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Sequences

Sequence APLP2.hAug05

GCTACAGATCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGTCGCTTTGTTACACCT TTCAAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAGCGGATGGAGGTGTGTGAGAATCACC AGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGCATGCTGCTCCCATGTGGGGTAGACCAGTTCCATGG CACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAAGAGGAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAG GAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGATCTGGAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATAATGAGCATG CTCGCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAA CCTCCCCAAAGCAGAGAGGCAGACTCTGATTCAGCACTTCCAAGCCATGGTTAAAGCTTTAGAGAAGGAAGCAGCCAGTGAGAAGCAGCAGCTGGTGGAG ACCCACCTGGCCCGAGTGGAAGCTATGCTGAATGACCGCCGTCGGATGGCTCTGGAGAACTACCTGGCTGCCTTGCAGTCTGACCCGCCACGGCCTCATC GCATTCTCCAGGCCTTACGGCGTTATGTCCGTGCTGAGAACAAAGATCGCTTACATACCATCCGTCATTACCAGCATGTGTTGGCTGTTGACCCAGAAAA GGCGGCCCAGATGAAATCCCAGGTGATGACACATCTCCACGTGATTGAAGAAAGGAGGAACCAAAGCCTCTCTCTGCTCTACAAAGTACCTTATGTAGCC CAAGAAATTCAAGAGGAAATTGGATCTGGAGTGGGAGAGCAGGATGGGGGACTGATCGGTGCCGAAGAGAAAGTGATTAACAGTAAGAATAAAGTGGATG AAAACATGGTCATTGACGAGACTCTGGATGTTAAGGAAATGATTTTCAATGCCGAGAGAGTTGGAGGCCTCGAGGAAGAGCGGGAATCCGTGGGCCCACT GCGGGAGGACTTCAGTCTGAGTAGCAGTGCTCTCATTGGCCTGCTGGTCATCGCAGTGGCCATTGCCACGGTCATCGTCATCAGCCTGGTGATGCTGAGG AAGAGGCAGTATGGCACCATCAGCCACGGGATCGTGGAGGTTGATCCAATGCTCACCCCAGAAGAGCGTCACCTGAACAAGATGCAGAACCATGGCTATG AGAACCCCACCTACAAATACCTGGAGCAGATGCAGATTTAGGTGGCAGGGAGCGCGGCAGCCCTGGCGGAGGGATGCAGGTGGGCCGGAAGATCCCACGA TTCCGATCGACTGCCAAGCAGCAGCCGCTGCCAGGGGCTGCGTCTGACATCCTGACCTCCTGGACTGTAGGACTATATAAAGTACTACTGTAGAACTGCA ATTTCCATTCTTTTAAATGGGTGAAAAATGGTAATATAACAATATATGATATATAAACCTTAAATGAAAAAAATGATCTATTGCAGATATTTGATGTAGT TTTCTTTTTTAAATTAATCAGAAACCCCACTTCCATTGTATTGTCTGACACATGCTCTCAATATATAATAAATGGGAAATGTCGATTTTCAATAATAGAC TTATATGCAGGCTGTCGTTCCGGTTATGTTGTGTAAGTCAACTCTTCAGCCTCATTCACTGTCCTGGCTTTTATTTAAAGAAAAAAAAGGCAGTATTCCC TTTTTAAATGAGCTTTCAGGAAGTTGCTGAGAAATGGGGTGGAATAGGGAACTGTAATGGCCACTGAAGCACGTGAGAGACCCTCGCAAAATGATGTGAA AGGACCAGTTTCTTGAAGTCCAGTGTTTCCACGGCTGGATACCTGTGTGTCTCCATAAAAGTCCTGTCACCAAGGACGTTAAAGGCATTTTATTCCAGCG TCTTCTAGAGAGCTTAGTGTATACAGATGAGGGTGTCCGCTGCTGCTTTCCTTCGGAATCCAGTGCTTCCACAGAGATTAGCCTGTAGCTTATATTTGAC ATTCTTCACTGTCTGTTGTTTACCTACCGTAGCTTTTTACCGTTCACTTCCCCTTCCAACTATGTCCAGATGTGCAGGCTCCTCCTCTCTGGACTTTCTC CAAAGGCACTGACCCTCGGCCTCTACTTTGTCCCCTCACCTCCACCCCCTCCTGTCACCGGCCTTGTGACATTCACTCAGAGAAGACCACACCAAGGAGG CGGCCGCTGGCCCAGGAGAGAACACGGGGAGGTTTGTTTGTGTGAAAGGAAAGTAGTCCAGGCTGTCCCTGAAACTGAGTCTGTGGACACTGTGGAAAGC TTTGAACAATTGTGTTTTCGTCACAGGAGTCTTTGTAATGCTTGTACAGTTGATGTCGATGCTCACTGCTTCTGCTTTTTCTTTCTTTTTATTTTAAATC TGAAGGTTCTGGTAACCTGTGGTGTATTTTTATTTTCCTGTGACTGTTTTTGTTTTGTTTTTTTCCTTTTTCCTCCCCTTTGACCCTATTCATGTCTCTA CCCACTATGCACAGATTAAACTTCACCTACAAACTCCTTAATATGATCTGTGGAGAATGTACACAGTTTAAACACATCAATAAATACTTTAACTTCCACC GAGACT

APLP2-F1 (forward primer)
APLP2-R1 (reverse primer)
Alternative donor and acceptor

Frame 0

ATDHKCDGGKPAG*Y*QLVPEGQKAMQESLCYT FQVSRG*ICK*CPASSRKVPVFPQRADGGV*ESP ALAHGSQRGMSDSGNDLI*LRHAAPMWGRPVPW H*ICVLPSDKDYWICVKRRGRGR*RGRGRGR*R GRL*CL*K*ISY*SRSGRLHRSSCG*G**G**AC SLPEG*GAAGDSAPQPNGQGKEGMGRGRASS*E PPQSREADSDSALPSHG*SFREGSSQ*EAAAGG DPPGPSGSYAE*PPSDGSGELPGCLAV*PATASS HSPGLTALCPC*EQRSLTYHPSLPACVGC*PRK GGPDEIPGDDTSPRD*RKEEPKPLSALQSTLCS PRNSRGNWIWSGRAGWGTDRCRRESD*Q*E*SG* KHGH*RDSGC*GNDFQCRESWRPRGRAGIRGPT AGGLQSE*QCSHWPAGHRSGHCHGHRHQPGDAE EEAVWHHQPRDRGG*SNAHPRRASPEQDAEPWL* EPHLQIPGADADLGGRERGSPGGGMQVGRKIPR FRSTAKQQPLPGAASDILTSWTVGLYKVLL*NC NFHSFKWVKNGNITIYDI*TLNEKNDLLQIFDVV FFFKLIRNPTSIVLSDTCSQYIINGKCRFSIID LYAGCRSGYVV*VNSSASFTVLAFI*RKKRQYS LFK*AFRKLLRNGVE*GTVMATEARERPSQNDVK GPVS*SPVFPRLDTCVSP*KSCHQGR*RHFIPA SSRELSVYR*GCPLLLSFGIQCFHRD*PVAYI* HSSLSVVYLP*LFTVHFPFQLCPDVQAPPLWTFS KGTDPRPLLCPLTSTPSCHRPCDIHSEKTTPRR RPLAQERTRGGLFV*KESSPGCP*N*VCGHCGK L*TIVFSSQESL*CLYS*CRCSLLLLFLSFYFKS EGSGNLWCIFIFL*LFLFCFFPFSSPLTLFMSL PTMHRLNFTYKLLNMICGECTQFKHINKYFNFH RD

