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Sequences

Sequence CASP9.dAug05

primer-113212 (forward primer)
primer-113213 (reverse primer)
Multiple exon skipping

Frame 0

Frame 1

Frame 2

Sequence CASP9.aAug05

GACGCAGTGGTGGATTCTGGAGCGGGGCGGTGACGTGGGGCGGGTTCTGGGGCGGGGCGGTGACGCGGAGCGTGTTCTGGGGCGGCGCGGTGATGGGAGG CTTGGCCCTGGGGGCGGGGCGAGGCGCAGAGGTGCGTCCTGAGGGCGGGGCGGTGACGCAAGAGCGACTCCTGGGGGCGGGGCGAGGCCTTGGAGATGCG TCCGGAGGCGGTGGGGAGCGAAGACTGACCCGGGGCCGTGACGCGGGGGCAGGCCCTGGGGCGGGGGCGGGTCCTGGGGACTGGGGCGGGCGGCCGAGGC CCGGAAGCGGACTGAGGCGGCCTGGAGTCTTAGTTGGCTACTCGCCATGGACGAAGCGGATCGGCGGCTCCTGCGGCGGTGCCGGCTGCGGCTGGTGGAA GAGCTGCAGGTGGACCAGCTCTGGGACGCCCTGCTGAGCCGCGAGCTGTTCAGGCCCCATATGATCGAGGACATCCAGCGGGCAGGCTCTGGATCTCGGC GGGATCAGGCCAGGCAGCTGATCATAGATCTGGAGACTCGAGGGAGTCAGGCTCTTCCTTTGTTCATCTCCTGCTTAGAGGACACAGGCCAGGACATGCT GGCTTCGTTTCTGCGAACTAACAGGCAAGCAGCAAAGTTGTCGAAGCCAACCCTAGAAAACCTTACCCCAGTGGTGCTCAGACCAGAGATTCGCAAACCA GAGGTTCTCAGACCGGAAACACCCAGACCAGTGGACATTGGTTCTGGAGGATTTGGTGATGTCGGTGCTCTTGAGAGTTTGAGGGGAAATGCAGATTTGG CTTACATCCTGAGCATGGAGCCCTGTGGCCACTGCCTCATTATCAACAATGTGAACTTCTGCCGTGAGTCCGGGCTCCGCACCCGCACTGGCTCCAACAT CGACTGTGAGAAGTTGCGGCGTCGCTTCTCCTCGCTGCATTTCATGGTGGAGGTGAAGGGCGACCTGACTGCCAAGAAAATGGTGCTGGCTTTGCTGGAG CTGGCGCAGCAGGACCACGGTGCTCTGGACTGCTGCGTGGTGGTCATTCTCTCTCACGGCTGTCAGGCCAGCCACCTGCAGTTCCCAGGGGCTGTCTACG GCACAGATGGATGCCCTGTGTCGGTCGAGAAGATTGTGAACATCTTCAATGGGACCAGCTGCCCCAGCCTGGGAGGGAAGCCCAAGCTCTTTTTCATCCA GGCCTGTGGTGGGGAGCAGAAAGACCATGGGTTTGAGGTGGCCTCCACTTCCCCTGAAGACGAGTCCCCTGGCAGTAACCCCGAGCCAGATGCCACCCCG TTCCAGGAAGGTTTGAGGACCTTCGACCAGCTGGACGCCATATCTAGTTTGCCCACACCCAGTGACATCTTTGTGTCCTACTCTACTTTCCCAGGTTTTG TTTCCTGGAGGGACCCCAAGAGTGGCTCCTGGTACGTTGAGACCCTGGACGACATCTTTGAGCAGTGGGCTCACTCTGAAGACCTGCAGTCCCTCCTGCT TAGGGTGAGTGCTGCCTTCCTCTGCAAAGGAGAGGGGAGGCTGCTGAGGGGCAGCGTGTCCTCCTGGGGCTGGGGATTTGGGGTGAGCAGGGCAGGCCCA AACCAAGGGTAAAAGGTAGTAGACTCCTGCCTCTGAGCCTTGGAGTCGGCACTTTTGTGTCTCTTTATGAGAGGCATCCTGCCTGTGGTGACGTTTGCCC TTTATTCAAAGAGTTGCCTTCCCTGTCTCCTCCAAGGTCCCCAGGTTGACACCTCCCGCTCCTCCACTGATGGAGCTGGTCCTCAGTGCCAGCGCAGGAT GGCTCTGTCCAGACCCTGAAGGCGGGTCATGGGCCCCTCCCTATATCCTGTGGGCATCATGTAGTCTTCTACTCTTGACCCTCAAGAATTGTGAACCCCT CCTTGTACATCGCCTTCTCAGGAGGCCCCAGTGAGGAAACAGATAGGGAAGGGTGGCCTGATAGGCCCAGTCCTACTCCATAGAAACCCGACTCAGAGCA