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Sequence BCL2L11.nAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTAT
TGGAGACGAGTTTAACGCTTACTATGCAAGGAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAA
GCGTTTGAGACGGAGCTGTGGAGGCTGAATCCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACG
AATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCT
TGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACAC
CGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAA
TATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGA
AATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAAC
TGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATT
GCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATA
TACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGT
GATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTAT
CTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGC
AATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCAT
CAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCT
GATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCAC
CAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGT
GAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCA
AGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACT
TTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGT
GGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAAT
ACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTC
GAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTG
GATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACA
CACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCT
CCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGA
CTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATT
TTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTG
ACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTG
GGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAG
TATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATA
AGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCT
GTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCAT
GAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCA
GTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTC
CAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAA
ACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGG
TGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTT
GTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACA
GCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTT
GGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGAT
TTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCAT
TGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGAT
TCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGG
ACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATAC
TGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Single exon skipping
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRI
GDEFNAYYARRLEK*RKLSCSCHVFSPLKGSGE
AFETELWRLNP*RRR*ERHRYF*IITKQPKTTH
EWLSYDCYVTLSAWCGECIDRFFAEPRYHADILL
VQTNKTQHRGLLVPLLCSQRFSCGGGR*RFRRH
RAGWDYLSVHHHTAEFLMEVCCECKGGSILCFL
IYKPWFFGAGFCVRMVFTCSVFSPSPSIRFFKKE
METF*PICE*LLY*NFKNLRPILRGLCNPCSGN
*AS*LKKLP*FIFRDYRIFKQGDV*YTPSLPYY
CLSDLFKLFLIPKEFF*NGTD*KGRGSVASLH*Y
TSPICKYLRTFINSVASVAKFQTIFASFLITFC
DATPVWTQMHRFGPVYFHDKVKLSQNKS*YLPV
SCTVRAICY*LGSIWCWFSFHFDEHVIGKYSEEA
IAVITTDLSATPLCAAGFSGCRLSHGHRMHCQH
QVPEGHRVHYSRVQLQHPAHALMGIGTGLGQGF
*WPFAWPPAF*SNSQSTSFTPLNSL*NRPHPTST
STIEE*FWAEVCFFSFFQDSWILSGHL*PQPCS
EGALSLCLLLMSAVEGSHTLVSHFRGSRCPGRP
KKESG*GAVKVRREDNSVNSVTLKIFENSIVKQL
LKEITKFSNE*AVPPTSVLPDRRASMFTLFKLG
GKI*TFLSS*FKKYICIYCIFTFSFR*R*FQSK
YSYFKKFPFPKNLLGTLTYF*SCVGAHLVP*CVS
SPLVGSYKAHGYKQW*DCSRGPAGHTHTPKMYL
DLGTPSQDPCTHVPVS*LEHFTLFPQPCSPWEH
TLGAALGQAREALPCAAQGLCAPHEHISLWPGGL
QAGCGNSS*GN*RFYEL*EY*RPGCWHQNLKR*
LDVSVLYVSGYQDASVQKVCLPWVYVFTFFKKH
FCRKNN*IPFLETYCRFCALTTSPYVRFVKSVL*
LNTETQ*THTK*FHE*FFRCPSQLVS*SRILGV
GVAEKSSLKFLLIKKI*WNTIVCRFPFLMYIL*
VFIRFVGHITYQLSQMSVCNCVSFTL*NFVQHK*
VKKSLFFSTFSKSRIVNIVDSFSV*CVLLFHNA
VTCRNIVYLFSAYLMS*FLKSINIPVSHSPAVP
*S*LLRVVGGDWRAHCRPRGPPGWLSTFGSWYFQ
SSGFQFLGFAALMMKCVFDASEKLSLAGYKILL
QEIPSNLLFVPKQLAYHASKFC*LQALSLGKQK
NQSIISRWERFFY*KFIPDNSAFRKEIKCATSRG
AALQLFRARARQDK*MGGTGGSCLRTTSGH*PL
VDNCE*LGFPPPAVQLPVL*GWTNLSSGAN*LY
SPPHAPPIRSLHLVSLLLQVDALLLILHLLQGRL
GPHWTGCQDVKAYGSFKETSWWFHAGGSAIPAD
LAWCLCVSTHVHVGWGKRVYR*R*ISWGLL*TA
LCVRSILKLPVK*LDYFYLGISDYRSSLMFYVQI
L*PLVTVSELIRYPLINSTDLAVY*SITNLFSR
TQRM*HLYCSFPGLLVFCTDEF*QGNCHFTCAI
LL*ITADF*TIFYVNFIKIKLSTSF
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKLP*GRLNLQICAQRYGSPKSCGV
LETSLTLTMQGG*RNRGSCRVVVMYSVHLRAVGK
RLRRSCGG*ILEGGGERGTGIFE*LPSSRRPPT
NGYLTTVTLHCPPGVENALTGSLRSRDTMQTFC
LFKPTRPSTAVSWCHYYAASGSLVEGAGDVSEDT
ELDGTTFLFITTQQNF*WKFVVNVKEGAFFAF*
YTNHGFLEQDFV*EWCLHAVCFPPHLQ*GFSKR
KWKLFNQFVNNFCIKILRTYGLFSEDYVTPAVET
EPANLKSCLSLFLEITEFLNRETCDILPPFPTI
ASLTFLNYF*YQKSSFEMELIKRAEGLLPACID
IPVPFVNIYVPL*IQLHLWQNFRLFLRLSSSLFV
MQLQSGLRCIDLVQCIFMIK*N*VRTRVNICLY
LAQFERSVINWEAFGVGFHSISTSMLLGSILKR
Q*Q**QQT*VLRPFVLLAFLVAGFPMVTGCTVSI
RSQRATVSITAESSCSIQLTPSWELAQAWGRAS
