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Sequences

Sequence AXL.cAug05

AGAGGGACAGCGCCCAGAGCCCGGATAGAGAGACACGGCCTCACTGGCTCAGGACAGGGGGCACAGCCACCAGGGTCCCCTTCCCCCTCCTCAGCTCCCT
CCCTGGCCCCTTTAAGAAAGAGCTGATCCTCTCCTCTCTTGAGTTAACCCCTGATTGTCCAGGTGGCCCCTGGGCTCTGGCCCTGGTGGGCGGAGGCAAA
GGGGGAGCCAGGGGCGGAGAAAGGGTTGCCCAAGTCTGGGAGTGAGGGAAGGAGGCAGGGGTGCTGAGAAGGCGGCTGCTGGGCAGAGCCGGTGGCAAGG
GCCTCCCCTGCCGCTGTGCCAGGCAGGCAGTGCCAAATCCGGGGAGCCTGGAGCTGGGGGGAGGGCCGGGGACAGCCCGGCCCTGCCCCCTCCCCCGCTG
GGAGCCCAACAACTTCTGAGGAAAGTTTGGCACCCATGGCGTGGCGGTGCCCCAGGATGGGCAGGGTCCCGCTGGCCTGGTGCTTGGCGCTGTGCGGCTG
GGCGTGCATGGCCCCCAGGGGCACGCAGGCTGAAGAAAGTCCCTTCGTGGGCAACCCAGGGAATATCACAGGTGCCCGGGGACTCACGGGCACCCTTCGG
TGTCAGCTCCAGGTTCAGGGAGAGCCCCCCGAGGTACATTGGCTTCGGGATGGACAGATCCTGGAGCTCGCGGACAGCACCCAGACCCAGGTGCCCCTGG
GTGAGGATGAACAGGATGACTGGATAGTGGTCAGCCAGCTCAGAATCACCTCCCTGCAGCTTTCCGACACGGGACAGTACCAGTGTTTGGTGTTTCTGGG
ACATCAGACCTTCGTGTCCCAGCCTGGCTATGTTGGGCTGGAGGGCTTGCCTTACTTCCTGGAGGAGCCCGAAGACAGGACTGTGGCCGCCAACACCCCC
TTCAACCTGAGCTGCCAAGCTCAGGGACCCCCAGAGCCCGTGGACCTACTCTGGCTCCAGGATGCTGTCCCCCTGGCCACGGCTCCAGGTCACGGCCCCC
AGCGCAGCCTGCATGTTCCAGGGCTGAACAAGACATCCTCTTTCTCCTGCGAAGCCCATAACGCCAAGGGGGTCACCACATCCCGCACAGCCACCATCAC
AGTGCTCCCCCAGCAGCCCCGTAACCTCCACCTGGTCTCCCGCCAACCCACGGAGCTGGAGGTGGCTTGGACTCCAGGCCTGAGCGGCATCTACCCCCTG
ACCCACTGCACCCTGCAGGCTGTGCTGTCAAACGATGGGATGGGCATCCAGGCGGGAGAACCAGACCCCCCAGAGGAGCCCCTCACCTCGCAAGCATCCG
TGCCCCCCCATCAGCTTCGGCTAGGCAGCCTCCATCCTCACACCCCTTATCACATCCGCGTGGCATGCACCAGCAGCCAGGGCCCCTCATCCTGGACCCA
CTGGCTTCCTGTGGAGACGCCGGAGGGAGTGCCCCTGGGCCCCCCTGAGAACATTAGTGCTACGCGGAATGGGAGCCAGGCCTTCGTGCATTGGCAAGAG
CCCCGGGCGCCCCTGCAGGGTACCCTGTTAGGGTACCGGCTGGCGTATCAAGGCCAGGACACCCCAGAGGTGCTAATGGACATAGGGCTAAGGCAAGAGG
TGACCCTGGAGCTGCAGGGGGACGGGTCTGTGTCCAATCTGACAGTGTGTGTGGCAGCCTACACTGCTGCTGGGGATGGACCCTGGAGCCTCCCAGTACC
CCTGGAGGCCTGGCGCCCAGTGAAGGAACCTTCAACTCCTGCCTTCTCGTGGCCCTGGTGGTATGTACTGCTAGGAGCAGTCGTGGCCGCTGCCTGTGTC
CTCATCTTGGCTCT
CTTCCTTGTCCACCGGCGAAAGAAGGAGACCCGTTATGGAGAAGTGTTTGAACCAACAGTGGAAAGAGGTGAACTGGTAGTCAGGT
ACCGCGTGCGCAAGTCCTACAGTCGTCGGACCACTGAAGCTACCTTGAACAGCCTGGGCATCAGTGAAGAGCTGAAGGAGAAGCTGCGGGATGTGATGGT
GGACCGGCACAAGGTGGCCCTGGGGAAGACTCTGGGAGAGGGAGAGTTTGGAGCTGTGATGGAAGGCCAGCTCAACCAGGACGACTCCATCCTCAAGGTG
GCTGTGAAGACGATGAAGATTGCCATCTGCACGAGGTCAGAGCTGGAGGATTTCCTGAGTGAAGCGGTCTGCATGAAGGAATTTGACCATCCCAACGTCA
TGAGGCTCATCGGTGTCTGTTTCCAGGGTTCTGAACGAGAGAGCTTCCCAGCACCTGTGGTCATCTTACCTTTCATGAAACATGGAGACCTACACAGCTT
CCTCCTCTATTCCCGGCTCGGGGACCAGCCAGTGTACCTGCCCACTCAGATGCTAGTGAAGTTCATGGCAGACATCGCCAGTGGCATGGAGTATCTGAGT
ACCAAGAGATTCATACACCGGGACCTGGCGGCCAGGAACTGCATGCTGAATGAGAACATGTCCGTGTGTGTGGCGGACTTCGGGCTCTCCAAGAAGATCT
ACAATGGGGACTACTACCGCCAGGGACGTATCGCCAAGATGCCAGTCAAGTGGATTGCCATTGAGAGTCTAGCTGACCGTGTCTACACCAGCAAGAGCGA
TGTGTGGTCCTTCGGGGTGACAATGTGGGAGATTGCCACAAGAGGCCAAACCCCATATCCGGGCGTGGAGAACAGCGAGATTTATGACTATCTGCGCCAG
GGAAATCGCCTGAAGCAGCCTGCGGACTGTCTGGATGGACTGTATGCCTTGATGTCGCGGTGCTGGGAGCTAAATCCCCAGGACCGGCCAAGTTTTACAG
AGCTGCGGGAAGATTTGGAGAACACACTGAAGGCCTTGCCTCCTGCCCAGGAGCCTGACGAAATCCTCTATGTCAACATGGATGAGGGTGGAGGTTATCC
TGAACCCCCTGGAGCTGCAGGAGGAGCTGACCCCCCAACCCAGCCAGACCCTAAGGATTCCTGTAGCTGCCTCACTGCGGCTGAGGTCCATCCTGCTGGA
CGCTATGTCCTCTGCCCTTCCACAACCCCTAGCCCCGCTCAGCCTGCTGATAGGGGCTCCCCAGCAGCCCCAGGGCAGGAGGATGGTGCCTGAGACAACC
CTCCACCTGGTACTCCCTCTCAGGATCCAAGCTAAGCACTGCCACTGGGGAAAACTCCACCTTCCCACTTTCCCACCCCACGCCTTATCCCCACTTGCAG
CCCTGTCTTCCTACCTATCCCACCTCCATCCCAGACAGGTCCCTCCCCTTCTCTGTGCAGTAGCATCACCTTGAAAGCAGTAGCATCACCATCTGTAAAA
GGAAGGGGTTGGATTGCAATATCTGAAGCCCTCCCAGGTGTTAACATTCCAAGACTCTAGAGTCCAAGGTTTAAAGAGTCTAGATTCAAAGGTTCTAGGT
TTCAAAGATGCTGTGAGTCTTTGGTTCTAAGGACCTGAAATTCCAAAGTCTCTAATTCTATTAAAGTGCTAAGGTTCTAAGGCCTACTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTGCGATAGAGTCTCACTGTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCGCCTCACTGCAACCTTCACCTACCGAGTTCA
AGTGATTTTCCTGCCTTGGCCTCCCAAGTAGCTGGGATTACAGGTGTGTGCCACCACACCCGGCTAATTTTTATATTTTTAGTAGAGACAGGGTTTCACC
ATGTTGGCCAGGCTGGTCTAAAACTCCTGACCTCAAGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCATGAGCCACTGCACTCAACC
TTAAGACCTACTGTTCTAAAGCTCTGACATTATGTGGTTTTAGATTTTCTGGTTCTAACATTTTTGATAAAGCCTCAAGGTTTTAGGTTCTAAAGTTCTA
AGATTCTGATTTTAGGAGCTAAGGCTCTATGAGTCTAGATGTTTATTCTTCTAGAGTTCAGAGTCCTTAAAATGTAAGATTATAGATTCTAAAGATTCTA
TAGTTCTAGACATGGAGGTTCTAAGGCCTAGGATTCTAAAATGTGATGTTCTAAGGCTCTGAGAGTCTAGATTCTCTGGCTGTAAGGCTCTAGATCATAA
GGCTTCAAAATGTTATCTTCTCAAGTTCTAAGATTCTAATGATGATCAATTATAGTTTCTGAGGCTTTATGATAATAGATTCTCTTGTATAAGATCCTAG
ATCCTAAGGGTCGAAAGCTCTAGAATCTGCAATTCAAAAGTTCCAAGAGTCTAAAGATGGAGTTTCTAAGGTCCGGTGTTCTAAGATGTGATATTCTAAG
ACTTACTCTAAGATCTTAGATTCTCTGTGTCTAAGATTCTAGATCAGATGCTCCAAGATTCTAGATGATTAAATAAGATTCTAACGGTCTGTTCTGTTTC
AAGGCACTCTAGATTCCATTGGTCCAAGATTCCGGATCCTAAGCATCTAAGTTATAAGACTCTCACACTCAGTTGTGACTAACTAGACACCAAAGTTCTA
ATAATTTCTAATGTTGGACACCTTTAGGTTCTTTGCTGCATTCTGCCTCTCTAGGACCATGGTTAAGAGTCCAAGAATCCACATTTCTAAAATCTTATAG
TTCTAGGCACTGTAGTTCTAAGACTCAAATGTTCTAAGTTTCTAAGATTCTAAAGGTCCACAGGTCTAGACTATTAGGTGCAATTTCAAGGTTCTAACCC
TATACTGTAGTATTCTTTGGGGTGCCCCTCTCCTTCTTAGCTATCATTGCTTCCTCCTCCCCAACTGTGGGGGTGTGCCCCCTTCAAGCCTGTGCAATGC
ATTAGGGATGCCTCCTTTCCCGCAGGGGATGGACGATCTCCCACCTTTCGGGCCATGTTGCCCCCGTGAGCCAATCCCTCACCTTCTGAGTACAGAGTGT
GGACTCTGGTGCCTCCAGAGGGGCTCAGGTCACATAAAACTTTGTATATCAACGAG
  • AXL_x151_x133_f (forward primer)
  • AXL_x151_x133_r (reverse primer)
  • Single exon skipping

