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Sequences

Sequence SIVA.hAug05

SIVA_HUMAN-3 (forward primer)
SIVA_HUMAN-4 (reverse primer)
Single exon skipping

Frame 0

CDVTASLVRGWRPGSCVAPGPAAMPKRSCPFAD VAPLQLKVRVSQRELSRGVCAERYSQEVFDPSGV ASIACSSCVRAVDGKAVCGQCERALCGQCVRTC WGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET *GWLKPAAFTGSHAVHGSLPWTSARCSH*TVGST GGVPFTCSILYPNDRMNKPLYICTRG

Frame 1

VTSRRRW*GAGGRGAA*LPAPRPCPSGAAPSRT WPRYSSRSA*ARGS*AAACAPSATRRRSSTHLG *RPLPVPHACEPWMGRRSAVSVSEPCAGSVCAPA GAAAPWPVPCVASWTAVTCTRKCCAPAVPCSRP EAGSSRLPSPGATPCMAAFPGRALGVHTELWGR REGCLLHVLFCILMTE*INLFIFAQED

Frame 2

*RHGVVGKGLAAGELRSSRPRGHAQAELPLRGR GPATAQGPREPEGVEPRRVRRALLAGGLRPIWG SVHCLFLMRASRGWEGGLRSV*ASPVRAVCAHL LGLRLRGLYPVWPRGLQ*HVRESAVHQLCHVRDL RLAQAGCLHREPRRAWQPSLDERSVFTLNCGVD GRGAFYMFYFVS**QNE*TSLYLHKR

