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Sequences

Sequence RTN4.hAug05

AGTCCCTGCCCTCCCCTGGGGAGGGTGAGTCACGCCAAACTGGGCGGAGAGTCCGCTGGCCTCACTCCTAGCTCATCTGGGCGGCGGCGGCAAGTGGGGA CAGGGCGGGTGGCGCATCACCGGCGCGGAGGCAGGAGGAGCAGTCTCATTGTTCCGGGAGCCGTCACCACAGTAGGTCCCTCGGCTCAGTCGGCCCAGCC CCTCTCAGTCCTCCCCAACCCCCACAACCGCCCGCGGCTCTGAGACGCGGCCCCGGCGGCGGCGGCAGCAGCTGCAGCATCATCTCCACCCTCCAGCCAT GGAAGACCTGGACCAGTCTCCTCTGGTCTCGTCCTCGGACAGCCCACCCCGGCCGCAGCCCGCGTTCAAGTACCAGTTCGTGAGGGAGCCCGAGGACGAG GAGGAAGAAGAGGAGGAGGAAGAGGAGGACGAGGACGAAGACCTGGAGGAGCTGGAGGTGCTGGAGAGGAAGCCCGCCGCCGGGCTGTCCGCGGCCCCAG TGCCCACCGCCCCTGCCGCCGGCGCGCCCCTGATGGACTTCGGAAATGACTTCGTGCCGCCGGCGCCCCGGGGACCCCTGCCGGCCGCTCCCCCCGTCGC CCCGGAGCGGCAGCCGTCTTGGGACCCGAGCCCGGTGTCGTCGACCGTGCCCGCGCCATCCCCGCTGTCTGCTGCCGCAGTCTCGCCCTCCAAGCTCCCT GAGGACGACGAGCCTCCGGCCCGGCCTCCCCCTCCTCCCCCGGCCAGCGTGAGCCCCCAGGCAGAGCCCGTGTGGACCCCGCCAGCCCCGGCTCCCGCCG CGCCCCCCTCCACCCCGGCCGCGCCCAAGCGCAGGGGCTCCTCGGGCTCAGTGGATGAGACCCTTTTTGCTCTTCCTGCTGCATCTGAGCCTGTGATACG CTCCTCTGCAGTTGTTGACCTCCTGTACTGGAGAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTC AGCATTGTGAGCGTAACAGCCTACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAG ATGAAGGCCACCCATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTG CACGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTG TTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGATAGATCATTATCTAGGAC TTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGG AGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGAT CTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAA ACCGTAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAG TTGCAGAGATGGTGGAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAA ATGTTTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATT GCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTGATATTTCAGAGTCAGT CATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCACACACATA GAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGC AAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTG TGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTTAAAATATGCTT

RTN4.u.f.6 (forward primer)
RTN4.au.5.r (reverse primer)
Single exon skipping

Frame 0

SPCPPLGRVSHAKLGGESAGLTPSSSGRRRQVG TGRVAHHRRGGRRSSLIVPGAVTTVGPSAQSAQP LSVLPNPHNRPRL*DAAPAAAAAAAASSPPSSH GRPGPVSSGLVLGQPTPAAARVQVPVREGARGR GGRRGGGRGGRGRRPGGAGGAGEEARRRAVRGPS AHRPCRRRAPDGLRK*LRAAGAPGTPAGRSPRR PGAAAVLGPEPGVVDRARAIPAVCCRSLALQAP *GRRASGPASPSSPGQREPPGRARVDPASPGSRR APLHPGRAQAQGLLGLSG*DPFCSSCCI*ACDT LLCSC*PPVLERH*EDWSGVWCQPIPAAFIDSI QHCERNSLHCLGPALCDHQL*DIQGCDPSYPEIR *RPPIQGISGI*SCYI*GVGSEVQ*FCSWSCEL HDKGTQAPLLS**FS*FSEVCSVDVGIYLCWCL V*WSDTTDFGSHFTLQCSCYL*TASGTDRSLSRT CK*EC*RCYG*NPSKNPWIEAQS*MKTPKIISR SSSLKGIFI*LYGGGSGKNEP*RCSAVSQIVVR SLFLAMHCCEEKLPVLTAMCSSS*VL*AAMYGFK P*SYLFPIYLRHWWNKKPVYFTLLQIVLPHLGK LQRWWS*KKKKKSPFQFVHCVWSV*IDADFLK* NVCLDEIIPVKQE*QSLLFWYVLGVL*LLLLY*L PI*VNIDYICIVFHKA*TFTFQPPHSA*YFRVS HWLYMCSSKAHKLEEEIFLGALPSVFNMKCHTH RTPTSISLHRLTVVNFVTESMD*I*CFQKCCLFA NIKHCYARNY*LQNEDLYHCGLSCTELNLWNAL *TVKAKYQ*SL*T*NML