Frame 1

LQITNVMEANQRVSIDNWCRRDKKQCKSRFVTP FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENH QHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHG TEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEE EDYDVYKSEFPTEADLEDFTEAAVDEDDEDNEH ARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKN LPKAERQTLIQHFQAMVKALEKEAASEKQQLVE THLARVEAMLNDRRRMALENYLAALQSDPPRPH RILQALRRYVRAENKDRLHTIRHYQHVLAVDPEK AAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVA QEIQEEIGSGVGEQDGGLIGAEEKVINSKNKVD ENMVIDETLDVKEMIFNAERVGGLEEERESVGPL REDFSLSSSALIGLLVIAVAIATVIVISLVMLR KRQYGTISHGIVEVDPMLTPEERHLNKMQNHGY ENPTYKYLEQMQI*VAGSAAALAEGCRWAGRSHD SDRLPSSSRCQGLRLTS*PPGL*DYIKYYCRTA ISILLNG*KMVI*QYMIYKP*MKKMIYCRYLM* FSFLN*SETPLPLYCLTHALNI**MGNVDFQ**T YMQAVVPVMLCKSTLQPHSLSWLLFKEKKGSIP FLNELSGSC*EMGWNREL*WPLKHVRDPRKMM* KDQFLEVQCFHGWIPVCLHKSPVTKDVKGILFQR LLESLVYTDEGVRCCFPSESSASTEISL*LIFD ILHCLLFTYRSFLPFTSPSNYVQMCRLLLSGLS PKALTLGLYFVPSPPPPPVTGLVTFTQRRPHQGG GRWPRREHGEVCLCERKVVQAVPETESVDTVES FEQLCFRHRSLCNACTVDVDAHCFCFFFLFILN LKVLVTCGVFLFSCDCFCFVFFLFPPL*PYSCLY PLCTD*TSPTNSLI*SVENVHSLNTSINTLTST ET

Frame 2

YRSQM*WRQTSGLVLTTGAGGTKSNARVALLHL SSVSWVNL*VMSC*FQKSASFSTKSGWRCVRIT STGTR*SKRHV*LRE*PYIATACCSHVG*TSSM ALNMCAALRQRLLDLCQKKRKRKMKRKRKRKMKR KTMMFIKVNFLLKQIWKTSQKQLWMRMMRIMSM LASRRLRSSWRFGTATEWTG*RRNGKRQSFKLR TSPKQRGRL*FSTSKPWLKL*RRKQPVRSSSWWR PTWPEWKLC*MTAVGWLWRTTWLPCSLTRHGLI AFSRPYGVMSVLRTKIAYIPSVITSMCWLLTQK RRPR*NPR**HIST*LKKGGTKASLCSTKYLM*P KKFKRKLDLEWESRMGD*SVPKRK*LTVRIKWM KTWSLTRLWMLRK*FSMPRELEASRKSGNPWAH CGRTSV*VAVLSLACWSSQWPLPRSSSSAW*C*G RGSMAPSATGSWRLIQCSPQKSVT*TRCRTMAM RTPPTNTWSRCRFRWQGARQPWRRDAGGPEDPT IPIDCQAAAAARGCV*HPDLLDCRTI*STTVELQ FPFF*MGEKW*YNNI*YINLK*KK*SIADI*CS FLF*INQKPHFHCIV*HMLSIYNKWEMSIFNNR LICRLSFRLCCVSQLFSLIHCPGFYLKKKKAVFP F*MSFQEVAEKWGGIGNCNGH*ST*ETLAK*CE RTSFLKSSVSTAGYLCVSIKVLSPRTLKAFYSS VF*RA*CIQMRVSAAAFLRNPVLPQRLACSLYLT FFTVCCLPTVAFYRSLPLPTMSRCAGSSSLDFL QRH*PSASTLSPHLHPLLSPAL*HSLREDHTKE AAAGPGENTGRFVCVKGK*SRLSLKLSLWTLWKA LNNCVFVTGVFVMLVQLMSMLTASAFSFFLF*I *RFW*PVVYFYFPVTVFVLFFSFFLPFDPIHVS THYAQIKLHLQTP*YDLWRMYTV*THQ*IL*LPP R

