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Sequence BCL2L11.nAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTAT
TGGAGACGAGTTTAACGCTTACTATGCAAGGAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAA
GCGTTTGAGACGGAGCTGTGGAGGCTGAATCCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACG
AATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCT
TGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACAC
CGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAA
TATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGA
AATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAAC
TGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATT
GCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATA
TACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGT
GATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTAT
CTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGC
AATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCAT
CAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCT
GATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCAC
CAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGT
GAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCA
AGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACT
TTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGT
GGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAAT
ACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTC
GAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTG
GATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACA
CACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCT
CCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGA
CTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATT
TTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTG
ACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTG
GGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAG
TATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATA
AGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCT
GTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCAT
GAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCA
GTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTC
CAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAA
ACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGG
TGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTT
GTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACA
GCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTT
GGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGAT
TTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCAT
TGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGAT
TCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGG
ACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATAC
TGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRI
GDEFNAYYARRLEK*RKLSCSCHVFSPLKGSGE
AFETELWRLNP*RRR*ERHRYF*IITKQPKTTH
EWLSYDCYVTLSAWCGECIDRFFAEPRYHADILL
VQTNKTQHRGLLVPLLCSQRFSCGGGR*RFRRH
RAGWDYLSVHHHTAEFLMEVCCECKGGSILCFL
IYKPWFFGAGFCVRMVFTCSVFSPSPSIRFFKKE
METF*PICE*LLY*NFKNLRPILRGLCNPCSGN
*AS*LKKLP*FIFRDYRIFKQGDV*YTPSLPYY
CLSDLFKLFLIPKEFF*NGTD*KGRGSVASLH*Y
TSPICKYLRTFINSVASVAKFQTIFASFLITFC
DATPVWTQMHRFGPVYFHDKVKLSQNKS*YLPV
SCTVRAICY*LGSIWCWFSFHFDEHVIGKYSEEA
IAVITTDLSATPLCAAGFSGCRLSHGHRMHCQH
QVPEGHRVHYSRVQLQHPAHALMGIGTGLGQGF
*WPFAWPPAF*SNSQSTSFTPLNSL*NRPHPTST
STIEE*FWAEVCFFSFFQDSWILSGHL*PQPCS
EGALSLCLLLMSAVEGSHTLVSHFRGSRCPGRP
KKESG*GAVKVRREDNSVNSVTLKIFENSIVKQL
LKEITKFSNE*AVPPTSVLPDRRASMFTLFKLG
GKI*TFLSS*FKKYICIYCIFTFSFR*R*FQSK
YSYFKKFPFPKNLLGTLTYF*SCVGAHLVP*CVS
SPLVGSYKAHGYKQW*DCSRGPAGHTHTPKMYL
DLGTPSQDPCTHVPVS*LEHFTLFPQPCSPWEH
TLGAALGQAREALPCAAQGLCAPHEHISLWPGGL
QAGCGNSS*GN*RFYEL*EY*RPGCWHQNLKR*
LDVSVLYVSGYQDASVQKVCLPWVYVFTFFKKH
FCRKNN*IPFLETYCRFCALTTSPYVRFVKSVL*
LNTETQ*THTK*FHE*FFRCPSQLVS*SRILGV
GVAEKSSLKFLLIKKI*WNTIVCRFPFLMYIL*
VFIRFVGHITYQLSQMSVCNCVSFTL*NFVQHK*
VKKSLFFSTFSKSRIVNIVDSFSV*CVLLFHNA
VTCRNIVYLFSAYLMS*FLKSINIPVSHSPAVP
*S*LLRVVGGDWRAHCRPRGPPGWLSTFGSWYFQ
SSGFQFLGFAALMMKCVFDASEKLSLAGYKILL
QEIPSNLLFVPKQLAYHASKFC*LQALSLGKQK
NQSIISRWERFFY*KFIPDNSAFRKEIKCATSRG
AALQLFRARARQDK*MGGTGGSCLRTTSGH*PL
VDNCE*LGFPPPAVQLPVL*GWTNLSSGAN*LY
SPPHAPPIRSLHLVSLLLQVDALLLILHLLQGRL
