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Sequences

Sequence BCL2L11.iAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGTCTCACTCTGTCACCCAGGCTGGAGTGCACTGGTGCGATCTTGGCTCACTGCAACCTCCAACTCCCAAGT
TCAAGCGGTTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCC
AAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTAT
CTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAAC
CAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGA
TGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAAC
CATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAAC
TTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGC
TAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTG
ACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCC
CATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACT
CCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAG
TTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGT
AATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCA
GAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCAT
TTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCAT
AGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCT
CTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGT
CAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGA
AATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATC
TAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACT
TTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATT
GGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGC
ACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTG
CAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGG
CTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTC
TCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAA
AAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACAC
AGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCG
GAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTA
GATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAA
ATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGT
AGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAAC
TCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGG
GTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATA
CCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTA
TTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATT
GCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAAC
TGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCC
ACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCA
CTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGG
TGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAA
GAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACC
ACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGT
ATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAA
TAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQVSLCHPGWSALVRSWLTATSNSQV
QAVLLPQPPK*LGLQLP*GRLNLQICAQRYGSP
KSCGVLETSLTLTMQGGYF*IITKQPKTTHEWL
SYDCYVTLSAWCGECIDRFFAEPRYHADILLVQT
NKTQHRGLLVPLLCSQRFSCGGGR*RFRRHRAG
WDYLSVHHHTAEFLMEVCCECKGGSILCFLIYK
PWFFGAGFCVRMVFTCSVFSPSPSIRFFKKEMET
F*PICE*LLY*NFKNLRPILRGLCNPCSGN*AS
*LKKLP*FIFRDYRIFKQGDV*YTPSLPYYCLS
DLFKLFLIPKEFF*NGTD*KGRGSVASLH*YTSP
ICKYLRTFINSVASVAKFQTIFASFLITFCDAT
PVWTQMHRFGPVYFHDKVKLSQNKS*YLPVSCT
VRAICY*LGSIWCWFSFHFDEHVIGKYSEEAIAV
ITTDLSATPLCAAGFSGCRLSHGHRMHCQHQVP
EGHRVHYSRVQLQHPAHALMGIGTGLGQGF*WP
FAWPPAF*SNSQSTSFTPLNSL*NRPHPTSTSTI
EE*FWAEVCFFSFFQDSWILSGHL*PQPCSEGA
LSLCLLLMSAVEGSHTLVSHFRGSRCPGRPKKE
SG*GAVKVRREDNSVNSVTLKIFENSIVKQLLKE
ITKFSNE*AVPPTSVLPDRRASMFTLFKLGGKI
*TFLSS*FKKYICIYCIFTFSFR*R*FQSKYSY
FKKFPFPKNLLGTLTYF*SCVGAHLVP*CVSSPL
VGSYKAHGYKQW*DCSRGPAGHTHTPKMYLDLG
TPSQDPCTHVPVS*LEHFTLFPQPCSPWEHTLG
AALGQAREALPCAAQGLCAPHEHISLWPGGLQAG
CGNSS*GN*RFYEL*EY*RPGCWHQNLKR*LDV
SVLYVSGYQDASVQKVCLPWVYVFTFFKKHFCR
KNN*IPFLETYCRFCALTTSPYVRFVKSVL*LNT
ETQ*THTK*FHE*FFRCPSQLVS*SRILGVGVA
EKSSLKFLLIKKI*WNTIVCRFPFLMYIL*VFI
RFVGHITYQLSQMSVCNCVSFTL*NFVQHK*VKK
SLFFSTFSKSRIVNIVDSFSV*CVLLFHNAVTC
RNIVYLFSAYLMS*FLKSINIPVSHSPAVP*S*
LLRVVGGDWRAHCRPRGPPGWLSTFGSWYFQSSG
FQFLGFAALMMKCVFDASEKLSLAGYKILLQEI
PSNLLFVPKQLAYHASKFC*LQALSLGKQKNQS
IISRWERFFY*KFIPDNSAFRKEIKCATSRGAAL
QLFRARARQDK*MGGTGGSCLRTTSGH*PLVDN
CE*LGFPPPAVQLPVL*GWTNLSSGAN*LYSPP
HAPPIRSLHLVSLLLQVDALLLILHLLQGRLGPH
WTGCQDVKAYGSFKETSWWFHAGGSAIPADLAW
CLCVSTHVHVGWGKRVYR*R*ISWGLL*TALCV
RSILKLPVK*LDYFYLGISDYRSSLMFYVQIL*P
LVTVSELIRYPLINSTDLAVY*SITNLFSRTQR
M*HLYCSFPGLLVFCTDEF*QGNCHFTCAILL*
ITADF*TIFYVNFIKIKLSTSF

