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Sequence TRAF3.aAug05
GGGAGCGCGGCGCGGCCGCCGCGTGCGCGAGCCGGGGTTGCAGCCCAGCCGGGACTTTCCAGCCGGCGGCAGCCGCGGCGGCCGCCGGCTCTTCCCCGCCCCCCGCCATGGGGCAGCCCGGGGAGCAGAACGCTGCGGACCGCGGCGGAGGACGCGCCCGGCGCCCCTGAGCCGGCCGAGCGGCGACGGACCGCGAGAAC
TCCTCTTTCCTAAAATGGAGTCGAGTAAAAAGATGGACTCTCCTGGCGCGCTGCAGACTAACCCGCCGCTAAAGCTGCACACTGACCGCAGTGCTGGGAC
GCCAGTTTTTGTCCCTGAACAAGGAGGTTACAAGGAAAAGTTTGTGAAGACCGTGGAGGACAAGTACAAGTGTGAGAAGTGCCACCTGGTGCTGTGCAGC
CCGAAGCAGACCGAGTGTGGGCACCGCTTCTGCGAGAGCTGCATGGCGGCCCTGCTGAGCTCTTCAAGTCCAAAATGTACAGCGTGTCAAGAGAGCATCG
TTAAAGATAAGGTGTTTAAGGATAATTGCTGCAAGAGAGAAATTCTGGCTCTTCAGATCTATTGTCGGAATGAAAGCAGAGGTTGTGCAGAGCAGTTAAT
GCTGGGACATCTGCTGGTGCATTTAAAAAATGATTGCCATTTTGAAGAACTTCCATGTGTGCGTCCTGACTGCAAAGAAAAGGTCTTGAGGAAAGACCTG
CGAGACCACGTGGAGAAGGCGTGTAAATACCGGGAAGCCACATGCAGCCACTGCAAGAGTCAGGTTCCGATGATCGCGCTGCAGAAACACGAAGACACCG
ACTGTCCCTGCGTGGTGGTGTCCTGCCCTCACAAGTGCAGCGTCCAGACTCTCCTGAGGAGCGAGTTGAGTGCACACTTGTCAGAGTGTGTCAATGCCCC
CAGCACCTGTAGTTTTAAGCGCTATGGCTGCGTTTTTCAGGGGACAAACCAGCAGATCAAGGCCCACGAGGCCAGCTCCGCCGTGCAGCACGTCAACCTG
CTGAAGGAGTGGAGCAACTCGCTCGAAAAGAAGGTTTCCTTGTTGCAGAATGAAAGTGTAGAAAAAAACAAGAGCATACAAAGTTTGCACAATCAGATAT
GTAGCTTTGAAATTGAAATTGAGAGACAAAAGGAAATGCTTCGAAATAATGAATCCAAAATCCTTCATTTACAGCGAGTGATAGACAGCCAAGCAGAGAA
ACTGAAGGAGCTTGACAAGGAGATCCGGCCCTTCCGGCAGAACTGGGAGGAAGCAGACAGCATGAAGAGCAGCGTGGAGTCCCTCCAGAACCGCGTGACC
GAGCTGGAGAGCGTGGACAAGAGCGCGGGGCAAGTGGCTCGGAACACAGGCCTGCTGGAGTCCCAGCTGAGCCGGCATGACCAGATGCTGAGTGTGCACG
ACATCCGCCTAGCCGACATGGACCTGCGCTTCCAGGTCCTGGAGACCGCCAGCTACAATGGAGTGCTCATCTGGAAGATTCGCGACTACAAGCGGCGGAA
GCAGGAGGCCGTCATGGGGAAGACCCTGTCCCTTTACAGCCAGCCTTTCTACACTGGTTACTTTGGCTATAAGATGTGTGCCAGGGTCTACCTGAACGGG
GACGGGATGGGGAAGGGGACGCACTTGTCGCTGTTTTTTGTCATCATGCGTGGAGAATATGATGCCCTGCTTCCTTGGCCGTTTAAGCAGAAAGTGACAC
TCATGCTGATGGATCAGGGGTCCTCTCGACGTCATTTGGGAGATGCATTCAAGCCCGACCCCAACAGCAGCAGCTTCAAGAAGCCCACTGGAGAGATGAA
TATCGCCTCTGGCTGCCCAGTCTTTGTGGCCCAAACTGTTCTAGAAAATGGGACATATATTAAAGATGATACAATTTTTATTAAAGTCATAGTGGATACT
TCGGATCTGCCCGATCCCTGATAAGTAGCTGGGGAGGTGGATTTAGCAGAAGGCAACTCCTCTGGGGGATTTGAACCGGTCTGTCTTCACTGAGGTCCTC
GCGCTCAGAAAAGGACCTTGTGAGACGGAGGAAGCGGCAGAAGGCGGACGCGTGCCGGCGGGAGGAGCCACGCGTGAGCACACCTGACACGTTTTATAAT
AGACTAGCCACACTTCACTCTGAAGAATTATTTATCCTTCAACAAGATAAATATTGCTGTCAGAGAAGGTTTTCATTTTCATTTTTAAAGATCTAGTTAA
TTAAGGTGGAAAACATATATGCTAAACAAAAGAAACATGATTTTTCTTCCTTAAACTTGAACACCAAAAAAACACACACACACACACACGTGGGGATAGC
TGGACATGTCAGCATGTTAAGTAAAAGGAGAATTTATGAAATAGTAATGCAATTCTGATATCTTCTTTCTAAAATTCAAGAGTGCAATTTTGTTTCAAAT
ACAGTATATTGTCTATTTTTAAGGCCTCATCTGGTCTCTGTTTTAATAATTTGTTTGTCAGAAGACCCTGAAGTATATACCTAGGTCTTTTTTTTGAAAG
TCTCTAAATTCAGAATCATTTTTTAATTTAAAGTTCTACAAATAATTGTTACTGCAAACATTTTATTTTAAAACGTTGATAGACTGATATTTCTTGGAAG
AAAATATAAAATATCAAACACTGGTTATCACTTGTGATAGGAAAGAGAATATTCAACCTGTTGTTATTTCTCGTTAGAAATGTAAACCTTCAAATATCTG
TCGTAGTTAATGACACGACTTCACAATTCTGAACGGAGCCTCGCTCATGGATGCTGTGCATCATTTTCAGATTTATAATTGTTTTCACCCTAAAATAGGG
CATCCGTTGAACTTTGGAGTTCTAAACAAAATCCTGTAGGTGTTTGGATTCTGCCCCATGTGTTCGGACGAGCTCTCTGTTGCTGACAGCACCGGCCTTC
GGTCTCCATGTCAGGGGTGGGCGGGTGACTGCTGAGGGAGGCCCGCAGGTGTGTTTCTCCATCCCGTCATCTTGCTGCATGCCGTCAACGGTCTCCGAAA
GCAACGTTGTGCGTAGAGCTGGTGGCATACGGCCCACGTGCCTTAGATGGGACATGCTGCTTCTCCACCCTGGGTTTGCATTGAGCATCATTCTAGAAAG
TGCTAGTTTAACCAGACTTTTCTCTCCACCACTAGATCTTTGTCTCTACAAGGGCCCTCAGACACCTCTGCACCTGCTGAGGGGAAGCCAGGCTCCACCG
TCGGCTTCTGGAGCCTCCGCTGCTTAATTACCACAGATTCCAAATCTCTAGGCCCCACGAGTGAGCCGCCTGGTCCAAGTACGGCCTGGTCCCACCCTGA
GGGAGGCAGGTGTGGAACAGAAGCCGAGCCTCTCCGTGTCCCCACCGGGGCCGTGGGCACCCCCACAGCCCGAAGCAGAACCCTCTGAGCATTCCAGAGA
CCGCTGCTCGGGGGCCTGCCCAGGCTGACCAACGGGCGCTCCTGACCACCACCCTGGCGGGAAGGGTGGCCACGGGGCCCGTCGTCCCAGCCTGTGCCTG
CCCAGATGGCATTTTCTCAACTCACTGTTTACTGTCTCTCAGTGTCCAACTGTGATTAGAAGCCTGGAGCCTGCCCCCTGCACCCCTTTTGCTATGCACC
ACGCTTCATGGTGCTCTTACCACTGATGGGTGCTACACGCGACGGGTGCTTCTTAGGCAAAACCAATGTGTGCGAACTGTCACACCTGTGCCACTCGCCC
ACAAGCCGCGCCCACAATTGGCCAGCTGGGCCGTGCACGTCAGACTGCCTGCCTCGGCTCTCCCCGTGGCCGCGCGGGGACAGCTTGGTGGGTGCCCGGT
GGCCCACCTGTCTCTGGTGCTGCCATCTGTCCTGGGTGTGCCTTCGCCCCAGTGCCTGCTGGAAGTGCCCTCCGTCGCACCCCTGTGCCCTGAGCTCCCG
TGAGGGGCCCGCCGCGCCCTTTCGCGGTCGAAGCGTTCCGTTGTTCTTATCTGCCTTTCCTTTCCCCGCTCTCCTGGGATTACTTTGGGGGAATGAGTAT
CCTTGGTTCTGCCCTGTGAGGGAGTCGTGTGTCCCTGCTCATAAAGGAAGGACTTCCTGCAGAAGCTGCGGAAAACTACTGTTCCCTCGAAGGTGTCCCC
CACCTGAGGCCTGTCCCCTACCTGCCCTCAGGTAGTTTTCCTGAGGCCAGGGGTTAACAACAGGGACATCCCTGCAACTTCCCCTTCACAAAATGTATAA
TATTAGATGAAGGATATGCAACATCTTGGTCTAGTAAGAACCGTTTCCTCCCCTCTGGGTTGAAGTCCTGGTGTGGCCCCCAGAAGCAGCAGTGCGTGTC
ACTGGGACGTCTCCAGTAGCCCTTCCCAGGCAGACGCTCCTGGCGGGACGCCATGGGGCCCACCTGAGGGTCCCACAGACGTAACCTGAGTGACAGGAGT
CCTTGAGGATGGGATGGCCTATGTCACACACTTTGTCCTTGAACCTGAGTGATGGGGGTCCTTGAGGATGGGATGGCCTGTGTCACGCGCTTTGTCTTTG
TGTTTGGTTGTATCGGGGTCTCTGTTCTGAGTGTGTCTTCCTCTCATGTACTCAACACAGTGGGCAGCAGCCTGGGACGGCGTCCCCTCTCCCGGCGGCG
GGCAAGCCTTGCGCTGCTCCACCCTCGGCCTGGGCACCCTCACTTGGCGCTGGCCACCTGGGCCAGCCTGGGGCCATGGTCTCTCTGCAGCTGAGGCCCA
GTGGCCCCTTGGGCAGTGATCGGCCCTCCCCGCATCACAGGGCCCTGGCAGCAAGCGGGAAATGGGGGCGCACACTGTGTGCTTGGGGGTGCTGCTTGTT
TACCACACATGACCAGACTCCCAGCAGGACAGAGCTGCTCAGTACTTTACAGAAACCAACTGAGTCGTTTGTGCATGAATTAAGCCGGTCTGCTTCCCCG
TCACCTTCGTAACAAAACAACGTCCCCTCTCCCCTCGCCTCGAGCAGTTTCTTCAGGACACCGTGGCTCGGGCTGCTCCCTGCTGCCAGGCACGCTGGTT
GGCTGGCCTGGGCCCGGCTCACGTGAAGGGCACTGGCTCTTGTGACCACACTGAGCCACGTGCAAGCCGCAGCCGGGCCTGGAAGCCTGACCCTCTGGTT
CTAGGGCTTGTCCCGCGGAGCCTGCAGAGCTAGACGTTGGGGTGTGTCCGTGATGATATGGGGGCCAGGCTGGGAGTAGGGCCTTTCTAGCAGGGTTGGG
TGGCTCAGTGAGGGTGTGGAAGTGGGGGACCCACGGGGCCTGGCTTTGGGACTAGACATGCCAGCCCCAGCTGGGCTGGAGGGAGCCTGAGTGAGCCCCG
ACATACGCTGGGCCTTTCAGCTCGCCGTGCTCTGGTGACACACAGGCGGCCAGGTTGGGATTTGTGTCAATTCTAGGAGCCATCAAGCATGAATGTGGTT
CTGTCTCCTGAGCGCAAGCCTCGCCGGACCCCTGGGCGAAGGCCTGGACTTGCAGATGTGTGTTCCCTGTGCGGGTGGACAGAGGGGGCCCTTATGACCC
ACATTGCAGCCCCATTCCACCACCCCTTCCTCCCCAGAGCAGTCTCTGCCGAGGGACAGCACCTGTGTCCCTTCGATGCCACAACAGCCAGTTGAACAGG
GGAGCCCTTTGCTCAGGCAGCTTCTCCTGCCTCTCCCTCCTTTCTCCTTCCCTGCCCCATCCCCGTGCCCTTCTTGGCCTGTGGCGCTGGGGAGCCATGG
TGTGGCATACTGGGGCTCCTGCTCCTTGGGCCACTTCCTCAGCCCGGGCCCCACAGGCCCACCACCTGCCAGGGCTCCCACTGCACTGGCTGTGGCAGGA
GGCTTCCCCATGACCCCGTGTGGCCCAGCTCGGTGAGGATGCAGTTCTAGGCACAGCCCCTGGGACAGCCAGCTGCCTCCCAGACCACGTCAGCCTGCTC
