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Sequences

Sequence APG5L.eAug05

GTGACGTCATCTCCGGGCGCCGAGGGTGACTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAA
GTGCAGCAGGGTTCAGCTCCGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAG
GCGGGCAGCTTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTGG
CTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAAT
TCCAACTTGTTTCACG
CTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATGCATTATCCAATTGGTTTGCTATTTGATCTTCTTGCATC
AAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCCATCTAAGGATGCAATTGAAGCTCATTTT
ATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAA
ATGACAGATTTGACCAGTTTTGGGCCATCAATCGGAAACTCATGGAATATCCTGCAGAAGAAAATGGATTTCGTTATATCCCCTTTAGAATATATCAGAC
AACGACTGAAAGACCTTTCATTCAGAAGCTGTTTCGTCCTGTGGCTGCAGATGGACAGTTGCACACACTAGGAGATCTCCTCAAAGAAGTTTGTCCTTCT
GCTATTGATCCTGAAGGTAATACAATCAGCAACATTAAAACATTTCTTTCATTTTCTGTTACTGAAGTAAAATAAGCATTCCACATTTATAAACAACAGG
TTATTTCAGGAAGATATTTTCATATCTTACAGCGAAAAGTCTTTTCAAACAGAAGCACCTAATATTTAATATATTATTTTGTAAATTATTGACTAACAAA
ATGATGACTCGACTGGCGAAATAAAATACAGTTTTTAAATCAT
  • apg5l.f.1 (forward primer)
  • apg5l.r.4 (reverse primer)
  • Single exon skipping

Frame 0

VTSSPGAEGDWTCGALPGLRSVAGCIRWIPEGG
SAAGFSSDLRAGAFCGCAGFLESCYRVPAGQCVR
RAACPAAPPERGIWASPPVRGAGRRSHSLE*VW
LWLK*EFSLYVLL*LLEE*QMTKMCFEMCGLDE
FQLVSR
YIRMR*LKGKQNHTMHYPIGLLFDLLAS
SSALPWNITVHFKSFPEKDLLHCPSKDAIEAHF
MSCMKEADALKHKSQVINEMQKKDHKQLWMGLQ
NDRFDQFWAINRKLMEYPAEENGFRYIPFRIYQT
TTERPFIQKLFRPVAADGQLHTLGDLLKEVCPS
AIDPEGNTISNIKTFLSFSVTEVK*AFHIYKQQ
VISGRYFHILQRKVFSNRST*YLIYYFVNY*LTK
**LDWRNKIQFLNH

Frame 1

*RHLRAPRVTGLVVRCQGSAALPVVFAGYQRAE
VQQGSAPTSAPVLFAAARASWSPATASPQDSVS
GGQLAPPPHRSAESGRPHQCGEPEGGAIAWSRFG
FG*NKNLACMYCFNSWKNDR*QRCASRCVVWTN
SNLFH
AISG*DN*KGSRTILCIIQLVCYLIFLH
QVQLFLGTSQYILRVFQKKTFCTVHLRMQLKLIL
CHV*KKLML*NIKVK*SMKCRKKITSNSGWDCK
MTDLTSFGPSIGNSWNILQKKMDFVISPLEYIR
QRLKDLSFRSCFVLWLQMDSCTH*EISSKKFVLL
LLILKVIQSATLKHFFHFLLLK*NKHSTFINNR
LFQEDIFISYSEKSFQTEAPNI*YIIL*IID*Q
NDDSTGEIKYSF*I

Frame 2

DVISGRRG*LDLWCAARAPQRCRLYSLDTRGRK
CSRVQLRPPRRCFLRLRGLPGVLLPRPRRTVCQ
AGSLPRRPTGARNLGVPTSAGSRKEEP*LGVGL
ALVEIRI*PVCTALTPGRMTDDKDVLRDVWFGRI
PTCFT
LYQDEITEREAEPYYALSNWFAI*SSCI
KFSSSLEHHSTF*EFSRKRPSALSI*GCN*SSF
YVMYERS*CFKT*KSSNQ*NAEKRSQATLDGIAK
*QI*PVLGHQSETHGISCRRKWISLYPL*NISD
ND*KTFHSEAVSSCGCRWTVAHTRRSPQRSLSF
CY*S*R*YNQQH*NISFIFCY*SKISIPHL*TTG
YFRKIFSYLTAKSLFKQKHLIFNILFCKLLTNK
MMTRLAK*NTVFKS

