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Sequences

Sequence CAPN3.qAug05

CCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCA TGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAA GAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTG CCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGT GCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCA GGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAAT ACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAG GGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCG GCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGG CCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGA CCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGA TAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACA CTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAA GCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGG TTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCT TGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTG TCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGT AGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTC ACAAAAAGAAAAAAACCAAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGA CATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGT AGCATGATTGCGCTCATGGATACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGAAAATTTTCA AACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATTCCACCTCAACAACCAGCTCTATGACAT CATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGAGCTTTTCATGCA TTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGC AGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAG TCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTC CCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCA CCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTG CTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGC ATGTGTATGGCTGGTC

CAPN3.u.f.52 (forward primer)
CAPN3.u.r.55 (reverse primer)
Mutually exclusive exon skipping

Frame 0

PFCDIY*APTMFQALS*ALRIE**SKQKEIPAF MELNILT*DNNG*EKHM*HVRFGEVIWSKNKVGK RDRRCWGCLKF*VSMARKATSCPWPPQMSS*PL PL*SLSLEDAPGPWVGGWVMPLGGSEQY*QEPA CLGLAVGDGADMGLVPGVGVFQGFSRGWFWLGCQ EAVHQSKPSTGLLLASGDTETPHVCIPHREVEN TISVDRPVVSGLDLLCEKSRGSPSLTMQGTDGA GENGHWQREWESGLC*AVPPWHCKSYFGMARSNR P*APGAIEAVQGLGNMEEGPGKEKQFEQSEGTR PQEGMTRAAANTGF*DWITLDFTHREKKVSWCR TWC*HLDPPLTSGVTWTISVIPLTQFPTQ*NGDD NVPCKAFVRLHQ*GDVCEVSGTAWALKQRCFFT LYTLQGTFHMCHRDTCKVAER*MGL*SLVFKKG SRGSMGLNDFSEFTELSKWQGWNSHSDSLTPDLG FSAPPR*GQPQAVRSPKSEAQSAVCWALCVEES CDCLGALGCSQLTVLCALWG*RRPMGGQMPL*T VFWAVTVMVIILTLSQCQVSKCLLNDHRRLVLVV GVWGSVLVIWMLVIGVQY*SGPANPKAYGSWHV TKRKKPSHSLAALIRKVRNSNNSGTFSSR*QEM TWRSVQMSSRRSLTQS*TNTRT*RHTGSHWSPAV A*LRSWIQMALESSTCRSSTTSGTRLRPGRKFS NTMTQTSPAPSTATRCEMQSTTQDSTSTTSSMT SLPCGTQTNT*TSTLTVSSAASLGWRACSELFMH LTRMEMVSSSSTFWSGCSSPCMPEPGWPHPKPC RITQDFSFTLYFQSHLPQRTQQLHPYRLPGTSS VMLLLHFTPYPSLIGHA*PDPLVKQ*GRKNKPLS LCHVEESACLWSEPPRF*SECSCLPCSRLSAEA PAGGTQHLLVLEPSITFTLSHHGPGTKPALGST AVG*TNSVE*GWLLWAVQLISLAAF*KKLI*IKA CVWLV

