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Sequences

Sequence CAPN3.jAug05

CCCTCCTCCACGCTTACAGCCACACACACAGTCACACAGACGCGTTCTGAGGGTGGCTGCCCGCTTGGGATGGAGGAATCACTTCCCTCAGAACCCAGCC
AAGTCCTCTAGGCCTCCTTGGGGGTCCTTCCAGCCTGAGGGGCTTCGGAGCTGAGGAGCAGCTGTTCTGATGCACGGGAACAAGCAGCACCTGCAGAAGG
ACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCAT
CGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGGAAGTTGAAAATACCATCTCC
GTGGATCGGCCAGTGAAAAAGAAAAAAACCAAGCCCATCATCTTCGTTTCGGACAGAGCAAACAGCAACAAGGAGCTGGGTGTGGACCAGGAGTCAGAGG
AGGGCAAAGGCAAAACAAGCCCTGATAAGCAAAAGCAGTCCCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAA
CATTTTCAAGCAGATAGCAGGAGATGACATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACA
CACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACA
AGATTAAGGCCTGGCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATT
CCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTG
GAGGGCATGTTCAGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGTGGCTGCAGCTCACCATGTATGCCTGAA
CCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACC
CCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCA
ATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTA
CCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAG
GAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATT
TTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTC
  • CAPN3.u.f.52 (forward primer)
  • CAPN3.u.r.55 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

PSSTLTATHTVTQTRSEGGCPLGMEESLPSEPS
QVL*ASLGVLPA*GASELRSSCSDAREQAAPAEG
LLPVQRLQGQEQNLHQHAGGVPALPPASQRVRH
RALHLRAPPGGGIHPPGLL*KEEPL*GS*KYHL
RGSASEKEKNQAHHLRFGQSKQQQGAGCGPGVRG
GQRQNKP**AKAVPTATAWQL*SGK*GTATIPE
HFQADSRR*HGDLCR*AQEGP*HSREQTQGPED
TRVHTGVLP*HDCAHGYRWLWKAQPAGVPPPLEQ
D*GLAENFQTL*HRPVRHHQQLRDAKCSQRRRI
PPQQPAL*HHYHAVRRQTHEHRL*QFHLLLR*A
GGHVQSFSCI*QGWRWYHQAQRSGVAAAHHVCLN
QAGLIQSHAGSLRISVSPSISKAIYLKGPSSYT
PTGFQAPHQSCSSSILPPTHP*SVMPSLTL**S
NEVGRTNPCPFAMWRKVPASGPSRLGSEASAPAY
LALGCLQKHLPVALSTSLC*SPPSPSRCPTMGQ
EPNQHWVLLLWGKLTQWNRAGYFGLSNS*VWLH
FEKS*SK*RHVYGW

Frame 1

PPPRLQPHTQSHRRVLRVAARLGWRNHFPQNPA
KSSRPPWGSFQPEGLRS*GAAVLMHGNKQHLQK
DFFLYNASKARSKTYINMREVSQRFRLPPSEYVI
VPSTYEPHQEGEFILRVFSEKRNLSEEVENTIS
VDRPVKKKKTKPIIFVSDRANSNKELGVDQESE
EGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRN
IFKQIAGDDMEICADELKKVLNTVVNKHKDLKT
HGFTLESCRSMIALMDTDGSGKLNLQEFHHLWN
KIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGF
HLNNQLYDIITMRYADKHMNIDFDSFICCFVRL
EGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA*
TRLASSKAMQDHSGFQFHPLFPKPFTSKDPAATP
LQASRHLISHAPPPFYPLPILDRSCLA*PFSKA
MR*EEQTLVPLPCGGKCLPLVRAASVLKRVLLL
TLL*AVCRSTCRWHSAPPCARALHHLHAVPPWAR
NQTSTGFYCCGVN*LSGIGLVTLGCPTHKFGCI
LKKADLNKGMCMAG