Sequence APG5L.cAug05

GTGACGTCATCTCCGGGCGCCGAGGGTGACTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAA
GTGCAGCAGGGTTCAGCTCCGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAG
GCGGGCAGCTTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTGG
CTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAAT
TCCAACTTGTTTCACG
CTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATGCATTATCCAATTGGTTTGCTATTTGATCTTCTTGCATC
AAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCCATCTAAGGATGCAATTGAAGCTCATTTT
ATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAA
ATGACAGATTTGACCAGTTTTGGGCCATCAATCGGAAACTCATGGAATATCCTGCAGAAGAAAATGGATTTCGTTATATCCCCTTTAGAATATATCAGAC
AACGACTGAAAGACCTTTCATTCAGAAGCTGTTTCGTCCTGTGGCTGCAGATGGACAGTTGCACACACTAGGAGATCTCCTCAAAGAAGTTTGTCCTTCT
GCTATTGATCCTGAAGATGGGGAAAAAAAGAATCAAGTGATGATTCATGGAATTGAGCCAATGTTGGAAACACCTCTGCAGTGGCTGAGTGAACATCTGA
GCTACCCGGATAATTTTCTTCATATTAGTATCATCCCACAGCCAACAGATTGAAGGATCAACTATTTGCCTGAACAGAATCATCCTTAAATGGGATTTAT
CAGAGCATGTCACCCTTTTGCTTCAATCAGGTTTGGTGGAGGCAACCTGACCAGAAACACTTCGCTGCTGCAAGCCAGACAGGAAAAAGATTCCATGTCA
GATAAGGCAACTGGGCTGGTCTTACTTTGCATCACCTCTGCTTTCCTCCACTGCCATCATTAAACCTCAGCTGTGACATGAAAGACTTACCGGACCACTG
AAGGTCTTCTGTAAAATATAATGAAGCTGAAACCTTTGGCCTAAGAAGAAAATGGAAGTATGTGCCACTCGATTTGTATTTCTGATTAACAAATAAACAG
GGGTATTTCCTAAGGTGACCATGGTTGAACTTTAGCTCATGAAAGTGGAAACATTGGTTTAATTTTCAAGAGAATTAAGAAAGTAAAAGAGAAATTCTGT
TATCAATAACTTGCAAGTAATTTTTTGTAAAAGATTGAATTACAGTAAACCCATCTTTCCTTAACGAAAATTTCCTATGTTTACAGTCTGTCTATTGGTA
TGCAATCTTGTAACTTTGATAATGAACAGTGAGAGATTTTTAAATAAAGCCTCTAAATATGTTTTGTCATTTAATAACATACAGTTTTGTCACTTTTCAA
GTACTTTCTGACTCACATACAGTAGATCACTTTTTACTCTGTGTTACCATTTTGACTGGTCGTCATTGGCATGGGGTGGATATAGGGCATAGGATTACTT
GTCTCAGAAGCTGTCATAGAATTTCTTGCTGCCAATTAAAAAACCTGTGTTCTTTACACACTACACGTATAAATATTGTAACTGTTCATCTTTGTTGTTT
TATCACTGTAAGCCTGTCAAATCATAGTATCCTAAGCATCTGTAAATGCTAATTTTGCATTTTTGGAAAAACCCATTCCTTCCAAGCTAGTGTTTTTCAT
TGGCTCCAGGTCTAATTTTTCACTGTGGTCCCTGGCAGCCAGTCTTTTGAAGTTTAAAGATTACCTGTCTCTTGACTGCAGTACCTTTTCTTTAATTTTT
ACCAAAAATATCCAGAGGTTACTGGAGTTCTTATTCAATATAAGGAAAGTTTGCTGCACTTTATTACCAAGCCTCTGGGATTTTACCAGTCAAACATATT
TGTGCATTACATTTCATTTCTTGTGAGCTAGCTGGCTGTCCATATTGAATGTTGACCCATTTGAGTACGCTAAAAGGCTTACAGTATCAGACACGATCAT
GGTTTTAGATCCCATAATAAAAATGAATGTTTTTCTTATAAAAAATTATACAAATGCTGAAGTGAGATTCTACTATTGTTCATTGCTTCCTTTTCTTTTT
CCTTTTGCGATTTTCACTGATTAATAGCACATTTCTTCACAAAATTAGATAAAGTTGGTCAAAGACCAGATATTCTGGAATGGAAATTGTAAAGCTTAAT
CAAAAAGAATAGCCAGTACAGCATACAATCTCAGAAACTTAGAAGCAAGTAGAAAATAATTGGTTGATGTAAACGAAAGTGCCATTTTAGTAAAGGCAGG
AAAAAAATAGCAATATTTGAGTTATGTAAGGATAAAAAATCCACTGACTTGTATTTTTGCACAAGAGGCTGGTCTGAATATGATTGTTCACATTAAGAGT
GTTTATTCGTCGGTTCATTTTGGGGATTTTCCCCCTTGATGTTTTGACAGATTGAAGTGAGCTTTAGTGAGCAAAAGGATCAGAATGCAGGGAACACTAA
GCTGTGATGAAGAAAGTGTGGTAAAAAGCCAGAGTAGTTTTATACAGACAAAACCAGTGTCAGGCCTTTGCAGTAGGCTTGAGTGAACTTCTGATCTAGA
TTTGAAAGTAAATTTTATGAAGACATTGCCCATTTTTACTTCCTCATTCATTATTGTACCAGCATCATAGCTTTATTACTCTAATCCCAGGTAAGTCAAG
CCTACAATGCCCTAGAGGAAGAGTAAAACCAGAAATTCATGCTGGCTTAAATAATCTATTTTTGTTTCTTTTCATTTGAATATTTAAATTTTATGGTTTA
TTAAAAAATTAAATAAATGTTGTGTCCGTCTTTATTTAAAACAAGTTACCTGTTGATAAAATCATTAAAATTTCCTTAGTCAC
  • apg5l.f.1 (forward primer)
  • apg5l.r.4 (reverse primer)
  • Single exon skipping

Frame 0

VTSSPGAEGDWTCGALPGLRSVAGCIRWIPEGG
SAAGFSSDLRAGAFCGCAGFLESCYRVPAGQCVR
RAACPAAPPERGIWASPPVRGAGRRSHSLE*VW
LWLK*EFSLYVLL*LLEE*QMTKMCFEMCGLDE
FQLVSR
YIRMR*LKGKQNHTMHYPIGLLFDLLAS
SSALPWNITVHFKSFPEKDLLHCPSKDAIEAHF
MSCMKEADALKHKSQVINEMQKKDHKQLWMGLQ
NDRFDQFWAINRKLMEYPAEENGFRYIPFRIYQT
TTERPFIQKLFRPVAADGQLHTLGDLLKEVCPS
AIDPEDGEKKNQVMIHGIEPMLETPLQWLSEHL
SYPDNFLHISIIPQPTD*RINYLPEQNHP*MGFI
RACHPFASIRFGGGNLTRNTSLLQARQEKDSMS
DKATGLVLLCITSAFLHCHH*TSAVT*KTYRTT
EGLL*NIMKLKPLA*EENGSMCHSICISD*QINR
GIS*GDHG*TLAHESGNIGLIFKRIKKVKEKFC
YQ*LASNFL*KIELQ*THLSLTKISYVYSLSIG
MQSCNFDNEQ*EIFK*SL*ICFVI**HTVLSLFK
YFLTHIQ*ITFYSVLPF*LVVIGMGWI*GIGLL
VSEAVIEFLAAN*KTCVLYTLHV*IL*LFIFVV
LSL*ACQIIVS*ASVNANFAFLEKPIPSKLVFFI
GSRSNFSLWSLAASLLKFKDYLSLDCSTFSLIF
TKNIQRLLEFLFNIRKVCCTLLPSLWDFTSQTY
LCITFHFL*ASWLSILNVDPFEYAKRLTVSDTIM
VLDPIIKMNVFLIKNYTNAEVRFYYCSLLPFLF
PFAIFTD**HISSQN*IKLVKDQIFWNGNCKA*
SKRIASTAYNLRNLEASRK*LVDVNESAILVKAG
KK*QYLSYVRIKNPLTCIFAQEAGLNMIVHIKS
VYSSVHFGDFPP*CFDRLK*ALVSKRIRMQGTL
SCDEESVVKSQSSFIQTKPVSGLCSRLE*TSDLD
LKVNFMKTLPIFTSSFIIVPAS*LYYSNPR*VK
PTMP*RKSKTRNSCWLK*SIFVSFHLNI*ILWF
IKKLNKCCVRLYLKQVTC**NH*NFLSH