Frame 0

RGTAPRARIERHGLTGSGQGAQPPGSPSPSSAP
SLAPLRKS*SSPLLS*PLIVQVAPGLWPWWAEAK
GEPGAEKGLPKSGSEGRRQGC*EGGCWAEPVAR
ASPAAVPGRQCQIRGAWSWGEGRGQPGPAPSPA
GSPTTSEESLAPMAWRCPRMGRVPLAWCLALCGW
ACMAPRGTQAEESPFVGNPGNITGARGLTGTLR
CQLQVQGEPPEVHWLRDGQILELADSTQTQVPL
GEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLG
HQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTP
FNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGP
QRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATIT
VLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPL
THCTLQAVLSNDGMGIQAGEPDPPEEPLTSQAS
VPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTH
WLPVETPEGVPLGPPENISATRNGSQAFVHWQE
PRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQE
VTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVP
LEAWRPVKEPSTPAFSWPWWYVLLGAVVAAACV
LILAL
FLVHRRKKETRYGEVFEPTVERGELVVR
YRVRKSYSRRTTEATLNSLGISEELKEKLRDVMV
DRHKVALGKTLGEGEFGAVMEGQLNQDDSILKV
AVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV
MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSF
LLYSRLGDQPVYLPTQMLVKFMADIASGMEYLS
TKRFIHRDLAARNCMLNENMSVCVADFGLSKKI
YNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSD
VWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQ
GNRLKQPADCLDGLYALMSRCWELNPQDRPSFT
ELREDLENTLKALPPAQEPDEILYVNMDEGGGYP
EPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAG
RYVLCPSTTPSPAQPADRGSPAAPGQEDGA*DN
PPPGTPSQDPS*ALPLGKTPPSHFPTPRLIPTCS
PVFLPIPPPSQTGPSPSLCSSITLKAVASPSVK
GRGWIAISEALPGVNIPRL*SPRFKESRFKGSR
FQRCCESLVLRT*NSKVSNSIKVLRF*GLLFFFF
FFFFFLR*SLTVSPRLECSGAISPHCNLHLPSS
SDFPALASQVAGITGVCHHTRLIFIFLVETGFH
HVGQAGLKLLTSSDLPTSASQSAEITGMSHCTQP
*DLLF*SSDIMWF*IFWF*HF**SLKVLGSKVL
RF*F*ELRLYESRCLFF*SSESLKCKIIDSKDS
IVLDMEVLRPRILKCDVLRL*ESRFSGCKALDHK
ASKCYLLKF*DSNDDQL*FLRLYDNRFSCIRS*
ILRVESSRICNSKVPRV*RWSF*GPVF*DVIF*
DLL*DLRFSVSKILDQMLQDSR*LNKILTVCSVS
RHSRFHWSKIPDPKHLSYKTLTLSCD*LDTKVL
IISNVGHL*VLCCILPL*DHG*ESKNPHF*NLI
VLGTVVLRLKCSKFLRF*RSTGLDY*VQFQGSNP
IL*YSLGCPSPS*LSLLPPPQLWGCAPFKPVQC
IRDASFPAGDGRSPTFRAMLPP*ANPSPSEYRV
WTLVPPEGLRSHKTLYINE