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKSHSVTQAGVHWCDLGSLQPPTPK
FKRFSCLSLPSSWDYSFHEAG*TCRYAPRDMDRP
RVAAYWRRV*RLLCKEGIFE*LPSSRRPPTNGY
LTTVTLHCPPGVENALTGSLRSRDTMQTFCLFK
PTRPSTAVSWCHYYAASGSLVEGAGDVSEDTELD
GTTFLFITTQQNF*WKFVVNVKEGAFFAF*YTN
HGFLEQDFV*EWCLHAVCFPPHLQ*GFSKRKWK
LFNQFVNNFCIKILRTYGLFSEDYVTPAVETEPA
NLKSCLSLFLEITEFLNRETCDILPPFPTIASL
TFLNYF*YQKSSFEMELIKRAEGLLPACIDIPV
PFVNIYVPL*IQLHLWQNFRLFLRLSSSLFVMQL
QSGLRCIDLVQCIFMIK*N*VRTRVNICLYLAQ
FERSVINWEAFGVGFHSISTSMLLGSILKRQ*Q
**QQT*VLRPFVLLAFLVAGFPMVTGCTVSIRSQ
RATVSITAESSCSIQLTPSWELAQAWGRASDGH
LLGLLHFSPTHSPLASLL*IHFETGLIPLPPAP
*KNNSGQKSVFFHFSRTVGYCQATCDPSHVVRVL
FLCACSL*VQWKEATHWSVISEAADAQGDPRKS
QVREQ*K*GGKTIL*TL*LLKFLKTPSLNNF*K
K*LNFQMSKQCHQLVFCPIEEPACSRYLN*VEKS
KHFYLHNLKNIYVYIAYSLFPLGRDDFNPNTLT
LKNFLSPRISLGL*LIFKAVLELILFPDVSRAH
W*GHTKPTVTSSGRIAAVGLLDTHIHQRCIWIWA
PPPRIPVLTCQSPD*STLLCFLSPAAPGSTHWV
QPWARHGRPCPVLPRGCVHHMSTFPSGLAASRL
AVETVPEEIRDSMNCRSIKDQAVGTRT*SDDWMS
LYCMYLVIKMPLCRKYASRGYTFLPFLKNIFVE
KIIKSPFWKLTAGFVP*QPLPM*GL*KVSCDLT
QKRNKHTQNSFMSDSSDALPNWLVDQEFWGWGLR
RNQV*NSF*LKKYSGIQLSAVSPS*CIYCEYLL
DS*VILLIN*AKCLCAIVFPLPCKILYSINK*K
NHCFSQLFQNQGL*IL*ILFLCDVSYCFIML*LV
EILYIYFLLI*CLNF*KVLTSLSPTPLPSHEVN
S*ELSGVTGELIADHVVLQGGSPPSGPGISSQV
GFNSWALPPL**SVCLMPVRNSVWQATKFYSKKY
PATFCLFQSN*LIMQANFADSRLYL*ENKKTKV
LSAGGKDFSIENLSLTTQRLEKK*NVPLPEVLH
CSCSGLGPGRTSEWVGQVAPA*GPPQATNPLWTT
VSSWVFPHLLCNFLCFEVGLTCLQELINCTALP
TPHPYGHCIWSACFFRSMPSF*YSISFRGGWGP
TGLGVKM*KLMGALRRLHGGSMQVVLPSLLI*PG
ACVCPLTYTWGGGNVSTDDAKSVGVYSKQHCV*
EASSSSQLSNLTTFIWEFQTIEALLCFMSRFCD
H*LLYQNSSGTHL*IALIWLYTDPSLTCFLGPSV
CSICIAVSLAYLCFALMNFDRVIATLLVQYCCK
*LQIFKQSFMLIL*K*NFQLV

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATSLTLSPRLECTGAILAHCNLQLPS
SSGSPASASQVAGITASMRQAEPADMRPEIWIA
QELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVI
LRLLRYIVRLVWRMH*QVLCGAEIPCRHFACSN
QQDPAPRSPGAIIMQPAVLLWRGQVTFQKTPSW
MGLPFCSSPHSRISNGSLL*M*RREHSLLFNIQT
MVFWSRILCKNGVYMQCVFPLTFNKVFQKGNGN
FLTNL*ITFVLKF*EPTAYSQRIM*PLQWKLSQ
LT*KAALVYF*RLQNF*TGRRVIYSLPSLLLPL*
PF*IIFNTKRVLLKWN*LKGQRVCCQPALIYQS
HL*IFTYLYKFSCICGKISDYFCVFPHHFL*CN
SSLDSDA*IWSSVFS**SEIESEQELISACILHS
SSDLLLTGKHLVLVFIPFRRACYWEVF*RGNSS
NNNRLKCYAPLCCWLFWLQAFPWSQDALSASGP
RGPPCPLQQSPAAASSSRPHGNWHRPGAGLLMAI
CLASCILVQLTVH*LHSFKFTLKQASSHFHQHH
RRIILGRSLFFFIFPGQLDIVRPLVTPAM**GC
SFSVPAPYECSGRKPHTGQSFQRQQMPRETQERV
RLGSSESEEGRQFCELCNS*NF*KLHR*TTFKR
NN*IFK*VSSATN*CFAR*KSQHVHVI*IRWKN
LNIFIFII*KIYMYILHIHFFL*VEMISIQILLL
*KISFPQESPWDFDLFLKLCWSSSCSLMCLEPI
GRVIQSPRLQAVVGLQPWACWTHTYTKDVFGSG
HPLPGSLYSRASLLTRALYSVSSALQPLGAHTGC
SPGPGTGGPALCCPGAVCTT*AHFPLAWRPPGW
LWKQFLRKLEIL*IVGVLKTRLLAPELKAMTGC
LCTVCIWLSRCLCAESMPPVGIRFYLF*KTFL*K
K*LNPLFGNLLQVLCLDNLSLCEVCKKCPVT*H
RNAINTHKIVS*VILQMPFPTG*LIKNFGGGGC
GEIKFKIPSD*KNIVEYNCLPFPLLNVYIVSIY*
IRRSYYLSTEPNVCVQLCFLYLVKFCTA*ISKK
ITVFLNFFKIKDCKYCRFFFCVMCPTVS*CCNL
*KYCIFIFCLFNVLISEKY*HPCLPLPCRPMKLT
PESCRG*LESSLQTTWSSRVALHLRVLVFPVKW
VSILGLCRPYDEVCV*CQ*ETQSGRLQNSTPRN
TQQPSVCSKATSLSCKQILLTPGFIFRKTKKPKY
YQQVGKIFLLKIYP*QLSV*KRNKMCHFQRCCI
AVVQG*GQAGQVNGWDRWLLPKDHLRPLTPCGQ
L*VAGFSPTCCATSCALRLD*LVFRS*LTVQPSP
RPTHTVTAFGQPASSGRCPPSDTPSPSGEVGAP
LDWVSRCESLWEL*GDFMVVPCRWFCHPC*FSL
VPVCVHSRTRGVGETCLQMTLNQLGSTLNSIVCK
KHPQAPS*VT*LLLFGNFRL*KLSYVLCPDSVT
TSYCIRTHQVPTYK*H*SGCILIHH*PVF*DPA
YVAFVLQFPWLTCVLH**ILTG*LPLYLCNTAVN
NCRFLNNLLC*FYKNKTFN*F