CAGGGTCCTCAGTCACCCTGGGCCAGGGGCCACGTGTCCCATGGATGTCGACCATGCCAACGTCACATTCCAGCACCCCTTTTGCTTGATGGCGTCTGGT
GGTAGTCAGCATGGTGGACCCACATCCTACAGCCAGAGGTGATGTTGGACAAAGGAAGGGGAGTCTGGATGGGTCCTTAAACGACCATTCTGTCCGCAGC
GGGGTCATTCCTTGTCAGCCCAAGGGAGGGCCGGGGAGTACACTGATCCCAACAGCTGGGCTGACACCTCCTTTCTCCCCTGCACGGGGAGGATTGGCCT
GAGGACCGTCACCCTGTGCACAGCCCCAGTAGGGTGGCAGTGCCACTGTCTCCTTGGGCCGTTGCAGGATTGGGCGGGTGCAGACTCCCCTTGCGGGCCC
CTTGCTCAATCCCCGGCCCTCCCAGACTCCTCCCTCTACTGGGGGTAATTTGTGTGTCAGAAGGGCTCTGGCAGAGCTGTAAAATACTGTTTTTTAAAAA
TTTTAGTCCAGATCTTTACTTATTAGACTGCAGAAGGAGAGCTAGGGAGAGTGGGGGAAGCCCCCTTGCTTTTGTATCTGTGAGGTGAATGAGGGTCTGT
CACCCAAATCTACTTCTCAGCCCATGACCATAGTTCTGTTTTCCGTTTGCAAATCTCAGTAGCTCTGTTTTCTCCAAAGTAGAATGTGCGCACCGGGGTC
CTAGCCAGGCGAGGTCAGTGTCGGCAGGCTACCTGGTCATTATTGCTGCCTCGTCCAGGCTGATGCTGATGGTCACAGGCACGGTGGCATCAGGGAGCCG
GGCCAGCAGGCGGCGTGAGGCGGGGCCAGCAGCTCACTGCAAGGGCATTTTCCACCTGATCCTGGTGTGCCCCACATGCGGTGGCAGGGCAGACGTGTGA
AGCCTCGGCCGTCTCGGGGCTGGCAGGTGTGCGGGTGAGGAGGCCCCGGTGGCCAAGCAGAGCCTGCGTTTCATTTCTCCTGCTGCACTGTGTCTAGTCT
GTCTTGTGAACTCTCACCGTGAAAAGAGGCTAGAAGTCCAGGATCGCTGTACCGCTCCTGTAATTAGGTGATGACTGGATTTGACAACTTAGTCCCCTCA
GACAAGTAAGATACCCTCCAACAGCAAATTCAATGACTTAATTGGAAAACACACAAGCTGGCATGATGTCCGGTGATTTCTGTAAGAAATGCCTGTAGGA
GAAGGTCTGTGAAGTGTGGAGGGCAGTGTCGACGCTGCACAGCATCTGCAGATTCGCAGCCTCTTCTCTGCCGGTGCCTCTGTTCGGTTCTGTTACCCAA
AAACAAAGACCAAAGAAGGCCAATCTCTCATTTGACCCTGTCTTTTTAATCTGCCTGTTTTAAAAGTTGCGTCTGTAGTAGCCGCTTGCTGTGAAGACAC
ATCTTGACAGTCCAAGTGATTTTGTGACCAGTGATTTGGGTCCTGTTTTCCGCTCTTCTAAGAAAAAACAAAAAGACCGTGAGTTATTGCCCAGCAATAA
TCATGTTGTTACTGTGAGTTAGCAACATGCCTGACTTCCTGATAGCATTACTGTTTTCTAGTTTTGTTTATTGTATATTATGTGTGGTTTTATTTGGTAT
TTATTTGTGTTTTGAGGTCTTGCAATGTTTTTGTGTTTCTGATGCTAATAACTAAAGTTTGTAAGACTGTAGAATGCAAAACTCGGAGATGCTAAACTGT
CTTATTAGAGGAAAATAAATCTGATTATGGAGTCTCA
- TRAF3.u.f.1 (forward primer)
- TRAF3.u.r.3 (reverse primer)
- Single exon skipping
Frame 0
GSAARPPRARAGVAAQPGLSSRRQPRRPPALPRPPPWGSPGSRTLRTAAEDAPGAPEPAERRRTART
PLS*NGVE*KDGLSWRAAD*PAAKAAH*PQCWD
ASFCP*TRRLQGKVCEDRGGQVQV*EVPPGAVQ
PEADRVWAPLLRELHGGPAELFKSKMYSVSREHR
*R*GV*G*LLQERNSGSSDLLSE*KQRLCRAVN
AGTSAGAFKK*LPF*RTSMCAS*LQRKGLEERP
ARPRGEGV*IPGSHMQPLQESGSDDRAAETRRHR
LSLRGGVLPSQVQRPDSPEERVECTLVRVCQCP
QHL*F*ALWLRFSGDKPADQGPRGQLRRAARQP
AEGVEQLARKEGFLVAE*KCRKKQEHTKFAQSDM
*L*N*N*ETKGNASK**IQNPSFTASDRQPSRE
TEGA*QGDPALPAELGGSRQHEEQRGVPPEPRD
RAGERGQERGASGSEHRPAGVPAEPA*PDAECAR
HPPSRHGPALPGPGDRQLQWSAHLEDSRLQAAE
AGGRHGEDPVPLQPAFLHWLLWL*DVCQGLPER
GRDGEGDALVAVFCHHAWRI*CPASLAV*AESDT
HADGSGVLSTSFGRCIQARPQQQQLQEAHWRDE
YRLWLPSLCGPNCSRKWDIY*R*YNFY*SHSGY
FGSARSLISSWGGGFSRRQLLWGI*TGLSSLRSS
RSEKDLVRRRKRQKADACRREEPRVSTPDTFYN
RLATLHSEELFILQQDKYCCQRRFSFSFLKI*L
IKVENIYAKQKKHDFSSLNLNTKKTHTHTHVGIA
GHVSMLSKRRIYEIVMQF*YLLSKIQECNFVSN
TVYCLFLRPHLVSVLIICLSEDPEVYT*VFFLK
VSKFRIIF*FKVLQIIVTANILF*NVDRLIFLGR
KYKISNTGYHL**EREYSTCCYFSLEM*TFKYL
S*LMTRLHNSERSLAHGCCASFSDL*LFSP*NR
ASVELWSSKQNPVGVWILPHVFGRALCC*QHRPS
VSMSGVGG*LLREARRCVSPSRHLAACRQRSPK
ATLCVELVAYGPRALDGTCCFSTLGLH*ASF*K
VLV*PDFSLHH*IFVSTRALRHLCTC*GEARLHR
RLLEPPLLNYHRFQISRPHE*AAWSKYGLVPP*
GRQVWNRSRASPCPHRGRGHPHSPKQNPLSIPE
TAARGPAQADQRALLTTTLAGRVATGPVVPACAC
PDGIFSTHCLLSLSVQL*LEAWSLPPAPLLLCT
TLHGALTTDGCYTRRVLLRQNQCVRTVTPVPLA
HKPRPQLASWAVHVRLPASALPVAARGQLGGCPV
AHLSLVLPSVLGVPSPQCLLEVPSVAPLCPELP
*GARRALSRSKRSVVLICLSFPRSPGITLGE*V
SLVLPCEGVVCPCS*RKDFLQKLRKTTVPSKVSP
T*GLSPTCPQVVFLRPGVNNRDIPATSPSQNV*
Y*MKDMQHLGLVRTVSSPLG*SPGVAPRSSSAC
HWDVSSSPSQADAPGGTPWGPPEGPTDVT*VTGV
LEDGMAYVTHFVLEPE*WGSLRMGWPVSRALSL
CLVVSGSLF*VCLPLMYSTQWAAAWDGVPSPGG
GQALRCSTLGLGTLTWRWPPGPAWGHGLSAAEAQ
WPLGQ*SALPASQGPGSKREMGAHTVCLGVLLV
YHT*PDSQQDRAAQYFTETN*VVCA*IKPVCFP
VTFVTKQRPLSPRLEQFLQDTVARAAPCCQARWL
AGLGPAHVKGTGSCDHTEPRASRSRAWKPDPLV
LGLVPRSLQS*TLGCVRDDMGARLGVGPF*QGW
VAQ*GCGSGGPTGPGFGTRHASPSWAGGSLSEPR
HTLGLSARRALVTHRRPGWDLCQF*EPSSMNVV
LSPERKPRRTPGRRPGLADVCSLCGWTEGALMT
HIAAPFHHPFLPRAVSAEGQHLCPFDATTAS*TG
EPFAQAASPASPSFLLPCPIPVPFLACGAGEPW
CGILGLLLLGPLPQPGPHRPTTCQGSHCTGCGR
RLPHDPVWPSSVRMQF*AQPLGQPAASQTTSACS
RVLSHPGPGATCPMDVDHANVTFQHPFCLMASG
GSQHGGPTSYSQR*CWTKEGESGWVLKRPFCPQ
RGHSLSAQGRAGEYTDPNSWADTSFLPCTGRIGL
RTVTLCTAPVGWQCHCLLGPLQDWAGADSPCGP
LAQSPALPDSSLYWG*FVCQKGSGRAVKYCFLK
ILVQIFTY*TAEGELGRVGEAPLLLYL*GE*GSV
TQIYFSAHDHSSVFRLQISVALFSPK*NVRTGV
LARRGQCRQATWSLLLPRPG*C*WSQARWHQGA
GPAGGVRRGQQLTARAFST*SWCAPHAVAGQTCE
ASAVSGLAGVRVRRPRWPSRACVSFLLLHCV*S
VL*TLTVKRG*KSRIAVPLL*LGDDWI*QLSPL
RQVRYPPTANSMT*LENTQAGMMSGDFCKKCL*E
KVCEVWRAVSTLHSICRFAASSLPVPLFGSVTQ
KQRPKKANLSFDPVFLICLF*KLRL**PLAVKT
HLDSPSDFVTSDLGPVFRSSKKKQKDRELLPSNN
HVVTVS*QHA*LPDSITVF*FCLLYIMCGFIWY
LFVF*GLAMFLCF*C**LKFVRL*NAKLGDAKL
SY*RKINLIMES
Frame 1
GARRGRRVREPGLQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRE
LLFPKMESSKKMDSPGALQTNPPLKLHTDRSAGT
PVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCS
PKQTECGHRFCESCMAALLSSSSPKCTACQESI
VKDKVFKDNCCKREILALQIYCRNESRGCAEQLM
LGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDL
RDHVEKACKYREATCSHCKSQVPMIALQKHEDT
DCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAP
STCSFKRYGCVFQGTNQQIKAHEASSAVQHVNL
LKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQI
CSFEIEIERQKEMLRNNESKILHLQRVIDSQAEK
LKELDKEIRPFRQNWEEADSMKSSVESLQNRVT
ELESVDKSAGQVARNTGLLESQLSRHDQMLSVH
DIRLADMDLRFQVLETASYNGVLIWKIRDYKRRK
QEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNG
DGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVT
LMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMN
IASGCPVFVAQTVLENGTYIKDDTIFIKVIVDT
SDLPDP**VAGEVDLAEGNSSGGFEPVCLH*GP
RAQKRTL*DGGSGRRRTRAGGRSHA*AHLTRFII
D*PHFTLKNYLSFNKINIAVREGFHFHF*RSS*
LRWKTYMLNKRNMIFLP*T*TPKKHTHTHTWG*
LDMSAC*VKGEFMK**CNSDIFFLKFKSAILFQI
QYIVYF*GLIWSLF**FVCQKTLKYIPRSFF*K
SLNSESFFNLKFYK*LLLQTFYFKTLID*YFLE
ENIKYQTLVITCDRKENIQPVVISR*KCKPSNIC
RS**HDFTILNGASLMDAVHHFQIYNCFHPKIG
HPLNFGVLNKIL*VFGFCPMCSDELSVADSTGL
RSPCQGWAGDC*GRPAGVFLHPVILLHAVNGLRK
QRCA*SWWHTAHVP*MGHAASPPWVCIEHHSRK
C*FNQTFLSTTRSLSLQGPSDTSAPAEGKPGST
VGFWSLRCLITTDSKSLGPTSEPPGPSTAWSHPE
GGRCGTEAEPLRVPTGAVGTPTARSRTL*AFQR
PLLGGLPRLTNGRS*PPPWREGWPRGPSSQPVP
AQMAFSQLTVYCLSVSNCD*KPGACPLHPFCYAP
RFMVLLPLMGATRDGCFLGKTNVCELSHLCHSP
TSRAHNWPAGPCTSDCLPRLSPWPRGDSLVGAR
WPTCLWCCHLSWVCLRPSACWKCPPSHPCALSSR
EGPAAPFRGRSVPLFLSAFPFPALLGLLWGNEY
