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Sequences

Sequence BCL2L11.nAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTAT
TGGAGACGAGTTTAACGCTTACTATGCAAGGAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAA
GCGTTTGAGACGGAGCTGTGGAGGCTGAATCCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACG
AATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCT
TGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACAC
CGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAA
TATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGA
AATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAAC
TGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATT
GCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATA
TACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGT
GATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTAT
CTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGC
AATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCAT
CAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCT
GATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCAC
CAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGT
GAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCA
AGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACT
TTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGT
GGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAAT
ACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTC
GAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTG
GATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACA
CACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCT
CCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGA
CTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATT
TTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTG
ACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTG
GGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAG
TATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATA
AGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCT
GTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCAT
GAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCA
GTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTC
CAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAA
ACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGG
TGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTT
GTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACA
GCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTT
GGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGAT
TTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCAT
TGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGAT
TCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGG
ACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATAC
TGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Alternative donor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQASMRQAEPADMRPEIWIAQELRRI
GDEFNAYYARRLEK*RKLSCSCHVFSPLKGSGE
AFETELWRLNP*RRR*ERHRYF*IITKQPKTTH
EWLSYDCYVTLSAWCGECIDRFFAEPRYHADILL
VQTNKTQHRGLLVPLLCSQRFSCGGGR*RFRRH
RAGWDYLSVHHHTAEFLMEVCCECKGGSILCFL
IYKPWFFGAGFCVRMVFTCSVFSPSPSIRFFKKE
METF*PICE*LLY*NFKNLRPILRGLCNPCSGN
*AS*LKKLP*FIFRDYRIFKQGDV*YTPSLPYY
CLSDLFKLFLIPKEFF*NGTD*KGRGSVASLH*Y
TSPICKYLRTFINSVASVAKFQTIFASFLITFC
DATPVWTQMHRFGPVYFHDKVKLSQNKS*YLPV
SCTVRAICY*LGSIWCWFSFHFDEHVIGKYSEEA
IAVITTDLSATPLCAAGFSGCRLSHGHRMHCQH
QVPEGHRVHYSRVQLQHPAHALMGIGTGLGQGF
*WPFAWPPAF*SNSQSTSFTPLNSL*NRPHPTST
STIEE*FWAEVCFFSFFQDSWILSGHL*PQPCS
EGALSLCLLLMSAVEGSHTLVSHFRGSRCPGRP
KKESG*GAVKVRREDNSVNSVTLKIFENSIVKQL
LKEITKFSNE*AVPPTSVLPDRRASMFTLFKLG
GKI*TFLSS*FKKYICIYCIFTFSFR*R*FQSK
YSYFKKFPFPKNLLGTLTYF*SCVGAHLVP*CVS
SPLVGSYKAHGYKQW*DCSRGPAGHTHTPKMYL
DLGTPSQDPCTHVPVS*LEHFTLFPQPCSPWEH
TLGAALGQAREALPCAAQGLCAPHEHISLWPGGL
QAGCGNSS*GN*RFYEL*EY*RPGCWHQNLKR*
LDVSVLYVSGYQDASVQKVCLPWVYVFTFFKKH
FCRKNN*IPFLETYCRFCALTTSPYVRFVKSVL*
LNTETQ*THTK*FHE*FFRCPSQLVS*SRILGV
GVAEKSSLKFLLIKKI*WNTIVCRFPFLMYIL*
VFIRFVGHITYQLSQMSVCNCVSFTL*NFVQHK*
VKKSLFFSTFSKSRIVNIVDSFSV*CVLLFHNA
VTCRNIVYLFSAYLMS*FLKSINIPVSHSPAVP
*S*LLRVVGGDWRAHCRPRGPPGWLSTFGSWYFQ
SSGFQFLGFAALMMKCVFDASEKLSLAGYKILL
QEIPSNLLFVPKQLAYHASKFC*LQALSLGKQK
NQSIISRWERFFY*KFIPDNSAFRKEIKCATSRG
AALQLFRARARQDK*MGGTGGSCLRTTSGH*PL
VDNCE*LGFPPPAVQLPVL*GWTNLSSGAN*LY
SPPHAPPIRSLHLVSLLLQVDALLLILHLLQGRL
GPHWTGCQDVKAYGSFKETSWWFHAGGSAIPAD
LAWCLCVSTHVHVGWGKRVYR*R*ISWGLL*TA
LCVRSILKLPVK*LDYFYLGISDYRSSLMFYVQI
L*PLVTVSELIRYPLINSTDLAVY*SITNLFSR
TQRM*HLYCSFPGLLVFCTDEF*QGNCHFTCAI
LL*ITADF*TIFYVNFIKIKLSTSF

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKLP*GRLNLQICAQRYGSPKSCGV
LETSLTLTMQGG*RNRGSCRVVVMYSVHLRAVGK
RLRRSCGG*ILEGGGERGTGIFE*LPSSRRPPT
NGYLTTVTLHCPPGVENALTGSLRSRDTMQTFC
LFKPTRPSTAVSWCHYYAASGSLVEGAGDVSEDT
ELDGTTFLFITTQQNF*WKFVVNVKEGAFFAF*
YTNHGFLEQDFV*EWCLHAVCFPPHLQ*GFSKR
KWKLFNQFVNNFCIKILRTYGLFSEDYVTPAVET
EPANLKSCLSLFLEITEFLNRETCDILPPFPTI
ASLTFLNYF*YQKSSFEMELIKRAEGLLPACID
IPVPFVNIYVPL*IQLHLWQNFRLFLRLSSSLFV
MQLQSGLRCIDLVQCIFMIK*N*VRTRVNICLY
LAQFERSVINWEAFGVGFHSISTSMLLGSILKR
Q*Q**QQT*VLRPFVLLAFLVAGFPMVTGCTVSI
RSQRATVSITAESSCSIQLTPSWELAQAWGRAS
DGHLLGLLHFSPTHSPLASLL*IHFETGLIPLP
PAP*KNNSGQKSVFFHFSRTVGYCQATCDPSHVV
RVLFLCACSL*VQWKEATHWSVISEAADAQGDP
RKSQVREQ*K*GGKTIL*TL*LLKFLKTPSLNN
F*KK*LNFQMSKQCHQLVFCPIEEPACSRYLN*V
EKSKHFYLHNLKNIYVYIAYSLFPLGRDDFNPN
TLTLKNFLSPRISLGL*LIFKAVLELILFPDVS
RAHW*GHTKPTVTSSGRIAAVGLLDTHIHQRCIW
IWAPPPRIPVLTCQSPD*STLLCFLSPAAPGST
HWVQPWARHGRPCPVLPRGCVHHMSTFPSGLAA
SRLAVETVPEEIRDSMNCRSIKDQAVGTRT*SDD
WMSLYCMYLVIKMPLCRKYASRGYTFLPFLKNI
FVEKIIKSPFWKLTAGFVP*QPLPM*GL*KVSC
DLTQKRNKHTQNSFMSDSSDALPNWLVDQEFWGW
GLRRNQV*NSF*LKKYSGIQLSAVSPS*CIYCE
YLLDS*VILLIN*AKCLCAIVFPLPCKILYSIN
K*KNHCFSQLFQNQGL*IL*ILFLCDVSYCFIML
*LVEILYIYFLLI*CLNF*KVLTSLSPTPLPSH
EVNS*ELSGVTGELIADHVVLQGGSPPSGPGIS
SQVGFNSWALPPL**SVCLMPVRNSVWQATKFYS
KKYPATFCLFQSN*LIMQANFADSRLYL*ENKK
TKVLSAGGKDFSIENLSLTTQRLEKK*NVPLPE
VLHCSCSGLGPGRTSEWVGQVAPA*GPPQATNPL
WTTVSSWVFPHLLCNFLCFEVGLTCLQELINCT
ALPTPHPYGHCIWSACFFRSMPSF*YSISFRGG
WGPTGLGVKM*KLMGALRRLHGGSMQVVLPSLLI
*PGACVCPLTYTWGGGNVSTDDAKSVGVYSKQH
CV*EASSSSQLSNLTTFIWEFQTIEALLCFMSR
FCDH*LLYQNSSGTHL*IALIWLYTDPSLTCFLG
PSVCSICIAVSLAYLCFALMNFDRVIATLLVQY
CCK*LQIFKQSFMLIL*K*NFQLV