GTTGCTTCCTCTGAGGGTCCTGTGGCCTTGTGGCTGCCTTGGGAGGCAGCATGTATGGGCCCCAGCTGCTCTGCTCAGGTATTCATGCCACGAGAAGGGG CTGCGAGGCTGGGGCCACTCCTGGCTCCTTGCAAATATTTCAGTCTGATTTGAACTTTATGAATTTGGAAATTTTGAATTTTGAGTTTTTTAAAGGTAAA GTTGAGGTGCGTATTCTTTAAGCCCTCCTGCTCAAAGAGGCTGCAGTTTGAGCTGTTTTTAAGGTGCGGGTTGAGTGGACATTCCCCCCAGCCCCTCTTG AATTCTTCCTTCAGTCCAGAGAACTGAACTCACAGAGCTCTCCATGGTCATGTCTTACAGGTCGCTAATGCTGTTTCGGTGAAAGGGATTTATAAACAGA TGCCTGGTTGCTTTAATTTCCTCCGGAAAAAACTTTTCTTTAAAACATCATAAGGCCAGGGCCCCTCACCCTGCCTTATCTTGCACCCCAAAGCTTTCCT GCCCCAGGCCTGAAAGAGGCTGAGGCCTGGACTTTCCTGCAACTCAAGGACTTTGCAGCCGGCACAGGGTCTGCTCTTTCTCTGCCAGTGACAGACAGGC TCTTAGCAGCTTCCAGATTGACGACAAGTGCTGAACAGTGGAGGAAGAGGGACAGATGAATGCCGTGGATTGCACGTGGCCTCTTGAGCAGTGGCTGGTC CAGGGCTAGTGACTTGTGTCCCATGATCCCTGTGTTGTCTCTAGAGCAGGGATTAACCTCTGCACTACTGACATGTGGGGCCAGGTCACCCTTTGCTGTG AGGCTGTCCTGTACATTGTGGGATGTTCAGCACTGTCCCTTGCCTCAATGCCAGTAACGCGTCTTCCTGAGTGGTGCCAAACAAAAAGGTTCTCAGGTGT TGCCAAATATGTCCTGGGGTATAAAACTTTCCTCGCCTGACAACCACTGGTCTGTAGGGATTTTTGGCTACACACAAACCAGTATCGCTCATAGATCAGC AAACCGGGGCCTACTAGAGTCTGAACAGCTGTAATCTATGAATTCTAAGTGAAATTTTAAAAATTGTTAATTTTTCCTATATTGCATTAATTTTAAAAAA TAAATCTGAGGCAAATATGGACTCTCTTTTGCCTATTTCTTCCCTCATTTTGCTCCAACTCTTTCTTCTTCCTTACAAAAGAGACTTTTGCTTTTTTCGA AACATTTCCCCATGTTTTTCTGGGGTCTCGCTATGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAAGTGACCCTCCCAAGTAGCTCTTACTACAGGCG TGCACCATTGCACCCAGCCCCATTTATTCATGTCTTATTTCACTTGATCCTTATCCCATCCCAGGAAGGCAACAAGGGTGAGAACCCTGTGCTCAGGGAG GTTAGGTCTCTTGTCCAAGGGAAAACGATTATCCAGAGAAGAGACCTGGCCAGAACCTGGGTCCCCTGAGTCCTAGCCATGCTTCCCATGTGCCTTACTT GCTGAAGCACCCCCGGACTGCAGTGTGAACGTGCTGTGCAATAGTGACACGCTGGGCTTCCCCACAAGGCTCCACCCTGAGGTCTTTTAAGCTGTCCTTA TGCCAGCCTATTTCTTGTTTTTTGGGCCTTTTTTTTTGGAGATAGGGTCTCACTCTGTCGCCCAGGCTGGAGTGCAATGACGCAATCTTGGCTTATTGCA GTCTCGACCTCCTGGGCTCAAGAGATCCTTCCACCTCAGCCACCTGAGTAGCTTGGACTACAGGTGTGCACCACCTCTCCCAGTTAATTTTTGTATTTTT AGTAGAGACAGAGTTATGCCATGTTACTCAGGCTGGTCTTGAACTCCTGGACTCAAGCGATCAGCCTGCCTTAGCCTCCCAAAGTGCAGGGGTTACAGGC TTGAGCCATTGCGCCTGACCTATTTCTGGTTCTTAGGGCCCTGGATGTTAGGATGGATTTCTGAATTAATAATAATAATAAAACCCTCATCAAGATGTGA TTTGCATAGTTGTCACTTTATATAATATTATTTTCCTTCTGTGACCTTTCCAAGTCTGAAACAGTCCCAGGGACTTCTTTTGGTTAGTTATTTGCAATCA