Frame 1

*RHLRAPRVTGLVVRCQGSAALPVVFAGYQRAE
VQQGSAPTSAPVLFAAARASWSPATASPQDSVS
GGQLAPPPHRSAESGRPHQCGEPEGGAIAWSRFG
FG*NKNLACMYCFNSWKNDR*QRCASRCVVWTN
SNLFH
AISG*DN*KGSRTILCIIQLVCYLIFLH
QVQLFLGTSQYILRVFQKKTFCTVHLRMQLKLIL
CHV*KKLML*NIKVK*SMKCRKKITSNSGWDCK
MTDLTSFGPSIGNSWNILQKKMDFVISPLEYIR
QRLKDLSFRSCFVLWLQMDSCTH*EISSKKFVLL
LLILKMGKKRIK**FMELSQCWKHLCSG*VNI*
ATRIIFFILVSSHSQQIEGSTICLNRIILKWDL
SEHVTLLLQSGLVEAT*PETLRCCKPDRKKIPCQ
IRQLGWSYFASPLLSSTAIIKPQL*HERLTGPL
KVFCKI**S*NLWPKKKMEVCATRFVFLINK*T
GVFPKVTMVEL*LMKVETLV*FSRELRK*KRNSV
INNLQVIFCKRLNYSKPIFP*RKFPMFTVCLLV
CNLVTLIMNSERFLNKASKYVLSFNNIQFCHFS
STF*LTYSRSLFTLCYHFDWSSLAWGGYRA*DYL
SQKLS*NFLLPIKKPVFFTHYTYKYCNCSSLLF
YHCKPVKS*YPKHL*MLILHFWKNPFLPS*CFS
LAPGLIFHCGPWQPVF*SLKITCLLTAVPFL*FL
PKISRGYWSSYSI*GKFAALYYQASGILPVKHI
CALHFISCELAGCPY*MLTHLSTLKGLQYQTRS
WF*IP**K*MFFL*KIIQMLK*DSTIVHCFLFFF
LLRFSLINSTFLHKIR*SWSKTRYSGMEIVKLN
QKE*PVQHTISET*KQVENNWLM*TKVPF**RQ
EKNSNI*VM*G*KIH*LVFLHKRLV*I*LFTLRV
FIRRFILGIFPLDVLTD*SEL**AKGSECREH*
AVMKKVW*KARVVLYRQNQCQAFAVGLSELLI*
I*K*IL*RHCPFLLPHSLLYQHHSFITLIPGKSS
LQCPRGRVKPEIHAGLNNLFLFLFI*IFKFYGL
LKN*INVVSVFI*NKLPVDKIIKISLV

Frame 2

DVISGRRG*LDLWCAARAPQRCRLYSLDTRGRK
CSRVQLRPPRRCFLRLRGLPGVLLPRPRRTVCQ
AGSLPRRPTGARNLGVPTSAGSRKEEP*LGVGL
ALVEIRI*PVCTALTPGRMTDDKDVLRDVWFGRI
PTCFT
LYQDEITEREAEPYYALSNWFAI*SSCI
KFSSSLEHHSTF*EFSRKRPSALSI*GCN*SSF
YVMYERS*CFKT*KSSNQ*NAEKRSQATLDGIAK
*QI*PVLGHQSETHGISCRRKWISLYPL*NISD
ND*KTFHSEAVSSCGCRWTVAHTRRSPQRSLSF
CY*S*RWGKKESSDDSWN*ANVGNTSAVAE*TSE
LPG*FSSY*YHPTANRLKDQLFA*TESSLNGIY
QSMSPFCFNQVWWRQPDQKHFAAASQTGKRFHV
R*GNWAGLTLHHLCFPPLPSLNLSCDMKDLPDH*
RSSVKYNEAETFGLRRKWKYVPLDLYF*LTNKQ
GYFLR*PWLNFSS*KWKHWFNFQEN*ESKREIL
LSITCK*FFVKD*ITVNPSFLNENFLCLQSVYWY
AIL*L***TVRDF*IKPLNMFCHLITYSFVTFQ
VLSDSHTVDHFLLCVTILTGRHWHGVDIGHRIT
CLRSCHRISCCQLKNLCSLHTTRINIVTVHLCCF
ITVSLSNHSILSICKC*FCIFGKTHSFQASVFH
WLQV*FFTVVPGSQSFEV*RLPVS*LQYLFFNF
YQKYPEVTGVLIQYKESLLHFITKPLGFYQSNIF
VHYISFLVS*LAVHIEC*PI*VR*KAYSIRHDH
GFRSHNKNECFSYKKLYKC*SEILLLFIASFSF
SFCDFH*LIAHFFTKLDKVGQRPDILEWKL*SLI
KKNSQYSIQSQKLRSK*KIIG*CKRKCHFSKGR
KKIAIFELCKDKKSTDLYFCTRGWSEYDCSH*E
CLFVGSFWGFSPLMF*QIEVSFSEQKDQNAGNTK
L**RKCGKKPE*FYTDKTSVRPLQ*A*VNF*SR
FESKFYEDIAHFYFLIHYCTSIIALLL*SQVSQ
AYNALEEE*NQKFMLA*IIYFCFFSFEYLNFMVY
*KIK*MLCPSLFKTSYLLIKSLKFP*S

Sequence APG5L.dAug05

TGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAATTCCAACTTGTTTCACGCTATATCAG
GATGAGATAACTGAAAGGGAAGCAGAACCATACTATTTGCTTTTGCCAAGAGTAAGTTATTTGACGTTGGTAACTGACAAAGTGAAAAAGCACTTTCAGA
AGGTTATGAGACAAGAAGACATTAGTGAGATATGGTTTGAATATGAAGGCACACCACTGAAATG
GCATTATCCAATTGGTTTGCTATTTGATCTTCTTGC
ATCAAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCCATCTAAGGATGCAATTGAAGCTCAT
TTTATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGC
AAAATGATTTGACCAGTTTTGGGCCATCAATCGGAAACTCATGGAATATCCTGCAGAAGAAAATGGATTTCGTTATATCCCCTTTAGAATATATCAGGTA
GGAAATAACATTTTAAAAAACATCCATTTATGAAAGCCTCAGACATCTTAATTGAAGCACTCTAGTGTAGAACTCTTTGTCTGCATAGTAACTAAACGGT
ATTTATTAGGGGTTTTCCAAACTGTGTCTTTCAGTGGCAATCAAGTCAGATACCGCACTGAAATATTTGACTCATATGCATTTGGTACTCAT
  • apg5l.f.1 (forward primer)
  • apg5l.r.4 (reverse primer)
  • Single exon skipping