Frame 1

VPALPWGG*VTPNWAESPLASLLAHLGGGGKWG QGGWRITGAEAGGAVSLFREPSPQ*VPRLSRPS PSQSSPTPTTARGSETRPRRRRQQLQHHLHPPAM EDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDE EEEEEEEEEDEDEDLEELEVLERKPAAGLSAAP VPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVA PERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLP EDDEPPARPPPPPPASVSPQAEPVWTPPAPAPA APPSTPAAPKRRGSSGSVDETLFALPAASEPVIR SSAVVDLLYWRDIKKTGVVFGASLFLLLSLTVF SIVSVTAYIALALLSVTISFRIYKGVIQAIQKS DEGHPFRAYLESEVAISEELVQKYSNSALGHVNC TIKELRRLFLVDDLVDSLKFAVLMWVFTYVGAL FNGLTLLILALISLFSVPVIYERHQAQIDHYLG LANKNVKDAMAKIQAKIPGLKRKAE*KRPK*LVG VHL*RGYSFDYTGEGQGRTNLDVAVQFHRSLLD LYF*PCTVVRKNYLS*LPCVHHLKYCKLLCMDL NRNHIFFLSI*GTGGIKNLYILLCCR*SCRILAS CRDGGARKKKKKALFSLCTVYGPCRLMQIF*NE MFV*TRSYR*SRNDKACFSGMF*VYCDFYCYIN CQYK*I*IIYV*CFTKLRPLPSSHPTVLDISESV IGYTCVVPKHIS*KKKYF*EHYHLFST*NATHI ELQHQFHCTD*L*LILSQNLWTESNASKNVVCL QISNIVMQEIINYKMKIYTIVV*AVLN*ICGMHC EL*KQSINKAYRLKIC

Frame 2

SLPSPGEGESRQTGRRVRWPHS*LIWAAAASGD RAGGASPARRQEEQSHCSGSRHHSRSLGSVGPA PLSPPQPPQPPAALRRGPGGGGSSCSIISTLQP WKTWTSLLWSRPRTAHPGRSPRSSTSS*GSPRTR RKKRRRKRRTRTKTWRSWRCWRGSPPPGCPRPQ CPPPLPPARP*WTSEMTSCRRRPGDPCRPLPPS PRSGSRLGTRARCRRPCPRHPRCLLPQSRPPSSL RTTSLRPGLPLLPRPA*APRQSPCGPRQPRLPP RPPPPRPRPSAGAPRAQWMRPFLLFLLHLSL*Y APLQLLTSCTGETLRRLEWCLVPAYSCCFH*QYS AL*A*QPTLPWPCSL*PSALGYTRV*SKLSRNQ MKATHSGHIWNLKLLYLRSWFRSTVILLLVM*T AR*RNSGASS*LMI*LIL*SLQC*CGYLPMLVPC LMV*HY*FWLSFHSSVFLLFMNGIRHR*III*D LQIRMLKMLWLKSKQKSLD*SAKLNENAQNN** EFIFKGDIHLIIRGRVREERTLTLQCSFTDRC*I FIFSHALL*GKITCLDCHVFIILSIVSCYVWI* TVIISFSYLSEALVE*KTCIFYFVADSLAASWQ VAEMVELEKKKKKPFSVCALCMVRVD*CRFSEMK CLFRRDHTGKAGMTKLAFLVCSRCIVTFTVILI ANISKYRLYMYSVSQSLDLYLPATPQCLIFQSQ SLVIHV*FQST*ARRRNISRSTTICFQHEMPHT* NSNINFIAQTDCS*FCHRIYGLNLMLPKMLFVC KYQTLLCKKLLITK*RFIPLWFKLY*TKSVECI VNCKSKVSIKLIDLKYA

