAGTATATCAGGCGACAGCTAGAAGAGGAGCAGC GGCACTTGGAAGTCCTTCAGCAGCAGCTGCTCCAGGAGCAGGCCATGTTACTGGAGTGCCGATGGCGGGAGATGGAGGAGCACCGGCAGGCAGAGAGGCT CCAGAGGCAGTTGCAACAAGAACAAGCATATCTCCTGTCTCTACAGCATGACCATAGGAGGCCGCACCCGCAGCACTCGCAGCAGCCGCCACCACCGCAG CAGGAAAGGAGCAAGCCAAGCTTCCATGCTCCCGAGCCCAAAGCCCACTACGAGCCTGCTGACCGAGCGCGAGAGGTACAGTGGTCCCACCTGGCATCTC TCAAGAACAATGTTTCCCCTGTCTCGCGATCCCATTCCTTCAGTGACCCTTCTCCCAAATTTGCACACCACCATCTTCGTTCTCAGGACCCATGTCCACC TTCCCGCAGTGAGGTGCTCAGTCAGAGCTCTGACTCTAAGTCAGAGGCGCCTGACCCTACCCAAAAGGCTTGGTCTAGATCAGACAGTGACGAGGTGCCT CCAAGGGTTCCTGTGAGAACAACATCTCGCTCCCCTGTTCTGTCCCGTCGAGATTCCCCACTGCAGGGCAGTGGGCAGCAGAATAGCCAGGCAGGACAGA GAAACTCCACCAGTATTGAGCCCAGGCTTCTGTGGGAGAGAGTGGAGA

MAP4K4-F1 (forward primer)
MAP4K4-R1 (reverse primer)
Single exon skipping

Frame 0

SPH*CPPGTD*SAHYNIMRKMAGRSLVIIHFYL RSNKGESGKLEGSRNVNSEGENKKKRGV*RSWRE GAKKKRRGDGQKKKRGELKENRSISGDS*KRSS GTWKSFSSSCSRSRPCYWSADGGRWRSTGRQRG SRGSCNKNKHISCLYSMTIGGRTRSTRSSRHHRS RKGASQASMLPSPKPTTSLLTERERYSGPTWHL SRTMFPLSRDPIPSVTLLPNLHTTIFVLRTHVH LPAVRCSVRALTLSQRRLTLPKRLGLDQTVTRCL QGFL*EQHLAPLFCPVEIPHCRAVGSRIARQDR ETPPVLSPGFCGREWR

Frame 1

HLISVHLALTDQHTITS*ERWREDPW*LYIFTY VATKERAGS*KAAGT*TAKERTRRKEASRGVGE KAQRRRGEETGRRRKEES*KRTGVYQATARRGAA ALGSPSAAAAPGAGHVTGVPMAGDGGAPAGREA PEAVATRTSISPVSTA*P*EAAPAALAAAATTA AGKEQAKLPCSRAQSPLRAC*PSARGTVVPPGIS QEQCFPCLAIPFLQ*PFSQICTPPSSFSGPMST FPQ*GAQSEL*L*VRGA*PYPKGLV*IRQ*RGA SKGSCENNISLPCSVPSRFPTAGQWAAE*PGRTE KLHQY*AQASVGESG

Frame 2

TSLVSTWH*LISTL*HHEKDGGKIPGNYTFLLT *QQRREREARRQQEREQRRREQEEKRRLEELER RRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ RHLEVLQQQLLQEQAMLLECRWREMEEHRQAERL QRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQ QERSKPSFHAPEPKAHYEPADRAREVQWSHLAS LKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCPP SRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVP PRVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQ RNSTSIEPRLLWERVE