Frame 1

HSVIFIEHLLCSRHCPRH*G*SSEVNRKKSLPS WSLIF*HETIMDRKNICSMLDLER*YGAKIK*G RGIGGVGDA*NFRLAWPGKPHPVPGHHR*AHSPC HSDLCPWKMHQVHG*VAGSCLWGALSNTNKNLR AWAWLSGMVLTWGWFLGLGCSRGSLEAGSGLAA RKPCTRANRPRASCLLLVTLRPHMSVFLTGKLKI PSPWIGQW*VV*IFCAKSPEGPLP*PCRGQMVQ GRMGTGRGNGSLGCAEQSLLGTANPTLAWPEVI GLKHRGPLRQFRGWEIWKRVLERRSNLNNRREQG HRKG*QEPQRTLDSETG*HWISHIEKRK*AGAG PGVDTWILHLPAG*PGQFL*SLSLSFLLSKTGM IMCLARLL*GFINEVMYVKCLAQHGHSNRGAFSH FTPYKVLFTCVIAILARLLRGRWGYNPWCSRKE AEAQWG*MTSLSSQSSVSGRVGTHIQTL*LQT* VFPHLHAEASPRQ*EAQSPKHRVLCVGLCVLRSL VTALGLWAVVS*QSFVLCGDDVGQWEDKCPSEL SSGQ*QSWS*S*P*ASARSPSAF*MTTGDWF*W *VCGDLFWSSGCWSSVCSIDQDLQTQKLMGAGTS QKEKNQATAWQL*SGK*GTATIPEHFQADSRR* HGDLCR*AQEGP*HSREQTQGPEDTRVHTGVLP *HDCAHGYRWLWKAQPAGVPPPLEQD*GLAENFQ TL*HRPVRHHQQLRDAKCSQRRRIPPQQPAL*H HYHAVRRQTHEHRL*QFHLLLR*AGGHVQSFSC I*QGWRWYHQAQRSGVAAAHHVCLNQAGLIQSHA GSLRISVSPSISKAIYLKGPSSYTPTGFQAPHQ SCSSSILPPTHP*SVMPSLTL**SNEVGRTNPC PFAMWRKVPASGPSRLGSEASAPAYLALGCLQKH LPVALSTSLC*SPPSPSRCPTMGQEPNQHWVLL LWGKLTQWNRAGYFGLSNS*VWLHFEKS*SK*R HVYGW

Frame 2

IL*YLLSTYYVPGTVLGTKDRVVK*TERNPCLH GA*YSNMRQ*WIGKTYVAC*IWRGDMEQK*SRE EG*EVLGMLEILG*HGQESHILSLATTDELIAP ATLISVLGRCTRSMGRWLGHAFGGL*AILTRTCV PGLGCRGWC*HGAGSWGWGVPGVL*RLVLAWLP GSRAPEQTVHGPPACFW*H*DPTCLYSSQGS*K YHLRGSASGEWFRSSVRKVQRVPFPDHAGDRWCR GEWALAEGMGVWAVLSSPSLALQILLWHGQK*S ALSTGGH*GSSGAGKYGRGSWKGEAI*TIGGNK ATGRDDKSRSEHWILRLDNIGFHT*RKESKLVPD LVLTLGSSTYQRGDLDNFCNPSHSVSYSVKRG* *CALQGFCEASSMR*CM*SVWHSMGTQTEVLFH TLHLTRYFSHVSSRYLQGC*EVDGVIIPGVQERK QRLNGVE*LL*VHRAQ*VAGLELTFRLSDSRLR FFRTSTLRPAPGSEKPKVRSTECCVLGSVC*GV L*LPWGFGL*SADSPLCSVGMT*ANGRTNAPLNC LLGSDSHGHNPDPEPVPGLQVPSE*PQAIGFSG RCVGICSGHLDAGHRCAVLIRTCKPKSLWELAR HKKKKTKPQPGSSDQESEEQQQFRNIFKQIAGDD MEICADELKKVLNTVVNKHKDLKTHGFTLESCR SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIF KHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDI ITMRYADKHMNIDFDSFICCFVRLEGMFRAFHA FDKDGDGIIKLNVLEWLQLTMYA*TRLASSKAM QDHSGFQFHPLFPKPFTSKDPAATPLQASRHLIS HAPPPFYPLPILDRSCLA*PFSKAMR*EEQTLV PLPCGGKCLPLVRAASVLKRVLLLTLL*AVCRS TCRWHSAPPCARALHHLHAVPPWARNQTSTGFYC CGVN*LSGIGLVTLGCPTHKFGCILKKADLNKG MCMAG