Frame 2

LLHAYSHTHSHTDAF*GWLPAWDGGITSLRTQP
SPLGLLGGPSSLRGFGAEEQLF*CTGTSSTCRR
TSSCTTPPRPGAKPTSTCGRCPSASACLPASTS
SCPPPTSPTRRGNSSSGSSLKRGTSLRKLKIPSP
WIGQ*KRKKPSPSSSFRTEQTATRSWVWTRSQR
RAKAKQALISKSSPHSHSLAALIRKVRNSNNSG
TFSSR*QEMTWRSVQMSSRRSLTQS*TNTRT*RH
TGSHWSPAVA*LRSWIQMALESSTCRSSTTSGT
RLRPGRKFSNTMTQTSPAPSTATRCEMQSTTQD
STSTTSSMTSLPCGTQTNT*TSTLTVSSAASLGW
RACSELFMHLTRMEMVSSSSTFWSGCSSPCMPE
PGWPHPKPCRITQDFSFTLYFQSHLPQRTQQLH
PYRLPGTSSVMLLLHFTPYPSLIGHA*PDPLVKQ
*GRKNKPLSLCHVEESACLWSEPPRF*SECSCL
PCSRLSAEAPAGGTQHLLVLEPSITFTLSHHGP
GTKPALGSTAVG*TNSVE*GWLLWAVQLISLAAF
*KKLI*IKACVWLV

Sequence CAPN3.iAug05

CCCCATCTCTCAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGGCCAGGAGCAAAACCTACATCAACATGCGG
GAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCAGGAGGGGGAATTCATCCTCCGGGTCTTCT
CTGAAAAGAGGAACCTCTCTGAGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGAAAAAGAAAAAAACCAAGCCCATCATCTTCGTTTCGGACAG
AGCAAACAGCAACAAGGAGCTGGGTGTGGACCAGGAGTCAGAGGAGGGCAAAGGCAAAACAAGCCCTGATAAGCAAAAGCAGTCCCCACAGCCACAGCCT
GGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGACATGGAGATCTGTGCAGATGAGCTCAAGA
AGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATGGATACAGATGG
CTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGAAAATTTTCAAACACTATGACACAGACCAGTCCGGCACC
ATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGCAGACAAACACA
TGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGAGCTTTTCATGCATTTGACAAGGATGGAGATGGTATCATCAA
GCTCAACGTTCTGGAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGG
GCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCT
GCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTC
  • CAPN3.u.f.52 (forward primer)
  • CAPN3.u.r.55 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

PHLSDAREQAAPAEGLLPVQRLQGQEQNLHQHA
GGVPALPPASQRVRHRALHLRAPPGGGIHPPGLL
*KEEPL*GS*KYHLRGSASEKEKNQAHHLRFGQ
SKQQQGAGCGPGVRGGQRQNKP**AKAVPTATA
WQL*SGK*GTATIPEHFQADSRR*HGDLCR*AQE
GP*HSREQTQGPEDTRVHTGVLP*HDCAHGYRW
LWKAQPAGVPPPLEQD*GLAENFQTL*HRPVRH
HQQLRDAKCSQRRRIPPQQPAL*HHYHAVRRQTH
EHRL*QFHLLLR*AGGHVQSFSCI*QGWRWYHQ
AQRSGGCLQKHLPVALSTSLC*SPPSPSRCPTM
GQEPNQHWVLLLWGKLTQWNRAGYFGLSNS*VWL
HFEKS*SK*RHVYGW

Frame 1

PISQMHGNKQHLQKDFFLYNASKARSKTYINMR
EVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVF
SEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDR
ANSNKELGVDQESEEGKGKTSPDKQKQSPQPQP
GSSDQESEEQQQFRNIFKQIAGDDMEICADELK
KVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDG
SGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGT
INSYEMRNAVNDAGFHLNNQLYDIITMRYADKH
MNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIK
LNVLEAVCRSTCRWHSAPPCARALHHLHAVPPW
ARNQTSTGFYCCGVN*LSGIGLVTLGCPTHKFG
CILKKADLNKGMCMAG

Frame 2

PSLRCTGTSSTCRRTSSCTTPPRPGAKPTSTCG
RCPSASACLPASTSSCPPPTSPTRRGNSSSGSS
LKRGTSLRKLKIPSPWIGQ*KRKKPSPSSSFRT
EQTATRSWVWTRSQRRAKAKQALISKSSPHSHSL
AALIRKVRNSNNSGTFSSR*QEMTWRSVQMSSR
RSLTQS*TNTRT*RHTGSHWSPAVA*LRSWIQM
ALESSTCRSSTTSGTRLRPGRKFSNTMTQTSPAP
STATRCEMQSTTQDSTSTTSSMTSLPCGTQTNT
*TSTLTVSSAASLGWRACSELFMHLTRMEMVSS
SSTFWRLSAEAPAGGTQHLLVLEPSITFTLSHHG
PGTKPALGSTAVG*TNSVE*GWLLWAVQLISLA
AF*KKLI*IKACVWLV