Sequence SIVA.fAug05

TGTGACGTCACGGCGTCGTTGGTAAGGGGCTGGCGGCCGGGGAGCTGCGTAGCTCCCGGCCCCGCGGCCATGCCCAAGCGGAGCTGCCCCTTCGCGGACG TGGCCCCGCTACAGCTCAAGGTCCGCGTGAGCCAGAGGGAGTTGAGCCGCGGCGTGTGCGCCGAGCGCTACTCGCAGGAGGTCTTCGAGAAGACCAAGCG ACTCCTGTTCCTCGGGGCCCAGGCCTACCTGGACCACGTGTGGGATGAAGGCTGTGCCGTCGTTCACCTGCCAGAGTCCCCAAAGCCTGGCCCTACAGGG GCCCCGAGGGCTGCACGTGGGCAGATGCTGATTGGACCAGACGGCCGCCTGATCAGGAGCCTTGGGCAGGCCTCCGAAGCTGACCCATCTGGGGTAGCGT CCATTGCCTGTTCCTCATGCGTGCGAGCCGTGGATGGGAAGGCGGTCTGCGGTCAGTGTGAGCGAGCCCTGTGCGGGCAGTGTGTGCGCACCTGCTGGGG CTGCGGCTCCGTGGCCTGTACCCTGTGTGGCCTCGTGGAGTAAGTACTTCAGTCCCTGGAGCTGCTGAGATCCCATAGCCCCAGCAAGCCGTGATGGGGG ACGGGTGGGTCACCCATGTGGGCCCAGAACACACACGTGTGGCCCCTGATGCAGTGCCATCTGGCATTGCCTAACGGGACATGGTGGCAATAGATGCTTG GCCCAACTTTAGTGGTTAGTAATCCTCTCTAAGGGAAAGCTGAACCTCACAGATGACCTGCTCTGTATCCGGCTCTAGTCCCTGTCTTCAGCCACTTCCT GTTCTGATCTTTGAGCACCCCCACCTCCTCCTCCTCTGGTCTTTGAGCCCCCCCTCCCCCCGTCCGAGGAGCCCCTGGTTGGTGACACAGGTGCACACCG CAGCTTCACCACAGTCATGCGTGCCGTTTGGTTGTAGACCCTCTCAGGCAGGAAGTGGAGTGTTTGTGTAGTCTCCCATTTGTGGGTGGGTTTGCTGCAG CTGGCTGGATCCCGTCCTTACTCCTAAGGTGGGGAGGGGCGTTCTCACCCTAGGGGCTACTCACCTGGTGGATGGGAGTGGACAGTGTGGAGCCTGTTTG CCCTGCCCCGTGAGAAAGATGACTTCATCCAGACACATGTGGAACTGGCTCCATAGACCCAAAGCAAGCTTAGTCCAAACAATGTCTGAAATTGTCCATC TAAAATAGAAACCACATGTTACATCTCGAGTCCTTTCTCTCGAGCCTTTCTTCAGTCGGGGCAGAGGCCCAGACTCATTGGAGACGGAGAGCCCTGGGCA GGGGGGGCAGCACCAGGGAGAAGCGCCGCGTGCCAGTGATCGGCTCCCATGGCTTCAGCATGGGCAGGAGTGGGGTAACGCACCCCATCCAGGTTGGGAA TCATCTGCAGGGCTAGCTATGAATGTGGGATACTCTGTCTTTGCTTTTCACCCGCTGAGTTCATCTTCTTTCCTAGAAGTAAACTGAAAAGGGCAGGGTT TTCTCATTGTCTGGTGGCCCTCTCACCAAAGCAGAAGTGAACATAGCCATGGGCAGGTTCAGCGGAGAGGTGGGTCCCAGAGCGCTGCGTGGCTGGCCTC CCACTCCTGCCCTGCACACCATCCTTGAGGGACTCCCTTGCGCCCATTTCCTCCTGGCCTCTACCTACTTTCTGCTGCTGCTTCCTCCCATACCCACAGA GTTCACGTTGAGCTGAGTGGGCCACTGTCCCCACTGTGGACACACTCTTTTATCGCAGCTACAGCACAGGAGGTGGGCTCTGCCCTCTTTCACAAATAAA TGACTTGTTCCAGGTCACAAGCCAGAAGTGGCATTCCCAGGCCAGGCAGCCCAGCTGGTGGCACCCGCAGTCTCCTACCCCCTCCCCTGCCATTTCCTAC TTCAGGACCAGGCGTCGCAGGAGTGGGGGAAAACAGGGATCTGTCCACACGGCTCTGGTTTAACACAGATGCAGCCCAGCAGCCTTTGGCGTCCTGCTGA TGGCCTGCACTGGCCCACGCCTGGCCCGTCCTCTGCAGGGCTCTCCAGCTGGCTGCCGGTGGCGGTGAGGGGCTGTCTTCGCGGCTCACCCACAATACTA CTGGCAAACTCTGCAAACCAAGTGGCAAGCAGTTCTGGCTGCCTTGTTGACTCCACGGCCCTGTCGTGTTTGGGGTAGCCATTGCCAGTCCCGTTTCCTC GCAACATCTCTCTTAATCACTTTCTCCCTGTGTTTTGCCGGGTTCCCTAGCCTTTACCTTTAGAGCTTTCTTTTTTTTTTTTTTTTGAGACGGAGTCTCG CTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTCACTGCAACTTCCACCTCCTGTGTTCAAGCAATTTTCCTGTCTCAGCCTCCCAAGTAGC TGGAGTTACAGGCGTGCGCTAGCACGCCCAGCTAATTTTTGTATTCTTAGTAGAGACAGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACC TCAGGTGATCCTCCGGCCTCAGCCTCCCAAAGTGCTGAGGTAAGCCACACCATACGCGTGAGCCACCATGCCCGGCCCTACCCTTAGTCTTGATATATCA GAAAAGCACTGTTTGATGTGCTTCAGTGTAAACCATTGTGGTTCGGTGAATTCTGGCAGGTCATCTGGAGGTTTCTTTGGAGAGCTTCTATCCTACTGGA AACCCAGGTTGGGCCCCATGTGGATTGATCGGCAGTGGGAATCAGCTAGGGCTGCTGTAACTGAGTTCGCAGACCCAGTGGCATAGACAGCAAAGAGGTA CTGCCACGTGGCTTTGGAGACCAGAAGTCTGAGAGGAAGGTGCTGGCAGGGCTGGTTCCTTCTGAGGCTGCAATGGAAAACCTGTCCTGGCCTCTCTCCT GGCATCTGCTGGTTATCTTTGGTGTTCCCTGTAGACAGCTGCCCCCTCCCTGTATCTTCATGTCGTCTTCCTTCTCTGTGTCCTTCTCTTCACGTAGTCT TTTTAGGACGCTGGTCGTGTTGCCTTAGGGCCCCCATGTCAGTGCCGTCATCTAGACTGATGATGCCCGCAGTGATCCTGTCTCCAGATAAGGTCATGTC CTGAGGTGTTCTGGGTTAGGACTTTGACGTTTGAATGGTGGGGGGTGGTGGACACAATTCAGCCCCTGACAGCAGCTTTTCTCTCCCCTCCCTGACGCTG TCGCAGCTGCAGTGACATGTACGAGAAAGTGCTGTGCACCAGCTGTGCCATGTTCGAGACCTGAGGCTGGCTCAAGCCGGCTGCCTTCACCGGGAGCCAC GCCGTGCATGGCAGCCTTCCCTGGACGAGCGCTCGGTGTTCACACTGAACTGTGGGGTCGACGGGAGGGGTGCCTTTTACATGTTCTATTTTGTATCCTA ATGACAGAATGAATAAACCTCTTTATATTTGCACAA