GPHWTGCQDVKAYGSFKETSWWFHAGGSAIPAD
LAWCLCVSTHVHVGWGKRVYR*R*ISWGLL*TA
LCVRSILKLPVK*LDYFYLGISDYRSSLMFYVQI
L*PLVTVSELIRYPLINSTDLAVY*SITNLFSR
TQRM*HLYCSFPGLLVFCTDEF*QGNCHFTCAI
LL*ITADF*TIFYVNFIKIKLSTSF
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKLP*GRLNLQICAQRYGSPKSCGV
LETSLTLTMQGG*RNRGSCRVVVMYSVHLRAVGK
RLRRSCGG*ILEGGGERGTGIFE*LPSSRRPPT
NGYLTTVTLHCPPGVENALTGSLRSRDTMQTFC
LFKPTRPSTAVSWCHYYAASGSLVEGAGDVSEDT
ELDGTTFLFITTQQNF*WKFVVNVKEGAFFAF*
YTNHGFLEQDFV*EWCLHAVCFPPHLQ*GFSKR
KWKLFNQFVNNFCIKILRTYGLFSEDYVTPAVET
EPANLKSCLSLFLEITEFLNRETCDILPPFPTI
ASLTFLNYF*YQKSSFEMELIKRAEGLLPACID
IPVPFVNIYVPL*IQLHLWQNFRLFLRLSSSLFV
MQLQSGLRCIDLVQCIFMIK*N*VRTRVNICLY
LAQFERSVINWEAFGVGFHSISTSMLLGSILKR
Q*Q**QQT*VLRPFVLLAFLVAGFPMVTGCTVSI
RSQRATVSITAESSCSIQLTPSWELAQAWGRAS
DGHLLGLLHFSPTHSPLASLL*IHFETGLIPLP
PAP*KNNSGQKSVFFHFSRTVGYCQATCDPSHVV
RVLFLCACSL*VQWKEATHWSVISEAADAQGDP
RKSQVREQ*K*GGKTIL*TL*LLKFLKTPSLNN
F*KK*LNFQMSKQCHQLVFCPIEEPACSRYLN*V
EKSKHFYLHNLKNIYVYIAYSLFPLGRDDFNPN
TLTLKNFLSPRISLGL*LIFKAVLELILFPDVS
RAHW*GHTKPTVTSSGRIAAVGLLDTHIHQRCIW
IWAPPPRIPVLTCQSPD*STLLCFLSPAAPGST
HWVQPWARHGRPCPVLPRGCVHHMSTFPSGLAA
SRLAVETVPEEIRDSMNCRSIKDQAVGTRT*SDD
WMSLYCMYLVIKMPLCRKYASRGYTFLPFLKNI
FVEKIIKSPFWKLTAGFVP*QPLPM*GL*KVSC
DLTQKRNKHTQNSFMSDSSDALPNWLVDQEFWGW
GLRRNQV*NSF*LKKYSGIQLSAVSPS*CIYCE
YLLDS*VILLIN*AKCLCAIVFPLPCKILYSIN
K*KNHCFSQLFQNQGL*IL*ILFLCDVSYCFIML
*LVEILYIYFLLI*CLNF*KVLTSLSPTPLPSH
EVNS*ELSGVTGELIADHVVLQGGSPPSGPGIS
SQVGFNSWALPPL**SVCLMPVRNSVWQATKFYS
KKYPATFCLFQSN*LIMQANFADSRLYL*ENKK
TKVLSAGGKDFSIENLSLTTQRLEKK*NVPLPE
VLHCSCSGLGPGRTSEWVGQVAPA*GPPQATNPL
WTTVSSWVFPHLLCNFLCFEVGLTCLQELINCT
ALPTPHPYGHCIWSACFFRSMPSF*YSISFRGG
WGPTGLGVKM*KLMGALRRLHGGSMQVVLPSLLI
*PGACVCPLTYTWGGGNVSTDDAKSVGVYSKQH
CV*EASSSSQLSNLTTFIWEFQTIEALLCFMSR
FCDH*LLYQNSSGTHL*IALIWLYTDPSLTCFLG
PSVCSICIAVSLAYLCFALMNFDRVIATLLVQY
CCK*LQIFKQSFMLIL*K*NFQLV
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATSFHEAG*TCRYAPRDMDRPRVAAY
WRRV*RLLCKEVREIEEVVV*LSCIQST*GQWG
SV*DGAVEAESLKEEVREAQVFLNNYQAAEDHPR
MVILRLLRYIVRLVWRMH*QVLCGAEIPCRHFA
CSNQQDPAPRSPGAIIMQPAVLLWRGQVTFQKT
PSWMGLPFCSSPHSRISNGSLL*M*RREHSLLFN
IQTMVFWSRILCKNGVYMQCVFPLTFNKVFQKG
NGNFLTNL*ITFVLKF*EPTAYSQRIM*PLQWK
LSQLT*KAALVYF*RLQNF*TGRRVIYSLPSLLL
PL*PF*IIFNTKRVLLKWN*LKGQRVCCQPALI
YQSHL*IFTYLYKFSCICGKISDYFCVFPHHFL
*CNSSLDSDA*IWSSVFS**SEIESEQELISACI
LHSSSDLLLTGKHLVLVFIPFRRACYWEVF*RG
NSSNNNRLKCYAPLCCWLFWLQAFPWSQDALSA
SGPRGPPCPLQQSPAAASSSRPHGNWHRPGAGLL
MAICLASCILVQLTVH*LHSFKFTLKQASSHFH
QHHRRIILGRSLFFFIFPGQLDIVRPLVTPAM*
*GCSFSVPAPYECSGRKPHTGQSFQRQQMPRETQ
ERVRLGSSESEEGRQFCELCNS*NF*KLHR*TT
FKRNN*IFK*VSSATN*CFAR*KSQHVHVI*IR
WKNLNIFIFII*KIYMYILHIHFFL*VEMISIQI
LLL*KISFPQESPWDFDLFLKLCWSSSCSLMCL
EPIGRVIQSPRLQAVVGLQPWACWTHTYTKDVF
GSGHPLPGSLYSRASLLTRALYSVSSALQPLGAH
TGCSPGPGTGGPALCCPGAVCTT*AHFPLAWRP
PGWLWKQFLRKLEIL*IVGVLKTRLLAPELKAM
TGCLCTVCIWLSRCLCAESMPPVGIRFYLF*KTF
L*KK*LNPLFGNLLQVLCLDNLSLCEVCKKCPV
T*HRNAINTHKIVS*VILQMPFPTG*LIKNFGG
GGCGEIKFKIPSD*KNIVEYNCLPFPLLNVYIVS
IY*IRRSYYLSTEPNVCVQLCFLYLVKFCTA*I
SKKITVFLNFFKIKDCKYCRFFFCVMCPTVS*C
CNL*KYCIFIFCLFNVLISEKY*HPCLPLPCRPM
KLTPESCRG*LESSLQTTWSSRVALHLRVLVFP
VKWVSILGLCRPYDEVCV*CQ*ETQSGRLQNST
PRNTQQPSVCSKATSLSCKQILLTPGFIFRKTKK
PKYYQQVGKIFLLKIYP*QLSV*KRNKMCHFQR
CCIAVVQG*GQAGQVNGWDRWLLPKDHLRPLTP
CGQL*VAGFSPTCCATSCALRLD*LVFRS*LTVQ
PSPRPTHTVTAFGQPASSGRCPPSDTPSPSGEV
GAPLDWVSRCESLWEL*GDFMVVPCRWFCHPC*
FSLVPVCVHSRTRGVGETCLQMTLNQLGSTLNSI
VCKKHPQAPS*VT*LLLFGNFRL*KLSYVLCPD
SVTTSYCIRTHQVPTYK*H*SGCILIHH*PVF*
DPAYVAFVLQFPWLTCVLH**ILTG*LPLYLCNT
AVNNCRFLNNLLC*FYKNKTFN*F
Sequence BCL2L11.mAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTAT
TGGAGACGAGTTTAACGCTTACTATGCAAGGAGGCTGGCAAAACTCCTGGCATCCTCCACCTGACATAAACCAGTTCACAGAACATTCCAGCCTAGATCT
GAAATGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGACGGAGCTGTGGAGGCTGA
ATCCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTAC
ATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGC
GGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTC
ATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGG
ATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAA
TAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTT
AGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTT
AATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGT
ACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGC
ATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTA
ACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGT
GCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATT
ACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATT
TTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCA
GAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCC
TTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAA
AGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAAT
GAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCAT
AATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCC
CAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCC
CACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCT
GTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACG
GGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGA
GGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTG
GTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTT
TTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACAC
ACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAAT
TCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTAC
TTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACT
TTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTAT
TTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGG
TGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTT
GCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTG
TTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAG
ATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGG
GCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTC
CCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTC
ACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGAT
GTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTC
ACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCC
AGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAA
CTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCA
GTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAAC
AATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRI
GDEFNAYYARRLAKLLASST*HKPVHRTFQPRS
EMLEK*RKLSCSCHVFSPLKGSGEAFETELWRL
NP*RRR*ERHRYF*IITKQPKTTHEWLSYDCYVT
LSAWCGECIDRFFAEPRYHADILLVQTNKTQHR
GLLVPLLCSQRFSCGGGR*RFRRHRAGWDYLSV
HHHTAEFLMEVCCECKGGSILCFLIYKPWFFGAG
FCVRMVFTCSVFSPSPSIRFFKKEMETF*PICE
*LLY*NFKNLRPILRGLCNPCSGN*AS*LKKLP
*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKLFL
IPKEFF*NGTD*KGRGSVASLH*YTSPICKYLR
TFINSVASVAKFQTIFASFLITFCDATPVWTQM
HRFGPVYFHDKVKLSQNKS*YLPVSCTVRAICY*
LGSIWCWFSFHFDEHVIGKYSEEAIAVITTDLS
ATPLCAAGFSGCRLSHGHRMHCQHQVPEGHRVH
YSRVQLQHPAHALMGIGTGLGQGF*WPFAWPPAF
*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*FWA
EVCFFSFFQDSWILSGHL*PQPCSEGALSLCLL
LMSAVEGSHTLVSHFRGSRCPGRPKKESG*GAVK
VRREDNSVNSVTLKIFENSIVKQLLKEITKFSN
E*AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS
*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFPFP
KNLLGTLTYF*SCVGAHLVP*CVSSPLVGSYKA
HGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQDP
CTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQAR
EALPCAAQGLCAPHEHISLWPGGLQAGCGNSS*
GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLYVS
GYQDASVQKVCLPWVYVFTFFKKHFCRKNN*IPF
LETYCRFCALTTSPYVRFVKSVL*LNTETQ*TH
TK*FHE*FFRCPSQLVS*SRILGVGVAEKSSLK
FLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGHIT
YQLSQMSVCNCVSFTL*NFVQHK*VKKSLFFST
FSKSRIVNIVDSFSV*CVLLFHNAVTCRNIVYL
FSAYLMS*FLKSINIPVSHSPAVP*S*LLRVVGG
DWRAHCRPRGPPGWLSTFGSWYFQSSGFQFLGF
AALMMKCVFDASEKLSLAGYKILLQEIPSNLLF
VPKQLAYHASKFC*LQALSLGKQKNQSIISRWER
FFY*KFIPDNSAFRKEIKCATSRGAALQLFRAR
ARQDK*MGGTGGSCLRTTSGH*PLVDNCE*LGF
PPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPIRS
LHLVSLLLQVDALLLILHLLQGRLGPHWTGCQD
VKAYGSFKETSWWFHAGGSAIPADLAWCLCVST
HVHVGWGKRVYR*R*ISWGLL*TALCVRSILKLP
VK*LDYFYLGISDYRSSLMFYVQIL*PLVTVSE
LIRYPLINSTDLAVY*SITNLFSRTQRM*HLYC
SFPGLLVFCTDEF*QGNCHFTCAILL*ITADF*T
IFYVNFIKIKLSTSF
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKLP*GRLNLQICAQRYGSPKSCGV
LETSLTLTMQGGWQNSWHPPPDINQFTEHSSLDL
KC*RNRGSCRVVVMYSVHLRAVGKRLRRSCGG*
ILEGGGERGTGIFE*LPSSRRPPTNGYLTTVTL
HCPPGVENALTGSLRSRDTMQTFCLFKPTRPSTA
VSWCHYYAASGSLVEGAGDVSEDTELDGTTFLF
ITTQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQ
DFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVN
NFCIKILRTYGLFSEDYVTPAVETEPANLKSCL
SLFLEITEFLNRETCDILPPFPTIASLTFLNYF
*YQKSSFEMELIKRAEGLLPACIDIPVPFVNIYV
PL*IQLHLWQNFRLFLRLSSSLFVMQLQSGLRC
IDLVQCIFMIK*N*VRTRVNICLYLAQFERSVI
NWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT*V
LRPFVLLAFLVAGFPMVTGCTVSIRSQRATVSI
TAESSCSIQLTPSWELAQAWGRASDGHLLGLLH
FSPTHSPLASLL*IHFETGLIPLPPAP*KNNSGQ
KSVFFHFSRTVGYCQATCDPSHVVRVLFLCACS
L*VQWKEATHWSVISEAADAQGDPRKSQVREQ*
K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNFQM
SKQCHQLVFCPIEEPACSRYLN*VEKSKHFYLH
NLKNIYVYIAYSLFPLGRDDFNPNTLTLKNFLS
PRISLGL*LIFKAVLELILFPDVSRAHW*GHTKP
TVTSSGRIAAVGLLDTHIHQRCIWIWAPPPRIP
VLTCQSPD*STLLCFLSPAAPGSTHWVQPWARH
GRPCPVLPRGCVHHMSTFPSGLAASRLAVETVPE
EIRDSMNCRSIKDQAVGTRT*SDDWMSLYCMYL
VIKMPLCRKYASRGYTFLPFLKNIFVEKIIKSP
FWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNKHT
QNSFMSDSSDALPNWLVDQEFWGWGLRRNQV*N
SF*LKKYSGIQLSAVSPS*CIYCEYLLDS*VIL
LIN*AKCLCAIVFPLPCKILYSINK*KNHCFSQL
FQNQGL*IL*ILFLCDVSYCFIML*LVEILYIY
FLLI*CLNF*KVLTSLSPTPLPSHEVNS*ELSG
VTGELIADHVVLQGGSPPSGPGISSQVGFNSWAL
PPL**SVCLMPVRNSVWQATKFYSKKYPATFCL
FQSN*LIMQANFADSRLYL*ENKKTKVLSAGGK
DFSIENLSLTTQRLEKK*NVPLPEVLHCSCSGLG
PGRTSEWVGQVAPA*GPPQATNPLWTTVSSWVF
PHLLCNFLCFEVGLTCLQELINCTALPTPHPYG
HCIWSACFFRSMPSF*YSISFRGGWGPTGLGVKM
*KLMGALRRLHGGSMQVVLPSLLI*PGACVCPL
TYTWGGGNVSTDDAKSVGVYSKQHCV*EASSSS
QLSNLTTFIWEFQTIEALLCFMSRFCDH*LLYQN
SSGTHL*IALIWLYTDPSLTCFLGPSVCSICIA
VSLAYLCFALMNFDRVIATLLVQYCCK*LQIFK
QSFMLIL*K*NFQLV
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATSFHEAG*TCRYAPRDMDRPRVAAY
WRRV*RLLCKEAGKTPGILHLT*TSSQNIPA*I
*NVREIEEVVV*LSCIQST*GQWGSV*DGAVEAE
SLKEEVREAQVFLNNYQAAEDHPRMVILRLLRY
IVRLVWRMH*QVLCGAEIPCRHFACSNQQDPAP
RSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPFCS
SPHSRISNGSLL*M*RREHSLLFNIQTMVFWSR
ILCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*
ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KAAL
VYF*RLQNF*TGRRVIYSLPSLLLPL*PF*IIF
NTKRVLLKWN*LKGQRVCCQPALIYQSHL*IFT
YLYKFSCICGKISDYFCVFPHHFL*CNSSLDSDA
*IWSSVFS**SEIESEQELISACILHSSSDLLL
TGKHLVLVFIPFRRACYWEVF*RGNSSNNNRLK
CYAPLCCWLFWLQAFPWSQDALSASGPRGPPCPL
QQSPAAASSSRPHGNWHRPGAGLLMAICLASCI
LVQLTVH*LHSFKFTLKQASSHFHQHHRRIILG
RSLFFFIFPGQLDIVRPLVTPAM**GCSFSVPAP
YECSGRKPHTGQSFQRQQMPRETQERVRLGSSE
SEEGRQFCELCNS*NF*KLHR*TTFKRNN*IFK
*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFIFI
I*KIYMYILHIHFFL*VEMISIQILLL*KISFP
QESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQS
PRLQAVVGLQPWACWTHTYTKDVFGSGHPLPGSL
YSRASLLTRALYSVSSALQPLGAHTGCSPGPGT
GGPALCCPGAVCTT*AHFPLAWRPPGWLWKQFL
RKLEIL*IVGVLKTRLLAPELKAMTGCLCTVCIW
LSRCLCAESMPPVGIRFYLF*KTFL*KK*LNPL
FGNLLQVLCLDNLSLCEVCKKCPVT*HRNAINT
HKIVS*VILQMPFPTG*LIKNFGGGGCGEIKFKI
PSD*KNIVEYNCLPFPLLNVYIVSIY*IRRSYY
LSTEPNVCVQLCFLYLVKFCTA*ISKKITVFLN
FFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCIFI
FCLFNVLISEKY*HPCLPLPCRPMKLTPESCRG
*LESSLQTTWSSRVALHLRVLVFPVKWVSILGL
CRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVC
SKATSLSCKQILLTPGFIFRKTKKPKYYQQVGK
IFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*
GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAGFS
PTCCATSCALRLD*LVFRS*LTVQPSPRPTHTV
TAFGQPASSGRCPPSDTPSPSGEVGAPLDWVSR
CESLWEL*GDFMVVPCRWFCHPC*FSLVPVCVHS
RTRGVGETCLQMTLNQLGSTLNSIVCKKHPQAP
S*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIR
THQVPTYK*H*SGCILIHH*PVF*DPAYVAFVLQ
FPWLTCVLH**ILTG*LPLYLCNTAVNNCRFLN
NLLC*FYKNKTFN*F
Sequence BCL2L11.kAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTAT
TGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGT
TACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCAC
CGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTG
TTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGC
AGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGT
GAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGC
CTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATT
TTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTA
CGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGA
TGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTA
TTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTA
AGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCC
ATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGC
ATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGG
GCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGC
TCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGT
GAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCA
AATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTT
CATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTT
CCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAA
GCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATC
CCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGC
ACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCC
TGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTAT
CTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCC
CTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACA
CACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAA
AATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATAT
TACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCA
ACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATT
TATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGG
GGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGC
TTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGT
TTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGA
AAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCT
AGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTT
TTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACG
GTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAA
GATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCA
CTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCT
CCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCA
GAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATT
GCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTA
AACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQASMRQAEPADMRPEIWIAQELRRI
GDEFNAYYARRVFLNNYQAAEDHPRMVILRLLR
YIVRLVWRMH*QVLCGAEIPCRHFACSNQQDPA
PRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPFC
SSPHSRISNGSLL*M*RREHSLLFNIQTMVFWS
RILCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL
*ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KAA
LVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*II
FNTKRVLLKWN*LKGQRVCCQPALIYQSHL*IF
TYLYKFSCICGKISDYFCVFPHHFL*CNSSLDSD
A*IWSSVFS**SEIESEQELISACILHSSSDLL
LTGKHLVLVFIPFRRACYWEVF*RGNSSNNNRL
KCYAPLCCWLFWLQAFPWSQDALSASGPRGPPCP
LQQSPAAASSSRPHGNWHRPGAGLLMAICLASC
ILVQLTVH*LHSFKFTLKQASSHFHQHHRRIIL
GRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVPA
PYECSGRKPHTGQSFQRQQMPRETQERVRLGSS
ESEEGRQFCELCNS*NF*KLHR*TTFKRNN*IF
K*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFIF
II*KIYMYILHIHFFL*VEMISIQILLL*KISF
PQESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQ
SPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPGS
LYSRASLLTRALYSVSSALQPLGAHTGCSPGPG
TGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQF
LRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVCI
WLSRCLCAESMPPVGIRFYLF*KTFL*KK*LNP
LFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAIN
THKIVS*VILQMPFPTG*LIKNFGGGGCGEIKFK
IPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRSY
YLSTEPNVCVQLCFLYLVKFCTA*ISKKITVFL
NFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCIF
IFCLFNVLISEKY*HPCLPLPCRPMKLTPESCR
G*LESSLQTTWSSRVALHLRVLVFPVKWVSILG
LCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPSV
CSKATSLSCKQILLTPGFIFRKTKKPKYYQQVG
KIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG
*GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAGF
SPTCCATSCALRLD*LVFRS*LTVQPSPRPTHT
VTAFGQPASSGRCPPSDTPSPSGEVGAPLDWVS
RCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCVH
SRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQA
PS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCI
RTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFVL
QFPWLTCVLH**ILTG*LPLYLCNTAVNNCRFL
NNLLC*FYKNKTFN*F
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKLP*GRLNLQICAQRYGSPKSCGV
LETSLTLTMQGGYF*IITKQPKTTHEWLSYDCYV
TLSAWCGECIDRFFAEPRYHADILLVQTNKTQH
RGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYLS
VHHHTAEFLMEVCCECKGGSILCFLIYKPWFFGA
GFCVRMVFTCSVFSPSPSIRFFKKEMETF*PIC
E*LLY*NFKNLRPILRGLCNPCSGN*AS*LKKL