CCTGCAGGACACACACACAAGAAAATTGTCAGGTTCACGTAACCACAGAGCTGTGCGTGGCAGTTTCCTGTCTCTGTCCTCCTGGGCTAAGCTACTCAAG TGAGTCACAGGCAGCCCACACTACAGTAGCTCCTGCCTGAGGAGTTCAGATGATGTTTCGGAGAAAAAGATGCAATCACAGCTTTTCATTGACCTGTTAG GGTCTTCCTGTAAAGGGGGTCTTAGCCAGGAGTCCTGTGTGGGCTTCAGGTCAGGGGGCCTTCGAACCCCCTAAAAATTATATGCCAAATGTGCGGATGG CATATTTTTAGATTTCATTTGTTTCTCATCAAAACTGCTGTTTGCAAGGCAGTTATGCACTGTGGTTGGGGCTATAACTGTTTCCAGAGGCTGTTGATCA GTATCTGTTAAACTTTTTTTTTTTTTTTTTGAGACAGTCTTGCTCTGTTGCCCAGACGAGTACAGTGAGCTGAGATCAAGCCACTGTACTCCAGCCTGTG CAACAGAGCGAGACTCCATTTGAAAAAAAACAAAACAAAAACAATGATTACCTCTGGAGAGTGGAATTGGAGATGTAAAATGAGGGGGGACTTCTACTTT TTTACTTGATACTCTCCTGTATTCTTTTAATATTTTTACAAAGAGTATGTATTACCTTCTGGAAAAAGAATAAAAACTAAGGATTGCTGGAGTTCATGTG TGACTGTCATTCAACTGACATTTGTTGAAAGGATGAATGCCGCAGGCCACTTGTCTCCTCTGCTTCTCTGCTCTTATCTTTTGCTTGTACTTCCTGACCT TGGCTTGTCACCTGTCTGGGTTTATCCAGGCAGGTGCTCTCAGTCACCCCCAGGGCTCTAGTGGTACGTGACTCCAGGCTGCACACACTGTGTCCCTGGG TTGGGGCCACTTCAAGGTTTCACTAGCCCCTCTGCCGCTGCCAGGGGCAGCCCCCACCCAAGGACAGCTGGTTGCTTGGCTCTCCCCCTTCTGAAACCCG TTACCGGGCATCTGTGCCTGTCCCGACTGCTCTCCCATGAACACAGGGCCTCTGCCCAGCTGCCTCGGGAGGCGTGCTGCCCCGTGGATCCCTGCTGCCA TCTGGCCATGCTTTGGGATCTGGCCTGTTCTGTTGTGCTTGTGTCTGTGGCTGGGAACAGCTGATGCTGGGAACAGCTGATGCTGGGACAACAGATCGGG ACAATTGCCCCTGCCCCTGCTTCAGGTCCCCAGGATGCTGCCAGGACCAGCTGCACGGTGACTCCCACAGCAGCTGGGGCTGGAAAACGGTCTTAGGATT TGGCTGGGAAAGGCCCCTAAGCAGCCTTTCGTCCAGTCAGTCTCAGGCCAGGCTCCTTTGACGTGCGTGGTGCCTCCAAAGGTGGACTCAGATGGGTTTT TCCCAATTTAGATATAAAAAGCCCCAATTAATGATTAATGGCTACTGTCTTTTTGATTTTCCATTTTTTTCCAACAAACTTTTTTGGAATTTCTGCCTAT GACCACTTGTTGGCAAAAGGATGCCAGCAGACAGACAAATGAACAAGGAGCTGGCAAGAATCAATGGGAACACTTGGAAGCAGCCACCTGCTTATTTTGA CAGTTTAGTTTTCTCCCCTGACCACGTGCTTATGGCTGCAGTTTCATATTTGGTTTTATAAGTGTCAGTTTAATTCAATTTAACACTTCTCTGCAAATTA AACTTAGTGAAGTCAGATGTCAGCTTTCCCCTTCTTTGGGGGCTCTGCCACGAATACCATAACTCCCTCTTGCTCTAGTGCCTAAAAATGTGGAGGTCTA GTTCAAGTCCCACTTTACAGAAGAGCAAACAGGTGGTCCCTAATTGGCACAAAGTATCCGCCTCTTCTCCCCCAGCTTCTATTACCAGGCATGGTGTCTC CTCTGCCCTCTCCTGGGCTCCCCTTTCTTGTGACGGGGTTTCCTCTTCTGGCTGCTTTCATCTACTTCTGTGTGTATCCATGGCTGCTCCTTAATATTTA TGCCAACTATTATTATCATTATTTTCAGAGACAGGGTCTTGCTATGTCGCTCAGGCTGCAGTGCAGTGGTGCGACCTTGGCTTACTGTAGGCTCCACCTC TTGGGCCAAAGCGATCCTTCCACCTCAGCCTCCCAAGCAGCTGAGACTACAGGCATGCACCACCATGGCTAATT