SIVA_HUMAN-3 (forward primer)
SIVA_HUMAN-4 (reverse primer)
Single exon skipping

Frame 0

CDVTASLVRGWRPGSCVAPGPAAMPKRSCPFAD VAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKR LLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTG APRAARGQMLIGPDGRLIRSLGQASEADPSGVA SIACSSCVRAVDGKAVCGQCERALCGQCVRTCWG CGSVACTLCGLVE*VLQSLELLRSHSPSKP*WG TGGSPMWAQNTHVWPLMQCHLALPNGTWWQ*ML GPTLVVSNPL*GKAEPHR*PALYPALVPVFSHFL F*SLSTPTSSSSGL*APPPPVRGAPGW*HRCTP QLHHSHACRLVVDPLRQEVECLCSLPFVGGFAA AGWIPSLLLRWGGAFSP*GLLTWWMGVDSVEPVC PAP*ER*LHPDTCGTGSIDPKQA*SKQCLKLSI *NRNHMLHLESFLSSLSSVGAEAQTHWRRRALG RGGSTREKRRVPVIGSHGFSMGRSGVTHPIQVGN HLQG*L*MWDTLSLLFTR*VHLLS*K*TEKGRV FSLSGGPLTKAEVNIAMGRFSGEVGPRALRGWP PTPALHTILEGLPCAHFLLASTYFLLLLPPIPTE FTLS*VGHCPHCGHTLLSQLQHRRWALPSFTNK *LVPGHKPEVAFPGQAAQLVAPAVSYPLPCHFL LQDQASQEWGKTGICPHGSGLTQMQPSSLWRPAD GLHWPTPGPSSAGLSSWLPVAVRGCLRGSPTIL LANSANQVASSSGCLVDSTALSCLG*PLPVPFP RNISLNHFLPVFCRVP*PLPLELSFFFFFETESR SVTQAGVQWCDLGSLQLPPPVFKQFSCLSLPSS WSYRRALARPANFCILSRDRVSPCWPGWSRTPD LR*SSGLSLPKC*GKPHHTREPPCPALPLVLIYQ KSTV*CASV*TIVVR*ILAGHLEVSLESFYPTG NPGWAPCGLIGSGNQLGLL*LSSQTQWHRQQRG TATWLWRPEV*EEGAGRAGSF*GCNGKPVLASLL ASAGYLWCSL*TAAPSLYLHVVFLLCVLLFT*S F*DAGRVALGPPCQCRHLD**CPQ*SCLQIRSC PEVFWVRTLTFEWWGVVDTIQPLTAAFLSPP*RC RSCSDMYEKVLCTSCAMFET*GWLKPAAFTGSH AVHGSLPWTSARCSH*TVGSTGGVPFTCSILYP NDRMNKPLYICT

