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Sequences

Sequence CAPN3.oAug05

CCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCC
AAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGATGCACGGGAACAAGCAGCACCTGCAGAAGG
ACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCAT
CGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGGAAGTTGAAAATACCATCTCC
GTGGATCGGCCAGTGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGACATGG
AGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCAT
GATTGCGCTCATGGATACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGAAAATTTTCAAACAC
TATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATTCCACCTCAACAACCAGCTCTATGACATCATTA
CCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGAGCTTTTCATGCATTTGA
CAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAG
  • CAPN3.u.f.52 (forward primer)
  • CAPN3.u.r.55 (reverse primer)
  • Multiple exon skipping

Frame 0

PSSTLTATHTVTQTRSEGGCPLGMEESLPSEPS
QVL*ASLGVLPA*GASELRSSCSDAREQAAPAEG
LLPVQRLQGQEQNLHQHAGGVPALPPASQRVRH
RALHLRAPPGGGIHPPGLL*KEEPL*GS*KYHL
RGSASATAWQL*SGK*GTATIPEHFQADSRR*HG
DLCR*AQEGP*HSREQTQGPEDTRVHTGVLP*H
DCAHGYRWLWKAQPAGVPPPLEQD*GLAENFQT
L*HRPVRHHQQLRDAKCSQRRRIPPQQPAL*HHY
HAVRRQTHEHRL*QFHLLLR*AGGHVQSFSCI*
QGWRWYHQAQRSG

Frame 1

PPPRLQPHTQSHRRVLRVAARLGWRNHFPQNPA
KSSRPPWGSFQPEGLRS*GAAVLMHGNKQHLQK
DFFLYNASKARSKTYINMREVSQRFRLPPSEYVI
VPSTYEPHQEGEFILRVFSEKRNLSEEVENTIS
VDRPVPQPGSSDQESEEQQQFRNIFKQIAGDDM
EICADELKKVLNTVVNKHKDLKTHGFTLESCRSM
IALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKH
YDTDQSGTINSYEMRNAVNDAGFHLNNQLYDII
TMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFD
KDGDGIIKLNVLE

Frame 2

LLHAYSHTHSHTDAF*GWLPAWDGGITSLRTQP
SPLGLLGGPSSLRGFGAEEQLF*CTGTSSTCRR
TSSCTTPPRPGAKPTSTCGRCPSASACLPASTS
SCPPPTSPTRRGNSSSGSSLKRGTSLRKLKIPSP
WIGQCHSLAALIRKVRNSNNSGTFSSR*QEMTW
RSVQMSSRRSLTQS*TNTRT*RHTGSHWSPAVA
*LRSWIQMALESSTCRSSTTSGTRLRPGRKFSNT
MTQTSPAPSTATRCEMQSTTQDSTSTTSSMTSL
PCGTQTNT*TSTLTVSSAASLGWRACSELFMHL
TRMEMVSSSSTFW

Sequence CAPN3.nAug05

CCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGG
GAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCT
CTGAAAAGAGGAACCTCTCTGAGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCA
ACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACACAAG
GACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACC
ACCTCTGGAACAAGATTAAGGCCTGGCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAA
CGACGCAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGC
TTCGTTAGGCTGGAGGGCATGTTCAGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAG
  • CAPN3.u.f.52 (forward primer)
  • CAPN3.u.r.55 (reverse primer)
  • Multiple exon skipping

Frame 0

PHLSDAREQAAPAEGLLPVQRLQGQEQNLHQHA
GGVPALPPASQRVRHRALHLRAPPGGGIHPPGLL
*KEEPL*GS*KYHLRGSASATAWQL*SGK*GTA
TIPEHFQADSRR*HGDLCR*AQEGP*HSREQTQ
GPEDTRVHTGVLP*HDCAHGYRWLWKAQPAGVPP
PLEQD*GLAENFQTL*HRPVRHHQQLRDAKCSQ
RRRIPPQQPAL*HHYHAVRRQTHEHRL*QFHLL
LR*AGGHVQSFSCI*QGWRWYHQAQRSG

