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Sequence CASP3.eAug05
AGCACATCTCCCGGCGGCGGGCCGCGGAAGCAGTGCAGACGCGGCTCCTAGCGGATGGGTGCTATTGTGAGGCGGTTGTAGAAGTTAATAAAGGTATCCATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATCATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGA
CAACAGTTATAAAATGGATTATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGAATGACATCTCGGTCTGGTACA
GATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAACTTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATGC
GTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGCCATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGT
TGACCTGAAAAAAATAACAAACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATTCAGGTTATTATTCTTGGCGAA
ATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGTGCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAACCG
AAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAACAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTAT
TTTTATCACTAAAGAAATGGTTGGTTGGTGGTTTTTTTTAGTTTGTATGCCAAGTGAGAAGATGGTATATTTGGTACTGTATTTCCCTCTCATTTTGACC
TACTCTCATGCTGCAGAGGGTACTTTAAGACATACTCCTTCCATCAAATAGAACCACTATGAAGCTACCTCAAACTTCCAGTCAGGTAGTTGCAATTGAA
TTAAATTAGGAATAAATAAAAATGGATACTGGTGCAGTCATTATGAGAGGCAATGATTGTTAATTTACAGCTTTCATGATTAGCAAGTTACAGTGATGCT
GTGCTATGAATTTTCAAGTAATTGTGAAAAAGTTAAACATTGAAGTAATGAATTTTTATGATATTCCCCCCACTTAAGACTGTGTATTCTAGTTTTGTCA
AACTGTAGAAATGATGATGTGGAAGAACTTAGGCATCTGTGGGCATGGTCAAAGGCTCAAACCTTTATTTTAGAATTGATATACACGGATGACTTAACTG
CATTTTTAGACCATTTATCTGGGATTATGGTTTTGTGATGTTTGTCCTGAACACTTTTGTTGTAAAAAAATAATAATAATGTTTAATATTGAGAAAGAAA
CTAATATTTTATGTGAGAGAAAGTGTGAGCAAACTAACTTGACTTTTAAGGCTAAAACTTAACATTCATAGAGGGGTGGAGTTTTAACTGTAAGGTGCTA
CAATGCCCCTGGATCTACCAGCATAAATATCTTCTGATTTGTCCCTATGCATATCAGTTGAGCTTCATATACCAGCAATATATCTGAAGAGCTATTATAT
AAAAACCCCAAACTGTTGATTATTAGCCAGGTAATGTGAATAAATTCTATAGGAACATATGAAAATACAACTTAAATAATAAACAGTGGAATATAAGGAA
AGCAATAAATGAATGGGCTGAGCTGCCTGTAACTTGAGAGTAGATGGTTTGAGCCTGAGCAGAGACATGACTCAGCCTGTTCCATGAAGGCAGAGCCATG
GACCACGCAGGAAGGGCCTACAGCCCATTTCTCCATACGCACTGGTATGTGTGGATGATGCTGCCAGGGCGCCATCGCCAAGTAAGAAAGTGAAGCAAAT
CAGAAACTTGTGAAGTGGAAATGTTCTAAAGGTGGTGAGGCAATAAAAATCATAGTACTCTTTGTAGCAAAATTCTTAAGTATGTTATTTTCTGTTGAAG
TTTACAATCAAAGGAAAATAGTAATGTTTTATACTGTTTACTGAAAGAAAAAGACCTATGAGCACATAGGACTCTAGACGGCATCCAGCCGGAGGCCAGA
GCTGAGCCCTCAGCCCGGGAGGCAGGCTCCAGGCCTCAGCAGGTGCGGAGCCGTCACTGCACCAAGTCTCACTGGCTGTCAGTATGACATTTCACGGGAG
ATTTCTTGTTGCTCAAAAAATGAGCTCGCATTTGTCAATGACAGTTTCTTTTTTCTTACTAGACCTGTAACTTTTGTAAATACACATAGCATGTAATGGT
ATCTTAAAGTGTGTTTCTATGTGACAATTTTGTACAAATTTGTTATTTTCCATTTTTATTTCAAAATATACATTCAAACTTAAAATTACCAA
- CASP3.u.f.5 (forward primer)
- CASP3.u.r.6 (reverse primer)
- Single exon skipping
Frame 0
STSPGGGPRKQCRRGS*RMGAIVRRL*KLIKVSMENTENSVDSKSIKNLEPKIIHGSESMDSGISLD
NSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGT
DVDAANLRETFRNLKYEVRNKNDLTREEIVELM
RDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPV
DLKKITNFFRGDRCRSLTGKPKLFIIQVIILGE
IQRMAPGSSSRFVPC*NSMPTSLNLCTFLPGLT
ERWQQNLSPFPLTLLFMQRNRFHVLFPCSQKNSI
FITKEMVGWWFFLVCMPSEKMVYLVLYFPLILT
YSHAAEGTLRHTPSIK*NHYEATSNFQSGSCN*
IKLGINKNGYWCSHYERQ*LLIYSFHD*QVTVML
CYEFSSNCEKVKH*SNEFL*YSPHLRLCILVLS
NCRNDDVEELRHLWAWSKAQTFILELIYTDDLT
AFLDHLSGIMVL*CLS*TLLL*KNNNNV*Y*ERN
*YFM*EKV*AN*LDF*G*NLTFIEGWSFNCKVL
QCPWIYQHKYLLICPYAYQLSFIYQQYI*RAII
*KPQTVDY*PGNVNKFYRNI*KYNLNNKQWNIRK
AINEWAELPVT*E*MV*A*AET*LSLFHEGRAM
DHAGRAYSPFLHTHWYVWMMLPGRHRQVRK*SK
SETCEVEMF*RW*GNKNHSTLCSKILKYVIFC*S
LQSKENSNVLYCLLKEKDL*AHRTLDGIQPEAR
AEPSAREAGSRPQQVRSRHCTKSHWLSV*HFTG
DFLLLKK*ARICQ*QFLFSY*TCNFCKYT*HVMV
S*SVFLCDNFVQICYFPFLFQNIHSNLKLP
Frame 1
AHLPAAGRGSSADAAPSGWVLL*GGCRS**RYPWRTLKTQWIQNPLKIWNQRSYMEANQWTLEYPW
TTVIKWIILRWVYV**LIIRIFIKALE*HLGLVQ
MSMQQTSGKHSET*NMKSGIKMILHVKKLWN*C
VMFLKKITAKGAVLFVCF*AMVKKE*FLEQMDL
LT*KK*QTFSEGIVVEV*LENPNFSLFRLLFLAK
FKGWLLVHPVALCHAETVCRQA*IYAHSYPG*P
KGGNRI*VLFL*RYFSCKETDSMYCFHAHKRTL
FLSLKKWLVGGFF*FVCQVRRWYIWYCISLSF*P
TLMLQRVL*DILLPSNRTTMKLPQTSSQVVAIE
LN*E*IKMDTGAVIMRGNDC*FTAFMISKLQ*C
CAMNFQVIVKKLNIEVMNFYDIPPT*DCVF*FCQ
TVEMMMWKNLGICGHGQRLKPLF*N*YTRMT*L
HF*TIYLGLWFCDVCPEHFCCKKIIIMFNIEKE
TNILCERKCEQTNLTFKAKT*HS*RGGVLTVRCY
NAPGSTSINIF*FVPMHIS*ASYTSNISEELLY
KNPKLLIISQVM*INSIGTYENTT*IINSGI*G
KQ*MNGLSCL*LESRWFEPEQRHDSACSMKAEPW
TTQEGPTAHFSIRTGMCG*CCQGAIAK*ESEAN
QKLVKWKCSKGGEAIKIIVLFVAKFLSMLFSVE
VYNQRKIVMFYTVY*KKKTYEHIGL*TASSRRPE
LSPQPGRQAPGLSRCGAVTAPSLTGCQYDISRE
ISCCSKNELAFVNDSFFFLTRPVTFVNTHSM*W
YLKVCFYVTILYKFVIFHFYFKIYIQT*NYQ
Frame 2
HISRRRAAEAVQTRLLADGCYCEAVVEVNKGIHGEH*KLSGFKIH*KFGTKDHTWKRINGLWNIPG
QQL*NGLS*DGFMYNN***EFS*KHWNDISVWY
RCRCSKPQGNIQKLEI*SQE*K*SYT*RNCGIDA
*CF*RRSQQKEQFCLCASEPW*RRNNFWNKWTC
*PEKNNKLFQRGSL*KSNWKTQTFHYSGYYSWR
NSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNR
KVATEFESFSFDATFHAKKQIPCIVSMLTKELY
FYH*RNGWLVVFFSLYAK*EDGIFGTVFPSHFD
LLSCCRGYFKTYSFHQIEPL*SYLKLPVR*LQLN
*IRNK*KWILVQSL*EAMIVNLQLS*LASYSDA
VL*IFK*L*KS*TLK**IFMIFPPLKTVYSSFV
KL*K**CGRT*ASVGMVKGSNLYFRIDIHG*LNC
IFRPFIWDYGFVMFVLNTFVVKK***CLILRKK
LIFYVRESVSKLT*LLRLKLNIHRGVEF*L*GA
TMPLDLPA*ISSDLSLCISVELHIPAIYLKSYYI
KTPNC*LLAR*CE*IL*EHMKIQLK**TVEYKE
SNK*MG*AACNLRVDGLSLSRDMTQPVP*RQSH
GPRRKGLQPISPYALVCVDDAARAPSPSKKVKQI
RNL*SGNVLKVVRQ*KS*YSL*QNS*VCYFLLK
FTIKGK**CFILFTERKRPMST*DSRRHPAGGQ
S*ALSPGGRLQASAGAEPSLHQVSLAVSMTFHGR
FLVAQKMSSHLSMTVSFFLLDL*LL*IHIACNG
ILKCVSM*QFCTNLLFSIFISKYTFKLKIT
Sequence CASP3.bAug05
AGCACATCTCCCGGCGGCGGGCCGCGGAAGCAGTGCAGACGCGGCTCCTAGCGGATGGGTGCTATTGTGAGGCGGTTGTAGAAGTTAATAAAGGTATCCATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCATTAAAAATTTGGAACCAAAGATCATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGA
CAACAGTTATAAAATGGATTATCCTGAGATGGGTTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGAATGACATCTCGGTCTGGTACA
GATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAACTTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATGC
GTGATGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTTGTTTGTGTGCTTCTGAGCCATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGT
TGACCTGAAAAAAATAACAAACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATTCAGGCCTGCCGTGGTACAGAA
CTGGACTGTGGCATTGAGACAGACAGTGGTGTTGATGATGACATGGCGTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCAC
CTGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGCTTTGTGCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCA
CATTCTTACCCGGGTTAACCGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAACAGATTCCATGTATTGTTTCC
ATGCTCACAAAAGAACTCTATTTTTATCACTAAAGAAATGGTTGGTTGGTGGTTTTTTTTAGTTTGTATGCCAAGTGAGAAGATGGTATATTTGGTACTG
TATTTCCCTCTCATTTTGACCTACTCTCATGCTGCAGAGGGTACTTTAAGACATACTCCTTCCATCAAATAGAACCACTATGAAGCTACCTCAAACTTCC
AGTCAGGTAGTTGCAATTGAATTAAATTAGGAATAAATAAAAATGGATACTGGTGCAGTCATTATGAGAGGCAATGATTGTTAATTTACAGCTTTCATGA
TTAGCAAGTTACAGTGATGCTGTGCTATGAATTTTCAAGTAATTGTGAAAAAGTTAAACATTGAAGTAATGAATTTTTATGATATTCCCCCCACTTAAGA
CTGTGTATTCTAGTTTTGTCAAACTGTAGAAATGATGATGTGGAAGAACTTAGGCATCTGTGGGCATGGTCAAAGGCTCAAACCTTTATTTTAGAATTGA
TATACACGGATGACTTAACTGCATTTTTAGACCATTTATCTGGGATTATGGTTTTGTGATGTTTGTCCTGAACACTTTTGTTGTAAAAAAATAATAATAA
TGTTTAATATTGAGAAAGAAACTAATATTTTATGTGAGAGAAAGTGTGAGCAAACTAACTTGACTTTTAAGGCTAAAACTTAACATTCATAGAGGGGTGG
AGTTTTAACTGTAAGGTGCTACAATGCCCCTGGATCTACCAGCATAAATATCTTCTGATTTGTCCCTATGCATATCAGTTGAGCTTCATATACCAGCAAT
ATATCTGAAGAGCTATTATATAAAAACCCCAAACTGTTGATTATTAGCCAGGTAATGTGAATAAATTCTATAGGAACATATGAAAATACAACTTAAATAA
TAAACAGTGGAATATAAGGAAAGCAATAAATGAATGGGCTGAGCTGCCTGTAACTTGAGAGTAGATGGTTTGAGCCTGAGCAGAGACATGACTCAGCCTG
TTCCATGAAGGCAGAGCCATGGACCACGCAGGAAGGGCCTACAGCCCATTTCTCCATACGCACTGGTATGTGTGGATGATGCTGCCAGGGCGCCATCGCC
AAGTAAGAAAGTGAAGCAAATCAGAAACTTGTGAAGTGGAAATGTTCTAAAGGTGGTGAGGCAATAAAAATCATAGTACTCTTTGTAGCAAAATTCTTAA
GTATGTTATTTTCTGTTGAAGTTTACAATCAAAGGAAAATAGTAATGTTTTATACTGTTTACTGAAAGAAAAAGACCTATGAGCACATAGGACTCTAGAC
GGCATCCAGCCGGAGGCCAGAGCTGAGCCCTCAGCCCGGGAGGCAGGCTCCAGGCCTCAGCAGGTGCGGAGCCGTCACTGCACCAAGTCTCACTGGCTGT
CAGTATGACATTTCACGGGAGATTTCTTGTTGCTCAAAAAATGAGCTCGCATTTGTCAATGACAGTTTCTTTTTTCTTACTAGACCTGTAACTTTTGTAA
ATACACATAGCATGTAATGGTATCTTAAAGTGTGTTTCTATGTGACAATTTTGTACAAATTTGTTATTTTCCATTTTTATTTCAAAATATACATTCAAAC
TTAAAATTACCAA
- CASP3.u.f.5 (forward primer)
- CASP3.u.r.6 (reverse primer)
- Single exon skipping
Frame 0
STSPGGGPRKQCRRGS*RMGAIVRRL*KLIKVSMENTENSVDSKSIKNLEPKIIHGSESMDSGISLD
NSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGT
DVDAANLRETFRNLKYEVRNKNDLTREEIVELM
RDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPV
DLKKITNFFRGDRCRSLTGKPKLFIIQACRGTE
LDCGIETDSGVDDDMACHKIPVEADFLYAYSTA
PGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMH
ILTRVNRKVATEFESFSFDATFHAKKQIPCIVS
MLTKELYFYH*RNGWLVVFFSLYAK*EDGIFGT
VFPSHFDLLSCCRGYFKTYSFHQIEPL*SYLKLP
VR*LQLN*IRNK*KWILVQSL*EAMIVNLQLS*
LASYSDAVL*IFK*L*KS*TLK**IFMIFPPLK
TVYSSFVKL*K**CGRT*ASVGMVKGSNLYFRID
IHG*LNCIFRPFIWDYGFVMFVLNTFVVKK***
CLILRKKLIFYVRESVSKLT*LLRLKLNIHRGV
EF*L*GATMPLDLPA*ISSDLSLCISVELHIPAI
YLKSYYIKTPNC*LLAR*CE*IL*EHMKIQLK*
*TVEYKESNK*MG*AACNLRVDGLSLSRDMTQP
VP*RQSHGPRRKGLQPISPYALVCVDDAARAPSP
SKKVKQIRNL*SGNVLKVVRQ*KS*YSL*QNS*
VCYFLLKFTIKGK**CFILFTERKRPMST*DSR
RHPAGGQS*ALSPGGRLQASAGAEPSLHQVSLAV
SMTFHGRFLVAQKMSSHLSMTVSFFLLDL*LL*
IHIACNGILKCVSM*QFCTNLLFSIFISKYTFK
LKIT
Frame 1
AHLPAAGRGSSADAAPSGWVLL*GGCRS**RYPWRTLKTQWIQNPLKIWNQRSYMEANQWTLEYPW
TTVIKWIILRWVYV**LIIRIFIKALE*HLGLVQ
MSMQQTSGKHSET*NMKSGIKMILHVKKLWN*C
VMFLKKITAKGAVLFVCF*AMVKKE*FLEQMDL
LT*KK*QTFSEGIVVEV*LENPNFSLFRPAVVQN
WTVALRQTVVLMMTWRVIKYQWRPTSCMHTPQH
LVIILGEIQRMAPGSSSRFVPC*NSMPTSLNLC
TFLPGLTERWQQNLSPFPLTLLFMQRNRFHVLFP
CSQKNSIFITKEMVGWWFFLVCMPSEKMVYLVL
YFPLILTYSHAAEGTLRHTPSIK*NHYEATSNF
QSGSCN*IKLGINKNGYWCSHYERQ*LLIYSFHD
*QVTVMLCYEFSSNCEKVKH*SNEFL*YSPHLR
LCILVLSNCRNDDVEELRHLWAWSKAQTFILEL
IYTDDLTAFLDHLSGIMVL*CLS*TLLL*KNNNN
V*Y*ERN*YFM*EKV*AN*LDF*G*NLTFIEGW
SFNCKVLQCPWIYQHKYLLICPYAYQLSFIYQQ
YI*RAII*KPQTVDY*PGNVNKFYRNI*KYNLNN
KQWNIRKAINEWAELPVT*E*MV*A*AET*LSL
FHEGRAMDHAGRAYSPFLHTHWYVWMMLPGRHR
QVRK*SKSETCEVEMF*RW*GNKNHSTLCSKILK
YVIFC*SLQSKENSNVLYCLLKEKDL*AHRTLD
GIQPEARAEPSAREAGSRPQQVRSRHCTKSHWL
SV*HFTGDFLLLKK*ARICQ*QFLFSY*TCNFCK
YT*HVMVS*SVFLCDNFVQICYFPFLFQNIHSN
LKLP
Frame 2
HISRRRAAEAVQTRLLADGCYCEAVVEVNKGIHGEH*KLSGFKIH*KFGTKDHTWKRINGLWNIPG
QQL*NGLS*DGFMYNN***EFS*KHWNDISVWY
RCRCSKPQGNIQKLEI*SQE*K*SYT*RNCGIDA
*CF*RRSQQKEQFCLCASEPW*RRNNFWNKWTC
*PEKNNKLFQRGSL*KSNWKTQTFHYSGLPWYR
TGLWH*DRQWC***HGVS*NTSGGRLLVCILHST
WLLFLAKFKGWLLVHPVALCHAETVCRQA*IYA
HSYPG*PKGGNRI*VLFL*RYFSCKETDSMYCF
HAHKRTLFLSLKKWLVGGFF*FVCQVRRWYIWYC
ISLSF*PTLMLQRVL*DILLPSNRTTMKLPQTS
SQVVAIELN*E*IKMDTGAVIMRGNDC*FTAFM
ISKLQ*CCAMNFQVIVKKLNIEVMNFYDIPPT*D
CVF*FCQTVEMMMWKNLGICGHGQRLKPLF*N*
YTRMT*LHF*TIYLGLWFCDVCPEHFCCKKIII
MFNIEKETNILCERKCEQTNLTFKAKT*HS*RGG
VLTVRCYNAPGSTSINIF*FVPMHIS*ASYTSN
ISEELLYKNPKLLIISQVM*INSIGTYENTT*I
INSGI*GKQ*MNGLSCL*LESRWFEPEQRHDSAC
SMKAEPWTTQEGPTAHFSIRTGMCG*CCQGAIA
K*ESEANQKLVKWKCSKGGEAIKIIVLFVAKFL
SMLFSVEVYNQRKIVMFYTVY*KKKTYEHIGL*T
ASSRRPELSPQPGRQAPGLSRCGAVTAPSLTGC
QYDISREISCCSKNELAFVNDSFFFLTRPVTFV
NTHSM*WYLKVCFYVTILYKFVIFHFYFKIYIQT
*NYQ
Sequence CASP3.cAug05
AGCACATCTCCCGGCGGCGGGCCGCGGAAGCAGTGCAGACGCGGCTCCTAGCGGATGGGTGCTATTGTGAGGCGGTTGTAGAAGAGTTTCGTGAGTGCTCGCAGCTCATACCTGTGGCTGTGTATCCGTGGCCACAGCTGGTTGGCGTCGCCTTGAAATCCCAGGCCGTGAGGAGTTAGCGAGCCCTGCTCACACTCGGC
GCTCTGGTTTTCGGTGGGTGTGCCCTGCACCTGCCTCTTCCCCCATTCTCATTAATAAAGGTATCCATGGAGAACACTGAAAACTCAGTGGATTCAAAAT