Sequence APLP2.fAug05

AATATGAAGTCAGTTCCGGTTGGTGTAAAACCCCCGGGGCGGCGGCGAACTGGCTTTAGATGCTTCTGGGTCGCGGTGTGCTAAGCGAGGAGTCCGAGTG TGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGCCACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCT GGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCTCTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCA ATGTTTTGTGGGAAGTTAAATATGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGCATGCTGCTCCCATGTGGGGTAGACCAGTTCCATGGCAC TGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAAGAGGAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAA GACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGATCTGGAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGG AGGAAGTGGTGGAGGACCGAGATTACTACTATGACACCTTCAAAGGAGATGACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTC AGACAAGGAAATTACTCATGATGTCAAAGTTCCTCCAACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCAT GCTCGCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGA ACCTCCCCAAAGCAGAGAGGCAGACTCTGATTCAGCACTTCCAAGCCATGGTTAAAGCTTTAGAGAAGGAAGCAGCCAGTGAGAAGCAGCAGCTGGTGGA GACCCACCTGGCCCGAGTGGAAGCTATGCTGAATGACCGCCGTCGGATGGCTCTGGAGAACTACCTGGCTGCCTTGCAGTCTGACCCGCCACGGCCTCAT CGCATTCTCCAGGCCTTACGGCGTTATGTCCGTGCTGAGAACAAAGATCGCTTACATACCATCCGTCATTACCAGCATGTGTTGGCTGTTGACCCAGAAA AGGCGGCCCAGATGAAATCCCAGGTGATGACACATCTCCACGTGATTGAAGAAAGGAGGAACCAAAGCCTCTCTCTGCTCTACAAAGTACCTTATGTAGC CCAAGAAATTCAAGAGGAAATTGATGAGCTCCTTCAGGAGCAGCGTGCAGATATGGACCAGTTCACTGCCTCAATCTCAGAGACCCCTGTGGACGTCCGG GTGAGCTCTGAGGAGAGTGAGGAGATCCCACCGTTCCACCCCTTCCACCCCTTCCCAGCCCTACCTGAGAACGAAGGATCTGGAGTGGGAGAGCAGGATG GGGGACTGATCGGTGCCGAAGAGAAAGTGATTAACAGTAAGAATAAAGTGGATGAAAACATGGTCATTGACGAGACTCTGGATGTTAAGGAAATGATTTT CAATGCCGAGAGAGTTGGAGGCCTCGAGGAAGAGCGGGAATCCGTGGGCCCACTGCGGGAGGACTTCAGTCTGAGTAGCAGTGCTCTCATTGGCCTGCTG GTCATCGCAGTGGCCATTGCCACGGTCATCGTCATCAGCCTGGTGATGCTGAGGAAGAGGCAGTATGGCACCATCAGCCACGGGATCGTGGAGGTTGATC CAATGCTCACCCCAGAAGAGCGTCACCTGAACAAGATGCAGAACCATGGCTATGAGAACCCCACCTACAAATACCTGGAGCAGATGCAGATTTAGGTGGC AGGGAGCGCGGCAGCCCTGGCGGAGGGATGCAGGTGGGCCGGAAGATCCCACGATTCCGATCGACTGCCAAGCAGCAGCCGCTGCCAGGGGCTGCGTCTG ACATCCTGACCTCCTGGACTGTAGGACTATATAAAGTACTACTGTAGAACTGCAATTTCCATTCTTTTAAATGGGTGAAAAATGGTAATATAACAATATA TGATATATAAACCTTAAATGAAAAAAATGATCTATTGCAGATATTTGATGTAGTTTTCTTTTTTAAATTAATCAGAAACCCCACTTCCATTGTATTGTCT GACACATGCTCTCAATATATAATAAATGGGAAATGTCGATTTTCAATAATAGACTTATATGCAGGCTGTCGTTCCGGTTATGTTGTGTAAGTCAACTCTT CAGCCTCATTCACTGTCCTGGCTTTTATTTAAAGAAAAAAAAGGCAGTATTCCCTTTTTAAATGAGCTTTCAGGAAGTTGCTGAGAAATGGGGTGGAATA GGGAACTGTAATGGCCACTGAAGCACGTGAGAGACCCTCGCAAAATGATGTGAAAGGACCAGTTTCTTGAAGTCCAGTGTTTCCACGGCTGGATACCTGT GTGTCTCCATAAAAGTCCTGTCACCAAGGACGTTAAAGGCATTTTATTCCAGCGTCTTCTAGAGAGCTTAGTGTATACAGATGAGGGTGTCCGCTGCTGC TTTCCTTCGGAATCCAGTGCTTCCACAGAGATTAGCCTGTAGCTTATATTTGACATTCTTCACTGTCTGTTGTTTACCTACCGTAGCTTTTTACCGTTCA CTTCCCCTTCCAACTATGTCCAGATGTGCAGGCTCCTCCTCTCTGGACTTTCTCCAAAGGCACTGACCCTCGGCCTCTACTTTGTCCCCTCACCTCCACC CCCTCCTGTCACCGGCCTTGTGACATTCACTCAGAGAAGACCACACCAAGGAGGCGGCCGCTGGCCCAGGAGAGAACACGGGGAGGTTTGTTTGTGTGAA AGGAAAGTAGTCCAGGCTGTCCCTGAAACTGAGTCTGTGGACACTGTGGAAAGCTTTGAACAATTGTGTTTTCGTCACAGGAGTCTTTGTAATGCTTGTA CAGTTGATGTCGATGCTCACTGCTTCTGCTTTTTCTTTCTTTTTATTTTAAATCTGAAGGTTCTGGTAACCTGTGGTGTATTTTTATTTTCCTGTGACTG TTTTTGTTTTGTTTTTTTCCTTTTTCCTCCCCTTTGACCCTATTCATGTCTCTACCCACTATGCACAGATTAAACTTCACCTACAAACTCCTTAATATGA TCTGTGGAGAATGTACACAGTTTAAACACATCAATAAATACTTTAACTTCCACCGAGACT

APLP2-F1 (forward primer)
APLP2-R1 (reverse primer)
Alternative donor and acceptor

Frame 0

NMKSVPVGVKPPGRRRTGFRCFWVAVC*ARSPS V*A*EPRARATRRGMAATGTAAAAATGRLLLLLL VGLTAPALALAGYIEALAANAGTGFAVAEPQIA MFCGKLNMHV*LRE*PYIATACCSHVG*TSSMA LNMCAALRQRLLDLCQKKRKRKMKRKRKRKMKRK TMMFIKVNFLLKQIWKTSQKQLWMRMMRMRKKG RKWWRTEITTMTPSKEMTTMRRILLNPAATAPC QTRKLLMMSKFLQLLCQPMMLMCISRPLQMIMSM LASRRLRSSWRFGTATEWTG*RRNGKRQSFKLR TSPKQRGRL*FSTSKPWLKL*RRKQPVRSSSWW RPTWPEWKLC*MTAVGWLWRTTWLPCSLTRHGLI AFSRPYGVMSVLRTKIAYIPSVITSMCWLLTQK RRPR*NPR**HIST*LKKGGTKASLCSTKYLM* PKKFKRKLMSSFRSSVQIWTSSLPQSQRPLWTSG *ALRRVRRSHRSTPSTPSQPYLRTKDLEWESRM GD*SVPKRK*LTVRIKWMKTWSLTRLWMLRK*F SMPRELEASRKSGNPWAHCGRTSV*VAVLSLACW SSQWPLPRSSSSAW*C*GRGSMAPSATGSWRLI QCSPQKSVT*TRCRTMAMRTPPTNTWSRCRFRW QGARQPWRRDAGGPEDPTIPIDCQAAAAARGCV* HPDLLDCRTI*STTVELQFPFF*MGEKW*YNNI *YINLK*KK*SIADI*CSFLF*INQKPHFHCIV *HMLSIYNKWEMSIFNNRLICRLSFRLCCVSQLF SLIHCPGFYLKKKKAVFPF*MSFQEVAEKWGGI GNCNGH*ST*ETLAK*CERTSFLKSSVSTAGYL CVSIKVLSPRTLKAFYSSVF*RA*CIQMRVSAAA FLRNPVLPQRLACSLYLTFFTVCCLPTVAFYRS LPLPTMSRCAGSSSLDFLQRH*PSASTLSPHLH PLLSPAL*HSLREDHTKEAAAGPGENTGRFVCVK GK*SRLSLKLSLWTLWKALNNCVFVTGVFVMLV QLMSMLTASAFSFFLF*I*RFW*PVVYFYFPVT VFVLFFSFFLPFDPIHVSTHYAQIKLHLQTP*YD LWRMYTV*THQ*IL*LPPR