Sequence BCL2L11.cAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAG
GAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGACGGAGCTGTGGAGGCTGAAT
CCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACAT
TGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGG
TCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCAT
CACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGAT
TTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATA
ACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAG
TTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAA
TACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTAC
CTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCAT
AGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAAC
TGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGC
TACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTAC
AGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTT
AGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGA
AGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTT
ATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAG
TGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGA
GTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAA
TTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCA
AGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCA
CGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGT
ACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGG
AGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGG
AAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGT
TATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTT
TGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACAC
AAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTC
CTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTT
ATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTT
TTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTT
TCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTG
ACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGC
CGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTT
CCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGAT
TTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGC
CAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCC
CCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCAC
TGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGT
GAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCAC
GTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAG
TTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACT
CATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGT
TTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAA
TCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYAR
RLEK*RKLSCSCHVFSPLKGSGEAFETELWRLN
P*RRR*ERHRYF*IITKQPKTTHEWLSYDCYVT
LSAWCGECIDRFFAEPRYHADILLVQTNKTQHRG
LLVPLLCSQRFSCGGGR*RFRRHRAGWDYLSVH
HHTAEFLMEVCCECKGGSILCFLIYKPWFFGAG
FCVRMVFTCSVFSPSPSIRFFKKEMETF*PICE*
LLY*NFKNLRPILRGLCNPCSGN*AS*LKKLP*
FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKLFL
IPKEFF*NGTD*KGRGSVASLH*YTSPICKYLRT
FINSVASVAKFQTIFASFLITFCDATPVWTQMH
RFGPVYFHDKVKLSQNKS*YLPVSCTVRAICY*
LGSIWCWFSFHFDEHVIGKYSEEAIAVITTDLSA
TPLCAAGFSGCRLSHGHRMHCQHQVPEGHRVHY
SRVQLQHPAHALMGIGTGLGQGF*WPFAWPPAF
*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*FWAE
VCFFSFFQDSWILSGHL*PQPCSEGALSLCLLL
MSAVEGSHTLVSHFRGSRCPGRPKKESG*GAVK
VRREDNSVNSVTLKIFENSIVKQLLKEITKFSNE
*AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS*
FKKYICIYCIFTFSFR*R*FQSKYSYFKKFPFP
KNLLGTLTYF*SCVGAHLVP*CVSSPLVGSYKAH
GYKQW*DCSRGPAGHTHTPKMYLDLGTPSQDPC
THVPVS*LEHFTLFPQPCSPWEHTLGAALGQAR
EALPCAAQGLCAPHEHISLWPGGLQAGCGNSS*G
N*RFYEL*EY*RPGCWHQNLKR*LDVSVLYVSG
YQDASVQKVCLPWVYVFTFFKKHFCRKNN*IPF
LETYCRFCALTTSPYVRFVKSVL*LNTETQ*THT
K*FHE*FFRCPSQLVS*SRILGVGVAEKSSLKF
LLIKKI*WNTIVCRFPFLMYIL*VFIRFVGHIT
YQLSQMSVCNCVSFTL*NFVQHK*VKKSLFFSTF
SKSRIVNIVDSFSV*CVLLFHNAVTCRNIVYLF
SAYLMS*FLKSINIPVSHSPAVP*S*LLRVVGG
DWRAHCRPRGPPGWLSTFGSWYFQSSGFQFLGFA
ALMMKCVFDASEKLSLAGYKILLQEIPSNLLFV
PKQLAYHASKFC*LQALSLGKQKNQSIISRWER
FFY*KFIPDNSAFRKEIKCATSRGAALQLFRARA
RQDK*MGGTGGSCLRTTSGH*PLVDNCE*LGFP
PPAVQLPVL*GWTNLSSGAN*LYSPPHAPPIRS
LHLVSLLLQVDALLLILHLLQGRLGPHWTGCQDV
KAYGSFKETSWWFHAGGSAIPADLAWCLCVSTH
VHVGWGKRVYR*R*ISWGLL*TALCVRSILKLP
VK*LDYFYLGISDYRSSLMFYVQIL*PLVTVSEL
IRYPLINSTDLAVY*SITNLFSRTQRM*HLYCS
FPGLLVFCTDEF*QGNCHFTCAILL*ITADF*T
IFYVNFIKIKLSTSF

