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Sequences

Sequence APG5L.eAug05

APG5L.u.f.9 (forward primer)
APG5L.u.r.5 (reverse primer)
Single exon skipping

Frame 0

VTSSPGAEGDWTCGALPGLRSVAGCIRWIPEGG SAAGFSSDLRAGAFCGCAGFLESCYRVPAGQCVR RAACPAAPPERGIWASPPVRGAGRRSHSLE*VW LWLK*EFSLYVLL*LLEE*QMTKMCFEMCGLDE FQLVSRYIRMR*LKGKQNHTMHYPIGLLFDLLAS SSALPWNITVHFKSFPEKDLLHCPSKDAIEAHF MSCMKEADALKHKSQVINEMQKKDHKQLWMGLQ NDRFDQFWAINRKLMEYPAEENGFRYIPFRIYQT TTERPFIQKLFRPVAADGQLHTLGDLLKEVCPS AIDPEGNTISNIKTFLSFSVTEVK*AFHIYKQQ VISGRYFHILQRKVFSNRST*YLIYYFVNY*LTK **LDWRNKIQFLNH

Frame 1

*RHLRAPRVTGLVVRCQGSAALPVVFAGYQRAE VQQGSAPTSAPVLFAAARASWSPATASPQDSVS GGQLAPPPHRSAESGRPHQCGEPEGGAIAWSRFG FG*NKNLACMYCFNSWKNDR*QRCASRCVVWTN SNLFHAISG*DN*KGSRTILCIIQLVCYLIFLH QVQLFLGTSQYILRVFQKKTFCTVHLRMQLKLIL CHV*KKLML*NIKVK*SMKCRKKITSNSGWDCK MTDLTSFGPSIGNSWNILQKKMDFVISPLEYIR QRLKDLSFRSCFVLWLQMDSCTH*EISSKKFVLL LLILKVIQSATLKHFFHFLLLK*NKHSTFINNR LFQEDIFISYSEKSFQTEAPNI*YIIL*IID*Q NDDSTGEIKYSF*I

Frame 2

DVISGRRG*LDLWCAARAPQRCRLYSLDTRGRK CSRVQLRPPRRCFLRLRGLPGVLLPRPRRTVCQ AGSLPRRPTGARNLGVPTSAGSRKEEP*LGVGL ALVEIRI*PVCTALTPGRMTDDKDVLRDVWFGRI PTCFTLYQDEITEREAEPYYALSNWFAI*SSCI KFSSSLEHHSTF*EFSRKRPSALSI*GCN*SSF YVMYERS*CFKT*KSSNQ*NAEKRSQATLDGIAK *QI*PVLGHQSETHGISCRRKWISLYPL*NISD ND*KTFHSEAVSSCGCRWTVAHTRRSPQRSLSF CY*S*R*YNQQH*NISFIFCY*SKISIPHL*TTG YFRKIFSYLTAKSLFKQKHLIFNILFCKLLTNK MMTRLAK*NTVFKS

Sequence APG5L.cAug05

GTGACGTCATCTCCGGGCGCCGAGGGTGACTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAA GTGCAGCAGGGTTCAGCTCCGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAG GCGGGCAGCTTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTGG CTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAAT TCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATGCATTATCCAATTGGTTTGCTATTTGATCTTCTTGCATC AAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCCATCTAAGGATGCAATTGAAGCTCATTTT ATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAA ATGACAGATTTGACCAGTTTTGGGCCATCAATCGGAAACTCATGGAATATCCTGCAGAAGAAAATGGATTTCGTTATATCCCCTTTAGAATATATCAGAC AACGACTGAAAGACCTTTCATTCAGAAGCTGTTTCGTCCTGTGGCTGCAGATGGACAGTTGCACACACTAGGAGATCTCCTCAAAGAAGTTTGTCCTTCT GCTATTGATCCTGAAGATGGGGAAAAAAAGAATCAAGTGATGATTCATGGAATTGAGCCAATGTTGGAAACACCTCTGCAGTGGCTGAGTGAACATCTGA GCTACCCGGATAATTTTCTTCATATTAGTATCATCCCACAGCCAACAGATTGAAGGATCAACTATTTGCCTGAACAGAATCATCCTTAAATGGGATTTAT CAGAGCATGTCACCCTTTTGCTTCAATCAGGTTTGGTGGAGGCAACCTGACCAGAAACACTTCGCTGCTGCAAGCCAGACAGGAAAAAGATTCCATGTCA GATAAGGCAACTGGGCTGGTCTTACTTTGCATCACCTCTGCTTTCCTCCACTGCCATCATTAAACCTCAGCTGTGACATGAAAGACTTACCGGACCACTG AAGGTCTTCTGTAAAATATAATGAAGCTGAAACCTTTGGCCTAAGAAGAAAATGGAAGTATGTGCCACTCGATTTGTATTTCTGATTAACAAATAAACAG GGGTATTTCCTAAGGTGACCATGGTTGAACTTTAGCTCATGAAAGTGGAAACATTGGTTTAATTTTCAAGAGAATTAAGAAAGTAAAAGAGAAATTCTGT TATCAATAACTTGCAAGTAATTTTTTGTAAAAGATTGAATTACAGTAAACCCATCTTTCCTTAACGAAAATTTCCTATGTTTACAGTCTGTCTATTGGTA TGCAATCTTGTAACTTTGATAATGAACAGTGAGAGATTTTTAAATAAAGCCTCTAAATATGTTTTGTCATTTAATAACATACAGTTTTGTCACTTTTCAA GTACTTTCTGACTCACATACAGTAGATCACTTTTTACTCTGTGTTACCATTTTGACTGGTCGTCATTGGCATGGGGTGGATATAGGGCATAGGATTACTT GTCTCAGAAGCTGTCATAGAATTTCTTGCTGCCAATTAAAAAACCTGTGTTCTTTACACACTACACGTATAAATATTGTAACTGTTCATCTTTGTTGTTT TATCACTGTAAGCCTGTCAAATCATAGTATCCTAAGCATCTGTAAATGCTAATTTTGCATTTTTGGAAAAACCCATTCCTTCCAAGCTAGTGTTTTTCAT TGGCTCCAGGTCTAATTTTTCACTGTGGTCCCTGGCAGCCAGTCTTTTGAAGTTTAAAGATTACCTGTCTCTTGACTGCAGTACCTTTTCTTTAATTTTT ACCAAAAATATCCAGAGGTTACTGGAGTTCTTATTCAATATAAGGAAAGTTTGCTGCACTTTATTACCAAGCCTCTGGGATTTTACCAGTCAAACATATT TGTGCATTACATTTCATTTCTTGTGAGCTAGCTGGCTGTCCATATTGAATGTTGACCCATTTGAGTACGCTAAAAGGCTTACAGTATCAGACACGATCAT GGTTTTAGATCCCATAATAAAAATGAATGTTTTTCTTATAAAAAATTATACAAATGCTGAAGTGAGATTCTACTATTGTTCATTGCTTCCTTTTCTTTTT CCTTTTGCGATTTTCACTGATTAATAGCACATTTCTTCACAAAATTAGATAAAGTTGGTCAAAGACCAGATATTCTGGAATGGAAATTGTAAAGCTTAAT CAAAAAGAATAGCCAGTACAGCATACAATCTCAGAAACTTAGAAGCAAGTAGAAAATAATTGGTTGATGTAAACGAAAGTGCCATTTTAGTAAAGGCAGG AAAAAAATAGCAATATTTGAGTTATGTAAGGATAAAAAATCCACTGACTTGTATTTTTGCACAAGAGGCTGGTCTGAATATGATTGTTCACATTAAGAGT GTTTATTCGTCGGTTCATTTTGGGGATTTTCCCCCTTGATGTTTTGACAGATTGAAGTGAGCTTTAGTGAGCAAAAGGATCAGAATGCAGGGAACACTAA GCTGTGATGAAGAAAGTGTGGTAAAAAGCCAGAGTAGTTTTATACAGACAAAACCAGTGTCAGGCCTTTGCAGTAGGCTTGAGTGAACTTCTGATCTAGA TTTGAAAGTAAATTTTATGAAGACATTGCCCATTTTTACTTCCTCATTCATTATTGTACCAGCATCATAGCTTTATTACTCTAATCCCAGGTAAGTCAAG CCTACAATGCCCTAGAGGAAGAGTAAAACCAGAAATTCATGCTGGCTTAAATAATCTATTTTTGTTTCTTTTCATTTGAATATTTAAATTTTATGGTTTA TTAAAAAATTAAATAAATGTTGTGTCCGTCTTTATTTAAAACAAGTTACCTGTTGATAAAATCATTAAAATTTCCTTAGTCAC