P*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKLF
LIPKEFF*NGTD*KGRGSVASLH*YTSPICKYL
RTFINSVASVAKFQTIFASFLITFCDATPVWTQ
MHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAICY
*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTDL
SATPLCAAGFSGCRLSHGHRMHCQHQVPEGHRV
HYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPPA
F*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*FW
AEVCFFSFFQDSWILSGHL*PQPCSEGALSLCL
LLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GAV
KVRREDNSVNSVTLKIFENSIVKQLLKEITKFS
NE*AVPPTSVLPDRRASMFTLFKLGGKI*TFLS
S*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFPF
PKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSYK
AHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQD
PCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQA
REALPCAAQGLCAPHEHISLWPGGLQAGCGNSS
*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLYV
SGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*IP
FLETYCRFCALTTSPYVRFVKSVL*LNTETQ*T
HTK*FHE*FFRCPSQLVS*SRILGVGVAEKSSL
KFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGHI
TYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFFS
TFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIVY
LFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVVG
GDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFLG
FAALMMKCVFDASEKLSLAGYKILLQEIPSNLL
FVPKQLAYHASKFC*LQALSLGKQKNQSIISRWE
RFFY*KFIPDNSAFRKEIKCATSRGAALQLFRA
RARQDK*MGGTGGSCLRTTSGH*PLVDNCE*LG
FPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPIR
SLHLVSLLLQVDALLLILHLLQGRLGPHWTGCQ
DVKAYGSFKETSWWFHAGGSAIPADLAWCLCVS
THVHVGWGKRVYR*R*ISWGLL*TALCVRSILKL
PVK*LDYFYLGISDYRSSLMFYVQIL*PLVTVS
ELIRYPLINSTDLAVY*SITNLFSRTQRM*HLY
CSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF*
TIFYVNFIKIKLSTSF
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATSFHEAG*TCRYAPRDMDRPRVAAY
WRRV*RLLCKEGIFE*LPSSRRPPTNGYLTTVT
LHCPPGVENALTGSLRSRDTMQTFCLFKPTRPST
AVSWCHYYAASGSLVEGAGDVSEDTELDGTTFL
FITTQQNF*WKFVVNVKEGAFFAF*YTNHGFLE
QDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFV
NNFCIKILRTYGLFSEDYVTPAVETEPANLKSC
LSLFLEITEFLNRETCDILPPFPTIASLTFLNY
F*YQKSSFEMELIKRAEGLLPACIDIPVPFVNIY
VPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGLR
CIDLVQCIFMIK*N*VRTRVNICLYLAQFERSV
INWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT*
VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATVS
ITAESSCSIQLTPSWELAQAWGRASDGHLLGLL
HFSPTHSPLASLL*IHFETGLIPLPPAP*KNNSG
QKSVFFHFSRTVGYCQATCDPSHVVRVLFLCAC
SL*VQWKEATHWSVISEAADAQGDPRKSQVREQ
*K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNFQ
MSKQCHQLVFCPIEEPACSRYLN*VEKSKHFYL
HNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNFL
SPRISLGL*LIFKAVLELILFPDVSRAHW*GHTK
PTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPRI
PVLTCQSPD*STLLCFLSPAAPGSTHWVQPWAR
HGRPCPVLPRGCVHHMSTFPSGLAASRLAVETVP
EEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCMY
LVIKMPLCRKYASRGYTFLPFLKNIFVEKIIKS
PFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNKH
TQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV*
NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*VI
LLIN*AKCLCAIVFPLPCKILYSINK*KNHCFSQ
LFQNQGL*IL*ILFLCDVSYCFIML*LVEILYI
YFLLI*CLNF*KVLTSLSPTPLPSHEVNS*ELS
GVTGELIADHVVLQGGSPPSGPGISSQVGFNSWA
LPPL**SVCLMPVRNSVWQATKFYSKKYPATFC
LFQSN*LIMQANFADSRLYL*ENKKTKVLSAGG
KDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSGL
GPGRTSEWVGQVAPA*GPPQATNPLWTTVSSWV
FPHLLCNFLCFEVGLTCLQELINCTALPTPHPY
GHCIWSACFFRSMPSF*YSISFRGGWGPTGLGVK
M*KLMGALRRLHGGSMQVVLPSLLI*PGACVCP
LTYTWGGGNVSTDDAKSVGVYSKQHCV*EASSS
SQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLYQ
NSSGTHL*IALIWLYTDPSLTCFLGPSVCSICI
AVSLAYLCFALMNFDRVIATLLVQYCCK*LQIF
KQSFMLIL*K*NFQLV
Sequence BCL2L11.qAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTAACTGGGACTAGAAACAGCTCCATCACCCAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCG
TATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGATGCCTCTTCCACCTGATTAAGAACCACTGTAGCAGACGCAGACTTATTGGACACTAGGCGGG
AGGCCAGCTCTGCAGACAGCAGGTCTCAGGAAGACGGTCAAGGCATGGCTGCTGATGATCCGCTTATGGGTATTTTTGAATAATTACCAAGCAGCCGAAG
ACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAG
ACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTT
CAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTT
TGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTT
TCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTG
CAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTT
CCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCC
TGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCAT
CACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATAT
CTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATT
CTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCA
CTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGG
CAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATC
CCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCA
GCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCA
GGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCG
TTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATT
TAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTT
CAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCT
GATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAA
GATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCC
TGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGC
CTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTT
AAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTT
AAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAA
GTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAAT
TTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTAT
ATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTAC
AGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTT
TCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCT
GCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCT
GGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAA
AATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGA
AAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCA
CTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCA
CTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAAT
TAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTC
AGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCAT
CCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTC
TAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTT
ATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCT
GTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACT
TGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ANWD*KQLHHPASMRQAEPADMRPEIWIAQELRR
IGDEFNAYYARRMPLPPD*EPL*QTQTYWTLGG
RPALQTAGLRKTVKAWLLMIRLWVFLNNYQAAE
DHPRMVILRLLRYIVRLVWRMH*QVLCGAEIPCR
HFACSNQQDPAPRSPGAIIMQPAVLLWRGQVTF
QKTPSWMGLPFCSSPHSRISNGSLL*M*RREHS
LLFNIQTMVFWSRILCKNGVYMQCVFPLTFNKVF
QKGNGNFLTNL*ITFVLKF*EPTAYSQRIM*PL
QWKLSQLT*KAALVYF*RLQNF*TGRRVIYSLP
SLLLPL*PF*IIFNTKRVLLKWN*LKGQRVCCQP
ALIYQSHL*IFTYLYKFSCICGKISDYFCVFPH
HFL*CNSSLDSDA*IWSSVFS**SEIESEQELI
SACILHSSSDLLLTGKHLVLVFIPFRRACYWEVF
*RGNSSNNNRLKCYAPLCCWLFWLQAFPWSQDA
LSASGPRGPPCPLQQSPAAASSSRPHGNWHRPG
AGLLMAICLASCILVQLTVH*LHSFKFTLKQASS
HFHQHHRRIILGRSLFFFIFPGQLDIVRPLVTP
AM**GCSFSVPAPYECSGRKPHTGQSFQRQQMP
RETQERVRLGSSESEEGRQFCELCNS*NF*KLHR
*TTFKRNN*IFK*VSSATN*CFAR*KSQHVHVI
*IRWKNLNIFIFII*KIYMYILHIHFFL*VEMI
SIQILLL*KISFPQESPWDFDLFLKLCWSSSCSL
MCLEPIGRVIQSPRLQAVVGLQPWACWTHTYTK
DVFGSGHPLPGSLYSRASLLTRALYSVSSALQP
LGAHTGCSPGPGTGGPALCCPGAVCTT*AHFPLA
WRPPGWLWKQFLRKLEIL*IVGVLKTRLLAPEL
KAMTGCLCTVCIWLSRCLCAESMPPVGIRFYLF
*KTFL*KK*LNPLFGNLLQVLCLDNLSLCEVCKK
CPVT*HRNAINTHKIVS*VILQMPFPTG*LIKN
FGGGGCGEIKFKIPSD*KNIVEYNCLPFPLLNV
YIVSIY*IRRSYYLSTEPNVCVQLCFLYLVKFCT
A*ISKKITVFLNFFKIKDCKYCRFFFCVMCPTV
S*CCNL*KYCIFIFCLFNVLISEKY*HPCLPLP
CRPMKLTPESCRG*LESSLQTTWSSRVALHLRVL
VFPVKWVSILGLCRPYDEVCV*CQ*ETQSGRLQ
NSTPRNTQQPSVCSKATSLSCKQILLTPGFIFR
KTKKPKYYQQVGKIFLLKIYP*QLSV*KRNKMCH
FQRCCIAVVQG*GQAGQVNGWDRWLLPKDHLRP
LTPCGQL*VAGFSPTCCATSCALRLD*LVFRS*
LTVQPSPRPTHTVTAFGQPASSGRCPPSDTPSPS
GEVGAPLDWVSRCESLWEL*GDFMVVPCRWFCH
PC*FSLVPVCVHSRTRGVGETCLQMTLNQLGST
LNSIVCKKHPQAPS*VT*LLLFGNFRL*KLSYVL
CPDSVTTSYCIRTHQVPTYK*H*SGCILIHH*P
VF*DPAYVAFVLQFPWLTCVLH**ILTG*LPLY
LCNTAVNNCRFLNNLLC*FYKNKTFN*F
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LTGTRNSSITQLP*GRLNLQICAQRYGSPKSCG
VLETSLTLTMQGGCLFHLIKNHCSRRRLIGH*AG
GQLCRQQVSGRRSRHGC**SAYGYF*IITKQPK
TTHEWLSYDCYVTLSAWCGECIDRFFAEPRYHA
DILLVQTNKTQHRGLLVPLLCSQRFSCGGGR*RF
RRHRAGWDYLSVHHHTAEFLMEVCCECKGGSIL