PWFCPVRESCVPAHKGRTSCRSCGKLLFPRRCP
PPEACPLPALR*FS*GQGLTTGTSLQLPLHKMYN
IR*RICNILV**EPFPPLWVEVLVWPPEAAVRV
TGTSPVALPRQTLLAGRHGAHLRVPQT*PE*QE
SLRMGWPMSHTLSLNLSDGGP*GWDGLCHALCLC
VWLYRGLCSECVFLSCTQHSGQQPGTASPLPAA
GKPCAAPPSAWAPSLGAGHLGQPGAMVSLQLRP
SGPLGSDRPSPHHRALAASGKWGRTLCAWGCCLF
TTHDQTPSRTELLSTLQKPTESFVHELSRSASP
SPS*QNNVPSPLASSSFFRTPWLGLLPAARHAG
WLAWARLT*RALALVTTLSHVQAAAGPGSLTLWF
*GLSRGACRARRWGVSVMIWGPGWE*GLSSRVG
WLSEGVEVGDPRGLALGLDMPAPAGLEGA*VSP
DIRWAFQLAVLW*HTGGQVGICVNSRSHQA*MWF
CLLSASLAGPLGEGLDLQMCVPCAGGQRGPL*P
TLQPHSTTPSSPEQSLPRDSTCVPSMPQQPVEQ
GSPLLRQLLLPLPPFSFPAPSPCPSWPVALGSHG
VAYWGSCSLGHFLSPGPTGPPPARAPTALAVAG
GFPMTPCGPAR*GCSSRHSPWDSQLPPRPRQPA
PGSSVTLGQGPRVPWMSTMPTSHSSTPFA*WRLV
VVSMVDPHPTARGDVGQRKGSLDGSLNDHSVRS
GVIPCQPKGGPGSTLIPTAGLTPPFSPARGGLA
*GPSPCAQPQ*GGSATVSLGRCRIGRVQTPLAGP
LLNPRPSQTPPSTGGNLCVRRALAEL*NTVF*K
F*SRSLLIRLQKES*GEWGKPPCFCICEVNEGL
SPKSTSQPMTIVLFSVCKSQ*LCFLQSRMCAPGS
*PGEVSVGRLPGHYCCLVQADADGHRHGGIREP
GQQAA*GGASSSLQGHFPPDPGVPHMRWQGRRV
KPRPSRGWQVCG*GGPGGQAEPAFHFSCCTVSSL
SCELSP*KEARSPGSLYRSCN*VMTGFDNLVPS
DK*DTLQQQIQ*LNWKTHKLA*CPVISVRNACR
RRSVKCGGQCRRCTASADSQPLLCRCLCSVLLPK
NKDQRRPISHLTLSF*SACFKSCVCSSRLL*RH
ILTVQVIL*PVIWVLFSALLRKNKKTVSYCPAI
IMLLL*VSNMPDFLIALLFSSFVYCILCVVLFGI
YLCFEVLQCFCVSDANN*SL*DCRMQNSEMLNC
LIRGK*I*LWSL
Frame 2
ERGAAAACASRGCSPAGTFQPAAAAAAAGSSPPPAMGQPGEQNAADRGGGRARRP*AGRAATDREN
SSFLKWSRVKRWTLLARCRLTRR*SCTLTAVLG
RQFLSLNKEVTRKSL*RPWRTSTSVRSATWCCAA
RSRPSVGTASARAAWRPC*ALQVQNVQRVKRAS
LKIRCLRIIAAREKFWLFRSIVGMKAEVVQSS*
CWDICWCI*KMIAILKNFHVCVLTAKKRS*GKTC
ETTWRRRVNTGKPHAATARVRFR*SRCRNTKTP
TVPAWWCPALTSAASRLS*GAS*VHTCQSVSMP
PAPVVLSAMAAFFRGQTSRSRPTRPAPPCSTSTC
*RSGATRSKRRFPCCRMKV*KKTRAYKVCTIRY
VALKLKLRDKRKCFEIMNPKSFIYSE**TAKQR
N*RSLTRRSGPSGRTGRKQTA*RAAWSPSRTA*P
SWRAWTRARGKWLGTQACWSPS*AGMTRC*VCT
TSA*PTWTCASRSWRPPATMECSSGRFATTSGG
SRRPSWGRPCPFTASLSTLVTLAIRCVPGST*TG
TGWGRGRTCRCFLSSCVENMMPCFLGRLSRK*H
SC*WIRGPLDVIWEMHSSPTPTAAASRSPLER*
ISPLAAQSLWPKLF*KMGHILKMIQFLLKS*WIL
RICPIPDK*LGRWI*QKATPLGDLNRSVFTEVL
ALRKGPCETEEAAEGGRVPAGGATREHT*HVL*
*TSHTSL*RIIYPSTR*ILLSEKVFIFIFKDLVN
*GGKHIC*TKET*FFFLKLEHQKNTHTHTRGDS
WTCQHVK*KENL*NSNAILISSF*NSRVQFCFK
YSILSIFKASSGLCFNNLFVRRP*SIYLGLFFES
L*IQNHFLI*SSTNNCYCKHFILKR**TDISWK
KI*NIKHWLSLVIGKRIFNLLLFLVRNVNLQIS
VVVNDTTSQF*TEPRSWMLCIIFRFIIVFTLK*G
IR*TLEF*TKSCRCLDSAPCVRTSSLLLTAPAF
GLHVRGGRVTAEGGPQVCFSIPSSCCMPSTVSE
SNVVRRAGGIRPTCLRWDMLLLHPGFALSIILES
ASLTRLFSPPLDLCLYKGPQTPLHLLRGSQAPP
SASGASAA*LPQIPNL*APRVSRLVQVRPGPTL
REAGVEQKPSLSVSPPGPWAPPQPEAEPSEHSRD
RCSGACPG*PTGAPDHHPGGKGGHGARRPSLCL
PRWHFLNSLFTVSQCPTVIRSLEPAPCTPFAMH
HASWCSYH*WVLHATGAS*AKPMCANCHTCATRP
QAAPTIGQLGRARQTACLGSPRGRAGTAWWVPG
GPPVSGAAICPGCAFAPVPAGSALRRTPVP*AP
VRGPPRPFAVEAFRCSYLPFLSPLSWDYFGGMSI
LGSAL*GSRVSLLIKEGLPAEAAENYCSLEGVP
HLRPVPYLPSGSFPEARG*QQGHPCNFPFTKCI
ILDEGYATSWSSKNRFLPSGLKSWCGPQKQQCVS
LGRLQ*PFPGRRSWRDAMGPT*GSHRRNLSDRS
P*GWDGLCHTLCP*T*VMGVLEDGMACVTRFVF
VFGCIGVSVLSVSSSHVLNTVGSSLGRRPLSRRR
ASLALLHPRPGHPHLALATWASLGPWSLCS*GP
VAPWAVIGPPRITGPWQQAGNGGAHCVLGGAAC
LPHMTRLPAGQSCSVLYRNQLSRLCMN*AGLLPR
HLRNKTTSPLPSPRAVSSGHRGSGCSLLPGTLV
GWPGPGSREGHWLL*PH*ATCKPQPGLEA*PSG
SRACPAEPAELDVGVCP**YGGQAGSRAFLAGLG
GSVRVWKWGTHGAWLWD*TCQPQLGWREPE*AP
TYAGPFSSPCSGDTQAARLGFVSILGAIKHECG
SVS*AQASPDPWAKAWTCRCVFPVRVDRGGPYDP
HCSPIPPPLPPQSSLCRGTAPVSLRCHNSQLNR
GALCSGSFSCLSLLSPSLPHPRALLGLWRWGAM
VWHTGAPAPWATSSARAPQAHHLPGLPLHWLWQE
ASP*PRVAQLGEDAVLGTAPGTASCLPDHVSLL
QGPQSPWARGHVSHGCRPCQRHIPAPLLLDGVW
W*SAWWTHILQPEVMLDKGRGVWMGP*TTILSAA
GSFLVSPREGRGVH*SQQLG*HLLSPLHGEDWP
EDRHPVHSPSRVAVPLSPWAVAGLGGCRLPLRA
PCSIPGPPRLLPLLGVICVSEGLWQSCKILFFKN
FSPDLYLLDCRRRARESGGSPLAFVSVR*MRVC
HPNLLLSP*P*FCFPFANLSSSVFSKVECAHRG
PSQARSVSAGYLVIIAASSRLMLMVTGTVASGSR
ASRRREAGPAAHCKGIFHLILVCPTCGGRADV*
SLGRLGAGRCAGEEAPVAKQSLRFISPAALCLV
CLVNSHREKRLEVQDRCTAPVIR**LDLTT*SPQ
TSKIPSNSKFNDLIGKHTSWHDVR*FL*EMPVG
EGL*SVEGSVDAAQHLQIRSLFSAGASVRFCYP
KTKTKEGQSLI*PCLFNLPVLKVASVVAACCEDT
S*QSK*FCDQ*FGSCFPLF*EKTKRP*VIAQQ*
SCCYCELATCLTS**HYCFLVLFIVYYVWFYLV
FICVLRSCNVFVFLMLITKVCKTVECKTRRC*TV
LLEENKSDYGVS
Sequence TRAF3.cAug05
GGGAGCGCGGCGCGGCCGCCGCGTGCGCGAGCCGGGGTTGCAGCCCAGCCGGGACTTTCCAGCCGGCGGCAGCCGCGGCGGCCGCCGGCTCTTCCCCGCCCCCCGCCATGGGGCAGCCCGGGGAGCAGAACGCTGCGGACCGCGGCGGAGGACGCGCCCGGCGCCCCTGAGCCGGCCGAGCGGCGACGGACCGCGAGATG
AGGAAAATGAGGCCCAAAGAAGTGATGCCACTTGGTTAAGGTCCCAGAGCAGGTCAGAATCAGACCTAGGATCAGAAACCTGGCTCCTGGCTCCTGGCTC
CCTACTCTTCTAAGGATCGCTGTCCTGACAGAAGAGAACTCCTCTTTCCTAAAATGGAGTCGAGTAAAAAGATGGACTCTCCTGGCGCGCTGCAGACTAA
CCCGCCGCTAAAGCTGCACACTGACCGCAGTGCTGGGACGCCAGTTTTTGTCCCTGAACAAGGAGGTTACAAGGAAAAGTTTGTGAAGACCGTGGAGGAC
AAGTACAAGTGTGAGAAGTGCCACCTGGTGCTGTGCAGCCCGAAGCAGACCGAGTGTGGGCACCGCTTCTGCGAGAGCTGCATGGCGGCCCTGCTGAGCT
CTTCAAGTCCAAAATGTACAGCGTGTCAAGAGAGCATCGTTAAAGATAAGGTGTTTAAGGATAATTGCTGCAAGAGAGAAATTCTGGCTCTTCAGATCTA
TTGTCGGAATGAAAGCAGAGGTTGTGCAGAGCAGTTAATGCTGGGACATCTGCTGGTGCATTTAAAAAATGATTGCCATTTTGAAGAACTTCCATGTGTG
CGTCCTGACTGCAAAGAAAAGGTCTTGAGGAAAGACCTGCGAGACCACGTGGAGAAGGCGTGTAAATACCGGGAAGCCACATGCAGCCACTGCAAGAGTC
AGGTTCCGATGATCGCGCTGCAGAAACACGAAGACACCGACTGTCCCTGCGTGGTGGTGTCCTGCCCTCACAAGTGCAGCGTCCAGACTCTCCTGAGGAG
CGAGGGGACAAACCAGCAGATCAAGGCCCACGAGGCCAGCTCCGCCGTGCAGCACGTCAACCTGCTGAAGGAGTGGAGCAACTCGCTCGAAAAGAAGGTT
TCCTTGTTGCAGAATGAAAGTGTAGAAAAAAACAAGAGCATACAAAGTTTGCACAATCAGATATGTAGCTTTGAAATTGAAATTGAGAGACAAAAGGAAA
TGCTTCGAAATAATGAATCCAAAATCCTTCATTTACAGCGAGTGATAGACAGCCAAGCAGAGAAACTGAAGGAGCTTGACAAGGAGATCCGGCCCTTCCG
GCAGAACTGGGAGGAAGCAGACAGCATGAAGAGCAGCGTGGAGTCCCTCCAGAACCGCGTGACCGAGCTGGAGAGCGTGGACAAGAGCGCGGGGCAAGTG
GCTCGGAACACAGGCCTGCTGGAGTCCCAGCTGAGCCGGCATGACCAGATGCTGAGTGTGCACGACATCCGCCTAGCCGACATGGACCTGCGCTTCCAGG
TCCTGGAGACCGCCAGCTACAATGGAGTGCTCATCTGGAAGATTCGCGACTACAAGCGGCGGAAGCAGGAGGCCGTCATGGGGAAGACCCTGTCCCTTTA
CAGCCAGCCTTTCTACACTGGTTACTTTGGCTATAAGATGTGTGCCAGGGTCTACCTGAACGGGGACGGGATGGGGAAGGGGACGCACTTGTCGCTGTTT
TTTGTCATCATGCGTGGAGAATATGATGCCCTGCTTCCTTGGCCGTTTAAGCAGAAAGTGACACTCATGCTGATGGATCAGGGGTCCTCTCGACGTCATT
TGGGAGATGCATTCAAGCCCGACCCCAACAGCAGCAGCTTCAAGAAGCCCACTGGAGAGATGAATATCGCCTCTGGCTGCCCAGTCTTTGTGGCCCAAAC
TGTTCTAGAAAATGGGACATATATTAAAGATGATACAATTTTTATTAAAGTCATAGTGGATACTTCGGATCTGCCCGATCCCTGATAAGTAGCTGGGGAG
GTGGATTTAGCAGAAGGCAACTCCTCTGGGGGATTTGAACCGGTCTGTCTTCACTGAGGTCCTCGCGCTCAGAAAAGGACCTTGTGAGACGGAGGAAGCG