CCATTAAAAATTTGGAACCAAAGATCATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGATTATCCTGAGATGGG
TTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGAATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTC
AGAAACTTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATGCGTGATGTTTCTAAAGAAGATCACAGCAAAAGGA
GCAGTTTTGTTTGTGTGCTTCTGAGCCATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACAAACTTTTTCAGAGG
GGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATTCAGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCAGTCGC
TTTGTGCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAACCGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTT
TGACGCTACTTTTCATGCAAAGAAACAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAAAGAAATGGTTGGTTGGTGGTT
TTTTTTAGTTTGTATGCCAAGTGAGAAGATGGTATATTTGGTACTGTATTTCCCTCTCATTTTGACCTACTCTCATGCTGCAGAGGGTACTTTAAGACAT
ACTCCTTCCATCAAATAGAACCACTATGAAGCTACCTCAAACTTCCAGTCAGGTAGTTGCAATTGAATTAAATTAGGAATAAATAAAAATGGATACTGGT
GCAGTCATTATGAGAGGCAATGATTGTTAATTTACAGCTTTCATGATTAGCAAGTTACAGTGATGCTGTGCTATGAATTTTCAAGTAATTGTGAAAAAGT
TAAACATTGAAGTAATGAATTTTTATGATATTCCCCCCACTTAAGACTGTGTATTCTAGTTTTGTCAAACTGTAGAAATGATGATGTGGAAGAACTTAGG
CATCTGTGGGCATGGTCAAAGGCTCAAACCTTTATTTTAGAATTGATATACACGGATGACTTAACTGCATTTTTAGACCATTTATCTGGGATTATGGTTT
TGTGATGTTTGTCCTGAACACTTTTGTTGTAAAAAAATAATAATAATGTTTAATATTGAGAAAGAAACTAATATTTTATGTGAGAGAAAGTGTGAGCAAA
CTAACTTGACTTTTAAGGCTAAAACTTAACATTCATAGAGGGGTGGAGTTTTAACTGTAAGGTGCTACAATGCCCCTGGATCTACCAGCATAAATATCTT
CTGATTTGTCCCTATGCATATCAGTTGAGCTTCATATACCAGCAATATATCTGAAGAGCTATTATATAAAAACCCCAAACTGTTGATTATTAGCCAGGTA
ATGTGAATAAATTCTATAGGAACATATGAAAATACAACTTAAATAATAAACAGTGGAATATAAGGAAAGCAATAAATGAATGGGCTGAGCTGCCTGTAAC
TTGAGAGTAGATGGTTTGAGCCTGAGCAGAGACATGACTCAGCCTGTTCCATGAAGGCAGAGCCATGGACCACGCAGGAAGGGCCTACAGCCCATTTCTC
CATACGCACTGGTATGTGTGGATGATGCTGCCAGGGCGCCATCGCCAAGTAAGAAAGTGAAGCAAATCAGAAACTTGTGAAGTGGAAATGTTCTAAAGGT
GGTGAGGCAATAAAAATCATAGTACTCTTTGTAGCAAAATTCTTAAGTATGTTATTTTCTGTTGAAGTTTACAATCAAAGGAAAATAGTAATGTTTTATA
CTGTTTACTGAAAGAAAAAGACCTATGAGCACATAGGACTCTAGACGGCATCCAGCCGGAGGCCAGAGCTGAGCCCTCAGCCCGGGAGGCAGGCTCCAGG
CCTCAGCAGGTGCGGAGCCGTCACTGCACCAAGTCTCACTGGCTGTCAGTATGACATTTCACGGGAGATTTCTTGTTGCTCAAAAAATGAGCTCGCATTT
GTCAATGACAGTTTCTTTTTTCTTACTAGACCTGTAACTTTTGTAAATACACATAGCATGTAATGGTATCTTAAAGTGTGTTTCTATGTGACAATTTTGT
ACAAATTTGTTATTTTCCATTTTTATTTCAAAATATACATTCAAACTTAAAATTACCAA
- CASP3.u.f.5 (forward primer)
- CASP3.u.r.6 (reverse primer)
- Single exon skipping
Frame 0
STSPGGGPRKQCRRGS*RMGAIVRRL*KSFVSARSSYLWLCIRGHSWLASP*NPRP*GVSEPCSHSA
LWFSVGVPCTCLFPHSH**RYPWRTLKTQWIQN
PLKIWNQRSYMEANQWTLEYPWTTVIKWIILRW
VYV**LIIRIFIKALE*HLGLVQMSMQQTSGKHS
ET*NMKSGIKMILHVKKLWN*CVMFLKKITAKG
AVLFVCF*AMVKKE*FLEQMDLLT*KK*QTFSE
GIVVEV*LENPNFSLFRLLFLAKFKGWLLVHPVA