APG5L.u.f.9 (forward primer)
APG5L.u.r.5 (reverse primer)
Single exon skipping

Frame 0

VTSSPGAEGDWTCGALPGLRSVAGCIRWIPEGG SAAGFSSDLRAGAFCGCAGFLESCYRVPAGQCVR RAACPAAPPERGIWASPPVRGAGRRSHSLE*VW LWLK*EFSLYVLL*LLEE*QMTKMCFEMCGLDE FQLVSRYIRMR*LKGKQNHTMHYPIGLLFDLLAS SSALPWNITVHFKSFPEKDLLHCPSKDAIEAHF MSCMKEADALKHKSQVINEMQKKDHKQLWMGLQ NDRFDQFWAINRKLMEYPAEENGFRYIPFRIYQT TTERPFIQKLFRPVAADGQLHTLGDLLKEVCPS AIDPEDGEKKNQVMIHGIEPMLETPLQWLSEHL SYPDNFLHISIIPQPTD*RINYLPEQNHP*MGFI RACHPFASIRFGGGNLTRNTSLLQARQEKDSMS DKATGLVLLCITSAFLHCHH*TSAVT*KTYRTT EGLL*NIMKLKPLA*EENGSMCHSICISD*QINR GIS*GDHG*TLAHESGNIGLIFKRIKKVKEKFC YQ*LASNFL*KIELQ*THLSLTKISYVYSLSIG MQSCNFDNEQ*EIFK*SL*ICFVI**HTVLSLFK YFLTHIQ*ITFYSVLPF*LVVIGMGWI*GIGLL VSEAVIEFLAAN*KTCVLYTLHV*IL*LFIFVV LSL*ACQIIVS*ASVNANFAFLEKPIPSKLVFFI GSRSNFSLWSLAASLLKFKDYLSLDCSTFSLIF TKNIQRLLEFLFNIRKVCCTLLPSLWDFTSQTY LCITFHFL*ASWLSILNVDPFEYAKRLTVSDTIM VLDPIIKMNVFLIKNYTNAEVRFYYCSLLPFLF PFAIFTD**HISSQN*IKLVKDQIFWNGNCKA* SKRIASTAYNLRNLEASRK*LVDVNESAILVKAG KK*QYLSYVRIKNPLTCIFAQEAGLNMIVHIKS VYSSVHFGDFPP*CFDRLK*ALVSKRIRMQGTL SCDEESVVKSQSSFIQTKPVSGLCSRLE*TSDLD LKVNFMKTLPIFTSSFIIVPAS*LYYSNPR*VK PTMP*RKSKTRNSCWLK*SIFVSFHLNI*ILWF IKKLNKCCVRLYLKQVTC**NH*NFLSH