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LP*GRLNLQICAQRYGSPKSCGVLETSLTLTMQ
GG*RNRGSCRVVVMYSVHLRAVGKRLRRSCGG*I
LEGGGERGTGIFE*LPSSRRPPTNGYLTTVTLH
CPPGVENALTGSLRSRDTMQTFCLFKPTRPSTA
VSWCHYYAASGSLVEGAGDVSEDTELDGTTFLFI
TTQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQD
FV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVN
NFCIKILRTYGLFSEDYVTPAVETEPANLKSCLS
LFLEITEFLNRETCDILPPFPTIASLTFLNYF*
YQKSSFEMELIKRAEGLLPACIDIPVPFVNIYV
PL*IQLHLWQNFRLFLRLSSSLFVMQLQSGLRCI
DLVQCIFMIK*N*VRTRVNICLYLAQFERSVIN
WEAFGVGFHSISTSMLLGSILKRQ*Q**QQT*V
LRPFVLLAFLVAGFPMVTGCTVSIRSQRATVSIT
AESSCSIQLTPSWELAQAWGRASDGHLLGLLHF
SPTHSPLASLL*IHFETGLIPLPPAP*KNNSGQ
KSVFFHFSRTVGYCQATCDPSHVVRVLFLCACSL
*VQWKEATHWSVISEAADAQGDPRKSQVREQ*K
*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNFQM
SKQCHQLVFCPIEEPACSRYLN*VEKSKHFYLHN
LKNIYVYIAYSLFPLGRDDFNPNTLTLKNFLSP
RISLGL*LIFKAVLELILFPDVSRAHW*GHTKP
TVTSSGRIAAVGLLDTHIHQRCIWIWAPPPRIPV
LTCQSPD*STLLCFLSPAAPGSTHWVQPWARHG
RPCPVLPRGCVHHMSTFPSGLAASRLAVETVPE
EIRDSMNCRSIKDQAVGTRT*SDDWMSLYCMYLV
IKMPLCRKYASRGYTFLPFLKNIFVEKIIKSPF
WKLTAGFVP*QPLPM*GL*KVSCDLTQKRNKHT
QNSFMSDSSDALPNWLVDQEFWGWGLRRNQV*NS
F*LKKYSGIQLSAVSPS*CIYCEYLLDS*VILL
IN*AKCLCAIVFPLPCKILYSINK*KNHCFSQL
FQNQGL*IL*ILFLCDVSYCFIML*LVEILYIYF
LLI*CLNF*KVLTSLSPTPLPSHEVNS*ELSGV
TGELIADHVVLQGGSPPSGPGISSQVGFNSWAL
PPL**SVCLMPVRNSVWQATKFYSKKYPATFCLF
QSN*LIMQANFADSRLYL*ENKKTKVLSAGGKD
FSIENLSLTTQRLEKK*NVPLPEVLHCSCSGLG
PGRTSEWVGQVAPA*GPPQATNPLWTTVSSWVFP
HLLCNFLCFEVGLTCLQELINCTALPTPHPYGH
CIWSACFFRSMPSF*YSISFRGGWGPTGLGVKM
*KLMGALRRLHGGSMQVVLPSLLI*PGACVCPLT
YTWGGGNVSTDDAKSVGVYSKQHCV*EASSSSQ
LSNLTTFIWEFQTIEALLCFMSRFCDH*LLYQN
SSGTHL*IALIWLYTDPSLTCFLGPSVCSICIAV
SLAYLCFALMNFDRVIATLLVQYCCK*LQIFKQ
SFMLIL*K*NFQLV

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
FHEAG*TCRYAPRDMDRPRVAAYWRRV*RLLCK
EVREIEEVVV*LSCIQST*GQWGSV*DGAVEAE
SLKEEVREAQVFLNNYQAAEDHPRMVILRLLRYI
VRLVWRMH*QVLCGAEIPCRHFACSNQQDPAPR
SPGAIIMQPAVLLWRGQVTFQKTPSWMGLPFCS
SPHSRISNGSLL*M*RREHSLLFNIQTMVFWSRI
LCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*I
TFVLKF*EPTAYSQRIM*PLQWKLSQLT*KAAL
VYF*RLQNF*TGRRVIYSLPSLLLPL*PF*IIFN
TKRVLLKWN*LKGQRVCCQPALIYQSHL*IFTY
LYKFSCICGKISDYFCVFPHHFL*CNSSLDSDA
*IWSSVFS**SEIESEQELISACILHSSSDLLLT
GKHLVLVFIPFRRACYWEVF*RGNSSNNNRLKC
YAPLCCWLFWLQAFPWSQDALSASGPRGPPCPL
QQSPAAASSSRPHGNWHRPGAGLLMAICLASCIL
VQLTVH*LHSFKFTLKQASSHFHQHHRRIILGR
SLFFFIFPGQLDIVRPLVTPAM**GCSFSVPAP
YECSGRKPHTGQSFQRQQMPRETQERVRLGSSES
EEGRQFCELCNS*NF*KLHR*TTFKRNN*IFK*
VSSATN*CFAR*KSQHVHVI*IRWKNLNIFIFI
I*KIYMYILHIHFFL*VEMISIQILLL*KISFPQ
ESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQSP
RLQAVVGLQPWACWTHTYTKDVFGSGHPLPGSL
YSRASLLTRALYSVSSALQPLGAHTGCSPGPGTG
GPALCCPGAVCTT*AHFPLAWRPPGWLWKQFLR
KLEIL*IVGVLKTRLLAPELKAMTGCLCTVCIW
LSRCLCAESMPPVGIRFYLF*KTFL*KK*LNPLF
GNLLQVLCLDNLSLCEVCKKCPVT*HRNAINTH
KIVS*VILQMPFPTG*LIKNFGGGGCGEIKFKI
PSD*KNIVEYNCLPFPLLNVYIVSIY*IRRSYYL
STEPNVCVQLCFLYLVKFCTA*ISKKITVFLNF
FKIKDCKYCRFFFCVMCPTVS*CCNL*KYCIFI
FCLFNVLISEKY*HPCLPLPCRPMKLTPESCRG*
LESSLQTTWSSRVALHLRVLVFPVKWVSILGLC
RPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVC
SKATSLSCKQILLTPGFIFRKTKKPKYYQQVGKI
FLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*G
QAGQVNGWDRWLLPKDHLRPLTPCGQL*VAGFS
PTCCATSCALRLD*LVFRS*LTVQPSPRPTHTVT
AFGQPASSGRCPPSDTPSPSGEVGAPLDWVSRC
ESLWEL*GDFMVVPCRWFCHPC*FSLVPVCVHS
RTRGVGETCLQMTLNQLGSTLNSIVCKKHPQAPS
*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIRT
HQVPTYK*H*SGCILIHH*PVF*DPAYVAFVLQ
FPWLTCVLH**ILTG*LPLYLCNTAVNNCRFLNN
LLC*FYKNKTFN*F