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATSFHEAG*TCRYAPRDMDRPRVAAY
WRRV*RLLCKEVREIEEVVV*LSCIQST*GQWG
SV*DGAVEAESLKEEVREAQVFLNNYQAAEDHPR
MVILRLLRYIVRLVWRMH*QVLCGAEIPCRHFA
CSNQQDPAPRSPGAIIMQPAVLLWRGQVTFQKT
PSWMGLPFCSSPHSRISNGSLL*M*RREHSLLFN
IQTMVFWSRILCKNGVYMQCVFPLTFNKVFQKG
NGNFLTNL*ITFVLKF*EPTAYSQRIM*PLQWK
LSQLT*KAALVYF*RLQNF*TGRRVIYSLPSLLL
PL*PF*IIFNTKRVLLKWN*LKGQRVCCQPALI
YQSHL*IFTYLYKFSCICGKISDYFCVFPHHFL
*CNSSLDSDA*IWSSVFS**SEIESEQELISACI
LHSSSDLLLTGKHLVLVFIPFRRACYWEVF*RG
NSSNNNRLKCYAPLCCWLFWLQAFPWSQDALSA
SGPRGPPCPLQQSPAAASSSRPHGNWHRPGAGLL
MAICLASCILVQLTVH*LHSFKFTLKQASSHFH
QHHRRIILGRSLFFFIFPGQLDIVRPLVTPAM*
*GCSFSVPAPYECSGRKPHTGQSFQRQQMPRETQ
ERVRLGSSESEEGRQFCELCNS*NF*KLHR*TT
FKRNN*IFK*VSSATN*CFAR*KSQHVHVI*IR
WKNLNIFIFII*KIYMYILHIHFFL*VEMISIQI
LLL*KISFPQESPWDFDLFLKLCWSSSCSLMCL
EPIGRVIQSPRLQAVVGLQPWACWTHTYTKDVF
GSGHPLPGSLYSRASLLTRALYSVSSALQPLGAH
TGCSPGPGTGGPALCCPGAVCTT*AHFPLAWRP
PGWLWKQFLRKLEIL*IVGVLKTRLLAPELKAM
TGCLCTVCIWLSRCLCAESMPPVGIRFYLF*KTF
L*KK*LNPLFGNLLQVLCLDNLSLCEVCKKCPV
T*HRNAINTHKIVS*VILQMPFPTG*LIKNFGG
GGCGEIKFKIPSD*KNIVEYNCLPFPLLNVYIVS
IY*IRRSYYLSTEPNVCVQLCFLYLVKFCTA*I
SKKITVFLNFFKIKDCKYCRFFFCVMCPTVS*C
CNL*KYCIFIFCLFNVLISEKY*HPCLPLPCRPM
KLTPESCRG*LESSLQTTWSSRVALHLRVLVFP
VKWVSILGLCRPYDEVCV*CQ*ETQSGRLQNST
PRNTQQPSVCSKATSLSCKQILLTPGFIFRKTKK
PKYYQQVGKIFLLKIYP*QLSV*KRNKMCHFQR
CCIAVVQG*GQAGQVNGWDRWLLPKDHLRPLTP
CGQL*VAGFSPTCCATSCALRLD*LVFRS*LTVQ
PSPRPTHTVTAFGQPASSGRCPPSDTPSPSGEV
GAPLDWVSRCESLWEL*GDFMVVPCRWFCHPC*
FSLVPVCVHSRTRGVGETCLQMTLNQLGSTLNSI
VCKKHPQAPS*VT*LLLFGNFRL*KLSYVLCPD
SVTTSYCIRTHQVPTYK*H*SGCILIHH*PVF*
DPAYVAFVLQFPWLTCVLH**ILTG*LPLYLCNT
AVNNCRFLNNLLC*FYKNKTFN*F

Sequence BCL2L11.mAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTAT
TGGAGACGAGTTTAACGCTTACTATGCAAGGAGGCTGGCAAAACTCCTGGCATCCTCCACCTGACATAAACCAGTTCACAGAACATTCCAGCCTAGATCT
GAAATGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGACGGAGCTGTGGAGGCTGA
ATCCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTAC
ATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGC
GGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTC
ATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGG
ATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAA
TAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTT
AGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTT
AATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGT
ACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGC
ATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTA
ACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGT
GCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATT
ACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATT
TTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCA
GAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCC
TTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAA
AGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAAT
GAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCAT
AATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCC
CAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCC
CACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCT
GTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACG
GGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGA
GGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTG
GTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTT
TTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACAC
ACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAAT
TCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTAC
TTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACT
TTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTAT
TTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGG
TGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTT
GCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTG
TTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAG
ATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGG
GCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTC
CCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTC
ACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGAT
GTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTC
ACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCC
AGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAA
CTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCA
GTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAAC
AATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Alternative donor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQASMRQAEPADMRPEIWIAQELRRI
GDEFNAYYARRLAKLLASST*HKPVHRTFQPRS
EMLEK*RKLSCSCHVFSPLKGSGEAFETELWRL
NP*RRR*ERHRYF*IITKQPKTTHEWLSYDCYVT
LSAWCGECIDRFFAEPRYHADILLVQTNKTQHR
GLLVPLLCSQRFSCGGGR*RFRRHRAGWDYLSV
HHHTAEFLMEVCCECKGGSILCFLIYKPWFFGAG
FCVRMVFTCSVFSPSPSIRFFKKEMETF*PICE
*LLY*NFKNLRPILRGLCNPCSGN*AS*LKKLP
*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKLFL
IPKEFF*NGTD*KGRGSVASLH*YTSPICKYLR
TFINSVASVAKFQTIFASFLITFCDATPVWTQM
HRFGPVYFHDKVKLSQNKS*YLPVSCTVRAICY*
LGSIWCWFSFHFDEHVIGKYSEEAIAVITTDLS
ATPLCAAGFSGCRLSHGHRMHCQHQVPEGHRVH
YSRVQLQHPAHALMGIGTGLGQGF*WPFAWPPAF
*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*FWA
EVCFFSFFQDSWILSGHL*PQPCSEGALSLCLL
LMSAVEGSHTLVSHFRGSRCPGRPKKESG*GAVK
VRREDNSVNSVTLKIFENSIVKQLLKEITKFSN
E*AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS
*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFPFP
KNLLGTLTYF*SCVGAHLVP*CVSSPLVGSYKA
HGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQDP
CTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQAR
EALPCAAQGLCAPHEHISLWPGGLQAGCGNSS*
GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLYVS
GYQDASVQKVCLPWVYVFTFFKKHFCRKNN*IPF
LETYCRFCALTTSPYVRFVKSVL*LNTETQ*TH
TK*FHE*FFRCPSQLVS*SRILGVGVAEKSSLK
FLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGHIT
YQLSQMSVCNCVSFTL*NFVQHK*VKKSLFFST
FSKSRIVNIVDSFSV*CVLLFHNAVTCRNIVYL
FSAYLMS*FLKSINIPVSHSPAVP*S*LLRVVGG
DWRAHCRPRGPPGWLSTFGSWYFQSSGFQFLGF
AALMMKCVFDASEKLSLAGYKILLQEIPSNLLF
VPKQLAYHASKFC*LQALSLGKQKNQSIISRWER
FFY*KFIPDNSAFRKEIKCATSRGAALQLFRAR
ARQDK*MGGTGGSCLRTTSGH*PLVDNCE*LGF
PPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPIRS
LHLVSLLLQVDALLLILHLLQGRLGPHWTGCQD
VKAYGSFKETSWWFHAGGSAIPADLAWCLCVST
HVHVGWGKRVYR*R*ISWGLL*TALCVRSILKLP
VK*LDYFYLGISDYRSSLMFYVQIL*PLVTVSE
LIRYPLINSTDLAVY*SITNLFSRTQRM*HLYC
SFPGLLVFCTDEF*QGNCHFTCAILL*ITADF*T
IFYVNFIKIKLSTSF