Sequence RTN4.aAug05

AGTCCCTGCCCTCCCCTGGGGAGGGTGAGTCACGCCAAACTGGGCGGAGAGTCCGCTGGCCTCACTCCTAGCTCATCTGGGCGGCGGCGGCAAGTGGGGA CAGGGCGGGTGGCGCATCACCGGCGCGGAGGCAGGAGGAGCAGTCTCATTGTTCCGGGAGCCGTCACCACAGTAGGTCCCTCGGCTCAGTCGGCCCAGCC CCTCTCAGTCCTCCCCAACCCCCACAACCGCCCGCGGCTCTGAGACGCGGCCCCGGCGGCGGCGGCAGCAGCTGCAGCATCATCTCCACCCTCCAGCCAT GGAAGACCTGGACCAGTCTCCTCTGGTCTCGTCCTCGGACAGCCCACCCCGGCCGCAGCCCGCGTTCAAGTACCAGTTCGTGAGGGAGCCCGAGGACGAG GAGGAAGAAGAGGAGGAGGAAGAGGAGGACGAGGACGAAGACCTGGAGGAGCTGGAGGTGCTGGAGAGGAAGCCCGCCGCCGGGCTGTCCGCGGCCCCAG TGCCCACCGCCCCTGCCGCCGGCGCGCCCCTGATGGACTTCGGAAATGACTTCGTGCCGCCGGCGCCCCGGGGACCCCTGCCGGCCGCTCCCCCCGTCGC CCCGGAGCGGCAGCCGTCTTGGGACCCGAGCCCGGTGTCGTCGACCGTGCCCGCGCCATCCCCGCTGTCTGCTGCCGCAGTCTCGCCCTCCAAGCTCCCT GAGGACGACGAGCCTCCGGCCCGGCCTCCCCCTCCTCCCCCGGCCAGCGTGAGCCCCCAGGCAGAGCCCGTGTGGACCCCGCCAGCCCCGGCTCCCGCCG CGCCCCCCTCCACCCCGGCCGCGCCCAAGCGCAGGGGCTCCTCGGGCTCAGTGGATGAGACCCTTTTTGCTCTTCCTGCTGCATCTGAGCCTGTGATACG CTCCTCTGCAGAAAATATGGACTTGAAGGAGCAGCCAGGTAACACTATTTCGGCTGGTCAAGAGGATTTCCCATCTGTCCTGCTTGAAACTGCTGCTTCT CTTCCTTCTCTGTCTCCTCTCTCAGCCGCTTCTTTCAAAGAACATGAATACCTTGGTAATTTGTCAACAGTATTACCCACTGAAGGAACACTTCAAGAAA ATGTCAGTGAAGCTTCTAAAGAGGTCTCAGAGAAGGCAAAAACTCTACTCATAGATAGAGATTTAACAGAGTTTTCAGAATTAGAATACTCAGAAATGGG ATCATCGTTCAGTGTCTCTCCAAAAGCAGAATCTGCCGTAATAGTAGCAAATCCTAGGGAAGAAATAATCGTGAAAAATAAAGATGAAGAAGAGAAGTTA GTTAGTAATAACATCCTTCATAATCAACAAGAGTTACCTACAGCTCTTACTAAATTGGTTAAAGAGGATGAAGTTGTGTCTTCAGAAAAAGCAAAAGACA GTTTTAATGAAAAGAGAGTTGCAGTGGAAGCTCCTATGAGGGAGGAATATGCAGACTTCAAACCATTTGAGCGAGTATGGGAAGTGAAAGATAGTAAGGA AGATAGTGATATGTTGGCTGCTGGAGGTAAAATCGAGAGCAACTTGGAAAGTAAAGTGGATAAAAAATGTTTTGCAGATAGCCTTGAGCAAACTAATCAC GAAAAAGATAGTGAGAGTAGTAATGATGATACTTCTTTCCCCAGTACGCCAGAAGGTATAAAGGATCGTTCAGGAGCATATATCACATGTGCTCCCTTTA ACCCAGCAGCAACTGAGAGCATTGCAACAAACATTTTTCCTTTGTTAGGAGATCCTACTTCAGAAAATAAGACCGATGAAAAAAAAATAGAAGAAAAGAA GGCCCAAATAGTAACAGAGAAGAATACTAGCACCAAAACATCAAACCCTTTTCTTGTAGCAGCACAGGATTCTGAGACAGATTATGTCACAACAGATAAT TTAACAAAGGTGACTGAGGAAGTCGTGGCAAACATGCCTGAAGGCCTGACTCCAGATTTAGTACAGGAAGCATGTGAAAGTGAATTGAATGAAGTTACTG GTACAAAGATTGCTTATGAAACAAAAATGGACTTGGTTCAAACATCAGAAGTTATGCAAGAGTCACTCTATCCTGCAGCACAGCTTTGCCCATCATTTGA AGAGTCAGAAGCTACTCCTTCACCAGTTTTGCCTGACATTGTTATGGAAGCACCATTGAATTCTGCAGTTCCTAGTGCTGGTGCTTCCGTGATACAGCCC AGCTCATCACCATTAGAAGCTTCTTCAGTTAATTATGAAAGCATAAAACATGAGCCTGAAAACCCCCCACCATATGAAGAGGCCATGAGTGTATCACTAA