primer-113212 (forward primer)
primer-113213 (reverse primer)
Multiple exon skipping

Frame 0

DAVVDSGAGR*RGAGSGAGR*RGACSGAAR*WE AWPWGRGEAQRCVLRAGR*RKSDSWGRGEALEMR PEAVGSED*PGAVTRGQALGRGRVLGTGAGGRG PEAD*GGLES*LATRHGRSGSAAPAAVPAAAGG RAAGGPALGRPAEPRAVQAPYDRGHPAGRLWISA GSGQAADHRSGDSRESGSSFVHLLLRGHRPGHA GFVSAN*QASSKVVEANPRKPYPSGAQTRDSQT RGSQTGNTQTSGHWFWRIW*CRCS*EFEGKCRFG LHPEHGALWPLPHYQQCELLP*VRAPHPHWLQH RL*EVAASLLLAAFHGGGEGRPDCQENGAGFAG AGAAGPRCSGLLRGGHSLSRLSGQPPAVPRGCLR HRWMPCVGREDCEHLQWDQLPQPGREAQALFHP GLWWGAERPWV*GGLHFP*RRVPWQ*PRARCHP VPGRFEDLRPAGRHI*FAHTQ*HLCVLLYFPRFC FLEGPQEWLLVR*DPGRHL*AVGSL*RPAVPPA *GECCLPLQRRGEAAEGQRVLLGLGIWGEQGRP KPRVKGSRLLPLSLGVGTFVSLYERHPACGDVCP LFKELPSLSPPRSPG*HLPLLH*WSWSSVPAQD GSVQTLKAGHGPLPISCGHHVVFYS*PSRIVNP SLYIAFSGGPSEETDREGWPDRPSPTP*KPDSEQ LLPLRVLWPCGCLGRQHVWAPAALLRYSCHEKG LRGWGHSWLLANISV*FELYEFGNFEF*VF*R* S*GAYSLSPPAQRGCSLSCF*GAG*VDIPPSPS* ILPSVQRTELTELSMVMSYRSLMLFR*KGFINR CLVALISSGKNFSLKHHKARAPHPALSCTPKLS CPRPERG*GLDFPATQGLCSRHRVCSFSASDRQA LSSFQIDDKC*TVEEEGQMNAVDCTWPLEQWLV QG**LVSHDPCVVSRAGINLCTTDMWGQVTLCC EAVLYIVGCSALSLASMPVTRLPEWCQTKRFSGV AKYVLGYKTFLA*QPLVCRDFWLHTNQYRS*IS KPGPTRV*TAVIYEF*VKF*KLLIFPILH*F*K INLRQIWTLFCLFLPSFCSNSFFFLTKETFAFFE TFPHVFLGSRYVAQAGLKLLGSSDPPK*LLLQA CTIAPSPIYSCLISLDPYPIPGRQQG*EPCAQG G*VSCPRENDYPEKRPGQNLGPLSPSHASHVPYL LKHPRTAV*TCCAIVTRWASPQGSTLRSFKLSL CQPISCFLGLFFWR*GLTLSPRLECNDAILAYC SLDLLGSRDPSTSAT*VAWTTGVHHLSQLIFVFL VETELCHVTQAGLELLDSSDQPALASQSAGVTG LSHCA*PISGS*GPGC*DGFLN*****NPHQDV ICIVVTLYNIIFLL*PFQV*NSPRDFFWLVICNH LQDTHTRKLSGSRNHRAVRGSFLSLSSWAKLLK *VTGSPHYSSSCLRSSDDVSEKKMQSQLFIDLL GSSCKGGLSQESCVGFRSGGLRTP*KLYAKCADG IFLDFICFSSKLLFARQLCTVVGAITVSRGC*S VSVKLFFFFFETVLLCCPDEYSELRSSHCTPAC ATERDSI*KKTKQKQ*LPLESGIGDVK*GGTSTF LLDTLLYSFNIFTKSMYYLLEKE*KLRIAGVHV *LSFN*HLLKG*MPQATCLLCFSALIFCLYFLT LACHLSGFIQAGALSHPQGSSGT*LQAAHTVSLG WGHFKVSLAPLPLPGAAPTQGQLVAWLSPF*NP LPGICACPDCSPMNTGPLPSCLGRRAAPWIPAA IWPCFGIWPVLLCLCLWLGTADAGNS*CWDNRSG QLPLPLLQVPRMLPGPAAR*LPQQLGLENGLRI WLGKAPKQPFVQSVSGQAPLTCVVPPKVDSDGF FPI*I*KAPIND*WLLSF*FSIFFQQTFLEFLPM TTCWQKDASRQTNEQGAGKNQWEHLEAATCLF* QFSFLP*PRAYGCSFIFGFISVSLIQFNTSLQI KLSEVRCQLSPSLGALPRIP*LPLALVPKNVEV* FKSHFTEEQTGGP*LAQSIRLFSPSFYYQAWCL LCPLLGSPFL*RGFLFWLLSSTSVCIHGCSLIF MPTIIIIIFRDRVLLCRSGCSAVVRPWLTVGSTS WAKAILPPQPPKQLRLQACTTMAN