Frame 0

CMYCFNSWKNDR*QRCASRCVVWTNSNLFHAIS
G*DN*KGSRTILFAFAKSKLFDVGN*QSEKALSE
GYETRRH**DMV*I*RHTTEM
ALSNWFAI*SSC
IKFSSSLEHHSTF*EFSRKRPSALSI*GCN*SS
FYVMYERS*CFKT*KSSNQ*NAEKRSQATLDGIA
K*FDQFWAINRKLMEYPAEENGFRYIPFRIYQV
GNNILKNIHL*KPQTS*LKHSSVELFVCIVTKR
YLLGVFQTVSFSGNQVRYRTEIFDSYAFGTH

Frame 1

VCTALTPGRMTDDKDVLRDVWFGRIPTCFTLYQ
DEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQ
KVMRQEDISEIWFEYEGTPLKW
HYPIGLLFDLLA
SSSALPWNITVHFKSFPEKDLLHCPSKDAIEAH
FMSCMKEADALKHKSQVINEMQKKDHKQLWMGL
QNDLTSFGPSIGNSWNILQKKMDFVISPLEYIR*
EITF*KTSIYESLRHLN*STLV*NSLSA**LNG
IY*GFSKLCLSVAIKSDTALKYLTHMHLVL

Frame 2

YVLL*LLEE*QMTKMCFEMCGLDEFQLVSRYIR
MR*LKGKQNHTICFCQE*VI*RW*LTK*KSTFR
RL*DKKTLVRYGLNMKAHH*N
GIIQLVCYLIFL
HQVQLFLGTSQYILRVFQKKTFCTVHLRMQLKLI
LCHV*KKLML*NIKVK*SMKCRKKITSNSGWDC
KMI*PVLGHQSETHGISCRRKWISLYPL*NISG
RK*HFKKHPFMKASDILIEAL*CRTLCLHSN*TV
FIRGFPNCVFQWQSSQIPH*NI*LICIWYS

Sequence APG5L.bAug05

GCCCGCCCGGCCGCGATGGCGGGTGAAGGTGGTTCCTCCGGGCAAGGTGGAGTTGGCGAGACGCCGGCCCGGAGCCCTGGGGCCGGTTGGCGGGTGTGGC
CTGCGGGGTCCCTCTTGGGGTACATGTCTGTTGCTTACTAAGTTTGGCTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGA
ATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAATTCCAACTTGTTTCACGCTATATCAGGATGAGATAACTGAAAGGGAAGCAGAAC
CATACTATTTGCTTTTGCCAAGAGTAAGTTATTTGACGTTGGTAACTGACAAAGTGAAAAAGCACTTTCAGAAGGTTATGAGACAAGAAGACATTAGTGA
GATATGGTTTGAATATGAAGGCACACCACTGAAATG
GCATTATCCAATTGGTTTGCTATTTGATCTTCTTGCATCAAGTTCAGCTCTTCCTTGGAACATC
ACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCCATCTAAGGATGCAATTGAAGCTCATTTTATGTCATGTATGAAAGAAGCTGATG
CTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGATCACAAGCAACTCTGGATGGGATTGCAAAATGACAGATTTGACCAGTTTTGGGC
CATCAATCGGAAACTCATGGAATATCCTGCAGAAGAAAATGGATTTCGTTATATCCCCTTTAGAATATATCAGACAACGACTGAAAGACCTTTCATTCAG
AAGCTGTTTCGTCCTGTGGCTGCAGATGGACAGTTGCACACACTAGGAGATCTCCTCAAAGAAGTTTGTCCTTCTGCTATTGATCCTGAAGATGGGGAAA
AAAAGAATCAAGTGATGATTCATGGAATTGAGCCAATGTTGGAAACACCTCTGCAGTGGCTGAGTGAACATCTGAGCTACCCGGATAATTTTCTTCATAT
TAGTATCATCCCACAGCCAACAGATTGAAGGATCAACTATTTGCCTGAACAGAATCATCCTTAAATGGGATTTATCAGAGCATGTCACCCTTTTGCTTCA
ATCAGGTTTGGTGGAGGCAACCTGACCAGAAACACTTCGCTGCTGCAAGCCAGACAGGAAAAAGATTCCATGTCAGATAAGGCAACTGGGCTGGTCTTAC
TTTGCATCACCTCTGCTTTCCTCCACTGCCATCATTAAACCTCAGCTGTGACATGAAAGACTTACCGGACCACTGAAGGTCTTCTGTAAAATATAATGAA
GCTGAAACCTTTGGCCTAAGAAGAAAATGGAAGTATGTGCCACTCGATTTGTATTTCTGATTAACAAATAAACAGGGGTATTTCCTAAGGTGACCATGGT
TGAACTTTAGCTCATGAAAGTGGAAACATTGGTTTAATTTTCAAGAGAATTAAGAAAGTAAAAGAGAAATTCTGTTATCAATAACTTGCAAGTAATTTTT
TGTAAAAGATTGAATTACAGTAAACCCATCTTTCCTTAACGAAAATTTCCTATGTTTACAGTCTGTCTATTGGTATGCAATCTTGTAACTTTGATAATGA
ACAGTGAGAGATTTTTAAATAAAGCCTCTAAATATGTTTTGTCATTTAATAACATACAGTTTTGTCACTTTTCAAGTACTTTCTGACTCACATACAGTAG
ATCACTTTTTACTCTGTGTTACCATTTTGACTGGTCGTCATTGGCATGGGGTGGATATAGGGCATAGGATTACTTGTCTCAGAAGCTGTCATAGAATTTC
TTGCTGCCAATTAAAAAACCTGTGTTCTTTACACACTACACGTATAAATATTGTAACTGTTCATCTTTGTTGTTTTATCACTGTAAGCCTGTCAAATCAT
AGTATCCTAAGCATCTGTAAATGCTAATTTTGCATTTTTGGAAAAACCCATTCCTTCCAAGCTAGTGTTTTTCATTGGCTCCAGGTCTAATTTTTCACTG
TGGTCCCTGGCAGCCAGTCTTTTGAAGTTTAAAGATTACCTGTCTCTTGACTGCAGTACCTTTTCTTTAATTTTTACCAAAAATATCCAGAGGTTACTGG
AGTTCTTATTCAATATAAGGAAAGTTTGCTGCACTTTATTACCAAGCCTCTGGGATTTTACCAGTCAAACATATTTGTGCATTACATTTCATTTCTTGTG
AGCTAGCTGGCTGTCCATATTGAATGTTGACCCATTTGAGTACGCTAAAAGGCTTACAGTATCAGACACGATCATGGTTTTAGATCCCATAATAAAAATG
AATGTTTTTCTTATAAAAAATTATACAAATGCTGAAGTGAGATTCTACTATTGTTCATTGCTTCCTTTTCTTTTTCCTTTTGCGATTTTCACTGATTAAT
AGCACATTTCTTCACAAAATTAGATAAAGTTGGTCAAAGACCAGATATTCTGGAATGGAAATTGTAAAGCTTAATCAAAAAGAATAGCCAGTACAGCATA
CAATCTCAGAAACTTAGAAGCAAGTAGAAAATAATTGGTTGATGTAAACGAAAGTGCCATTTTAGTAAAGGCAGGAAAAAAATAGCAATATTTGAGTTAT
GTAAGGATAAAAAATCCACTGACTTGTATTTTTGCACAAGAGGCTGGTCTGAATATGATTGTTCACATTAAGAGTGTTTATTCGTCGGTTCATTTTGGGG
ATTTTCCCCCTTGATGTTTTGACAGATTGAAGTGAGCTTTAGTGAGCAAAAGGATCAGAATGCAGGGAACACTAAGCTGTGATGAAGAAAGTGTGGTAAA
AAGCCAGAGTAGTTTTATACAGACAAAACCAGTGTCAGGCCTTTGCAGTAGGCTTGAGTGAACTTCTGATCTAGATTTGAAAGTAAATTTTATGAAGACA
TTGCCCATTTTTACTTCCTCATTCATTATTGTACCAGCATCATAGCTTTATTACTCTAATCCCAGGTAAGTCAAGCCTACAATGCCCTAGAGGAAGAGTA
AAACCAGAAATTCATGCTGGCTTAAATAATCTATTTTTGTTTCTTTTCATTTGAATATTTAAATTTTATGGTTTATTAAAAAATTAAATAAATGTTGTGT
CCGTCTTTATTTAAAACAAGTTACCTGTTGATAAAATCATTAAAATTTCCTTAGTCAC
  • apg5l.f.1 (forward primer)
  • apg5l.r.4 (reverse primer)
  • Single exon skipping