GCAGAAGGCGGACGCGTGCCGGCGGGAGGAGCCACGCGTGAGCACACCTGACACGTTTTATAATAGACTAGCCACACTTCACTCTGAAGAATTATTTATC
CTTCAACAAGATAAATATTGCTGTCAGAGAAGGTTTTCATTTTCATTTTTAAAGATCTAGTTAATTAAGGTGGAAAACATATATGCTAAACAAAAGAAAC
ATGATTTTTCTTCCTTAAACTTGAACACCAAAAAAACACACACACACACACACGTGGGGATAGCTGGACATGTCAGCATGTTAAGTAAAAGGAGAATTTA
TGAAATAGTAATGCAATTCTGATATCTTCTTTCTAAAATTCAAGAGTGCAATTTTGTTTCAAATACAGTATATTGTCTATTTTTAAGGCCTCATCTGGTC
TCTGTTTTAATAATTTGTTTGTCAGAAGACCCTGAAGTATATACCTAGGTCTTTTTTTTGAAAGTCTCTAAATTCAGAATCATTTTTTAATTTAAAGTTC
TACAAATAATTGTTACTGCAAACATTTTATTTTAAAACGTTGATAGACTGATATTTCTTGGAAGAAAATATAAAATATCAAACACTGGTTATCACTTGTG
ATAGGAAAGAGAATATTCAACCTGTTGTTATTTCTCGTTAGAAATGTAAACCTTCAAATATCTGTCGTAGTTAATGACACGACTTCACAATTCTGAACGG
AGCCTCGCTCATGGATGCTGTGCATCATTTTCAGATTTATAATTGTTTTCACCCTAAAATAGGGCATCCGTTGAACTTTGGAGTTCTAAACAAAATCCTG
TAGGTGTTTGGATTCTGCCCCATGTGTTCGGACGAGCTCTCTGTTGCTGACAGCACCGGCCTTCGGTCTCCATGTCAGGGGTGGGCGGGTGACTGCTGAG
GGAGGCCCGCAGGTGTGTTTCTCCATCCCGTCATCTTGCTGCATGCCGTCAACGGTCTCCGAAAGCAACGTTGTGCGTAGAGCTGGTGGCATACGGCCCA
CGTGCCTTAGATGGGACATGCTGCTTCTCCACCCTGGGTTTGCATTGAGCATCATTCTAGAAAGTGCTAGTTTAACCAGACTTTTCTCTCCACCACTAGA
TCTTTGTCTCTACAAGGGCCCTCAGACACCTCTGCACCTGCTGAGGGGAAGCCAGGCTCCACCGTCGGCTTCTGGAGCCTCCGCTGCTTAATTACCACAG
ATTCCAAATCTCTAGGCCCCACGAGTGAGCCGCCTGGTCCAAGTACGGCCTGGTCCCACCCTGAGGGAGGCAGGTGTGGAACAGAAGCCGAGCCTCTCCG
TGTCCCCACCGGGGCCGTGGGCACCCCCACAGCCCGAAGCAGAACCCTCTGAGCATTCCAGAGACCGCTGCTCGGGGGCCTGCCCAGGCTGACCAACGGG
CGCTCCTGACCACCACCCTGGCGGGAAGGGTGGCCACGGGGCCCGTCGTCCCAGCCTGTGCCTGCCCAGATGGCATTTTCTCAACTCACTGTTTACTGTC
TCTCAGTGTCCAACTGTGATTAGAAGCCTGGAGCCTGCCCCCTGCACCCCTTTTGCTATGCACCACGCTTCATGGTGCTCTTACCACTGATGGGTGCTAC
ACGCGACGGGTGCTTCTTAGGCAAAACCAATGTGTGCGAACTGTCACACCTGTGCCACTCGCCCACAAGCCGCGCCCACAATTGGCCAGCTGGGCCGTGC
ACGTCAGACTGCCTGCCTCGGCTCTCCCCGTGGCCGCGCGGGGACAGCTTGGTGGGTGCCCGGTGGCCCACCTGTCTCTGGTGCTGCCATCTGTCCTGGG
TGTGCCTTCGCCCCAGTGCCTGCTGGAAGTGCCCTCCGTCGCACCCCTGTGCCCTGAGCTCCCGTGAGGGGCCCGCCGCGCCCTTTCGCGGTCGAAGCGT
TCCGTTGTTCTTATCTGCCTTTCCTTTCCCCGCTCTCCTGGGATTACTTTGGGGGAATGAGTATCCTTGGTTCTGCCCTGTGAGGGAGTCGTGTGTCCCT
GCTCATAAAGGAAGGACTTCCTGCAGAAGCTGCGGAAAACTACTGTTCCCTCGAAGGTGTCCCCCACCTGAGGCCTGTCCCCTACCTGCCCTCAGGTAGT
TTTCCTGAGGCCAGGGGTTAACAACAGGGACATCCCTGCAACTTCCCCTTCACAAAATGTATAATATTAGATGAAGGATATGCAACATCTTGGTCTAGTA
AGAACCGTTTCCTCCCCTCTGGGTTGAAGTCCTGGTGTGGCCCCCAGAAGCAGCAGTGCGTGTCACTGGGACGTCTCCAGTAGCCCTTCCCAGGCAGACG
CTCCTGGCGGGACGCCATGGGGCCCACCTGAGGGTCCCACAGACGTAACCTGAGTGACAGGAGTCCTTGAGGATGGGATGGCCTATGTCACACACTTTGT
CCTTGAACCTGAGTGATGGGGGTCCTTGAGGATGGGATGGCCTGTGTCACGCGCTTTGTCTTTGTGTTTGGTTGTATCGGGGTCTCTGTTCTGAGTGTGT
CTTCCTCTCATGTACTCAACACAGTGGGCAGCAGCCTGGGACGGCGTCCCCTCTCCCGGCGGCGGGCAAGCCTTGCGCTGCTCCACCCTCGGCCTGGGCA
CCCTCACTTGGCGCTGGCCACCTGGGCCAGCCTGGGGCCATGGTCTCTCTGCAGCTGAGGCCCAGTGGCCCCTTGGGCAGTGATCGGCCCTCCCCGCATC
ACAGGGCCCTGGCAGCAAGCGGGAAATGGGGGCGCACACTGTGTGCTTGGGGGTGCTGCTTGTTTACCACACATGACCAGACTCCCAGCAGGACAGAGCT
GCTCAGTACTTTACAGAAACCAACTGAGTCGTTTGTGCATGAATTAAGCCGGTCTGCTTCCCCGTCACCTTCGTAACAAAACAACGTCCCCTCTCCCCTC
GCCTCGAGCAGTTTCTTCAGGACACCGTGGCTCGGGCTGCTCCCTGCTGCCAGGCACGCTGGTTGGCTGGCCTGGGCCCGGCTCACGTGAAGGGCACTGG
CTCTTGTGACCACACTGAGCCACGTGCAAGCCGCAGCCGGGCCTGGAAGCCTGACCCTCTGGTTCTAGGGCTTGTCCCGCGGAGCCTGCAGAGCTAGACG
TTGGGGTGTGTCCGTGATGATATGGGGGCCAGGCTGGGAGTAGGGCCTTTCTAGCAGGGTTGGGTGGCTCAGTGAGGGTGTGGAAGTGGGGGACCCACGG
GGCCTGGCTTTGGGACTAGACATGCCAGCCCCAGCTGGGCTGGAGGGAGCCTGAGTGAGCCCCGACATACGCTGGGCCTTTCAGCTCGCCGTGCTCTGGT
GACACACAGGCGGCCAGGTTGGGATTTGTGTCAATTCTAGGAGCCATCAAGCATGAATGTGGTTCTGTCTCCTGAGCGCAAGCCTCGCCGGACCCCTGGG
CGAAGGCCTGGACTTGCAGATGTGTGTTCCCTGTGCGGGTGGACAGAGGGGGCCCTTATGACCCACATTGCAGCCCCATTCCACCACCCCTTCCTCCCCA
GAGCAGTCTCTGCCGAGGGACAGCACCTGTGTCCCTTCGATGCCACAACAGCCAGTTGAACAGGGGAGCCCTTTGCTCAGGCAGCTTCTCCTGCCTCTCC
CTCCTTTCTCCTTCCCTGCCCCATCCCCGTGCCCTTCTTGGCCTGTGGCGCTGGGGAGCCATGGTGTGGCATACTGGGGCTCCTGCTCCTTGGGCCACTT
CCTCAGCCCGGGCCCCACAGGCCCACCACCTGCCAGGGCTCCCACTGCACTGGCTGTGGCAGGAGGCTTCCCCATGACCCCGTGTGGCCCAGCTCGGTGA
GGATGCAGTTCTAGGCACAGCCCCTGGGACAGCCAGCTGCCTCCCAGACCACGTCAGCCTGCTCCAGGGTCCTCAGTCACCCTGGGCCAGGGGCCACGTG
TCCCATGGATGTCGACCATGCCAACGTCACATTCCAGCACCCCTTTTGCTTGATGGCGTCTGGTGGTAGTCAGCATGGTGGACCCACATCCTACAGCCAG
AGGTGATGTTGGACAAAGGAAGGGGAGTCTGGATGGGTCCTTAAACGACCATTCTGTCCGCAGCGGGGTCATTCCTTGTCAGCCCAAGGGAGGGCCGGGG
AGTACACTGATCCCAACAGCTGGGCTGACACCTCCTTTCTCCCCTGCACGGGGAGGATTGGCCTGAGGACCGTCACCCTGTGCACAGCCCCAGTAGGGTG
GCAGTGCCACTGTCTCCTTGGGCCGTTGCAGGATTGGGCGGGTGCAGACTCCCCTTGCGGGCCCCTTGCTCAATCCCCGGCCCTCCCAGACTCCTCCCTC
TACTGGGGGTAATTTGTGTGTCAGAAGGGCTCTGGCAGAGCTGTAAAATACTGTTTTTTAAAAATTTTAGTCCAGATCTTTACTTATTAGACTGCAGAAG
GAGAGCTAGGGAGAGTGGGGGAAGCCCCCTTGCTTTTGTATCTGTGAGGTGAATGAGGGTCTGTCACCCAAATCTACTTCTCAGCCCATGACCATAGTTC
TGTTTTCCGTTTGCAAATCTCAGTAGCTCTGTTTTCTCCAAAGTAGAATGTGCGCACCGGGGTCCTAGCCAGGCGAGGTCAGTGTCGGCAGGCTACCTGG
TCATTATTGCTGCCTCGTCCAGGCTGATGCTGATGGTCACAGGCACGGTGGCATCAGGGAGCCGGGCCAGCAGGCGGCGTGAGGCGGGGCCAGCAGCTCA
CTGCAAGGGCATTTTCCACCTGATCCTGGTGTGCCCCACATGCGGTGGCAGGGCAGACGTGTGAAGCCTCGGCCGTCTCGGGGCTGGCAGGTGTGCGGGT
GAGGAGGCCCCGGTGGCCAAGCAGAGCCTGCGTTTCATTTCTCCTGCTGCACTGTGTCTAGTCTGTCTTGTGAACTCTCACCGTGAAAAGAGGCTAGAAG
TCCAGGATCGCTGTACCGCTCCTGTAATTAGGTGATGACTGGATTTGACAACTTAGTCCCCTCAGACAAGTAAGATACCCTCCAACAGCAAATTCAATGA
CTTAATTGGAAAACACACAAGCTGGCATGATGTCCGGTGATTTCTGTAAGAAATGCCTGTAGGAGAAGGTCTGTGAAGTGTGGAGGGCAGTGTCGACGCT
GCACAGCATCTGCAGATTCGCAGCCTCTTCTCTGCCGGTGCCTCTGTTCGGTTCTGTTACCCAAAAACAAAGACCAAAGAAGGCCAATCTCTCATTTGAC
CCTGTCTTTTTAATCTGCCTGTTTTAAAAGTTGCGTCTGTAGTAGCCGCTTGCTGTGAAGACACATCTTGACAGTCCAAGTGATTTTGTGACCAGTGATT
TGGGTCCTGTTTTCCGCTCTTCTAAGAAAAAACAAAAAGACCGTGAGTTATTGCCCAGCAATAATCATGTTGTTACTGTGAGTTAGCAACATGCCTGACT
TCCTGATAGCATTACTGTTTTCTAGTTTTGTTTATTGTATATTATGTGTGGTTTTATTTGGTATTTATTTGTGTTTTGAGGTCTTGCAATGTTTTTGTGT
TTCTGATGCTAATAACTAAAGTTTGTAAGACTGTAGAATGCAAAACTCGGAGATGCTAAACTGTCTTATTAGAGGAAAATAAATCTGATTATGGAGTCTC
A
- TRAF3.u.f.1 (forward primer)
- TRAF3.u.r.3 (reverse primer)
- Single exon skipping
Frame 0
GSAARPPRARAGVAAQPGLSSRRQPRRPPALPRPPPWGSPGSRTLRTAAEDAPGAPEPAERRRTAR*
GK*GPKK*CHLVKVPEQVRIRPRIRNLAPGSWL
PTLLRIAVLTEENSSFLKWSRVKRWTLLARCRL
TRR*SCTLTAVLGRQFLSLNKEVTRKSL*RPWRT
STSVRSATWCCAARSRPSVGTASARAAWRPC*A
LQVQNVQRVKRASLKIRCLRIIAAREKFWLFRS