Frame 1

*RHLRAPRVTGLVVRCQGSAALPVVFAGYQRAE VQQGSAPTSAPVLFAAARASWSPATASPQDSVS GGQLAPPPHRSAESGRPHQCGEPEGGAIAWSRFG FG*NKNLACMYCFNSWKNDR*QRCASRCVVWTN SNLFHAISG*DN*KGSRTILCIIQLVCYLIFLH QVQLFLGTSQYILRVFQKKTFCTVHLRMQLKLIL CHV*KKLML*NIKVK*SMKCRKKITSNSGWDCK MTDLTSFGPSIGNSWNILQKKMDFVISPLEYIR QRLKDLSFRSCFVLWLQMDSCTH*EISSKKFVLL LLILKMGKKRIK**FMELSQCWKHLCSG*VNI* ATRIIFFILVSSHSQQIEGSTICLNRIILKWDL SEHVTLLLQSGLVEAT*PETLRCCKPDRKKIPCQ IRQLGWSYFASPLLSSTAIIKPQL*HERLTGPL KVFCKI**S*NLWPKKKMEVCATRFVFLINK*T GVFPKVTMVEL*LMKVETLV*FSRELRK*KRNSV INNLQVIFCKRLNYSKPIFP*RKFPMFTVCLLV CNLVTLIMNSERFLNKASKYVLSFNNIQFCHFS STF*LTYSRSLFTLCYHFDWSSLAWGGYRA*DYL SQKLS*NFLLPIKKPVFFTHYTYKYCNCSSLLF YHCKPVKS*YPKHL*MLILHFWKNPFLPS*CFS LAPGLIFHCGPWQPVF*SLKITCLLTAVPFL*FL PKISRGYWSSYSI*GKFAALYYQASGILPVKHI CALHFISCELAGCPY*MLTHLSTLKGLQYQTRS WF*IP**K*MFFL*KIIQMLK*DSTIVHCFLFFF LLRFSLINSTFLHKIR*SWSKTRYSGMEIVKLN QKE*PVQHTISET*KQVENNWLM*TKVPF**RQ EKNSNI*VM*G*KIH*LVFLHKRLV*I*LFTLRV FIRRFILGIFPLDVLTD*SEL**AKGSECREH* AVMKKVW*KARVVLYRQNQCQAFAVGLSELLI* I*K*IL*RHCPFLLPHSLLYQHHSFITLIPGKSS LQCPRGRVKPEIHAGLNNLFLFLFI*IFKFYGL LKN*INVVSVFI*NKLPVDKIIKISLV

Frame 2

DVISGRRG*LDLWCAARAPQRCRLYSLDTRGRK CSRVQLRPPRRCFLRLRGLPGVLLPRPRRTVCQ AGSLPRRPTGARNLGVPTSAGSRKEEP*LGVGL ALVEIRI*PVCTALTPGRMTDDKDVLRDVWFGRI PTCFTLYQDEITEREAEPYYALSNWFAI*SSCI KFSSSLEHHSTF*EFSRKRPSALSI*GCN*SSF YVMYERS*CFKT*KSSNQ*NAEKRSQATLDGIAK *QI*PVLGHQSETHGISCRRKWISLYPL*NISD ND*KTFHSEAVSSCGCRWTVAHTRRSPQRSLSF CY*S*RWGKKESSDDSWN*ANVGNTSAVAE*TSE LPG*FSSY*YHPTANRLKDQLFA*TESSLNGIY QSMSPFCFNQVWWRQPDQKHFAAASQTGKRFHV R*GNWAGLTLHHLCFPPLPSLNLSCDMKDLPDH* RSSVKYNEAETFGLRRKWKYVPLDLYF*LTNKQ GYFLR*PWLNFSS*KWKHWFNFQEN*ESKREIL LSITCK*FFVKD*ITVNPSFLNENFLCLQSVYWY AIL*L***TVRDF*IKPLNMFCHLITYSFVTFQ VLSDSHTVDHFLLCVTILTGRHWHGVDIGHRIT CLRSCHRISCCQLKNLCSLHTTRINIVTVHLCCF ITVSLSNHSILSICKC*FCIFGKTHSFQASVFH WLQV*FFTVVPGSQSFEV*RLPVS*LQYLFFNF YQKYPEVTGVLIQYKESLLHFITKPLGFYQSNIF VHYISFLVS*LAVHIEC*PI*VR*KAYSIRHDH GFRSHNKNECFSYKKLYKC*SEILLLFIASFSF SFCDFH*LIAHFFTKLDKVGQRPDILEWKL*SLI KKNSQYSIQSQKLRSK*KIIG*CKRKCHFSKGR KKIAIFELCKDKKSTDLYFCTRGWSEYDCSH*E CLFVGSFWGFSPLMF*QIEVSFSEQKDQNAGNTK L**RKCGKKPE*FYTDKTSVRPLQ*A*VNF*SR FESKFYEDIAHFYFLIHYCTSIIALLL*SQVSQ AYNALEEE*NQKFMLA*IIYFCFFSFEYLNFMVY *KIK*MLCPSLFKTSYLLIKSLKFP*S

Sequence APG5L.dAug05

TGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAATTCCAACTTGTTTCACGCTATATCAG GATGAGATAACTGAAAGGGAAGCAGAACCATACTATTTGCTTTTGCCAAGAGTAAGTTATTTGACGTTGGTAACTGACAAAGTGAAAAAGCACTTTCAGA AGGTTATGAGACAAGAAGACATTAGTGAGATATGGTTTGAATATGAAGGCACACCACTGAAATGGCATTATCCAATTGGTTTGCTATTTGATCTTCTTGC ATCAAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCCATCTAAGGATGCAATTGAAGCTCAT TTTATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGC AAAATGATTTGACCAGTTTTGGGCCATCAATCGGAAACTCATGGAATATCCTGCAGAAGAAAATGGATTTCGTTATATCCCCTTTAGAATATATCAGGTA GGAAATAACATTTTAAAAAACATCCATTTATGAAAGCCTCAGACATCTTAATTGAAGCACTCTAGTGTAGAACTCTTTGTCTGCATAGTAACTAAACGGT ATTTATTAGGGGTTTTCCAAACTGTGTCTTTCAGTGGCAATCAAGTCAGATACCGCACTGAAATATTTGACTCATATGCATTTGGTACTCAT