Frame 1

PISQMHGNKQHLQKDFFLYNASKARSKTYINMR
EVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVF
SEKRNLSEEVENTISVDRPVPQPGSSDQESEEQQ
QFRNIFKQIAGDDMEICADELKKVLNTVVNKHK
DLKTHGFTLESCRSMIALMDTDGSGKLNLQEFH
HLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVN
DAGFHLNNQLYDIITMRYADKHMNIDFDSFICC
FVRLEGMFRAFHAFDKDGDGIIKLNVLE

Frame 2

PSLRCTGTSSTCRRTSSCTTPPRPGAKPTSTCG
RCPSASACLPASTSSCPPPTSPTRRGNSSSGSS
LKRGTSLRKLKIPSPWIGQCHSLAALIRKVRNS
NNSGTFSSR*QEMTWRSVQMSSRRSLTQS*TNTR
T*RHTGSHWSPAVA*LRSWIQMALESSTCRSST
TSGTRLRPGRKFSNTMTQTSPAPSTATRCEMQS
TTQDSTSTTSSMTSLPCGTQTNT*TSTLTVSSAA
SLGWRACSELFMHLTRMEMVSSSSTFW

Sequence CAPN3.dAug05

CACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAAC
TTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCT
CAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCA
CTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCA
CTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCA
CAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTC
TGGAAGAGACCTCCGGAAATTTGCGAGAATCCCCGATTTATCATTGATGGAGCCAACAGAACTGACATCTGTCAAGGAGAGCTAGGGGACTGCTGGTTTC
TCGCAGCCATTGCCTGCCTGACCCTGAACCAGCACCTTCTTTTCCGAGTCATACCCCATGATCAAAGTTTCATCGAAAACTACGCAGGGATCTTCCACTT
CCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAAT
GAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCA
CAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACATGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTC
CATTGATACAATCATTCCGGTTCAGTATGAGACAAGAATGGCCTGCGGGCTGGTCAGAGGTCACGCCTACTCTGTCACGGGGCTGGATGAGGTCCCGTTC
AAAGGTGAGAAAGTGAAGCTGGTGCGGCTGCGGAATCCGTGGGGCCAGGTGGAGTGGAACGGTTCTTGGAGTGATAGATGGAAGGACTGGAGCTTTGTGG
ACAAAGATGAGAAGGCCCGTCTGCAGCACCAGGTCACTGAGGATGGAGAGTTCTGGATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGAT
CTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGTCTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGC
TGCCGCAACTTCCCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCTGGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCT
TCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTTCCCAAAGAGAT
GCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGC
TTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACC
TCTCTGAGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACAT
TTTCAAGCAGATAGCAGGAGATGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACACAC
GGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGA
TTAAGGCCTGGCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATTCCA
CCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAG
GGCATGTTCAGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGTGGCTGCAGCTCACCATGTATGCCTGAACCA
GGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCT
ACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATG
AGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCT
TGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAA
CCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTG
AAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTC
  • CAPN3.u.f.52 (forward primer)
  • CAPN3.u.r.55 (reverse primer)
  • Multiple exon skipping