Sequence MAP4K4.bAug05

GGGCCCGTCCTCGAGGCGCGCGGCGCGGGGCGCGGGCGCCGGGGCCTGAGGCGGCGGGCGACGCCCGGGGGCCTGACGGCCGGCCCCGCGCCATGGTGTG AGCGCCGCCGCCCGTGCACGCTCCGTCCGCCCTCCGCGCGGCCCGGCCGGCAGAGAGCCCCGAGCGGCCCGAGAGCGCAGCCGAGCCCGCCGCCGCCGCC CGCGGCCCCGCGAGGAGAGTACCGGGCCGGCTCGGCTGCCGCGCGAGGAGCGCGGTCGGCGGCCTGGTCTGCGGCTGAGATACACAGAGCGACAGAGACA TTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCT GCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCTATGGACAAGTCTATAAGGGTCGACATGTTAAAACGGGTCAGTTGGCAGCCATCAAAG TTATGGATGTCACTGAGGATGAAGAGGAAGAAATCAAACTGGAGATAAATATGCTAAAGAAATACTCTCATCACAGAAACATTGCAACATATTATGGTGC TTTCATCAAAAAGAGCCCTCCAGGACATGATGACCAACTCTGGCTTGTTATGGAGTTCTGTGGGGCTGGGTCCATTACAGACCTTGTGAAGAACACCAAA GGGAACACACTCAAAGAAGACTGGATCGCTTACATCTCCAGAGAAATCCTGAGGGGACTGGCACATCTTCACATTCATCATGTGATTCACCGGGATATCA AGGGCCAGAATGTGTTGCTGACTGAGAATGCAGAGGTGAAACTTGTTGACTTTGGTGTGAGTGCTCAGCTGGACAGGACTGTGGGGCGGAGAAATACGTT CATAGGCACTCCCTACTGGATGGCTCCTGAGGTCATCGCCTGTGATGAGAACCCAGATGCCACCTATGATTACAGAAGTGATCTTTGGTCTTGTGGCATT ACAGCCATTGAGATGGCAGAAGGTGCTCCCCCTCTCTGTGACATGCATCCAATGAGAGCACTGTTTCTCATTCCCAGAAACCCTCCTCCCCGGCTGAAGT CAAAAAAATGGTCGAAGAAGTTTTTTAGTTTTATAGAAGGGTGCCTGGTGAAGAATTACATGCAGCGGCCCTCTACAGAGCAGCTTTTGAAACATCCTTT TATAAGGGATCAGCCAAATGAAAGGCAAGTTAGAATCCAGCTTAAGGATCATATAGATCGTACCAGGAAGAAGAGAGGCGAGAAAGATGAAACTGAGTAT GAGTACAGTGGGAGTGAGGAAGAAGAGGAGGAAGTGCCTGAACAGGAAGGAGAGCCAAGTTCCATTGTGAACGTGCCTGGTGAGTCTACTCTTCGCCGAG ATTTCCTGAGACTGCAGCAGGAGAACAAGGAACGTTCCGAGGCTCTTCGGAGACAACAGTTACTACAGGAGCAACAGCTCCGGGAGCAGGAAGAATATAA AAGGCAACTGCTGGCAGAGAGACAGAAGCGGATTGAGCAGCAGAAAGAACAGAGGCGACGGCTAGAAGAGCAACAAAGGAGAGAGCGGGAAGCTAGAAGG CAGCAGGAACGTGAACAGCGAAGGAGAGAACAAGAAGAAAAGAGGCGTCTAGAGGAGTTGGAGAGAAGGCGCAAAGAAGAAGAGGAGAGGAGACGGGCAG AAGAAGAAAAGAGGAGAGTTGAAAGAGAACAGGAGTATATCAGGCGACAGCTAGAAGAGGAGCAGCGGCACTTGGAAGTCCTTCAGCAGCAGCTGCTCCA GGAGCAGGCCATGTTACTGGAGTGCCGATGGCGGGAGATGGAGGAGCACCGGCAGGCAGAGAGGCTCCAGAGGCAGTTGCAACAAGAACAAGCATATCTC CTGTCTCTACAGCATGACCATAGGAGGCCGCACCCGCAGCACTCGCAGCAGCCGCCACCACCGCAGCAGGAAAGGAGCAAGCCAAGCTTCCATGCTCCCG