Frame 0

ARPAAMAGEGGSSGQGGVGETPARSPGAGWRVW
PAGSLLGYMSVAY*VWLWLK*EFSLYVLL*LLEE
*QMTKMCFEMCGLDEFQLVSRYIRMR*LKGKQN
HTICFCQE*VI*RW*LTK*KSTFRRL*DKKTLV
RYGLNMKAHH*N
GIIQLVCYLIFLHQVQLFLGTS
QYILRVFQKKTFCTVHLRMQLKLILCHV*KKLM
L*NIKVK*SMKCRKKITSNSGWDCKMTDLTSFG
PSIGNSWNILQKKMDFVISPLEYIRQRLKDLSFR
SCFVLWLQMDSCTH*EISSKKFVLLLLILKMGK
KRIK**FMELSQCWKHLCSG*VNI*ATRIIFFI
LVSSHSQQIEGSTICLNRIILKWDLSEHVTLLLQ
SGLVEAT*PETLRCCKPDRKKIPCQIRQLGWSY
FASPLLSSTAIIKPQL*HERLTGPLKVFCKI**
S*NLWPKKKMEVCATRFVFLINK*TGVFPKVTMV
EL*LMKVETLV*FSRELRK*KRNSVINNLQVIF
CKRLNYSKPIFP*RKFPMFTVCLLVCNLVTLIM
NSERFLNKASKYVLSFNNIQFCHFSSTF*LTYSR
SLFTLCYHFDWSSLAWGGYRA*DYLSQKLS*NF
LLPIKKPVFFTHYTYKYCNCSSLLFYHCKPVKS
*YPKHL*MLILHFWKNPFLPS*CFSLAPGLIFHC
GPWQPVF*SLKITCLLTAVPFL*FLPKISRGYW
SSYSI*GKFAALYYQASGILPVKHICALHFISC
ELAGCPY*MLTHLSTLKGLQYQTRSWF*IP**K*
MFFL*KIIQMLK*DSTIVHCFLFFFLLRFSLIN
STFLHKIR*SWSKTRYSGMEIVKLNQKE*PVQH
TISET*KQVENNWLM*TKVPF**RQEKNSNI*VM
*G*KIH*LVFLHKRLV*I*LFTLRVFIRRFILG
IFPLDVLTD*SEL**AKGSECREH*AVMKKVW*
KARVVLYRQNQCQAFAVGLSELLI*I*K*IL*RH
CPFLLPHSLLYQHHSFITLIPGKSSLQCPRGRV
KPEIHAGLNNLFLFLFI*IFKFYGLLKN*INVV
SVFI*NKLPVDKIIKISLV

Frame 1

PARPRWRVKVVPPGKVELARRRPGALGPVGGCG
LRGPSWGTCLLLTKFGFG*NKNLACMYCFNSWK
NDR*QRCASRCVVWTNSNLFHAISG*DN*KGSRT
ILFAFAKSKLFDVGN*QSEKALSEGYETRRH**
DMV*I*RHTTEM
ALSNWFAI*SSCIKFSSSLEH
HSTF*EFSRKRPSALSI*GCN*SSFYVMYERS*C
FKT*KSSNQ*NAEKRSQATLDGIAK*QI*PVLG
HQSETHGISCRRKWISLYPL*NISDND*KTFHS
EAVSSCGCRWTVAHTRRSPQRSLSFCY*S*RWGK
KESSDDSWN*ANVGNTSAVAE*TSELPG*FSSY
*YHPTANRLKDQLFA*TESSLNGIYQSMSPFCF
NQVWWRQPDQKHFAAASQTGKRFHVR*GNWAGLT
LHHLCFPPLPSLNLSCDMKDLPDH*RSSVKYNE
AETFGLRRKWKYVPLDLYF*LTNKQGYFLR*PW
LNFSS*KWKHWFNFQEN*ESKREILLSITCK*FF
VKD*ITVNPSFLNENFLCLQSVYWYAIL*L***
TVRDF*IKPLNMFCHLITYSFVTFQVLSDSHTV
DHFLLCVTILTGRHWHGVDIGHRITCLRSCHRIS
CCQLKNLCSLHTTRINIVTVHLCCFITVSLSNH
SILSICKC*FCIFGKTHSFQASVFHWLQV*FFT
VVPGSQSFEV*RLPVS*LQYLFFNFYQKYPEVTG
VLIQYKESLLHFITKPLGFYQSNIFVHYISFLV
S*LAVHIEC*PI*VR*KAYSIRHDHGFRSHNKN
ECFSYKKLYKC*SEILLLFIASFSFSFCDFH*LI
AHFFTKLDKVGQRPDILEWKL*SLIKKNSQYSI
QSQKLRSK*KIIG*CKRKCHFSKGRKKIAIFEL
CKDKKSTDLYFCTRGWSEYDCSH*ECLFVGSFWG
FSPLMF*QIEVSFSEQKDQNAGNTKL**RKCGK
KPE*FYTDKTSVRPLQ*A*VNF*SRFESKFYED
IAHFYFLIHYCTSIIALLL*SQVSQAYNALEEE*
NQKFMLA*IIYFCFFSFEYLNFMVY*KIK*MLC
PSLFKTSYLLIKSLKFP*S