DGHLLGLLHFSPTHSPLASLL*IHFETGLIPLP
PAP*KNNSGQKSVFFHFSRTVGYCQATCDPSHVV
RVLFLCACSL*VQWKEATHWSVISEAADAQGDP
RKSQVREQ*K*GGKTIL*TL*LLKFLKTPSLNN
F*KK*LNFQMSKQCHQLVFCPIEEPACSRYLN*V
EKSKHFYLHNLKNIYVYIAYSLFPLGRDDFNPN
TLTLKNFLSPRISLGL*LIFKAVLELILFPDVS
RAHW*GHTKPTVTSSGRIAAVGLLDTHIHQRCIW
IWAPPPRIPVLTCQSPD*STLLCFLSPAAPGST
HWVQPWARHGRPCPVLPRGCVHHMSTFPSGLAA
SRLAVETVPEEIRDSMNCRSIKDQAVGTRT*SDD
WMSLYCMYLVIKMPLCRKYASRGYTFLPFLKNI
FVEKIIKSPFWKLTAGFVP*QPLPM*GL*KVSC
DLTQKRNKHTQNSFMSDSSDALPNWLVDQEFWGW
GLRRNQV*NSF*LKKYSGIQLSAVSPS*CIYCE
YLLDS*VILLIN*AKCLCAIVFPLPCKILYSIN
K*KNHCFSQLFQNQGL*IL*ILFLCDVSYCFIML
*LVEILYIYFLLI*CLNF*KVLTSLSPTPLPSH
EVNS*ELSGVTGELIADHVVLQGGSPPSGPGIS
SQVGFNSWALPPL**SVCLMPVRNSVWQATKFYS
KKYPATFCLFQSN*LIMQANFADSRLYL*ENKK
TKVLSAGGKDFSIENLSLTTQRLEKK*NVPLPE
VLHCSCSGLGPGRTSEWVGQVAPA*GPPQATNPL
WTTVSSWVFPHLLCNFLCFEVGLTCLQELINCT
ALPTPHPYGHCIWSACFFRSMPSF*YSISFRGG
WGPTGLGVKM*KLMGALRRLHGGSMQVVLPSLLI
*PGACVCPLTYTWGGGNVSTDDAKSVGVYSKQH
CV*EASSSSQLSNLTTFIWEFQTIEALLCFMSR
FCDH*LLYQNSSGTHL*IALIWLYTDPSLTCFLG
PSVCSICIAVSLAYLCFALMNFDRVIATLLVQY
CCK*LQIFKQSFMLIL*K*NFQLV
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATSFHEAG*TCRYAPRDMDRPRVAAY
WRRV*RLLCKEVREIEEVVV*LSCIQST*GQWG
SV*DGAVEAESLKEEVREAQVFLNNYQAAEDHPR
MVILRLLRYIVRLVWRMH*QVLCGAEIPCRHFA
CSNQQDPAPRSPGAIIMQPAVLLWRGQVTFQKT
PSWMGLPFCSSPHSRISNGSLL*M*RREHSLLFN
IQTMVFWSRILCKNGVYMQCVFPLTFNKVFQKG
NGNFLTNL*ITFVLKF*EPTAYSQRIM*PLQWK
LSQLT*KAALVYF*RLQNF*TGRRVIYSLPSLLL
PL*PF*IIFNTKRVLLKWN*LKGQRVCCQPALI
YQSHL*IFTYLYKFSCICGKISDYFCVFPHHFL
*CNSSLDSDA*IWSSVFS**SEIESEQELISACI
LHSSSDLLLTGKHLVLVFIPFRRACYWEVF*RG
NSSNNNRLKCYAPLCCWLFWLQAFPWSQDALSA
SGPRGPPCPLQQSPAAASSSRPHGNWHRPGAGLL
MAICLASCILVQLTVH*LHSFKFTLKQASSHFH
QHHRRIILGRSLFFFIFPGQLDIVRPLVTPAM*
*GCSFSVPAPYECSGRKPHTGQSFQRQQMPRETQ
ERVRLGSSESEEGRQFCELCNS*NF*KLHR*TT
FKRNN*IFK*VSSATN*CFAR*KSQHVHVI*IR
WKNLNIFIFII*KIYMYILHIHFFL*VEMISIQI
LLL*KISFPQESPWDFDLFLKLCWSSSCSLMCL
EPIGRVIQSPRLQAVVGLQPWACWTHTYTKDVF
GSGHPLPGSLYSRASLLTRALYSVSSALQPLGAH
TGCSPGPGTGGPALCCPGAVCTT*AHFPLAWRP
PGWLWKQFLRKLEIL*IVGVLKTRLLAPELKAM
TGCLCTVCIWLSRCLCAESMPPVGIRFYLF*KTF
L*KK*LNPLFGNLLQVLCLDNLSLCEVCKKCPV
T*HRNAINTHKIVS*VILQMPFPTG*LIKNFGG
GGCGEIKFKIPSD*KNIVEYNCLPFPLLNVYIVS
IY*IRRSYYLSTEPNVCVQLCFLYLVKFCTA*I
SKKITVFLNFFKIKDCKYCRFFFCVMCPTVS*C
CNL*KYCIFIFCLFNVLISEKY*HPCLPLPCRPM
KLTPESCRG*LESSLQTTWSSRVALHLRVLVFP
VKWVSILGLCRPYDEVCV*CQ*ETQSGRLQNST
PRNTQQPSVCSKATSLSCKQILLTPGFIFRKTKK
PKYYQQVGKIFLLKIYP*QLSV*KRNKMCHFQR
CCIAVVQG*GQAGQVNGWDRWLLPKDHLRPLTP
CGQL*VAGFSPTCCATSCALRLD*LVFRS*LTVQ
PSPRPTHTVTAFGQPASSGRCPPSDTPSPSGEV
GAPLDWVSRCESLWEL*GDFMVVPCRWFCHPC*
FSLVPVCVHSRTRGVGETCLQMTLNQLGSTLNSI
VCKKHPQAPS*VT*LLLFGNFRL*KLSYVLCPD
SVTTSYCIRTHQVPTYK*H*SGCILIHH*PVF*
DPAYVAFVLQFPWLTCVLH**ILTG*LPLYLCNT
AVNNCRFLNNLLC*FYKNKTFN*F
Sequence BCL2L11.mAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTAT
TGGAGACGAGTTTAACGCTTACTATGCAAGGAGGCTGGCAAAACTCCTGGCATCCTCCACCTGACATAAACCAGTTCACAGAACATTCCAGCCTAGATCT
GAAATGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGACGGAGCTGTGGAGGCTGA
ATCCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTAC
ATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGC
GGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTC
ATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGG
ATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAA
TAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTT
AGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTT
AATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGT
ACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGC
ATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTA
ACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGT
GCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATT
ACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATT
TTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCA
GAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCC
TTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAA
AGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAAT
GAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCAT
AATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCC
CAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCC
CACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCT
GTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACG
GGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGA
GGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTG
GTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTT
TTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACAC
ACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAAT
TCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTAC
TTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACT
TTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTAT
TTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGG
TGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTT
GCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTG
TTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAG
ATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGG
GCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTC
CCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTC
ACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGAT
GTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTC
ACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCC
AGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAA
CTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCA
GTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAAC
AATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Single exon skipping
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRI
GDEFNAYYARRLAKLLASST*HKPVHRTFQPRS
EMLEK*RKLSCSCHVFSPLKGSGEAFETELWRL
NP*RRR*ERHRYF*IITKQPKTTHEWLSYDCYVT
LSAWCGECIDRFFAEPRYHADILLVQTNKTQHR
GLLVPLLCSQRFSCGGGR*RFRRHRAGWDYLSV
HHHTAEFLMEVCCECKGGSILCFLIYKPWFFGAG
FCVRMVFTCSVFSPSPSIRFFKKEMETF*PICE
*LLY*NFKNLRPILRGLCNPCSGN*AS*LKKLP
*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKLFL
IPKEFF*NGTD*KGRGSVASLH*YTSPICKYLR
TFINSVASVAKFQTIFASFLITFCDATPVWTQM
HRFGPVYFHDKVKLSQNKS*YLPVSCTVRAICY*
LGSIWCWFSFHFDEHVIGKYSEEAIAVITTDLS
ATPLCAAGFSGCRLSHGHRMHCQHQVPEGHRVH
YSRVQLQHPAHALMGIGTGLGQGF*WPFAWPPAF
*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*FWA
EVCFFSFFQDSWILSGHL*PQPCSEGALSLCLL
LMSAVEGSHTLVSHFRGSRCPGRPKKESG*GAVK
VRREDNSVNSVTLKIFENSIVKQLLKEITKFSN
E*AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS
*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFPFP
KNLLGTLTYF*SCVGAHLVP*CVSSPLVGSYKA
HGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQDP
CTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQAR
EALPCAAQGLCAPHEHISLWPGGLQAGCGNSS*
GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLYVS
GYQDASVQKVCLPWVYVFTFFKKHFCRKNN*IPF
LETYCRFCALTTSPYVRFVKSVL*LNTETQ*TH
TK*FHE*FFRCPSQLVS*SRILGVGVAEKSSLK
FLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGHIT
YQLSQMSVCNCVSFTL*NFVQHK*VKKSLFFST
FSKSRIVNIVDSFSV*CVLLFHNAVTCRNIVYL
FSAYLMS*FLKSINIPVSHSPAVP*S*LLRVVGG
DWRAHCRPRGPPGWLSTFGSWYFQSSGFQFLGF
AALMMKCVFDASEKLSLAGYKILLQEIPSNLLF
VPKQLAYHASKFC*LQALSLGKQKNQSIISRWER
FFY*KFIPDNSAFRKEIKCATSRGAALQLFRAR
ARQDK*MGGTGGSCLRTTSGH*PLVDNCE*LGF
PPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPIRS
LHLVSLLLQVDALLLILHLLQGRLGPHWTGCQD
VKAYGSFKETSWWFHAGGSAIPADLAWCLCVST
HVHVGWGKRVYR*R*ISWGLL*TALCVRSILKLP
VK*LDYFYLGISDYRSSLMFYVQIL*PLVTVSE
LIRYPLINSTDLAVY*SITNLFSRTQRM*HLYC
SFPGLLVFCTDEF*QGNCHFTCAILL*ITADF*T
IFYVNFIKIKLSTSF
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKLP*GRLNLQICAQRYGSPKSCGV
LETSLTLTMQGGWQNSWHPPPDINQFTEHSSLDL
KC*RNRGSCRVVVMYSVHLRAVGKRLRRSCGG*
ILEGGGERGTGIFE*LPSSRRPPTNGYLTTVTL
HCPPGVENALTGSLRSRDTMQTFCLFKPTRPSTA
VSWCHYYAASGSLVEGAGDVSEDTELDGTTFLF
ITTQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQ
DFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVN
NFCIKILRTYGLFSEDYVTPAVETEPANLKSCL
SLFLEITEFLNRETCDILPPFPTIASLTFLNYF
*YQKSSFEMELIKRAEGLLPACIDIPVPFVNIYV
PL*IQLHLWQNFRLFLRLSSSLFVMQLQSGLRC
IDLVQCIFMIK*N*VRTRVNICLYLAQFERSVI
NWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT*V
LRPFVLLAFLVAGFPMVTGCTVSIRSQRATVSI
TAESSCSIQLTPSWELAQAWGRASDGHLLGLLH
FSPTHSPLASLL*IHFETGLIPLPPAP*KNNSGQ
KSVFFHFSRTVGYCQATCDPSHVVRVLFLCACS
L*VQWKEATHWSVISEAADAQGDPRKSQVREQ*
K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNFQM
SKQCHQLVFCPIEEPACSRYLN*VEKSKHFYLH
NLKNIYVYIAYSLFPLGRDDFNPNTLTLKNFLS
PRISLGL*LIFKAVLELILFPDVSRAHW*GHTKP
TVTSSGRIAAVGLLDTHIHQRCIWIWAPPPRIP
VLTCQSPD*STLLCFLSPAAPGSTHWVQPWARH
GRPCPVLPRGCVHHMSTFPSGLAASRLAVETVPE
EIRDSMNCRSIKDQAVGTRT*SDDWMSLYCMYL
VIKMPLCRKYASRGYTFLPFLKNIFVEKIIKSP
FWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNKHT
QNSFMSDSSDALPNWLVDQEFWGWGLRRNQV*N
SF*LKKYSGIQLSAVSPS*CIYCEYLLDS*VIL
LIN*AKCLCAIVFPLPCKILYSINK*KNHCFSQL
FQNQGL*IL*ILFLCDVSYCFIML*LVEILYIY
FLLI*CLNF*KVLTSLSPTPLPSHEVNS*ELSG
VTGELIADHVVLQGGSPPSGPGISSQVGFNSWAL
PPL**SVCLMPVRNSVWQATKFYSKKYPATFCL
FQSN*LIMQANFADSRLYL*ENKKTKVLSAGGK
DFSIENLSLTTQRLEKK*NVPLPEVLHCSCSGLG
PGRTSEWVGQVAPA*GPPQATNPLWTTVSSWVF
PHLLCNFLCFEVGLTCLQELINCTALPTPHPYG
HCIWSACFFRSMPSF*YSISFRGGWGPTGLGVKM
*KLMGALRRLHGGSMQVVLPSLLI*PGACVCPL
TYTWGGGNVSTDDAKSVGVYSKQHCV*EASSSS
QLSNLTTFIWEFQTIEALLCFMSRFCDH*LLYQN
SSGTHL*IALIWLYTDPSLTCFLGPSVCSICIA
VSLAYLCFALMNFDRVIATLLVQYCCK*LQIFK
QSFMLIL*K*NFQLV
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATSFHEAG*TCRYAPRDMDRPRVAAY
WRRV*RLLCKEAGKTPGILHLT*TSSQNIPA*I
*NVREIEEVVV*LSCIQST*GQWGSV*DGAVEAE
SLKEEVREAQVFLNNYQAAEDHPRMVILRLLRY
IVRLVWRMH*QVLCGAEIPCRHFACSNQQDPAP
RSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPFCS
SPHSRISNGSLL*M*RREHSLLFNIQTMVFWSR
ILCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*
ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KAAL
VYF*RLQNF*TGRRVIYSLPSLLLPL*PF*IIF
NTKRVLLKWN*LKGQRVCCQPALIYQSHL*IFT
YLYKFSCICGKISDYFCVFPHHFL*CNSSLDSDA
*IWSSVFS**SEIESEQELISACILHSSSDLLL
TGKHLVLVFIPFRRACYWEVF*RGNSSNNNRLK
CYAPLCCWLFWLQAFPWSQDALSASGPRGPPCPL
QQSPAAASSSRPHGNWHRPGAGLLMAICLASCI
LVQLTVH*LHSFKFTLKQASSHFHQHHRRIILG
RSLFFFIFPGQLDIVRPLVTPAM**GCSFSVPAP
YECSGRKPHTGQSFQRQQMPRETQERVRLGSSE
SEEGRQFCELCNS*NF*KLHR*TTFKRNN*IFK
*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFIFI
I*KIYMYILHIHFFL*VEMISIQILLL*KISFP
QESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQS
PRLQAVVGLQPWACWTHTYTKDVFGSGHPLPGSL
YSRASLLTRALYSVSSALQPLGAHTGCSPGPGT
GGPALCCPGAVCTT*AHFPLAWRPPGWLWKQFL
RKLEIL*IVGVLKTRLLAPELKAMTGCLCTVCIW
LSRCLCAESMPPVGIRFYLF*KTFL*KK*LNPL
FGNLLQVLCLDNLSLCEVCKKCPVT*HRNAINT
HKIVS*VILQMPFPTG*LIKNFGGGGCGEIKFKI
PSD*KNIVEYNCLPFPLLNVYIVSIY*IRRSYY
LSTEPNVCVQLCFLYLVKFCTA*ISKKITVFLN
FFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCIFI
FCLFNVLISEKY*HPCLPLPCRPMKLTPESCRG
*LESSLQTTWSSRVALHLRVLVFPVKWVSILGL
CRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVC
SKATSLSCKQILLTPGFIFRKTKKPKYYQQVGK
IFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*
GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAGFS
PTCCATSCALRLD*LVFRS*LTVQPSPRPTHTV
TAFGQPASSGRCPPSDTPSPSGEVGAPLDWVSR
CESLWEL*GDFMVVPCRWFCHPC*FSLVPVCVHS
RTRGVGETCLQMTLNQLGSTLNSIVCKKHPQAP
S*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIR
THQVPTYK*H*SGCILIHH*PVF*DPAYVAFVLQ
FPWLTCVLH**ILTG*LPLYLCNTAVNNCRFLN
NLLC*FYKNKTFN*F
Sequence BCL2L11.kAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTAT
TGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGT
TACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCAC
CGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTG
TTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGC
AGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGT
GAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGC
CTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATT
TTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTA
CGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGA
TGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTA
TTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTA
AGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCC
ATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGC
ATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGG
GCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGC
TCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGT
GAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCA
AATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTT
CATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTT
CCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAA
GCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATC
CCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGC
ACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCC
TGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTAT
CTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCC
CTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACA
CACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAA
AATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATAT
TACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCA
ACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATT
TATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGG
GGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGC
TTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGT
TTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGA
AAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCT
AGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTT
TTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACG
GTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAA
GATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCA
CTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCT
CCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCA
GAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATT
GCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTA
AACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Single exon skipping
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRI
GDEFNAYYARRVFLNNYQAAEDHPRMVILRLLR
YIVRLVWRMH*QVLCGAEIPCRHFACSNQQDPA
PRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPFC
SSPHSRISNGSLL*M*RREHSLLFNIQTMVFWS
RILCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL
*ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KAA
LVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*II
FNTKRVLLKWN*LKGQRVCCQPALIYQSHL*IF
TYLYKFSCICGKISDYFCVFPHHFL*CNSSLDSD
A*IWSSVFS**SEIESEQELISACILHSSSDLL
LTGKHLVLVFIPFRRACYWEVF*RGNSSNNNRL
KCYAPLCCWLFWLQAFPWSQDALSASGPRGPPCP
LQQSPAAASSSRPHGNWHRPGAGLLMAICLASC
ILVQLTVH*LHSFKFTLKQASSHFHQHHRRIIL
GRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVPA
PYECSGRKPHTGQSFQRQQMPRETQERVRLGSS
ESEEGRQFCELCNS*NF*KLHR*TTFKRNN*IF
K*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFIF
II*KIYMYILHIHFFL*VEMISIQILLL*KISF
PQESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQ
SPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPGS
LYSRASLLTRALYSVSSALQPLGAHTGCSPGPG
TGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQF
LRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVCI
WLSRCLCAESMPPVGIRFYLF*KTFL*KK*LNP
LFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAIN
THKIVS*VILQMPFPTG*LIKNFGGGGCGEIKFK
IPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRSY
YLSTEPNVCVQLCFLYLVKFCTA*ISKKITVFL
NFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCIF
IFCLFNVLISEKY*HPCLPLPCRPMKLTPESCR
G*LESSLQTTWSSRVALHLRVLVFPVKWVSILG
LCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPSV
CSKATSLSCKQILLTPGFIFRKTKKPKYYQQVG
KIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG
*GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAGF
SPTCCATSCALRLD*LVFRS*LTVQPSPRPTHT
VTAFGQPASSGRCPPSDTPSPSGEVGAPLDWVS
RCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCVH
SRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQA
PS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCI
RTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFVL
QFPWLTCVLH**ILTG*LPLYLCNTAVNNCRFL
NNLLC*FYKNKTFN*F
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKLP*GRLNLQICAQRYGSPKSCGV
LETSLTLTMQGGYF*IITKQPKTTHEWLSYDCYV
TLSAWCGECIDRFFAEPRYHADILLVQTNKTQH
RGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYLS
VHHHTAEFLMEVCCECKGGSILCFLIYKPWFFGA
GFCVRMVFTCSVFSPSPSIRFFKKEMETF*PIC
E*LLY*NFKNLRPILRGLCNPCSGN*AS*LKKL
P*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKLF
LIPKEFF*NGTD*KGRGSVASLH*YTSPICKYL
RTFINSVASVAKFQTIFASFLITFCDATPVWTQ
MHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAICY
*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTDL
SATPLCAAGFSGCRLSHGHRMHCQHQVPEGHRV
HYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPPA
F*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*FW
AEVCFFSFFQDSWILSGHL*PQPCSEGALSLCL
LLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GAV
KVRREDNSVNSVTLKIFENSIVKQLLKEITKFS
NE*AVPPTSVLPDRRASMFTLFKLGGKI*TFLS
S*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFPF
PKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSYK
AHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQD
PCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQA
REALPCAAQGLCAPHEHISLWPGGLQAGCGNSS
*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLYV
SGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*IP
FLETYCRFCALTTSPYVRFVKSVL*LNTETQ*T
HTK*FHE*FFRCPSQLVS*SRILGVGVAEKSSL
KFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGHI
TYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFFS
TFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIVY
LFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVVG
GDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFLG
FAALMMKCVFDASEKLSLAGYKILLQEIPSNLL
FVPKQLAYHASKFC*LQALSLGKQKNQSIISRWE
RFFY*KFIPDNSAFRKEIKCATSRGAALQLFRA
RARQDK*MGGTGGSCLRTTSGH*PLVDNCE*LG
FPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPIR
SLHLVSLLLQVDALLLILHLLQGRLGPHWTGCQ
DVKAYGSFKETSWWFHAGGSAIPADLAWCLCVS
THVHVGWGKRVYR*R*ISWGLL*TALCVRSILKL
PVK*LDYFYLGISDYRSSLMFYVQIL*PLVTVS
ELIRYPLINSTDLAVY*SITNLFSRTQRM*HLY
CSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF*
TIFYVNFIKIKLSTSF
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATSFHEAG*TCRYAPRDMDRPRVAAY
WRRV*RLLCKEGIFE*LPSSRRPPTNGYLTTVT
LHCPPGVENALTGSLRSRDTMQTFCLFKPTRPST
AVSWCHYYAASGSLVEGAGDVSEDTELDGTTFL
FITTQQNF*WKFVVNVKEGAFFAF*YTNHGFLE
QDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFV
NNFCIKILRTYGLFSEDYVTPAVETEPANLKSC
LSLFLEITEFLNRETCDILPPFPTIASLTFLNY
F*YQKSSFEMELIKRAEGLLPACIDIPVPFVNIY
VPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGLR
CIDLVQCIFMIK*N*VRTRVNICLYLAQFERSV
INWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT*
VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATVS
ITAESSCSIQLTPSWELAQAWGRASDGHLLGLL
HFSPTHSPLASLL*IHFETGLIPLPPAP*KNNSG
QKSVFFHFSRTVGYCQATCDPSHVVRVLFLCAC
SL*VQWKEATHWSVISEAADAQGDPRKSQVREQ
*K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNFQ
MSKQCHQLVFCPIEEPACSRYLN*VEKSKHFYL
HNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNFL
SPRISLGL*LIFKAVLELILFPDVSRAHW*GHTK
PTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPRI
PVLTCQSPD*STLLCFLSPAAPGSTHWVQPWAR
HGRPCPVLPRGCVHHMSTFPSGLAASRLAVETVP
EEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCMY
LVIKMPLCRKYASRGYTFLPFLKNIFVEKIIKS
PFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNKH
TQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV*
NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*VI
LLIN*AKCLCAIVFPLPCKILYSINK*KNHCFSQ
LFQNQGL*IL*ILFLCDVSYCFIML*LVEILYI
YFLLI*CLNF*KVLTSLSPTPLPSHEVNS*ELS
GVTGELIADHVVLQGGSPPSGPGISSQVGFNSWA
LPPL**SVCLMPVRNSVWQATKFYSKKYPATFC
LFQSN*LIMQANFADSRLYL*ENKKTKVLSAGG
KDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSGL
GPGRTSEWVGQVAPA*GPPQATNPLWTTVSSWV
FPHLLCNFLCFEVGLTCLQELINCTALPTPHPY
GHCIWSACFFRSMPSF*YSISFRGGWGPTGLGVK
M*KLMGALRRLHGGSMQVVLPSLLI*PGACVCP
LTYTWGGGNVSTDDAKSVGVYSKQHCV*EASSS
SQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLYQ
NSSGTHL*IALIWLYTDPSLTCFLGPSVCSICI
AVSLAYLCFALMNFDRVIATLLVQYCCK*LQIF
KQSFMLIL*K*NFQLV
Sequence BCL2L11.jAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAA
CCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAG
TTTAACGCTTACTATGCAAGGAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGA
CGGAGCTGTGGAGGCTGAATCCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATC
TTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACC
AACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGAT
GGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACC
ATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACT
TTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCT
AACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGA
CCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCC
ATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTC
CAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGT
TCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTA
ATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAG
AGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATT
TGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATA
GAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTC
TTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTC
AGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAA
ATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCT
AAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTT
TAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTG
GTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCA
CCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGC
AGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGC
TGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCT
CTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAA
AAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACA
GAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGG
AGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAG
ATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAA
TCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTA
GAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACT
CCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGG
TTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATAC
CCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTAT
TATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTG
CAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACT
GTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCA
CGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCAC
TGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGT
GCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAG
AAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCA
CTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTA
TGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAAT
AACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Single exon skipping
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFN
HYLSAMASMRQAEPADMRPEIWIAQELRRIGDE
FNAYYARRLEK*RKLSCSCHVFSPLKGSGEAFE
TELWRLNP*RRR*ERHRYF*IITKQPKTTHEWLS
YDCYVTLSAWCGECIDRFFAEPRYHADILLVQT
NKTQHRGLLVPLLCSQRFSCGGGR*RFRRHRAG
WDYLSVHHHTAEFLMEVCCECKGGSILCFLIYKP
WFFGAGFCVRMVFTCSVFSPSPSIRFFKKEMET
F*PICE*LLY*NFKNLRPILRGLCNPCSGN*AS
*LKKLP*FIFRDYRIFKQGDV*YTPSLPYYCLSD
LFKLFLIPKEFF*NGTD*KGRGSVASLH*YTSP
ICKYLRTFINSVASVAKFQTIFASFLITFCDAT
PVWTQMHRFGPVYFHDKVKLSQNKS*YLPVSCTV
RAICY*LGSIWCWFSFHFDEHVIGKYSEEAIAV
ITTDLSATPLCAAGFSGCRLSHGHRMHCQHQVP
EGHRVHYSRVQLQHPAHALMGIGTGLGQGF*WPF
AWPPAF*SNSQSTSFTPLNSL*NRPHPTSTSTI
EE*FWAEVCFFSFFQDSWILSGHL*PQPCSEGA
LSLCLLLMSAVEGSHTLVSHFRGSRCPGRPKKES
G*GAVKVRREDNSVNSVTLKIFENSIVKQLLKE
ITKFSNE*AVPPTSVLPDRRASMFTLFKLGGKI
*TFLSS*FKKYICIYCIFTFSFR*R*FQSKYSYF
KKFPFPKNLLGTLTYF*SCVGAHLVP*CVSSPL
VGSYKAHGYKQW*DCSRGPAGHTHTPKMYLDLG
TPSQDPCTHVPVS*LEHFTLFPQPCSPWEHTLGA
ALGQAREALPCAAQGLCAPHEHISLWPGGLQAG
CGNSS*GN*RFYEL*EY*RPGCWHQNLKR*LDV
SVLYVSGYQDASVQKVCLPWVYVFTFFKKHFCRK
NN*IPFLETYCRFCALTTSPYVRFVKSVL*LNT
ETQ*THTK*FHE*FFRCPSQLVS*SRILGVGVA
EKSSLKFLLIKKI*WNTIVCRFPFLMYIL*VFIR
FVGHITYQLSQMSVCNCVSFTL*NFVQHK*VKK
SLFFSTFSKSRIVNIVDSFSV*CVLLFHNAVTC
RNIVYLFSAYLMS*FLKSINIPVSHSPAVP*S*L
LRVVGGDWRAHCRPRGPPGWLSTFGSWYFQSSG
FQFLGFAALMMKCVFDASEKLSLAGYKILLQEI
PSNLLFVPKQLAYHASKFC*LQALSLGKQKNQSI
ISRWERFFY*KFIPDNSAFRKEIKCATSRGAAL
QLFRARARQDK*MGGTGGSCLRTTSGH*PLVDN
CE*LGFPPPAVQLPVL*GWTNLSSGAN*LYSPPH
APPIRSLHLVSLLLQVDALLLILHLLQGRLGPH
WTGCQDVKAYGSFKETSWWFHAGGSAIPADLAW
CLCVSTHVHVGWGKRVYR*R*ISWGLL*TALCVR
SILKLPVK*LDYFYLGISDYRSSLMFYVQIL*P
LVTVSELIRYPLINSTDLAVY*SITNLFSRTQR
M*HLYCSFPGLLVFCTDEF*QGNCHFTCAILL*I
TADF*TIFYVNFIKIKLSTSF
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKTGAQHP*VVTNQHKPQVLLARPS
TTISVQWLP*GRLNLQICAQRYGSPKSCGVLETS
LTLTMQGG*RNRGSCRVVVMYSVHLRAVGKRLR
RSCGG*ILEGGGERGTGIFE*LPSSRRPPTNGY
LTTVTLHCPPGVENALTGSLRSRDTMQTFCLFKP
TRPSTAVSWCHYYAASGSLVEGAGDVSEDTELD
GTTFLFITTQQNF*WKFVVNVKEGAFFAF*YTN
HGFLEQDFV*EWCLHAVCFPPHLQ*GFSKRKWKL
FNQFVNNFCIKILRTYGLFSEDYVTPAVETEPA
NLKSCLSLFLEITEFLNRETCDILPPFPTIASL
TFLNYF*YQKSSFEMELIKRAEGLLPACIDIPVP
FVNIYVPL*IQLHLWQNFRLFLRLSSSLFVMQL
QSGLRCIDLVQCIFMIK*N*VRTRVNICLYLAQ
FERSVINWEAFGVGFHSISTSMLLGSILKRQ*Q*
*QQT*VLRPFVLLAFLVAGFPMVTGCTVSIRSQ
RATVSITAESSCSIQLTPSWELAQAWGRASDGH
LLGLLHFSPTHSPLASLL*IHFETGLIPLPPAP*
KNNSGQKSVFFHFSRTVGYCQATCDPSHVVRVL
FLCACSL*VQWKEATHWSVISEAADAQGDPRKS
QVREQ*K*GGKTIL*TL*LLKFLKTPSLNNF*KK
*LNFQMSKQCHQLVFCPIEEPACSRYLN*VEKS
KHFYLHNLKNIYVYIAYSLFPLGRDDFNPNTLT
LKNFLSPRISLGL*LIFKAVLELILFPDVSRAHW
*GHTKPTVTSSGRIAAVGLLDTHIHQRCIWIWA
PPPRIPVLTCQSPD*STLLCFLSPAAPGSTHWV
QPWARHGRPCPVLPRGCVHHMSTFPSGLAASRLA
VETVPEEIRDSMNCRSIKDQAVGTRT*SDDWMS
LYCMYLVIKMPLCRKYASRGYTFLPFLKNIFVE