AGCCCAAAGCCCACTACGAGCCTGCTGACCGAGCGCGAGAGGTGGAAGATAGATTTAGGAAAACTAACCACAGCTCCCCTGAAGCCCAGTCTAAGCAGAC AGGCAGAGTATTGGAGCCACCAGTGCCTTCCCGATCAGAGTCTTTTTCCAATGGCAACTCCGAGTCTGTGCATCCCGCCCTGCAGAGACCAGCGGAGCCA CAGGTACAGTGGTCCCACCTGGCATCTCTCAAGAACAATGTTTCCCCTGTCTCGCGATCCCATTCCTTCAGTGACCCTTCTCCCAAATTTGCACACCACC ATCTTCGTTCTCAGGACCCATGTCCACCTTCCCGCAGTGAGGTGCTCAGTCAGAGCTCTGACTCTAAGTCAGAGGCGCCTGACCCTACCCAAAAGGCTTG GTCTAGATCAGACAGTGACGAGGTGCCTCCAAGGGTTCCTGTGAGAACAACATCTCGCTCCCCTGTTCTGTCCCGTCGAGATTCCCCACTGCAGGGCAGT GGGCAGCAGAATAGCCAGGCAGGACAGAGAAACTCCACCAGCAGTATTGAGCCCAGGCTTCTGTGGGAGAGAGTGGAGAAGCTGGTGCCCAGACCTGGCA GTGGCAGCTCCTCAGGGTCCAGCAACTCAGGATCCCAGCCCGGGTCTCACCCTGGGTCTCAGAGTGGCTCCGGGGAACGCTTCAGAGTGAGATCATCATC CAAGTCTGAAGGCTCTCCATCTCAGCGCCTGGAAAATGCAGTGAAAAAACCTGAAGATAAAAAGGAAGTTTTCAGACCCCTCAAGCCTGCTGGCGAAGTG GATCTGACCGCACTGGCCAAAGAGCTTCGAGCAGTGGAAGATGTACGGCCACCTCACAAAGTAACGGACTACTCCTCATCCAGTGAGGAGTCGGGGACGA CGGATGAGGAGGACGACGATGTGGAGCAGGAAGGGGCTGACGAGTCCACCTCAGGACCAGAGGACACCAGAGCAGCGTCATCTCTGAATTTGAGCAATGG TGAAACGGAATCTGTGAAAACCATGATTGTCCATGATGATGTAGAAAGTGAGCCGGCCATGACCCCATCCAAGGAGGGCACTCTAATCGTCCGCCAGACT CAGTCCGCTAGTAGCACACTCCAGAAACACAAATCTTCCTCCTCCTTTACACCTTTTATAGACCCCAGATTACTACAGATTTCTCCATCTAGCGGAACAA CAGTGACATCTGTGGTGGGATTTTCCTGTGATGGGATGAGACCAGAAGCCATAAGGCAAGATCCTACCCGGAAAGGCTCAGTGGTCAATGTGAATCCTAC CAACACTAGGCCACAGAGTGACACCCCGGAGATTCGTAAATACAAGAAGAGGTTTAACTCTGAGATTCTGTGTGCTGCCTTATGGGGAGTGAATTTGCTA GTGGGTACAGAGAGTGGCCTGATGCTGCTGGACAGAAGTGGCCAAGGGAAGGTCTATCCTCTTATCAACCGAAGACGATTTCAACAAATGGACGTACTTG AGGGCTTGAATGTCTTGGTGACAATATCTGGCAAAAAGGATAAGTTACGTGTCTACTATTTGTCCTGGTTAAGAAATAAAATACTTCACAATGATCCAGA AGTTGAGAAGAAGCAGGGATGGACAACCGTAGGGGATTTGGAAGGATGTGTACATTATAAAGTTGTAAAATATGAAAGAATCAAATTTCTGGTGATTGCT TTGAAGAGTTCTGTGGAAGTCTATGCGTGGGCACCAAAGCCATATCACAAATTTATGGCCTTTAAGTCATTTGGAGAATTGGTACATAAGCCATTACTGG TGGATCTCACTGTTGAGGAAGGCCAGAGGTTGAAAGTGATCTATGGATCCTGTGCTGGATTCCATGCTGTTGATGTGGATTCAGGATCAGTCTATGACAT TTATCTACCAACACATATCCAGTGTAGCATCAAACCCCATGCAATCATCATCCTCCCCAATACAGATGGAATGGAGCTTCTGGTGTGCTATGAAGATGAG