Sequence BCL2L11.bAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAG
GAGGATGCCTCTTCCACCTGATTAAGAACCACTGTAGCAGACGCAGACTTATTGGACACTAGGCGGGAGGCCAGCTCTGCAGACAGCAGGTCTCAGGAAG
ACGGTCAAGGCATGGCTGCTGATGATCCGCTTATGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTAC
GTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGC
ACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTC
TGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGA
GCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTT
GTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCT
GCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTA
TTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATT
TACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCA
GATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGT
TATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACT
TAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGT
CCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCT
GCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCT
GGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCT
GCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCA
GTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTT
CAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATC
TTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCT
TTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACA
AAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGA
TCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAG
GCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTT
CCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGT
ATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATC
CCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAA
CACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTT
AAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCAT
ATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCT
CAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATA
TTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTC
GGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGG
GCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCT
GTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGG
GAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGG
CTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGG
TTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATA
CGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTC
AAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTC
CACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAG
CTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTAT
CAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTA
TTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTT
TAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYAR
RMPLPPD*EPL*QTQTYWTLGGRPALQTAGLRK
TVKAWLLMIRLWVFLNNYQAAEDHPRMVILRLL
RYIVRLVWRMH*QVLCGAEIPCRHFACSNQQDPA
PRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPF
CSSPHSRISNGSLL*M*RREHSLLFNIQTMVFW
SRILCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL
*ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KA
ALVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*I
IFNTKRVLLKWN*LKGQRVCCQPALIYQSHL*IF
TYLYKFSCICGKISDYFCVFPHHFL*CNSSLDS
DA*IWSSVFS**SEIESEQELISACILHSSSDL
LLTGKHLVLVFIPFRRACYWEVF*RGNSSNNNRL
KCYAPLCCWLFWLQAFPWSQDALSASGPRGPPC
PLQQSPAAASSSRPHGNWHRPGAGLLMAICLAS
CILVQLTVH*LHSFKFTLKQASSHFHQHHRRIIL
GRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVP
APYECSGRKPHTGQSFQRQQMPRETQERVRLGS
SESEEGRQFCELCNS*NF*KLHR*TTFKRNN*IF
K*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFI
FII*KIYMYILHIHFFL*VEMISIQILLL*KIS
FPQESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQ
SPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPG
SLYSRASLLTRALYSVSSALQPLGAHTGCSPGP
GTGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQF
LRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVC
IWLSRCLCAESMPPVGIRFYLF*KTFL*KK*LN
PLFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAIN
THKIVS*VILQMPFPTG*LIKNFGGGGCGEIKF
KIPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRS
YYLSTEPNVCVQLCFLYLVKFCTA*ISKKITVFL
NFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCI
FIFCLFNVLISEKY*HPCLPLPCRPMKLTPESC
RG*LESSLQTTWSSRVALHLRVLVFPVKWVSILG
LCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPS
VCSKATSLSCKQILLTPGFIFRKTKKPKYYQQV
GKIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG
*GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAG
FSPTCCATSCALRLD*LVFRS*LTVQPSPRPTH
TVTAFGQPASSGRCPPSDTPSPSGEVGAPLDWVS
RCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCV
HSRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQ
APS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCI
RTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFV
LQFPWLTCVLH**ILTG*LPLYLCNTAVNNCRF
LNNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LP*GRLNLQICAQRYGSPKSCGVLETSLTLTMQ
GGCLFHLIKNHCSRRRLIGH*AGGQLCRQQVSGR
RSRHGC**SAYGYF*IITKQPKTTHEWLSYDCY
VTLSAWCGECIDRFFAEPRYHADILLVQTNKTQ
HRGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYLS
VHHHTAEFLMEVCCECKGGSILCFLIYKPWFFG
AGFCVRMVFTCSVFSPSPSIRFFKKEMETF*PI
CE*LLY*NFKNLRPILRGLCNPCSGN*AS*LKKL
P*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKL
FLIPKEFF*NGTD*KGRGSVASLH*YTSPICKY
LRTFINSVASVAKFQTIFASFLITFCDATPVWTQ
MHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAIC
Y*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTD
LSATPLCAAGFSGCRLSHGHRMHCQHQVPEGHRV
HYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPP
AF*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*F
WAEVCFFSFFQDSWILSGHL*PQPCSEGALSLCL
LLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GA
VKVRREDNSVNSVTLKIFENSIVKQLLKEITKF
SNE*AVPPTSVLPDRRASMFTLFKLGGKI*TFLS
S*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFP
FPKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSY
KAHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQD
PCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQ
AREALPCAAQGLCAPHEHISLWPGGLQAGCGNS
S*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLYV
SGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*I
PFLETYCRFCALTTSPYVRFVKSVL*LNTETQ*
THTK*FHE*FFRCPSQLVS*SRILGVGVAEKSSL
KFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGH
ITYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFF
STFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIVY
LFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVV
GGDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFL
GFAALMMKCVFDASEKLSLAGYKILLQEIPSNLL
FVPKQLAYHASKFC*LQALSLGKQKNQSIISRW
ERFFY*KFIPDNSAFRKEIKCATSRGAALQLFR
ARARQDK*MGGTGGSCLRTTSGH*PLVDNCE*LG
FPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPI
RSLHLVSLLLQVDALLLILHLLQGRLGPHWTGC
QDVKAYGSFKETSWWFHAGGSAIPADLAWCLCVS
THVHVGWGKRVYR*R*ISWGLL*TALCVRSILK
LPVK*LDYFYLGISDYRSSLMFYVQIL*PLVTV
SELIRYPLINSTDLAVY*SITNLFSRTQRM*HLY
CSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF
*TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
FHEAG*TCRYAPRDMDRPRVAAYWRRV*RLLCK
EDASST*LRTTVADADLLDTRREASSADSRSQE
DGQGMAADDPLMGIFE*LPSSRRPPTNGYLTTVT
LHCPPGVENALTGSLRSRDTMQTFCLFKPTRPS
TAVSWCHYYAASGSLVEGAGDVSEDTELDGTTF
LFITTQQNF*WKFVVNVKEGAFFAF*YTNHGFLE
QDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQF
VNNFCIKILRTYGLFSEDYVTPAVETEPANLKS
CLSLFLEITEFLNRETCDILPPFPTIASLTFLNY
F*YQKSSFEMELIKRAEGLLPACIDIPVPFVNI
YVPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGL
RCIDLVQCIFMIK*N*VRTRVNICLYLAQFERSV
INWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT
*VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATV
SITAESSCSIQLTPSWELAQAWGRASDGHLLGLL
HFSPTHSPLASLL*IHFETGLIPLPPAP*KNNS
GQKSVFFHFSRTVGYCQATCDPSHVVRVLFLCA
CSL*VQWKEATHWSVISEAADAQGDPRKSQVREQ
*K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNF
QMSKQCHQLVFCPIEEPACSRYLN*VEKSKHFY
LHNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNFL
SPRISLGL*LIFKAVLELILFPDVSRAHW*GHT
KPTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPR
IPVLTCQSPD*STLLCFLSPAAPGSTHWVQPWAR
HGRPCPVLPRGCVHHMSTFPSGLAASRLAVETV
PEEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCM
YLVIKMPLCRKYASRGYTFLPFLKNIFVEKIIKS
PFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNK
HTQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV
*NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*VI
LLIN*AKCLCAIVFPLPCKILYSINK*KNHCFS
QLFQNQGL*IL*ILFLCDVSYCFIML*LVEILY
IYFLLI*CLNF*KVLTSLSPTPLPSHEVNS*ELS
GVTGELIADHVVLQGGSPPSGPGISSQVGFNSW
ALPPL**SVCLMPVRNSVWQATKFYSKKYPATF
CLFQSN*LIMQANFADSRLYL*ENKKTKVLSAGG
KDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSG
LGPGRTSEWVGQVAPA*GPPQATNPLWTTVSSW
VFPHLLCNFLCFEVGLTCLQELINCTALPTPHPY
GHCIWSACFFRSMPSF*YSISFRGGWGPTGLGV
KM*KLMGALRRLHGGSMQVVLPSLLI*PGACVC
PLTYTWGGGNVSTDDAKSVGVYSKQHCV*EASSS
SQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLY
QNSSGTHL*IALIWLYTDPSLTCFLGPSVCSIC
IAVSLAYLCFALMNFDRVIATLLVQYCCK*LQIF
KQSFMLIL*K*NFQLV