KIIKSPFWKLTAGFVP*QPLPM*GL*KVSCDLTQ
KRNKHTQNSFMSDSSDALPNWLVDQEFWGWGLR
RNQV*NSF*LKKYSGIQLSAVSPS*CIYCEYLL
DS*VILLIN*AKCLCAIVFPLPCKILYSINK*KN
HCFSQLFQNQGL*IL*ILFLCDVSYCFIML*LV
EILYIYFLLI*CLNF*KVLTSLSPTPLPSHEVN
S*ELSGVTGELIADHVVLQGGSPPSGPGISSQVG
FNSWALPPL**SVCLMPVRNSVWQATKFYSKKY
PATFCLFQSN*LIMQANFADSRLYL*ENKKTKV
LSAGGKDFSIENLSLTTQRLEKK*NVPLPEVLHC
SCSGLGPGRTSEWVGQVAPA*GPPQATNPLWTT
VSSWVFPHLLCNFLCFEVGLTCLQELINCTALP
TPHPYGHCIWSACFFRSMPSF*YSISFRGGWGPT
GLGVKM*KLMGALRRLHGGSMQVVLPSLLI*PG
ACVCPLTYTWGGGNVSTDDAKSVGVYSKQHCV*
EASSSSQLSNLTTFIWEFQTIEALLCFMSRFCDH
*LLYQNSSGTHL*IALIWLYTDPSLTCFLGPSV
CSICIAVSLAYLCFALMNFDRVIATLLVQYCCK
*LQIFKQSFMLIL*K*NFQLV
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATRQEPSTHEL*QINTNPKSSLPGLQ
PLSQCNGFHEAG*TCRYAPRDMDRPRVAAYWRR
V*RLLCKEVREIEEVVV*LSCIQST*GQWGSV*D
GAVEAESLKEEVREAQVFLNNYQAAEDHPRMVI
LRLLRYIVRLVWRMH*QVLCGAEIPCRHFACSN
QQDPAPRSPGAIIMQPAVLLWRGQVTFQKTPSWM
GLPFCSSPHSRISNGSLL*M*RREHSLLFNIQT
MVFWSRILCKNGVYMQCVFPLTFNKVFQKGNGN
FLTNL*ITFVLKF*EPTAYSQRIM*PLQWKLSQL
T*KAALVYF*RLQNF*TGRRVIYSLPSLLLPL*
PF*IIFNTKRVLLKWN*LKGQRVCCQPALIYQS
HL*IFTYLYKFSCICGKISDYFCVFPHHFL*CNS
SLDSDA*IWSSVFS**SEIESEQELISACILHS
SSDLLLTGKHLVLVFIPFRRACYWEVF*RGNSS
NNNRLKCYAPLCCWLFWLQAFPWSQDALSASGPR
GPPCPLQQSPAAASSSRPHGNWHRPGAGLLMAI
CLASCILVQLTVH*LHSFKFTLKQASSHFHQHH
RRIILGRSLFFFIFPGQLDIVRPLVTPAM**GCS
FSVPAPYECSGRKPHTGQSFQRQQMPRETQERV
RLGSSESEEGRQFCELCNS*NF*KLHR*TTFKR
NN*IFK*VSSATN*CFAR*KSQHVHVI*IRWKNL
NIFIFII*KIYMYILHIHFFL*VEMISIQILLL
*KISFPQESPWDFDLFLKLCWSSSCSLMCLEPI
GRVIQSPRLQAVVGLQPWACWTHTYTKDVFGSGH
PLPGSLYSRASLLTRALYSVSSALQPLGAHTGC
SPGPGTGGPALCCPGAVCTT*AHFPLAWRPPGW
LWKQFLRKLEIL*IVGVLKTRLLAPELKAMTGCL
CTVCIWLSRCLCAESMPPVGIRFYLF*KTFL*K
K*LNPLFGNLLQVLCLDNLSLCEVCKKCPVT*H
RNAINTHKIVS*VILQMPFPTG*LIKNFGGGGCG
EIKFKIPSD*KNIVEYNCLPFPLLNVYIVSIY*
IRRSYYLSTEPNVCVQLCFLYLVKFCTA*ISKK
ITVFLNFFKIKDCKYCRFFFCVMCPTVS*CCNL*
KYCIFIFCLFNVLISEKY*HPCLPLPCRPMKLT
PESCRG*LESSLQTTWSSRVALHLRVLVFPVKW
VSILGLCRPYDEVCV*CQ*ETQSGRLQNSTPRNT
QQPSVCSKATSLSCKQILLTPGFIFRKTKKPKY
YQQVGKIFLLKIYP*QLSV*KRNKMCHFQRCCI
AVVQG*GQAGQVNGWDRWLLPKDHLRPLTPCGQL
*VAGFSPTCCATSCALRLD*LVFRS*LTVQPSP
RPTHTVTAFGQPASSGRCPPSDTPSPSGEVGAP
LDWVSRCESLWEL*GDFMVVPCRWFCHPC*FSLV
PVCVHSRTRGVGETCLQMTLNQLGSTLNSIVCK
KHPQAPS*VT*LLLFGNFRL*KLSYVLCPDSVT
TSYCIRTHQVPTYK*H*SGCILIHH*PVF*DPAY
VAFVLQFPWLTCVLH**ILTG*LPLYLCNTAVN
NCRFLNNLLC*FYKNKTFN*F
Sequence BCL2L11.dAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAA
CCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAG
TTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCC
GCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCC
TGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCA
CACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGT
GTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTT
TGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTAT
TTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCA
AAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTA
TAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATT
TGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGA
AGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGC
CCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAG
AGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCC
AACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCT
GTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAG
TGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGG
AGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAG
CAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAA
AAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAAT
CTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTT
ACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCA
CGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCC
CTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATT
AGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCA
AGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAA
ACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAAT
AGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCT
GATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAA
CTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAA
AATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGC
TTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGG
AGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCC
TTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAA
GCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTC
TATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGC
AGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACC
TGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCAT
TTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAG
CTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACA
CGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAG
TAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCA
GGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCC
TGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTT
TATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Single exon skipping