GGGGTTTATGTAAACACATATGGAAGGATCACCAAGGATGTAGTTCTACAGTGGGGAGAGATGCCTACATCAGTAGCATATATTCGATCCAATCAGACAA TGGGCTGGGGAGAGAAGGCCATAGAGATCCGATCTGTGGAAACTGGTCACTTGGATGGTGTGTTCATGCACAAAAGGGCTCAAAGACTAAAATTCTTGTG TGAACGCAATGACAAGGTGTTCTTTGCCTCTGTTCGGTCTGGTGGCAGCAGTCAGGTTTATTTCATGACCTTAGGCAGGACTTCTCTTCTGAGCTGGTAG AAGCAGTGTGATCCAGGGATTACTGGCCTCCAGAGTCTTCAAGATCCTGAGAACTTGGAATTCCTTGTAACTGGAGCTCGGAGCTGCACCGAGGGCAACC AGGACAGCTGTGTGTGCAGACCTCATGTGTTGGGTTCTCTCCCCTCCTTCCTGTTCCTCTTATATACCAGTTTATCCCCATTCTTTTTTTTTTTCTTACT CCAAAATAAATCAAGGCTGCAATGCAGCTGGTGCTGTTCAGATTCTACCATCAGGTGCTATAAGTGTTTGGGATTGAGCATCATACTGGAAAGCAAACAC CTTTCCTCCAGCTCCAGAATTCCTTGTCTCTGAATGACTCTGTCTTGTGGGTGTCTGACAGTGGCGACGATGAACATGCCGTTGGTTTTATTGGCAGTGG GCACAAGGAGGTGAGAAGTGGTGGTAAAAGGAGCGGAGTGCTGAAGCAGAGAGCAGATTTAATATAGTAACATTAACAGTGTATTTAATTGACATTTCTT TTTTGTAATGTGACGATATGTGGACAAAGAAGAAGATGCAGGTTTAAGAAGTTAATATTTATAAAATGTGAAAGACACAGTTACTAGGATAACTTTTTTG TGGGTGGGGCTTGGGAGATGGGGTGGGGTGGGTTAAGGGGTCCCATTTTGTTTCTTTGGATTTGGGGTGGGGGTCCTGGCCAAGAACTCAGTCATTTTTC TGTGTACCAGGTTGCCTAAATCATGTGCAGATGGTTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGAAAAAAAAAAAGAAAAAGAAAACGTGTGCATT TTGTATAATGGCCAGAACTTTGTCGTGTGACAGTATTAGCACTGCCTCAGTTAAAGGTTTAATTTTTGTTTAAACCTAGACGTGCAACAAAAGTTTTACC ACAGTCTGCACTTGCAGAAGAAAGAAAAAAATTCAAACCACATGTTTATTTTTTTTTTGCCTACCTCATTGTTCTTAATGCATTGAGAGGTGATTTAGTT TATATGTTTTTGGAAGAAACCATTAATGTTTAATTTAATCTTAATACCAAAACGACCAGATTGAAGTTTGACTTTTATTGTCACAAATCAGCAGGCACAA GAACTGTCCATGAAGATGGGAAATAGCCTTAAGGCTGATGCAGTTTACTTACAAGTTTAGAAACCAGAATGCTTTGTTTTTACCAGATTCACCATTAGAG GTTGATGGGGCAACTGCAGCCCATGACACAAGATCTCATTGTTCTCGATGTAGAGGGGTTGGTAGCAGACAGGTGGTTACATTAGAATAGTCACACAAAC TGTTCAGTGTTGCAGGAACCTTTTCTTGGGGGTGGGGGAGTTTCCCTTTTCTAAAAATGCAATGCACTAAAACTATTTTAAGAATGTAGTTAATTCTGCT TATTCATAAAGTGGGCATCTTCTGTGTTTTAGGTGTAATATCGAAGTCCTGGCTTTTCTCGTTTTCTCACTTGCTCTCTTGTTCTCTGTTTTTTTAAACC AATTTTACTTTATGAATATATTCATGACATTTGTAATAAATGTCTTGAGAAAGAATTTGTTTCATGGCTTCATGGTCATCACTCAAGCTCCCGTAAGGAT ATTACCGTCTCAGGAAAGGATCAGGACTCCATGTCACAGTCCTGCCATCTTACTTTCCTCTTGTCGAGTTCTGAGTGGAAATAACTGCATTATGGCTGCT