Frame 1

I*SQFRLV*NPRGGGELALDASGSRCAKRGVRV CELESRALERPGEGWRPPGPRPPQPRAGSCFCC WWGSRRLPWRWPATSRLLQPMPEQDLLLLSLKSQ CFVGS*ICMSDSGNDLI*LRHAAPMWGRPVPWH *ICVLPSDKDYWICVKRRGRGR*RGRGRGR*RG RL*CL*K*ISY*SRSGRLHRSSCG*G**G*GRRG GSGGGPRLLL*HLQRR*LQ*GESY*TRQRRHHV RQGNYS*CQSSSNSSANQ*C*CVFRDLCR***A CSLPEG*GAAGDSAPQPNGQGKEGMGRGRASS*E PPQSREADSDSALPSHG*SFREGSSQ*EAAAGG DPPGPSGSYAE*PPSDGSGELPGCLAV*PATAS SHSPGLTALCPC*EQRSLTYHPSLPACVGC*PRK GGPDEIPGDDTSPRD*RKEEPKPLSALQSTLCS PRNSRGN**APSGAACRYGPVHCLNLRDPCGRP GEL*GE*GDPTVPPLPPLPSPT*ERRIWSGRAGW GTDRCRRESD*Q*E*SG*KHGH*RDSGC*GNDF QCRESWRPRGRAGIRGPTAGGLQSE*QCSHWPA GHRSGHCHGHRHQPGDAEEEAVWHHQPRDRGG*S NAHPRRASPEQDAEPWL*EPHLQIPGADADLGG RERGSPGGGMQVGRKIPRFRSTAKQQPLPGAAS DILTSWTVGLYKVLL*NCNFHSFKWVKNGNITIY DI*TLNEKNDLLQIFDVVFFFKLIRNPTSIVLS DTCSQYIINGKCRFSIIDLYAGCRSGYVV*VNS SASFTVLAFI*RKKRQYSLFK*AFRKLLRNGVE* GTVMATEARERPSQNDVKGPVS*SPVFPRLDTC VSP*KSCHQGR*RHFIPASSRELSVYR*GCPLL LSFGIQCFHRD*PVAYI*HSSLSVVYLP*LFTVH FPFQLCPDVQAPPLWTFSKGTDPRPLLCPLTST PSCHRPCDIHSEKTTPRRRPLAQERTRGGLFV* KESSPGCP*N*VCGHCGKL*TIVFSSQESL*CLY S*CRCSLLLLFLSFYFKSEGSGNLWCIFIFL*L FLFCFFPFSSPLTLFMSLPTMHRLNFTYKLLNM ICGECTQFKHINKYFNFHRD

Frame 2

YEVSSGWCKTPGAAANWL*MLLGRGVLSEESEC VSLRAAR*SDPARDGGHRDRGRRSHGQAPASAA GGAHGACLGAGRLHRGSCSQCRNRICCC*ASNR NVLWEVKYACLTQGMTLYSYGMLLPCGVDQFHGT EYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEE DYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEG EEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMS DKEITHDVKVPPTPLPTNDVDVYFETSADDNEH ARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVE THLARVEAMLNDRRRMALENYLAALQSDPPRPH RILQALRRYVRAENKDRLHTIRHYQHVLAVDPE KAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVA QEIQEEIDELLQEQRADMDQFTASISETPVDVR VSSEESEEIPPFHPFHPFPALPENEGSGVGEQD GGLIGAEEKVINSKNKVDENMVIDETLDVKEMIF NAERVGGLEEERESVGPLREDFSLSSSALIGLL VIAVAIATVIVISLVMLRKRQYGTISHGIVEVD PMLTPEERHLNKMQNHGYENPTYKYLEQMQI*VA GSAAALAEGCRWAGRSHDSDRLPSSSRCQGLRL TS*PPGL*DYIKYYCRTAISILLNG*KMVI*QY MIYKP*MKKMIYCRYLM*FSFLN*SETPLPLYCL THALNI**MGNVDFQ**TYMQAVVPVMLCKSTL QPHSLSWLLFKEKKGSIPFLNELSGSC*EMGWN REL*WPLKHVRDPRKMM*KDQFLEVQCFHGWIPV CLHKSPVTKDVKGILFQRLLESLVYTDEGVRCC FPSESSASTEISL*LIFDILHCLLFTYRSFLPF TSPSNYVQMCRLLLSGLSPKALTLGLYFVPSPPP PPVTGLVTFTQRRPHQGGGRWPRREHGEVCLCE RKVVQAVPETESVDTVESFEQLCFRHRSLCNAC TVDVDAHCFCFFFLFILNLKVLVTCGVFLFSCDC FCFVFFLFPPL*PYSCLYPLCTD*TSPTNSLI* SVENVHSLNTSINTLTSTET