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKLP*GRLNLQICAQRYGSPKSCGV
LETSLTLTMQGGWQNSWHPPPDINQFTEHSSLDL
KC*RNRGSCRVVVMYSVHLRAVGKRLRRSCGG*
ILEGGGERGTGIFE*LPSSRRPPTNGYLTTVTL
HCPPGVENALTGSLRSRDTMQTFCLFKPTRPSTA
VSWCHYYAASGSLVEGAGDVSEDTELDGTTFLF
ITTQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQ
DFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVN
NFCIKILRTYGLFSEDYVTPAVETEPANLKSCL
SLFLEITEFLNRETCDILPPFPTIASLTFLNYF
*YQKSSFEMELIKRAEGLLPACIDIPVPFVNIYV
PL*IQLHLWQNFRLFLRLSSSLFVMQLQSGLRC
IDLVQCIFMIK*N*VRTRVNICLYLAQFERSVI
NWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT*V
LRPFVLLAFLVAGFPMVTGCTVSIRSQRATVSI
TAESSCSIQLTPSWELAQAWGRASDGHLLGLLH
FSPTHSPLASLL*IHFETGLIPLPPAP*KNNSGQ
KSVFFHFSRTVGYCQATCDPSHVVRVLFLCACS
L*VQWKEATHWSVISEAADAQGDPRKSQVREQ*
K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNFQM
SKQCHQLVFCPIEEPACSRYLN*VEKSKHFYLH
NLKNIYVYIAYSLFPLGRDDFNPNTLTLKNFLS
PRISLGL*LIFKAVLELILFPDVSRAHW*GHTKP
TVTSSGRIAAVGLLDTHIHQRCIWIWAPPPRIP
VLTCQSPD*STLLCFLSPAAPGSTHWVQPWARH
GRPCPVLPRGCVHHMSTFPSGLAASRLAVETVPE
EIRDSMNCRSIKDQAVGTRT*SDDWMSLYCMYL
VIKMPLCRKYASRGYTFLPFLKNIFVEKIIKSP
FWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNKHT
QNSFMSDSSDALPNWLVDQEFWGWGLRRNQV*N
SF*LKKYSGIQLSAVSPS*CIYCEYLLDS*VIL
LIN*AKCLCAIVFPLPCKILYSINK*KNHCFSQL
FQNQGL*IL*ILFLCDVSYCFIML*LVEILYIY
FLLI*CLNF*KVLTSLSPTPLPSHEVNS*ELSG
VTGELIADHVVLQGGSPPSGPGISSQVGFNSWAL
PPL**SVCLMPVRNSVWQATKFYSKKYPATFCL
FQSN*LIMQANFADSRLYL*ENKKTKVLSAGGK
DFSIENLSLTTQRLEKK*NVPLPEVLHCSCSGLG
PGRTSEWVGQVAPA*GPPQATNPLWTTVSSWVF
PHLLCNFLCFEVGLTCLQELINCTALPTPHPYG
HCIWSACFFRSMPSF*YSISFRGGWGPTGLGVKM
*KLMGALRRLHGGSMQVVLPSLLI*PGACVCPL
TYTWGGGNVSTDDAKSVGVYSKQHCV*EASSSS
QLSNLTTFIWEFQTIEALLCFMSRFCDH*LLYQN
SSGTHL*IALIWLYTDPSLTCFLGPSVCSICIA
VSLAYLCFALMNFDRVIATLLVQYCCK*LQIFK
QSFMLIL*K*NFQLV

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATSFHEAG*TCRYAPRDMDRPRVAAY
WRRV*RLLCKEAGKTPGILHLT*TSSQNIPA*I
*NVREIEEVVV*LSCIQST*GQWGSV*DGAVEAE
SLKEEVREAQVFLNNYQAAEDHPRMVILRLLRY
IVRLVWRMH*QVLCGAEIPCRHFACSNQQDPAP
RSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPFCS
SPHSRISNGSLL*M*RREHSLLFNIQTMVFWSR
ILCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*
ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KAAL
VYF*RLQNF*TGRRVIYSLPSLLLPL*PF*IIF
NTKRVLLKWN*LKGQRVCCQPALIYQSHL*IFT
YLYKFSCICGKISDYFCVFPHHFL*CNSSLDSDA
*IWSSVFS**SEIESEQELISACILHSSSDLLL
TGKHLVLVFIPFRRACYWEVF*RGNSSNNNRLK
CYAPLCCWLFWLQAFPWSQDALSASGPRGPPCPL
QQSPAAASSSRPHGNWHRPGAGLLMAICLASCI
LVQLTVH*LHSFKFTLKQASSHFHQHHRRIILG
RSLFFFIFPGQLDIVRPLVTPAM**GCSFSVPAP
YECSGRKPHTGQSFQRQQMPRETQERVRLGSSE
SEEGRQFCELCNS*NF*KLHR*TTFKRNN*IFK
*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFIFI
I*KIYMYILHIHFFL*VEMISIQILLL*KISFP
QESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQS
PRLQAVVGLQPWACWTHTYTKDVFGSGHPLPGSL
YSRASLLTRALYSVSSALQPLGAHTGCSPGPGT
GGPALCCPGAVCTT*AHFPLAWRPPGWLWKQFL
RKLEIL*IVGVLKTRLLAPELKAMTGCLCTVCIW
LSRCLCAESMPPVGIRFYLF*KTFL*KK*LNPL
FGNLLQVLCLDNLSLCEVCKKCPVT*HRNAINT
HKIVS*VILQMPFPTG*LIKNFGGGGCGEIKFKI
PSD*KNIVEYNCLPFPLLNVYIVSIY*IRRSYY
LSTEPNVCVQLCFLYLVKFCTA*ISKKITVFLN
FFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCIFI
FCLFNVLISEKY*HPCLPLPCRPMKLTPESCRG
*LESSLQTTWSSRVALHLRVLVFPVKWVSILGL
CRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVC
SKATSLSCKQILLTPGFIFRKTKKPKYYQQVGK
IFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*
GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAGFS
PTCCATSCALRLD*LVFRS*LTVQPSPRPTHTV
TAFGQPASSGRCPPSDTPSPSGEVGAPLDWVSR
CESLWEL*GDFMVVPCRWFCHPC*FSLVPVCVHS
RTRGVGETCLQMTLNQLGSTLNSIVCKKHPQAP
S*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIR
THQVPTYK*H*SGCILIHH*PVF*DPAYVAFVLQ
FPWLTCVLH**ILTG*LPLYLCNTAVNNCRFLN
NLLC*FYKNKTFN*F