LCHAETVCRQA*IYAHSYPG*PKGGNRI*VLFL
*RYFSCKETDSMYCFHAHKRTLFLSLKKWLVGG
FF*FVCQVRRWYIWYCISLSF*PTLMLQRVL*DI
LLPSNRTTMKLPQTSSQVVAIELN*E*IKMDTG
AVIMRGNDC*FTAFMISKLQ*CCAMNFQVIVKK
LNIEVMNFYDIPPT*DCVF*FCQTVEMMMWKNLG
ICGHGQRLKPLF*N*YTRMT*LHF*TIYLGLWF
CDVCPEHFCCKKIIIMFNIEKETNILCERKCEQ
TNLTFKAKT*HS*RGGVLTVRCYNAPGSTSINIF
*FVPMHIS*ASYTSNISEELLYKNPKLLIISQV
M*INSIGTYENTT*IINSGI*GKQ*MNGLSCL*
LESRWFEPEQRHDSACSMKAEPWTTQEGPTAHFS
IRTGMCG*CCQGAIAK*ESEANQKLVKWKCSKG
GEAIKIIVLFVAKFLSMLFSVEVYNQRKIVMFY
TVY*KKKTYEHIGL*TASSRRPELSPQPGRQAPG
LSRCGAVTAPSLTGCQYDISREISCCSKNELAF
VNDSFFFLTRPVTFVNTHSM*WYLKVCFYVTIL
YKFVIFHFYFKIYIQT*NYQ
Frame 1
AHLPAAGRGSSADAAPSGWVLL*GGCRRVS*VLAAHTCGCVSVATAGWRRLEIPGREELASPAHTR
RSGFRWVCPAPASSPILINKGIHGEH*KLSGFKI
H*KFGTKDHTWKRINGLWNIPGQQL*NGLS*DG
FMYNN***EFS*KHWNDISVWYRCRCSKPQGNI
QKLEI*SQE*K*SYT*RNCGIDA*CF*RRSQQKE
QFCLCASEPW*RRNNFWNKWTC*PEKNNKLFQR
GSL*KSNWKTQTFHYSGYYSWRNSKDGSWFIQS
LCAMLKQYADKLEFMHILTRVNRKVATEFESFSF
DATFHAKKQIPCIVSMLTKELYFYH*RNGWLVV
FFSLYAK*EDGIFGTVFPSHFDLLSCCRGYFKT
YSFHQIEPL*SYLKLPVR*LQLN*IRNK*KWILV
QSL*EAMIVNLQLS*LASYSDAVL*IFK*L*KS
*TLK**IFMIFPPLKTVYSSFVKL*K**CGRT*
ASVGMVKGSNLYFRIDIHG*LNCIFRPFIWDYGF
VMFVLNTFVVKK***CLILRKKLIFYVRESVSK
LT*LLRLKLNIHRGVEF*L*GATMPLDLPA*IS
SDLSLCISVELHIPAIYLKSYYIKTPNC*LLAR*
CE*IL*EHMKIQLK**TVEYKESNK*MG*AACN
LRVDGLSLSRDMTQPVP*RQSHGPRRKGLQPIS
PYALVCVDDAARAPSPSKKVKQIRNL*SGNVLKV
VRQ*KS*YSL*QNS*VCYFLLKFTIKGK**CFI
LFTERKRPMST*DSRRHPAGGQS*ALSPGGRLQ
ASAGAEPSLHQVSLAVSMTFHGRFLVAQKMSSHL
SMTVSFFLLDL*LL*IHIACNGILKCVSM*QFC
TNLLFSIFISKYTFKLKIT
Frame 2
HISRRRAAEAVQTRLLADGCYCEAVVEEFRECSQLIPVAVYPWPQLVGVALKSQAVRS*RALLTLG
ALVFGGCALHLPLPPFSLIKVSMENTENSVDSK
SIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMG
LCIIINNKNFHKSTGMTSRSGTDVDAANLRETF
RNLKYEVRNKNDLTREEIVELMRDVSKEDHSKR
SSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRG
DRCRSLTGKPKLFIIQVIILGEIQRMAPGSSSR
FVPC*NSMPTSLNLCTFLPGLTERWQQNLSPFP
LTLLFMQRNRFHVLFPCSQKNSIFITKEMVGWWF
FLVCMPSEKMVYLVLYFPLILTYSHAAEGTLRH
TPSIK*NHYEATSNFQSGSCN*IKLGINKNGYW
CSHYERQ*LLIYSFHD*QVTVMLCYEFSSNCEKV
KH*SNEFL*YSPHLRLCILVLSNCRNDDVEELR
HLWAWSKAQTFILELIYTDDLTAFLDHLSGIMV
L*CLS*TLLL*KNNNNV*Y*ERN*YFM*EKV*AN
*LDF*G*NLTFIEGWSFNCKVLQCPWIYQHKYL
LICPYAYQLSFIYQQYI*RAII*KPQTVDY*PG
NVNKFYRNI*KYNLNNKQWNIRKAINEWAELPVT
*E*MV*A*AET*LSLFHEGRAMDHAGRAYSPFL
HTHWYVWMMLPGRHRQVRK*SKSETCEVEMF*R
W*GNKNHSTLCSKILKYVIFC*SLQSKENSNVLY
CLLKEKDL*AHRTLDGIQPEARAEPSAREAGSR
PQQVRSRHCTKSHWLSV*HFTGDFLLLKK*ARI
CQ*QFLFSY*TCNFCKYT*HVMVS*SVFLCDNFV
QICYFPFLFQNIHSNLKLP
Sequence CASP3.aAug05
AGCACATCTCCCGGCGGCGGGCCGCGGAAGCAGTGCAGACGCGGCTCCTAGCGGATGGGTGCTATTGTGAGGCGGTTGTAGAAGAGTTTCGTGAGTGCTCGCAGCTCATACCTGTGGCTGTGTATCCGTGGCCACAGCTGGTTGGCGTCGCCTTGAAATCCCAGGCCGTGAGGAGTTAGCGAGCCCTGCTCACACTCGGC
GCTCTGGTTTTCGGTGGGTGTGCCCTGCACCTGCCTCTTCCCCCATTCTCATTAATAAAGGTATCCATGGAGAACACTGAAAACTCAGTGGATTCAAAAT