Sequence CAPN3.bAug05

CACTCTCTTTCTCTCTCCCTCTGGCATGCATGCTGCTGGTAGGAGACCCCCAAGTCAACATTGCTTCAGAAATCCTTTAGCACTCATTTCTCAGGAGAAC
TTATGGCTTCAGAATCACAGCTCGGTTTTTAAGATGGACATAACCTGTACGACCTTCTGATGGGCTTTCAACTTTGAACTGGATGTGGACACTTTTCTCT
CAGATGACAGAATTACTCCAACTTCCCCTTTGCAGTTGCTTCCTTTCCTTGAAGGTAGCTGTATCTTATTTTCTTTAAAAAGCTTTTTCTTCCAAAGCCA
CTTGCCATGCCGACCGTCATTAGCGCATCTGTGGCTCCAAGGACAGCGGCTGAGCCCCGGTCCCCAGGGCCAGTTCCTCACCCGGCCCAGAGCAAGGCCA
CTGAGGCTGGGGGTGGAAACCCAAGTGGCATCTATTCAGCCATCATCAGCCGCAATTTTCCTATTATCGGAGTGAAAGAGAAGACATTCGAGCAACTTCA
CAAGAAATGTCTAGAAAAGAAAGTTCTTTATGTGGACCCTGAGTTCCCACCGGATGAGACCTCTCTCTTTTATAGCCAGAAGTTCCCCATCCAGTTCGTC
TGGAAGAGACCTCCGGAAATTTGCGAGAATCCCCGATTTATCATTGATGGAGCCAACAGAACTGACATCTGTCAAGGAGAGCTAGGGGACTGCTGGTTTC
TCGCAGCCATTGCCTGCCTGACCCTGAACCAGCACCTTCTTTTCCGAGTCATACCCCATGATCAAAGTTTCATCGAAAACTACGCAGGGATCTTCCACTT
CCAGTTCTGGCGCTATGGAGAGTGGGTGGACGTGGTTATAGATGACTGCCTGCCAACGTACAACAATCAACTGGTTTTCACCAAGTCCAACCACCGCAAT
GAGTTCTGGAGTGCTCTGCTGGAGAAGGCTTATGCTAAGCTCCATGGTTCCTACGAAGCTCTGAAAGGTGGGAACACCACAGAGGCCATGGAGGACTTCA
CAGGAGGGGTGGCAGAGTTTTTTGAGATCAGGGATGCTCCTAGTGACATGTACAAGATCATGAAGAAAGCCATCGAGAGAGGCTCCCTCATGGGCTGCTC
CATTGATGATGGCACGAACATGACCTATGGAACCTCTCCTTCTGGTCTGAACATGGGGGAGTTGATTGCACGGATGGTAAGGAATATGGATAACTCACTG
CTCCAGGACTCAGACCTCGACCCCAGAGGCTCAGATGAAAGACCGACCCGGACAATCATTCCGGTTCAGTATGAGACAAGAATGGCCTGCGGGCTGGTCA
GAGGTCACGCCTACTCTGTCACGGGGCTGGATGAGGTCCCGTTCAAAGGTGAGAAAGTGAAGCTGGTGCGGCTGCGGAATCCGTGGGGCCAGGTGGAGTG
GAACGGTTCTTGGAGTGATAGATGGAAGGACTGGAGCTTTGTGGACAAAGATGAGAAGGCCCGTCTGCAGCACCAGGTCACTGAGGATGGAGAGTTCTGG
ATGTCCTATGAGGATTTCATCTACCATTTCACAAAGTTGGAGATCTGCAACCTCACGGCCGATGCTCTGCAGTCTGACAAGCTTCAGACCTGGACAGTGT
CTGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGATACTTTCTGGACCAACCCTCAGTACCGTCTGAAGCTCCT
GGAGGAGGACGATGACCCTGATGACTCGGAGGTGATTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGT
CTCTTCACCATTGGCTTCGCCATCTACGAGGTTCCCAAAGAGATGCACGGGAACAAGCAGCACCTGCAGAAGGACTTCTTCCTGTACAACGCCTCCAAGG
CCAGGAGCAAAACCTACATCAACATGCGGGAGGTGTCCCAGCGCTTCCGCCTGCCTCCCAGCGAGTACGTCATCGTGCCCTCCACCTACGAGCCCCACCA
GGAGGGGGAATTCATCCTCCGGGTCTTCTCTGAAAAGAGGAACCTCTCTGAGGAAGTTGAAAATACCATCTCCGTGGATCGGCCAGTGAAAAAGAAAAAA
ACCAAGCCCATCATCTTCGTTTCGGACAGAGCAAACAGCAACAAGGAGCTGGGTGTGGACCAGGAGTCAGAGGAGGGCAAAGGCAAAACAAGCCCTGATA
AGCAAAAGCAGTCCCCACAGCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGA
CATGGAGATCTGTGCAGATGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGT
AGCATGATTGCGCTCATGGATACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGAAAATTTTCA
AACACTATGACACAGACCAGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATTCCACCTCAACAACCAGCTCTATGACAT
CATTACCATGCGGTACGCAGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGAGCTTTTCATGCA
TTTGACAAGGATGGAGATGGTATCATCAAGCTCAACGTTCTGGAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGC
AGGATCACTCAGGATTTCAGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAG
TCATGCTCCTCCTCCATTTTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTC
CCTTTGCCATGTGGAGGAAAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCA
CCTGCCGGTGGCACTCAGCACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTG
CTGTGGGGTAAACTAACTCAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGC
ATGTGTATGGCTGGTC
  • CAPN3.u.f.52 (forward primer)
  • CAPN3.u.r.55 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