Sequence CAPN3.mAug05

CCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCA TGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAA GAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTG CCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGT GCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCA GGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAAT ACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAG GGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCG GCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGG CCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGA CCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGA TAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACA CTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAA GCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGG TTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCT TGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTG TCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGT AGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTC ACCCCATCATCTTCGTTTCGGACAGAGCAAACAGCAACAAGGAGCTGGGTGTGGACCAGGAGTCAGAGGAGGGCAAAGGCAAAACAAGCCCTGATAAGCA AAAGCAGTCCCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGACATG GAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCA TGATTGCGCTCATGGATACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGAAAATTTTCAAACA CTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATTCCACCTCAACAACCAGCTCTATGACATCATT ACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGAGCTTTTCATGCATTTG ACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGCAGGA TCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAGTCAT GCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTCCCTT TGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCACCTG CCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGT GGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGT GTATGGCTGGTC

CAPN3.u.f.52 (forward primer)
CAPN3.u.r.55 (reverse primer)
Mutually exclusive exon skipping

Frame 0

PFCDIY*APTMFQALS*ALRIE**SKQKEIPAF MELNILT*DNNG*EKHM*HVRFGEVIWSKNKVGK RDRRCWGCLKF*VSMARKATSCPWPPQMSS*PL PL*SLSLEDAPGPWVGGWVMPLGGSEQY*QEPA CLGLAVGDGADMGLVPGVGVFQGFSRGWFWLGCQ EAVHQSKPSTGLLLASGDTETPHVCIPHREVEN TISVDRPVVSGLDLLCEKSRGSPSLTMQGTDGA GENGHWQREWESGLC*AVPPWHCKSYFGMARSNR P*APGAIEAVQGLGNMEEGPGKEKQFEQSEGTR PQEGMTRAAANTGF*DWITLDFTHREKKVSWCR TWC*HLDPPLTSGVTWTISVIPLTQFPTQ*NGDD NVPCKAFVRLHQ*GDVCEVSGTAWALKQRCFFT LYTLQGTFHMCHRDTCKVAER*MGL*SLVFKKG SRGSMGLNDFSEFTELSKWQGWNSHSDSLTPDLG FSAPPR*GQPQAVRSPKSEAQSAVCWALCVEES CDCLGALGCSQLTVLCALWG*RRPMGGQMPL*T VFWAVTVMVIILTLSQCQVSKCLLNDHRRLVLVV GVWGSVLVIWMLVIGVQY*SGPANPKAYGSWHV TPSSSFRTEQTATRSWVWTRSQRRAKAKQALIS KSSPHSHSLAALIRKVRNSNNSGTFSSR*QEMTW RSVQMSSRRSLTQS*TNTRT*RHTGSHWSPAVA *LRSWIQMALESSTCRSSTTSGTRLRPGRKFSN TMTQTSPAPSTATRCEMQSTTQDSTSTTSSMTSL PCGTQTNT*TSTLTVSSAASLGWRACSELFMHL TRMEMVSSSSTFWSGCSSPCMPEPGWPHPKPCR ITQDFSFTLYFQSHLPQRTQQLHPYRLPGTSSVM LLLHFTPYPSLIGHA*PDPLVKQ*GRKNKPLSL CHVEESACLWSEPPRF*SECSCLPCSRLSAEAP AGGTQHLLVLEPSITFTLSHHGPGTKPALGSTAV G*TNSVE*GWLLWAVQLISLAAF*KKLI*IKAC VWLV