TTAACCTCAGTCATCAAAAGAAACTTGCTGTTTTTTAGGCTTGATCTTTTTCCTTTGTGGTTAATTTTCCTGTATATTGTGAAAATGGGGGATTTTCCCT CTGCTCCCACCCACCTAAACACAGCAGCCATTTGTACCTGTTTGCTTCCCATCCCACTTGGCACCCACTCTGACCTCTTGTCAGTTTCCTGTTCCTGGTT CCATCTTTTTGAAAAAGGCCCTCCTTTGAGCTACAAACATCTGGTAAGACAAGTACATCCACTCATGAATGCAGACACAGCAGCTGGTGGTTTTGTGTAT ACCTGTAAAGACAAGCTGAGAAGCTTACTTTTTGGGGAAGTAAAAGAAGATGGAAATGGATGTTTCATTTGTATGAGTTTGGAGCAGTGCTGAAGGCCAA AGCCGCCTACTGGTTTGTAGTTAACCTAGAGAAGGTTGAAAAATTAATCCTACCTTTAAAGGGATTTGAGGTAGGCTGGATTCCATCGCCACAGGACTTT AGTTAGAATTAAATTCCTGCTTGTAATTTATATCCATGTTTAGGCTTTTCATAAGATGAAACATGCCACAGTGAACACACTCGTGTACATATCAAGAGAA GAAGGAAAGGCACAGGTGGAGAACAGTAAAAGGTGGGCAGATGTCTTTGAAGAAATGCTCAATGTCTGATGCTAAGTGGGAGAAGGCAGAGAACAAAGGA TGTGGCATAATGGTCTTAACATTATCCAAAGACTTGAAGCTCCATGTCTGTAAGTCAAATGTTACACAAAAAAAAATGCAAATGGTGTTTCATTGGAATT ACCAAGTGCTTAGAACTTGCTGGCTTTCCCATAGGTGGTAAAGGGGTCTGAGCTCACACCGAGTTGTGCTTGGCTTGCTTGTGCAGCTCCAGGCACCCGG TGGGCACTCTGGTGGTGTTTGTGGTGAACTGAATTGAATCCATTGTTGGGCTTAAGTTACTGAAATTGGAACACCCTTTGTCCTTCTCGGCGGGGGCTTC CTGGTCTGTGCTTTACTTGGCTTTTTTCCTTCCCGTCTTAGCCTCACCCCCTTGTCAACCAGATTGAGTTGCTATAGCTTGATGCAGGGACCCAGTGAAG TTTCTCCGTTAAAGATTGGGAGTCGTCGAAATGTTTAGATTCTTTTAGGAAAGGAATTATTTTCCCCCCTTTTACAGGGTAGTAACTTCTCCACAGAAGT GCCAATATGGCAAAATTACACAAGAAAACAGTATTGCAATGACACCATTACATAAGGAACATTGAACTGTTAGAGGAGTGCTCTTCCAAACAAAACAAAA ATGTCTCTAGGTTTAGTCAGAGCTTTCACAAGTAATAACCTTTCTGTATTAAAATCAGAGTAACCCTTTCTGTATTGAGTGCAGTGTTTTTTACTCTTTT CTCATGCACATGTTACGTTGGAGAAAATGTTTACAAAAATGGTTTTGTTACACTAATGCGCACCACATATTTATGGTTTATTTTAAGTGACTTTTTATGG GTTATTTAGGTTTTCGTCTTAGTTGTAGCACACTTACCCTAATTTTGCCAATTATTAATTTGCTAAATAGTAATACAAATGACAAACTGCATTAAATTTA CTAATTATAAAAGCTGCAAAGCAGACTGGTGGCAAGTACACAGCCCTTTTTTTTGCAGTGCTAACTTGTCTACTGTGTATTATGAAAATTACTGTTGTCC CCCCACCCTTTTTTCCTTAAATAAAGTAAAAATGACACCTATTTTATGTGGCATGAGTTTCGAATATGTTCTGACCCTTCAGAATGTTTCCTTCCTGTGA GGATCCATATTTTATGCATACCTGCCTACCCTGAGCTTCCCGTACCAGAGCAGGCTCCTGTATTTTGCTATTTCAGATGACAGGGGCTTGCCCAAGGCCA GGTATAGATTACAAAAGTAGCAAATGTTTGTCTAAAGACCTCAGAGATGAAGTGGGAGATGAACCTCCATCACCAGGTTCCTGAAGACAGTATGGAGTAA AGCTGGTCCTTAAAGAAATGTCACATTTTTGCAGTTTTGAATTTGGATCAAAAAATA