Frame 0

HSLSLSLWHACCW*ETPKSTLLQKSFSTHFSGE
LMASESQLGF*DGHNLYDLLMGFQL*TGCGHFSL
R*QNYSNFPFAVASFP*R*LYLIFFKKLFLPKP
LAMPTVISASVAPRTAAEPRSPGPVPHPAQSKA
TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLH
KKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFV
WKRPPEICENPRFIIDGANRTDICQGELGDCWF
LAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHF
QFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRN
EFWSALLEKAYAKLHGSYEALKGGNTTEAMEDF
TGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCS
IDTIIPVQYETRMACGLVRGHAYSVTGLDEVPF
KGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFV
DKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEI
CNLTADALQSDKLQTWTVSVNEGRWVRGCSAGG
CRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICS
FLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEM
HGNKQHLQKDFFLYNASKARSKTYINMREVSQR
FRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRN
LSEEVENTISVDRPVPQPGSSDQESEEQQQFRNI
FKQIAGDDMEICADELKKVLNTVVNKHKDLKTH
GFTLESCRSMIALMDTDGSGKLNLQEFHHLWNK
IKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFH
LNNQLYDIITMRYADKHMNIDFDSFICCFVRLE
GMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA*T
RLASSKAMQDHSGFQFHPLFPKPFTSKDPAATPL
QASRHLISHAPPPFYPLPILDRSCLA*PFSKAM
R*EEQTLVPLPCGGKCLPLVRAASVLKRVLLLT
LL*AVCRSTCRWHSAPPCARALHHLHAVPPWARN
QTSTGFYCCGVN*LSGIGLVTLGCPTHKFGCIL
KKADLNKGMCMAG

Frame 1

TLFLSPSGMHAAGRRPPSQHCFRNPLALISQEN
LWLQNHSSVFKMDITCTTF*WAFNFELDVDTFL
SDDRITPTSPLQLLPFLEGSCILFSLKSFFFQSH
LPCRPSLAHLWLQGQRLSPGPQGQFLTRPRARP
LRLGVETQVASIQPSSAAIFLLSE*KRRHSSNF
TRNV*KRKFFMWTLSSHRMRPLSFIARSSPSSSS
GRDLRKFARIPDLSLMEPTELTSVKES*GTAGF
SQPLPA*P*TSTFFSESYPMIKVSSKTTQGSST
SSSGAMESGWTWL*MTACQRTTINWFSPSPTTAM
SSGVLCWRRLMLSSMVPTKL*KVGTPQRPWRTS
QEGWQSFLRSGMLLVTCTRS*RKPSREAPSWAA
PLIQSFRFSMRQEWPAGWSEVTPTLSRGWMRSRS
KVRK*SWCGCGIRGARWSGTVLGVIDGRTGALW
TKMRRPVCSTRSLRMESSGCPMRISSTISQSWR
SATSRPMLCSLTSFRPGQCL*TRAAGYGVALPEA
AATSQILSGPTLSTV*SSWRRTMTLMTRR*FAA
SWWP*CRRTGGRTGS*GPVSSPLASPSTRFPKR
CTGTSSTCRRTSSCTTPPRPGAKPTSTCGRCPSA
SACLPASTSSCPPPTSPTRRGNSSSGSSLKRGT
SLRKLKIPSPWIGQCHSLAALIRKVRNSNNSGT
FSSR*QEMTWRSVQMSSRRSLTQS*TNTRT*RHT
GSHWSPAVA*LRSWIQMALESSTCRSSTTSGTR
LRPGRKFSNTMTQTSPAPSTATRCEMQSTTQDS
TSTTSSMTSLPCGTQTNT*TSTLTVSSAASLGWR
ACSELFMHLTRMEMVSSSSTFWSGCSSPCMPEP
GWPHPKPCRITQDFSFTLYFQSHLPQRTQQLHP
YRLPGTSSVMLLLHFTPYPSLIGHA*PDPLVKQ*
GRKNKPLSLCHVEESACLWSEPPRF*SECSCLP
CSRLSAEAPAGGTQHLLVLEPSITFTLSHHGPG
TKPALGSTAVG*TNSVE*GWLLWAVQLISLAAF*
KKLI*IKACVWLV