Frame 1

EGQRPEPG*RDTASLAQDRGHSHQGPLPPPQLP
PWPL*ERADPLLS*VNP*LSRWPLGSGPGGRRQ
RGSQGRRKGCPSLGVREGGRGAEKAAAGQSRWQG
PPLPLCQAGSAKSGEPGAGGRAGDSPALPPPPL
GAQQLLRKVWHPWRGGAPGWAGSRWPGAWRCAA
GRAWPPGARRLKKVPSWATQGISQVPGDSRAPFG
VSSRFRESPPRYIGFGMDRSWSSRTAPRPRCPW
VRMNRMTG*WSASSESPPCSFPTRDSTSVWCFW
DIRPSCPSLAMLGWRACLTSWRSPKTGLWPPTPP
ST*AAKLRDPQSPWTYSGSRMLSPWPRLQVTAP
SAACMFQG*TRHPLSPAKPITPRGSPHPAQPPS
QCSPSSPVTSTWSPANPRSWRWLGLQA*AASTP*
PTAPCRLCCQTMGWASRRENQTPQRSPSPRKHP
CPPISFG*AASILTPLITSAWHAPAARAPHPGP
TGFLWRRRRECPWAPLRTLVLRGMGARPSCIGKS
PGRPCRVPC*GTGWRIKARTPQRC*WT*G*GKR
*PWSCRGTGLCPI*QCVWQPTLLLGMDPGASQY
PWRPGAQ*RNLQLLPSRGPGGMYC*EQSWPLPVS
SSWL
SSLSTGERRRPVMEKCLNQQWKEVNW*SG
TACASPTVVGPLKLP*TAWASVKS*RRSCGM*W
WTGTRWPWGRLWERESLEL*WKASSTRTTPSSRW
L*RR*RLPSARGQSWRIS*VKRSA*RNLTIPTS
*GSSVSVSRVLNERASQHLWSSYLS*NMETYTA
SSSIPGSGTSQCTCPLRC**SSWQTSPVAWSI*V
PRDSYTGTWRPGTAC*MRTCPCVWRTSGSPRRS
TMGTTTARDVSPRCQSSGLPLRV*LTVSTPARA
MCGPSG*QCGRLPQEAKPHIRAWRTARFMTICAR
EIA*SSLRTVWMDCMP*CRGAGS*IPRTGQVLQ
SCGKIWRTH*RPCLLPRSLTKSSMSTWMRVEVI
LNPLELQEELTPQPSQTLRIPVAASLRLRSILLD
AMSSALPQPLAPLSLLIGAPQQPQGRRMVPETT
LHLVLPLRIQAKHCHWGKLHLPTFPPHALSPLA
ALSSYLSHLHPRQVPPLLCAVASP*KQ*HHHL*K
EGVGLQYLKPSQVLTFQDSRVQGLKSLDSKVLG
FKDAVSLWF*GPEIPKSLILLKC*GSKAYFFFF
FFFFFFCDRVSLCHPGWSAVVQSRLTATFTYRVQ
VIFLPWPPK*LGLQVCATTPG*FLYF**RQGFT
MLARLV*NS*PQVICPPQPPKVLRLQA*ATALN
LKTYCSKALTLCGFRFSGSNIFDKASRF*VLKF*
DSDFRS*GSMSLDVYSSRVQSP*NVRL*ILKIL
*F*TWRF*GLGF*NVMF*GSESLDSLAVRL*II
RLQNVIFSSSKILMMINYSF*GFMIIDSLV*DPR
S*GSKALESAIQKFQESKDGVSKVRCSKM*YSK
TYSKILDSLCLRF*IRCSKILDD*IRF*RSVLF
QGTLDSIGPRFRILSI*VIRLSHSVVTN*TPKF*
*FLMLDTFRFFAAFCLSRTMVKSPRIHISKIL*
F*AL*F*DSNVLSF*DSKGPQV*TIRCNFKVLT
LYCSILWGAPLLLSYHCFLLPNCGGVPPSSLCNA
LGMPPFPQGMDDLPPFGPCCPREPIPHLLSTEC
GLWCLQRGSGHIKLCIST

Frame 2

RDSAQSPDRETRPHWLRTGGTATRVPFPLLSSL
PGPFKKELILSSLELTPDCPGGPWALALVGGGK
GGARGGERVAQVWE*GKEAGVLRRRLLGRAGGK
GLPCRCARQAVPNPGSLELGGGPGTARPCPLPRW
EPNNF*GKFGTHGVAVPQDGQGPAGLVLGAVRL
GVHGPQGHAG*RKSLRGQPREYHRCPGTHGHPS
VSAPGSGRAPRGTLASGWTDPGARGQHPDPGAPG
*G*TG*LDSGQPAQNHLPAAFRHGTVPVFGVSG
TSDLRVPAWLCWAGGLALLPGGARRQDCGRQHP
LQPELPSSGTPRARGPTLAPGCCPPGHGSRSRPP
AQPACSRAEQDILFLLRSP*RQGGHHIPHSHHH
SAPPAAP*PPPGLPPTHGAGGGLDSRPERHLPP
DPLHPAGCAVKRWDGHPGGRTRPPRGAPHLASIR
APPSASARQPPSSHPLSHPRGMHQQPGPLILDP
LASCGDAGGSAPGPP*EH*CYAEWEPGLRALAR
APGAPAGYPVRVPAGVSRPGHPRGANGHRAKARG
DPGAAGGRVCVQSDSVCGSLHCCWGWTLEPPST
PGGLAPSEGTFNSCLLVALVVCTARSSRGRCLC
PHLGS
LPCPPAKEGDPLWRSV*TNSGKR*TGSQV
PRAQVLQSSDH*SYLEQPGHQ*RAEGEAAGCDG
GPAQGGPGEDSGRGRVWSCDGRPAQPGRLHPQG
GCEDDEDCHLHEVRAGGFPE*SGLHEGI*PSQRH
EAHRCLFPGF*TRELPSTCGHLTFHETWRPTQL
PPLFPARGPASVPAHSDASEVHGRHRQWHGVSE
YQEIHTPGPGGQELHAE*EHVRVCGGLRALQEDL
QWGLLPPGTYRQDASQVDCH*ESS*PCLHQQER
CVVLRGDNVGDCHKRPNPISGRGEQRDL*LSAP
GKSPEAACGLSGWTVCLDVAVLGAKSPGPAKFYR
AAGRFGEHTEGLASCPGA*RNPLCQHG*GWRLS
*TPWSCRRS*PPNPARP*GFL*LPHCG*GPSCW
TLCPLPFHNP*PRSAC**GLPSSPRAGGWCLRQP
STWYSLSGSKLSTATGENSTFPLSHPTPYPHLQ
PCLPTYPTSIPDRSLPFSVQ*HHLESSSITICK
RKGLDCNI*SPPRC*HSKTLESKV*RV*IQRF*V
SKML*VFGSKDLKFQSL*FY*SAKVLRPTFFFF
FFFFFFAIESHCVTQAGVQWCNLASLQPSPTEF
K*FSCLGLPSSWDYRCVPPHPANFYIFSRDRVSP
CWPGWSKTPDLK*SAHLSLPKC*DYRHEPLHST
LRPTVLKL*HYVVLDFLVLTFLIKPQGFRF*SS
KILILGAKAL*V*MFILLEFRVLKM*DYRF*RFY
SSRHGGSKA*DSKM*CSKALRV*ILWL*GSRS*
GFKMLSSQVLRF***SIIVSEAL***ILLYKIL
DPKGRKL*NLQFKSSKSLKMEFLRSGVLRCDILR
LTLRS*ILCV*DSRSDAPRF*MIK*DSNGLFCF
KAL*IPLVQDSGS*ASKL*DSHTQL*LTRHQSS
NNF*CWTPLGSLLHSASLGPWLRVQESTFLKSYS
SRHCSSKTQMF*VSKILKVHRSRLLGAISRF*P
YTVVFFGVPLSFLAIIASSSPTVGVCPLQACAM
H*GCLLSRRGWTISHLSGHVAPVSQSLTF*VQSV
DSGASRGAQVT*NFVYQR