MAP4K4-F1 (forward primer)
MAP4K4-R1 (reverse primer)
Single exon skipping

Frame 0

GPVLEARGAGRGRRGLRRRATPGGLTAGPAPWC ERRRPCTLRPPSARPGRQRAPSGPRAQPSPPPPP AAPRGEYRAGSAAARGARSAAWSAAEIHRATET FIVICFLVAKRENGERLPCKKSGGHRPLLPAGS CWDF*AGGSGWKWHLWTSL*GSTC*NGSVGSHQS YGCH*G*RGRNQTGDKYAKEILSSQKHCNILWC FHQKEPSRT**PTLACYGVLWGWVHYRPCEEHQ REHTQRRLDRLHLQRNPEGTGTSSHSSCDSPGYQ GPECVAD*ECRGETC*LWCECSAGQDCGAEKYV HRHSLLDGS*GHRL**EPRCHL*LQK*SLVLWH YSH*DGRRCSPSL*HASNESTVSHSQKPSSPAEV KKMVEEVF*FYRRVPGEELHAAALYRAAFETSF YKGSAK*KAS*NPA*GSYRSYQEEERRER*N*V *VQWE*GRRGGSA*TGRRAKFHCERAW*VYSSPR FPETAAGEQGTFRGSSETTVTTGATAPGAGRI* KATAGRETEAD*AAERTEATARRATKERAGS*K AAGT*TAKERTRRKEASRGVGEKAQRRRGEETGR RRKEES*KRTGVYQATARRGAAALGSPSAAAAP GAGHVTGVPMAGDGGAPAGREAPEAVATRTSIS PVSTA*P*EAAPAALAAAATTAAGKEQAKLPCSR AQSPLRAC*PSARGGR*I*EN*PQLP*SPV*AD RQSIGATSAFPIRVFFQWQLRVCASRPAETSGA TGTVVPPGISQEQCFPCLAIPFLQ*PFSQICTPP SSFSGPMSTFPQ*GAQSEL*L*VRGA*PYPKGL V*IRQ*RGASKGSCENNISLPCSVPSRFPTAGQ WAAE*PGRTEKLHQQY*AQASVGESGEAGAQTWQ WQLLRVQQLRIPARVSPWVSEWLRGTLQSEIII QV*RLSISAPGKCSEKT*R*KGSFQTPQACWRS GSDRTGQRASSSGRCTATSQSNGLLLIQ*GVGDD G*GGRRCGAGRG*RVHLRTRGHQSSVISEFEQW *NGICENHDCP**CRK*AGHDPIQGGHSNRPPD SVR**HTPETQIFLLLYTFYRPQITTDFSI*RNN SDICGGIFL*WDETRSHKARSYPERLSGQCESY QH*ATE*HPGDS*IQEEV*L*DSVCCLMGSEFA SGYREWPDAAGQKWPREGLSSYQPKTISTNGRT* GLECLGDNIWQKG*VTCLLFVLVKK*NTSQ*SR S*EEAGMDNRRGFGRMCTL*SCKI*KNQISGDC FEEFCGSLCVGTKAISQIYGL*VIWRIGT*AITG GSHC*GRPEVESDLWILCWIPCC*CGFRISL*H LSTNTYPV*HQTPCNHHPPQYRWNGASGVL*R* GGLCKHIWKDHQGCSSTVGRDAYISSIYSIQSDN GLGREGHRDPICGNWSLGWCVHAQKGSKTKILV *TQ*QGVLCLCSVWWQQSGLFHDLRQDFSSELV EAV*SRDYWPPESSRS*ELGIPCNWSSELHRGQP GQLCVQTSCVGFSPLLPVPLIYQFIPILFFFLT PK*IKAAMQLVLFRFYHQVL*VFGIEHHTGKQT PFLQLQNSLSLNDSVLWVSDSGDDEHAVGFIGSG HKEVRSGGKRSGVLKQRADLI**H*QCI*LTFL FCNVTICGQRRRCRFKKLIFIKCERHSY*DNFF VGGAWEMGWGGLRGPILFLWIWGGGPGQELSHFS VYQVA*IMCRWF*KKKKKKKKKEKKKEKENVCI LYNGQNFVV*QY*HCLS*RFNFCLNLDVQQKFY HSLHLQKKEKNSNHMFIFFLPTSLFLMH*EVI*F ICFWKKPLMFNLILIPKRPD*SLTFIVTNQQAQ ELSMKMGNSLKADAVYLQV*KPECFVFTRFTIR G*WGNCSP*HKISLFSM*RGW*QTGGYIRIVTQT VQCCRNLFLGVGEFPFSKNAMH*NYFKNVVNSA YS*SGHLLCFRCNIEVLAFLVFSLALLFSVFLN QFYFMNIFMTFVINVLRKNLFHGFMVITQAPVRI LPSQERIRTPCHSPAILLSSCRVLSGNNCIMAA LTSVIKRNLLFFRLDLFPLWLIFLYIVKMGDFP SAPTHLNTAAICTCLLPIPLGTHSDLLSVSCSWF HLFEKGPPLSYKHLVRQVHPLMNADTAAGGFVY TCKDKLRSLLFGEVKEDGNGCFICMSLEQC*RP KPPTGL*LT*RRLKN*SYL*RDLR*AGFHRHRTL VRIKFLLVIYIHV*AFHKMKHATVNTLVYISRE EGKAQVENSKRWADVFEEMLNV*C*VGEGREQR MWHNGLNIIQRLEAPCL*VKCYTKKNANGVSLEL PSA*NLLAFP*VVKGSELTPSCAWLACAAPGTR WALWWCLW*TELNPLLGLSY*NWNTLCPSRRGL PGLCFTWLFSFPS*PHPLVNQIELL*LDAGTQ*S FSVKDWESSKCLDSFRKGIIFPPFTG**LLHRS ANMAKLHKKTVLQ*HHYIRNIELLEECSSKQNK NVSRFSQSFHK**PFCIKIRVTLSVLSAVFFTLF SCTCYVGENVYKNGFVTLMRTTYLWFILSDFLW VI*VFVLVVAHLP*FCQLLIC*IVIQMTNCIKF TNYKSCKADWWQVHSPFFCSANLSTVYYENYCCP PTLFSLNKVKMTPILCGMSFEYVLTLQNVSFL* GSIFYAYLPTLSFPYQSRLLYFAISDDRGLPKA RYRLQK*QMFV*RPQR*SGR*TSITRFLKTVWSK AGP*RNVTFLQF*IWIKK