APG5L.u.f.9 (forward primer)
APG5L.u.r.5 (reverse primer)
Single exon skipping

Frame 0

CMYCFNSWKNDR*QRCASRCVVWTNSNLFHAIS G*DN*KGSRTILFAFAKSKLFDVGN*QSEKALSE GYETRRH**DMV*I*RHTTEMALSNWFAI*SSC IKFSSSLEHHSTF*EFSRKRPSALSI*GCN*SS FYVMYERS*CFKT*KSSNQ*NAEKRSQATLDGIA K*FDQFWAINRKLMEYPAEENGFRYIPFRIYQV GNNILKNIHL*KPQTS*LKHSSVELFVCIVTKR YLLGVFQTVSFSGNQVRYRTEIFDSYAFGTH

Frame 1

VCTALTPGRMTDDKDVLRDVWFGRIPTCFTLYQ DEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQ KVMRQEDISEIWFEYEGTPLKWHYPIGLLFDLLA SSSALPWNITVHFKSFPEKDLLHCPSKDAIEAH FMSCMKEADALKHKSQVINEMQKKDHKQLWMGL QNDLTSFGPSIGNSWNILQKKMDFVISPLEYIR* EITF*KTSIYESLRHLN*STLV*NSLSA**LNG IY*GFSKLCLSVAIKSDTALKYLTHMHLVL

Frame 2

YVLL*LLEE*QMTKMCFEMCGLDEFQLVSRYIR MR*LKGKQNHTICFCQE*VI*RW*LTK*KSTFR RL*DKKTLVRYGLNMKAHH*NGIIQLVCYLIFL HQVQLFLGTSQYILRVFQKKTFCTVHLRMQLKLI LCHV*KKLML*NIKVK*SMKCRKKITSNSGWDC KMI*PVLGHQSETHGISCRRKWISLYPL*NISG RK*HFKKHPFMKASDILIEAL*CRTLCLHSN*TV FIRGFPNCVFQWQSSQIPH*NI*LICIWYS

Sequence APG5L.bAug05

GCCCGCCCGGCCGCGATGGCGGGTGAAGGTGGTTCCTCCGGGCAAGGTGGAGTTGGCGAGACGCCGGCCCGGAGCCCTGGGGCCGGTTGGCGGGTGTGGC CTGCGGGGTCCCTCTTGGGGTACATGTCTGTTGCTTACTAAGTTTGGCTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGA ATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAATTCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAAC CATACTATTTGCTTTTGCCAAGAGTAAGTTATTTGACGTTGGTAACTGACAAAGTGAAAAAGCACTTTCAGAAGGTTATGAGACAAGAAGACATTAGTGA GATATGGTTTGAATATGAAGGCACACCACTGAAATGGCATTATCCAATTGGTTTGCTATTTGATCTTCTTGCATCAAGTTCAGCTCTTCCTTGGAACATC ACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCCATCTAAGGATGCAATTGAAGCTCATTTTATGTCATGTATGAAAGAAGCTGATG CTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAAATGACAGATTTGACCAGTTTTGGGC CATCAATCGGAAACTCATGGAATATCCTGCAGAAGAAAATGGATTTCGTTATATCCCCTTTAGAATATATCAGACAACGACTGAAAGACCTTTCATTCAG AAGCTGTTTCGTCCTGTGGCTGCAGATGGACAGTTGCACACACTAGGAGATCTCCTCAAAGAAGTTTGTCCTTCTGCTATTGATCCTGAAGATGGGGAAA AAAAGAATCAAGTGATGATTCATGGAATTGAGCCAATGTTGGAAACACCTCTGCAGTGGCTGAGTGAACATCTGAGCTACCCGGATAATTTTCTTCATAT TAGTATCATCCCACAGCCAACAGATTGAAGGATCAACTATTTGCCTGAACAGAATCATCCTTAAATGGGATTTATCAGAGCATGTCACCCTTTTGCTTCA ATCAGGTTTGGTGGAGGCAACCTGACCAGAAACACTTCGCTGCTGCAAGCCAGACAGGAAAAAGATTCCATGTCAGATAAGGCAACTGGGCTGGTCTTAC TTTGCATCACCTCTGCTTTCCTCCACTGCCATCATTAAACCTCAGCTGTGACATGAAAGACTTACCGGACCACTGAAGGTCTTCTGTAAAATATAATGAA GCTGAAACCTTTGGCCTAAGAAGAAAATGGAAGTATGTGCCACTCGATTTGTATTTCTGATTAACAAATAAACAGGGGTATTTCCTAAGGTGACCATGGT TGAACTTTAGCTCATGAAAGTGGAAACATTGGTTTAATTTTCAAGAGAATTAAGAAAGTAAAAGAGAAATTCTGTTATCAATAACTTGCAAGTAATTTTT TGTAAAAGATTGAATTACAGTAAACCCATCTTTCCTTAACGAAAATTTCCTATGTTTACAGTCTGTCTATTGGTATGCAATCTTGTAACTTTGATAATGA ACAGTGAGAGATTTTTAAATAAAGCCTCTAAATATGTTTTGTCATTTAATAACATACAGTTTTGTCACTTTTCAAGTACTTTCTGACTCACATACAGTAG ATCACTTTTTACTCTGTGTTACCATTTTGACTGGTCGTCATTGGCATGGGGTGGATATAGGGCATAGGATTACTTGTCTCAGAAGCTGTCATAGAATTTC TTGCTGCCAATTAAAAAACCTGTGTTCTTTACACACTACACGTATAAATATTGTAACTGTTCATCTTTGTTGTTTTATCACTGTAAGCCTGTCAAATCAT AGTATCCTAAGCATCTGTAAATGCTAATTTTGCATTTTTGGAAAAACCCATTCCTTCCAAGCTAGTGTTTTTCATTGGCTCCAGGTCTAATTTTTCACTG TGGTCCCTGGCAGCCAGTCTTTTGAAGTTTAAAGATTACCTGTCTCTTGACTGCAGTACCTTTTCTTTAATTTTTACCAAAAATATCCAGAGGTTACTGG AGTTCTTATTCAATATAAGGAAAGTTTGCTGCACTTTATTACCAAGCCTCTGGGATTTTACCAGTCAAACATATTTGTGCATTACATTTCATTTCTTGTG AGCTAGCTGGCTGTCCATATTGAATGTTGACCCATTTGAGTACGCTAAAAGGCTTACAGTATCAGACACGATCATGGTTTTAGATCCCATAATAAAAATG AATGTTTTTCTTATAAAAAATTATACAAATGCTGAAGTGAGATTCTACTATTGTTCATTGCTTCCTTTTCTTTTTCCTTTTGCGATTTTCACTGATTAAT AGCACATTTCTTCACAAAATTAGATAAAGTTGGTCAAAGACCAGATATTCTGGAATGGAAATTGTAAAGCTTAATCAAAAAGAATAGCCAGTACAGCATA CAATCTCAGAAACTTAGAAGCAAGTAGAAAATAATTGGTTGATGTAAACGAAAGTGCCATTTTAGTAAAGGCAGGAAAAAAATAGCAATATTTGAGTTAT GTAAGGATAAAAAATCCACTGACTTGTATTTTTGCACAAGAGGCTGGTCTGAATATGATTGTTCACATTAAGAGTGTTTATTCGTCGGTTCATTTTGGGG ATTTTCCCCCTTGATGTTTTGACAGATTGAAGTGAGCTTTAGTGAGCAAAAGGATCAGAATGCAGGGAACACTAAGCTGTGATGAAGAAAGTGTGGTAAA AAGCCAGAGTAGTTTTATACAGACAAAACCAGTGTCAGGCCTTTGCAGTAGGCTTGAGTGAACTTCTGATCTAGATTTGAAAGTAAATTTTATGAAGACA TTGCCCATTTTTACTTCCTCATTCATTATTGTACCAGCATCATAGCTTTATTACTCTAATCCCAGGTAAGTCAAGCCTACAATGCCCTAGAGGAAGAGTA AAACCAGAAATTCATGCTGGCTTAAATAATCTATTTTTGTTTCTTTTCATTTGAATATTTAAATTTTATGGTTTATTAAAAAATTAAATAAATGTTGTGT CCGTCTTTATTTAAAACAAGTTACCTGTTGATAAAATCATTAAAATTTCCTTAGTCAC