Sequence AXL.bAug05

AGAGGGACAGCGCCCAGAGCCCGGATAGAGAGACACGGCCTCACTGGCTCAGGACAGGGGGCACAGCCACCAGGGTCCCCTTCCCCCTCCTCAGCTCCCT
CCCTGGCCCCTTTAAGAAAGAGCTGATCCTCTCCTCTCTTGAGTTAACCCCTGATTGTCCAGGTGGCCCCTGGGCTCTGGCCCTGGTGGGCGGAGGCAAA
GGGGGAGCCAGGGGCGGAGAAAGGGTTGCCCAAGTCTGGGAGTGAGGGAAGGAGGCAGGGGTGCTGAGAAGGCGGCTGCTGGGCAGAGCCGGTGGCAAGG
GCCTCCCCTGCCGCTGTGCCAGGCAGGCAGTGCCAAATCCGGGGAGCCTGGAGCTGGGGGGAGGGCCGGGGACAGCCCGGCCCTGCCCCCTCCCCCGCTG
GGAGCCCAACAACTTCTGAGGAAAGTTTGGCACCCATGGCGTGGCGGTGCCCCAGGATGGGCAGGGTCCCGCTGGCCTGGTGCTTGGCGCTGTGCGGCTG
GGCGTGCATGGCCCCCAGGGGCACGCAGGCTGAAGAAAGTCCCTTCGTGGGCAACCCAGGGAATATCACAGGTGCCCGGGGACTCACGGGCACCCTTCGG
TGTCAGCTCCAGGTTCAGGGAGAGCCCCCCGAGGTACATTGGCTTCGGGATGGACAGATCCTGGAGCTCGCGGACAGCACCCAGACCCAGGTGCCCCTGG
GTGAGGATGAACAGGATGACTGGATAGTGGTCAGCCAGCTCAGAATCACCTCCCTGCAGCTTTCCGACACGGGACAGTACCAGTGTTTGGTGTTTCTGGG
ACATCAGACCTTCGTGTCCCAGCCTGGCTATGTTGGGCTGGAGGGCTTGCCTTACTTCCTGGAGGAGCCCGAAGACAGGACTGTGGCCGCCAACACCCCC
TTCAACCTGAGCTGCCAAGCTCAGGGACCCCCAGAGCCCGTGGACCTACTCTGGCTCCAGGATGCTGTCCCCCTGGCCACGGCTCCAGGTCACGGCCCCC
AGCGCAGCCTGCATGTTCCAGGGCTGAACAAGACATCCTCTTTCTCCTGCGAAGCCCATAACGCCAAGGGGGTCACCACATCCCGCACAGCCACCATCAC
AGTGCTCCCCCAGCAGCCCCGTAACCTCCACCTGGTCTCCCGCCAACCCACGGAGCTGGAGGTGGCTTGGACTCCAGGCCTGAGCGGCATCTACCCCCTG
ACCCACTGCACCCTGCAGGCTGTGCTGTCAAACGATGGGATGGGCATCCAGGCGGGAGAACCAGACCCCCCAGAGGAGCCCCTCACCTCGCAAGCATCCG
TGCCCCCCCATCAGCTTCGGCTAGGCAGCCTCCATCCTCACACCCCTTATCACATCCGCGTGGCATGCACCAGCAGCCAGGGCCCCTCATCCTGGACCCA
CTGGCTTCCTGTGGAGACGCCGGAGGGAGTGCCCCTGGGCCCCCCTGAGAACATTAGTGCTACGCGGAATGGGAGCCAGGCCTTCGTGCATTGGCAAGAG
CCCCGGGCGCCCCTGCAGGGTACCCTGTTAGGGTACCGGCTGGCGTATCAAGGCCAGGACACCCCAGAGGTGCTAATGGACATAGGGCTAAGGCAAGAGG
TGACCCTGGAGCTGCAGGGGGACGGGTCTGTGTCCAATCTGACAGTGTGTGTGGCAGCCTACACTGCTGCTGGGGATGGACCCTGGAGCCTCCCAGTACC
CCTGGAGGCCTGGCGCCCAGGGCAAGCACAGCCAGTCCACCAGCTGGTGAAGGAACCTTCAACTCCTGCCTTCTCGTGGCCCTGGTGGTATGTACTGCTA
GGAGCAGTCGTGGCCGCTGCCTGTGTCCTCATCTTGGCTCTCTTCCTTGTCCACCGGCGAAAGAAGGAGACCCGTTATGGAGAAGTGTTTGAACCAACAG
TGGAAAGAGGTGAACTGGTAGTCAGGTACCGCGTGCGCAAGTCCTACAGTCGTCGGACCACTGAAGCTACCTTGAACAGCCTGGGCATCAGTGAAGAGCT
GAAGGAGAAGCTGCGGGATGTGATGGTGGACCGGCACAAGGTGGCCCTGGGGAAGACTCTGGGAGAGGGAGAGTTTGGAGCTGTGATGGAAGGCCAGCTC
AACCAGGACGACTCCATCCTCAAGGTGGCTGTGAAGACGATGAAGATTGCCATCTGCACGAGGTCAGAGCTGGAGGATTTCCTGAGTGAAGCGGTCTGCA
TGAAGGAATTTGACCATCCCAACGTCATGAGGCTCATCGGTGTCTGTTTCCAGGGTTCTGAACGAGAGAGCTTCCCAGCACCTGTGGTCATCTTACCTTT
CATGAAACATGGAGACCTACACAGCTTCCTCCTCTATTCCCGGCTCGGGGACCAGCCAGTGTACCTGCCCACTCAGATGCTAGTGAAGTTCATGGCAGAC
ATCGCCAGTGGCATGGAGTATCTGAGTACCAAGAGATTCATACACCGGGACCTGGCGGCCAGGAACTGCATGCTGAATGAGAACATGTCCGTGTGTGTGG
CGGACTTCGGGCTCTCCAAGAAGATCTACAATGGGGACTACTACCGCCAGGGACGTATCGCCAAGATGCCAGTCAAGTGGATTGCCATTGAGAGTCTAGC
TGACCGTGTCTACACCAGCAAGAGCGATGTGTGGTCCTTCGGGGTGACAATGTGGGAGATTGCCACAAGAGGCCAAACCCCATATCCGGGCGTGGAGAAC
AGCGAGATTTATGACTATCTGCGCCAGGGAAATCGCCTGAAGCAGCCTGCGGACTGTCTGGATGGACTGTATGCCTTGATGTCGCGGTGCTGGGAGCTAA
ATCCCCAGGACCGGCCAAGTTTTACAGAGCTGCGGGAAGATTTGGAGAACACACTGAAGGCCTTGCCTCCTGCCCAGGAGCCTGACGAAATCCTCTATGT
CAACATGGATGAGGGTGGAGGTTATCCTGAACCCCCTGGAGCTGCAGGAGGAGCTGACCCCCCAACCCAGCCAGACCCTAAGGATTCCTGTAGCTGCCTC
ACTGCGGCTGAGGTCCATCCTGCTGGACGCTATGTCCTCTGCCCTTCCACAACCCCTAGCCCCGCTCAGCCTGCTGATAGGGGCTCCCCAGCAGCCCCAG
GGCAGGAGGATGGTGCCTGAGACAACCCTCCACCTGGTACTCCCTCTCAGGATCCAAGCTAAGCACTGCCACTGGGGAAAACTCCACCTTCCCACTTTCC
CACCCCACGCCTTATCCCCACTTGCAGCCCTGTCTTCCTACCTATCCCACCTCCATCCCAGACAGGTCCCTCCCCTTCTCTGTGCAGTAGCATCACCTTG
AAAGCAGTAGCATCACCATCTGTAAAAGGAAGGGGTTGGATTGCAATATCTGAAGCCCTCCCAGGTGTTAACATTCCAAGACTCTAGAGTCCAAGGTTTA
AAGAGTCTAGATTCAAAGGTTCTAGGTTTCAAAGATGCTGTGAGTCTTTGGTTCTAAGGACCTGAAATTCCAAAGTCTCTAATTCTATTAAAGTGCTAAG
GTTCTAAGGCCTAGGATTCTAAAATGTGATGTTCTAAGGCTCTGAGAGTCTAGATTCTCTGGCTGTAAGGCTCTAGATCATAAGGCTTCAAAATGTTATC
TTCTCAAGTTCTAAGATTCTAATGATGATCAATTATAGTTTCTGAGGCTTTATGATAATAGATTCTCTTGTATAAGATCCTAGATCCTAAGGGTCGAAAG
CTCTAGAATCTGCAATTCAAAAGTTCCAAGAGTCTAAAGATGGAGTTTCTAAGGTCCGGTGTTCTAAGATGTGATATTCTAAGACTTACTCTAAGATCTT
AGATTCTCTGTGTCTAAGATTCTAGATCAGATGCTCCAAGATTCTAGATGATTAAATAAGATTCTAACGGTCTGTTCTGTTTCAAGGCACTCTAGATTCC
ATTGGTCCAAGATTCCGGATCCTAAGCATCTAAGTTATAAGACTCTCACACTCAGTTGTGACTAACTAGACACCAAAGTTCTAATAATTTCTAATGTTGG
ACACCTTTAGGTTCTTTGCTGCATTCTGCCTCTCTAGGACCATGGTTAAGAGTCCAAGAATCCACATTTCTAAAATCTTATAGTTCTAGGCACTGTAGTT
CTAAGACTCAAATGTTCTAAGTTTCTAAGATTCTAAAGGTCCACAGGTCTAGACTATTAGGTGCAATTTCAAGGTTCTAACCCTATACTGTAGTATTCTT
TGGGGTGCCCCTCTCCTTCTTAGCTATCATTGCTTCCTCCTCCCCAACTGTGGGGGTGTGCCCCCTTCAAGCCTGTGCAATGCATTAGGGATGCCTCCTT
TCCCGCAGGGGATGGACGATCTCCCACCTTTCGGGCCATGTTGCCCCCGTGAGCCAATCCCTCACCTTCTGAGTACAGAGTGTGGACTCTGGTGCCTCCA
GAGGGGCTCAGGTCACATAAAACTTTGTATATCAACGAG
  • AXL_x151_x133_f (forward primer)
  • AXL_x151_x133_r (reverse primer)
  • Single exon skipping