Frame 1

GPSSRRAARGAGAGA*GGGRRPGA*RPAPRHGV SAAARARSVRPPRGPAGREPRAARERSRARRRR PRPREESTGPARLPREERGRRPGLRLRYTERQRH LLLFVFWWQKGKMANDSPAKSLVDIDLSSLRDP AGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIK VMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGA FIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTK GNTLKEDWIAYISREILRGLAHLHIHHVIHRDI KGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTF IGTPYWMAPEVIACDENPDATYDYRSDLWSCGI TAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLK SKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPF IRDQPNERQVRIQLKDHIDRTRKKRGEKDETEY EYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRR DFLRLQQENKERSEALRRQQLLQEQQLREQEEYK RQLLAERQKRIEQQKEQRRRLEEQQRREREARR QQEREQRRREQEEKRRLEELERRRKEEEERRRA EEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQ EQAMLLECRWREMEEHRQAERLQRQLQQEQAYL LSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAP EPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQT GRVLEPPVPSRSESFSNGNSESVHPALQRPAEP QVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHH HLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKAW SRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGS GQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPG SGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSS KSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEV DLTALAKELRAVEDVRPPHKVTDYSSSSEESGT TDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQT QSASSTLQKHKSSSSFTPFIDPRLLQISPSSGT TVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPT NTRPQSDTPEIRKYKKRFNSEILCAALWGVNLL VGTESGLMLLDRSGQGKVYPLINRRRFQQMDVL EGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPE VEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIA LKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLL VDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI YLPTHIQCSIKPHAIIILPNTDGMELLVCYEDE GVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQT MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC ERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW* KQCDPGITGLQSLQDPENLEFLVTGARSCTEGN QDSCVCRPHVLGSLPSFLFLLYTSLSPFFFFFLL QNKSRLQCSWCCSDSTIRCYKCLGLSIILESKH LSSSSRIPCL*MTLSCGCLTVATMNMPLVLLAV GTRR*EVVVKGAEC*SREQI*YSNINSVFN*HFF FVM*RYVDKEEDAGLRS*YL*NVKDTVTRITFL WVGLGRWGGVG*GVPFCFFGFGVGVLAKNSVIF LCTRLPKSCADGSKKKKKKKKKRKKKKKKKTCAF CIMARTLSCDSISTASVKGLIFV*T*TCNKSFT TVCTCRRKKKIQTTCLFFFCLPHCS*CIER*FS LYVFGRNH*CLI*S*YQNDQIEV*LLLSQISRHK NCP*RWEIALRLMQFTYKFRNQNALFLPDSPLE VDGATAAHDTRSHCSRCRGVGSRQVVTLE*SHK LFSVAGTFSWGWGSFPFLKMQCTKTILRM*LILL IHKVGIFCVLGVISKSWLFSFSHLLSCSLFF*T NFTL*IYS*HL**MS*ERICFMASWSSLKLP*G YYRLRKGSGLHVTVLPSYFPLVEF*VEITALWLL *PQSSKETCCFLGLIFFLCG*FSCIL*KWGIFP LLPPT*TQQPFVPVCFPSHLAPTLTSCQFPVPG SIFLKKALL*ATNIW*DKYIHS*MQTQQLVVLCI PVKTS*EAYFLGK*KKMEMDVSFV*VWSSAEGQ SRLLVCS*PREG*KINPTFKGI*GRLDSIATGL *LELNSCL*FISMFRLFIR*NMPQ*THSCTYQEK KERHRWRTVKGGQMSLKKCSMSDAKWEKAENKG CGIMVLTLSKDLKLHVCKSNVTQKKMQMVFHWN YQVLRTCWLSHRW*RGLSSHRVVLGLLVQLQAPG GHSGGVCGELN*IHCWA*VTEIGTPFVLLGGGF LVCALLGFFPSRLSLTPLSTRLSCYSLMQGPSE VSPLKIGSRRNV*ILLGKELFSPLLQGSNFSTEV PIWQNYTRKQYCNDTIT*GTLNC*RSALPNKTK MSLGLVRAFTSNNLSVLKSE*PFLY*VQCFLLF SHAHVTLEKMFTKMVLLH*CAPHIYGLF*VTFYG LFRFSS*L*HTYPNFANY*FAK**YK*QTALNL LIIKAAKQTGGKYTALFFAVLTCLLCIMKITVV PPPFFP*IK*K*HLFYVA*VSNMF*PFRMFPSCE DPYFMHTCLP*ASRTRAGSCILLFQMTGACPRP GIDYKSSKCLSKDLRDEVGDEPPSPGS*RQYGV KLVLKEMSHFCSFEFGSKN