APG5L.u.f.9 (forward primer)
APG5L.u.r.5 (reverse primer)
Single exon skipping

Frame 0

ARPAAMAGEGGSSGQGGVGETPARSPGAGWRVW PAGSLLGYMSVAY*VWLWLK*EFSLYVLL*LLEE *QMTKMCFEMCGLDEFQLVSRYIRMR*LKGKQN HTICFCQE*VI*RW*LTK*KSTFRRL*DKKTLV RYGLNMKAHH*NGIIQLVCYLIFLHQVQLFLGTS QYILRVFQKKTFCTVHLRMQLKLILCHV*KKLM L*NIKVK*SMKCRKKITSNSGWDCKMTDLTSFG PSIGNSWNILQKKMDFVISPLEYIRQRLKDLSFR SCFVLWLQMDSCTH*EISSKKFVLLLLILKMGK KRIK**FMELSQCWKHLCSG*VNI*ATRIIFFI LVSSHSQQIEGSTICLNRIILKWDLSEHVTLLLQ SGLVEAT*PETLRCCKPDRKKIPCQIRQLGWSY FASPLLSSTAIIKPQL*HERLTGPLKVFCKI** S*NLWPKKKMEVCATRFVFLINK*TGVFPKVTMV EL*LMKVETLV*FSRELRK*KRNSVINNLQVIF CKRLNYSKPIFP*RKFPMFTVCLLVCNLVTLIM NSERFLNKASKYVLSFNNIQFCHFSSTF*LTYSR SLFTLCYHFDWSSLAWGGYRA*DYLSQKLS*NF LLPIKKPVFFTHYTYKYCNCSSLLFYHCKPVKS *YPKHL*MLILHFWKNPFLPS*CFSLAPGLIFHC GPWQPVF*SLKITCLLTAVPFL*FLPKISRGYW SSYSI*GKFAALYYQASGILPVKHICALHFISC ELAGCPY*MLTHLSTLKGLQYQTRSWF*IP**K* MFFL*KIIQMLK*DSTIVHCFLFFFLLRFSLIN STFLHKIR*SWSKTRYSGMEIVKLNQKE*PVQH TISET*KQVENNWLM*TKVPF**RQEKNSNI*VM *G*KIH*LVFLHKRLV*I*LFTLRVFIRRFILG IFPLDVLTD*SEL**AKGSECREH*AVMKKVW* KARVVLYRQNQCQAFAVGLSELLI*I*K*IL*RH CPFLLPHSLLYQHHSFITLIPGKSSLQCPRGRV KPEIHAGLNNLFLFLFI*IFKFYGLLKN*INVV SVFI*NKLPVDKIIKISLV