IVGMKAEVVQSS*CWDICWCI*KMIAILKNFHVC
VLTAKKRS*GKTCETTWRRRVNTGKPHAATARV
RFR*SRCRNTKTPTVPAWWCPALTSAASRLS*G
ARGQTSRSRPTRPAPPCSTSTC*RSGATRSKRRF
PCCRMKV*KKTRAYKVCTIRYVALKLKLRDKRK
CFEIMNPKSFIYSE**TAKQRN*RSLTRRSGPS
GRTGRKQTA*RAAWSPSRTA*PSWRAWTRARGKW
LGTQACWSPS*AGMTRC*VCTTSA*PTWTCASR
SWRPPATMECSSGRFATTSGGSRRPSWGRPCPF
TASLSTLVTLAIRCVPGST*TGTGWGRGRTCRCF
LSSCVENMMPCFLGRLSRK*HSC*WIRGPLDVI
WEMHSSPTPTAAASRSPLER*ISPLAAQSLWPK
LF*KMGHILKMIQFLLKS*WILRICPIPDK*LGR
WI*QKATPLGDLNRSVFTEVLALRKGPCETEEA
AEGGRVPAGGATREHT*HVL**TSHTSL*RIIY
PSTR*ILLSEKVFIFIFKDLVN*GGKHIC*TKET
*FFFLKLEHQKNTHTHTRGDSWTCQHVK*KENL
*NSNAILISSF*NSRVQFCFKYSILSIFKASSG
LCFNNLFVRRP*SIYLGLFFESL*IQNHFLI*SS
TNNCYCKHFILKR**TDISWKKI*NIKHWLSLV
IGKRIFNLLLFLVRNVNLQISVVVNDTTSQF*T
EPRSWMLCIIFRFIIVFTLK*GIR*TLEF*TKSC
RCLDSAPCVRTSSLLLTAPAFGLHVRGGRVTAE
GGPQVCFSIPSSCCMPSTVSESNVVRRAGGIRP
TCLRWDMLLLHPGFALSIILESASLTRLFSPPLD
LCLYKGPQTPLHLLRGSQAPPSASGASAA*LPQ
IPNL*APRVSRLVQVRPGPTLREAGVEQKPSLS
VSPPGPWAPPQPEAEPSEHSRDRCSGACPG*PTG
APDHHPGGKGGHGARRPSLCLPRWHFLNSLFTV
SQCPTVIRSLEPAPCTPFAMHHASWCSYH*WVL
HATGAS*AKPMCANCHTCATRPQAAPTIGQLGRA
RQTACLGSPRGRAGTAWWVPGGPPVSGAAICPG
CAFAPVPAGSALRRTPVP*APVRGPPRPFAVEA
FRCSYLPFLSPLSWDYFGGMSILGSAL*GSRVSL
LIKEGLPAEAAENYCSLEGVPHLRPVPYLPSGS
FPEARG*QQGHPCNFPFTKCIILDEGYATSWSS
KNRFLPSGLKSWCGPQKQQCVSLGRLQ*PFPGRR
SWRDAMGPT*GSHRRNLSDRSP*GWDGLCHTLC
P*T*VMGVLEDGMACVTRFVFVFGCIGVSVLSV
SSSHVLNTVGSSLGRRPLSRRRASLALLHPRPGH
PHLALATWASLGPWSLCS*GPVAPWAVIGPPRI
TGPWQQAGNGGAHCVLGGAACLPHMTRLPAGQS
CSVLYRNQLSRLCMN*AGLLPRHLRNKTTSPLPS
PRAVSSGHRGSGCSLLPGTLVGWPGPGSREGHW
LL*PH*ATCKPQPGLEA*PSGSRACPAEPAELD
VGVCP**YGGQAGSRAFLAGLGGSVRVWKWGTHG
AWLWD*TCQPQLGWREPE*APTYAGPFSSPCSG
DTQAARLGFVSILGAIKHECGSVS*AQASPDPW
AKAWTCRCVFPVRVDRGGPYDPHCSPIPPPLPPQ
SSLCRGTAPVSLRCHNSQLNRGALCSGSFSCLS
LLSPSLPHPRALLGLWRWGAMVWHTGAPAPWAT
SSARAPQAHHLPGLPLHWLWQEASP*PRVAQLGE
DAVLGTAPGTASCLPDHVSLLQGPQSPWARGHV
SHGCRPCQRHIPAPLLLDGVWW*SAWWTHILQP
EVMLDKGRGVWMGP*TTILSAAGSFLVSPREGRG
VH*SQQLG*HLLSPLHGEDWPEDRHPVHSPSRV
AVPLSPWAVAGLGGCRLPLRAPCSIPGPPRLLP
LLGVICVSEGLWQSCKILFFKNFSPDLYLLDCRR
RARESGGSPLAFVSVR*MRVCHPNLLLSP*P*F
CFPFANLSSSVFSKVECAHRGPSQARSVSAGYL
VIIAASSRLMLMVTGTVASGSRASRRREAGPAAH
CKGIFHLILVCPTCGGRADV*SLGRLGAGRCAG
EEAPVAKQSLRFISPAALCLVCLVNSHREKRLE
VQDRCTAPVIR**LDLTT*SPQTSKIPSNSKFND
LIGKHTSWHDVR*FL*EMPVGEGL*SVEGSVDA
AQHLQIRSLFSAGASVRFCYPKTKTKEGQSLI*
PCLFNLPVLKVASVVAACCEDTS*QSK*FCDQ*F
GSCFPLF*EKTKRP*VIAQQ*SCCYCELATCLT
S**HYCFLVLFIVYYVWFYLVFICVLRSCNVFV
FLMLITKVCKTVECKTRRC*TVLLEENKSDYGVS
Frame 1
GARRGRRVREPGLQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRD
EENEAQRSDATWLRSQSRSESDLGSETWLLAPGS
LLF*GSLS*QKRTPLS*NGVE*KDGLSWRAAD*
PAAKAAH*PQCWDASFCP*TRRLQGKVCEDRGG
QVQV*EVPPGAVQPEADRVWAPLLRELHGGPAEL
FKSKMYSVSREHR*R*GV*G*LLQERNSGSSDL
LSE*KQRLCRAVNAGTSAGAFKK*LPF*RTSMC
AS*LQRKGLEERPARPRGEGV*IPGSHMQPLQES
GSDDRAAETRRHRLSLRGGVLPSQVQRPDSPEE
RGDKPADQGPRGQLRRAARQPAEGVEQLARKEG
FLVAE*KCRKKQEHTKFAQSDM*L*N*N*ETKGN
ASK**IQNPSFTASDRQPSRETEGA*QGDPALP
AELGGSRQHEEQRGVPPEPRDRAGERGQERGAS
GSEHRPAGVPAEPA*PDAECARHPPSRHGPALPG
PGDRQLQWSAHLEDSRLQAAEAGGRHGEDPVPL
QPAFLHWLLWL*DVCQGLPERGRDGEGDALVAV
FCHHAWRI*CPASLAV*AESDTHADGSGVLSTSF
GRCIQARPQQQQLQEAHWRDEYRLWLPSLCGPN
CSRKWDIY*R*YNFY*SHSGYFGSARSLISSWG
GGFSRRQLLWGI*TGLSSLRSSRSEKDLVRRRKR
QKADACRREEPRVSTPDTFYNRLATLHSEELFI
LQQDKYCCQRRFSFSFLKI*LIKVENIYAKQKK
HDFSSLNLNTKKTHTHTHVGIAGHVSMLSKRRIY
EIVMQF*YLLSKIQECNFVSNTVYCLFLRPHLV
SVLIICLSEDPEVYT*VFFLKVSKFRIIF*FKV
LQIIVTANILF*NVDRLIFLGRKYKISNTGYHL*
*EREYSTCCYFSLEM*TFKYLS*LMTRLHNSER
SLAHGCCASFSDL*LFSP*NRASVELWSSKQNP
VGVWILPHVFGRALCC*QHRPSVSMSGVGG*LLR
EARRCVSPSRHLAACRQRSPKATLCVELVAYGP
RALDGTCCFSTLGLH*ASF*KVLV*PDFSLHH*
IFVSTRALRHLCTC*GEARLHRRLLEPPLLNYHR
FQISRPHE*AAWSKYGLVPP*GRQVWNRSRASP
CPHRGRGHPHSPKQNPLSIPETAARGPAQADQR
ALLTTTLAGRVATGPVVPACACPDGIFSTHCLLS
LSVQL*LEAWSLPPAPLLLCTTLHGALTTDGCY
TRRVLLRQNQCVRTVTPVPLAHKPRPQLASWAV
HVRLPASALPVAARGQLGGCPVAHLSLVLPSVLG
VPSPQCLLEVPSVAPLCPELP*GARRALSRSKR
SVVLICLSFPRSPGITLGE*VSLVLPCEGVVCP
CS*RKDFLQKLRKTTVPSKVSPT*GLSPTCPQVV
FLRPGVNNRDIPATSPSQNV*Y*MKDMQHLGLV
RTVSSPLG*SPGVAPRSSSACHWDVSSSPSQAD
APGGTPWGPPEGPTDVT*VTGVLEDGMAYVTHFV
LEPE*WGSLRMGWPVSRALSLCLVVSGSLF*VC
LPLMYSTQWAAAWDGVPSPGGGQALRCSTLGLG
TLTWRWPPGPAWGHGLSAAEAQWPLGQ*SALPAS
QGPGSKREMGAHTVCLGVLLVYHT*PDSQQDRA
AQYFTETN*VVCA*IKPVCFPVTFVTKQRPLSP
RLEQFLQDTVARAAPCCQARWLAGLGPAHVKGTG
SCDHTEPRASRSRAWKPDPLVLGLVPRSLQS*T
LGCVRDDMGARLGVGPF*QGWVAQ*GCGSGGPT
GPGFGTRHASPSWAGGSLSEPRHTLGLSARRALV
THRRPGWDLCQF*EPSSMNVVLSPERKPRRTPG
RRPGLADVCSLCGWTEGALMTHIAAPFHHPFLP
RAVSAEGQHLCPFDATTAS*TGEPFAQAASPASP
SFLLPCPIPVPFLACGAGEPWCGILGLLLLGPL
PQPGPHRPTTCQGSHCTGCGRRLPHDPVWPSSV
RMQF*AQPLGQPAASQTTSACSRVLSHPGPGATC
PMDVDHANVTFQHPFCLMASGGSQHGGPTSYSQ
R*CWTKEGESGWVLKRPFCPQRGHSLSAQGRAG
EYTDPNSWADTSFLPCTGRIGLRTVTLCTAPVGW
QCHCLLGPLQDWAGADSPCGPLAQSPALPDSSL
YWG*FVCQKGSGRAVKYCFLKILVQIFTY*TAE
GELGRVGEAPLLLYL*GE*GSVTQIYFSAHDHSS
VFRLQISVALFSPK*NVRTGVLARRGQCRQATW
SLLLPRPG*C*WSQARWHQGAGPAGGVRRGQQL
TARAFST*SWCAPHAVAGQTCEASAVSGLAGVRV
RRPRWPSRACVSFLLLHCV*SVL*TLTVKRG*K
SRIAVPLL*LGDDWI*QLSPLRQVRYPPTANSM
T*LENTQAGMMSGDFCKKCL*EKVCEVWRAVSTL
HSICRFAASSLPVPLFGSVTQKQRPKKANLSFD
PVFLICLF*KLRL**PLAVKTHLDSPSDFVTSD
LGPVFRSSKKKQKDRELLPSNNHVVTVS*QHA*L
PDSITVF*FCLLYIMCGFIWYLFVF*GLAMFLC
F*C**LKFVRL*NAKLGDAKLSY*RKINLIMES
Frame 2
ERGAAAACASRGCSPAGTFQPAAAAAAAGSSPPPAMGQPGEQNAADRGGGRARRP*AGRAATDREM
RKMRPKEVMPLG*GPRAGQNQT*DQKPGSWLLA
PYSSKDRCPDRRELLFPKMESSKKMDSPGALQTN
PPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVED
KYKCEKCHLVLCSPKQTECGHRFCESCMAALLS
SSSPKCTACQESIVKDKVFKDNCCKREILALQIY
CRNESRGCAEQLMLGHLLVHLKNDCHFEELPCV
RPDCKEKVLRKDLRDHVEKACKYREATCSHCKS
QVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRS
EGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKV
SLLQNESVEKNKSIQSLHNQICSFEIEIERQKE
MLRNNESKILHLQRVIDSQAEKLKELDKEIRPFR
QNWEEADSMKSSVESLQNRVTELESVDKSAGQV
ARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQ
VLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLY
SQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLF
FVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRH
LGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQT
VLENGTYIKDDTIFIKVIVDTSDLPDP**VAGE
VDLAEGNSSGGFEPVCLH*GPRAQKRTL*DGGS
GRRRTRAGGRSHA*AHLTRFIID*PHFTLKNYLS
FNKINIAVREGFHFHF*RSS*LRWKTYMLNKRN