Frame 2

ARPRGARRGARAPGPEAAGDARGPDGRPRAMV* APPPVHAPSALRAARPAESPERPESAAEPAAAA RGPARRVPGRLGCRARSAVGGLVCG*DTQSDRD IYCYLFFGGKKGKWRTTPLQKVWWTSTSPPCGIL LGFLSWWKWLEMAPMDKSIRVDMLKRVSWQPSK LWMSLRMKRKKSNWR*IC*RNTLITETLQHIMV LSSKRALQDMMTNSGLLWSSVGLGPLQTL*RTPK GTHSKKTGSLTSPEKS*GDWHIFTFIM*FTGIS RARMCC*LRMQR*NLLTLV*VLSWTGLWGGEIR S*ALPTGWLLRSSPVMRTQMPPMITEVIFGLVAL QPLRWQKVLPLSVTCIQ*EHCFSFPETLLPG*S QKNGRRSFLVL*KGAW*RITCSGPLQSSF*NIL L*GISQMKGKLESSLRII*IVPGRREARKMKLSM STVGVRKKRRKCLNRKESQVPL*TCLVSLLFAE IS*DCSRRTRNVPRLFGDNSYYRSNSSGSRKNI KGNCWQRDRSGLSSRKNRGDG*KSNKGESGKLEG SRNVNSEGENKKKRGV*RSWREGAKKKRRGDGQ KKKRGELKENRSISGDS*KRSSGTWKSFSSSCS RSRPCYWSADGGRWRSTGRQRGSRGSCNKNKHIS CLYSMTIGGRTRSTRSSRHHRSRKGASQASMLP SPKPTTSLLTERERWKIDLGKLTTAPLKPSLSR QAEYWSHQCLPDQSLFPMATPSLCIPPCRDQRSH RYSGPTWHLSRTMFPLSRDPIPSVTLLPNLHTT IFVLRTHVHLPAVRCSVRALTLSQRRLTLPKRL GLDQTVTRCLQGFL*EQHLAPLFCPVEIPHCRAV GSRIARQDRETPPAVLSPGFCGREWRSWCPDLA VAAPQGPATQDPSPGLTLGLRVAPGNASE*DHH PSLKALHLSAWKMQ*KNLKIKRKFSDPSSLLAKW I*PHWPKSFEQWKMYGHLTK*RTTPHPVRSRGR RMRRTTMWSRKGLTSPPQDQRTPEQRHL*I*AM VKRNL*KP*LSMMM*KVSRP*PHPRRAL*SSARL SPLVAHSRNTNLPPPLHLL*TPDYYRFLHLAEQ Q*HLWWDFPVMG*DQKP*GKILPGKAQWSM*IL PTLGHRVTPRRFVNTRRGLTLRFCVLPYGE*IC* WVQRVA*CCWTEVAKGRSILLSTEDDFNKWTYL RA*MSW*QYLAKRISYVSTICPG*EIKYFTMIQ KLRRSRDGQP*GIWKDVYIIKL*NMKESNFW*LL *RVLWKSMRGHQSHITNLWPLSHLENWYISHYW WISLLRKARG*K*SMDPVLDSMLLMWIQDQSMT FIYQHISSVASNPMQSSSSPIQMEWSFWCAMKMR GFM*THMEGSPRM*FYSGERCLHQ*HIFDPIRQ WAGERRP*RSDLWKLVTWMVCSCTKGLKD*NSC VNAMTRCSLPLFGLVAAVRFIS*P*AGLLF*AGR SSVIQGLLASRVFKILRTWNSL*LELGAAPRAT RTAVCADLMCWVLSPPSCSSYIPVYPHSFFFSY SKINQGCNAAGAVQILPSGAISVWD*ASYWKANT FPPAPEFLVSE*LCLVGV*QWRR*TCRWFYWQW AQGGEKWW*KERSAEAESRFNIVTLTVYLIDIS FL*CDDMWTKKKMQV*EVNIYKM*KTQLLG*LFC GWGLGDGVGWVKGSHFVSLDLGWGSWPRTQSFF CVPGCLNHVQMVLKKKKKKKKKGKKKRKRKRVH FV*WPELCRVTVLALPQLKV*FLFKPRRATKVLP QSALAEERKKFKPHVYFFFAYLIVLNALRGDLV YMFLEETINV*FNLNTKTTRLKFDFYCHKSAGT RTVHEDGK*P*G*CSLLTSLETRMLCFYQIHH*R LMGQLQPMTQDLIVLDVEGLVADRWLH*NSHTN CSVLQEPFLGGGGVSLF*KCNALKLF*ECS*FC LFIKWASSVF*V*YRSPGFSRFLTCSLVLCFFKP ILLYEYIHDICNKCLEKEFVSWLHGHHSSSRKD ITVSGKDQDSMSQSCHLTFLLSSSEWK*LHYGC FNLSHQKKLAVF*A*SFSFVVNFPVYCENGGFSL CSHPPKHSSHLYLFASHPTWHPL*PLVSFLFLV PSF*KRPSFELQTSGKTSTSTHECRHSSWWFCV YL*RQAEKLTFWGSKRRWKWMFHLYEFGAVLKAK AAYWFVVNLEKVEKLILPLKGFEVGWIPSPQDF S*N*IPACNLYPCLGFS*DETCHSEHTRVHIKR RRKGTGGEQ*KVGRCL*RNAQCLMLSGRRQRTKD VA*WS*HYPKT*SSMSVSQMLHKKKCKWCFIGI TKCLELAGFPIGGKGV*AHTELCLACLCSSRHP VGTLVVFVVN*IESIVGLKLLKLEHPLSFSAGAS WSVLYLAFFLPVLASPPCQPD*VAIA*CRDPVK FLR*RLGVVEMFRFF*ERNYFPPFYRVVTSPQK CQYGKITQENSIAMTPLHKEH*TVRGVLFQTKQK CL*V*SELSQVITFLY*NQSNPFCIECSVFYSF LMHMLRWRKCLQKWFCYTNAHHIFMVYFK*LFM GYLGFRLSCSTLTLILPIINLLNSNTNDKLH*IY *L*KLQSRLVASTQPFFLQC*LVYCVL*KLLLS PHPFFLK*SKNDTYFMWHEFRICSDPSECFLPV RIHILCIPAYPELPVPEQAPVFCYFR*QGLAQGQ V*ITKVANVCLKTSEMKWEMNLHHQVPEDSME* SWSLKKCHIFAVLNLDQKI