Frame 1

VTSRRRW*GAGGRGAA*LPAPRPCPSGAAPSRT WPRYSSRSA*ARGS*AAACAPSATRRRSSRRPS DSCSSGPRPTWTTCGMKAVPSFTCQSPQSLALQG PRGLHVGRC*LDQTAA*SGALGRPPKLTHLG*R PLPVPHACEPWMGRRSAVSVSEPCAGSVCAPAG AAAPWPVPCVASWSKYFSPWSC*DPIAPASRDGG RVGHPCGPRTHTCGP*CSAIWHCLTGHGGNRCL AQL*WLVILSKGKLNLTDDLLCIRL*SLSSATS CSDL*APPPPPPLVFEPPLPPSEEPLVGDTGAHR SFTTVMRAVWL*TLSGRKWSVCVVSHLWVGLLQ LAGSRPYS*GGEGRSHPRGYSPGGWEWTVWSLF ALPREKDDFIQTHVELAP*TQSKLSPNNV*NCPS KIETTCYISSPFSRAFLQSGQRPRLIGDGEPWA GGAAPGRSAACQ*SAPMASAWAGVG*RTPSRLG IICRASYECGILCLCFSPAEFIFFPRSKLKRAGF SHCLVALSPKQK*T*PWAGSAERWVPERCVAGL PLLPCTPSLRDSLAPISSWPLPTFCCCFLPYPQ SSR*AEWATVPTVDTLFYRSYSTGGGLCPLSQIN DLFQVTSQKWHSQARQPSWWHPQSPTPSPAISY FRTRRRRSGGKQGSVHTALV*HRCSPAAFGVLL MACTGPRLARPLQGSPAGCRWR*GAVFAAHPQYY WQTLQTKWQAVLAALLTPRPCRVWGSHCQSRFL ATSLLITFSLCFAGFPSLYL*SFLFFFFLRRSL ALSPRLECSGAILAHCNFHLLCSSNFPVSASQVA GVTGVR*HAQLIFVFLVETEFHHVGQAGLELLT SGDPPASASQSAEVSHTIRVSHHARPYP*S*YI RKALFDVLQCKPLWFGEFWQVIWRFLWRASILLE TQVGPHVD*SAVGIS*GCCN*VRRPSGIDSKEV LPRGFGDQKSERKVLAGLVPSEAAMENLSWPLS WHLLVIFGVPCRQLPPPCIFMSSSFSVSFSSRSL FRTLVVLP*GPHVSAVI*TDDARSDPVSR*GHV LRCSGLGL*RLNGGGWWTQFSP*QQLFSPLPDA VAAAVTCTRKCCAPAVPCSRPEAGSSRLPSPGAT PCMAAFPGRALGVHTELWGRREGCLLHVLFCIL MTE*INLFIFAQ

Frame 2

*RHGVVGKGLAAGELRSSRPRGHAQAELPLRGR GPATAQGPREPEGVEPRRVRRALLAGGLREDQA TPVPRGPGLPGPRVG*RLCRRSPARVPKAWPYR GPEGCTWADADWTRRPPDQEPWAGLRS*PIWGSV HCLFLMRASRGWEGGLRSV*ASPVRAVCAHLLG LRLRGLYPVWPRGVSTSVPGAAEIP*PQQAVMG DGWVTHVGPEHTRVAPDAVPSGIA*RDMVAIDAW PNFSG**SSLRES*TSQMTCSVSGSSPCLQPLP VLIFEHPHLLLLWSLSPPSPRPRSPWLVTQVHT AASPQSCVPFGCRPSQAGSGVFV*SPICGWVCCS WLDPVLTPKVGRGVLTLGATHLVDGSGQCGACL PCPVRKMTSSRHMWNWLHRPKASLVQTMSEIVH LK*KPHVTSRVLSLEPFFSRGRGPDSLETESPGQ GGQHQGEAPRASDRLPWLQHGQEWGNAPHPGWE SSAGLAMNVGYSVFAFHPLSSSSFLEVN*KGQG FLIVWWPSHQSRSEHSHGQVQRRGGSQSAAWLAS HSCPAHHP*GTPLRPFPPGLYLLSAAASSHTHR VHVELSGPLSPLWTHSFIAATAQEVGSALFHK* MTCSRSQARSGIPRPGSPAGGTRSLLPPPLPFPT SGPGVAGVGENRDLSTRLWFNTDAAQQPLASC* WPALAHAWPVLCRALQLAAGGGEGLSSRLTHNT TGKLCKPSGKQFWLPC*LHGPVVFGVAIASPVSS QHLS*SLSPCVLPGSLAFTFRAFFFFFF*DGVS LCHPGWSAVVRSWLTATSTSCVQAIFLSQPPK* LELQACASTPS*FLYS**RQSFTMLARLVSNS*P QVILRPQPPKVLR*ATPYA*ATMPGPTLSLDIS EKHCLMCFSVNHCGSVNSGRSSGGFFGELLSYW KPRLGPMWIDRQWESARAAVTEFADPVA*TAKRY CHVALETRSLRGRCWQGWFLLRLQWKTCPGLSP GICWLSLVFPVDSCPLPVSSCRLPSLCPSLHVV FLGRWSCCLRAPMSVPSSRLMMPAVILSPDKVMS *GVLG*DFDV*MVGGGGHNSAPDSSFSLPSLTL SQLQ*HVRESAVHQLCHVRDLRLAQAGCLHREP RRAWQPSLDERSVFTLNCGVDGRGAFYMFYFVS* *QNE*TSLYLH