Frame 2

LSFSLPLACMLLVGDPQVNIASEIL*HSFLRRT
YGFRITARFLRWT*PVRPSDGLSTLNWMWTLFS
QMTELLQLPLCSCFLSLKVAVSYFL*KAFSSKA
TCHADRH*RICGSKDSG*APVPRASSSPGPEQGH
*GWGWKPKWHLFSHHQPQFSYYRSEREDIRATS
QEMSRKESSLCGP*VPTG*DLSLL*PEVPHPVR
LEETSGNLRESPIYH*WSQQN*HLSRRARGLLVS
RSHCLPDPEPAPSFPSHTP*SKFHRKLRRDLPL
PVLALWRVGGRGYR*LPANVQQSTGFHQVQPPQ
*VLECSAGEGLC*APWFLRSSERWEHHRGHGGLH
RRGGRVF*DQGCS**HVQDHEESHRERLPHGLL
H*YNHSGSV*DKNGLRAGQRSRLLCHGAG*GPV
QR*ESEAGAAAESVGPGGVERFLE**MEGLELCG
QR*EGPSAAPGH*GWRVLDVL*GFHLPFHKVGD
LQPHGRCSAV*QASDLDSVCERGPLGTGLLCRR
LPQLPRYFLDQPSVPSEAPGGGR*P**LGGDLQL
PGGPDAEEPAEGPEARGQSLHHWLRHLRGSQRD
AREQAAPAEGLLPVQRLQGQEQNLHQHAGGVPA
LPPASQRVRHRALHLRAPPGGGIHPPGLL*KEEP
L*GS*KYHLRGSASATAWQL*SGK*GTATIPEH
FQADSRR*HGDLCR*AQEGP*HSREQTQGPEDT
RVHTGVLP*HDCAHGYRWLWKAQPAGVPPPLEQD
*GLAENFQTL*HRPVRHHQQLRDAKCSQRRRIP
PQQPAL*HHYHAVRRQTHEHRL*QFHLLLR*AG
GHVQSFSCI*QGWRWYHQAQRSGVAAAHHVCLNQ
AGLIQSHAGSLRISVSPSISKAIYLKGPSSYTP
TGFQAPHQSCSSSILPPTHP*SVMPSLTL**SN
EVGRTNPCPFAMWRKVPASGPSRLGSEASAPAYL
ALGCLQKHLPVALSTSLC*SPPSPSRCPTMGQE
PNQHWVLLLWGKLTQWNRAGYFGLSNS*VWLHF
EKS*SK*RHVYGW

Sequence CAPN3.jAug05

CCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCC
AAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGATGCACGGGAACAAGCAGCACCTGCAGAAGG
ACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCAT
CGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGGAAGTTGAAAATACCATCTCC
GTGGATCGGCCAGTGAAAAAGAAAAAAACCAAGCCCATCATCTTCGTTTCGGACAGAGCAAACAGCAACAAGGAGCTGGGTGTGGACCAGGAGTCAGAGG
AGGGCAAAGGCAAAACAAGCCCTGATAAGCAAAAGCAGTCCCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAA
CATTTTCAAGCAGATAGCAGGAGATGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACA
CACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACA
AGATTAAGGCCTGGCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATT
CCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTG
GAGGGCATGTTCAGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGTGGCTGCAGCTCACCATGTATGCCTGAA
CCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACC
CCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCA
ATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTA
CCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAG
GAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATT
TTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTC
  • CAPN3.u.f.52 (forward primer)
  • CAPN3.u.r.55 (reverse primer)
  • Multiple exon skipping

Frame 0

PSSTLTATHTVTQTRSEGGCPLGMEESLPSEPS
QVL*ASLGVLPA*GASELRSSCSDAREQAAPAEG
LLPVQRLQGQEQNLHQHAGGVPALPPASQRVRH
RALHLRAPPGGGIHPPGLL*KEEPL*GS*KYHL
RGSASEKEKNQAHHLRFGQSKQQQGAGCGPGVRG
GQRQNKP**AKAVPTATAWQL*SGK*GTATIPE
HFQADSRR*HGDLCR*AQEGP*HSREQTQGPED
TRVHTGVLP*HDCAHGYRWLWKAQPAGVPPPLEQ
D*GLAENFQTL*HRPVRHHQQLRDAKCSQRRRI
PPQQPAL*HHYHAVRRQTHEHRL*QFHLLLR*A
GGHVQSFSCI*QGWRWYHQAQRSGVAAAHHVCLN
QAGLIQSHAGSLRISVSPSISKAIYLKGPSSYT
PTGFQAPHQSCSSSILPPTHP*SVMPSLTL**S
NEVGRTNPCPFAMWRKVPASGPSRLGSEASAPAY
LALGCLQKHLPVALSTSLC*SPPSPSRCPTMGQ
EPNQHWVLLLWGKLTQWNRAGYFGLSNS*VWLH
FEKS*SK*RHVYGW