Sequence APLP2.eAug05

AATATGAAGTCAGTTCCGGTTGGTGTAAAACCCCCGGGGCGGCGGCGAACTGGCTTTAGATGCTTCTGGGTCGCGGTGTGCTAAGCGAGGAGTCCGAGTG TGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGCCACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCT GGCTCTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCAATGTTTTGTGGGAAGTTAAATATGCATGTGAACATTCAGACTGGG AAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAGTTCTTCAGTACTGTCAGGAGATGTATCCAGAGCTACAGATCACAA ATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAAAAAGCAATGCAAGAGTCGCTTTGTTACACCTTTCAAGTGTCTCGT GGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCACAAAGAGCGGATGGAGGTGTGTGAGAATCACCAGCACTGGCACACG GTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGCATGCTGCTCCCATGTGGGGTAGACCAGTTCCATGGCACTGAATATGTGT GCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAAGAGGAAGAGGAAGATGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGT TTATAAAAGTGAATTTCCTACTGAAGCAGATCTGGAAGACTTCACAGAAGCAGCTGTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTG GAGGACCGAGATTACTACTATGACACCTTCAAAGGAGATGACTACAATGAGGAGAATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAA TTACTCATGATGTCAAAGTTCCTCCAACTCCTCTGCCAACCAATGATGTTGATGTGTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCA GAAGGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAGAAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAA GCAGAGAGGCAGACTCTGATTCAGCACTTCCAAGCCATGGTTAAAGCTTTAGAGAAGGAAGCAGCCAGTGAGAAGCAGCAGCTGGTGGAGACCCACCTGG CCCGAGTGGAAGCTATGCTGAATGACCGCCGTCGGATGGCTCTGGAGAACTACCTGGCTGCCTTGCAGTCTGACCCGCCACGGCCTCATCGCATTCTCCA GGCCTTACGGCGTTATGTCCGTGCTGAGAACAAAGATCGCTTACATACCATCCGTCATTACCAGCATGTGTTGGCTGTTGACCCAGAAAAGGCGGCCCAG ATGAAATCCCAGGTGATGACACATCTCCACGTGATTGAAGAAAGGAGGAACCAAAGCCTCTCTCTGCTCTACAAAGTACCTTATGTAGCCCAAGAAATTC AAGAGGAAATTGATGAGCTCCTTCAGGAGCAGCGTGCAGATATGGACCAGTTCACTGCCTCAATCTCAGAGACCCCTGTGGACGTCCGGGTGAGCTCTGA GGAGAGTGAGGAGATCCCACCGTTCCACCCCTTCCACCCCTTCCCAGCCCTACCTGAGAACGAAGACACTCAGCCGGAGTTGTACCACCCAATGAAAAAA GGATCTGGAGTGGGAGAGCAGGATGGGGGACTGATCGGTGCCGAAGAGAAAGTGATTAACAGTAAGAATAAAGTGGATGAAAACATGGTCATTGACGAGA CTCTGGATGTTAAGGAAATGATTTTCAATGCCGAGAGAGTTGGAGGCCTCGAGGAAGAGCGGGAATCCGTGGGCCCACTGCGGGAGGACTTCAGTCTGAG TAGCAGTGCTCTCATTGGCCTGCTGGTCATCGCAGTGGCCATTGCCACGGTCATCGTCATCAGCCTGGTGATGCTGAGGAAGAGGCAGTATGGCACCATC AGCCACGGGATCGTGGAGGTTGATCCAATGCTCACCCCAGAAGAGCGTCACCTGAACAAGATGCAGAACCATGGCTATGAGAACCCCACCTACAAATACC TGGAGCAGATGCAGATTTAGGTGGCAGGGAGCGCGGCAGCCCTGGCGGAGGGATGCAGATGTGCAGGCTCCTCCTCTCTGGACTTTCTCCAAAGGCACTG ACCCTCGGCCTCTACTTTGTCCCCTCACCTCCACCCCCTCCTGTCACCGGCCTTGTGACATTCACTCAGAGAAGACCACACCAAGGAGGCGGCCGCTGGC CCAGGAGAGAACACGGGGAGGTTTGTTTGTGTGAAAGGAAAGTAGTCCAGGCTGTCCCTGAAACTGAGTCTGTGGACACTGTGGAAAGCTTTGAACAATT GTGTTTTCGTCACAGGAGTCTTTGTAATGCTTGTACAGTTGATGTCGATGCTCACTGCTTCTGCTTTTTCTTTCTTTTTATTTTAAATCTGAAGGTTCTG GTAACCTGTGGTGTATTTTTATTTTCCTGTGACTGTTTTTGTTTTGTTTTTTTCCTTTTTCCTCCCCTTTGACCCTATTCATGTCTCTACCCACTATGCA CAGATTAAACTTCACCTACAAACTCCTTAATATGATCTGTGGAGAATGTACACAGTTTAAACACATCAATAAATACTTTAACTTCCACCGAGACT

APLP2-F1 (forward primer)
APLP2-R1 (reverse primer)
Alternative donor and acceptor

Frame 0

NMKSVPVGVKPPGRRRTGFRCFWVAVC*ARSPS V*A*EPRARATRRGMAATGTAAAAATGRLLLLLL ALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTG KWEPDPTGTKSCFETKEEVLQYCQEMYPELQIT NVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLV GEFVSDVLLVPEKCQFFHKERMEVCENHQHWHT VVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYV CCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDV YKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVV EDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE ITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQ KAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPK AERQTLIQHFQAMVKALEKEAASEKQQLVETHL ARVEAMLNDRRRMALENYLAALQSDPPRPHRILQ ALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQ MKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEI QEEIDELLQEQRADMDQFTASISETPVDVRVSSE ESEEIPPFHPFHPFPALPENEDTQPELYHPMKK GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDE TLDVKEMIFNAERVGGLEEERESVGPLREDFSLS SSALIGLLVIAVAIATVIVISLVMLRKRQYGTI SHGIVEVDPMLTPEERHLNKMQNHGYENPTYKY LEQMQI*VAGSAAALAEGCRCAGSSSLDFLQRH* PSASTLSPHLHPLLSPAL*HSLREDHTKEAAAG PGENTGRFVCVKGK*SRLSLKLSLWTLWKALNN CVFVTGVFVMLVQLMSMLTASAFSFFLF*I*RFW *PVVYFYFPVTVFVLFFSFFLPFDPIHVSTHYA QIKLHLQTP*YDLWRMYTV*THQ*IL*LPPR