HSLSLSLWHACCW*ETPKSTLLQKSFSTHFSGE
LMASESQLGF*DGHNLYDLLMGFQL*TGCGHFSL
R*QNYSNFPFAVASFP*R*LYLIFFKKLFLPKP
LAMPTVISASVAPRTAAEPRSPGPVPHPAQSKA
TEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLH
KKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFV
WKRPPEICENPRFIIDGANRTDICQGELGDCWF
LAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHF
QFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRN
EFWSALLEKAYAKLHGSYEALKGGNTTEAMEDF
TGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCS
IDDGTNMTYGTSPSGLNMGELIARMVRNMDNSL
LQDSDLDPRGSDERPTRTIIPVQYETRMACGLV
RGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEW
NGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFW
MSYEDFIYHFTKLEICNLTADALQSDKLQTWTV
SVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLL
EEDDDPDDSEVICSFLVALMQKNRRKDRKLGAS
LFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASK
ARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQ
EGEFILRVFSEKRNLSEEVENTISVDRPVKKKK
TKPIIFVSDRANSNKELGVDQESEEGKGKTSPD
KQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDD
MEICADELKKVLNTVVNKHKDLKTHGFTLESCR
SMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIF
KHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDI
ITMRYADKHMNIDFDSFICCFVRLEGMFRAFHA
FDKDGDGIIKLNVLEWLQLTMYA*TRLASSKAM
QDHSGFQFHPLFPKPFTSKDPAATPLQASRHLIS
HAPPPFYPLPILDRSCLA*PFSKAMR*EEQTLV
PLPCGGKCLPLVRAASVLKRVLLLTLL*AVCRS
TCRWHSAPPCARALHHLHAVPPWARNQTSTGFYC
CGVN*LSGIGLVTLGCPTHKFGCILKKADLNKG
MCMAG