Sequence BCL2L11.kAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTAT
TGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGT
TACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCAC
CGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTG
TTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGC
AGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGT
GAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGC
CTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATT
TTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTA
CGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGA
TGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTA
TTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTA
AGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCC
ATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGC
ATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGG
GCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGC
TCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGT
GAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCA
AATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTT
CATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTT
CCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAA
GCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATC
CCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGC
ACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCC
TGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTAT
CTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCC
CTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACA
CACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAA
AATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATAT
TACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCA
ACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATT
TATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGG
GGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGC
TTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGT
TTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGA
AAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCT
AGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTT
TTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACG
GTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAA
GATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCA
CTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCT
CCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCA
GAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATT
GCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTA
AACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Alternative donor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQASMRQAEPADMRPEIWIAQELRRI
GDEFNAYYARRVFLNNYQAAEDHPRMVILRLLR
YIVRLVWRMH*QVLCGAEIPCRHFACSNQQDPA
PRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPFC
SSPHSRISNGSLL*M*RREHSLLFNIQTMVFWS
RILCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL
*ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KAA
LVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*II
FNTKRVLLKWN*LKGQRVCCQPALIYQSHL*IF
TYLYKFSCICGKISDYFCVFPHHFL*CNSSLDSD
A*IWSSVFS**SEIESEQELISACILHSSSDLL
LTGKHLVLVFIPFRRACYWEVF*RGNSSNNNRL
KCYAPLCCWLFWLQAFPWSQDALSASGPRGPPCP
LQQSPAAASSSRPHGNWHRPGAGLLMAICLASC
ILVQLTVH*LHSFKFTLKQASSHFHQHHRRIIL
GRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVPA
PYECSGRKPHTGQSFQRQQMPRETQERVRLGSS
ESEEGRQFCELCNS*NF*KLHR*TTFKRNN*IF
K*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFIF
II*KIYMYILHIHFFL*VEMISIQILLL*KISF
PQESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQ
SPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPGS
LYSRASLLTRALYSVSSALQPLGAHTGCSPGPG
TGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQF
LRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVCI
WLSRCLCAESMPPVGIRFYLF*KTFL*KK*LNP
LFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAIN
THKIVS*VILQMPFPTG*LIKNFGGGGCGEIKFK
IPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRSY
YLSTEPNVCVQLCFLYLVKFCTA*ISKKITVFL
NFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCIF
IFCLFNVLISEKY*HPCLPLPCRPMKLTPESCR
G*LESSLQTTWSSRVALHLRVLVFPVKWVSILG
LCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPSV
CSKATSLSCKQILLTPGFIFRKTKKPKYYQQVG
KIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG
*GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAGF
SPTCCATSCALRLD*LVFRS*LTVQPSPRPTHT
VTAFGQPASSGRCPPSDTPSPSGEVGAPLDWVS
RCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCVH
SRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQA
PS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCI
RTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFVL
QFPWLTCVLH**ILTG*LPLYLCNTAVNNCRFL
NNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKLP*GRLNLQICAQRYGSPKSCGV
LETSLTLTMQGGYF*IITKQPKTTHEWLSYDCYV
TLSAWCGECIDRFFAEPRYHADILLVQTNKTQH
RGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYLS
VHHHTAEFLMEVCCECKGGSILCFLIYKPWFFGA
GFCVRMVFTCSVFSPSPSIRFFKKEMETF*PIC
E*LLY*NFKNLRPILRGLCNPCSGN*AS*LKKL
P*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKLF
LIPKEFF*NGTD*KGRGSVASLH*YTSPICKYL
RTFINSVASVAKFQTIFASFLITFCDATPVWTQ
MHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAICY
*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTDL
SATPLCAAGFSGCRLSHGHRMHCQHQVPEGHRV
HYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPPA
F*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*FW
AEVCFFSFFQDSWILSGHL*PQPCSEGALSLCL
LLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GAV
KVRREDNSVNSVTLKIFENSIVKQLLKEITKFS
NE*AVPPTSVLPDRRASMFTLFKLGGKI*TFLS
S*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFPF
PKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSYK
AHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQD
PCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQA
REALPCAAQGLCAPHEHISLWPGGLQAGCGNSS
*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLYV
SGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*IP
FLETYCRFCALTTSPYVRFVKSVL*LNTETQ*T
HTK*FHE*FFRCPSQLVS*SRILGVGVAEKSSL
KFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGHI
TYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFFS
TFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIVY
LFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVVG
GDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFLG
FAALMMKCVFDASEKLSLAGYKILLQEIPSNLL
FVPKQLAYHASKFC*LQALSLGKQKNQSIISRWE
RFFY*KFIPDNSAFRKEIKCATSRGAALQLFRA
RARQDK*MGGTGGSCLRTTSGH*PLVDNCE*LG
FPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPIR
SLHLVSLLLQVDALLLILHLLQGRLGPHWTGCQ
DVKAYGSFKETSWWFHAGGSAIPADLAWCLCVS
THVHVGWGKRVYR*R*ISWGLL*TALCVRSILKL
PVK*LDYFYLGISDYRSSLMFYVQIL*PLVTVS
ELIRYPLINSTDLAVY*SITNLFSRTQRM*HLY
CSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF*
TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATSFHEAG*TCRYAPRDMDRPRVAAY
WRRV*RLLCKEGIFE*LPSSRRPPTNGYLTTVT
LHCPPGVENALTGSLRSRDTMQTFCLFKPTRPST
AVSWCHYYAASGSLVEGAGDVSEDTELDGTTFL
FITTQQNF*WKFVVNVKEGAFFAF*YTNHGFLE
QDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFV
NNFCIKILRTYGLFSEDYVTPAVETEPANLKSC
LSLFLEITEFLNRETCDILPPFPTIASLTFLNY
F*YQKSSFEMELIKRAEGLLPACIDIPVPFVNIY
VPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGLR
CIDLVQCIFMIK*N*VRTRVNICLYLAQFERSV
INWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT*
VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATVS
ITAESSCSIQLTPSWELAQAWGRASDGHLLGLL
HFSPTHSPLASLL*IHFETGLIPLPPAP*KNNSG
QKSVFFHFSRTVGYCQATCDPSHVVRVLFLCAC
SL*VQWKEATHWSVISEAADAQGDPRKSQVREQ
*K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNFQ
MSKQCHQLVFCPIEEPACSRYLN*VEKSKHFYL
HNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNFL
SPRISLGL*LIFKAVLELILFPDVSRAHW*GHTK
PTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPRI
PVLTCQSPD*STLLCFLSPAAPGSTHWVQPWAR
HGRPCPVLPRGCVHHMSTFPSGLAASRLAVETVP
EEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCMY
LVIKMPLCRKYASRGYTFLPFLKNIFVEKIIKS
PFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNKH
TQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV*
NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*VI
LLIN*AKCLCAIVFPLPCKILYSINK*KNHCFSQ
LFQNQGL*IL*ILFLCDVSYCFIML*LVEILYI
YFLLI*CLNF*KVLTSLSPTPLPSHEVNS*ELS
GVTGELIADHVVLQGGSPPSGPGISSQVGFNSWA
LPPL**SVCLMPVRNSVWQATKFYSKKYPATFC
LFQSN*LIMQANFADSRLYL*ENKKTKVLSAGG
KDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSGL
GPGRTSEWVGQVAPA*GPPQATNPLWTTVSSWV
FPHLLCNFLCFEVGLTCLQELINCTALPTPHPY
GHCIWSACFFRSMPSF*YSISFRGGWGPTGLGVK
M*KLMGALRRLHGGSMQVVLPSLLI*PGACVCP
LTYTWGGGNVSTDDAKSVGVYSKQHCV*EASSS
SQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLYQ
NSSGTHL*IALIWLYTDPSLTCFLGPSVCSICI
AVSLAYLCFALMNFDRVIATLLVQYCCK*LQIF
KQSFMLIL*K*NFQLV