MIFLP*T*TPKKHTHTHTWG*LDMSAC*VKGEF
MK**CNSDIFFLKFKSAILFQIQYIVYF*GLIWS
LF**FVCQKTLKYIPRSFF*KSLNSESFFNLKF
YK*LLLQTFYFKTLID*YFLEENIKYQTLVITC
DRKENIQPVVISR*KCKPSNICRS**HDFTILNG
ASLMDAVHHFQIYNCFHPKIGHPLNFGVLNKIL
*VFGFCPMCSDELSVADSTGLRSPCQGWAGDC*
GRPAGVFLHPVILLHAVNGLRKQRCA*SWWHTAH
VP*MGHAASPPWVCIEHHSRKC*FNQTFLSTTR
SLSLQGPSDTSAPAEGKPGSTVGFWSLRCLITT
DSKSLGPTSEPPGPSTAWSHPEGGRCGTEAEPLR
VPTGAVGTPTARSRTL*AFQRPLLGGLPRLTNG
RS*PPPWREGWPRGPSSQPVPAQMAFSQLTVYC
LSVSNCD*KPGACPLHPFCYAPRFMVLLPLMGAT
RDGCFLGKTNVCELSHLCHSPTSRAHNWPAGPC
TSDCLPRLSPWPRGDSLVGARWPTCLWCCHLSW
VCLRPSACWKCPPSHPCALSSREGPAAPFRGRSV
PLFLSAFPFPALLGLLWGNEYPWFCPVRESCVP
AHKGRTSCRSCGKLLFPRRCPPPEACPLPALR*
FS*GQGLTTGTSLQLPLHKMYNIR*RICNILV**
EPFPPLWVEVLVWPPEAAVRVTGTSPVALPRQT
LLAGRHGAHLRVPQT*PE*QESLRMGWPMSHTL
SLNLSDGGP*GWDGLCHALCLCVWLYRGLCSECV
FLSCTQHSGQQPGTASPLPAAGKPCAAPPSAWA
PSLGAGHLGQPGAMVSLQLRPSGPLGSDRPSPH
HRALAASGKWGRTLCAWGCCLFTTHDQTPSRTEL
LSTLQKPTESFVHELSRSASPSPS*QNNVPSPL
ASSSFFRTPWLGLLPAARHAGWLAWARLT*RAL
ALVTTLSHVQAAAGPGSLTLWF*GLSRGACRARR
WGVSVMIWGPGWE*GLSSRVGWLSEGVEVGDPR
GLALGLDMPAPAGLEGA*VSPDIRWAFQLAVLW
*HTGGQVGICVNSRSHQA*MWFCLLSASLAGPLG
EGLDLQMCVPCAGGQRGPL*PTLQPHSTTPSSP
EQSLPRDSTCVPSMPQQPVEQGSPLLRQLLLPL
PPFSFPAPSPCPSWPVALGSHGVAYWGSCSLGHF
LSPGPTGPPPARAPTALAVAGGFPMTPCGPAR*
GCSSRHSPWDSQLPPRPRQPAPGSSVTLGQGPR
VPWMSTMPTSHSSTPFA*WRLVVVSMVDPHPTAR
GDVGQRKGSLDGSLNDHSVRSGVIPCQPKGGPG
STLIPTAGLTPPFSPARGGLA*GPSPCAQPQ*G
GSATVSLGRCRIGRVQTPLAGPLLNPRPSQTPPS
TGGNLCVRRALAEL*NTVF*KF*SRSLLIRLQK
ES*GEWGKPPCFCICEVNEGLSPKSTSQPMTIV
LFSVCKSQ*LCFLQSRMCAPGS*PGEVSVGRLPG
HYCCLVQADADGHRHGGIREPGQQAA*GGASSS
LQGHFPPDPGVPHMRWQGRRVKPRPSRGWQVCG
*GGPGGQAEPAFHFSCCTVSSLSCELSP*KEARS
PGSLYRSCN*VMTGFDNLVPSDK*DTLQQQIQ*
LNWKTHKLA*CPVISVRNACRRRSVKCGGQCRR
CTASADSQPLLCRCLCSVLLPKNKDQRRPISHLT
LSF*SACFKSCVCSSRLL*RHILTVQVIL*PVI
WVLFSALLRKNKKTVSYCPAIIMLLL*VSNMPD
FLIALLFSSFVYCILCVVLFGIYLCFEVLQCFCV
SDANN*SL*DCRMQNSEMLNCLIRGK*I*LWSL
Sequence TRAF3.bAug05
GGGAGCGCGGCGCGGCCGCCGCGTGCGCGAGCCGGGGTTGCAGCCCAGCCGGGACTTTCCAGCCGGCGGCAGCCGCGGCGGCCGCCGGCTCTTCCCCGCCCCCCGCCATGGGGCAGCCCGGGGAGCAGAACGCTGCGGACCGCGGCGGAGGACGCGCCCGGCGCCCCTGAGCCGGCCGAGCGGCGACGGACCGCGAGATG
AGGAAAATGAGGCCCAAAGAAGTGATGCCACTTGGTTAAGGTCCCAGAGCAGGTCAGAATCAGACCTAGGATCAGAAACCTGGCTCCTGGCTCCTGGCTC
CCTACTCTTCTAAGGATCGCTGTCCTGACAGAAGAGAACTCCTCTTTCCTAAAATGGAGTCGAGTAAAAAGATGGACTCTCCTGGCGCGCTGCAGACTAA
CCCGCCGCTAAAGCTGCACACTGACCGCAGTGCTGGGACGCCAGTTTTTGTCCCTGAACAAGGAGGTTACAAGGAAAAGTTTGTGAAGACCGTGGAGGAC
AAGTACAAGTGTGAGAAGTGCCACCTGGTGCTGTGCAGCCCGAAGCAGACCGAGTGTGGGCACCGCTTCTGCGAGAGCTGCATGGCGGCCCTGCTGAGCT
CTTCAAGTCCAAAATGTACAGCGTGTCAAGAGAGCATCGTTAAAGATAAGGTGTTTAAGGATAATTGCTGCAAGAGAGAAATTCTGGCTCTTCAGATCTA
TTGTCGGAATGAAAGCAGAGGTTGTGCAGAGCAGTTAATGCTGGGACATCTGCTGGTGCATTTAAAAAATGATTGCCATTTTGAAGAACTTCCATGTGTG
CGTCCTGACTGCAAAGAAAAGGTCTTGAGGAAAGACCTGCGAGACCACGTGGAGAAGGCGTGTAAATACCGGGAAGCCACATGCAGCCACTGCAAGAGTC
AGGTTCCGATGATCGCGCTGCAGAAACACGAAGACACCGACTGTCCCTGCGTGGTGGTGTCCTGCCCTCACAAGTGCAGCGTCCAGACTCTCCTGAGGAG
CGAGTTGAGTGCACACTTGTCAGAGTGTGTCAATGCCCCCAGCACCTGTAGTTTTAAGCGCTATGGCTGCGTTTTTCAGGGGACAAACCAGCAGATCAAG
GCCCACGAGGCCAGCTCCGCCGTGCAGCACGTCAACCTGCTGAAGGAGTGGAGCAACTCGCTCGAAAAGAAGGTTTCCTTGTTGCAGAATGAAAGTGTAG
AAAAAAACAAGAGCATACAAAGTTTGCACAATCAGATATGTAGCTTTGAAATTGAAATTGAGAGACAAAAGGAAATGCTTCGAAATAATGAATCCAAAAT
CCTTCATTTACAGCGAGTGATAGACAGCCAAGCAGAGAAACTGAAGGAGCTTGACAAGGAGATCCGGCCCTTCCGGCAGAACTGGGAGGAAGCAGACAGC
ATGAAGAGCAGCGTGGAGTCCCTCCAGAACCGCGTGACCGAGCTGGAGAGCGTGGACAAGAGCGCGGGGCAAGTGGCTCGGAACACAGGCCTGCTGGAGT
CCCAGCTGAGCCGGCATGACCAGATGCTGAGTGTGCACGACATCCGCCTAGCCGACATGGACCTGCGCTTCCAGGTCCTGGAGACCGCCAGCTACAATGG
AGTGCTCATCTGGAAGATTCGCGACTACAAGCGGCGGAAGCAGGAGGCCGTCATGGGGAAGACCCTGTCCCTTTACAGCCAGCCTTTCTACACTGGTTAC
TTTGGCTATAAGATGTGTGCCAGGGTCTACCTGAACGGGGACGGGATGGGGAAGGGGACGCACTTGTCGCTGTTTTTTGTCATCATGCGTGGAGAATATG
ATGCCCTGCTTCCTTGGCCGTTTAAGCAGAAAGTGACACTCATGCTGATGGATCAGGGGTCCTCTCGACGTCATTTGGGAGATGCATTCAAGCCCGACCC
CAACAGCAGCAGCTTCAAGAAGCCCACTGGAGAGATGAATATCGCCTCTGGCTGCCCAGTCTTTGTGGCCCAAACTGTTCTAGAAAATGGGACATATATT
AAAGATGATACAATTTTTATTAAAGTCATAGTGGATACTTCGGATCTGCCCGATCCCTGATAAGTAGCTGGGGAGGTGGATTTAGCAGAAGGCAACTCCT
CTGGGGGATTTGAACCGGTCTGTCTTCACTGAGGTCCTCGCGCTCAGAAAAGGACCTTGTGAGACGGAGGAAGCGGCAGAAGGCGGACGCGTGCCGGCGG
GAGGAGCCACGCGTGAGCACACCTGACACGTTTTATAATAGACTAGCCACACTTCACTCTGAAGAATTATTTATCCTTCAACAAGATAAATATTGCTGTC
AGAGAAGGTTTTCATTTTCATTTTTAAAGATCTAGTTAATTAAGGTGGAAAACATATATGCTAAACAAAAGAAACATGATTTTTCTTCCTTAAACTTGAA
CACCAAAAAAACACACACACACACACACGTGGGGATAGCTGGACATGTCAGCATGTTAAGTAAAAGGAGAATTTATGAAATAGTAATGCAATTCTGATAT
CTTCTTTCTAAAATTCAAGAGTGCAATTTTGTTTCAAATACAGTATATTGTCTATTTTTAAGGCCTCATCTGGTCTCTGTTTTAATAATTTGTTTGTCAG
AAGACCCTGAAGTATATACCTAGGTCTTTTTTTTGAAAGTCTCTAAATTCAGAATCATTTTTTAATTTAAAGTTCTACAAATAATTGTTACTGCAAACAT
TTTATTTTAAAACGTTGATAGACTGATATTTCTTGGAAGAAAATATAAAATATCAAACACTGGTTATCACTTGTGATAGGAAAGAGAATATTCAACCTGT
TGTTATTTCTCGTTAGAAATGTAAACCTTCAAATATCTGTCGTAGTTAATGACACGACTTCACAATTCTGAACGGAGCCTCGCTCATGGATGCTGTGCAT
CATTTTCAGATTTATAATTGTTTTCACCCTAAAATAGGGCATCCGTTGAACTTTGGAGTTCTAAACAAAATCCTGTAGGTGTTTGGATTCTGCCCCATGT
GTTCGGACGAGCTCTCTGTTGCTGACAGCACCGGCCTTCGGTCTCCATGTCAGGGGTGGGCGGGTGACTGCTGAGGGAGGCCCGCAGGTGTGTTTCTCCA
TCCCGTCATCTTGCTGCATGCCGTCAACGGTCTCCGAAAGCAACGTTGTGCGTAGAGCTGGTGGCATACGGCCCACGTGCCTTAGATGGGACATGCTGCT
TCTCCACCCTGGGTTTGCATTGAGCATCATTCTAGAAAGTGCTAGTTTAACCAGACTTTTCTCTCCACCACTAGATCTTTGTCTCTACAAGGGCCCTCAG
ACACCTCTGCACCTGCTGAGGGGAAGCCAGGCTCCACCGTCGGCTTCTGGAGCCTCCGCTGCTTAATTACCACAGATTCCAAATCTCTAGGCCCCACGAG
TGAGCCGCCTGGTCCAAGTACGGCCTGGTCCCACCCTGAGGGAGGCAGGTGTGGAACAGAAGCCGAGCCTCTCCGTGTCCCCACCGGGGCCGTGGGCACC
CCCACAGCCCGAAGCAGAACCCTCTGAGCATTCCAGAGACCGCTGCTCGGGGGCCTGCCCAGGCTGACCAACGGGCGCTCCTGACCACCACCCTGGCGGG
AAGGGTGGCCACGGGGCCCGTCGTCCCAGCCTGTGCCTGCCCAGATGGCATTTTCTCAACTCACTGTTTACTGTCTCTCAGTGTCCAACTGTGATTAGAA
GCCTGGAGCCTGCCCCCTGCACCCCTTTTGCTATGCACCACGCTTCATGGTGCTCTTACCACTGATGGGTGCTACACGCGACGGGTGCTTCTTAGGCAAA
ACCAATGTGTGCGAACTGTCACACCTGTGCCACTCGCCCACAAGCCGCGCCCACAATTGGCCAGCTGGGCCGTGCACGTCAGACTGCCTGCCTCGGCTCT
CCCCGTGGCCGCGCGGGGACAGCTTGGTGGGTGCCCGGTGGCCCACCTGTCTCTGGTGCTGCCATCTGTCCTGGGTGTGCCTTCGCCCCAGTGCCTGCTG
GAAGTGCCCTCCGTCGCACCCCTGTGCCCTGAGCTCCCGTGAGGGGCCCGCCGCGCCCTTTCGCGGTCGAAGCGTTCCGTTGTTCTTATCTGCCTTTCCT