Frame 1

TLFLSPSGMHAAGRRPPSQHCFRNPLALISQEN
LWLQNHSSVFKMDITCTTF*WAFNFELDVDTFL
SDDRITPTSPLQLLPFLEGSCILFSLKSFFFQSH
LPCRPSLAHLWLQGQRLSPGPQGQFLTRPRARP
LRLGVETQVASIQPSSAAIFLLSE*KRRHSSNF
TRNV*KRKFFMWTLSSHRMRPLSFIARSSPSSSS
GRDLRKFARIPDLSLMEPTELTSVKES*GTAGF
SQPLPA*P*TSTFFSESYPMIKVSSKTTQGSST
SSSGAMESGWTWL*MTACQRTTINWFSPSPTTAM
SSGVLCWRRLMLSSMVPTKL*KVGTPQRPWRTS
QEGWQSFLRSGMLLVTCTRS*RKPSREAPSWAA
PLMMART*PMEPLLLV*TWGS*LHGW*GIWITHC
SRTQTSTPEAQMKDRPGQSFRFSMRQEWPAGWS
EVTPTLSRGWMRSRSKVRK*SWCGCGIRGARWS
GTVLGVIDGRTGALWTKMRRPVCSTRSLRMESSG
CPMRISSTISQSWRSATSRPMLCSLTSFRPGQC
L*TRAAGYGVALPEAAATSQILSGPTLSTV*SS
WRRTMTLMTRR*FAASWWP*CRRTGGRTGS*GPV
SSPLASPSTRFPKRCTGTSSTCRRTSSCTTPPR
PGAKPTSTCGRCPSASACLPASTSSCPPPTSPT
RRGNSSSGSSLKRGTSLRKLKIPSPWIGQ*KRKK
PSPSSSFRTEQTATRSWVWTRSQRRAKAKQALI
SKSSPHSHSLAALIRKVRNSNNSGTFSSR*QEM
TWRSVQMSSRRSLTQS*TNTRT*RHTGSHWSPAV
A*LRSWIQMALESSTCRSSTTSGTRLRPGRKFS
NTMTQTSPAPSTATRCEMQSTTQDSTSTTSSMT
SLPCGTQTNT*TSTLTVSSAASLGWRACSELFMH
LTRMEMVSSSSTFWSGCSSPCMPEPGWPHPKPC
RITQDFSFTLYFQSHLPQRTQQLHPYRLPGTSS
VMLLLHFTPYPSLIGHA*PDPLVKQ*GRKNKPLS
LCHVEESACLWSEPPRF*SECSCLPCSRLSAEA
PAGGTQHLLVLEPSITFTLSHHGPGTKPALGST
AVG*TNSVE*GWLLWAVQLISLAAF*KKLI*IKA
CVWLV

Frame 2

LSFSLPLACMLLVGDPQVNIASEIL*HSFLRRT
YGFRITARFLRWT*PVRPSDGLSTLNWMWTLFS
QMTELLQLPLCSCFLSLKVAVSYFL*KAFSSKA
TCHADRH*RICGSKDSG*APVPRASSSPGPEQGH
*GWGWKPKWHLFSHHQPQFSYYRSEREDIRATS
QEMSRKESSLCGP*VPTG*DLSLL*PEVPHPVR
LEETSGNLRESPIYH*WSQQN*HLSRRARGLLVS
RSHCLPDPEPAPSFPSHTP*SKFHRKLRRDLPL
PVLALWRVGGRGYR*LPANVQQSTGFHQVQPPQ
*VLECSAGEGLC*APWFLRSSERWEHHRGHGGLH
RRGGRVF*DQGCS**HVQDHEESHRERLPHGLL
H**WHEHDLWNLSFWSEHGGVDCTDGKEYG*LT
APGLRPRPQRLR*KTDPDNHSGSV*DKNGLRAGQ
RSRLLCHGAG*GPVQR*ESEAGAAAESVGPGGV
ERFLE**MEGLELCGQR*EGPSAAPGH*GWRVL
DVL*GFHLPFHKVGDLQPHGRCSAV*QASDLDSV
CERGPLGTGLLCRRLPQLPRYFLDQPSVPSEAP
GGGR*P**LGGDLQLPGGPDAEEPAEGPEARGQ
SLHHWLRHLRGSQRDAREQAAPAEGLLPVQRLQG
QEQNLHQHAGGVPALPPASQRVRHRALHLRAPP
GGGIHPPGLL*KEEPL*GS*KYHLRGSASEKEK
NQAHHLRFGQSKQQQGAGCGPGVRGGQRQNKP**
AKAVPTATAWQL*SGK*GTATIPEHFQADSRR*
HGDLCR*AQEGP*HSREQTQGPEDTRVHTGVLP
*HDCAHGYRWLWKAQPAGVPPPLEQD*GLAENFQ
TL*HRPVRHHQQLRDAKCSQRRRIPPQQPAL*H
HYHAVRRQTHEHRL*QFHLLLR*AGGHVQSFSC
I*QGWRWYHQAQRSGVAAAHHVCLNQAGLIQSHA
GSLRISVSPSISKAIYLKGPSSYTPTGFQAPHQ
SCSSSILPPTHP*SVMPSLTL**SNEVGRTNPC
PFAMWRKVPASGPSRLGSEASAPAYLALGCLQKH
LPVALSTSLC*SPPSPSRCPTMGQEPNQHWVLL
LWGKLTQWNRAGYFGLSNS*VWLHFEKS*SK*R
HVYGW