CCATTAAAAATTTGGAACCAAAGATCATACATGGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGATTATCCTGAGATGGG
TTTATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGAATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTC
AGAAACTTGAAATATGAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATGCGTGATGTTTCTAAAGAAGATCACAGCAAAAGGA
GCAGTTTTGTTTGTGTGCTTCTGAGCCATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAAAAATAACAAACTTTTTCAGAGG
GGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATTCAGGCCTGCCGTGGTACAGAACTGGACTGTGGCATTGAGACAGACAGTGGTGTT
GATGATGACATGGCGTGTCATAAAATACCAGTGGAGGCCGACTTCTTGTATGCATACTCCACAGCACCTGGTTATTATTCTTGGCGAAATTCAAAGGATG
GCTCCTGGTTCATCCAGTCGCTTTGTGCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAACCGAAAGGTGGCAAC
AGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAACAGATTCCATGTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAA
AGAAATGGTTGGTTGGTGGTTTTTTTTAGTTTGTATGCCAAGTGAGAAGATGGTATATTTGGTACTGTATTTCCCTCTCATTTTGACCTACTCTCATGCT
GCAGAGGGTACTTTAAGACATACTCCTTCCATCAAATAGAACCACTATGAAGCTACCTCAAACTTCCAGTCAGGTAGTTGCAATTGAATTAAATTAGGAA
TAAATAAAAATGGATACTGGTGCAGTCATTATGAGAGGCAATGATTGTTAATTTACAGCTTTCATGATTAGCAAGTTACAGTGATGCTGTGCTATGAATT
TTCAAGTAATTGTGAAAAAGTTAAACATTGAAGTAATGAATTTTTATGATATTCCCCCCACTTAAGACTGTGTATTCTAGTTTTGTCAAACTGTAGAAAT
GATGATGTGGAAGAACTTAGGCATCTGTGGGCATGGTCAAAGGCTCAAACCTTTATTTTAGAATTGATATACACGGATGACTTAACTGCATTTTTAGACC
ATTTATCTGGGATTATGGTTTTGTGATGTTTGTCCTGAACACTTTTGTTGTAAAAAAATAATAATAATGTTTAATATTGAGAAAGAAACTAATATTTTAT
GTGAGAGAAAGTGTGAGCAAACTAACTTGACTTTTAAGGCTAAAACTTAACATTCATAGAGGGGTGGAGTTTTAACTGTAAGGTGCTACAATGCCCCTGG
ATCTACCAGCATAAATATCTTCTGATTTGTCCCTATGCATATCAGTTGAGCTTCATATACCAGCAATATATCTGAAGAGCTATTATATAAAAACCCCAAA
CTGTTGATTATTAGCCAGGTAATGTGAATAAATTCTATAGGAACATATGAAAATACAACTTAAATAATAAACAGTGGAATATAAGGAAAGCAATAAATGA
ATGGGCTGAGCTGCCTGTAACTTGAGAGTAGATGGTTTGAGCCTGAGCAGAGACATGACTCAGCCTGTTCCATGAAGGCAGAGCCATGGACCACGCAGGA
AGGGCCTACAGCCCATTTCTCCATACGCACTGGTATGTGTGGATGATGCTGCCAGGGCGCCATCGCCAAGTAAGAAAGTGAAGCAAATCAGAAACTTGTG
AAGTGGAAATGTTCTAAAGGTGGTGAGGCAATAAAAATCATAGTACTCTTTGTAGCAAAATTCTTAAGTATGTTATTTTCTGTTGAAGTTTACAATCAAA
GGAAAATAGTAATGTTTTATACTGTTTACTGAAAGAAAAAGACCTATGAGCACATAGGACTCTAGACGGCATCCAGCCGGAGGCCAGAGCTGAGCCCTCA
GCCCGGGAGGCAGGCTCCAGGCCTCAGCAGGTGCGGAGCCGTCACTGCACCAAGTCTCACTGGCTGTCAGTATGACATTTCACGGGAGATTTCTTGTTGC
TCAAAAAATGAGCTCGCATTTGTCAATGACAGTTTCTTTTTTCTTACTAGACCTGTAACTTTTGTAAATACACATAGCATGTAATGGTATCTTAAAGTGT
GTTTCTATGTGACAATTTTGTACAAATTTGTTATTTTCCATTTTTATTTCAAAATATACATTCAAACTTAAAATTACCAA
- CASP3.u.f.5 (forward primer)
- CASP3.u.r.6 (reverse primer)
- Single exon skipping
Frame 0
STSPGGGPRKQCRRGS*RMGAIVRRL*KSFVSARSSYLWLCIRGHSWLASP*NPRP*GVSEPCSHSA
LWFSVGVPCTCLFPHSH**RYPWRTLKTQWIQN
PLKIWNQRSYMEANQWTLEYPWTTVIKWIILRW
VYV**LIIRIFIKALE*HLGLVQMSMQQTSGKHS