Sequence BCL2L11.cAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAG
GAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGACGGAGCTGTGGAGGCTGAAT
CCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACAT
TGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGG
TCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCAT
CACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGAT
TTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATA
ACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAG
TTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAA
TACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTAC
CTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCAT
AGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAAC
TGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGC
TACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTAC
AGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTT
AGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGA
AGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTT
ATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAG
TGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGA
GTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAA
TTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCA
AGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCA
CGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGT
ACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGG
AGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGG
AAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGT
TATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTT
TGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACAC
AAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTC
CTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTT
ATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTT
TTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTT
TCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTG
ACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGC
CGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTT
CCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGAT
TTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGC
CAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCC
CCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCAC
TGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGT
GAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCAC
GTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAG
TTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACT
CATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGT
TTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAA
TCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Alternative donor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYAR
RLEK*RKLSCSCHVFSPLKGSGEAFETELWRLN
P*RRR*ERHRYF*IITKQPKTTHEWLSYDCYVT
LSAWCGECIDRFFAEPRYHADILLVQTNKTQHRG
LLVPLLCSQRFSCGGGR*RFRRHRAGWDYLSVH
HHTAEFLMEVCCECKGGSILCFLIYKPWFFGAG
FCVRMVFTCSVFSPSPSIRFFKKEMETF*PICE*
LLY*NFKNLRPILRGLCNPCSGN*AS*LKKLP*
FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKLFL
IPKEFF*NGTD*KGRGSVASLH*YTSPICKYLRT
FINSVASVAKFQTIFASFLITFCDATPVWTQMH
RFGPVYFHDKVKLSQNKS*YLPVSCTVRAICY*
LGSIWCWFSFHFDEHVIGKYSEEAIAVITTDLSA
TPLCAAGFSGCRLSHGHRMHCQHQVPEGHRVHY
SRVQLQHPAHALMGIGTGLGQGF*WPFAWPPAF
*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*FWAE
VCFFSFFQDSWILSGHL*PQPCSEGALSLCLLL
MSAVEGSHTLVSHFRGSRCPGRPKKESG*GAVK
VRREDNSVNSVTLKIFENSIVKQLLKEITKFSNE
*AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS*
FKKYICIYCIFTFSFR*R*FQSKYSYFKKFPFP
KNLLGTLTYF*SCVGAHLVP*CVSSPLVGSYKAH
GYKQW*DCSRGPAGHTHTPKMYLDLGTPSQDPC
THVPVS*LEHFTLFPQPCSPWEHTLGAALGQAR
EALPCAAQGLCAPHEHISLWPGGLQAGCGNSS*G
N*RFYEL*EY*RPGCWHQNLKR*LDVSVLYVSG
YQDASVQKVCLPWVYVFTFFKKHFCRKNN*IPF
LETYCRFCALTTSPYVRFVKSVL*LNTETQ*THT
K*FHE*FFRCPSQLVS*SRILGVGVAEKSSLKF
LLIKKI*WNTIVCRFPFLMYIL*VFIRFVGHIT
YQLSQMSVCNCVSFTL*NFVQHK*VKKSLFFSTF
SKSRIVNIVDSFSV*CVLLFHNAVTCRNIVYLF
SAYLMS*FLKSINIPVSHSPAVP*S*LLRVVGG
DWRAHCRPRGPPGWLSTFGSWYFQSSGFQFLGFA
ALMMKCVFDASEKLSLAGYKILLQEIPSNLLFV
PKQLAYHASKFC*LQALSLGKQKNQSIISRWER
FFY*KFIPDNSAFRKEIKCATSRGAALQLFRARA
RQDK*MGGTGGSCLRTTSGH*PLVDNCE*LGFP
PPAVQLPVL*GWTNLSSGAN*LYSPPHAPPIRS
LHLVSLLLQVDALLLILHLLQGRLGPHWTGCQDV
KAYGSFKETSWWFHAGGSAIPADLAWCLCVSTH
VHVGWGKRVYR*R*ISWGLL*TALCVRSILKLP
VK*LDYFYLGISDYRSSLMFYVQIL*PLVTVSEL
IRYPLINSTDLAVY*SITNLFSRTQRM*HLYCS
FPGLLVFCTDEF*QGNCHFTCAILL*ITADF*T
IFYVNFIKIKLSTSF

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LP*GRLNLQICAQRYGSPKSCGVLETSLTLTMQ
GG*RNRGSCRVVVMYSVHLRAVGKRLRRSCGG*I
LEGGGERGTGIFE*LPSSRRPPTNGYLTTVTLH
CPPGVENALTGSLRSRDTMQTFCLFKPTRPSTA
VSWCHYYAASGSLVEGAGDVSEDTELDGTTFLFI
TTQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQD
FV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVN
NFCIKILRTYGLFSEDYVTPAVETEPANLKSCLS
LFLEITEFLNRETCDILPPFPTIASLTFLNYF*
YQKSSFEMELIKRAEGLLPACIDIPVPFVNIYV
PL*IQLHLWQNFRLFLRLSSSLFVMQLQSGLRCI
DLVQCIFMIK*N*VRTRVNICLYLAQFERSVIN
WEAFGVGFHSISTSMLLGSILKRQ*Q**QQT*V
LRPFVLLAFLVAGFPMVTGCTVSIRSQRATVSIT
AESSCSIQLTPSWELAQAWGRASDGHLLGLLHF
SPTHSPLASLL*IHFETGLIPLPPAP*KNNSGQ
KSVFFHFSRTVGYCQATCDPSHVVRVLFLCACSL
*VQWKEATHWSVISEAADAQGDPRKSQVREQ*K
*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNFQM
SKQCHQLVFCPIEEPACSRYLN*VEKSKHFYLHN
LKNIYVYIAYSLFPLGRDDFNPNTLTLKNFLSP
RISLGL*LIFKAVLELILFPDVSRAHW*GHTKP
TVTSSGRIAAVGLLDTHIHQRCIWIWAPPPRIPV
LTCQSPD*STLLCFLSPAAPGSTHWVQPWARHG
RPCPVLPRGCVHHMSTFPSGLAASRLAVETVPE
EIRDSMNCRSIKDQAVGTRT*SDDWMSLYCMYLV
IKMPLCRKYASRGYTFLPFLKNIFVEKIIKSPF
WKLTAGFVP*QPLPM*GL*KVSCDLTQKRNKHT
QNSFMSDSSDALPNWLVDQEFWGWGLRRNQV*NS
F*LKKYSGIQLSAVSPS*CIYCEYLLDS*VILL
IN*AKCLCAIVFPLPCKILYSINK*KNHCFSQL
FQNQGL*IL*ILFLCDVSYCFIML*LVEILYIYF
LLI*CLNF*KVLTSLSPTPLPSHEVNS*ELSGV
TGELIADHVVLQGGSPPSGPGISSQVGFNSWAL
PPL**SVCLMPVRNSVWQATKFYSKKYPATFCLF
QSN*LIMQANFADSRLYL*ENKKTKVLSAGGKD
FSIENLSLTTQRLEKK*NVPLPEVLHCSCSGLG
PGRTSEWVGQVAPA*GPPQATNPLWTTVSSWVFP
HLLCNFLCFEVGLTCLQELINCTALPTPHPYGH
CIWSACFFRSMPSF*YSISFRGGWGPTGLGVKM
*KLMGALRRLHGGSMQVVLPSLLI*PGACVCPLT
YTWGGGNVSTDDAKSVGVYSKQHCV*EASSSSQ
LSNLTTFIWEFQTIEALLCFMSRFCDH*LLYQN
SSGTHL*IALIWLYTDPSLTCFLGPSVCSICIAV
SLAYLCFALMNFDRVIATLLVQYCCK*LQIFKQ
SFMLIL*K*NFQLV