Frame 1

PPPRLQPHTQSHRRVLRVAARLGWRNHFPQNPA
KSSRPPWGSFQPEGLRS*GAAVLMHGNKQHLQK
DFFLYNASKARSKTYINMREVSQRFRLPPSEYVI
VPSTYEPHQEGEFILRVFSEKRNLSEEVENTIS
VDRPVKKKKTKPIIFVSDRANSNKELGVDQESE
EGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRN
IFKQIAGDDMEICADELKKVLNTVVNKHKDLKT
HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWN
KIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGF
HLNNQLYDIITMRYADKHMNIDFDSFICCFVRL
EGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA*
TRLASSKAMQDHSGFQFHPLFPKPFTSKDPAATP
LQASRHLISHAPPPFYPLPILDRSCLA*PFSKA
MR*EEQTLVPLPCGGKCLPLVRAASVLKRVLLL
TLL*AVCRSTCRWHSAPPCARALHHLHAVPPWAR
NQTSTGFYCCGVN*LSGIGLVTLGCPTHKFGCI
LKKADLNKGMCMAG

Frame 2

LLHAYSHTHSHTDAF*GWLPAWDGGITSLRTQP
SPLGLLGGPSSLRGFGAEEQLF*CTGTSSTCRR
TSSCTTPPRPGAKPTSTCGRCPSASACLPASTS
SCPPPTSPTRRGNSSSGSSLKRGTSLRKLKIPSP
WIGQ*KRKKPSPSSSFRTEQTATRSWVWTRSQR
RAKAKQALISKSSPHSHSLAALIRKVRNSNNSG
TFSSR*QEMTWRSVQMSSRRSLTQS*TNTRT*RH
TGSHWSPAVA*LRSWIQMALESSTCRSSTTSGT
RLRPGRKFSNTMTQTSPAPSTATRCEMQSTTQD
STSTTSSMTSLPCGTQTNT*TSTLTVSSAASLGW
RACSELFMHLTRMEMVSSSSTFWSGCSSPCMPE
PGWPHPKPCRITQDFSFTLYFQSHLPQRTQQLH
PYRLPGTSSVMLLLHFTPYPSLIGHA*PDPLVKQ
*GRKNKPLSLCHVEESACLWSEPPRF*SECSCL
PCSRLSAEAPAGGTQHLLVLEPSITFTLSHHGP
GTKPALGSTAVG*TNSVE*GWLLWAVQLISLAAF
*KKLI*IKACVWLV

Sequence CAPN3.iAug05

CCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGG
GAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCT
CTGAAAAGAGGAACCTCTCTGAGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGAAAAAGAAAAAAACCAAGCCCATCATCTTCGTTTCGGACAG
AGCAAACAGCAACAAGGAGCTGGGTGTGGACCAGGAGTCAGAGGAGGGCAAAGGCAAAACAAGCCCTGATAAGCAAAAGCAGTCCCCACAGCCACAGCCT
GGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGACATGGAGATCTGTGCAGATGAGCTCAAGA
AGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATACAGATGG
CTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACC
ATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACA
TGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAA
GCTCAACGTTCTGGAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGG
GCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCT
GCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTC
  • CAPN3.u.f.52 (forward primer)
  • CAPN3.u.r.55 (reverse primer)
  • Multiple exon skipping