Sequence SIVA.cAug05

TGTGACGTCACGGCGTCGTTGGTAAGGGGCTGGCGGCCGGGGAGCTGCGTAGCTCCCGGCCCCGCGGCCATGCCCAAGCGGAGCTGCCCCTTCGCGGACG TGGCCCCGCTACAGCTCAAGGTCCGCGTGAGCCAGAGGGAGTTGAGCCGCGGCGTGTGCGCCGAGCGCTACTCGCAGGAGGTCTTCGAGAAGACCAAGCG ACTCCTGTTCCTCGGGGCCCAGGCCTACCTGGACCACGTGTGGGATGAAGGCTGTGCCGTCGTTCACCTGCCAGAGTCCCCAAAGCCTGGCCCTACAGGG GCCCCGAGGGCTGCACGTGGGCAGATGCTGATTGGACCAGACGGCCGCCTGATCAGGAGCCTTGGGCAGGCCTCCGAAGCTGACCCATCTGGGGTAGCGT CCATTGCCTGTTCCTCATGCGTGCGAGCCGTGGATGGGAAGGCGGTCTGCGGTCAGTGTGAGCGAGCCCTGTGCGGGCAGTGTGTGCGCACCTGCTGGGG CTGCGGCTCCGTGGCCTGTACCCTGTGTGGCCTCGTGGAGGGCTACTCACCTGGTGGATGGGAGTGGACAGTGTGGAGCCTGTTTGCCCTGCCCCGTGAG AAAGATGACTTCATCCAGACACATGTGGAACTGGCTCCATAGACCCAAAGCAAGCTTAGTCCAAACAATGTCTGAAATTGTCCATCTAAAATAGAAACCA CATGTTACATCTCGAGTCCTTTCTCTCGAGCCTTTCTTCAGTCGGGGCAGAGGCCCAGACTCATTGGAGACGGAGAGCCCTGGGCAGGGGGGGCAGCACC AGGGAGAAGCGCCGCGTGCCAGTGATCGGCTCCCATGGCTTCAGCATGGGCAGGAGTGGGGTAACGCACCCCATCCAGGTTGGGAATCATCTGCAGGGCT AGCTATGAATGTGGGATACTCTGTCTTTGCTTTTCACCCGCTGAGTTCATCTTCTTTCCTAGAAGTAAACTGAAAAGGGCAGGGTTTTCTCATTGTCTGG TGGCCCTCTCACCAAAGCAGAAGTGAACATAGCCATGGGCAGGTTCAGCGGAGAGGTGGGTCCCAGAGCGCTGCGTGGCTGGCCTCCCACTCCTGCCCTG CACACCATCCTTGAGGGACTCCCTTGCGCCCATTTCCTCCTGGCCTCTACCTACTTTCTGCTGCTGCTTCCTCCCATACCCACAGAGTTCACGTTGAGCT GAGTGGGCCACTGTCCCCACTGTGGACACACTCTTTTATCGCAGCTACAGCACAGGAGGTGGGCTCTGCCCTCTTTCACAAATAAATGACTTGTTCCAGG TCACAAGCCAGAAGTGGCATTCCCAGGCCAGGCAGCCCAGCTGGTGGCACCCGCAGTCTCCTACCCCCTCCCCTGCCATTTCCTACTTCAGGACCAGGCG TCGCAGGAGTGGGGGAAAACAGGGATCTGTCCACACGGCTCTGGTTTAACACAGATGCAGCCCAGCAGCCTTTGGCGTCCTGCTGATGGCCTGCACTGGC CCACGCCTGGCCCGTCCTCTGCAGGGCTCTCCAGCTGGCTGCCGGTGGCGGTGAGGGGCTGTCTTCGCGGCTCACCCACAATACTACTGGCAAACTCTGC AAACCAAGTGGCAAGCAGTTCTGGCTGCCTTGTTGACTCCACGGCCCTGTCGTGTTTGGGGTAGCCATTGCCAGTCCCGTTTCCTCGCAACATCTCTCTT AATCACTTTCTCCCTGTGTTTTGCCGGGTTCCCTAGCCTTTACCTTTAGAGCTTTCTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGG CTGGAGTGCAGTGGTGCGATCTTGGCTCACTGCAACTTCCACCTCCTGTGTTCAAGCAATTTTCCTGTCTCAGCCTCCCAAGTAGCTGGAGTTACAGGCG TGCGCTAGCACGCCCAGCTAATTTTTGTATTCTTAGTAGAGACAGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCTCC GGCCTCAGCCTCCCAAAGTGCTGAGGTAAGCCACACCATACGCGTGAGCCACCATGCCCGGCCCTACCCTTAGTCTTGATATATCAGAAAAGCACTGTTT GATGTGCTTCAGTGTAAACCATTGTGGTTCGGTGAATTCTGGCAGGTCATCTGGAGGTTTCTTTGGAGAGCTTCTATCCTACTGGAAACCCAGGTTGGGC CCCATGTGGATTGATCGGCAGTGGGAATCAGCTAGGGCTGCTGTAACTGAGTTCGCAGACCCAGTGGCATAGACAGCAAAGAGGTACTGCCACGTGGCTT TGGAGACCAGAAGTCTGAGAGGAAGGTGCTGGCAGGGCTGGTTCCTTCTGAGGCTGCAATGGAAAACCTGTCCTGGCCTCTCTCCTGGCATCTGCTGGTT ATCTTTGGTGTTCCCTGTAGACAGCTGCCCCCTCCCTGTATCTTCATGTCGTCTTCCTTCTCTGTGTCCTTCTCTTCACGTAGTCTTTTTAGGACGCTGG TCGTGTTGCCTTAGGGCCCCCATGTCAGTGCCGTCATCTAGACTGATGATGCCCGCAGTGATCCTGTCTCCAGATAAGGTCATGTCCTGAGGTGTTCTGG GTTAGGACTTTGACGTTTGAATGGTGGGGGGTGGTGGACACAATTCAGCCCCTGACAGCAGCTTTTCTCTCCCCTCCCTGACGCTGTCGCAGCTGCAGTG ACATGTACGAGAAAGTGCTGTGCACCAGCTGTGCCATGTTCGAGACCTGAGGCTGGCTCAAGCCGGCTGCCTTCACCGGGAGCCACGCCGTGCATGGCAG CCTTCCCTGGACGAGCGCTCGGTGTTCACACTGAACTGTGGGGTCGACGGGAGGGGTGCCTTTTACATGTTCTATTTTGTATCCTAATGACAGAATGAAT AAACCTCTTTATATTTGCACAA