Frame 1

I*SQFRLV*NPRGGGELALDASGSRCAKRGVRV CELESRALERPGEGWRPPGPRPPQPRAGSCFCC WLLQPMPEQDLLLLSLKSQCFVGS*ICM*TFRLG NGNLIQQAPRAALKQKKKFFSTVRRCIQSYRSQ M*WRQTSGLVLTTGAGGTKSNARVALLHLSSVS WVNL*VMSC*FQKSASFSTKSGWRCVRITSTGTR *SKRHV*LRE*PYIATACCSHVG*TSSMALNMC AALRQRLLDLCQKKRKRKMKRKRKRKMKRKTMM FIKVNFLLKQIWKTSQKQLWMRMMRMRKKGRKWW RTEITTMTPSKEMTTMRRILLNPAATAPCQTRK LLMMSKFLQLLCQPMMLMCISRPLQMIMSMLAS RRLRSSWRFGTATEWTG*RRNGKRQSFKLRTSPK QRGRL*FSTSKPWLKL*RRKQPVRSSSWWRPTW PEWKLC*MTAVGWLWRTTWLPCSLTRHGLIAFS RPYGVMSVLRTKIAYIPSVITSMCWLLTQKRRPR *NPR**HIST*LKKGGTKASLCSTKYLM*PKKF KRKLMSSFRSSVQIWTSSLPQSQRPLWTSG*AL RRVRRSHRSTPSTPSQPYLRTKTLSRSCTTQ*KK DLEWESRMGD*SVPKRK*LTVRIKWMKTWSLTR LWMLRK*FSMPRELEASRKSGNPWAHCGRTSV* VAVLSLACWSSQWPLPRSSSSAW*C*GRGSMAPS ATGSWRLIQCSPQKSVT*TRCRTMAMRTPPTNT WSRCRFRWQGARQPWRRDADVQAPPLWTFSKGT DPRPLLCPLTSTPSCHRPCDIHSEKTTPRRRPLA QERTRGGLFV*KESSPGCP*N*VCGHCGKL*TI VFSSQESL*CLYS*CRCSLLLLFLSFYFKSEGS GNLWCIFIFL*LFLFCFFPFSSPLTLFMSLPTMH RLNFTYKLLNMICGECTQFKHINKYFNFHRD

Frame 2

YEVSSGWCKTPGAAANWL*MLLGRGVLSEESEC VSLRAAR*SDPARDGGHRDRGRRSHGQAPASAA GSCSQCRNRICCC*ASNRNVLWEVKYACEHSDW EMGT*SNRHQELL*NKRRSSSVLSGDVSRATDHK CDGGKPAG*Y*QLVPEGQKAMQESLCYTFQVSR G*ICK*CPASSRKVPVFPQRADGGV*ESPALAH GSQRGMSDSGNDLI*LRHAAPMWGRPVPWH*ICV LPSDKDYWICVKRRGRGR*RGRGRGR*RGRL*C L*K*ISY*SRSGRLHRSSCG*G**G*GRRGGSG GGPRLLL*HLQRR*LQ*GESY*TRQRRHHVRQGN YS*CQSSSNSSANQ*C*CVFRDLCR***ACSLP EG*GAAGDSAPQPNGQGKEGMGRGRASS*EPPQ SREADSDSALPSHG*SFREGSSQ*EAAAGGDPPG PSGSYAE*PPSDGSGELPGCLAV*PATASSHSP GLTALCPC*EQRSLTYHPSLPACVGC*PRKGGP DEIPGDDTSPRD*RKEEPKPLSALQSTLCSPRNS RGN**APSGAACRYGPVHCLNLRDPCGRPGEL* GE*GDPTVPPLPPLPSPT*ERRHSAGVVPPNEK RIWSGRAGWGTDRCRRESD*Q*E*SG*KHGH*RD SGC*GNDFQCRESWRPRGRAGIRGPTAGGLQSE *QCSHWPAGHRSGHCHGHRHQPGDAEEEAVWHH QPRDRGG*SNAHPRRASPEQDAEPWL*EPHLQIP GADADLGGRERGSPGGGMQMCRLLLSGLSPKAL TLGLYFVPSPPPPPVTGLVTFTQRRPHQGGGRW PRREHGEVCLCERKVVQAVPETESVDTVESFEQL CFRHRSLCNACTVDVDAHCFCFFFLFILNLKVL VTCGVFLFSCDCFCFVFFLFPPL*PYSCLYPLC TD*TSPTNSLI*SVENVHSLNTSINTLTSTET