Frame 0

PHLSDAREQAAPAEGLLPVQRLQGQEQNLHQHA
GGVPALPPASQRVRHRALHLRAPPGGGIHPPGLL
*KEEPL*GS*KYHLRGSASEKEKNQAHHLRFGQ
SKQQQGAGCGPGVRGGQRQNKP**AKAVPTATA
WQL*SGK*GTATIPEHFQADSRR*HGDLCR*AQE
GP*HSREQTQGPEDTRVHTGVLP*HDCAHGYRW
LWKAQPAGVPPPLEQD*GLAENFQTL*HRPVRH
HQQLRDAKCSQRRRIPPQQPAL*HHYHAVRRQTH
EHRL*QFHLLLR*AGGHVQSFSCI*QGWRWYHQ
AQRSGGCLQKHLPVALSTSLC*SPPSPSRCPTM
GQEPNQHWVLLLWGKLTQWNRAGYFGLSNS*VWL
HFEKS*SK*RHVYGW

Frame 1

PISQMHGNKQHLQKDFFLYNASKARSKTYINMR
EVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVF
SEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDR
ANSNKELGVDQESEEGKGKTSPDKQKQSPQPQP
GSSDQESEEQQQFRNIFKQIAGDDMEICADELK
KVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDG
SGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGT
INSYEMRNAVNDAGFHLNNQLYDIITMRYADKH
MNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIK
LNVLEAVCRSTCRWHSAPPCARALHHLHAVPPW
ARNQTSTGFYCCGVN*LSGIGLVTLGCPTHKFG
CILKKADLNKGMCMAG

Frame 2

PSLRCTGTSSTCRRTSSCTTPPRPGAKPTSTCG
RCPSASACLPASTSSCPPPTSPTRRGNSSSGSS
LKRGTSLRKLKIPSPWIGQ*KRKKPSPSSSFRT
EQTATRSWVWTRSQRRAKAKQALISKSSPHSHSL
AALIRKVRNSNNSGTFSSR*QEMTWRSVQMSSR
RSLTQS*TNTRT*RHTGSHWSPAVA*LRSWIQM
ALESSTCRSSTTSGTRLRPGRKFSNTMTQTSPAP
STATRCEMQSTTQDSTSTTSSMTSLPCGTQTNT
*TSTLTVSSAASLGWRACSELFMHLTRMEMVSS
SSTFWRLSAEAPAGGTQHLLVLEPSITFTLSHHG
PGTKPALGSTAVG*TNSVE*GWLLWAVQLISLA
AF*KKLI*IKACVWLV

Sequence CAPN3.bAug05

CACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAAC
TTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCT
CAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCA
CTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCA
CTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCA
CAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTC
TGGAAGAGACCTCCGGAAATTTGCGAGAATCCCCGATTTATCATTGATGGAGCCAACAGAACTGACATCTGTCAAGGAGAGCTAGGGGACTGCTGGTTTC
TCGCAGCCATTGCCTGCCTGACCCTGAACCAGCACCTTCTTTTCCGAGTCATACCCCATGATCAAAGTTTCATCGAAAACTACGCAGGGATCTTCCACTT
CCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAAT
GAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCA
CAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACATGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTC
CATTGATGATGGCACGAACATGACCTATGGAACCTCTCCTTCTGGTCTGAACATGGGGGAGTTGATTGCACGGATGGTAAGGAATATGGATAACTCACTG
CTCCAGGACTCAGACCTCGACCCCAGAGGCTCAGATGAAAGACCGACCCGGACAATCATTCCGGTTCAGTATGAGACAAGAATGGCCTGCGGGCTGGTCA
GAGGTCACGCCTACTCTGTCACGGGGCTGGATGAGGTCCCGTTCAAAGGTGAGAAAGTGAAGCTGGTGCGGCTGCGGAATCCGTGGGGCCAGGTGGAGTG
GAACGGTTCTTGGAGTGATAGATGGAAGGACTGGAGCTTTGTGGACAAAGATGAGAAGGCCCGTCTGCAGCACCAGGTCACTGAGGATGGAGAGTTCTGG
ATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGT
CTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCT
GGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGT
CTCTTCACCATTGGCTTCGCCATCTACGAGGTTCCCAAAGAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGG
CCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCA
GGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGAAAAAGAAAAAA
ACCAAGCCCATCATCTTCGTTTCGGACAGAGCAAACAGCAACAAGGAGCTGGGTGTGGACCAGGAGTCAGAGGAGGGCAAAGGCAAAACAAGCCCTGATA
AGCAAAAGCAGTCCCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGA
CATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGT
AGCATGATTGCGCTCATGGATACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGAAAATTTTCA
AACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATTCCACCTCAACAACCAGCTCTATGACAT
CATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGAGCTTTTCATGCA
TTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGC
AGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAG
TCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTC
CCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCA
CCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTG
CTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGC
ATGTGTATGGCTGGTC
  • CAPN3.u.f.52 (forward primer)
  • CAPN3.u.r.55 (reverse primer)
  • Multiple exon skipping