Frame 1

PARPRWRVKVVPPGKVELARRRPGALGPVGGCG LRGPSWGTCLLLTKFGFG*NKNLACMYCFNSWK NDR*QRCASRCVVWTNSNLFHAISG*DN*KGSRT ILFAFAKSKLFDVGN*QSEKALSEGYETRRH** DMV*I*RHTTEMALSNWFAI*SSCIKFSSSLEH HSTF*EFSRKRPSALSI*GCN*SSFYVMYERS*C FKT*KSSNQ*NAEKRSQATLDGIAK*QI*PVLG HQSETHGISCRRKWISLYPL*NISDND*KTFHS EAVSSCGCRWTVAHTRRSPQRSLSFCY*S*RWGK KESSDDSWN*ANVGNTSAVAE*TSELPG*FSSY *YHPTANRLKDQLFA*TESSLNGIYQSMSPFCF NQVWWRQPDQKHFAAASQTGKRFHVR*GNWAGLT LHHLCFPPLPSLNLSCDMKDLPDH*RSSVKYNE AETFGLRRKWKYVPLDLYF*LTNKQGYFLR*PW LNFSS*KWKHWFNFQEN*ESKREILLSITCK*FF VKD*ITVNPSFLNENFLCLQSVYWYAIL*L*** TVRDF*IKPLNMFCHLITYSFVTFQVLSDSHTV DHFLLCVTILTGRHWHGVDIGHRITCLRSCHRIS CCQLKNLCSLHTTRINIVTVHLCCFITVSLSNH SILSICKC*FCIFGKTHSFQASVFHWLQV*FFT VVPGSQSFEV*RLPVS*LQYLFFNFYQKYPEVTG VLIQYKESLLHFITKPLGFYQSNIFVHYISFLV S*LAVHIEC*PI*VR*KAYSIRHDHGFRSHNKN ECFSYKKLYKC*SEILLLFIASFSFSFCDFH*LI AHFFTKLDKVGQRPDILEWKL*SLIKKNSQYSI QSQKLRSK*KIIG*CKRKCHFSKGRKKIAIFEL CKDKKSTDLYFCTRGWSEYDCSH*ECLFVGSFWG FSPLMF*QIEVSFSEQKDQNAGNTKL**RKCGK KPE*FYTDKTSVRPLQ*A*VNF*SRFESKFYED IAHFYFLIHYCTSIIALLL*SQVSQAYNALEEE* NQKFMLA*IIYFCFFSFEYLNFMVY*KIK*MLC PSLFKTSYLLIKSLKFP*S

Frame 2

PPGRDGG*RWFLRARWSWRDAGPEPWGRLAGVA CGVPLGVHVCCLLSLALVEIRI*PVCTALTPGR MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAE PYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDISE IWFEYEGTPLKWHYPIGLLFDLLASSSALPWNI TVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEAD ALKHKSQVINEMQKKDHKQLWMGLQNDRFDQFWA INRKLMEYPAEENGFRYIPFRIYQTTTERPFIQ KLFRPVAADGQLHTLGDLLKEVCPSAIDPEDGE KKNQVMIHGIEPMLETPLQWLSEHLSYPDNFLHI SIIPQPTD*RINYLPEQNHP*MGFIRACHPFAS IRFGGGNLTRNTSLLQARQEKDSMSDKATGLVL LCITSAFLHCHH*TSAVT*KTYRTTEGLL*NIMK LKPLA*EENGSMCHSICISD*QINRGIS*GDHG *TLAHESGNIGLIFKRIKKVKEKFCYQ*LASNF L*KIELQ*THLSLTKISYVYSLSIGMQSCNFDNE Q*EIFK*SL*ICFVI**HTVLSLFKYFLTHIQ* ITFYSVLPF*LVVIGMGWI*GIGLLVSEAVIEF LAAN*KTCVLYTLHV*IL*LFIFVVLSL*ACQII VS*ASVNANFAFLEKPIPSKLVFFIGSRSNFSL WSLAASLLKFKDYLSLDCSTFSLIFTKNIQRLL EFLFNIRKVCCTLLPSLWDFTSQTYLCITFHFL* ASWLSILNVDPFEYAKRLTVSDTIMVLDPIIKM NVFLIKNYTNAEVRFYYCSLLPFLFPFAIFTD* *HISSQN*IKLVKDQIFWNGNCKA*SKRIASTAY NLRNLEASRK*LVDVNESAILVKAGKK*QYLSY VRIKNPLTCIFAQEAGLNMIVHIKSVYSSVHFG DFPP*CFDRLK*ALVSKRIRMQGTLSCDEESVVK SQSSFIQTKPVSGLCSRLE*TSDLDLKVNFMKT LPIFTSSFIIVPAS*LYYSNPR*VKPTMP*RKS KTRNSCWLK*SIFVSFHLNI*ILWFIKKLNKCCV RLYLKQVTC**NH*NFLSH