Frame 2

PPGRDGG*RWFLRARWSWRDAGPEPWGRLAGVA
CGVPLGVHVCCLLSLALVEIRI*PVCTALTPGR
MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAE
PYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDISE
IWFEYEGTPLKW
HYPIGLLFDLLASSSALPWNI
TVHFKSFPEKDLLHCPSKDAIEAHFMSCMKEAD
ALKHKSQVINEMQKKDHKQLWMGLQNDRFDQFWA
INRKLMEYPAEENGFRYIPFRIYQTTTERPFIQ
KLFRPVAADGQLHTLGDLLKEVCPSAIDPEDGE
KKNQVMIHGIEPMLETPLQWLSEHLSYPDNFLHI
SIIPQPTD*RINYLPEQNHP*MGFIRACHPFAS
IRFGGGNLTRNTSLLQARQEKDSMSDKATGLVL
LCITSAFLHCHH*TSAVT*KTYRTTEGLL*NIMK
LKPLA*EENGSMCHSICISD*QINRGIS*GDHG
*TLAHESGNIGLIFKRIKKVKEKFCYQ*LASNF
L*KIELQ*THLSLTKISYVYSLSIGMQSCNFDNE
Q*EIFK*SL*ICFVI**HTVLSLFKYFLTHIQ*
ITFYSVLPF*LVVIGMGWI*GIGLLVSEAVIEF
LAAN*KTCVLYTLHV*IL*LFIFVVLSL*ACQII
VS*ASVNANFAFLEKPIPSKLVFFIGSRSNFSL
WSLAASLLKFKDYLSLDCSTFSLIFTKNIQRLL
EFLFNIRKVCCTLLPSLWDFTSQTYLCITFHFL*
ASWLSILNVDPFEYAKRLTVSDTIMVLDPIIKM
NVFLIKNYTNAEVRFYYCSLLPFLFPFAIFTD*
*HISSQN*IKLVKDQIFWNGNCKA*SKRIASTAY
NLRNLEASRK*LVDVNESAILVKAGKK*QYLSY
VRIKNPLTCIFAQEAGLNMIVHIKSVYSSVHFG
DFPP*CFDRLK*ALVSKRIRMQGTLSCDEESVVK
SQSSFIQTKPVSGLCSRLE*TSDLDLKVNFMKT
LPIFTSSFIIVPAS*LYYSNPR*VKPTMP*RKS
KTRNSCWLK*SIFVSFHLNI*ILWFIKKLNKCCV
RLYLKQVTC**NH*NFLSH