Sequence APLP2.dAug05

AATATGAAGTCAGTTCCGGTTGGTGTAAAACCCCCGGGGCGGCGGCGAACTGGCTTTAGATGCTTCTGGGTCGCGGTGTGCTAAGCGAGGAGTCCGAGTG TGTGAGCTTGAGAGCCGCGCGCTAGAGCGACCCGGCGAGGGATGGCGGCCACCGGGACCGCGGCCGCCGCAGCCACGGGCAGGCTCCTGCTTCTGCTGCT GGTGGGGCTCACGGCGCCTGCCTTGGCGCTGGCCGGCTACATCGAGGCTCTTGCAGCCAATGCCGGAACAGGATTTGCTGTTGCTGAGCCTCAAATCGCA ATGTTTTGTGGGAAGTTAAATATGCATGTGAACATTCAGACTGGGAAATGGGAACCTGATCCAACAGGCACCAAGAGCTGCTTTGAAACAAAAGAAGAAG TTCTTCAGTACTGTCAGGAGATGTATCCAGAGCTACAGATCACAAATGTGATGGAGGCAAACCAGCGGGTTAGTATTGACAACTGGTGCCGGAGGGACAA AAAGCAATGCAAGAGTCGCTTTGTTACACCTTTCAAGTGTCTCGTGGGTGAATTTGTAAGTGATGTCCTGCTAGTTCCAGAAAAGTGCCAGTTTTTCCAC AAAGAGCGGATGGAGGTGTGTGAGAATCACCAGCACTGGCACACGGTAGTCAAAGAGGCATGTCTGACTCAGGGAATGACCTTATATAGCTACGGCATGC TGCTCCCATGTGGGGTAGACCAGTTCCATGGCACTGAATATGTGTGCTGCCCTCAGACAAAGATTATTGGATCTGTGTCAAAAGAAGAGGAAGAGGAAGA TGAAGAGGAAGAGGAAGAGGAAGATGAAGAGGAAGACTATGATGTTTATAAAAGTGAATTTCCTACTGAAGCAGATCTGGAAGACTTCACAGAAGCAGCT GTGGATGAGGATGATGAGGATGAGGAAGAAGGGGAGGAAGTGGTGGAGGACCGAGATTACTACTATGACACCTTCAAAGGAGATGACTACAATGAGGAGA ATCCTACTGAACCCGGCAGCGACGGCACCATGTCAGACAAGGAAATTACTCATGATGTCAAAGTTCCTCCAACTCCTCTGCCAACCAATGATGTTGATGT GTATTTCGAGACCTCTGCAGATGATAATGAGCATGCTCGCTTCCAGAAGGCTAAGGAGCAGCTGGAGATTCGGCACCGCAACCGAATGGACAGGGTAAAG AAGGAATGGGAAGAGGCAGAGCTTCAAGCTAAGAACCTCCCCAAAGCAGAGAGGCAGACTCTGATTCAGCACTTCCAAGCCATGGTTAAAGCTTTAGAGA AGGAAGCAGCCAGTGAGAAGCAGCAGCTGGTGGAGACCCACCTGGCCCGAGTGGAAGCTATGCTGAATGACCGCCGTCGGATGGCTCTGGAGAACTACCT GGCTGCCTTGCAGTCTGACCCGCCACGGCCTCATCGCATTCTCCAGGCCTTACGGCGTTATGTCCGTGCTGAGAACAAAGATCGCTTACATACCATCCGT CATTACCAGCATGTGTTGGCTGTTGACCCAGAAAAGGCGGCCCAGATGAAATCCCAGGTGATGACACATCTCCACGTGATTGAAGAAAGGAGGAACCAAA GCCTCTCTCTGCTCTACAAAGTACCTTATGTAGCCCAAGAAATTCAAGAGGAAATTGATGAGCTCCTTCAGGAGCAGCGTGCAGATATGGACCAGTTCAC TGCCTCAATCTCAGAGACCCCTGTGGACGTCCGGGTGAGCTCTGAGGAGAGTGAGGAGATCCCACCGTTCCACCCCTTCCACCCCTTCCCAGCCCTACCT GAGAACGAAGGATCTGGAGTGGGAGAGCAGGATGGGGGACTGATCGGTGCCGAAGAGAAAGTGATTAACAGTAAGAATAAAGTGGATGAAAACATGGTCA TTGACGAGACTCTGGATGTTAAGGAAATGATTTTCAATGCCGAGAGAGTTGGAGGCCTCGAGGAAGAGCGGGAATCCGTGGGCCCACTGCGGGAGGACTT CAGTCTGAGTAGCAGTGCTCTCATTGGCCTGCTGGTCATCGCAGTGGCCATTGCCACGGTCATCGTCATCAGCCTGGTGATGCTGAGGAAGAGGCAGTAT GGCACCATCAGCCACGGGATCGTGGAGGTTGATCCAATGCTCACCCCAGAAGAGCGTCACCTGAACAAGATGCAGAACCATGGCTATGAGAACCCCACCT ACAAATACCTGGAGCAGATGCAGATTTAGGTGGCAGGGAGCGCGGCAGCCCTGGCGGAGGGATGCAGGTGGGCCGGAAGATCCCACGATTCCGATCGACT GCCAAGCAGCAGCCGCTGCCAGGGGCTGCGTCTGACATCCTGACCTCCTGGACTGTAGGACTATATAAAGTACTACTGTAGAACTGCAATTTCCATTCTT TTAAATGGGTGAAAAATGGTAATATAACAATATATGATATATAAACCTTAAATGAAAAAAATGATCTATTGCAGATATTTGATGTAGTTTTCTTTTTTAA ATTAATCAGAAACCCCACTTCCATTGTATTGTCTGACACATGCTCTCAATATATAATAAATGGGAAATGTCGATTTTCAATAATAGACTTATATGCAGGC TGTCGTTCCGGTTATGTTGTGTAAGTCAACTCTTCAGCCTCATTCACTGTCCTGGCTTTTATTTAAAGAAAAAAAAGGCAGTATTCCCTTTTTAAATGAG CTTTCAGGAAGTTGCTGAGAAATGGGGTGGAATAGGGAACTGTAATGGCCACTGAAGCACGTGAGAGACCCTCGCAAAATGATGTGAAAGGACCAGTTTC TTGAAGTCCAGTGTTTCCACGGCTGGATACCTGTGTGTCTCCATAAAAGTCCTGTCACCAAGGACGTTAAAGGCATTTTATTCCAGCGTCTTCTAGAGAG CTTAGTGTATACAGATGAGGGTGTCCGCTGCTGCTTTCCTTCGGAATCCAGTGCTTCCACAGAGATTAGCCTGTAGCTTATATTTGACATTCTTCACTGT CTGTTGTTTACCTACCGTAGCTTTTTACCGTTCACTTCCCCTTCCAACTATGTCCAGATGTGCAGGCTCCTCCTCTCTGGACTTTCTCCAAAGGCACTGA CCCTCGGCCTCTACTTTGTCCCCTCACCTCCACCCCCTCCTGTCACCGGCCTTGTGACATTCACTCAGAGAAGACCACACCAAGGAGGCGGCCGCTGGCC CAGGAGAGAACACGGGGAGGTTTGTTTGTGTGAAAGGAAAGTAGTCCAGGCTGTCCCTGAAACTGAGTCTGTGGACACTGTGGAAAGCTTTGAACAATTG TGTTTTCGTCACAGGAGTCTTTGTAATGCTTGTACAGTTGATGTCGATGCTCACTGCTTCTGCTTTTTCTTTCTTTTTATTTTAAATCTGAAGGTTCTGG TAACCTGTGGTGTATTTTTATTTTCCTGTGACTGTTTTTGTTTTGTTTTTTTCCTTTTTCCTCCCCTTTGACCCTATTCATGTCTCTACCCACTATGCAC AGATTAAACTTCACCTACAAACTCCTTAATATGATCTGTGGAGAATGTACACAGTTTAAACACATCAATAAATACTTTAACTTCCACCGAGACT

APLP2-F1 (forward primer)
APLP2-R1 (reverse primer)
Alternative donor and acceptor

Frame 0

NMKSVPVGVKPPGRRRTGFRCFWVAVC*ARSPS V*A*EPRARATRRGMAATGTAAAAATGRLLLLLL VGLTAPALALAGYIEALAANAGTGFAVAEPQIA MFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEE VLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFH KERMEVCENHQHWHTVVKEACLTQGMTLYSYGM LLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEED EEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAA VDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEE NPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDV YFETSADDNEHARFQKAKEQLEIRHRNRMDRVK KEWEEAELQAKNLPKAERQTLIQHFQAMVKALE KEAASEKQQLVETHLARVEAMLNDRRRMALENYL AALQSDPPRPHRILQALRRYVRAENKDRLHTIR HYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQ SLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFT ASISETPVDVRVSSEESEEIPPFHPFHPFPALP ENEGSGVGEQDGGLIGAEEKVINSKNKVDENMV IDETLDVKEMIFNAERVGGLEEERESVGPLREDF SLSSSALIGLLVIAVAIATVIVISLVMLRKRQY GTISHGIVEVDPMLTPEERHLNKMQNHGYENPT YKYLEQMQI*VAGSAAALAEGCRWAGRSHDSDRL PSSSRCQGLRLTS*PPGL*DYIKYYCRTAISIL LNG*KMVI*QYMIYKP*MKKMIYCRYLM*FSFL N*SETPLPLYCLTHALNI**MGNVDFQ**TYMQA VVPVMLCKSTLQPHSLSWLLFKEKKGSIPFLNE LSGSC*EMGWNREL*WPLKHVRDPRKMM*KDQF LEVQCFHGWIPVCLHKSPVTKDVKGILFQRLLES LVYTDEGVRCCFPSESSASTEISL*LIFDILHC LLFTYRSFLPFTSPSNYVQMCRLLLSGLSPKAL TLGLYFVPSPPPPPVTGLVTFTQRRPHQGGGRWP RREHGEVCLCERKVVQAVPETESVDTVESFEQL CFRHRSLCNACTVDVDAHCFCFFFLFILNLKVL VTCGVFLFSCDCFCFVFFLFPPL*PYSCLYPLCT D*TSPTNSLI*SVENVHSLNTSINTLTSTET