SIVA_HUMAN-3 (forward primer)
SIVA_HUMAN-4 (reverse primer)
Single exon skipping

Frame 0

CDVTASLVRGWRPGSCVAPGPAAMPKRSCPFAD VAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKR LLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTG APRAARGQMLIGPDGRLIRSLGQASEADPSGVA SIACSSCVRAVDGKAVCGQCERALCGQCVRTCWG CGSVACTLCGLVEGYSPGGWEWTVWSLFALPRE KDDFIQTHVELAP*TQSKLSPNNV*NCPSKIET TCYISSPFSRAFLQSGQRPRLIGDGEPWAGGAAP GRSAACQ*SAPMASAWAGVG*RTPSRLGIICRA SYECGILCLCFSPAEFIFFPRSKLKRAGFSHCL VALSPKQK*T*PWAGSAERWVPERCVAGLPLLPC TPSLRDSLAPISSWPLPTFCCCFLPYPQSSR*A EWATVPTVDTLFYRSYSTGGGLCPLSQINDLFQ VTSQKWHSQARQPSWWHPQSPTPSPAISYFRTRR RRSGGKQGSVHTALV*HRCSPAAFGVLLMACTG PRLARPLQGSPAGCRWR*GAVFAAHPQYYWQTL QTKWQAVLAALLTPRPCRVWGSHCQSRFLATSLL ITFSLCFAGFPSLYL*SFLFFFFLRRSLALSPR LECSGAILAHCNFHLLCSSNFPVSASQVAGVTG VR*HAQLIFVFLVETEFHHVGQAGLELLTSGDPP ASASQSAEVSHTIRVSHHARPYP*S*YIRKALF DVLQCKPLWFGEFWQVIWRFLWRASILLETQVG PHVD*SAVGIS*GCCN*VRRPSGIDSKEVLPRGF GDQKSERKVLAGLVPSEAAMENLSWPLSWHLLV IFGVPCRQLPPPCIFMSSSFSVSFSSRSLFRTL VVLP*GPHVSAVI*TDDARSDPVSR*GHVLRCSG LGL*RLNGGGWWTQFSP*QQLFSPLPDAVAAAV TCTRKCCAPAVPCSRPEAGSSRLPSPGATPCMA AFPGRALGVHTELWGRREGCLLHVLFCILMTE*I NLFIFAQ