Frame 0

HSLSLSLWHACCW*ETPKSTLLQKSFSTHFSGE
LMASESQLGF*DGHNLYDLLMGFQL*TGCGHFSL
R*QNYSNFPFAVASFP*R*LYLIFFKKLFLPKP
LAMPTVISASVAPRTAAEPRSPGPVPHPAQSKA
TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLH
KKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFV
WKRPPEICENPRFIIDGANRTDICQGELGDCWF
LAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHF
QFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRN
EFWSALLEKAYAKLHGSYEALKGGNTTEAMEDF
TGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCS
IDDGTNMTYGTSPSGLNMGELIARMVRNMDNSL
LQDSDLDPRGSDERPTRTIIPVQYETRMACGLV
RGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEW
NGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFW
MSYEDFIYHFTKLEICNLTADALQSDKLQTWTV
SVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLL
EEDDDPDDSEVICSFLVALMQKNRRKDRKLGAS
LFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASK
ARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQ
EGEFILRVFSEKRNLSEEVENTISVDRPVKKKK
TKPIIFVSDRANSNKELGVDQESEEGKGKTSPD
KQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDD
MEICADELKKVLNTVVNKHKDLKTHGFTLESCR
SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIF
KHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDI
ITMRYADKHMNIDFDSFICCFVRLEGMFRAFHA
FDKDGDGIIKLNVLEWLQLTMYA*TRLASSKAM
QDHSGFQFHPLFPKPFTSKDPAATPLQASRHLIS
HAPPPFYPLPILDRSCLA*PFSKAMR*EEQTLV
PLPCGGKCLPLVRAASVLKRVLLLTLL*AVCRS
TCRWHSAPPCARALHHLHAVPPWARNQTSTGFYC
CGVN*LSGIGLVTLGCPTHKFGCILKKADLNKG
MCMAG

Frame 1

TLFLSPSGMHAAGRRPPSQHCFRNPLALISQEN
LWLQNHSSVFKMDITCTTF*WAFNFELDVDTFL
SDDRITPTSPLQLLPFLEGSCILFSLKSFFFQSH
LPCRPSLAHLWLQGQRLSPGPQGQFLTRPRARP
LRLGVETQVASIQPSSAAIFLLSE*KRRHSSNF
TRNV*KRKFFMWTLSSHRMRPLSFIARSSPSSSS
GRDLRKFARIPDLSLMEPTELTSVKES*GTAGF
SQPLPA*P*TSTFFSESYPMIKVSSKTTQGSST
SSSGAMESGWTWL*MTACQRTTINWFSPSPTTAM
SSGVLCWRRLMLSSMVPTKL*KVGTPQRPWRTS
QEGWQSFLRSGMLLVTCTRS*RKPSREAPSWAA
PLMMART*PMEPLLLV*TWGS*LHGW*GIWITHC
SRTQTSTPEAQMKDRPGQSFRFSMRQEWPAGWS
EVTPTLSRGWMRSRSKVRK*SWCGCGIRGARWS
GTVLGVIDGRTGALWTKMRRPVCSTRSLRMESSG
CPMRISSTISQSWRSATSRPMLCSLTSFRPGQC
L*TRAAGYGVALPEAAATSQILSGPTLSTV*SS
WRRTMTLMTRR*FAASWWP*CRRTGGRTGS*GPV
SSPLASPSTRFPKRCTGTSSTCRRTSSCTTPPR
PGAKPTSTCGRCPSASACLPASTSSCPPPTSPT
RRGNSSSGSSLKRGTSLRKLKIPSPWIGQ*KRKK
PSPSSSFRTEQTATRSWVWTRSQRRAKAKQALI
SKSSPHSHSLAALIRKVRNSNNSGTFSSR*QEM
TWRSVQMSSRRSLTQS*TNTRT*RHTGSHWSPAV
A*LRSWIQMALESSTCRSSTTSGTRLRPGRKFS
NTMTQTSPAPSTATRCEMQSTTQDSTSTTSSMT
SLPCGTQTNT*TSTLTVSSAASLGWRACSELFMH
LTRMEMVSSSSTFWSGCSSPCMPEPGWPHPKPC
RITQDFSFTLYFQSHLPQRTQQLHPYRLPGTSS
VMLLLHFTPYPSLIGHA*PDPLVKQ*GRKNKPLS
LCHVEESACLWSEPPRF*SECSCLPCSRLSAEA
PAGGTQHLLVLEPSITFTLSHHGPGTKPALGST
AVG*TNSVE*GWLLWAVQLISLAAF*KKLI*IKA
CVWLV