Sequence CAPN3.rAug05

CCATTCTGTGATATTTATTGAGCACCTACTATGTTCCAGGCACTGTCCTAGGCACTAAGGATAGAGTAGTGAAGTAAACAGAAAGAAATCCCTGCCTTCA
TGGAGCTTAATATTCTAACATGAGACAATAATGGATAGGAAAAACATATGTAGCATGTTAGATTTGGAGAGGTGATATGGAGCAAAAATAAAGTAGGGAA
GAGGGATAGGAGGTGTTGGGGATGCTTGAAATTTTAGGTTAGCATGGCCAGGAAAGCCACATCCTGTCCCTGGCCACCACAGATGAGCTCATAGCCCCTG
CCACTCTGATCTCTGTCCTTGGAAGATGCACCAGGTCCATGGGTAGGTGGCTGGGTCATGCCTTTGGGGGGCTCTGAGCAATACTAACAAGAACCTGCGT
GCCTGGGCTTGGCTGTCGGGGATGGTGCTGACATGGGGCTGGTTCCTGGGGTTGGGGTGTTCCAGGGGTTCTCTAGAGGCTGGTTCTGGCTTGGCTGCCA
GGAAGCCGTGCACCAGAGCAAACCGTCCACGGGCCTCCTGCTTGCTTCTGGTGACACTGAGACCCCACATGTCTGTATTCCTCACAGGGAAGTTGAAAAT
ACCATCTCCGTGGATCGGCCAGTGGTGAGTGGTTTAGATCTTCTGTGCGAAAAGTCCAGAGGGTCCCCTTCCCTGACCATGCAGGGGACAGATGGTGCAG
GGGAGAATGGGCACTGGCAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCG
GCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGG
CCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGA
CCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGACAATTTCTGTAATCCCTCTCACTCAGTTTCCTACTCAGTAAAACGGGGATGA
TAATGTGCCTTGCAAGGCTTTTGTGAGGCTTCATCAATGAGGTGATGTATGTGAAGTGTCTGGCACAGCATGGGCACTCAAACAGAGGTGCTTTTTCACA
CTTTACACCTTACAAGGTACTTTTCACATGTGTCATCGCGATACTTGCAAGGTTGCTGAGAGGTAGATGGGGTTATAATCCCTGGTGTTCAAGAAAGGAA
GCAGAGGCTCAATGGGGTTGAATGACTTCTCTGAGTTCACAGAGCTCAGTAAGTGGCAGGGTTGGAACTCACATTCAGACTCTCTGACTCCAGACTTAGG
TTTTTCCGCACCTCCACGCTGAGGCCAGCCCCAGGCAGTGAGAAGCCCAAAGTCCGAAGCACAGAGTGCTGTGTGTTGGGCTCTGTGTGTTGAGGAGTCT
TGTGACTGCCTTGGGGCTTTGGGCTGTAGTCAGCTGACAGTCCTTTGTGCTCTGTGGGGATGACGTAGGCCAATGGGAGGACAAATGCCCCTCTGAACTG
TCTTCTGGGCAGTGACAGTCATGGTCATAATCCTGACCCTGAGCCAGTGCCAGGTCTCCAAGTGCCTTCTGAATGACCACAGGCGATTGGTTTTAGTGGT
AGGTGTGTGGGGATCTGTTCTGGTCATCTGGATGCTGGTCATCGGTGTGCAGTATTGATCAGGACCTGCAAACCCAAAAGCTTATGGGAGCTGGCACGTC
ACCCACAGCCTGGCAGCTCTGATCAGGAAAGTGAGGAACAGCAACAATTCCGGAACATTTTCAAGCAGATAGCAGGAGATGACATGGAGATCTGTGCAGA
TGAGCTCAAGAAGGTCCTTAACACAGTCGTGAACAAACACAAGGACCTGAAGACACACGGGTTCACACTGGAGTCCTGCCGTAGCATGATTGCGCTCATG
GATACAGATGGCTCTGGAAAGCTCAACCTGCAGGAGTTCCACCACCTCTGGAACAAGATTAAGGCCTGGCAGAAAATTTTCAAACACTATGACACAGACC
AGTCCGGCACCATCAACAGCTACGAGATGCGAAATGCAGTCAACGACGCAGGATTCCACCTCAACAACCAGCTCTATGACATCATTACCATGCGGTACGC
AGACAAACACATGAACATCGACTTTGACAGTTTCATCTGCTGCTTCGTTAGGCTGGAGGGCATGTTCAGAGCTTTTCATGCATTTGACAAGGATGGAGAT
GGTATCATCAAGCTCAACGTTCTGGAGTGGCTGCAGCTCACCATGTATGCCTGAACCAGGCTGGCCTCATCCAAAGCCATGCAGGATCACTCAGGATTTC
AGTTTCACCCTCTATTTCCAAAGCCATTTACCTCAAAGGACCCAGCAGCTACACCCCTACAGGCTTCCAGGCACCTCATCAGTCATGCTCCTCCTCCATT
TTACCCCCTACCCATCCTTGATCGGTCATGCCTAGCCTGACCCTTTAGTAAAGCAATGAGGTAGGAAGAACAAACCCTTGTCCCTTTGCCATGTGGAGGA
AAGTGCCTGCCTCTGGTCCGAGCCGCCTCGGTTCTGAAGCGAGTGCTCCTGCTTACCTTGCTCTAGGCTGTCTGCAGAAGCACCTGCCGGTGGCACTCAG
CACCTCCTTGTGCTAGAGCCCTCCATCACCTTCACGCTGTCCCACCATGGGCCAGGAACCAAACCAGCACTGGGTTCTACTGCTGTGGGGTAAACTAACT
CAGTGGAATAGGGCTGGTTACTTTGGGCTGTCCAACTCATAAGTTTGGCTGCATTTTGAAAAAAGCTGATCTAAATAAAGGCATGTGTATGGCTGGTC
  • CAPN3.u.f.52 (forward primer)
  • CAPN3.u.r.55 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