AAAAAGTATCAGGAATAAAGGAAGAAATTAAAGAGCCTGAAAATATTAATGCAGCTCTTCAAGAAACAGAAGCTCCTTATATATCTATTGCATGTGATTT AATTAAAGAAACAAAGCTTTCTGCTGAACCAGCTCCGGATTTCTCTGATTATTCAGAAATGGCAAAAGTTGAACAGCCAGTGCCTGATCATTCTGAGCTA GTTGAAGATTCCTCACCTGATTCTGAACCAGTTGACTTATTTAGTGATGATTCAATACCTGACGTTCCACAAAAACAAGATGAAACTGTGATGCTTGTGA AAGAAAGTCTCACTGAGACTTCATTTGAGTCAATGATAGAATATGAAAATAAGGAAAAACTCAGTGCTTTGCCACCTGAGGGAGGAAAGCCATATTTGGA ATCTTTTAAGCTCAGTTTAGATAACACAAAAGATACCCTGTTACCTGATGAAGTTTCAACATTGAGCAAAAAGGAGAAAATTCCTTTGCAGATGGAGGAG CTCAGTACTGCAGTTTATTCAAATGATGACTTATTTATTTCTAAGGAAGCACAGATAAGAGAAACTGAAACGTTTTCAGATTCATCTCCAATTGAAATTA TAGATGAGTTCCCTACATTGATCAGTTCTAAAACTGATTCATTTTCTAAATTAGCCAGGGAATATACTGACCTAGAAGTATCCCACAAAAGTGAAATTGC TAATGCCCCGGATGGAGCTGGGTCATTGCCTTGCACAGAATTGCCCCATGACCTTTCTTTGAAGAACATACAACCCAAAGTTGAAGAGAAAATCAGTTTC TCAGATGACTTTTCTAAAAATGGGTCTGCTACATCAAAGGTGCTCTTATTGCCTCCAGATGTTTCTGCTTTGGCCACTCAAGCAGAGATAGAGAGCATAG TTAAACCCAAAGTTCTTGTGAAAGAAGCTGAGAAAAAACTTCCTTCCGATACAGAAAAAGAGGACAGATCACCATCTGCTATATTTTCAGCAGAGCTGAG TAAAACTTCAGTTGTTGACCTCCTGTACTGGAGAGACATTAAGAAGACTGGAGTGGTGTTTGGTGCCAGCCTATTCCTGCTGCTTTCATTGACAGTATTC AGCATTGTGAGCGTAACAGCCTACATTGCCTTGGCCCTGCTCTCTGTGACCATCAGCTTTAGGATATACAAGGGTGTGATCCAAGCTATCCAGAAATCAG ATGAAGGCCACCCATTCAGGGCATATCTGGAATCTGAAGTTGCTATATCTGAGGAGTTGGTTCAGAAGTACAGTAATTCTGCTCTTGGTCATGTGAACTG CACGATAAAGGAACTCAGGCGCCTCTTCTTAGTTGATGATTTAGTTGATTCTCTGAAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTG TTTAATGGTCTGACACTACTGATTTTGGCTCTCATTTCACTCTTCAGTGTTCCTGTTATTTATGAACGGCATCAGGCACAGATAGATCATTATCTAGGAC TTGCAAATAAGAATGTTAAAGATGCTATGGCTAAAATCCAAGCAAAAATCCCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGG AGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGAT CTTTATTTTTAGCCATGCACTGTTGTGAGGAAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAA ACCGTAATCATATCTTTTTCCTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAG TTGCAGAGATGGTGGAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAA ATGTTTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATATTAATT GCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTGATATTTCAGAGTCAGT CATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGTTTTCAACATGAAATGCCACACACATA GAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGC AAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTG TGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTTAAAATATGCTT

RTN4.u.f.6 (forward primer)
RTN4.au.5.r (reverse primer)
Single exon skipping

Frame 0

SPCPPLGRVSHAKLGGESAGLTPSSSGRRRQVG TGRVAHHRRGGRRSSLIVPGAVTTVGPSAQSAQP LSVLPNPHNRPRL*DAAPAAAAAAAASSPPSSH GRPGPVSSGLVLGQPTPAAARVQVPVREGARGR GGRRGGGRGGRGRRPGGAGGAGEEARRRAVRGPS AHRPCRRRAPDGLRK*LRAAGAPGTPAGRSPRR PGAAAVLGPEPGVVDRARAIPAVCCRSLALQAP *GRRASGPASPSSPGQREPPGRARVDPASPGSRR APLHPGRAQAQGLLGLSG*DPFCSSCCI*ACDT LLCRKYGLEGAAR*HYFGWSRGFPICPA*NCCF SSFSVSSLSRFFQRT*IPW*FVNSITH*RNTSRK CQ*SF*RGLREGKNSTHR*RFNRVFRIRILRNG IIVQCLSKSRICRNSSKS*GRNNREK*R*RREV S***HPS*STRVTYSSY*IG*RG*SCVFRKSKRQ F**KESCSGSSYEGGICRLQTI*ASMGSER**G R**YVGCWR*NREQLGK*SG*KMFCR*P*AN*S RKR**E****YFFPQYARRYKGSFRSIYHMCSL* PSSN*EHCNKHFSFVRRSYFRK*DR*KKNRRKE GPNSNREEY*HQNIKPFSCSSTGF*DRLCHNR* FNKGD*GSRGKHA*RPDSRFSTGSM*K*IE*SYW YKDCL*NKNGLGSNIRSYARVTLSCSTALPII* RVRSYSFTSFA*HCYGSTIEFCSS*CWCFRDTA QLITIRSFFS*L*KHKT*A*KPPTI*RGHECITK KSIRNKGRN*RA*KY*CSSSRNRSSLYIYCM*F N*RNKAFC*TSSGFL*LFRNGKS*TASA*SF*A S*RFLT*F*TS*LI***FNT*RSTKTR*NCDACE RKSH*DFI*VNDRI*K*GKTQCFAT*GRKAIFG IF*AQFR*HKRYPVT**SFNIEQKGENSFADGG AQYCSLFK**LIYF*GSTDKRN*NVFRFISN*NY R*VPYIDQF*N*FIF*ISQGIY*PRSIPQK*NC *CPGWSWVIALHRIAP*PFFEEHTTQS*RENQF LR*LF*KWVCYIKGALIASRCFCFGHSSRDREHS *TQSSCERS*EKTSFRYRKRGQITICYIFSRAE *NFSC*PPVLERH*EDWSGVWCQPIPAAFIDSI QHCERNSLHCLGPALCDHQL*DIQGCDPSYPEIR *RPPIQGISGI*SCYI*GVGSEVQ*FCSWSCEL HDKGTQAPLLS**FS*FSEVCSVDVGIYLCWCL V*WSDTTDFGSHFTLQCSCYL*TASGTDRSLSRT CK*EC*RCYG*NPSKNPWIEAQS*MKTPKIISR SSSLKGIFI*LYGGGSGKNEP*RCSAVSQIVVR SLFLAMHCCEEKLPVLTAMCSSS*VL*AAMYGFK P*SYLFPIYLRHWWNKKPVYFTLLQIVLPHLGK LQRWWS*KKKKKSPFQFVHCVWSV*IDADFLK* NVCLDEIIPVKQE*QSLLFWYVLGVL*LLLLY*L PI*VNIDYICIVFHKA*TFTFQPPHSA*YFRVS HWLYMCSSKAHKLEEEIFLGALPSVFNMKCHTH RTPTSISLHRLTVVNFVTESMD*I*CFQKCCLFA NIKHCYARNY*LQNEDLYHCGLSCTELNLWNAL *TVKAKYQ*SL*T*NML