Sequence BCL2L11.aAug05

GCCGCCTGGTCTGCAGTTTGTTGGAGCTCTGCGTCCAGCGCCGCTGCCGCTGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACTACCA
CCACTTGATTCTTGCAGCCACCCTGCGAACCCTGCCACACTGCGATCGCATCATCGCGGTATTCGGTTCGCTGCGTTCCCGCCGCCACCGCCTCGGCGCC
CTTTCTTGGCCCTTGTTCCCCCAAATGTCTGACTCTGACTCTCGGACTGAGAAACGCAAGAAAAAAAGACCAAATGGCAAAGCAACCTTCTGATGTAAGT
TCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGGTA
ATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGCCCCACCTGCCAGCCCTGGCCCTTTTGCTACCAG
ATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCTTTTGACACAGACAGGAGCCCAGCACCCATGAGT
TGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGC
GCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGA
AGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGC
AGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGT
TTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTC
TTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTT
TTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCC
TGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCC
TTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAG
CCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTC
ATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAAT
ATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTA
TTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATG
CACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGG
GGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCA
TCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCC
CAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCC
CAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCAT
CGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTA
TTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGAT
TTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCC
CTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCA
AAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCC
CCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTG
GCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAAC
TTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTT
TTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAA
AAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGA
ATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGT
ATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGT
ACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTG
TTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCC
CTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTC
CTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTAC
AAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAG
GAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGC
CACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGC
CACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTA
ATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCT
TCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCC
ATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTAC
TCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTT
TTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAAC
CTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTA
CTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