Sequence APG5L.aAug05

GTGACGTCATCTCCGGGCGCCGAGGGTGACTGGACTTGTGGTGCGCTGCCAGGGCTCCGCAGCGTTGCCGGTTGTATTCGCTGGATACCAGAGGGCGGAA
GTGCAGCAGGGTTCAGCTCCGACCTCCGCGCCGGTGCTTTTTGCGGCTGCGCGGGCTTCCTGGAGTCCTGCTACCGCGTCCCCGCAGGACAGTGTGTCAG
GCGGGCAGCTTGCCCCGCCGCCCCACCGGAGCGCGGAATCTGGGCGTCCCCACCAGTGCGGGGAGCCGGAAGGAGGAGCCATAGCTTGGAGTAGGTTTGG
CTTTGGTTGAAATAAGAATTTAGCCTGTATGTACTGCTTTAACTCCTGGAAGAATGACAGATGACAAAGATGTGCTTCGAGATGTGTGGTTTGGACGAAT
TCCAACTTGTTTCACG
CTATATCAGGATGAGATAACTGAAAGGGAAGCAGAACCATACTATTTGCTTTTGCCAAGAGTAAGTTATTTGACGTTGGTAACT
GACAAAGTGAAAAAGCACTTTCAGAAGGTTATGAGACAAGAAGACATTAGTGAGATATGGTTTGAATATGAAGGCACACCACTGAAATG
GCATTATCCAA
TTGGTTTGCTATTTGATCTTCTTGCATCAAGTTCAGCTCTTCCTTGGAACATCACAGTACATTTTAAGAGTTTTCCAGAAAAAGACCTTCTGCACTGTCC
ATCTAAGGATGCAATTGAAGCTCATTTTATGTCATGTATGAAAGAAGCTGATGCTTTAAAACATAAAAGTCAAGTAATCAATGAAATGCAGAAAAAAGAT
CACAAGCAACTCTGGATGGGATTGCAAAATGACAGATTTGACCAGTTTTGGGCCATCAATCGGAAACTCATGGAATATCCTGCAGAAGAAAATGGATTTC
GTTATATCCCCTTTAGAATATATCAGACAACGACTGAAAGACCTTTCATTCAGAAGCTGTTTCGTCCTGTGGCTGCAGATGGACAGTTGCACACACTAGG
AGATCTCCTCAAAGAAGTTTGTCCTTCTGCTATTGATCCTGAAGATGGGGAAAAAAAGAATCAAGTGATGATTCATGGAATTGAGCCAATGTTGGAAACA
CCTCTGCAGTGGCTGAGTGAACATCTGAGCTACCCGGATAATTTTCTTCATATTAGTATCATCCCACAGCCAACAGATTGAAGGATCAACTATTTGCCTG
AACAGAATCATCCTTAAATGGGATTTATCAGAGCATGTCACCCTTTTGCTTCAATCAGGTTTGGTGGAGGCAACCTGACCAGAAACACTTCGCTGCTGCA
AGCCAGACAGGAAAAAGATTCCATGTCAGATAAGGCAACTGGGCTGGTCTTACTTTGCATCACCTCTGCTTTCCTCCACTGCCATCATTAAACCTCAGCT
GTGACATGAAAGACTTACCGGACCACTGAAGGTCTTCTGTAAAATATAATGAAGCTGAAACCTTTGGCCTAAGAAGAAAATGGAAGTATGTGCCACTCGA
TTTGTATTTCTGATTAACAAATAAACAGGGGTATTTCCTAAGGTGACCATGGTTGAACTTTAGCTCATGAAAGTGGAAACATTGGTTTAATTTTCAAGAG
AATTAAGAAAGTAAAAGAGAAATTCTGTTATCAATAACTTGCAAGTAATTTTTTGTAAAAGATTGAATTACAGTAAACCCATCTTTCCTTAACGAAAATT
TCCTATGTTTACAGTCTGTCTATTGGTATGCAATCTTGTAACTTTGATAATGAACAGTGAGAGATTTTTAAATAAAGCCTCTAAATATGTTTTGTCATTT
AATAACATACAGTTTTGTCACTTTTCAAGTACTTTCTGACTCACATACAGTAGATCACTTTTTACTCTGTGTTACCATTTTGACTGGTCGTCATTGGCAT
GGGGTGGATATAGGGCATAGGATTACTTGTCTCAGAAGCTGTCATAGAATTTCTTGCTGCCAATTAAAAAACCTGTGTTCTTTACACACTACACGTATAA
ATATTGTAACTGTTCATCTTTGTTGTTTTATCACTGTAAGCCTGTCAAATCATAGTATCCTAAGCATCTGTAAATGCTAATTTTGCATTTTTGGAAAAAC
CCATTCCTTCCAAGCTAGTGTTTTTCATTGGCTCCAGGTCTAATTTTTCACTGTGGTCCCTGGCAGCCAGTCTTTTGAAGTTTAAAGATTACCTGTCTCT
TGACTGCAGTACCTTTTCTTTAATTTTTACCAAAAATATCCAGAGGTTACTGGAGTTCTTATTCAATATAAGGAAAGTTTGCTGCACTTTATTACCAAGC
CTCTGGGATTTTACCAGTCAAACATATTTGTGCATTACATTTCATTTCTTGTGAGCTAGCTGGCTGTCCATATTGAATGTTGACCCATTTGAGTACGCTA
AAAGGCTTACAGTATCAGACACGATCATGGTTTTAGATCCCATAATAAAAATGAATGTTTTTCTTATAAAAAATTATACAAATGCTGAAGTGAGATTCTA
CTATTGTTCATTGCTTCCTTTTCTTTTTCCTTTTGCGATTTTCACTGATTAATAGCACATTTCTTCACAAAATTAGATAAAGTTGGTCAAAGACCAGATA
TTCTGGAATGGAAATTGTAAAGCTTAATCAAAAAGAATAGCCAGTACAGCATACAATCTCAGAAACTTAGAAGCAAGTAGAAAATAATTGGTTGATGTAA
ACGAAAGTGCCATTTTAGTAAAGGCAGGAAAAAAATAGCAATATTTGAGTTATGTAAGGATAAAAAATCCACTGACTTGTATTTTTGCACAAGAGGCTGG
TCTGAATATGATTGTTCACATTAAGAGTGTTTATTCGTCGGTTCATTTTGGGGATTTTCCCCCTTGATGTTTTGACAGATTGAAGTGAGCTTTAGTGAGC
AAAAGGATCAGAATGCAGGGAACACTAAGCTGTGATGAAGAAAGTGTGGTAAAAAGCCAGAGTAGTTTTATACAGACAAAACCAGTGTCAGGCCTTTGCA
GTAGGCTTGAGTGAACTTCTGATCTAGATTTGAAAGTAAATTTTATGAAGACATTGCCCATTTTTACTTCCTCATTCATTATTGTACCAGCATCATAGCT
TTATTACTCTAATCCCAGGTAAGTCAAGCCTACAATGCCCTAGAGGAAGAGTAAAACCAGAAATTCATGCTGGCTTAAATAATCTATTTTTGTTTCTTTT
CATTTGAATATTTAAATTTTATGGTTTATTAAAAAATTAAATAAATGTTGTGTCCGTCTTTATTTAAAACAAGTTACCTGTTGATAAAATCATTAAAATT
TCCTTAGTCAC
  • apg5l.f.1 (forward primer)
  • apg5l.r.4 (reverse primer)
  • Single exon skipping

Frame 0

VTSSPGAEGDWTCGALPGLRSVAGCIRWIPEGG
SAAGFSSDLRAGAFCGCAGFLESCYRVPAGQCVR
RAACPAAPPERGIWASPPVRGAGRRSHSLE*VW
LWLK*EFSLYVLL*LLEE*QMTKMCFEMCGLDE
FQLVSR
YIRMR*LKGKQNHTICFCQE*VI*RW*L
TK*KSTFRRL*DKKTLVRYGLNMKAHH*N
GIIQ
LVCYLIFLHQVQLFLGTSQYILRVFQKKTFCTV
HLRMQLKLILCHV*KKLML*NIKVK*SMKCRKKI
TSNSGWDCKMTDLTSFGPSIGNSWNILQKKMDF
VISPLEYIRQRLKDLSFRSCFVLWLQMDSCTH*
EISSKKFVLLLLILKMGKKRIK**FMELSQCWKH
LCSG*VNI*ATRIIFFILVSSHSQQIEGSTICL
NRIILKWDLSEHVTLLLQSGLVEAT*PETLRCC
KPDRKKIPCQIRQLGWSYFASPLLSSTAIIKPQL
*HERLTGPLKVFCKI**S*NLWPKKKMEVCATR
FVFLINK*TGVFPKVTMVEL*LMKVETLV*FSR
ELRK*KRNSVINNLQVIFCKRLNYSKPIFP*RKF
PMFTVCLLVCNLVTLIMNSERFLNKASKYVLSF
NNIQFCHFSSTF*LTYSRSLFTLCYHFDWSSLA
WGGYRA*DYLSQKLS*NFLLPIKKPVFFTHYTYK
YCNCSSLLFYHCKPVKS*YPKHL*MLILHFWKN
PFLPS*CFSLAPGLIFHCGPWQPVF*SLKITCL
LTAVPFL*FLPKISRGYWSSYSI*GKFAALYYQA
SGILPVKHICALHFISCELAGCPY*MLTHLSTL
KGLQYQTRSWF*IP**K*MFFL*KIIQMLK*DS
TIVHCFLFFFLLRFSLINSTFLHKIR*SWSKTRY
SGMEIVKLNQKE*PVQHTISET*KQVENNWLM*
TKVPF**RQEKNSNI*VM*G*KIH*LVFLHKRL
V*I*LFTLRVFIRRFILGIFPLDVLTD*SEL**A
KGSECREH*AVMKKVW*KARVVLYRQNQCQAFA
VGLSELLI*I*K*IL*RHCPFLLPHSLLYQHHS
FITLIPGKSSLQCPRGRVKPEIHAGLNNLFLFLF
I*IFKFYGLLKN*INVVSVFI*NKLPVDKIIKI
SLV