Sequence APG5L.aAug05

GTGACGTCATCTCCGGGCGCCGAGGGTGACTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAA GTGCAGCAGGGTTCAGCTCCGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAG GCGGGCAGCTTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTGG CTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAAT TCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATTTGCTTTTGCCAAGAGTAAGTTATTTGACGTTGGTAACT GACAAAGTGAAAAAGCACTTTCAGAAGGTTATGAGACAAGAAGACATTAGTGAGATATGGTTTGAATATGAAGGCACACCACTGAAATGGCATTATCCAA TTGGTTTGCTATTTGATCTTCTTGCATCAAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCC ATCTAAGGATGCAATTGAAGCTCATTTTATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGAT CACAAGCAACTCTGGATGGGATTGCAAAATGACAGATTTGACCAGTTTTGGGCCATCAATCGGAAACTCATGGAATATCCTGCAGAAGAAAATGGATTTC GTTATATCCCCTTTAGAATATATCAGACAACGACTGAAAGACCTTTCATTCAGAAGCTGTTTCGTCCTGTGGCTGCAGATGGACAGTTGCACACACTAGG AGATCTCCTCAAAGAAGTTTGTCCTTCTGCTATTGATCCTGAAGATGGGGAAAAAAAGAATCAAGTGATGATTCATGGAATTGAGCCAATGTTGGAAACA CCTCTGCAGTGGCTGAGTGAACATCTGAGCTACCCGGATAATTTTCTTCATATTAGTATCATCCCACAGCCAACAGATTGAAGGATCAACTATTTGCCTG AACAGAATCATCCTTAAATGGGATTTATCAGAGCATGTCACCCTTTTGCTTCAATCAGGTTTGGTGGAGGCAACCTGACCAGAAACACTTCGCTGCTGCA AGCCAGACAGGAAAAAGATTCCATGTCAGATAAGGCAACTGGGCTGGTCTTACTTTGCATCACCTCTGCTTTCCTCCACTGCCATCATTAAACCTCAGCT GTGACATGAAAGACTTACCGGACCACTGAAGGTCTTCTGTAAAATATAATGAAGCTGAAACCTTTGGCCTAAGAAGAAAATGGAAGTATGTGCCACTCGA TTTGTATTTCTGATTAACAAATAAACAGGGGTATTTCCTAAGGTGACCATGGTTGAACTTTAGCTCATGAAAGTGGAAACATTGGTTTAATTTTCAAGAG AATTAAGAAAGTAAAAGAGAAATTCTGTTATCAATAACTTGCAAGTAATTTTTTGTAAAAGATTGAATTACAGTAAACCCATCTTTCCTTAACGAAAATT TCCTATGTTTACAGTCTGTCTATTGGTATGCAATCTTGTAACTTTGATAATGAACAGTGAGAGATTTTTAAATAAAGCCTCTAAATATGTTTTGTCATTT AATAACATACAGTTTTGTCACTTTTCAAGTACTTTCTGACTCACATACAGTAGATCACTTTTTACTCTGTGTTACCATTTTGACTGGTCGTCATTGGCAT GGGGTGGATATAGGGCATAGGATTACTTGTCTCAGAAGCTGTCATAGAATTTCTTGCTGCCAATTAAAAAACCTGTGTTCTTTACACACTACACGTATAA ATATTGTAACTGTTCATCTTTGTTGTTTTATCACTGTAAGCCTGTCAAATCATAGTATCCTAAGCATCTGTAAATGCTAATTTTGCATTTTTGGAAAAAC CCATTCCTTCCAAGCTAGTGTTTTTCATTGGCTCCAGGTCTAATTTTTCACTGTGGTCCCTGGCAGCCAGTCTTTTGAAGTTTAAAGATTACCTGTCTCT TGACTGCAGTACCTTTTCTTTAATTTTTACCAAAAATATCCAGAGGTTACTGGAGTTCTTATTCAATATAAGGAAAGTTTGCTGCACTTTATTACCAAGC CTCTGGGATTTTACCAGTCAAACATATTTGTGCATTACATTTCATTTCTTGTGAGCTAGCTGGCTGTCCATATTGAATGTTGACCCATTTGAGTACGCTA AAAGGCTTACAGTATCAGACACGATCATGGTTTTAGATCCCATAATAAAAATGAATGTTTTTCTTATAAAAAATTATACAAATGCTGAAGTGAGATTCTA CTATTGTTCATTGCTTCCTTTTCTTTTTCCTTTTGCGATTTTCACTGATTAATAGCACATTTCTTCACAAAATTAGATAAAGTTGGTCAAAGACCAGATA TTCTGGAATGGAAATTGTAAAGCTTAATCAAAAAGAATAGCCAGTACAGCATACAATCTCAGAAACTTAGAAGCAAGTAGAAAATAATTGGTTGATGTAA ACGAAAGTGCCATTTTAGTAAAGGCAGGAAAAAAATAGCAATATTTGAGTTATGTAAGGATAAAAAATCCACTGACTTGTATTTTTGCACAAGAGGCTGG TCTGAATATGATTGTTCACATTAAGAGTGTTTATTCGTCGGTTCATTTTGGGGATTTTCCCCCTTGATGTTTTGACAGATTGAAGTGAGCTTTAGTGAGC AAAAGGATCAGAATGCAGGGAACACTAAGCTGTGATGAAGAAAGTGTGGTAAAAAGCCAGAGTAGTTTTATACAGACAAAACCAGTGTCAGGCCTTTGCA GTAGGCTTGAGTGAACTTCTGATCTAGATTTGAAAGTAAATTTTATGAAGACATTGCCCATTTTTACTTCCTCATTCATTATTGTACCAGCATCATAGCT TTATTACTCTAATCCCAGGTAAGTCAAGCCTACAATGCCCTAGAGGAAGAGTAAAACCAGAAATTCATGCTGGCTTAAATAATCTATTTTTGTTTCTTTT CATTTGAATATTTAAATTTTATGGTTTATTAAAAAATTAAATAAATGTTGTGTCCGTCTTTATTTAAAACAAGTTACCTGTTGATAAAATCATTAAAATT TCCTTAGTCAC

APG5L.u.f.9 (forward primer)
APG5L.u.r.5 (reverse primer)
Single exon skipping

Frame 0

VTSSPGAEGDWTCGALPGLRSVAGCIRWIPEGG SAAGFSSDLRAGAFCGCAGFLESCYRVPAGQCVR RAACPAAPPERGIWASPPVRGAGRRSHSLE*VW LWLK*EFSLYVLL*LLEE*QMTKMCFEMCGLDE FQLVSRYIRMR*LKGKQNHTICFCQE*VI*RW*L TK*KSTFRRL*DKKTLVRYGLNMKAHH*NGIIQ LVCYLIFLHQVQLFLGTSQYILRVFQKKTFCTV HLRMQLKLILCHV*KKLML*NIKVK*SMKCRKKI TSNSGWDCKMTDLTSFGPSIGNSWNILQKKMDF VISPLEYIRQRLKDLSFRSCFVLWLQMDSCTH* EISSKKFVLLLLILKMGKKRIK**FMELSQCWKH LCSG*VNI*ATRIIFFILVSSHSQQIEGSTICL NRIILKWDLSEHVTLLLQSGLVEAT*PETLRCC KPDRKKIPCQIRQLGWSYFASPLLSSTAIIKPQL *HERLTGPLKVFCKI**S*NLWPKKKMEVCATR FVFLINK*TGVFPKVTMVEL*LMKVETLV*FSR ELRK*KRNSVINNLQVIFCKRLNYSKPIFP*RKF PMFTVCLLVCNLVTLIMNSERFLNKASKYVLSF NNIQFCHFSSTF*LTYSRSLFTLCYHFDWSSLA WGGYRA*DYLSQKLS*NFLLPIKKPVFFTHYTYK YCNCSSLLFYHCKPVKS*YPKHL*MLILHFWKN PFLPS*CFSLAPGLIFHCGPWQPVF*SLKITCL LTAVPFL*FLPKISRGYWSSYSI*GKFAALYYQA SGILPVKHICALHFISCELAGCPY*MLTHLSTL KGLQYQTRSWF*IP**K*MFFL*KIIQMLK*DS TIVHCFLFFFLLRFSLINSTFLHKIR*SWSKTRY SGMEIVKLNQKE*PVQHTISET*KQVENNWLM* TKVPF**RQEKNSNI*VM*G*KIH*LVFLHKRL V*I*LFTLRVFIRRFILGIFPLDVLTD*SEL**A KGSECREH*AVMKKVW*KARVVLYRQNQCQAFA VGLSELLI*I*K*IL*RHCPFLLPHSLLYQHHS FITLIPGKSSLQCPRGRVKPEIHAGLNNLFLFLF I*IFKFYGLLKN*INVVSVFI*NKLPVDKIIKI SLV