Frame 0

RGTAPRARIERHGLTGSGQGAQPPGSPSPSSAP
SLAPLRKS*SSPLLS*PLIVQVAPGLWPWWAEAK
GEPGAEKGLPKSGSEGRRQGC*EGGCWAEPVAR
ASPAAVPGRQCQIRGAWSWGEGRGQPGPAPSPA
GSPTTSEESLAPMAWRCPRMGRVPLAWCLALCGW
ACMAPRGTQAEESPFVGNPGNITGARGLTGTLR
CQLQVQGEPPEVHWLRDGQILELADSTQTQVPL
GEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLG
HQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTP
FNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGP
QRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATIT
VLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPL
THCTLQAVLSNDGMGIQAGEPDPPEEPLTSQAS
VPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTH
WLPVETPEGVPLGPPENISATRNGSQAFVHWQE
PRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQE
VTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVP
LEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLL
GAVVAAACVLILALFLVHRRKKETRYGEVFEPT
VERGELVVRYRVRKSYSRRTTEATLNSLGISEEL
KEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQL
NQDDSILKVAVKTMKIAICTRSELEDFLSEAVC
MKEFDHPNVMRLIGVCFQGSERESFPAPVVILPF
MKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMAD
IASGMEYLSTKRFIHRDLAARNCMLNENMSVCV
ADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLA
DRVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN
SEIYDYLRQGNRLKQPADCLDGLYALMSRCWEL
NPQDRPSFTELREDLENTLKALPPAQEPDEILYV
NMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCL
TAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAP
GQEDGA*DNPPPGTPSQDPS*ALPLGKTPPSHFP
TPRLIPTCSPVFLPIPPPSQTGPSPSLCSSITL
KAVASPSVKGRGWIAISEALPGVNIPRL*SPRF
KESRFKGSRFQRCCESLVLRT*NSKVSNSIKVLR
F*GLGF*NVMF*GSESLDSLAVRL*IIRLQNVI
FSSSKILMMINYSF*GFMIIDSLV*DPRS*GSK
ALESAIQKFQESKDGVSKVRCSKM*YSKTYSKIL
DSLCLRF*IRCSKILDD*IRF*RSVLFQGTLDS
IGPRFRILSI*VIRLSHSVVTN*TPKF**FLML
DTFRFFAAFCLSRTMVKSPRIHISKIL*F*AL*F
*DSNVLSF*DSKGPQV*TIRCNFKVLTLYCSIL
WGAPLLLSYHCFLLPNCGGVPPSSLCNALGMPP
FPQGMDDLPPFGPCCPREPIPHLLSTECGLWCLQ
RGSGHIKLCIST

Frame 1

EGQRPEPG*RDTASLAQDRGHSHQGPLPPPQLP
PWPL*ERADPLLS*VNP*LSRWPLGSGPGGRRQ
RGSQGRRKGCPSLGVREGGRGAEKAAAGQSRWQG
PPLPLCQAGSAKSGEPGAGGRAGDSPALPPPPL
GAQQLLRKVWHPWRGGAPGWAGSRWPGAWRCAA
GRAWPPGARRLKKVPSWATQGISQVPGDSRAPFG
VSSRFRESPPRYIGFGMDRSWSSRTAPRPRCPW
VRMNRMTG*WSASSESPPCSFPTRDSTSVWCFW
DIRPSCPSLAMLGWRACLTSWRSPKTGLWPPTPP
ST*AAKLRDPQSPWTYSGSRMLSPWPRLQVTAP
SAACMFQG*TRHPLSPAKPITPRGSPHPAQPPS
QCSPSSPVTSTWSPANPRSWRWLGLQA*AASTP*
PTAPCRLCCQTMGWASRRENQTPQRSPSPRKHP
CPPISFG*AASILTPLITSAWHAPAARAPHPGP
TGFLWRRRRECPWAPLRTLVLRGMGARPSCIGKS
PGRPCRVPC*GTGWRIKARTPQRC*WT*G*GKR
*PWSCRGTGLCPI*QCVWQPTLLLGMDPGASQY
PWRPGAQGKHSQSTSW*RNLQLLPSRGPGGMYC*
EQSWPLPVSSSWLSSLSTGERRRPVMEKCLNQQ
WKEVNW*SGTACASPTVVGPLKLP*TAWASVKS
*RRSCGM*WWTGTRWPWGRLWERESLEL*WKASS
TRTTPSSRWL*RR*RLPSARGQSWRIS*VKRSA
*RNLTIPTS*GSSVSVSRVLNERASQHLWSSYL
S*NMETYTASSSIPGSGTSQCTCPLRC**SSWQT
SPVAWSI*VPRDSYTGTWRPGTAC*MRTCPCVW
RTSGSPRRSTMGTTTARDVSPRCQSSGLPLRV*
LTVSTPARAMCGPSG*QCGRLPQEAKPHIRAWRT
ARFMTICAREIA*SSLRTVWMDCMP*CRGAGS*
IPRTGQVLQSCGKIWRTH*RPCLLPRSLTKSSM
STWMRVEVILNPLELQEELTPQPSQTLRIPVAAS
LRLRSILLDAMSSALPQPLAPLSLLIGAPQQPQ
GRRMVPETTLHLVLPLRIQAKHCHWGKLHLPTF
PPHALSPLAALSSYLSHLHPRQVPPLLCAVASP*
KQ*HHHL*KEGVGLQYLKPSQVLTFQDSRVQGL
KSLDSKVLGFKDAVSLWF*GPEIPKSLILLKC*
GSKA*DSKM*CSKALRV*ILWL*GSRS*GFKMLS
SQVLRF***SIIVSEAL***ILLYKILDPKGRK
L*NLQFKSSKSLKMEFLRSGVLRCDILRLTLRS
*ILCV*DSRSDAPRF*MIK*DSNGLFCFKAL*IP
LVQDSGS*ASKL*DSHTQL*LTRHQSSNNF*CW
TPLGSLLHSASLGPWLRVQESTFLKSYSSRHCS
SKTQMF*VSKILKVHRSRLLGAISRF*PYTVVFF
GVPLSFLAIIASSSPTVGVCPLQACAMH*GCLL
SRRGWTISHLSGHVAPVSQSLTF*VQSVDSGAS
RGAQVT*NFVYQR