Frame 1

HSVIFIEHLLCSRHCPRH*G*SSEVNRKKSLPS WSLIF*HETIMDRKNICSMLDLER*YGAKIK*G RGIGGVGDA*NFRLAWPGKPHPVPGHHR*AHSPC HSDLCPWKMHQVHG*VAGSCLWGALSNTNKNLR AWAWLSGMVLTWGWFLGLGCSRGSLEAGSGLAA RKPCTRANRPRASCLLLVTLRPHMSVFLTGKLKI PSPWIGQW*VV*IFCAKSPEGPLP*PCRGQMVQ GRMGTGRGNGSLGCAEQSLLGTANPTLAWPEVI GLKHRGPLRQFRGWEIWKRVLERRSNLNNRREQG HRKG*QEPQRTLDSETG*HWISHIEKRK*AGAG PGVDTWILHLPAG*PGQFL*SLSLSFLLSKTGM IMCLARLL*GFINEVMYVKCLAQHGHSNRGAFSH FTPYKVLFTCVIAILARLLRGRWGYNPWCSRKE AEAQWG*MTSLSSQSSVSGRVGTHIQTL*LQT* VFPHLHAEASPRQ*EAQSPKHRVLCVGLCVLRSL VTALGLWAVVS*QSFVLCGDDVGQWEDKCPSEL SSGQ*QSWS*S*P*ASARSPSAF*MTTGDWF*W *VCGDLFWSSGCWSSVCSIDQDLQTQKLMGAGTS PHHLRFGQSKQQQGAGCGPGVRGGQRQNKP**A KAVPTATAWQL*SGK*GTATIPEHFQADSRR*H GDLCR*AQEGP*HSREQTQGPEDTRVHTGVLP*H DCAHGYRWLWKAQPAGVPPPLEQD*GLAENFQT L*HRPVRHHQQLRDAKCSQRRRIPPQQPAL*HH YHAVRRQTHEHRL*QFHLLLR*AGGHVQSFSCI* QGWRWYHQAQRSGVAAAHHVCLNQAGLIQSHAG SLRISVSPSISKAIYLKGPSSYTPTGFQAPHQS CSSSILPPTHP*SVMPSLTL**SNEVGRTNPCPF AMWRKVPASGPSRLGSEASAPAYLALGCLQKHL PVALSTSLC*SPPSPSRCPTMGQEPNQHWVLLL WGKLTQWNRAGYFGLSNS*VWLHFEKS*SK*RHV YGW

Frame 2

IL*YLLSTYYVPGTVLGTKDRVVK*TERNPCLH GA*YSNMRQ*WIGKTYVAC*IWRGDMEQK*SRE EG*EVLGMLEILG*HGQESHILSLATTDELIAP ATLISVLGRCTRSMGRWLGHAFGGL*AILTRTCV PGLGCRGWC*HGAGSWGWGVPGVL*RLVLAWLP GSRAPEQTVHGPPACFW*H*DPTCLYSSQGS*K YHLRGSASGEWFRSSVRKVQRVPFPDHAGDRWCR GEWALAEGMGVWAVLSSPSLALQILLWHGQK*S ALSTGGH*GSSGAGKYGRGSWKGEAI*TIGGNK ATGRDDKSRSEHWILRLDNIGFHT*RKESKLVPD LVLTLGSSTYQRGDLDNFCNPSHSVSYSVKRG* *CALQGFCEASSMR*CM*SVWHSMGTQTEVLFH TLHLTRYFSHVSSRYLQGC*EVDGVIIPGVQERK QRLNGVE*LL*VHRAQ*VAGLELTFRLSDSRLR FFRTSTLRPAPGSEKPKVRSTECCVLGSVC*GV L*LPWGFGL*SADSPLCSVGMT*ANGRTNAPLNC LLGSDSHGHNPDPEPVPGLQVPSE*PQAIGFSG RCVGICSGHLDAGHRCAVLIRTCKPKSLWELAR HPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQ KQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDM EICADELKKVLNTVVNKHKDLKTHGFTLESCRS MIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKH YDTDQSGTINSYEMRNAVNDAGFHLNNQLYDII TMRYADKHMNIDFDSFICCFVRLEGMFRAFHAF DKDGDGIIKLNVLEWLQLTMYA*TRLASSKAMQD HSGFQFHPLFPKPFTSKDPAATPLQASRHLISH APPPFYPLPILDRSCLA*PFSKAMR*EEQTLVP LPCGGKCLPLVRAASVLKRVLLLTLL*AVCRSTC RWHSAPPCARALHHLHAVPPWARNQTSTGFYCC GVN*LSGIGLVTLGCPTHKFGCILKKADLNKGM CMAG