Frame 2

LSFSLPLACMLLVGDPQVNIASEIL*HSFLRRT
YGFRITARFLRWT*PVRPSDGLSTLNWMWTLFS
QMTELLQLPLCSCFLSLKVAVSYFL*KAFSSKA
TCHADRH*RICGSKDSG*APVPRASSSPGPEQGH
*GWGWKPKWHLFSHHQPQFSYYRSEREDIRATS
QEMSRKESSLCGP*VPTG*DLSLL*PEVPHPVR
LEETSGNLRESPIYH*WSQQN*HLSRRARGLLVS
RSHCLPDPEPAPSFPSHTP*SKFHRKLRRDLPL
PVLALWRVGGRGYR*LPANVQQSTGFHQVQPPQ
*VLECSAGEGLC*APWFLRSSERWEHHRGHGGLH
RRGGRVF*DQGCS**HVQDHEESHRERLPHGLL
H**WHEHDLWNLSFWSEHGGVDCTDGKEYG*LT
APGLRPRPQRLR*KTDPDNHSGSV*DKNGLRAGQ
RSRLLCHGAG*GPVQR*ESEAGAAAESVGPGGV
ERFLE**MEGLELCGQR*EGPSAAPGH*GWRVL
DVL*GFHLPFHKVGDLQPHGRCSAV*QASDLDSV
CERGPLGTGLLCRRLPQLPRYFLDQPSVPSEAP
GGGR*P**LGGDLQLPGGPDAEEPAEGPEARGQ
SLHHWLRHLRGSQRDAREQAAPAEGLLPVQRLQG
QEQNLHQHAGGVPALPPASQRVRHRALHLRAPP
GGGIHPPGLL*KEEPL*GS*KYHLRGSASEKEK
NQAHHLRFGQSKQQQGAGCGPGVRGGQRQNKP**
AKAVPTATAWQL*SGK*GTATIPEHFQADSRR*
HGDLCR*AQEGP*HSREQTQGPEDTRVHTGVLP
*HDCAHGYRWLWKAQPAGVPPPLEQD*GLAENFQ
TL*HRPVRHHQQLRDAKCSQRRRIPPQQPAL*H
HYHAVRRQTHEHRL*QFHLLLR*AGGHVQSFSC
I*QGWRWYHQAQRSGVAAAHHVCLNQAGLIQSHA
GSLRISVSPSISKAIYLKGPSSYTPTGFQAPHQ
SCSSSILPPTHP*SVMPSLTL**SNEVGRTNPC
PFAMWRKVPASGPSRLGSEASAPAYLALGCLQKH
LPVALSTSLC*SPPSPSRCPTMGQEPNQHWVLL
LWGKLTQWNRAGYFGLSNS*VWLHFEKS*SK*R
HVYGW

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