TTCCCCGCTCTCCTGGGATTACTTTGGGGGAATGAGTATCCTTGGTTCTGCCCTGTGAGGGAGTCGTGTGTCCCTGCTCATAAAGGAAGGACTTCCTGCA
GAAGCTGCGGAAAACTACTGTTCCCTCGAAGGTGTCCCCCACCTGAGGCCTGTCCCCTACCTGCCCTCAGGTAGTTTTCCTGAGGCCAGGGGTTAACAAC
AGGGACATCCCTGCAACTTCCCCTTCACAAAATGTATAATATTAGATGAAGGATATGCAACATCTTGGTCTAGTAAGAACCGTTTCCTCCCCTCTGGGTT
GAAGTCCTGGTGTGGCCCCCAGAAGCAGCAGTGCGTGTCACTGGGACGTCTCCAGTAGCCCTTCCCAGGCAGACGCTCCTGGCGGGACGCCATGGGGCCC
ACCTGAGGGTCCCACAGACGTAACCTGAGTGACAGGAGTCCTTGAGGATGGGATGGCCTATGTCACACACTTTGTCCTTGAACCTGAGTGATGGGGGTCC
TTGAGGATGGGATGGCCTGTGTCACGCGCTTTGTCTTTGTGTTTGGTTGTATCGGGGTCTCTGTTCTGAGTGTGTCTTCCTCTCATGTACTCAACACAGT
GGGCAGCAGCCTGGGACGGCGTCCCCTCTCCCGGCGGCGGGCAAGCCTTGCGCTGCTCCACCCTCGGCCTGGGCACCCTCACTTGGCGCTGGCCACCTGG
GCCAGCCTGGGGCCATGGTCTCTCTGCAGCTGAGGCCCAGTGGCCCCTTGGGCAGTGATCGGCCCTCCCCGCATCACAGGGCCCTGGCAGCAAGCGGGAA
ATGGGGGCGCACACTGTGTGCTTGGGGGTGCTGCTTGTTTACCACACATGACCAGACTCCCAGCAGGACAGAGCTGCTCAGTACTTTACAGAAACCAACT
GAGTCGTTTGTGCATGAATTAAGCCGGTCTGCTTCCCCGTCACCTTCGTAACAAAACAACGTCCCCTCTCCCCTCGCCTCGAGCAGTTTCTTCAGGACAC
CGTGGCTCGGGCTGCTCCCTGCTGCCAGGCACGCTGGTTGGCTGGCCTGGGCCCGGCTCACGTGAAGGGCACTGGCTCTTGTGACCACACTGAGCCACGT
GCAAGCCGCAGCCGGGCCTGGAAGCCTGACCCTCTGGTTCTAGGGCTTGTCCCGCGGAGCCTGCAGAGCTAGACGTTGGGGTGTGTCCGTGATGATATGG
GGGCCAGGCTGGGAGTAGGGCCTTTCTAGCAGGGTTGGGTGGCTCAGTGAGGGTGTGGAAGTGGGGGACCCACGGGGCCTGGCTTTGGGACTAGACATGC
CAGCCCCAGCTGGGCTGGAGGGAGCCTGAGTGAGCCCCGACATACGCTGGGCCTTTCAGCTCGCCGTGCTCTGGTGACACACAGGCGGCCAGGTTGGGAT
TTGTGTCAATTCTAGGAGCCATCAAGCATGAATGTGGTTCTGTCTCCTGAGCGCAAGCCTCGCCGGACCCCTGGGCGAAGGCCTGGACTTGCAGATGTGT
GTTCCCTGTGCGGGTGGACAGAGGGGGCCCTTATGACCCACATTGCAGCCCCATTCCACCACCCCTTCCTCCCCAGAGCAGTCTCTGCCGAGGGACAGCA
CCTGTGTCCCTTCGATGCCACAACAGCCAGTTGAACAGGGGAGCCCTTTGCTCAGGCAGCTTCTCCTGCCTCTCCCTCCTTTCTCCTTCCCTGCCCCATC
CCCGTGCCCTTCTTGGCCTGTGGCGCTGGGGAGCCATGGTGTGGCATACTGGGGCTCCTGCTCCTTGGGCCACTTCCTCAGCCCGGGCCCCACAGGCCCA
CCACCTGCCAGGGCTCCCACTGCACTGGCTGTGGCAGGAGGCTTCCCCATGACCCCGTGTGGCCCAGCTCGGTGAGGATGCAGTTCTAGGCACAGCCCCT
GGGACAGCCAGCTGCCTCCCAGACCACGTCAGCCTGCTCCAGGGTCCTCAGTCACCCTGGGCCAGGGGCCACGTGTCCCATGGATGTCGACCATGCCAAC
GTCACATTCCAGCACCCCTTTTGCTTGATGGCGTCTGGTGGTAGTCAGCATGGTGGACCCACATCCTACAGCCAGAGGTGATGTTGGACAAAGGAAGGGG
AGTCTGGATGGGTCCTTAAACGACCATTCTGTCCGCAGCGGGGTCATTCCTTGTCAGCCCAAGGGAGGGCCGGGGAGTACACTGATCCCAACAGCTGGGC
TGACACCTCCTTTCTCCCCTGCACGGGGAGGATTGGCCTGAGGACCGTCACCCTGTGCACAGCCCCAGTAGGGTGGCAGTGCCACTGTCTCCTTGGGCCG
TTGCAGGATTGGGCGGGTGCAGACTCCCCTTGCGGGCCCCTTGCTCAATCCCCGGCCCTCCCAGACTCCTCCCTCTACTGGGGGTAATTTGTGTGTCAGA
AGGGCTCTGGCAGAGCTGTAAAATACTGTTTTTTAAAAATTTTAGTCCAGATCTTTACTTATTAGACTGCAGAAGGAGAGCTAGGGAGAGTGGGGGAAGC
CCCCTTGCTTTTGTATCTGTGAGGTGAATGAGGGTCTGTCACCCAAATCTACTTCTCAGCCCATGACCATAGTTCTGTTTTCCGTTTGCAAATCTCAGTA
GCTCTGTTTTCTCCAAAGTAGAATGTGCGCACCGGGGTCCTAGCCAGGCGAGGTCAGTGTCGGCAGGCTACCTGGTCATTATTGCTGCCTCGTCCAGGCT
GATGCTGATGGTCACAGGCACGGTGGCATCAGGGAGCCGGGCCAGCAGGCGGCGTGAGGCGGGGCCAGCAGCTCACTGCAAGGGCATTTTCCACCTGATC
CTGGTGTGCCCCACATGCGGTGGCAGGGCAGACGTGTGAAGCCTCGGCCGTCTCGGGGCTGGCAGGTGTGCGGGTGAGGAGGCCCCGGTGGCCAAGCAGA
GCCTGCGTTTCATTTCTCCTGCTGCACTGTGTCTAGTCTGTCTTGTGAACTCTCACCGTGAAAAGAGGCTAGAAGTCCAGGATCGCTGTACCGCTCCTGT
AATTAGGTGATGACTGGATTTGACAACTTAGTCCCCTCAGACAAGTAAGATACCCTCCAACAGCAAATTCAATGACTTAATTGGAAAACACACAAGCTGG
CATGATGTCCGGTGATTTCTGTAAGAAATGCCTGTAGGAGAAGGTCTGTGAAGTGTGGAGGGCAGTGTCGACGCTGCACAGCATCTGCAGATTCGCAGCC
TCTTCTCTGCCGGTGCCTCTGTTCGGTTCTGTTACCCAAAAACAAAGACCAAAGAAGGCCAATCTCTCATTTGACCCTGTCTTTTTAATCTGCCTGTTTT
AAAAGTTGCGTCTGTAGTAGCCGCTTGCTGTGAAGACACATCTTGACAGTCCAAGTGATTTTGTGACCAGTGATTTGGGTCCTGTTTTCCGCTCTTCTAA
GAAAAAACAAAAAGACCGTGAGTTATTGCCCAGCAATAATCATGTTGTTACTGTGAGTTAGCAACATGCCTGACTTCCTGATAGCATTACTGTTTTCTAG
TTTTGTTTATTGTATATTATGTGTGGTTTTATTTGGTATTTATTTGTGTTTTGAGGTCTTGCAATGTTTTTGTGTTTCTGATGCTAATAACTAAAGTTTG
TAAGACTGTAGAATGCAAAACTCGGAGATGCTAAACTGTCTTATTAGAGGAAAATAAATCTGATTATGGAGTCTCA
- TRAF3.u.f.1 (forward primer)
- TRAF3.u.r.3 (reverse primer)
- Single exon skipping
Frame 0
GSAARPPRARAGVAAQPGLSSRRQPRRPPALPRPPPWGSPGSRTLRTAAEDAPGAPEPAERRRTAR*
GK*GPKK*CHLVKVPEQVRIRPRIRNLAPGSWL
PTLLRIAVLTEENSSFLKWSRVKRWTLLARCRL
TRR*SCTLTAVLGRQFLSLNKEVTRKSL*RPWRT
STSVRSATWCCAARSRPSVGTASARAAWRPC*A
LQVQNVQRVKRASLKIRCLRIIAAREKFWLFRS
IVGMKAEVVQSS*CWDICWCI*KMIAILKNFHVC
VLTAKKRS*GKTCETTWRRRVNTGKPHAATARV
RFR*SRCRNTKTPTVPAWWCPALTSAASRLS*G
AS*VHTCQSVSMPPAPVVLSAMAAFFRGQTSRSR
PTRPAPPCSTSTC*RSGATRSKRRFPCCRMKV*
KKTRAYKVCTIRYVALKLKLRDKRKCFEIMNPK
SFIYSE**TAKQRN*RSLTRRSGPSGRTGRKQTA
*RAAWSPSRTA*PSWRAWTRARGKWLGTQACWS
PS*AGMTRC*VCTTSA*PTWTCASRSWRPPATM
ECSSGRFATTSGGSRRPSWGRPCPFTASLSTLVT
LAIRCVPGST*TGTGWGRGRTCRCFLSSCVENM
MPCFLGRLSRK*HSC*WIRGPLDVIWEMHSSPT
PTAAASRSPLER*ISPLAAQSLWPKLF*KMGHIL
KMIQFLLKS*WILRICPIPDK*LGRWI*QKATP
LGDLNRSVFTEVLALRKGPCETEEAAEGGRVPA
GGATREHT*HVL**TSHTSL*RIIYPSTR*ILLS
EKVFIFIFKDLVN*GGKHIC*TKET*FFFLKLE
HQKNTHTHTRGDSWTCQHVK*KENL*NSNAILI
SSF*NSRVQFCFKYSILSIFKASSGLCFNNLFVR
RP*SIYLGLFFESL*IQNHFLI*SSTNNCYCKH
FILKR**TDISWKKI*NIKHWLSLVIGKRIFNL
LLFLVRNVNLQISVVVNDTTSQF*TEPRSWMLCI
IFRFIIVFTLK*GIR*TLEF*TKSCRCLDSAPC
VRTSSLLLTAPAFGLHVRGGRVTAEGGPQVCFS
IPSSCCMPSTVSESNVVRRAGGIRPTCLRWDMLL
LHPGFALSIILESASLTRLFSPPLDLCLYKGPQ
TPLHLLRGSQAPPSASGASAA*LPQIPNL*APR
VSRLVQVRPGPTLREAGVEQKPSLSVSPPGPWAP
PQPEAEPSEHSRDRCSGACPG*PTGAPDHHPGG
KGGHGARRPSLCLPRWHFLNSLFTVSQCPTVIR
SLEPAPCTPFAMHHASWCSYH*WVLHATGAS*AK
PMCANCHTCATRPQAAPTIGQLGRARQTACLGS
PRGRAGTAWWVPGGPPVSGAAICPGCAFAPVPA
GSALRRTPVP*APVRGPPRPFAVEAFRCSYLPFL
SPLSWDYFGGMSILGSAL*GSRVSLLIKEGLPA
EAAENYCSLEGVPHLRPVPYLPSGSFPEARG*Q
QGHPCNFPFTKCIILDEGYATSWSSKNRFLPSGL
KSWCGPQKQQCVSLGRLQ*PFPGRRSWRDAMGP
T*GSHRRNLSDRSP*GWDGLCHTLCP*T*VMGV
LEDGMACVTRFVFVFGCIGVSVLSVSSSHVLNTV
GSSLGRRPLSRRRASLALLHPRPGHPHLALATW
ASLGPWSLCS*GPVAPWAVIGPPRITGPWQQAG
NGGAHCVLGGAACLPHMTRLPAGQSCSVLYRNQL
SRLCMN*AGLLPRHLRNKTTSPLPSPRAVSSGH
RGSGCSLLPGTLVGWPGPGSREGHWLL*PH*AT
CKPQPGLEA*PSGSRACPAEPAELDVGVCP**YG
GQAGSRAFLAGLGGSVRVWKWGTHGAWLWD*TC
QPQLGWREPE*APTYAGPFSSPCSGDTQAARLG
FVSILGAIKHECGSVS*AQASPDPWAKAWTCRCV
FPVRVDRGGPYDPHCSPIPPPLPPQSSLCRGTA
PVSLRCHNSQLNRGALCSGSFSCLSLLSPSLPH
PRALLGLWRWGAMVWHTGAPAPWATSSARAPQAH
HLPGLPLHWLWQEASP*PRVAQLGEDAVLGTAP
GTASCLPDHVSLLQGPQSPWARGHVSHGCRPCQ
RHIPAPLLLDGVWW*SAWWTHILQPEVMLDKGRG
VWMGP*TTILSAAGSFLVSPREGRGVH*SQQLG
*HLLSPLHGEDWPEDRHPVHSPSRVAVPLSPWA