Frame 1

TQWWILERGGDVGRVLGRGGDAERVLGRRGDGR LGPGGGARRRGAS*GRGGDARATPGGGARPWRC VRRRWGAKTDPGP*RGGRPWGGGGSWGLGRAAEA RKRTEAAWSLSWLLAMDEADRRLLRRCRLRLVE ELQVDQLWDALLSRELFRPHMIEDIQRAGSGSR RDQARQLIIDLETRGSQALPLFISCLEDTGQDML ASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKP EVLRPETPRPVDIGSGGFGDVGALESLRGNADL AYILSMEPCGHCLIINNVNFCRESGLRTRTGSNI DCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLE LAQQDHGALDCCVVVILSHGCQASHLQFPGAVY GTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQ ACGGEQKDHGFEVASTSPEDESPGSNPEPDATP FQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGF VSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLL RVSAAFLCKGEGRLLRGSVSSWGWGFGVSRAGP NQG*KVVDSCL*ALESALLCLFMRGILPVVTFA LYSKSCLPCLLQGPQVDTSRSSTDGAGPQCQRRM ALSRP*RRVMGPSLYPVGIM*SSTLDPQEL*TP PCTSPSQEAPVRKQIGKGGLIGPVLLHRNPTQS SCFL*GSCGLVAALGGSMYGPQLLCSGIHATRRG CEAGATPGSLQIFQSDLNFMNLEILNFEFFKGK VEVRIL*ALLLKEAAV*AVFKVRVEWTFPPAPL EFFLQSRELNSQSSPWSCLTGR*CCFGERDL*TD AWLL*FPPEKTFL*NIIRPGPLTLPYLAPQSFP APGLKEAEAWTFLQLKDFAAGTGSALSLPVTDR LLAASRLTTSAEQWRKRDR*MPWIARGLLSSGWS RASDLCPMIPVLSLEQGLTSALLTCGARSPFAV RLSCTLWDVQHCPLPQCQ*RVFLSGAKQKGSQV LPNMSWGIKLSSPDNHWSVGIFGYTQTSIAHRSA NRGLLESEQL*SMNSK*NFKNC*FFLYCINFKK *I*GKYGLSFAYFFPHFAPTLSSSLQKRLLLFS KHFPMFFWGLAMLPRLVSNSWAQVTLPSSSYYRR APLHPAPFIHVLFHLILIPSQEGNKGENPVLRE VRSLVQGKTIIQRRDLARTWVP*VLAMLPMCLT C*STPGLQCERAVQ**HAGLPHKAPP*GLLSCPY ASLFLVFWAFFFGDRVSLCRPGWSAMTQSWLIA VSTSWAQEILPPQPPE*LGLQVCTTSPS*FLYF **RQSYAMLLRLVLNSWTQAISLP*PPKVQGLQA *AIAPDLFLVLRALDVRMDF*INNNNKTLIKM* FA*LSLYIILFSFCDLSKSETVPGTSFG*LFAI TCRTHTQENCQVHVTTELCVAVSCLCPPGLSYSS ESQAAHTTVAPA*GVQMMFRRKRCNHSFSLTC* GLPVKGVLARSPVWASGQGAFEPPKNYMPNVRM AYF*ISFVSHQNCCLQGSYALWLGL*LFPEAVDQ YLLNFFFFFLRQSCSVAQTSTVS*DQATVLQPV QQSETPFEKKQNKNNDYLWRVELEM*NEGGLLL FYLILSCILLIFLQRVCITFWKKNKN*GLLEFMC DCHSTDIC*KDECRRPLVSSASLLLSFACTS*P WLVTCLGLSRQVLSVTPRALVVRDSRLHTLCPW VGATSRFH*PLCRCQGQPPPKDSWLLGSPPSETR YRASVPVPTALP*TQGLCPAASGGVLPRGSLLP SGHALGSGLFCCACVCGWEQLMLGTADAGTTDR DNCPCPCFRSPGCCQDQLHGDSHSSWGWKTVLGF GWERPLSSLSSSQSQARLL*RAWCLQRWTQMGF SQFRYKKPQLMINGYCLFDFPFFSNKLFWNFCL *PLVGKRMPADRQMNKELARINGNTWKQPPAYFD SLVFSPDHVLMAAVSYLVL*VSV*FNLTLLCKL NLVKSDVSFPLLWGLCHEYHNSLLL*CLKMWRS SSSPTLQKSKQVVPNWHKVSASSPPASITRHGVS SALSWAPLSCDGVSSSGCFHLLLCVSMAAP*YL CQLLLSLFSETGSCYVAQAAVQWCDLGLL*APP LGPKRSFHLSLPSS*DYRHAPPWLI