Frame 2

RDSAQSPDRETRPHWLRTGGTATRVPFPLLSSL
PGPFKKELILSSLELTPDCPGGPWALALVGGGK
GGARGGERVAQVWE*GKEAGVLRRRLLGRAGGK
GLPCRCARQAVPNPGSLELGGGPGTARPCPLPRW
EPNNF*GKFGTHGVAVPQDGQGPAGLVLGAVRL
GVHGPQGHAG*RKSLRGQPREYHRCPGTHGHPS
VSAPGSGRAPRGTLASGWTDPGARGQHPDPGAPG
*G*TG*LDSGQPAQNHLPAAFRHGTVPVFGVSG
TSDLRVPAWLCWAGGLALLPGGARRQDCGRQHP
LQPELPSSGTPRARGPTLAPGCCPPGHGSRSRPP
AQPACSRAEQDILFLLRSP*RQGGHHIPHSHHH
SAPPAAP*PPPGLPPTHGAGGGLDSRPERHLPP
DPLHPAGCAVKRWDGHPGGRTRPPRGAPHLASIR
APPSASARQPPSSHPLSHPRGMHQQPGPLILDP
LASCGDAGGSAPGPP*EH*CYAEWEPGLRALAR
APGAPAGYPVRVPAGVSRPGHPRGANGHRAKARG
DPGAAGGRVCVQSDSVCGSLHCCWGWTLEPPST
PGGLAPRASTASPPAGEGTFNSCLLVALVVCTA
RSSRGRCLCPHLGSLPCPPAKEGDPLWRSV*TNS
GKR*TGSQVPRAQVLQSSDH*SYLEQPGHQ*RA
EGEAAGCDGGPAQGGPGEDSGRGRVWSCDGRPA
QPGRLHPQGGCEDDEDCHLHEVRAGGFPE*SGLH
EGI*PSQRHEAHRCLFPGF*TRELPSTCGHLTF
HETWRPTQLPPLFPARGPASVPAHSDASEVHGR
HRQWHGVSEYQEIHTPGPGGQELHAE*EHVRVCG
GLRALQEDLQWGLLPPGTYRQDASQVDCH*ESS
*PCLHQQERCVVLRGDNVGDCHKRPNPISGRGE
QRDL*LSAPGKSPEAACGLSGWTVCLDVAVLGAK
SPGPAKFYRAAGRFGEHTEGLASCPGA*RNPLC
QHG*GWRLS*TPWSCRRS*PPNPARP*GFL*LP
HCG*GPSCWTLCPLPFHNP*PRSAC**GLPSSPR
AGGWCLRQPSTWYSLSGSKLSTATGENSTFPLS
HPTPYPHLQPCLPTYPTSIPDRSLPFSVQ*HHL
ESSSITICKRKGLDCNI*SPPRC*HSKTLESKV*
RV*IQRF*VSKML*VFGSKDLKFQSL*FY*SAK
VLRPRILKCDVLRL*ESRFSGCKALDHKASKCY
LLKF*DSNDDQL*FLRLYDNRFSCIRS*ILRVES
SRICNSKVPRV*RWSF*GPVF*DVIF*DLL*DL
RFSVSKILDQMLQDSR*LNKILTVCSVSRHSRF
HWSKIPDPKHLSYKTLTLSCD*LDTKVLIISNVG
HL*VLCCILPL*DHG*ESKNPHF*NLIVLGTVV
LRLKCSKFLRF*RSTGLDY*VQFQGSNPIL*YS
LGCPSPS*LSLLPPPQLWGCAPFKPVQCIRDASF
PAGDGRSPTFRAMLPP*ANPSPSEYRVWTLVPP
EGLRSHKTLYINE

Sequence AXL.aAug05

AGAGGGACAGCGCCCAGAGCCCGGATAGAGAGACACGGCCTCACTGGCTCAGGACAGGGGGCACAGCCACCAGGGTCCCCTTCCCCCTCCTCAGCTCCCT
CCCTGGCCCCTTTAAGAAAGAGCTGATCCTCTCCTCTCTTGAGTTAACCCCTGATTGTCCAGGTGGCCCCTGGGCTCTGGCCCTGGTGGGCGGAGGCAAA
GGGGGAGCCAGGGGCGGAGAAAGGGTTGCCCAAGTCTGGGAGTGAGGGAAGGAGGCAGGGGTGCTGAGAAGGCGGCTGCTGGGCAGAGCCGGTGGCAAGG
GCCTCCCCTGCCGCTGTGCCAGGCAGGCAGTGCCAAATCCGGGGAGCCTGGAGCTGGGGGGAGGGCCGGGGACAGCCCGGCCCTGCCCCCTCCCCCGCTG
GGAGCCCAACAACTTCTGAGGAAAGTTTGGCACCCATGGCGTGGCGGTGCCCCAGGATGGGCAGGGTCCCGCTGGCCTGGTGCTTGGCGCTGTGCGGCTG
GGCGTGCATGGCCCCCAGGGGCACGCAGGCTGAAGAAAGTCCCTTCGTGGGCAACCCAGGGAATATCACAGGTGCCCGGGGACTCACGGGCACCCTTCGG
TGTCAGCTCCAGGTTCAGGGAGAGCCCCCCGAGGTACATTGGCTTCGGGATGGACAGATCCTGGAGCTCGCGGACAGCACCCAGACCCAGGTGCCCCTGG
GTGAGGATGAACAGGATGACTGGATAGTGGTCAGCCAGCTCAGAATCACCTCCCTGCAGCTTTCCGACACGGGACAGTACCAGTGTTTGGTGTTTCTGGG
ACATCAGACCTTCGTGTCCCAGCCTGGCTATGTTGGGCTGGAGGGCTTGCCTTACTTCCTGGAGGAGCCCGAAGACAGGACTGTGGCCGCCAACACCCCC
TTCAACCTGAGCTGCCAAGCTCAGGGACCCCCAGAGCCCGTGGACCTACTCTGGCTCCAGGATGCTGTCCCCCTGGCCACGGCTCCAGGTCACGGCCCCC
AGCGCAGCCTGCATGTTCCAGGGCTGAACAAGACATCCTCTTTCTCCTGCGAAGCCCATAACGCCAAGGGGGTCACCACATCCCGCACAGCCACCATCAC
AGTGCTCCCCCAGCAGCCCCGTAACCTCCACCTGGTCTCCCGCCAACCCACGGAGCTGGAGGTGGCTTGGACTCCAGGCCTGAGCGGCATCTACCCCCTG
ACCCACTGCACCCTGCAGGCTGTGCTGTCAAACGATGGGATGGGCATCCAGGCGGGAGAACCAGACCCCCCAGAGGAGCCCCTCACCTCGCAAGCATCCG
TGCCCCCCCATCAGCTTCGGCTAGGCAGCCTCCATCCTCACACCCCTTATCACATCCGCGTGGCATGCACCAGCAGCCAGGGCCCCTCATCCTGGACCCA
CTGGCTTCCTGTGGAGACGCCGGAGGGAGTGCCCCTGGGCCCCCCTGAGAACATTAGTGCTACGCGGAATGGGAGCCAGGCCTTCGTGCATTGGCAAGAG
CCCCGGGCGCCCCTGCAGGGTACCCTGTTAGGGTACCGGCTGGCGTATCAAGGCCAGGACACCCCAGAGGTGCTAATGGACATAGGGCTAAGGCAAGAGG
TGACCCTGGAGCTGCAGGGGGACGGGTCTGTGTCCAATCTGACAGTGTGTGTGGCAGCCTACACTGCTGCTGGGGATGGACCCTGGAGCCTCCCAGTACC
CCTGGAGGCCTGGCGCCCAGGGCAAGCACAGCCAGTCCACCAGCTGGTGAAGGAACCTTCAACTCCTGCCTTCTCGTGGCCCTGGTGGTATGTACTGCTA
GGAGCAGTCGTGGCCGCTGCCTGTGTCCTCATCTTGGCTCTCTTCCTTGTCCACCGGCGAAAGAAGGAGACCCGTTATGGAGAAGTGTTTGAACCAACAG
TGGAAAGAGGTGAACTGGTAGTCAGGTACCGCGTGCGCAAGTCCTACAGTCGTCGGACCACTGAAGCTACCTTGAACAGCCTGGGCATCAGTGAAGAGCT
GAAGGAGAAGCTGCGGGATGTGATGGTGGACCGGCACAAGGTGGCCCTGGGGAAGACTCTGGGAGAGGGAGAGTTTGGAGCTGTGATGGAAGGCCAGCTC
AACCAGGACGACTCCATCCTCAAGGTGGCTGTGAAGACGATGAAGATTGCCATCTGCACGAGGTCAGAGCTGGAGGATTTCCTGAGTGAAGCGGTCTGCA
TGAAGGAATTTGACCATCCCAACGTCATGAGGCTCATCGGTGTCTGTTTCCAGGGTTCTGAACGAGAGAGCTTCCCAGCACCTGTGGTCATCTTACCTTT
CATGAAACATGGAGACCTACACAGCTTCCTCCTCTATTCCCGGCTCGGGGACCAGCCAGTGTACCTGCCCACTCAGATGCTAGTGAAGTTCATGGCAGAC
ATCGCCAGTGGCATGGAGTATCTGAGTACCAAGAGATTCATACACCGGGACCTGGCGGCCAGGAACTGCATGCTGAATGAGAACATGTCCGTGTGTGTGG
CGGACTTCGGGCTCTCCAAGAAGATCTACAATGGGGACTACTACCGCCAGGGACGTATCGCCAAGATGCCAGTCAAGTGGATTGCCATTGAGAGTCTAGC
TGACCGTGTCTACACCAGCAAGAGCGATGTGTGGTCCTTCGGGGTGACAATGTGGGAGATTGCCACAAGAGGCCAAACCCCATATCCGGGCGTGGAGAAC
AGCGAGATTTATGACTATCTGCGCCAGGGAAATCGCCTGAAGCAGCCTGCGGACTGTCTGGATGGACTGTATGCCTTGATGTCGCGGTGCTGGGAGCTAA
ATCCCCAGGACCGGCCAAGTTTTACAGAGCTGCGGGAAGATTTGGAGAACACACTGAAGGCCTTGCCTCCTGCCCAGGAGCCTGACGAAATCCTCTATGT
CAACATGGATGAGGGTGGAGGTTATCCTGAACCCCCTGGAGCTGCAGGAGGAGCTGACCCCCCAACCCAGCCAGACCCTAAGGATTCCTGTAGCTGCCTC
ACTGCGGCTGAGGTCCATCCTGCTGGACGCTATGTCCTCTGCCCTTCCACAACCCCTAGCCCCGCTCAGCCTGCTGATAGGGGCTCCCCAGCAGCCCCAG
GGCAGGAGGATGGTGCCTGAGACAACCCTCCACCTGGTACTCCCTCTCAGGATCCAAGCTAAGCACTGCCACTGGGGAAAACTCCACCTTCCCACTTTCC
CACCCCACGCCTTATCCCCACTTGCAGCCCTGTCTTCCTACCTATCCCACCTCCATCCCAGACAGGTCCCTCCCCTTCTCTGTGCAGTAGCATCACCTTG
AAAGCAGTAGCATCACCATCTGTAAAAGGAAGGGGTTGGATTGCAATATCTGAAGCCCTCCCAGGTGTTAACATTCCAAGACTCTAGAGTCCAAGGTTTA
AAGAGTCTAGATTCAAAGGTTCTAGGTTTCAAAGATGCTGTGAGTCTTTGGTTCTAAGGACCTGAAATTCCAAAGTCTCTAATTCTATTAAAGTGCTAAG
GTTCTAAGGCCTACTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGCGATAGAGTCTCACTGTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCGCCT
CACTGCAACCTTCACCTACCGAGTTCAAGTGATTTTCCTGCCTTGGCCTCCCAAGTAGCTGGGATTACAGGTGTGTGCCACCACACCCGGCTAATTTTTA
TATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTAAAACTCCTGACCTCAAGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGAT
TACAGGCATGAGCCACTGCACTCAACCTTAAGACCTACTGTTCTAAAGCTCTGACATTATGTGGTTTTAGATTTTCTGGTTCTAACATTTTTGATAAAGC
CTCAAGGTTTTAGGTTCTAAAGTTCTAAGATTCTGATTTTAGGAGCTAAGGCTCTATGAGTCTAGATGTTTATTCTTCTAGAGTTCAGAGTCCTTAAAAT
GTAAGATTATAGATTCTAAAGATTCTATAGTTCTAGACATGGAGGTTCTAAGGCCTAGGATTCTAAAATGTGATGTTCTAAGGCTCTGAGAGTCTAGATT
CTCTGGCTGTAAGGCTCTAGATCATAAGGCTTCAAAATGTTATCTTCTCAAGTTCTAAGATTCTAATGATGATCAATTATAGTTTCTGAGGCTTTATGAT
AATAGATTCTCTTGTATAAGATCCTAGATCCTAAGGGTCGAAAGCTCTAGAATCTGCAATTCAAAAGTTCCAAGAGTCTAAAGATGGAGTTTCTAAGGTC
CGGTGTTCTAAGATGTGATATTCTAAGACTTACTCTAAGATCTTAGATTCTCTGTGTCTAAGATTCTAGATCAGATGCTCCAAGATTCTAGATGATTAAA
TAAGATTCTAACGGTCTGTTCTGTTTCAAGGCACTCTAGATTCCATTGGTCCAAGATTCCGGATCCTAAGCATCTAAGTTATAAGACTCTCACACTCAGT
TGTGACTAACTAGACACCAAAGTTCTAATAATTTCTAATGTTGGACACCTTTAGGTTCTTTGCTGCATTCTGCCTCTCTAGGACCATGGTTAAGAGTCCA
AGAATCCACATTTCTAAAATCTTATAGTTCTAGGCACTGTAGTTCTAAGACTCAAATGTTCTAAGTTTCTAAGATTCTAAAGGTCCACAGGTCTAGACTA
TTAGGTGCAATTTCAAGGTTCTAACCCTATACTGTAGTATTCTTTGGGGTGCCCCTCTCCTTCTTAGCTATCATTGCTTCCTCCTCCCCAACTGTGGGGG
TGTGCCCCCTTCAAGCCTGTGCAATGCATTAGGGATGCCTCCTTTCCCGCAGGGGATGGACGATCTCCCACCTTTCGGGCCATGTTGCCCCCGTGAGCCA
ATCCCTCACCTTCTGAGTACAGAGTGTGGACTCTGGTGCCTCCAGAGGGGCTCAGGTCACATAAAACTTTGTATATCAACGAG
  • AXL_x151_x133_f (forward primer)
  • AXL_x151_x133_r (reverse primer)
  • Single exon skipping