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
FHEAG*TCRYAPRDMDRPRVAAYWRRV*RLLCK
EVREIEEVVV*LSCIQST*GQWGSV*DGAVEAE
SLKEEVREAQVFLNNYQAAEDHPRMVILRLLRYI
VRLVWRMH*QVLCGAEIPCRHFACSNQQDPAPR
SPGAIIMQPAVLLWRGQVTFQKTPSWMGLPFCS
SPHSRISNGSLL*M*RREHSLLFNIQTMVFWSRI
LCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*I
TFVLKF*EPTAYSQRIM*PLQWKLSQLT*KAAL
VYF*RLQNF*TGRRVIYSLPSLLLPL*PF*IIFN
TKRVLLKWN*LKGQRVCCQPALIYQSHL*IFTY
LYKFSCICGKISDYFCVFPHHFL*CNSSLDSDA
*IWSSVFS**SEIESEQELISACILHSSSDLLLT
GKHLVLVFIPFRRACYWEVF*RGNSSNNNRLKC
YAPLCCWLFWLQAFPWSQDALSASGPRGPPCPL
QQSPAAASSSRPHGNWHRPGAGLLMAICLASCIL
VQLTVH*LHSFKFTLKQASSHFHQHHRRIILGR
SLFFFIFPGQLDIVRPLVTPAM**GCSFSVPAP
YECSGRKPHTGQSFQRQQMPRETQERVRLGSSES
EEGRQFCELCNS*NF*KLHR*TTFKRNN*IFK*
VSSATN*CFAR*KSQHVHVI*IRWKNLNIFIFI
I*KIYMYILHIHFFL*VEMISIQILLL*KISFPQ
ESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQSP
RLQAVVGLQPWACWTHTYTKDVFGSGHPLPGSL
YSRASLLTRALYSVSSALQPLGAHTGCSPGPGTG
GPALCCPGAVCTT*AHFPLAWRPPGWLWKQFLR
KLEIL*IVGVLKTRLLAPELKAMTGCLCTVCIW
LSRCLCAESMPPVGIRFYLF*KTFL*KK*LNPLF
GNLLQVLCLDNLSLCEVCKKCPVT*HRNAINTH
KIVS*VILQMPFPTG*LIKNFGGGGCGEIKFKI
PSD*KNIVEYNCLPFPLLNVYIVSIY*IRRSYYL
STEPNVCVQLCFLYLVKFCTA*ISKKITVFLNF
FKIKDCKYCRFFFCVMCPTVS*CCNL*KYCIFI
FCLFNVLISEKY*HPCLPLPCRPMKLTPESCRG*
LESSLQTTWSSRVALHLRVLVFPVKWVSILGLC
RPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVC
SKATSLSCKQILLTPGFIFRKTKKPKYYQQVGKI
FLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*G
QAGQVNGWDRWLLPKDHLRPLTPCGQL*VAGFS
PTCCATSCALRLD*LVFRS*LTVQPSPRPTHTVT
AFGQPASSGRCPPSDTPSPSGEVGAPLDWVSRC
ESLWEL*GDFMVVPCRWFCHPC*FSLVPVCVHS
RTRGVGETCLQMTLNQLGSTLNSIVCKKHPQAPS
*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIRT
HQVPTYK*H*SGCILIHH*PVF*DPAYVAFVLQ
FPWLTCVLH**ILTG*LPLYLCNTAVNNCRFLNN
LLC*FYKNKTFN*F

Sequence BCL2L11.bAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAG
GAGGATGCCTCTTCCACCTGATTAAGAACCACTGTAGCAGACGCAGACTTATTGGACACTAGGCGGGAGGCCAGCTCTGCAGACAGCAGGTCTCAGGAAG
ACGGTCAAGGCATGGCTGCTGATGATCCGCTTATGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTAC
GTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGC
ACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTC
TGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGA
GCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTT
GTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCT
GCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTA
TTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATT
TACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCA
GATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGT
TATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACT
TAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGT
CCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCT
GCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCT
GGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCT
GCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCA
GTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTT
CAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATC
TTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCT
TTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACA
AAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGA
TCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAG
GCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTT
CCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGT
ATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATC
CCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAA
CACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTT
AAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCAT
ATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCT
CAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATA
TTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTC
GGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGG
GCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCT
GTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGG
GAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGG
CTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGG
TTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATA
CGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTC
AAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTC
CACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAG
CTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTAT
CAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTA
TTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTT
TAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Alternative donor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYAR
RMPLPPD*EPL*QTQTYWTLGGRPALQTAGLRK
TVKAWLLMIRLWVFLNNYQAAEDHPRMVILRLL
RYIVRLVWRMH*QVLCGAEIPCRHFACSNQQDPA
PRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPF
CSSPHSRISNGSLL*M*RREHSLLFNIQTMVFW
SRILCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL
*ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KA
ALVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*I
IFNTKRVLLKWN*LKGQRVCCQPALIYQSHL*IF
TYLYKFSCICGKISDYFCVFPHHFL*CNSSLDS
DA*IWSSVFS**SEIESEQELISACILHSSSDL
LLTGKHLVLVFIPFRRACYWEVF*RGNSSNNNRL
KCYAPLCCWLFWLQAFPWSQDALSASGPRGPPC
PLQQSPAAASSSRPHGNWHRPGAGLLMAICLAS
CILVQLTVH*LHSFKFTLKQASSHFHQHHRRIIL
GRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVP
APYECSGRKPHTGQSFQRQQMPRETQERVRLGS
SESEEGRQFCELCNS*NF*KLHR*TTFKRNN*IF
K*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFI
FII*KIYMYILHIHFFL*VEMISIQILLL*KIS
FPQESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQ
SPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPG
SLYSRASLLTRALYSVSSALQPLGAHTGCSPGP
GTGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQF
LRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVC
IWLSRCLCAESMPPVGIRFYLF*KTFL*KK*LN
PLFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAIN
THKIVS*VILQMPFPTG*LIKNFGGGGCGEIKF
KIPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRS
YYLSTEPNVCVQLCFLYLVKFCTA*ISKKITVFL
NFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCI
FIFCLFNVLISEKY*HPCLPLPCRPMKLTPESC
RG*LESSLQTTWSSRVALHLRVLVFPVKWVSILG
LCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPS
VCSKATSLSCKQILLTPGFIFRKTKKPKYYQQV
GKIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG
*GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAG
FSPTCCATSCALRLD*LVFRS*LTVQPSPRPTH
TVTAFGQPASSGRCPPSDTPSPSGEVGAPLDWVS
RCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCV
HSRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQ
APS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCI
RTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFV
LQFPWLTCVLH**ILTG*LPLYLCNTAVNNCRF
LNNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LP*GRLNLQICAQRYGSPKSCGVLETSLTLTMQ
GGCLFHLIKNHCSRRRLIGH*AGGQLCRQQVSGR
RSRHGC**SAYGYF*IITKQPKTTHEWLSYDCY
VTLSAWCGECIDRFFAEPRYHADILLVQTNKTQ
HRGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYLS
VHHHTAEFLMEVCCECKGGSILCFLIYKPWFFG
AGFCVRMVFTCSVFSPSPSIRFFKKEMETF*PI
CE*LLY*NFKNLRPILRGLCNPCSGN*AS*LKKL
P*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKL
FLIPKEFF*NGTD*KGRGSVASLH*YTSPICKY
LRTFINSVASVAKFQTIFASFLITFCDATPVWTQ
MHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAIC
Y*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTD
LSATPLCAAGFSGCRLSHGHRMHCQHQVPEGHRV
HYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPP
AF*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*F
WAEVCFFSFFQDSWILSGHL*PQPCSEGALSLCL
LLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GA
VKVRREDNSVNSVTLKIFENSIVKQLLKEITKF
SNE*AVPPTSVLPDRRASMFTLFKLGGKI*TFLS
S*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFP
FPKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSY
KAHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQD
PCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQ
AREALPCAAQGLCAPHEHISLWPGGLQAGCGNS
S*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLYV
SGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*I
PFLETYCRFCALTTSPYVRFVKSVL*LNTETQ*
THTK*FHE*FFRCPSQLVS*SRILGVGVAEKSSL
KFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGH
ITYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFF
STFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIVY
LFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVV
GGDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFL
GFAALMMKCVFDASEKLSLAGYKILLQEIPSNLL
FVPKQLAYHASKFC*LQALSLGKQKNQSIISRW
ERFFY*KFIPDNSAFRKEIKCATSRGAALQLFR
ARARQDK*MGGTGGSCLRTTSGH*PLVDNCE*LG
FPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPI
RSLHLVSLLLQVDALLLILHLLQGRLGPHWTGC
QDVKAYGSFKETSWWFHAGGSAIPADLAWCLCVS
THVHVGWGKRVYR*R*ISWGLL*TALCVRSILK
LPVK*LDYFYLGISDYRSSLMFYVQIL*PLVTV
SELIRYPLINSTDLAVY*SITNLFSRTQRM*HLY
CSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF
*TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
FHEAG*TCRYAPRDMDRPRVAAYWRRV*RLLCK
EDASST*LRTTVADADLLDTRREASSADSRSQE
DGQGMAADDPLMGIFE*LPSSRRPPTNGYLTTVT
LHCPPGVENALTGSLRSRDTMQTFCLFKPTRPS
TAVSWCHYYAASGSLVEGAGDVSEDTELDGTTF
LFITTQQNF*WKFVVNVKEGAFFAF*YTNHGFLE
QDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQF
VNNFCIKILRTYGLFSEDYVTPAVETEPANLKS
CLSLFLEITEFLNRETCDILPPFPTIASLTFLNY
F*YQKSSFEMELIKRAEGLLPACIDIPVPFVNI
YVPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGL
RCIDLVQCIFMIK*N*VRTRVNICLYLAQFERSV
INWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT
*VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATV
SITAESSCSIQLTPSWELAQAWGRASDGHLLGLL
HFSPTHSPLASLL*IHFETGLIPLPPAP*KNNS
GQKSVFFHFSRTVGYCQATCDPSHVVRVLFLCA
CSL*VQWKEATHWSVISEAADAQGDPRKSQVREQ
*K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNF
QMSKQCHQLVFCPIEEPACSRYLN*VEKSKHFY
LHNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNFL
SPRISLGL*LIFKAVLELILFPDVSRAHW*GHT
KPTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPR
IPVLTCQSPD*STLLCFLSPAAPGSTHWVQPWAR
HGRPCPVLPRGCVHHMSTFPSGLAASRLAVETV
PEEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCM
YLVIKMPLCRKYASRGYTFLPFLKNIFVEKIIKS
PFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNK
HTQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV
*NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*VI
LLIN*AKCLCAIVFPLPCKILYSINK*KNHCFS
QLFQNQGL*IL*ILFLCDVSYCFIML*LVEILY
IYFLLI*CLNF*KVLTSLSPTPLPSHEVNS*ELS
GVTGELIADHVVLQGGSPPSGPGISSQVGFNSW
ALPPL**SVCLMPVRNSVWQATKFYSKKYPATF
CLFQSN*LIMQANFADSRLYL*ENKKTKVLSAGG
KDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSG
LGPGRTSEWVGQVAPA*GPPQATNPLWTTVSSW
VFPHLLCNFLCFEVGLTCLQELINCTALPTPHPY
GHCIWSACFFRSMPSF*YSISFRGGWGPTGLGV
KM*KLMGALRRLHGGSMQVVLPSLLI*PGACVC
PLTYTWGGGNVSTDDAKSVGVYSKQHCV*EASSS
SQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLY
QNSSGTHL*IALIWLYTDPSLTCFLGPSVCSIC
IAVSLAYLCFALMNFDRVIATLLVQYCCK*LQIF
KQSFMLIL*K*NFQLV