Frame 1

VPALPWGG*VTPNWAESPLASLLAHLGGGGKWG QGGWRITGAEAGGAVSLFREPSPQ*VPRLSRPS PSQSSPTPTTARGSETRPRRRRQQLQHHLHPPAM EDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDE EEEEEEEEEDEDEDLEELEVLERKPAAGLSAAP VPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVA PERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLP EDDEPPARPPPPPPASVSPQAEPVWTPPAPAPA APPSTPAAPKRRGSSGSVDETLFALPAASEPVIR SSAENMDLKEQPGNTISAGQEDFPSVLLETAAS LPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQE NVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMG SSFSVSPKAESAVIVANPREEIIVKNKDEEEKL VSNNILHNQQELPTALTKLVKEDEVVSSEKAKD SFNEKRVAVEAPMREEYADFKPFERVWEVKDSKE DSDMLAAGGKIESNLESKVDKKCFADSLEQTNH EKDSESSNDDTSFPSTPEGIKDRSGAYITCAPF NPAATESIATNIFPLLGDPTSENKTDEKKIEEKK AQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDN LTKVTEEVVANMPEGLTPDLVQEACESELNEVT GTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFE ESEATPSPVLPDIVMEAPLNSAVPSAGASVIQP SSSPLEASSVNYESIKHEPENPPPYEEAMSVSL KKVSGIKEEIKEPENINAALQETEAPYISIACDL IKETKLSAEPAPDFSDYSEMAKVEQPVPDHSEL VEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLV KESLTETSFESMIEYENKEKLSALPPEGGKPYLE SFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEE LSTAVYSNDDLFISKEAQIRETETFSDSSPIEI IDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIA NAPDGAGSLPCTELPHDLSLKNIQPKVEEKISF SDDFSKNGSATSKVLLLPPDVSALATQAEIESI VKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELS KTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVF SIVSVTAYIALALLSVTISFRIYKGVIQAIQKS DEGHPFRAYLESEVAISEELVQKYSNSALGHVNC TIKELRRLFLVDDLVDSLKFAVLMWVFTYVGAL FNGLTLLILALISLFSVPVIYERHQAQIDHYLG LANKNVKDAMAKIQAKIPGLKRKAE*KRPK*LVG VHL*RGYSFDYTGEGQGRTNLDVAVQFHRSLLD LYF*PCTVVRKNYLS*LPCVHHLKYCKLLCMDL NRNHIFFLSI*GTGGIKNLYILLCCR*SCRILAS CRDGGARKKKKKALFSLCTVYGPCRLMQIF*NE MFV*TRSYR*SRNDKACFSGMF*VYCDFYCYIN CQYK*I*IIYV*CFTKLRPLPSSHPTVLDISESV IGYTCVVPKHIS*KKKYF*EHYHLFST*NATHI ELQHQFHCTD*L*LILSQNLWTESNASKNVVCL QISNIVMQEIINYKMKIYTIVV*AVLN*ICGMHC EL*KQSINKAYRLKIC