Frame 0

RGTAPRARIERHGLTGSGQGAQPPGSPSPSSAP
SLAPLRKS*SSPLLS*PLIVQVAPGLWPWWAEAK
GEPGAEKGLPKSGSEGRRQGC*EGGCWAEPVAR
ASPAAVPGRQCQIRGAWSWGEGRGQPGPAPSPA
GSPTTSEESLAPMAWRCPRMGRVPLAWCLALCGW
ACMAPRGTQAEESPFVGNPGNITGARGLTGTLR
CQLQVQGEPPEVHWLRDGQILELADSTQTQVPL
GEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLG
HQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTP
FNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGP
QRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATIT
VLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPL
THCTLQAVLSNDGMGIQAGEPDPPEEPLTSQAS
VPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTH
WLPVETPEGVPLGPPENISATRNGSQAFVHWQE
PRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQE
VTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVP
LEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLL
GAVVAAACVLILALFLVHRRKKETRYGEVFEPT
VERGELVVRYRVRKSYSRRTTEATLNSLGISEEL
KEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQL
NQDDSILKVAVKTMKIAICTRSELEDFLSEAVC
MKEFDHPNVMRLIGVCFQGSERESFPAPVVILPF
MKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMAD
IASGMEYLSTKRFIHRDLAARNCMLNENMSVCV
ADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLA
DRVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN
SEIYDYLRQGNRLKQPADCLDGLYALMSRCWEL
NPQDRPSFTELREDLENTLKALPPAQEPDEILYV
NMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCL
TAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAP
GQEDGA*DNPPPGTPSQDPS*ALPLGKTPPSHFP
TPRLIPTCSPVFLPIPPPSQTGPSPSLCSSITL
KAVASPSVKGRGWIAISEALPGVNIPRL*SPRF
KESRFKGSRFQRCCESLVLRT*NSKVSNSIKVLR
F*GLLFFFFFFFFFLR*SLTVSPRLECSGAISP
HCNLHLPSSSDFPALASQVAGITGVCHHTRLIF
IFLVETGFHHVGQAGLKLLTSSDLPTSASQSAEI
TGMSHCTQP*DLLF*SSDIMWF*IFWF*HF**S
LKVLGSKVLRF*F*ELRLYESRCLFF*SSESLK
CKIIDSKDSIVLDMEVLRPRILKCDVLRL*ESRF
SGCKALDHKASKCYLLKF*DSNDDQL*FLRLYD
NRFSCIRS*ILRVESSRICNSKVPRV*RWSF*G
PVF*DVIF*DLL*DLRFSVSKILDQMLQDSR*LN
KILTVCSVSRHSRFHWSKIPDPKHLSYKTLTLS
CD*LDTKVLIISNVGHL*VLCCILPL*DHG*ES
KNPHF*NLIVLGTVVLRLKCSKFLRF*RSTGLDY
*VQFQGSNPIL*YSLGCPSPS*LSLLPPPQLWG
CAPFKPVQCIRDASFPAGDGRSPTFRAMLPP*A
NPSPSEYRVWTLVPPEGLRSHKTLYINE