Frame 1

VTSRRRW*GAGGRGAA*LPAPRPCPSGAAPSRT WPRYSSRSA*ARGS*AAACAPSATRRRSSRRPS DSCSSGPRPTWTTCGMKAVPSFTCQSPQSLALQG PRGLHVGRC*LDQTAA*SGALGRPPKLTHLG*R PLPVPHACEPWMGRRSAVSVSEPCAGSVCAPAG AAAPWPVPCVASWRATHLVDGSGQCGACLPCPVR KMTSSRHMWNWLHRPKASLVQTMSEIVHLK*KP HVTSRVLSLEPFFSRGRGPDSLETESPGQGGQH QGEAPRASDRLPWLQHGQEWGNAPHPGWESSAGL AMNVGYSVFAFHPLSSSSFLEVN*KGQGFLIVW WPSHQSRSEHSHGQVQRRGGSQSAAWLASHSCP AHHP*GTPLRPFPPGLYLLSAAASSHTHRVHVEL SGPLSPLWTHSFIAATAQEVGSALFHK*MTCSR SQARSGIPRPGSPAGGTRSLLPPPLPFPTSGPG VAGVGENRDLSTRLWFNTDAAQQPLASC*WPALA HAWPVLCRALQLAAGGGEGLSSRLTHNTTGKLC KPSGKQFWLPC*LHGPVVFGVAIASPVSSQHLS *SLSPCVLPGSLAFTFRAFFFFFF*DGVSLCHPG WSAVVRSWLTATSTSCVQAIFLSQPPK*LELQA CASTPS*FLYS**RQSFTMLARLVSNS*PQVIL RPQPPKVLR*ATPYA*ATMPGPTLSLDISEKHCL MCFSVNHCGSVNSGRSSGGFFGELLSYWKPRLG PMWIDRQWESARAAVTEFADPVA*TAKRYCHVA LETRSLRGRCWQGWFLLRLQWKTCPGLSPGICWL SLVFPVDSCPLPVSSCRLPSLCPSLHVVFLGRW SCCLRAPMSVPSSRLMMPAVILSPDKVMS*GVL G*DFDV*MVGGGGHNSAPDSSFSLPSLTLSQLQ* HVRESAVHQLCHVRDLRLAQAGCLHREPRRAWQ PSLDERSVFTLNCGVDGRGAFYMFYFVS**QNE *TSLYLH

Frame 2

*RHGVVGKGLAAGELRSSRPRGHAQAELPLRGR GPATAQGPREPEGVEPRRVRRALLAGGLREDQA TPVPRGPGLPGPRVG*RLCRRSPARVPKAWPYR GPEGCTWADADWTRRPPDQEPWAGLRS*PIWGSV HCLFLMRASRGWEGGLRSV*ASPVRAVCAHLLG LRLRGLYPVWPRGGLLTWWMGVDSVEPVCPAP* ER*LHPDTCGTGSIDPKQA*SKQCLKLSI*NRNH MLHLESFLSSLSSVGAEAQTHWRRRALGRGGST REKRRVPVIGSHGFSMGRSGVTHPIQVGNHLQG *L*MWDTLSLLFTR*VHLLS*K*TEKGRVFSLSG GPLTKAEVNIAMGRFSGEVGPRALRGWPPTPAL HTILEGLPCAHFLLASTYFLLLLPPIPTEFTLS *VGHCPHCGHTLLSQLQHRRWALPSFTNK*LVPG HKPEVAFPGQAAQLVAPAVSYPLPCHFLLQDQA SQEWGKTGICPHGSGLTQMQPSSLWRPADGLHW PTPGPSSAGLSSWLPVAVRGCLRGSPTILLANSA NQVASSSGCLVDSTALSCLG*PLPVPFPRNISL NHFLPVFCRVP*PLPLELSFFFFFETESRSVTQ AGVQWCDLGSLQLPPPVFKQFSCLSLPSSWSYRR ALARPANFCILSRDRVSPCWPGWSRTPDLR*SS GLSLPKC*GKPHHTREPPCPALPLVLIYQKSTV *CASV*TIVVR*ILAGHLEVSLESFYPTGNPGWA PCGLIGSGNQLGLL*LSSQTQWHRQQRGTATWL WRPEV*EEGAGRAGSF*GCNGKPVLASLLASAG YLWCSL*TAAPSLYLHVVFLLCVLLFT*SF*DAG RVALGPPCQCRHLD**CPQ*SCLQIRSCPEVFW VRTLTFEWWGVVDTIQPLTAAFLSPP*RCRSCS DMYEKVLCTSCAMFET*GWLKPAAFTGSHAVHGS LPWTSARCSH*TVGSTGGVPFTCSILYPNDRMN KPLYICT