Sequence BCL2L11.aAug05

GCCGCCTGGTCTGCAGTTTGTTGGAGCTCTGCGTCCAGCGCCGCTGCCGCTGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACTACCA
CCACTTGATTCTTGCAGCCACCCTGCGAACCCTGCCACACTGCGATCGCATCATCGCGGTATTCGGTTCGCTGCGTTCCCGCCGCCACCGCCTCGGCGCC
CTTTCTTGGCCCTTGTTCCCCCAAATGTCTGACTCTGACTCTCGGACTGAGAAACGCAAGAAAAAAAGACCAAATGGCAAAGCAACCTTCTGATGTAAGT
TCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGGTA
ATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGCCCCACCTGCCAGCCCTGGCCCTTTTGCTACCAG
ATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCTTTTGACACAGACAGGAGCCCAGCACCCATGAGT
TGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGC
GCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGA
AGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGC
AGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGT
TTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTC
TTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTT
TTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCC
TGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCC
TTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAG
CCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTC
ATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAAT
ATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTA
TTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATG
CACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGG
GGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCA
TCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCC
CAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCC
CAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCAT
CGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTA
TTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGAT
TTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCC
CTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCA
AAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCC
CCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTG
GCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAAC
TTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTT
TTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAA
AAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGA
ATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGT
ATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGT
ACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTG
TTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCC
CTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTC
CTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTAC
AAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAG
GAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGC
CACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGC
CACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTA
ATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCT
TCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCC
ATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTAC
TCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTT
TTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAAC
CTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTA
CTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Alternative donor

Frame 0

AAWSAVCWSSASSAAAAAAAAAAAAAAAAAATT
TT*FLQPPCEPCHTAIASSRYSVRCVPAATASAP
FLGPCSPKCLTLTLGLRNARKKDQMAKQPSDVS
SECDREGRQLQPAERPPQLRPGAPTSLQTEPQG
NPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATR
SPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMS
CDKSTQTPSPPCQAFNHYLSAMASMRQAEPADM
RPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAE
DHPRMVILRLLRYIVRLVWRMH*QVLCGAEIPC
RHFACSNQQDPAPRSPGAIIMQPAVLLWRGQVT
FQKTPSWMGLPFCSSPHSRISNGSLL*M*RREHS
LLFNIQTMVFWSRILCKNGVYMQCVFPLTFNKV
FQKGNGNFLTNL*ITFVLKF*EPTAYSQRIM*P
LQWKLSQLT*KAALVYF*RLQNF*TGRRVIYSLP
SLLLPL*PF*IIFNTKRVLLKWN*LKGQRVCCQ
PALIYQSHL*IFTYLYKFSCICGKISDYFCVFP
HHFL*CNSSLDSDA*IWSSVFS**SEIESEQELI
SACILHSSSDLLLTGKHLVLVFIPFRRACYWEV
F*RGNSSNNNRLKCYAPLCCWLFWLQAFPWSQD
ALSASGPRGPPCPLQQSPAAASSSRPHGNWHRPG
AGLLMAICLASCILVQLTVH*LHSFKFTLKQAS
SHFHQHHRRIILGRSLFFFIFPGQLDIVRPLVT
PAM**GCSFSVPAPYECSGRKPHTGQSFQRQQMP
RETQERVRLGSSESEEGRQFCELCNS*NF*KLH
R*TTFKRNN*IFK*VSSATN*CFAR*KSQHVHV
I*IRWKNLNIFIFII*KIYMYILHIHFFL*VEMI
SIQILLL*KISFPQESPWDFDLFLKLCWSSSCS
LMCLEPIGRVIQSPRLQAVVGLQPWACWTHTYT
KDVFGSGHPLPGSLYSRASLLTRALYSVSSALQP
LGAHTGCSPGPGTGGPALCCPGAVCTT*AHFPL
AWRPPGWLWKQFLRKLEIL*IVGVLKTRLLAPE
LKAMTGCLCTVCIWLSRCLCAESMPPVGIRFYLF
*KTFL*KK*LNPLFGNLLQVLCLDNLSLCEVCK
KCPVT*HRNAINTHKIVS*VILQMPFPTG*LIK
NFGGGGCGEIKFKIPSD*KNIVEYNCLPFPLLNV
YIVSIY*IRRSYYLSTEPNVCVQLCFLYLVKFC
TA*ISKKITVFLNFFKIKDCKYCRFFFCVMCPT
VS*CCNL*KYCIFIFCLFNVLISEKY*HPCLPLP
CRPMKLTPESCRG*LESSLQTTWSSRVALHLRV
LVFPVKWVSILGLCRPYDEVCV*CQ*ETQSGRL
QNSTPRNTQQPSVCSKATSLSCKQILLTPGFIFR
KTKKPKYYQQVGKIFLLKIYP*QLSV*KRNKMC
HFQRCCIAVVQG*GQAGQVNGWDRWLLPKDHLR
PLTPCGQL*VAGFSPTCCATSCALRLD*LVFRS*
LTVQPSPRPTHTVTAFGQPASSGRCPPSDTPSP
SGEVGAPLDWVSRCESLWEL*GDFMVVPCRWFC
HPC*FSLVPVCVHSRTRGVGETCLQMTLNQLGST
LNSIVCKKHPQAPS*VT*LLLFGNFRL*KLSYV
LCPDSVTTSYCIRTHQVPTYK*H*SGCILIHH*
PVF*DPAYVAFVLQFPWLTCVLH**ILTG*LPLY
LCNTAVNNCRFLNNLLC*FYKNKTFN*F