VAGLGGCRLPLRAPCSIPGPPRLLPLLGVICVSE
GLWQSCKILFFKNFSPDLYLLDCRRRARESGGS
PLAFVSVR*MRVCHPNLLLSP*P*FCFPFANLS
SSVFSKVECAHRGPSQARSVSAGYLVIIAASSRL
MLMVTGTVASGSRASRRREAGPAAHCKGIFHLI
LVCPTCGGRADV*SLGRLGAGRCAGEEAPVAKQ
SLRFISPAALCLVCLVNSHREKRLEVQDRCTAPV
IR**LDLTT*SPQTSKIPSNSKFNDLIGKHTSW
HDVR*FL*EMPVGEGL*SVEGSVDAAQHLQIRS
LFSAGASVRFCYPKTKTKEGQSLI*PCLFNLPVL
KVASVVAACCEDTS*QSK*FCDQ*FGSCFPLF*
EKTKRP*VIAQQ*SCCYCELATCLTS**HYCFL
VLFIVYYVWFYLVFICVLRSCNVFVFLMLITKVC
KTVECKTRRC*TVLLEENKSDYGVS
Frame 1
GARRGRRVREPGLQPSRDFPAGGSRGGRRLFPAPRHGAARGAERCGPRRRTRPAPLSRPSGDGPRD
EENEAQRSDATWLRSQSRSESDLGSETWLLAPGS
LLF*GSLS*QKRTPLS*NGVE*KDGLSWRAAD*
PAAKAAH*PQCWDASFCP*TRRLQGKVCEDRGG
QVQV*EVPPGAVQPEADRVWAPLLRELHGGPAEL
FKSKMYSVSREHR*R*GV*G*LLQERNSGSSDL
LSE*KQRLCRAVNAGTSAGAFKK*LPF*RTSMC
AS*LQRKGLEERPARPRGEGV*IPGSHMQPLQES
GSDDRAAETRRHRLSLRGGVLPSQVQRPDSPEE
RVECTLVRVCQCPQHL*F*ALWLRFSGDKPADQ
GPRGQLRRAARQPAEGVEQLARKEGFLVAE*KCR
KKQEHTKFAQSDM*L*N*N*ETKGNASK**IQN
PSFTASDRQPSRETEGA*QGDPALPAELGGSRQ
HEEQRGVPPEPRDRAGERGQERGASGSEHRPAGV
PAEPA*PDAECARHPPSRHGPALPGPGDRQLQW
SAHLEDSRLQAAEAGGRHGEDPVPLQPAFLHWL
LWL*DVCQGLPERGRDGEGDALVAVFCHHAWRI*
CPASLAV*AESDTHADGSGVLSTSFGRCIQARP
QQQQLQEAHWRDEYRLWLPSLCGPNCSRKWDIY
*R*YNFY*SHSGYFGSARSLISSWGGGFSRRQLL
WGI*TGLSSLRSSRSEKDLVRRRKRQKADACRR
EEPRVSTPDTFYNRLATLHSEELFILQQDKYCC
QRRFSFSFLKI*LIKVENIYAKQKKHDFSSLNLN
TKKTHTHTHVGIAGHVSMLSKRRIYEIVMQF*Y
LLSKIQECNFVSNTVYCLFLRPHLVSVLIICLS
EDPEVYT*VFFLKVSKFRIIF*FKVLQIIVTANI
LF*NVDRLIFLGRKYKISNTGYHL**EREYSTC
CYFSLEM*TFKYLS*LMTRLHNSERSLAHGCCA
SFSDL*LFSP*NRASVELWSSKQNPVGVWILPHV
FGRALCC*QHRPSVSMSGVGG*LLREARRCVSP
SRHLAACRQRSPKATLCVELVAYGPRALDGTCC
FSTLGLH*ASF*KVLV*PDFSLHH*IFVSTRALR
HLCTC*GEARLHRRLLEPPLLNYHRFQISRPHE
*AAWSKYGLVPP*GRQVWNRSRASPCPHRGRGH
PHSPKQNPLSIPETAARGPAQADQRALLTTTLAG
RVATGPVVPACACPDGIFSTHCLLSLSVQL*LE
AWSLPPAPLLLCTTLHGALTTDGCYTRRVLLRQ
NQCVRTVTPVPLAHKPRPQLASWAVHVRLPASAL
PVAARGQLGGCPVAHLSLVLPSVLGVPSPQCLL
EVPSVAPLCPELP*GARRALSRSKRSVVLICLS
FPRSPGITLGE*VSLVLPCEGVVCPCS*RKDFLQ
KLRKTTVPSKVSPT*GLSPTCPQVVFLRPGVNN
RDIPATSPSQNV*Y*MKDMQHLGLVRTVSSPLG
*SPGVAPRSSSACHWDVSSSPSQADAPGGTPWGP
PEGPTDVT*VTGVLEDGMAYVTHFVLEPE*WGS
LRMGWPVSRALSLCLVVSGSLF*VCLPLMYSTQ
WAAAWDGVPSPGGGQALRCSTLGLGTLTWRWPPG
PAWGHGLSAAEAQWPLGQ*SALPASQGPGSKRE
MGAHTVCLGVLLVYHT*PDSQQDRAAQYFTETN
*VVCA*IKPVCFPVTFVTKQRPLSPRLEQFLQDT
VARAAPCCQARWLAGLGPAHVKGTGSCDHTEPR
ASRSRAWKPDPLVLGLVPRSLQS*TLGCVRDDM
GARLGVGPF*QGWVAQ*GCGSGGPTGPGFGTRHA
SPSWAGGSLSEPRHTLGLSARRALVTHRRPGWD
LCQF*EPSSMNVVLSPERKPRRTPGRRPGLADV
CSLCGWTEGALMTHIAAPFHHPFLPRAVSAEGQH
LCPFDATTAS*TGEPFAQAASPASPSFLLPCPI
PVPFLACGAGEPWCGILGLLLLGPLPQPGPHRP
TTCQGSHCTGCGRRLPHDPVWPSSVRMQF*AQPL
GQPAASQTTSACSRVLSHPGPGATCPMDVDHAN
VTFQHPFCLMASGGSQHGGPTSYSQR*CWTKEG
ESGWVLKRPFCPQRGHSLSAQGRAGEYTDPNSWA
DTSFLPCTGRIGLRTVTLCTAPVGWQCHCLLGP
LQDWAGADSPCGPLAQSPALPDSSLYWG*FVCQ
KGSGRAVKYCFLKILVQIFTY*TAEGELGRVGEA
PLLLYL*GE*GSVTQIYFSAHDHSSVFRLQISV
ALFSPK*NVRTGVLARRGQCRQATWSLLLPRPG
*C*WSQARWHQGAGPAGGVRRGQQLTARAFST*S
WCAPHAVAGQTCEASAVSGLAGVRVRRPRWPSR
ACVSFLLLHCV*SVL*TLTVKRG*KSRIAVPLL
*LGDDWI*QLSPLRQVRYPPTANSMT*LENTQAG
MMSGDFCKKCL*EKVCEVWRAVSTLHSICRFAA
SSLPVPLFGSVTQKQRPKKANLSFDPVFLICLF
*KLRL**PLAVKTHLDSPSDFVTSDLGPVFRSSK
KKQKDRELLPSNNHVVTVS*QHA*LPDSITVF*
FCLLYIMCGFIWYLFVF*GLAMFLCF*C**LKF
VRL*NAKLGDAKLSY*RKINLIMES
Frame 2
ERGAAAACASRGCSPAGTFQPAAAAAAAGSSPPPAMGQPGEQNAADRGGGRARRP*AGRAATDREM
RKMRPKEVMPLG*GPRAGQNQT*DQKPGSWLLA
PYSSKDRCPDRRELLFPKMESSKKMDSPGALQTN
PPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVED
KYKCEKCHLVLCSPKQTECGHRFCESCMAALLS
SSSPKCTACQESIVKDKVFKDNCCKREILALQIY
CRNESRGCAEQLMLGHLLVHLKNDCHFEELPCV
RPDCKEKVLRKDLRDHVEKACKYREATCSHCKS
QVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRS
ELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIK
AHEASSAVQHVNLLKEWSNSLEKKVSLLQNESV
EKNKSIQSLHNQICSFEIEIERQKEMLRNNESKI
LHLQRVIDSQAEKLKELDKEIRPFRQNWEEADS
MKSSVESLQNRVTELESVDKSAGQVARNTGLLE
SQLSRHDQMLSVHDIRLADMDLRFQVLETASYNG
VLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGY
FGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEY
DALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDP
NSSSFKKPTGEMNIASGCPVFVAQTVLENGTYI
KDDTIFIKVIVDTSDLPDP**VAGEVDLAEGNS
SGGFEPVCLH*GPRAQKRTL*DGGSGRRRTRAGG
RSHA*AHLTRFIID*PHFTLKNYLSFNKINIAV
REGFHFHF*RSS*LRWKTYMLNKRNMIFLP*T*
TPKKHTHTHTWG*LDMSAC*VKGEFMK**CNSDI
FFLKFKSAILFQIQYIVYF*GLIWSLF**FVCQ
KTLKYIPRSFF*KSLNSESFFNLKFYK*LLLQT
FYFKTLID*YFLEENIKYQTLVITCDRKENIQPV
VISR*KCKPSNICRS**HDFTILNGASLMDAVH
HFQIYNCFHPKIGHPLNFGVLNKIL*VFGFCPM
CSDELSVADSTGLRSPCQGWAGDC*GRPAGVFLH
PVILLHAVNGLRKQRCA*SWWHTAHVP*MGHAA
SPPWVCIEHHSRKC*FNQTFLSTTRSLSLQGPS
DTSAPAEGKPGSTVGFWSLRCLITTDSKSLGPTS
EPPGPSTAWSHPEGGRCGTEAEPLRVPTGAVGT
PTARSRTL*AFQRPLLGGLPRLTNGRS*PPPWR
EGWPRGPSSQPVPAQMAFSQLTVYCLSVSNCD*K
PGACPLHPFCYAPRFMVLLPLMGATRDGCFLGK
TNVCELSHLCHSPTSRAHNWPAGPCTSDCLPRL
SPWPRGDSLVGARWPTCLWCCHLSWVCLRPSACW
KCPPSHPCALSSREGPAAPFRGRSVPLFLSAFP
FPALLGLLWGNEYPWFCPVRESCVPAHKGRTSC
RSCGKLLFPRRCPPPEACPLPALR*FS*GQGLTT
GTSLQLPLHKMYNIR*RICNILV**EPFPPLWV
EVLVWPPEAAVRVTGTSPVALPRQTLLAGRHGA
HLRVPQT*PE*QESLRMGWPMSHTLSLNLSDGGP
*GWDGLCHALCLCVWLYRGLCSECVFLSCTQHS
GQQPGTASPLPAAGKPCAAPPSAWAPSLGAGHL
GQPGAMVSLQLRPSGPLGSDRPSPHHRALAASGK
WGRTLCAWGCCLFTTHDQTPSRTELLSTLQKPT
ESFVHELSRSASPSPS*QNNVPSPLASSSFFRT
PWLGLLPAARHAGWLAWARLT*RALALVTTLSHV
QAAAGPGSLTLWF*GLSRGACRARRWGVSVMIW
GPGWE*GLSSRVGWLSEGVEVGDPRGLALGLDM
PAPAGLEGA*VSPDIRWAFQLAVLW*HTGGQVGI
CVNSRSHQA*MWFCLLSASLAGPLGEGLDLQMC
VPCAGGQRGPL*PTLQPHSTTPSSPEQSLPRDS
TCVPSMPQQPVEQGSPLLRQLLLPLPPFSFPAPS
PCPSWPVALGSHGVAYWGSCSLGHFLSPGPTGP
PPARAPTALAVAGGFPMTPCGPAR*GCSSRHSP
WDSQLPPRPRQPAPGSSVTLGQGPRVPWMSTMPT
SHSSTPFA*WRLVVVSMVDPHPTARGDVGQRKG
SLDGSLNDHSVRSGVIPCQPKGGPGSTLIPTAG
LTPPFSPARGGLA*GPSPCAQPQ*GGSATVSLGR
CRIGRVQTPLAGPLLNPRPSQTPPSTGGNLCVR
RALAEL*NTVF*KF*SRSLLIRLQKES*GEWGK
PPCFCICEVNEGLSPKSTSQPMTIVLFSVCKSQ*
LCFLQSRMCAPGS*PGEVSVGRLPGHYCCLVQA
DADGHRHGGIREPGQQAA*GGASSSLQGHFPPD
PGVPHMRWQGRRVKPRPSRGWQVCG*GGPGGQAE
PAFHFSCCTVSSLSCELSP*KEARSPGSLYRSC
N*VMTGFDNLVPSDK*DTLQQQIQ*LNWKTHKL
A*CPVISVRNACRRRSVKCGGQCRRCTASADSQP
LLCRCLCSVLLPKNKDQRRPISHLTLSF*SACF
KSCVCSSRLL*RHILTVQVIL*PVIWVLFSALL
RKNKKTVSYCPAIIMLLL*VSNMPDFLIALLFSS
FVYCILCVVLFGIYLCFEVLQCFCVSDANN*SL
*DCRMQNSEMLNCLIRGK*I*LWSL
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