Frame 2

SLPSPGEGESRQTGRRVRWPHS*LIWAAAASGD RAGGASPARRQEEQSHCSGSRHHSRSLGSVGPA PLSPPQPPQPPAALRRGPGGGGSSCSIISTLQP WKTWTSLLWSRPRTAHPGRSPRSSTSS*GSPRTR RKKRRRKRRTRTKTWRSWRCWRGSPPPGCPRPQ CPPPLPPARP*WTSEMTSCRRRPGDPCRPLPPS PRSGSRLGTRARCRRPCPRHPRCLLPQSRPPSSL RTTSLRPGLPLLPRPA*APRQSPCGPRQPRLPP RPPPPRPRPSAGAPRAQWMRPFLLFLLHLSL*Y APLQKIWT*RSSQVTLFRLVKRISHLSCLKLLLL FLLCLLSQPLLSKNMNTLVICQQYYPLKEHFKK MSVKLLKRSQRRQKLYS*IEI*QSFQN*NTQKW DHRSVSLQKQNLP***QILGKK*S*KIKMKKRS* LVITSFIINKSYLQLLLNWLKRMKLCLQKKQKT VLMKRELQWKLL*GRNMQTSNHLSEYGK*KIVR KIVICWLLEVKSRATWKVKWIKNVLQIALSKLIT KKIVRVVMMILLSPVRQKV*RIVQEHISHVLPL TQQQLRALQQTFFLC*EILLQKIRPMKKK*KKR RPK**QRRILAPKHQTLFL*QHRILRQIMSQQII *QR*LRKSWQTCLKA*LQI*YRKHVKVN*MKLL VQRLLMKQKWTWFKHQKLCKSHSILQHSFAHHL KSQKLLLHQFCLTLLWKHH*ILQFLVLVLP*YSP AHHH*KLLQLIMKA*NMSLKTPHHMKRP*VYH* KKYQE*RKKLKSLKILMQLFKKQKLLIYLLHVI *LKKQSFLLNQLRISLIIQKWQKLNSQCLIILS* LKIPHLILNQLTYLVMIQYLTFHKNKMKL*CL* KKVSLRLHLSQ**NMKIRKNSVLCHLREESHIW NLLSSV*ITQKIPCYLMKFQH*AKRRKFLCRWRS SVLQFIQMMTYLFLRKHR*EKLKRFQIHLQLKL *MSSLH*SVLKLIHFLN*PGNILT*KYPTKVKL LMPRMELGHCLAQNCPMTFL*RTYNPKLKRKSVS QMTFLKMGLLHQRCSYCLQMFLLWPLKQR*RA* LNPKFL*KKLRKNFLPIQKKRTDHHLLYFQQS* VKLQLLTSCTGETLRRLEWCLVPAYSCCFH*QYS AL*A*QPTLPWPCSL*PSALGYTRV*SKLSRNQ MKATHSGHIWNLKLLYLRSWFRSTVILLLVM*T AR*RNSGASS*LMI*LIL*SLQC*CGYLPMLVPC LMV*HY*FWLSFHSSVFLLFMNGIRHR*III*D LQIRMLKMLWLKSKQKSLD*SAKLNENAQNN** EFIFKGDIHLIIRGRVREERTLTLQCSFTDRC*I FIFSHALL*GKITCLDCHVFIILSIVSCYVWI* TVIISFSYLSEALVE*KTCIFYFVADSLAASWQ VAEMVELEKKKKKPFSVCALCMVRVD*CRFSEMK CLFRRDHTGKAGMTKLAFLVCSRCIVTFTVILI ANISKYRLYMYSVSQSLDLYLPATPQCLIFQSQ SLVIHV*FQST*ARRRNISRSTTICFQHEMPHT* NSNINFIAQTDCS*FCHRIYGLNLMLPKMLFVC KYQTLLCKKLLITK*RFIPLWFKLY*TKSVECI VNCKSKVSIKLIDLKYA