ET*NMKSGIKMILHVKKLWN*CVMFLKKITAKG
AVLFVCF*AMVKKE*FLEQMDLLT*KK*QTFSE
GIVVEV*LENPNFSLFRPAVVQNWTVALRQTVVL
MMTWRVIKYQWRPTSCMHTPQHLVIILGEIQRM
APGSSSRFVPC*NSMPTSLNLCTFLPGLTERWQ
QNLSPFPLTLLFMQRNRFHVLFPCSQKNSIFITK
EMVGWWFFLVCMPSEKMVYLVLYFPLILTYSHA
AEGTLRHTPSIK*NHYEATSNFQSGSCN*IKLG
INKNGYWCSHYERQ*LLIYSFHD*QVTVMLCYEF
SSNCEKVKH*SNEFL*YSPHLRLCILVLSNCRN
DDVEELRHLWAWSKAQTFILELIYTDDLTAFLD
HLSGIMVL*CLS*TLLL*KNNNNV*Y*ERN*YFM
*EKV*AN*LDF*G*NLTFIEGWSFNCKVLQCPW
IYQHKYLLICPYAYQLSFIYQQYI*RAII*KPQ
TVDY*PGNVNKFYRNI*KYNLNNKQWNIRKAINE
WAELPVT*E*MV*A*AET*LSLFHEGRAMDHAG
RAYSPFLHTHWYVWMMLPGRHRQVRK*SKSETC
EVEMF*RW*GNKNHSTLCSKILKYVIFC*SLQSK
ENSNVLYCLLKEKDL*AHRTLDGIQPEARAEPS
AREAGSRPQQVRSRHCTKSHWLSV*HFTGDFLL
LKK*ARICQ*QFLFSY*TCNFCKYT*HVMVS*SV
FLCDNFVQICYFPFLFQNIHSNLKLP
Frame 1
AHLPAAGRGSSADAAPSGWVLL*GGCRRVS*VLAAHTCGCVSVATAGWRRLEIPGREELASPAHTR
RSGFRWVCPAPASSPILINKGIHGEH*KLSGFKI
H*KFGTKDHTWKRINGLWNIPGQQL*NGLS*DG
FMYNN***EFS*KHWNDISVWYRCRCSKPQGNI
QKLEI*SQE*K*SYT*RNCGIDA*CF*RRSQQKE
QFCLCASEPW*RRNNFWNKWTC*PEKNNKLFQR
GSL*KSNWKTQTFHYSGLPWYRTGLWH*DRQWC
***HGVS*NTSGGRLLVCILHSTWLLFLAKFKGW
LLVHPVALCHAETVCRQA*IYAHSYPG*PKGGN
RI*VLFL*RYFSCKETDSMYCFHAHKRTLFLSL
KKWLVGGFF*FVCQVRRWYIWYCISLSF*PTLML
QRVL*DILLPSNRTTMKLPQTSSQVVAIELN*E
*IKMDTGAVIMRGNDC*FTAFMISKLQ*CCAMN
FQVIVKKLNIEVMNFYDIPPT*DCVF*FCQTVEM
MMWKNLGICGHGQRLKPLF*N*YTRMT*LHF*T
IYLGLWFCDVCPEHFCCKKIIIMFNIEKETNIL
CERKCEQTNLTFKAKT*HS*RGGVLTVRCYNAPG
STSINIF*FVPMHIS*ASYTSNISEELLYKNPK
LLIISQVM*INSIGTYENTT*IINSGI*GKQ*M
NGLSCL*LESRWFEPEQRHDSACSMKAEPWTTQE
GPTAHFSIRTGMCG*CCQGAIAK*ESEANQKLV
KWKCSKGGEAIKIIVLFVAKFLSMLFSVEVYNQ
RKIVMFYTVY*KKKTYEHIGL*TASSRRPELSPQ
PGRQAPGLSRCGAVTAPSLTGCQYDISREISCC
SKNELAFVNDSFFFLTRPVTFVNTHSM*WYLKV
CFYVTILYKFVIFHFYFKIYIQT*NYQ
Frame 2
HISRRRAAEAVQTRLLADGCYCEAVVEEFRECSQLIPVAVYPWPQLVGVALKSQAVRS*RALLTLG
ALVFGGCALHLPLPPFSLIKVSMENTENSVDSK
SIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMG
LCIIINNKNFHKSTGMTSRSGTDVDAANLRETF
RNLKYEVRNKNDLTREEIVELMRDVSKEDHSKR
SSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRG
DRCRSLTGKPKLFIIQACRGTELDCGIETDSGV
DDDMACHKIPVEADFLYAYSTAPGYYSWRNSKD
GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVAT
EFESFSFDATFHAKKQIPCIVSMLTKELYFYH*
RNGWLVVFFSLYAK*EDGIFGTVFPSHFDLLSC
CRGYFKTYSFHQIEPL*SYLKLPVR*LQLN*IRN
K*KWILVQSL*EAMIVNLQLS*LASYSDAVL*I
FK*L*KS*TLK**IFMIFPPLKTVYSSFVKL*K
**CGRT*ASVGMVKGSNLYFRIDIHG*LNCIFRP
FIWDYGFVMFVLNTFVVKK***CLILRKKLIFY
VRESVSKLT*LLRLKLNIHRGVEF*L*GATMPL
DLPA*ISSDLSLCISVELHIPAIYLKSYYIKTPN
C*LLAR*CE*IL*EHMKIQLK**TVEYKESNK*
MG*AACNLRVDGLSLSRDMTQPVP*RQSHGPRR
KGLQPISPYALVCVDDAARAPSPSKKVKQIRNL*
SGNVLKVVRQ*KS*YSL*QNS*VCYFLLKFTIK
GK**CFILFTERKRPMST*DSRRHPAGGQS*AL
SPGGRLQASAGAEPSLHQVSLAVSMTFHGRFLVA
QKMSSHLSMTVSFFLLDL*LL*IHIACNGILKC
VSM*QFCTNLLFSIFISKYTFKLKIT
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