Frame 2

RSGGFWSGAVTWGGFWGGAVTRSVFWGGAVMGG LALGAGRGAEVRPEGGAVTQERLLGAGRGLGDA SGGGGERRLTRGRDAGAGPGAGAGPGDWGGRPR PGSGLRRPGVLVGYSPWTKRIGGSCGGAGCGWWK SCRWTSSGTPC*AASCSGPI*SRTSSGQALDLG GIRPGS*S*IWRLEGVRLFLCSSPA*RTQARTC WLRFCELTGKQQSCRSQP*KTLPQWCSDQRFANQ RFSDRKHPDQWTLVLEDLVMSVLLRV*GEMQIW LTS*AWSPVATASLSTM*TSAVSPGSAPALAPT STVRSCGVASPRCISWWR*RAT*LPRKWCWLCWS WRSRTTVLWTAAWWSFSLTAVRPATCSSQGLST AQMDALCRSRRL*TSSMGPAAPAWEGSPSSFSS RPVVGSRKTMGLRWPPLPLKTSPLAVTPSQMPPR SRKV*GPSTSWTPYLVCPHPVTSLCPTLLSQVL FPGGTPRVAPGTLRPWTTSLSSGLTLKTCSPSC LG*VLPSSAKERGGC*GAACPPGAGDLG*AGQAQ TKGKR**TPASEPWSRHFCVSL*EASCLW*RLP FIQRVAFPVSSKVPRLTPPAPPLMELVLSASAG WLCPDPEGGSWAPPYILWASCSLLLLTLKNCEPL LVHRLLRRPQ*GNR*GRVA**AQSYSIETRLRA VASSEGPVALWLPWEAACMGPSCSAQVFMPREG AARLGPLLAPCKYFSLI*TL*IWKF*ILSFLKVK LRCVFFKPSCSKRLQFELFLRCGLSGHSPQPLL NSSFSPEN*THRALHGHVLQVANAVSVKGIYKQ MPGCFNFLRKKLFFKTS*GQGPSPCLILHPKAFL PQA*KRLRPGLSCNSRTLQPAQGLLFLCQ*QTG S*QLPD*RQVLNSGGRGTDECRGLHVAS*AVAG PGLVTCVP*SLCCL*SRD*PLHY*HVGPGHPLL* GCPVHCGMFSTVPCLNASNASS*VVPNKKVLRC CQICPGV*NFPRLTTTGL*GFLATHKPVSLIDQ QTGAY*SLNSCNL*ILSEILKIVNFSYIALILKN KSEANMDSLLPISSLILLQLFLLPYKRDFCFFR NISPCFSGVSLCCPGWSQTPGLK*PSQVALTTG VHHCTQPHLFMSYFT*SLSHPRKATRVRTLCSGR LGLLSKGKRLSREETWPEPGSPES*PCFPCALL AEAPPDCSVNVLCNSDTLGFPTRLHPEVF*AVL MPAYFLFFGPFFLEIGSHSVAQAGVQ*RNLGLLQ SRPPGLKRSFHLSHLSSLDYRCAPPLPVNFCIF SRDRVMPCYSGWS*TPGLKRSACLSLPKCRGYR LEPLRLTYFWFLGPWMLGWISELIIIIKPSSRCD LHSCHFI*YYFPSVTFPSLKQSQGLLLVSYLQS PAGHTHKKIVRFT*PQSCAWQFPVSVLLG*ATQ VSHRQPTLQ*LLPEEFR*CFGEKDAITAFH*PVR VFL*RGS*PGVLCGLQVRGPSNPLKIICQMCGW HIFRFHLFLIKTAVCKAVMHCGWGYNCFQRLLI SIC*TFFFFF*DSLALLPRRVQ*AEIKPLYSSLC NRARLHLKKNKTKTMITSGEWNWRCKMRGDFYF FT*YSPVFF*YFYKEYVLPSGKRIKTKDCWSSC VTVIQLTFVERMNAAGHLSPLLLCSYLLLVLPDL GLSPVWVYPGRCSQSPPGL*WYVTPGCTHCVPG LGPLQGFTSPSAAARGSPHPRTAGCLALPLLKP VTGHLCLSRLLSHEHRASAQLPREACCPVDPCCH LAMLWDLACSVVLVSVAGNS*CWEQLMLGQQIG TIAPAPASGPQDAARTSCTVTPTAAGAGKRS*D LAGKGP*AAFRPVSLRPGSFDVRGASKGGLRWVF PNLDIKSPN**LMATVFLIFHFFPTNFFGISAY DHLLAKGCQQTDK*TRSWQESMGTLGSSHLLIL TV*FSPLTTCLWLQFHIWFYKCQFNSI*HFSAN* T**SQMSAFPFFGGSATNTITPSCSSA*KCGGL VQVPLYRRANRWSLIGTKYPPLLPQLLLPGMVS PLPSPGLPFLVTGFPLLAAFIYFCVYPWLLLNIY ANYYYHYFQRQGLAMSLRLQCSGATLAYCRLHL LGQSDPSTSASQAAETTGMHHHG*