PFCDIY*APTMFQALS*ALRIE**SKQKEIPAF
MELNILT*DNNG*EKHM*HVRFGEVIWSKNKVGK
RDRRCWGCLKF*VSMARKATSCPWPPQMSS*PL
PL*SLSLEDAPGPWVGGWVMPLGGSEQY*QEPA
CLGLAVGDGADMGLVPGVGVFQGFSRGWFWLGCQ
EAVHQSKPSTGLLLASGDTETPHVCIPHREVEN
TISVDRPVVSGLDLLCEKSRGSPSLTMQGTDGA
GENGHWQREWESGLC*AVPPWHCKSYFGMARSNR
P*APGAIEAVQGLGNMEEGPGKEKQFEQSEGTR
PQEGMTRAAANTGF*DWITLDFTHREKKVSWCR
TWC*HLDPPLTSGVTWTISVIPLTQFPTQ*NGDD
NVPCKAFVRLHQ*GDVCEVSGTAWALKQRCFFT
LYTLQGTFHMCHRDTCKVAER*MGL*SLVFKKG
SRGSMGLNDFSEFTELSKWQGWNSHSDSLTPDLG
FSAPPR*GQPQAVRSPKSEAQSAVCWALCVEES
CDCLGALGCSQLTVLCALWG*RRPMGGQMPL*T
VFWAVTVMVIILTLSQCQVSKCLLNDHRRLVLVV
GVWGSVLVIWMLVIGVQY*SGPANPKAYGSWHV
THSLAALIRKVRNSNNSGTFSSR*QEMTWRSVQ
MSSRRSLTQS*TNTRT*RHTGSHWSPAVA*LRSW
IQMALESSTCRSSTTSGTRLRPGRKFSNTMTQT
SPAPSTATRCEMQSTTQDSTSTTSSMTSLPCGT
QTNT*TSTLTVSSAASLGWRACSELFMHLTRMEM
VSSSSTFWSGCSSPCMPEPGWPHPKPCRITQDF
SFTLYFQSHLPQRTQQLHPYRLPGTSSVMLLLH
FTPYPSLIGHA*PDPLVKQ*GRKNKPLSLCHVEE
SACLWSEPPRF*SECSCLPCSRLSAEAPAGGTQ
HLLVLEPSITFTLSHHGPGTKPALGSTAVG*TN
SVE*GWLLWAVQLISLAAF*KKLI*IKACVWLV