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFN
HYLSAMASMRQAEPADMRPEIWIAQELRRIGDE
FNAYYARRVFLNNYQAAEDHPRMVILRLLRYIV
RLVWRMH*QVLCGAEIPCRHFACSNQQDPAPRSP
GAIIMQPAVLLWRGQVTFQKTPSWMGLPFCSSP
HSRISNGSLL*M*RREHSLLFNIQTMVFWSRIL
CKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*ITF
VLKF*EPTAYSQRIM*PLQWKLSQLT*KAALVY
F*RLQNF*TGRRVIYSLPSLLLPL*PF*IIFNT
KRVLLKWN*LKGQRVCCQPALIYQSHL*IFTYLY
KFSCICGKISDYFCVFPHHFL*CNSSLDSDA*I
WSSVFS**SEIESEQELISACILHSSSDLLLTG
KHLVLVFIPFRRACYWEVF*RGNSSNNNRLKCYA
PLCCWLFWLQAFPWSQDALSASGPRGPPCPLQQ
SPAAASSSRPHGNWHRPGAGLLMAICLASCILV
QLTVH*LHSFKFTLKQASSHFHQHHRRIILGRSL
FFFIFPGQLDIVRPLVTPAM**GCSFSVPAPYE
CSGRKPHTGQSFQRQQMPRETQERVRLGSSESE
EGRQFCELCNS*NF*KLHR*TTFKRNN*IFK*VS
SATN*CFAR*KSQHVHVI*IRWKNLNIFIFII*
KIYMYILHIHFFL*VEMISIQILLL*KISFPQE
SPWDFDLFLKLCWSSSCSLMCLEPIGRVIQSPRL
QAVVGLQPWACWTHTYTKDVFGSGHPLPGSLYS
RASLLTRALYSVSSALQPLGAHTGCSPGPGTGG
PALCCPGAVCTT*AHFPLAWRPPGWLWKQFLRKL
EIL*IVGVLKTRLLAPELKAMTGCLCTVCIWLS
RCLCAESMPPVGIRFYLF*KTFL*KK*LNPLFG
NLLQVLCLDNLSLCEVCKKCPVT*HRNAINTHKI
VS*VILQMPFPTG*LIKNFGGGGCGEIKFKIPS
D*KNIVEYNCLPFPLLNVYIVSIY*IRRSYYLS
TEPNVCVQLCFLYLVKFCTA*ISKKITVFLNFFK
IKDCKYCRFFFCVMCPTVS*CCNL*KYCIFIFC
LFNVLISEKY*HPCLPLPCRPMKLTPESCRG*L
ESSLQTTWSSRVALHLRVLVFPVKWVSILGLCRP
YDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVCSK
ATSLSCKQILLTPGFIFRKTKKPKYYQQVGKIF
LLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*GQA
GQVNGWDRWLLPKDHLRPLTPCGQL*VAGFSPT
CCATSCALRLD*LVFRS*LTVQPSPRPTHTVTA
FGQPASSGRCPPSDTPSPSGEVGAPLDWVSRCES
LWEL*GDFMVVPCRWFCHPC*FSLVPVCVHSRT
RGVGETCLQMTLNQLGSTLNSIVCKKHPQAPS*
VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIRTHQ
VPTYK*H*SGCILIHH*PVF*DPAYVAFVLQFP
WLTCVLH**ILTG*LPLYLCNTAVNNCRFLNNL
LC*FYKNKTFN*F
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKTGAQHP*VVTNQHKPQVLLARPS
TTISVQWLP*GRLNLQICAQRYGSPKSCGVLETS
LTLTMQGGYF*IITKQPKTTHEWLSYDCYVTLS
AWCGECIDRFFAEPRYHADILLVQTNKTQHRGL
LVPLLCSQRFSCGGGR*RFRRHRAGWDYLSVHHH
TAEFLMEVCCECKGGSILCFLIYKPWFFGAGFC
VRMVFTCSVFSPSPSIRFFKKEMETF*PICE*L
LY*NFKNLRPILRGLCNPCSGN*AS*LKKLP*FI
FRDYRIFKQGDV*YTPSLPYYCLSDLFKLFLIP
KEFF*NGTD*KGRGSVASLH*YTSPICKYLRTF
INSVASVAKFQTIFASFLITFCDATPVWTQMHRF
GPVYFHDKVKLSQNKS*YLPVSCTVRAICY*LG
SIWCWFSFHFDEHVIGKYSEEAIAVITTDLSAT
PLCAAGFSGCRLSHGHRMHCQHQVPEGHRVHYSR
VQLQHPAHALMGIGTGLGQGF*WPFAWPPAF*S
NSQSTSFTPLNSL*NRPHPTSTSTIEE*FWAEV
CFFSFFQDSWILSGHL*PQPCSEGALSLCLLLMS
AVEGSHTLVSHFRGSRCPGRPKKESG*GAVKVR
REDNSVNSVTLKIFENSIVKQLLKEITKFSNE*
AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS*FK
KYICIYCIFTFSFR*R*FQSKYSYFKKFPFPKN
LLGTLTYF*SCVGAHLVP*CVSSPLVGSYKAHG
YKQW*DCSRGPAGHTHTPKMYLDLGTPSQDPCTH
VPVS*LEHFTLFPQPCSPWEHTLGAALGQAREA
LPCAAQGLCAPHEHISLWPGGLQAGCGNSS*GN
*RFYEL*EY*RPGCWHQNLKR*LDVSVLYVSGYQ
DASVQKVCLPWVYVFTFFKKHFCRKNN*IPFLE
TYCRFCALTTSPYVRFVKSVL*LNTETQ*THTK
*FHE*FFRCPSQLVS*SRILGVGVAEKSSLKFLL
IKKI*WNTIVCRFPFLMYIL*VFIRFVGHITYQ
LSQMSVCNCVSFTL*NFVQHK*VKKSLFFSTFS
KSRIVNIVDSFSV*CVLLFHNAVTCRNIVYLFSA
YLMS*FLKSINIPVSHSPAVP*S*LLRVVGGDW
RAHCRPRGPPGWLSTFGSWYFQSSGFQFLGFAA
LMMKCVFDASEKLSLAGYKILLQEIPSNLLFVPK
QLAYHASKFC*LQALSLGKQKNQSIISRWERFF
Y*KFIPDNSAFRKEIKCATSRGAALQLFRARAR
QDK*MGGTGGSCLRTTSGH*PLVDNCE*LGFPPP
AVQLPVL*GWTNLSSGAN*LYSPPHAPPIRSLH
LVSLLLQVDALLLILHLLQGRLGPHWTGCQDVK
AYGSFKETSWWFHAGGSAIPADLAWCLCVSTHVH
VGWGKRVYR*R*ISWGLL*TALCVRSILKLPVK
*LDYFYLGISDYRSSLMFYVQIL*PLVTVSELI
RYPLINSTDLAVY*SITNLFSRTQRM*HLYCSFP
GLLVFCTDEF*QGNCHFTCAILL*ITADF*TIF
YVNFIKIKLSTSF
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATRQEPSTHEL*QINTNPKSSLPGLQ
PLSQCNGFHEAG*TCRYAPRDMDRPRVAAYWRR
V*RLLCKEGIFE*LPSSRRPPTNGYLTTVTLHCP
PGVENALTGSLRSRDTMQTFCLFKPTRPSTAVS
WCHYYAASGSLVEGAGDVSEDTELDGTTFLFIT
TQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQDFV
*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVNNF
CIKILRTYGLFSEDYVTPAVETEPANLKSCLSL
FLEITEFLNRETCDILPPFPTIASLTFLNYF*YQ
KSSFEMELIKRAEGLLPACIDIPVPFVNIYVPL
*IQLHLWQNFRLFLRLSSSLFVMQLQSGLRCID
LVQCIFMIK*N*VRTRVNICLYLAQFERSVINWE
AFGVGFHSISTSMLLGSILKRQ*Q**QQT*VLR
PFVLLAFLVAGFPMVTGCTVSIRSQRATVSITA
ESSCSIQLTPSWELAQAWGRASDGHLLGLLHFSP
THSPLASLL*IHFETGLIPLPPAP*KNNSGQKS
VFFHFSRTVGYCQATCDPSHVVRVLFLCACSL*
VQWKEATHWSVISEAADAQGDPRKSQVREQ*K*G
GKTIL*TL*LLKFLKTPSLNNF*KK*LNFQMSK
QCHQLVFCPIEEPACSRYLN*VEKSKHFYLHNL
KNIYVYIAYSLFPLGRDDFNPNTLTLKNFLSPRI
SLGL*LIFKAVLELILFPDVSRAHW*GHTKPTV
TSSGRIAAVGLLDTHIHQRCIWIWAPPPRIPVL
TCQSPD*STLLCFLSPAAPGSTHWVQPWARHGRP
CPVLPRGCVHHMSTFPSGLAASRLAVETVPEEI
RDSMNCRSIKDQAVGTRT*SDDWMSLYCMYLVI
KMPLCRKYASRGYTFLPFLKNIFVEKIIKSPFWK
LTAGFVP*QPLPM*GL*KVSCDLTQKRNKHTQN
SFMSDSSDALPNWLVDQEFWGWGLRRNQV*NSF
*LKKYSGIQLSAVSPS*CIYCEYLLDS*VILLIN
*AKCLCAIVFPLPCKILYSINK*KNHCFSQLFQ
NQGL*IL*ILFLCDVSYCFIML*LVEILYIYFL
LI*CLNF*KVLTSLSPTPLPSHEVNS*ELSGVTG
ELIADHVVLQGGSPPSGPGISSQVGFNSWALPP
L**SVCLMPVRNSVWQATKFYSKKYPATFCLFQ
SN*LIMQANFADSRLYL*ENKKTKVLSAGGKDFS
IENLSLTTQRLEKK*NVPLPEVLHCSCSGLGPG
RTSEWVGQVAPA*GPPQATNPLWTTVSSWVFPH
LLCNFLCFEVGLTCLQELINCTALPTPHPYGHCI
WSACFFRSMPSF*YSISFRGGWGPTGLGVKM*K
LMGALRRLHGGSMQVVLPSLLI*PGACVCPLTY
TWGGGNVSTDDAKSVGVYSKQHCV*EASSSSQLS
NLTTFIWEFQTIEALLCFMSRFCDH*LLYQNSS
GTHL*IALIWLYTDPSLTCFLGPSVCSICIAVS
LAYLCFALMNFDRVIATLLVQYCCK*LQIFKQSF
MLIL*K*NFQLV
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