Sequence CASP9.bAug05

primer-113212 (forward primer)
primer-113213 (reverse primer)
Multiple exon skipping

Frame 0

Frame 1

Frame 2

Sequence CASP9.cAug05

GCGCGGAATGGATTCTGGGGTCGGCGCGAGGCGCTGAGCGGGCAGGCTCTGGATCTCGGCGGGATCAGGCCAGGCAGCTGATCATAGATCTGGAGACTCG AGGGAGTCAGGCTCTTCCTTTGTTCATCTCCTGCTTAGAGGACACAGGCCAGGACATGCTGGCTTCGTTTCTGCGAACTAACAGGCAAGCAGCAAAGTTG TCGAAGCCAACCCTAGAAAACCTTACCCCAGTGGTGCTCAGACCAGAGATTCGCAAACCAGAGGTTCTCAGACCGGAAACACCCAGACCAGTGGACATTG GTTCTGGAGGATTTGGTGATGTCGGTGCTCTTGAGAGTTTGAGGGGAAATGCAGATTTGGCTTACATCCTGAGCATGGAGCCCTGTGGCCACTGCCTCAT TATCAACAATGTGAACTTCTGCCGTGAGTCCGGGCTCCGCACCCGCACTGGCTCCAACATCGACTGTGAGAAGTTGCGGCGTCGCTTCTCCTCGCTGCAT TTCATGGTGGAGGTGAAGGGCGACCTGACTGCCAAGAAAATGGTGCTGGCTTTGCTGGAGCTGGCGCAGCAGGACCACGGTGCTCTGGACTGCTGCGTGG TGGTCATTCTCTCTCACGGCTGTCAGGCCAGCCACCTGCAGTTCCCAGGGGCTGTCTACGGCACAGATGGATGCCCTGTGTCGGTCGAGAAGATTGTGAA CATCTTCAATGGGACCAGCTGCCCCAGCCTGGGAGGGAAGCCCAAGCTCTTTTTCATCCAGGCCTGTGGTGGGGAGCAGAAAGACCATGGGTTTGAGGTG GCCTCCACTTCCCCTGAAGACGAGTCCCCTGGCAGTAACCCCGAGCCAGATGCCACCCCGTTCCAGGAAGGTTTGAGGACCTTCGACCAGCTGGACGCCA TATCTAGTTTGCCCACACCCAGTGACATCTTTGTGTCCTACTCTACTTTCCCAGGTTTTGTTTCCTGGAGGGACCCCAAGAGTGGCTCCTGGTACGTTGA GACCCTGGACGACATCTTTGAGCAGTGGGCTCACTCTGAAGACCTGCAGTCCCTCCTGCTTAGGGTCGCTAATGCTGTTTCGGTGAAAGGGATTTATAAA CAGATGCCTGGTTGCTTTAATTTCCTCCGGAAAAAACTTTTCTTTAAAACATCATAAGGCCAGGGCCCCTCACCCTGCCTTATCTTGCACCCCAAAGCTT TCCTGCCCCAGGCCTGAAAGAGGCTGAGGCCTGGACTTTCCTGCAACTCAAGGACTTTGCAGCCGGCACAGGGTCTGCTCTTTCTCTGCCAGTGACAGAC AGGCTCTTAGCAGCTTCCAGATTGACGACAAGTGCTGAACAGTGGAGGAAGAGGGACAGATGAATGCCGTGGATTGCACGTGGCCTCTTGAGCAGTGGCT GGTCCAGGGCTAGTGACTTGTGTCCCATGATCCCTGTGTTGTCTCTAGAGCAGGGATTAACCTCTGCACTACTGACATGTGGGGCCAGGTCACCCTTTGC TGTGAGGCTGTCCTGTACATTGTGGGATGTTCAGCACTGTCCCTTGCCTCAATGCCAGTAACGCGTCTTCCTGAGTGGTGCCAAACAAAAAGGTTCTCAG GTGTTGCCAAATATGTCCTGGGGTATAAAACTTTCCTCGCCTGACAACCACTGGTCTGTAGGGATTTTTGGCTACACACAAACCAGTATCGCTCATAGAT CAGCAAACCGGGGCCTACTAGAGTCTGAACAGCTGTAATCTATGAATTCTAAGTGAAATTTTAAAAATTGTTAATTTTTCCTATATTGCATTAATTTTAA AAAATAAATCTGAGGCAAATATGGACTCTCT

primer-113212 (forward primer)
primer-113213 (reverse primer)
Multiple exon skipping