Frame 1

HSVIFIEHLLCSRHCPRH*G*SSEVNRKKSLPS
WSLIF*HETIMDRKNICSMLDLER*YGAKIK*G
RGIGGVGDA*NFRLAWPGKPHPVPGHHR*AHSPC
HSDLCPWKMHQVHG*VAGSCLWGALSNTNKNLR
AWAWLSGMVLTWGWFLGLGCSRGSLEAGSGLAA
RKPCTRANRPRASCLLLVTLRPHMSVFLTGKLKI
PSPWIGQW*VV*IFCAKSPEGPLP*PCRGQMVQ
GRMGTGRGNGSLGCAEQSLLGTANPTLAWPEVI
GLKHRGPLRQFRGWEIWKRVLERRSNLNNRREQG
HRKG*QEPQRTLDSETG*HWISHIEKRK*AGAG
PGVDTWILHLPAG*PGQFL*SLSLSFLLSKTGM
IMCLARLL*GFINEVMYVKCLAQHGHSNRGAFSH
FTPYKVLFTCVIAILARLLRGRWGYNPWCSRKE
AEAQWG*MTSLSSQSSVSGRVGTHIQTL*LQT*
VFPHLHAEASPRQ*EAQSPKHRVLCVGLCVLRSL
VTALGLWAVVS*QSFVLCGDDVGQWEDKCPSEL
SSGQ*QSWS*S*P*ASARSPSAF*MTTGDWF*W
*VCGDLFWSSGCWSSVCSIDQDLQTQKLMGAGTS
PTAWQL*SGK*GTATIPEHFQADSRR*HGDLCR
*AQEGP*HSREQTQGPEDTRVHTGVLP*HDCAH
GYRWLWKAQPAGVPPPLEQD*GLAENFQTL*HRP
VRHHQQLRDAKCSQRRRIPPQQPAL*HHYHAVR
RQTHEHRL*QFHLLLR*AGGHVQSFSCI*QGWR
WYHQAQRSGVAAAHHVCLNQAGLIQSHAGSLRIS
VSPSISKAIYLKGPSSYTPTGFQAPHQSCSSSI
LPPTHP*SVMPSLTL**SNEVGRTNPCPFAMWR
KVPASGPSRLGSEASAPAYLALGCLQKHLPVALS
TSLC*SPPSPSRCPTMGQEPNQHWVLLLWGKLT
QWNRAGYFGLSNS*VWLHFEKS*SK*RHVYGW

Frame 2

IL*YLLSTYYVPGTVLGTKDRVVK*TERNPCLH
GA*YSNMRQ*WIGKTYVAC*IWRGDMEQK*SRE
EG*EVLGMLEILG*HGQESHILSLATTDELIAP
ATLISVLGRCTRSMGRWLGHAFGGL*AILTRTCV
PGLGCRGWC*HGAGSWGWGVPGVL*RLVLAWLP
GSRAPEQTVHGPPACFW*H*DPTCLYSSQGS*K
YHLRGSASGEWFRSSVRKVQRVPFPDHAGDRWCR
GEWALAEGMGVWAVLSSPSLALQILLWHGQK*S
ALSTGGH*GSSGAGKYGRGSWKGEAI*TIGGNK
ATGRDDKSRSEHWILRLDNIGFHT*RKESKLVPD
LVLTLGSSTYQRGDLDNFCNPSHSVSYSVKRG*
*CALQGFCEASSMR*CM*SVWHSMGTQTEVLFH
TLHLTRYFSHVSSRYLQGC*EVDGVIIPGVQERK
QRLNGVE*LL*VHRAQ*VAGLELTFRLSDSRLR
FFRTSTLRPAPGSEKPKVRSTECCVLGSVC*GV
L*LPWGFGL*SADSPLCSVGMT*ANGRTNAPLNC
LLGSDSHGHNPDPEPVPGLQVPSE*PQAIGFSG
RCVGICSGHLDAGHRCAVLIRTCKPKSLWELAR
HPQPGSSDQESEEQQQFRNIFKQIAGDDMEICAD
ELKKVLNTVVNKHKDLKTHGFTLESCRSMIALM
DTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTD
QSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYA
DKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGD
GIIKLNVLEWLQLTMYA*TRLASSKAMQDHSGF
QFHPLFPKPFTSKDPAATPLQASRHLISHAPPPF
YPLPILDRSCLA*PFSKAMR*EEQTLVPLPCGG
KCLPLVRAASVLKRVLLLTLL*AVCRSTCRWHS
APPCARALHHLHAVPPWARNQTSTGFYCCGVN*L
SGIGLVTLGCPTHKFGCILKKADLNKGMCMAG

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