Frame 1

EGQRPEPG*RDTASLAQDRGHSHQGPLPPPQLP
PWPL*ERADPLLS*VNP*LSRWPLGSGPGGRRQ
RGSQGRRKGCPSLGVREGGRGAEKAAAGQSRWQG
PPLPLCQAGSAKSGEPGAGGRAGDSPALPPPPL
GAQQLLRKVWHPWRGGAPGWAGSRWPGAWRCAA
GRAWPPGARRLKKVPSWATQGISQVPGDSRAPFG
VSSRFRESPPRYIGFGMDRSWSSRTAPRPRCPW
VRMNRMTG*WSASSESPPCSFPTRDSTSVWCFW
DIRPSCPSLAMLGWRACLTSWRSPKTGLWPPTPP
ST*AAKLRDPQSPWTYSGSRMLSPWPRLQVTAP
SAACMFQG*TRHPLSPAKPITPRGSPHPAQPPS
QCSPSSPVTSTWSPANPRSWRWLGLQA*AASTP*
PTAPCRLCCQTMGWASRRENQTPQRSPSPRKHP
CPPISFG*AASILTPLITSAWHAPAARAPHPGP
TGFLWRRRRECPWAPLRTLVLRGMGARPSCIGKS
PGRPCRVPC*GTGWRIKARTPQRC*WT*G*GKR
*PWSCRGTGLCPI*QCVWQPTLLLGMDPGASQY
PWRPGAQGKHSQSTSW*RNLQLLPSRGPGGMYC*
EQSWPLPVSSSWLSSLSTGERRRPVMEKCLNQQ
WKEVNW*SGTACASPTVVGPLKLP*TAWASVKS
*RRSCGM*WWTGTRWPWGRLWERESLEL*WKASS
TRTTPSSRWL*RR*RLPSARGQSWRIS*VKRSA
*RNLTIPTS*GSSVSVSRVLNERASQHLWSSYL
S*NMETYTASSSIPGSGTSQCTCPLRC**SSWQT
SPVAWSI*VPRDSYTGTWRPGTAC*MRTCPCVW
RTSGSPRRSTMGTTTARDVSPRCQSSGLPLRV*
LTVSTPARAMCGPSG*QCGRLPQEAKPHIRAWRT
ARFMTICAREIA*SSLRTVWMDCMP*CRGAGS*
IPRTGQVLQSCGKIWRTH*RPCLLPRSLTKSSM
STWMRVEVILNPLELQEELTPQPSQTLRIPVAAS
LRLRSILLDAMSSALPQPLAPLSLLIGAPQQPQ
GRRMVPETTLHLVLPLRIQAKHCHWGKLHLPTF
PPHALSPLAALSSYLSHLHPRQVPPLLCAVASP*
KQ*HHHL*KEGVGLQYLKPSQVLTFQDSRVQGL
KSLDSKVLGFKDAVSLWF*GPEIPKSLILLKC*
GSKAYFFFFFFFFFFCDRVSLCHPGWSAVVQSRL
TATFTYRVQVIFLPWPPK*LGLQVCATTPG*FL
YF**RQGFTMLARLV*NS*PQVICPPQPPKVLR
LQA*ATALNLKTYCSKALTLCGFRFSGSNIFDKA
SRF*VLKF*DSDFRS*GSMSLDVYSSRVQSP*N
VRL*ILKIL*F*TWRF*GLGF*NVMF*GSESLD
SLAVRL*IIRLQNVIFSSSKILMMINYSF*GFMI
IDSLV*DPRS*GSKALESAIQKFQESKDGVSKV
RCSKM*YSKTYSKILDSLCLRF*IRCSKILDD*
IRF*RSVLFQGTLDSIGPRFRILSI*VIRLSHSV
VTN*TPKF**FLMLDTFRFFAAFCLSRTMVKSP
RIHISKIL*F*AL*F*DSNVLSF*DSKGPQV*T
IRCNFKVLTLYCSILWGAPLLLSYHCFLLPNCGG
VPPSSLCNALGMPPFPQGMDDLPPFGPCCPREP
IPHLLSTECGLWCLQRGSGHIKLCIST

Frame 2

RDSAQSPDRETRPHWLRTGGTATRVPFPLLSSL
PGPFKKELILSSLELTPDCPGGPWALALVGGGK
GGARGGERVAQVWE*GKEAGVLRRRLLGRAGGK
GLPCRCARQAVPNPGSLELGGGPGTARPCPLPRW
EPNNF*GKFGTHGVAVPQDGQGPAGLVLGAVRL
GVHGPQGHAG*RKSLRGQPREYHRCPGTHGHPS
VSAPGSGRAPRGTLASGWTDPGARGQHPDPGAPG
*G*TG*LDSGQPAQNHLPAAFRHGTVPVFGVSG
TSDLRVPAWLCWAGGLALLPGGARRQDCGRQHP
LQPELPSSGTPRARGPTLAPGCCPPGHGSRSRPP
AQPACSRAEQDILFLLRSP*RQGGHHIPHSHHH
SAPPAAP*PPPGLPPTHGAGGGLDSRPERHLPP
DPLHPAGCAVKRWDGHPGGRTRPPRGAPHLASIR
APPSASARQPPSSHPLSHPRGMHQQPGPLILDP
LASCGDAGGSAPGPP*EH*CYAEWEPGLRALAR
APGAPAGYPVRVPAGVSRPGHPRGANGHRAKARG
DPGAAGGRVCVQSDSVCGSLHCCWGWTLEPPST
PGGLAPRASTASPPAGEGTFNSCLLVALVVCTA
RSSRGRCLCPHLGSLPCPPAKEGDPLWRSV*TNS
GKR*TGSQVPRAQVLQSSDH*SYLEQPGHQ*RA
EGEAAGCDGGPAQGGPGEDSGRGRVWSCDGRPA
QPGRLHPQGGCEDDEDCHLHEVRAGGFPE*SGLH
EGI*PSQRHEAHRCLFPGF*TRELPSTCGHLTF
HETWRPTQLPPLFPARGPASVPAHSDASEVHGR
HRQWHGVSEYQEIHTPGPGGQELHAE*EHVRVCG
GLRALQEDLQWGLLPPGTYRQDASQVDCH*ESS
*PCLHQQERCVVLRGDNVGDCHKRPNPISGRGE
QRDL*LSAPGKSPEAACGLSGWTVCLDVAVLGAK
SPGPAKFYRAAGRFGEHTEGLASCPGA*RNPLC
QHG*GWRLS*TPWSCRRS*PPNPARP*GFL*LP
HCG*GPSCWTLCPLPFHNP*PRSAC**GLPSSPR
AGGWCLRQPSTWYSLSGSKLSTATGENSTFPLS
HPTPYPHLQPCLPTYPTSIPDRSLPFSVQ*HHL
ESSSITICKRKGLDCNI*SPPRC*HSKTLESKV*
RV*IQRF*VSKML*VFGSKDLKFQSL*FY*SAK
VLRPTFFFFFFFFFFAIESHCVTQAGVQWCNLA
SLQPSPTEFK*FSCLGLPSSWDYRCVPPHPANFY
IFSRDRVSPCWPGWSKTPDLK*SAHLSLPKC*D
YRHEPLHSTLRPTVLKL*HYVVLDFLVLTFLIK
PQGFRF*SSKILILGAKAL*V*MFILLEFRVLKM
*DYRF*RFYSSRHGGSKA*DSKM*CSKALRV*I
LWL*GSRS*GFKMLSSQVLRF***SIIVSEAL*
**ILLYKILDPKGRKL*NLQFKSSKSLKMEFLRS
GVLRCDILRLTLRS*ILCV*DSRSDAPRF*MIK
*DSNGLFCFKAL*IPLVQDSGS*ASKL*DSHTQ
L*LTRHQSSNNF*CWTPLGSLLHSASLGPWLRVQ
ESTFLKSYSSRHCSSKTQMF*VSKILKVHRSRL
LGAISRF*PYTVVFFGVPLSFLAIIASSSPTVG
VCPLQACAMH*GCLLSRRGWTISHLSGHVAPVSQ
SLTF*VQSVDSGASRGAQVT*NFVYQR

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