Frame 1

PPGLQFVGALRPAPLPLPPPPPPPPPPPPPPLP
PLDSCSHPANPATLRSHHRGIRFAAFPPPPPRR
PFLALVPPNV*L*LSD*ETQEKKTKWQSNLLM*V
LSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKV
ILKAITEVKGTAAPTAALRARWPHLPALALLLP
DPRFSSL*EDPPCCLDPPVGISLLTQTGAQHP*V
VTNQHKPQVLLARPSTTISVQWLP*GRLNLQIC
AQRYGSPKSCGVLETSLTLTMQGGYF*IITKQP
KTTHEWLSYDCYVTLSAWCGECIDRFFAEPRYHA
DILLVQTNKTQHRGLLVPLLCSQRFSCGGGR*R
FRRHRAGWDYLSVHHHTAEFLMEVCCECKGGSI
LCFLIYKPWFFGAGFCVRMVFTCSVFSPSPSIRF
FKKEMETF*PICE*LLY*NFKNLRPILRGLCNP
CSGN*AS*LKKLP*FIFRDYRIFKQGDV*YTPS
LPYYCLSDLFKLFLIPKEFF*NGTD*KGRGSVAS
LH*YTSPICKYLRTFINSVASVAKFQTIFASFL
ITFCDATPVWTQMHRFGPVYFHDKVKLSQNKS*
YLPVSCTVRAICY*LGSIWCWFSFHFDEHVIGKY
SEEAIAVITTDLSATPLCAAGFSGCRLSHGHRM
HCQHQVPEGHRVHYSRVQLQHPAHALMGIGTGL
GQGF*WPFAWPPAF*SNSQSTSFTPLNSL*NRPH
PTSTSTIEE*FWAEVCFFSFFQDSWILSGHL*P
QPCSEGALSLCLLLMSAVEGSHTLVSHFRGSRC
PGRPKKESG*GAVKVRREDNSVNSVTLKIFENSI
VKQLLKEITKFSNE*AVPPTSVLPDRRASMFTL
FKLGGKI*TFLSS*FKKYICIYCIFTFSFR*R*
FQSKYSYFKKFPFPKNLLGTLTYF*SCVGAHLVP
*CVSSPLVGSYKAHGYKQW*DCSRGPAGHTHTP
KMYLDLGTPSQDPCTHVPVS*LEHFTLFPQPCS
PWEHTLGAALGQAREALPCAAQGLCAPHEHISLW
PGGLQAGCGNSS*GN*RFYEL*EY*RPGCWHQN
LKR*LDVSVLYVSGYQDASVQKVCLPWVYVFTF
FKKHFCRKNN*IPFLETYCRFCALTTSPYVRFVK
SVL*LNTETQ*THTK*FHE*FFRCPSQLVS*SR
ILGVGVAEKSSLKFLLIKKI*WNTIVCRFPFLM
YIL*VFIRFVGHITYQLSQMSVCNCVSFTL*NFV
QHK*VKKSLFFSTFSKSRIVNIVDSFSV*CVLL
FHNAVTCRNIVYLFSAYLMS*FLKSINIPVSHS
PAVP*S*LLRVVGGDWRAHCRPRGPPGWLSTFGS
WYFQSSGFQFLGFAALMMKCVFDASEKLSLAGY
KILLQEIPSNLLFVPKQLAYHASKFC*LQALSL
GKQKNQSIISRWERFFY*KFIPDNSAFRKEIKCA
TSRGAALQLFRARARQDK*MGGTGGSCLRTTSG
H*PLVDNCE*LGFPPPAVQLPVL*GWTNLSSGA
N*LYSPPHAPPIRSLHLVSLLLQVDALLLILHLL
QGRLGPHWTGCQDVKAYGSFKETSWWFHAGGSA
IPADLAWCLCVSTHVHVGWGKRVYR*R*ISWGL
L*TALCVRSILKLPVK*LDYFYLGISDYRSSLMF
YVQIL*PLVTVSELIRYPLINSTDLAVY*SITN
LFSRTQRM*HLYCSFPGLLVFCTDEF*QGNCHF
TCAILL*ITADF*TIFYVNFIKIKLSTSF

Frame 2

RLVCSLLELCVQRRCRCRRRRRRRRRRRRRHYH
HLILAATLRTLPHCDRIIAVFGSLRSRRHRLGA
LSWPLFPQMSDSDSRTEKRKKKRPNGKATF*CK
F*V*PRR*TIAACGEASPAQTWGPYLPTDRATR*
S*RQSRR*RGQLPPRQPSGPAGPTCQPWPFCYQ
IPAFHLYEKILPAVSILQWVFLF*HRQEPSTHE
L*QINTNPKSSLPGLQPLSQCNGFHEAG*TCRYA
PRDMDRPRVAAYWRRV*RLLCKEGIFE*LPSSR
RPPTNGYLTTVTLHCPPGVENALTGSLRSRDTM
QTFCLFKPTRPSTAVSWCHYYAASGSLVEGAGDV
SEDTELDGTTFLFITTQQNF*WKFVVNVKEGAF
FAF*YTNHGFLEQDFV*EWCLHAVCFPPHLQ*G
FSKRKWKLFNQFVNNFCIKILRTYGLFSEDYVTP
AVETEPANLKSCLSLFLEITEFLNRETCDILPP
FPTIASLTFLNYF*YQKSSFEMELIKRAEGLLP
ACIDIPVPFVNIYVPL*IQLHLWQNFRLFLRLSS
SLFVMQLQSGLRCIDLVQCIFMIK*N*VRTRVN
ICLYLAQFERSVINWEAFGVGFHSISTSMLLGS
ILKRQ*Q**QQT*VLRPFVLLAFLVAGFPMVTGC
TVSIRSQRATVSITAESSCSIQLTPSWELAQAW
GRASDGHLLGLLHFSPTHSPLASLL*IHFETGL
IPLPPAP*KNNSGQKSVFFHFSRTVGYCQATCDP
SHVVRVLFLCACSL*VQWKEATHWSVISEAADA
QGDPRKSQVREQ*K*GGKTIL*TL*LLKFLKTP
SLNNF*KK*LNFQMSKQCHQLVFCPIEEPACSRY
LN*VEKSKHFYLHNLKNIYVYIAYSLFPLGRDD
FNPNTLTLKNFLSPRISLGL*LIFKAVLELILF
PDVSRAHW*GHTKPTVTSSGRIAAVGLLDTHIHQ
RCIWIWAPPPRIPVLTCQSPD*STLLCFLSPAA
PGSTHWVQPWARHGRPCPVLPRGCVHHMSTFPS
GLAASRLAVETVPEEIRDSMNCRSIKDQAVGTRT
*SDDWMSLYCMYLVIKMPLCRKYASRGYTFLPF
LKNIFVEKIIKSPFWKLTAGFVP*QPLPM*GL*
KVSCDLTQKRNKHTQNSFMSDSSDALPNWLVDQE
FWGWGLRRNQV*NSF*LKKYSGIQLSAVSPS*C
IYCEYLLDS*VILLIN*AKCLCAIVFPLPCKIL
YSINK*KNHCFSQLFQNQGL*IL*ILFLCDVSYC
FIML*LVEILYIYFLLI*CLNF*KVLTSLSPTP
LPSHEVNS*ELSGVTGELIADHVVLQGGSPPSG
PGISSQVGFNSWALPPL**SVCLMPVRNSVWQAT
KFYSKKYPATFCLFQSN*LIMQANFADSRLYL*
ENKKTKVLSAGGKDFSIENLSLTTQRLEKK*NV
PLPEVLHCSCSGLGPGRTSEWVGQVAPA*GPPQA
TNPLWTTVSSWVFPHLLCNFLCFEVGLTCLQEL
INCTALPTPHPYGHCIWSACFFRSMPSF*YSIS
FRGGWGPTGLGVKM*KLMGALRRLHGGSMQVVLP
SLLI*PGACVCPLTYTWGGGNVSTDDAKSVGVY
SKQHCV*EASSSSQLSNLTTFIWEFQTIEALLC
FMSRFCDH*LLYQNSSGTHL*IALIWLYTDPSLT
CFLGPSVCSICIAVSLAYLCFALMNFDRVIATL
LVQYCCK*LQIFKQSFMLIL*K*NFQLV

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