AAWSAVCWSSASSAAAAAAAAAAAAAAAAAATT
TT*FLQPPCEPCHTAIASSRYSVRCVPAATASAP
FLGPCSPKCLTLTLGLRNARKKDQMAKQPSDVS
SECDREGRQLQPAERPPQLRPGAPTSLQTEPQG
NPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATR
SPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMS
CDKSTQTPSPPCQAFNHYLSAMASMRQAEPADM
RPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAE
DHPRMVILRLLRYIVRLVWRMH*QVLCGAEIPC
RHFACSNQQDPAPRSPGAIIMQPAVLLWRGQVT
FQKTPSWMGLPFCSSPHSRISNGSLL*M*RREHS
LLFNIQTMVFWSRILCKNGVYMQCVFPLTFNKV
FQKGNGNFLTNL*ITFVLKF*EPTAYSQRIM*P
LQWKLSQLT*KAALVYF*RLQNF*TGRRVIYSLP
SLLLPL*PF*IIFNTKRVLLKWN*LKGQRVCCQ
PALIYQSHL*IFTYLYKFSCICGKISDYFCVFP
HHFL*CNSSLDSDA*IWSSVFS**SEIESEQELI
SACILHSSSDLLLTGKHLVLVFIPFRRACYWEV
F*RGNSSNNNRLKCYAPLCCWLFWLQAFPWSQD
ALSASGPRGPPCPLQQSPAAASSSRPHGNWHRPG
AGLLMAICLASCILVQLTVH*LHSFKFTLKQAS
SHFHQHHRRIILGRSLFFFIFPGQLDIVRPLVT
PAM**GCSFSVPAPYECSGRKPHTGQSFQRQQMP
RETQERVRLGSSESEEGRQFCELCNS*NF*KLH
R*TTFKRNN*IFK*VSSATN*CFAR*KSQHVHV
I*IRWKNLNIFIFII*KIYMYILHIHFFL*VEMI
SIQILLL*KISFPQESPWDFDLFLKLCWSSSCS
LMCLEPIGRVIQSPRLQAVVGLQPWACWTHTYT
KDVFGSGHPLPGSLYSRASLLTRALYSVSSALQP
LGAHTGCSPGPGTGGPALCCPGAVCTT*AHFPL
AWRPPGWLWKQFLRKLEIL*IVGVLKTRLLAPE
LKAMTGCLCTVCIWLSRCLCAESMPPVGIRFYLF
*KTFL*KK*LNPLFGNLLQVLCLDNLSLCEVCK
KCPVT*HRNAINTHKIVS*VILQMPFPTG*LIK
NFGGGGCGEIKFKIPSD*KNIVEYNCLPFPLLNV
YIVSIY*IRRSYYLSTEPNVCVQLCFLYLVKFC
TA*ISKKITVFLNFFKIKDCKYCRFFFCVMCPT
VS*CCNL*KYCIFIFCLFNVLISEKY*HPCLPLP
CRPMKLTPESCRG*LESSLQTTWSSRVALHLRV
LVFPVKWVSILGLCRPYDEVCV*CQ*ETQSGRL
QNSTPRNTQQPSVCSKATSLSCKQILLTPGFIFR
KTKKPKYYQQVGKIFLLKIYP*QLSV*KRNKMC
HFQRCCIAVVQG*GQAGQVNGWDRWLLPKDHLR
PLTPCGQL*VAGFSPTCCATSCALRLD*LVFRS*
LTVQPSPRPTHTVTAFGQPASSGRCPPSDTPSP
SGEVGAPLDWVSRCESLWEL*GDFMVVPCRWFC
HPC*FSLVPVCVHSRTRGVGETCLQMTLNQLGST
LNSIVCKKHPQAPS*VT*LLLFGNFRL*KLSYV
LCPDSVTTSYCIRTHQVPTYK*H*SGCILIHH*
PVF*DPAYVAFVLQFPWLTCVLH**ILTG*LPLY
LCNTAVNNCRFLNNLLC*FYKNKTFN*F

Frame 1

PPGLQFVGALRPAPLPLPPPPPPPPPPPPPPLP
PLDSCSHPANPATLRSHHRGIRFAAFPPPPPRR
PFLALVPPNV*L*LSD*ETQEKKTKWQSNLLM*V
LSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKV
ILKAITEVKGTAAPTAALRARWPHLPALALLLP
DPRFSSL*EDPPCCLDPPVGISLLTQTGAQHP*V
VTNQHKPQVLLARPSTTISVQWLP*GRLNLQIC
AQRYGSPKSCGVLETSLTLTMQGGYF*IITKQP
KTTHEWLSYDCYVTLSAWCGECIDRFFAEPRYHA
DILLVQTNKTQHRGLLVPLLCSQRFSCGGGR*R
FRRHRAGWDYLSVHHHTAEFLMEVCCECKGGSI
LCFLIYKPWFFGAGFCVRMVFTCSVFSPSPSIRF
FKKEMETF*PICE*LLY*NFKNLRPILRGLCNP
CSGN*AS*LKKLP*FIFRDYRIFKQGDV*YTPS
LPYYCLSDLFKLFLIPKEFF*NGTD*KGRGSVAS
LH*YTSPICKYLRTFINSVASVAKFQTIFASFL
ITFCDATPVWTQMHRFGPVYFHDKVKLSQNKS*
YLPVSCTVRAICY*LGSIWCWFSFHFDEHVIGKY
SEEAIAVITTDLSATPLCAAGFSGCRLSHGHRM
HCQHQVPEGHRVHYSRVQLQHPAHALMGIGTGL
GQGF*WPFAWPPAF*SNSQSTSFTPLNSL*NRPH
PTSTSTIEE*FWAEVCFFSFFQDSWILSGHL*P
QPCSEGALSLCLLLMSAVEGSHTLVSHFRGSRC
PGRPKKESG*GAVKVRREDNSVNSVTLKIFENSI
VKQLLKEITKFSNE*AVPPTSVLPDRRASMFTL
FKLGGKI*TFLSS*FKKYICIYCIFTFSFR*R*
FQSKYSYFKKFPFPKNLLGTLTYF*SCVGAHLVP
*CVSSPLVGSYKAHGYKQW*DCSRGPAGHTHTP
KMYLDLGTPSQDPCTHVPVS*LEHFTLFPQPCS
PWEHTLGAALGQAREALPCAAQGLCAPHEHISLW
PGGLQAGCGNSS*GN*RFYEL*EY*RPGCWHQN
LKR*LDVSVLYVSGYQDASVQKVCLPWVYVFTF
FKKHFCRKNN*IPFLETYCRFCALTTSPYVRFVK
SVL*LNTETQ*THTK*FHE*FFRCPSQLVS*SR
ILGVGVAEKSSLKFLLIKKI*WNTIVCRFPFLM
YIL*VFIRFVGHITYQLSQMSVCNCVSFTL*NFV
QHK*VKKSLFFSTFSKSRIVNIVDSFSV*CVLL
FHNAVTCRNIVYLFSAYLMS*FLKSINIPVSHS
PAVP*S*LLRVVGGDWRAHCRPRGPPGWLSTFGS
WYFQSSGFQFLGFAALMMKCVFDASEKLSLAGY
KILLQEIPSNLLFVPKQLAYHASKFC*LQALSL
GKQKNQSIISRWERFFY*KFIPDNSAFRKEIKCA
TSRGAALQLFRARARQDK*MGGTGGSCLRTTSG
H*PLVDNCE*LGFPPPAVQLPVL*GWTNLSSGA
N*LYSPPHAPPIRSLHLVSLLLQVDALLLILHLL
QGRLGPHWTGCQDVKAYGSFKETSWWFHAGGSA
IPADLAWCLCVSTHVHVGWGKRVYR*R*ISWGL
L*TALCVRSILKLPVK*LDYFYLGISDYRSSLMF
YVQIL*PLVTVSELIRYPLINSTDLAVY*SITN
LFSRTQRM*HLYCSFPGLLVFCTDEF*QGNCHF
TCAILL*ITADF*TIFYVNFIKIKLSTSF