Frame 1

*RHLRAPRVTGLVVRCQGSAALPVVFAGYQRAE VQQGSAPTSAPVLFAAARASWSPATASPQDSVS GGQLAPPPHRSAESGRPHQCGEPEGGAIAWSRFG FG*NKNLACMYCFNSWKNDR*QRCASRCVVWTN SNLFHAISG*DN*KGSRTILFAFAKSKLFDVGN *QSEKALSEGYETRRH**DMV*I*RHTTEMALSN WFAI*SSCIKFSSSLEHHSTF*EFSRKRPSALS I*GCN*SSFYVMYERS*CFKT*KSSNQ*NAEKR SQATLDGIAK*QI*PVLGHQSETHGISCRRKWIS LYPL*NISDND*KTFHSEAVSSCGCRWTVAHTR RSPQRSLSFCY*S*RWGKKESSDDSWN*ANVGN TSAVAE*TSELPG*FSSY*YHPTANRLKDQLFA* TESSLNGIYQSMSPFCFNQVWWRQPDQKHFAAA SQTGKRFHVR*GNWAGLTLHHLCFPPLPSLNLS CDMKDLPDH*RSSVKYNEAETFGLRRKWKYVPLD LYF*LTNKQGYFLR*PWLNFSS*KWKHWFNFQE N*ESKREILLSITCK*FFVKD*ITVNPSFLNEN FLCLQSVYWYAIL*L***TVRDF*IKPLNMFCHL ITYSFVTFQVLSDSHTVDHFLLCVTILTGRHWH GVDIGHRITCLRSCHRISCCQLKNLCSLHTTRI NIVTVHLCCFITVSLSNHSILSICKC*FCIFGKT HSFQASVFHWLQV*FFTVVPGSQSFEV*RLPVS *LQYLFFNFYQKYPEVTGVLIQYKESLLHFITK PLGFYQSNIFVHYISFLVS*LAVHIEC*PI*VR* KAYSIRHDHGFRSHNKNECFSYKKLYKC*SEIL LLFIASFSFSFCDFH*LIAHFFTKLDKVGQRPD ILEWKL*SLIKKNSQYSIQSQKLRSK*KIIG*CK RKCHFSKGRKKIAIFELCKDKKSTDLYFCTRGW SEYDCSH*ECLFVGSFWGFSPLMF*QIEVSFSE QKDQNAGNTKL**RKCGKKPE*FYTDKTSVRPLQ *A*VNF*SRFESKFYEDIAHFYFLIHYCTSIIA LLL*SQVSQAYNALEEE*NQKFMLA*IIYFCFF SFEYLNFMVY*KIK*MLCPSLFKTSYLLIKSLKF P*S

Frame 2

DVISGRRG*LDLWCAARAPQRCRLYSLDTRGRK CSRVQLRPPRRCFLRLRGLPGVLLPRPRRTVCQ AGSLPRRPTGARNLGVPTSAGSRKEEP*LGVGL ALVEIRI*PVCTALTPGRMTDDKDVLRDVWFGRI PTCFTLYQDEITEREAEPYYLLLPRVSYLTLVT DKVKKHFQKVMRQEDISEIWFEYEGTPLKWHYP IGLLFDLLASSSALPWNITVHFKSFPEKDLLHCP SKDAIEAHFMSCMKEADALKHKSQVINEMQKKD HKQLWMGLQNDRFDQFWAINRKLMEYPAEENGF RYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLG DLLKEVCPSAIDPEDGEKKNQVMIHGIEPMLET PLQWLSEHLSYPDNFLHISIIPQPTD*RINYLP EQNHP*MGFIRACHPFASIRFGGGNLTRNTSLLQ ARQEKDSMSDKATGLVLLCITSAFLHCHH*TSA VT*KTYRTTEGLL*NIMKLKPLA*EENGSMCHS ICISD*QINRGIS*GDHG*TLAHESGNIGLIFKR IKKVKEKFCYQ*LASNFL*KIELQ*THLSLTKI SYVYSLSIGMQSCNFDNEQ*EIFK*SL*ICFVI **HTVLSLFKYFLTHIQ*ITFYSVLPF*LVVIGM GWI*GIGLLVSEAVIEFLAAN*KTCVLYTLHV* IL*LFIFVVLSL*ACQIIVS*ASVNANFAFLEK PIPSKLVFFIGSRSNFSLWSLAASLLKFKDYLSL DCSTFSLIFTKNIQRLLEFLFNIRKVCCTLLPS LWDFTSQTYLCITFHFL*ASWLSILNVDPFEYA KRLTVSDTIMVLDPIIKMNVFLIKNYTNAEVRFY YCSLLPFLFPFAIFTD**HISSQN*IKLVKDQI FWNGNCKA*SKRIASTAYNLRNLEASRK*LVDV NESAILVKAGKK*QYLSYVRIKNPLTCIFAQEAG LNMIVHIKSVYSSVHFGDFPP*CFDRLK*ALVS KRIRMQGTLSCDEESVVKSQSSFIQTKPVSGLC SRLE*TSDLDLKVNFMKTLPIFTSSFIIVPAS*L YYSNPR*VKPTMP*RKSKTRNSCWLK*SIFVSF HLNI*ILWFIKKLNKCCVRLYLKQVTC**NH*N FLSH