Sequence SIVA.eAug05

SIVA_HUMAN-3 (forward primer)
SIVA_HUMAN-4 (reverse primer)
Single exon skipping

Frame 0

CDVTASLVRGWRPGSCVAPGPAAMPKRSCPFAD VAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKR LLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTG APRAARGQMLIGPDGRLIRSLGQASEADPSGVA SIACSSCVRAVDGKAVCGQCERALCGQCVRTCWG CGSVACTLCGLVDDMYEKVLCTSCAMFET*GWL KPAAFTGSHAVHGSLPWTSARCSH*TVGSTGGV PFTCSILYPNDRMNKPLYICTRG

Frame 1

VTSRRRW*GAGGRGAA*LPAPRPCPSGAAPSRT WPRYSSRSA*ARGS*AAACAPSATRRRSSRRPS DSCSSGPRPTWTTCGMKAVPSFTCQSPQSLALQG PRGLHVGRC*LDQTAA*SGALGRPPKLTHLG*R PLPVPHACEPWMGRRSAVSVSEPCAGSVCAPAG AAAPWPVPCVASWMTCTRKCCAPAVPCSRPEAGS SRLPSPGATPCMAAFPGRALGVHTELWGRREGC LLHVLFCILMTE*INLFIFAQED

Frame 2

*RHGVVGKGLAAGELRSSRPRGHAQAELPLRGR GPATAQGPREPEGVEPRRVRRALLAGGLREDQA TPVPRGPGLPGPRVG*RLCRRSPARVPKAWPYR GPEGCTWADADWTRRPPDQEPWAGLRS*PIWGSV HCLFLMRASRGWEGGLRSV*ASPVRAVCAHLLG LRLRGLYPVWPRG*HVRESAVHQLCHVRDLRLA QAGCLHREPRRAWQPSLDERSVFTLNCGVDGRGA FYMFYFVS**QNE*TSLYLHKR

Sequence SIVA.aAug05

SIVA_HUMAN-3 (forward primer)
SIVA_HUMAN-4 (reverse primer)
Single exon skipping

Frame 0

CDVTASLVRGWRPGSCVAPGPAAMPKRSCPFAD VAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKR LLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTG APRAARGQMLIGPDGRLIRSLGQASEADPSGVA SIACSSCVRAVDGKAVCGQCERALCGQCVRTCWG CGSVACTLCGLVDCSDMYEKVLCTSCAMFET*G WLKPAAFTGSHAVHGSLPWTSARCSH*TVGSTG GVPFTCSILYPNDRMNKPLYICTRG

Frame 1

VTSRRRW*GAGGRGAA*LPAPRPCPSGAAPSRT WPRYSSRSA*ARGS*AAACAPSATRRRSSRRPS DSCSSGPRPTWTTCGMKAVPSFTCQSPQSLALQG PRGLHVGRC*LDQTAA*SGALGRPPKLTHLG*R PLPVPHACEPWMGRRSAVSVSEPCAGSVCAPAG AAAPWPVPCVASWTAVTCTRKCCAPAVPCSRPEA GSSRLPSPGATPCMAAFPGRALGVHTELWGRRE GCLLHVLFCILMTE*INLFIFAQED

Frame 2

*RHGVVGKGLAAGELRSSRPRGHAQAELPLRGR GPATAQGPREPEGVEPRRVRRALLAGGLREDQA TPVPRGPGLPGPRVG*RLCRRSPARVPKAWPYR GPEGCTWADADWTRRPPDQEPWAGLRS*PIWGSV HCLFLMRASRGWEGGLRSV*ASPVRAVCAHLLG LRLRGLYPVWPRGLQ*HVRESAVHQLCHVRDLR LAQAGCLHREPRRAWQPSLDERSVFTLNCGVDGR GAFYMFYFVS**QNE*TSLYLHKR