Frame 1

*RHLRAPRVTGLVVRCQGSAALPVVFAGYQRAE
VQQGSAPTSAPVLFAAARASWSPATASPQDSVS
GGQLAPPPHRSAESGRPHQCGEPEGGAIAWSRFG
FG*NKNLACMYCFNSWKNDR*QRCASRCVVWTN
SNLFH
AISG*DN*KGSRTILFAFAKSKLFDVGN
*QSEKALSEGYETRRH**DMV*I*RHTTEM
ALSN
WFAI*SSCIKFSSSLEHHSTF*EFSRKRPSALS
I*GCN*SSFYVMYERS*CFKT*KSSNQ*NAEKR
SQATLDGIAK*QI*PVLGHQSETHGISCRRKWIS
LYPL*NISDND*KTFHSEAVSSCGCRWTVAHTR
RSPQRSLSFCY*S*RWGKKESSDDSWN*ANVGN
TSAVAE*TSELPG*FSSY*YHPTANRLKDQLFA*
TESSLNGIYQSMSPFCFNQVWWRQPDQKHFAAA
SQTGKRFHVR*GNWAGLTLHHLCFPPLPSLNLS
CDMKDLPDH*RSSVKYNEAETFGLRRKWKYVPLD
LYF*LTNKQGYFLR*PWLNFSS*KWKHWFNFQE
N*ESKREILLSITCK*FFVKD*ITVNPSFLNEN
FLCLQSVYWYAIL*L***TVRDF*IKPLNMFCHL
ITYSFVTFQVLSDSHTVDHFLLCVTILTGRHWH
GVDIGHRITCLRSCHRISCCQLKNLCSLHTTRI
NIVTVHLCCFITVSLSNHSILSICKC*FCIFGKT
HSFQASVFHWLQV*FFTVVPGSQSFEV*RLPVS
*LQYLFFNFYQKYPEVTGVLIQYKESLLHFITK
PLGFYQSNIFVHYISFLVS*LAVHIEC*PI*VR*
KAYSIRHDHGFRSHNKNECFSYKKLYKC*SEIL
LLFIASFSFSFCDFH*LIAHFFTKLDKVGQRPD
ILEWKL*SLIKKNSQYSIQSQKLRSK*KIIG*CK
RKCHFSKGRKKIAIFELCKDKKSTDLYFCTRGW
SEYDCSH*ECLFVGSFWGFSPLMF*QIEVSFSE
QKDQNAGNTKL**RKCGKKPE*FYTDKTSVRPLQ
*A*VNF*SRFESKFYEDIAHFYFLIHYCTSIIA
LLL*SQVSQAYNALEEE*NQKFMLA*IIYFCFF
SFEYLNFMVY*KIK*MLCPSLFKTSYLLIKSLKF
P*S

Frame 2

DVISGRRG*LDLWCAARAPQRCRLYSLDTRGRK
CSRVQLRPPRRCFLRLRGLPGVLLPRPRRTVCQ
AGSLPRRPTGARNLGVPTSAGSRKEEP*LGVGL
ALVEIRI*PVCTALTPGRMTDDKDVLRDVWFGRI
PTCFT
LYQDEITEREAEPYYLLLPRVSYLTLVT
DKVKKHFQKVMRQEDISEIWFEYEGTPLKW
HYP
IGLLFDLLASSSALPWNITVHFKSFPEKDLLHCP
SKDAIEAHFMSCMKEADALKHKSQVINEMQKKD
HKQLWMGLQNDRFDQFWAINRKLMEYPAEENGF
RYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLG
DLLKEVCPSAIDPEDGEKKNQVMIHGIEPMLET
PLQWLSEHLSYPDNFLHISIIPQPTD*RINYLP
EQNHP*MGFIRACHPFASIRFGGGNLTRNTSLLQ
ARQEKDSMSDKATGLVLLCITSAFLHCHH*TSA
VT*KTYRTTEGLL*NIMKLKPLA*EENGSMCHS
ICISD*QINRGIS*GDHG*TLAHESGNIGLIFKR
IKKVKEKFCYQ*LASNFL*KIELQ*THLSLTKI
SYVYSLSIGMQSCNFDNEQ*EIFK*SL*ICFVI
**HTVLSLFKYFLTHIQ*ITFYSVLPF*LVVIGM
GWI*GIGLLVSEAVIEFLAAN*KTCVLYTLHV*
IL*LFIFVVLSL*ACQIIVS*ASVNANFAFLEK
PIPSKLVFFIGSRSNFSLWSLAASLLKFKDYLSL
DCSTFSLIFTKNIQRLLEFLFNIRKVCCTLLPS
LWDFTSQTYLCITFHFL*ASWLSILNVDPFEYA
KRLTVSDTIMVLDPIIKMNVFLIKNYTNAEVRFY
YCSLLPFLFPFAIFTD**HISSQN*IKLVKDQI
FWNGNCKA*SKRIASTAYNLRNLEASRK*LVDV
NESAILVKAGKK*QYLSYVRIKNPLTCIFAQEAG
LNMIVHIKSVYSSVHFGDFPP*CFDRLK*ALVS
KRIRMQGTLSCDEESVVKSQSSFIQTKPVSGLC
SRLE*TSDLDLKVNFMKTLPIFTSSFIIVPAS*L
YYSNPR*VKPTMP*RKSKTRNSCWLK*SIFVSF
HLNI*ILWFIKKLNKCCVRLYLKQVTC**NH*N
FLSH

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