Frame 0

ARNGFWGRREALSGQALDLGGIRPGS*S*IWRL EGVRLFLCSSPA*RTQARTCWLRFCELTGKQQSC RSQP*KTLPQWCSDQRFANQRFSDRKHPDQWTL VLEDLVMSVLLRV*GEMQIWLTS*AWSPVATAS LSTM*TSAVSPGSAPALAPTSTVRSCGVASPRCI SWWR*RAT*LPRKWCWLCWSWRSRTTVLWTAAW WSFSLTAVRPATCSSQGLSTAQMDALCRSRRL* TSSMGPAAPAWEGSPSSFSSRPVVGSRKTMGLRW PPLPLKTSPLAVTPSQMPPRSRKV*GPSTSWTP YLVCPHPVTSLCPTLLSQVLFPGGTPRVAPGTL RPWTTSLSSGLTLKTCSPSCLGSLMLFR*KGFIN RCLVALISSGKNFSLKHHKARAPHPALSCTPKL SCPRPERG*GLDFPATQGLCSRHRVCSFSASDR QALSSFQIDDKC*TVEEEGQMNAVDCTWPLEQWL VQG**LVSHDPCVVSRAGINLCTTDMWGQVTLC CEAVLYIVGCSALSLASMPVTRLPEWCQTKRFS GVAKYVLGYKTFLA*QPLVCRDFWLHTNQYRS*I SKPGPTRV*TAVIYEF*VKF*KLLIFPILH*F* KINLRQIWTL

Frame 1

RGMDSGVGARR*AGRLWISAGSGQAADHRSGDS RESGSSFVHLLLRGHRPGHAGFVSAN*QASSKV VEANPRKPYPSGAQTRDSQTRGSQTGNTQTSGHW FWRIW*CRCS*EFEGKCRFGLHPEHGALWPLPH YQQCELLP*VRAPHPHWLQHRL*EVAASLLLAA FHGGGEGRPDCQENGAGFAGAGAAGPRCSGLLRG GHSLSRLSGQPPAVPRGCLRHRWMPCVGREDCE HLQWDQLPQPGREAQALFHPGLWWGAERPWV*G GLHFP*RRVPWQ*PRARCHPVPGRFEDLRPAGRH I*FAHTQ*HLCVLLYFPRFCFLEGPQEWLLVR* DPGRHL*AVGSL*RPAVPPA*GR*CCFGERDL* TDAWLL*FPPEKTFL*NIIRPGPLTLPYLAPQSF PAPGLKEAEAWTFLQLKDFAAGTGSALSLPVTD RLLAASRLTTSAEQWRKRDR*MPWIARGLLSSG WSRASDLCPMIPVLSLEQGLTSALLTCGARSPFA VRLSCTLWDVQHCPLPQCQ*RVFLSGAKQKGSQ VLPNMSWGIKLSSPDNHWSVGIFGYTQTSIAHR SANRGLLESEQL*SMNSK*NFKNC*FFLYCINFK K*I*GKYGLS

Frame 2

AEWILGSARGAERAGSGSRRDQARQLIIDLETR GSQALPLFISCLEDTGQDMLASFLRTNRQAAKL SKPTLENLTPVVLRPEIRKPEVLRPETPRPVDI GSGGFGDVGALESLRGNADLAYILSMEPCGHCLI INNVNFCRESGLRTRTGSNIDCEKLRRRFSSLH FMVEVKGDLTAKKMVLALLELAQQDHGALDCCV VVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVN IFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEV ASTSPEDESPGSNPEPDATPFQEGLRTFDQLDA ISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVE TLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYK QMPGCFNFLRKKLFFKTS*GQGPSPCLILHPKA FLPQA*KRLRPGLSCNSRTLQPAQGLLFLCQ*QT GS*QLPD*RQVLNSGGRGTDECRGLHVAS*AVA GPGLVTCVP*SLCCL*SRD*PLHY*HVGPGHPL L*GCPVHCGMFSTVPCLNASNASS*VVPNKKVLR CCQICPGV*NFPRLTTTGL*GFLATHKPVSLID QQTGAY*SLNSCNL*ILSEILKIVNFSYIALIL KNKSEANMDS