Frame 2

RLVCSLLELCVQRRCRCRRRRRRRRRRRRRHYH
HLILAATLRTLPHCDRIIAVFGSLRSRRHRLGA
LSWPLFPQMSDSDSRTEKRKKKRPNGKATF*CK
F*V*PRR*TIAACGEASPAQTWGPYLPTDRATR*
S*RQSRR*RGQLPPRQPSGPAGPTCQPWPFCYQ
IPAFHLYEKILPAVSILQWVFLF*HRQEPSTHE
L*QINTNPKSSLPGLQPLSQCNGFHEAG*TCRYA
PRDMDRPRVAAYWRRV*RLLCKEGIFE*LPSSR
RPPTNGYLTTVTLHCPPGVENALTGSLRSRDTM
QTFCLFKPTRPSTAVSWCHYYAASGSLVEGAGDV
SEDTELDGTTFLFITTQQNF*WKFVVNVKEGAF
FAF*YTNHGFLEQDFV*EWCLHAVCFPPHLQ*G
FSKRKWKLFNQFVNNFCIKILRTYGLFSEDYVTP
AVETEPANLKSCLSLFLEITEFLNRETCDILPP
FPTIASLTFLNYF*YQKSSFEMELIKRAEGLLP
ACIDIPVPFVNIYVPL*IQLHLWQNFRLFLRLSS
SLFVMQLQSGLRCIDLVQCIFMIK*N*VRTRVN
ICLYLAQFERSVINWEAFGVGFHSISTSMLLGS
ILKRQ*Q**QQT*VLRPFVLLAFLVAGFPMVTGC
TVSIRSQRATVSITAESSCSIQLTPSWELAQAW
GRASDGHLLGLLHFSPTHSPLASLL*IHFETGL
IPLPPAP*KNNSGQKSVFFHFSRTVGYCQATCDP
SHVVRVLFLCACSL*VQWKEATHWSVISEAADA
QGDPRKSQVREQ*K*GGKTIL*TL*LLKFLKTP
SLNNF*KK*LNFQMSKQCHQLVFCPIEEPACSRY
LN*VEKSKHFYLHNLKNIYVYIAYSLFPLGRDD
FNPNTLTLKNFLSPRISLGL*LIFKAVLELILF
PDVSRAHW*GHTKPTVTSSGRIAAVGLLDTHIHQ
RCIWIWAPPPRIPVLTCQSPD*STLLCFLSPAA
PGSTHWVQPWARHGRPCPVLPRGCVHHMSTFPS
GLAASRLAVETVPEEIRDSMNCRSIKDQAVGTRT
*SDDWMSLYCMYLVIKMPLCRKYASRGYTFLPF
LKNIFVEKIIKSPFWKLTAGFVP*QPLPM*GL*
KVSCDLTQKRNKHTQNSFMSDSSDALPNWLVDQE
FWGWGLRRNQV*NSF*LKKYSGIQLSAVSPS*C
IYCEYLLDS*VILLIN*AKCLCAIVFPLPCKIL
YSINK*KNHCFSQLFQNQGL*IL*ILFLCDVSYC
FIML*LVEILYIYFLLI*CLNF*KVLTSLSPTP
LPSHEVNS*ELSGVTGELIADHVVLQGGSPPSG
PGISSQVGFNSWALPPL**SVCLMPVRNSVWQAT
KFYSKKYPATFCLFQSN*LIMQANFADSRLYL*
ENKKTKVLSAGGKDFSIENLSLTTQRLEKK*NV
PLPEVLHCSCSGLGPGRTSEWVGQVAPA*GPPQA
TNPLWTTVSSWVFPHLLCNFLCFEVGLTCLQEL
INCTALPTPHPYGHCIWSACFFRSMPSF*YSIS
FRGGWGPTGLGVKM*KLMGALRRLHGGSMQVVLP
SLLI*PGACVCPLTYTWGGGNVSTDDAKSVGVY
SKQHCV*EASSSSQLSNLTTFIWEFQTIEALLC
FMSRFCDH*LLYQNSSGTHL*IALIWLYTDPSLT
CFLGPSVCSICIAVSLAYLCFALMNFDRVIATL
LVQYCCK*LQIFKQSFMLIL*K*NFQLV

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