Frame 1

I*SQFRLV*NPRGGGELALDASGSRCAKRGVRV CELESRALERPGEGWRPPGPRPPQPRAGSCFCC WWGSRRLPWRWPATSRLLQPMPEQDLLLLSLKSQ CFVGS*ICM*TFRLGNGNLIQQAPRAALKQKKK FFSTVRRCIQSYRSQM*WRQTSGLVLTTGAGGT KSNARVALLHLSSVSWVNL*VMSC*FQKSASFST KSGWRCVRITSTGTR*SKRHV*LRE*PYIATAC CSHVG*TSSMALNMCAALRQRLLDLCQKKRKRK MKRKRKRKMKRKTMMFIKVNFLLKQIWKTSQKQL WMRMMRMRKKGRKWWRTEITTMTPSKEMTTMRR ILLNPAATAPCQTRKLLMMSKFLQLLCQPMMLM CISRPLQMIMSMLASRRLRSSWRFGTATEWTG*R RNGKRQSFKLRTSPKQRGRL*FSTSKPWLKL*R RKQPVRSSSWWRPTWPEWKLC*MTAVGWLWRTT WLPCSLTRHGLIAFSRPYGVMSVLRTKIAYIPSV ITSMCWLLTQKRRPR*NPR**HIST*LKKGGTK ASLCSTKYLM*PKKFKRKLMSSFRSSVQIWTSS LPQSQRPLWTSG*ALRRVRRSHRSTPSTPSQPYL RTKDLEWESRMGD*SVPKRK*LTVRIKWMKTWS LTRLWMLRK*FSMPRELEASRKSGNPWAHCGRT SV*VAVLSLACWSSQWPLPRSSSSAW*C*GRGSM APSATGSWRLIQCSPQKSVT*TRCRTMAMRTPP TNTWSRCRFRWQGARQPWRRDAGGPEDPTIPID CQAAAAARGCV*HPDLLDCRTI*STTVELQFPFF *MGEKW*YNNI*YINLK*KK*SIADI*CSFLF* INQKPHFHCIV*HMLSIYNKWEMSIFNNRLICR LSFRLCCVSQLFSLIHCPGFYLKKKKAVFPF*MS FQEVAEKWGGIGNCNGH*ST*ETLAK*CERTSF LKSSVSTAGYLCVSIKVLSPRTLKAFYSSVF*R A*CIQMRVSAAAFLRNPVLPQRLACSLYLTFFTV CCLPTVAFYRSLPLPTMSRCAGSSSLDFLQRH* PSASTLSPHLHPLLSPAL*HSLREDHTKEAAAG PGENTGRFVCVKGK*SRLSLKLSLWTLWKALNNC VFVTGVFVMLVQLMSMLTASAFSFFLF*I*RFW *PVVYFYFPVTVFVLFFSFFLPFDPIHVSTHYA QIKLHLQTP*YDLWRMYTV*THQ*IL*LPPR

Frame 2

YEVSSGWCKTPGAAANWL*MLLGRGVLSEESEC VSLRAAR*SDPARDGGHRDRGRRSHGQAPASAA GGAHGACLGAGRLHRGSCSQCRNRICCC*ASNR NVLWEVKYACEHSDWEMGT*SNRHQELL*NKRRS SSVLSGDVSRATDHKCDGGKPAG*Y*QLVPEGQ KAMQESLCYTFQVSRG*ICK*CPASSRKVPVFP QRADGGV*ESPALAHGSQRGMSDSGNDLI*LRHA APMWGRPVPWH*ICVLPSDKDYWICVKRRGRGR *RGRGRGR*RGRL*CL*K*ISY*SRSGRLHRSS CG*G**G*GRRGGSGGGPRLLL*HLQRR*LQ*GE SY*TRQRRHHVRQGNYS*CQSSSNSSANQ*C*C VFRDLCR***ACSLPEG*GAAGDSAPQPNGQGK EGMGRGRASS*EPPQSREADSDSALPSHG*SFRE GSSQ*EAAAGGDPPGPSGSYAE*PPSDGSGELP GCLAV*PATASSHSPGLTALCPC*EQRSLTYHP SLPACVGC*PRKGGPDEIPGDDTSPRD*RKEEPK PLSALQSTLCSPRNSRGN**APSGAACRYGPVH CLNLRDPCGRPGEL*GE*GDPTVPPLPPLPSPT *ERRIWSGRAGWGTDRCRRESD*Q*E*SG*KHGH *RDSGC*GNDFQCRESWRPRGRAGIRGPTAGGL QSE*QCSHWPAGHRSGHCHGHRHQPGDAEEEAV WHHQPRDRGG*SNAHPRRASPEQDAEPWL*EPHL QIPGADADLGGRERGSPGGGMQVGRKIPRFRST AKQQPLPGAASDILTSWTVGLYKVLL*NCNFHS FKWVKNGNITIYDI*TLNEKNDLLQIFDVVFFFK LIRNPTSIVLSDTCSQYIINGKCRFSIIDLYAG CRSGYVV*VNSSASFTVLAFI*RKKRQYSLFK* AFRKLLRNGVE*GTVMATEARERPSQNDVKGPVS *SPVFPRLDTCVSP*KSCHQGR*RHFIPASSRE LSVYR*GCPLLLSFGIQCFHRD*PVAYI*HSSL SVVYLP*LFTVHFPFQLCPDVQAPPLWTFSKGTD PRPLLCPLTSTPSCHRPCDIHSEKTTPRRRPLA QERTRGGLFV*KESSPGCP*N*VCGHCGKL*TI VFSSQESL*CLYS*CRCSLLLLFLSFYFKSEGSG NLWCIFIFL*LFLFCFFPFSSPLTLFMSLPTMH RLNFTYKLLNMICGECTQFKHINKYFNFHRD