CFLIYKPWFFGAGFCVRMVFTCSVFSPSPSIRF
FKKEMETF*PICE*LLY*NFKNLRPILRGLCNPC
SGN*AS*LKKLP*FIFRDYRIFKQGDV*YTPSL
PYYCLSDLFKLFLIPKEFF*NGTD*KGRGSVAS
LH*YTSPICKYLRTFINSVASVAKFQTIFASFLI
TFCDATPVWTQMHRFGPVYFHDKVKLSQNKS*Y
LPVSCTVRAICY*LGSIWCWFSFHFDEHVIGKY
SEEAIAVITTDLSATPLCAAGFSGCRLSHGHRMH
CQHQVPEGHRVHYSRVQLQHPAHALMGIGTGLG
QGF*WPFAWPPAF*SNSQSTSFTPLNSL*NRPH
PTSTSTIEE*FWAEVCFFSFFQDSWILSGHL*PQ
PCSEGALSLCLLLMSAVEGSHTLVSHFRGSRCP
GRPKKESG*GAVKVRREDNSVNSVTLKIFENSI
VKQLLKEITKFSNE*AVPPTSVLPDRRASMFTLF
KLGGKI*TFLSS*FKKYICIYCIFTFSFR*R*F
QSKYSYFKKFPFPKNLLGTLTYF*SCVGAHLVP
*CVSSPLVGSYKAHGYKQW*DCSRGPAGHTHTPK
MYLDLGTPSQDPCTHVPVS*LEHFTLFPQPCSP
WEHTLGAALGQAREALPCAAQGLCAPHEHISLW
PGGLQAGCGNSS*GN*RFYEL*EY*RPGCWHQNL
KR*LDVSVLYVSGYQDASVQKVCLPWVYVFTFF
KKHFCRKNN*IPFLETYCRFCALTTSPYVRFVK
SVL*LNTETQ*THTK*FHE*FFRCPSQLVS*SRI
LGVGVAEKSSLKFLLIKKI*WNTIVCRFPFLMY
IL*VFIRFVGHITYQLSQMSVCNCVSFTL*NFV
QHK*VKKSLFFSTFSKSRIVNIVDSFSV*CVLLF
HNAVTCRNIVYLFSAYLMS*FLKSINIPVSHSP
AVP*S*LLRVVGGDWRAHCRPRGPPGWLSTFGS
WYFQSSGFQFLGFAALMMKCVFDASEKLSLAGYK
ILLQEIPSNLLFVPKQLAYHASKFC*LQALSLG
KQKNQSIISRWERFFY*KFIPDNSAFRKEIKCA
TSRGAALQLFRARARQDK*MGGTGGSCLRTTSGH
*PLVDNCE*LGFPPPAVQLPVL*GWTNLSSGAN
*LYSPPHAPPIRSLHLVSLLLQVDALLLILHLL
QGRLGPHWTGCQDVKAYGSFKETSWWFHAGGSAI
PADLAWCLCVSTHVHVGWGKRVYR*R*ISWGLL
*TALCVRSILKLPVK*LDYFYLGISDYRSSLMF
YVQIL*PLVTVSELIRYPLINSTDLAVY*SITNL
FSRTQRM*HLYCSFPGLLVFCTDEF*QGNCHFT
CAILL*ITADF*TIFYVNFIKIKLSTSF
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
*LGLETAPSPSFHEAG*TCRYAPRDMDRPRVAA
YWRRV*RLLCKEDASST*LRTTVADADLLDTRR
EASSADSRSQEDGQGMAADDPLMGIFE*LPSSRR
PPTNGYLTTVTLHCPPGVENALTGSLRSRDTMQ
TFCLFKPTRPSTAVSWCHYYAASGSLVEGAGDV
SEDTELDGTTFLFITTQQNF*WKFVVNVKEGAFF
AF*YTNHGFLEQDFV*EWCLHAVCFPPHLQ*GF
SKRKWKLFNQFVNNFCIKILRTYGLFSEDYVTP
AVETEPANLKSCLSLFLEITEFLNRETCDILPPF
PTIASLTFLNYF*YQKSSFEMELIKRAEGLLPA
CIDIPVPFVNIYVPL*IQLHLWQNFRLFLRLSS
SLFVMQLQSGLRCIDLVQCIFMIK*N*VRTRVNI
CLYLAQFERSVINWEAFGVGFHSISTSMLLGSI
LKRQ*Q**QQT*VLRPFVLLAFLVAGFPMVTGC
TVSIRSQRATVSITAESSCSIQLTPSWELAQAWG
RASDGHLLGLLHFSPTHSPLASLL*IHFETGLI
PLPPAP*KNNSGQKSVFFHFSRTVGYCQATCDP
SHVVRVLFLCACSL*VQWKEATHWSVISEAADAQ
GDPRKSQVREQ*K*GGKTIL*TL*LLKFLKTPS
LNNF*KK*LNFQMSKQCHQLVFCPIEEPACSRY
LN*VEKSKHFYLHNLKNIYVYIAYSLFPLGRDDF
NPNTLTLKNFLSPRISLGL*LIFKAVLELILFP
DVSRAHW*GHTKPTVTSSGRIAAVGLLDTHIHQ
RCIWIWAPPPRIPVLTCQSPD*STLLCFLSPAAP
GSTHWVQPWARHGRPCPVLPRGCVHHMSTFPSG
LAASRLAVETVPEEIRDSMNCRSIKDQAVGTRT
*SDDWMSLYCMYLVIKMPLCRKYASRGYTFLPFL
KNIFVEKIIKSPFWKLTAGFVP*QPLPM*GL*K
VSCDLTQKRNKHTQNSFMSDSSDALPNWLVDQE
FWGWGLRRNQV*NSF*LKKYSGIQLSAVSPS*CI
YCEYLLDS*VILLIN*AKCLCAIVFPLPCKILY
SINK*KNHCFSQLFQNQGL*IL*ILFLCDVSYC
FIML*LVEILYIYFLLI*CLNF*KVLTSLSPTPL
PSHEVNS*ELSGVTGELIADHVVLQGGSPPSGP
GISSQVGFNSWALPPL**SVCLMPVRNSVWQAT
KFYSKKYPATFCLFQSN*LIMQANFADSRLYL*E
NKKTKVLSAGGKDFSIENLSLTTQRLEKK*NVP
LPEVLHCSCSGLGPGRTSEWVGQVAPA*GPPQA
TNPLWTTVSSWVFPHLLCNFLCFEVGLTCLQELI
NCTALPTPHPYGHCIWSACFFRSMPSF*YSISF
RGGWGPTGLGVKM*KLMGALRRLHGGSMQVVLP
SLLI*PGACVCPLTYTWGGGNVSTDDAKSVGVYS
KQHCV*EASSSSQLSNLTTFIWEFQTIEALLCF
MSRFCDH*LLYQNSSGTHL*IALIWLYTDPSLT
CFLGPSVCSICIAVSLAYLCFALMNFDRVIATLL
VQYCCK*LQIFKQSFMLIL*K*NFQLV
Sequence BCL2L11.fAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTAACTGGGACTAGAAACAGCTCCATCACCCAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCG
TATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTA
CGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAG
CACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTT
CTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGG
AGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATT
TGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGC
TGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATT
ATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATAT
TTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTC
AGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTG
TTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGAC
TTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTG
TCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCC
TGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTC
TGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCC
TGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGC
AGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTT
TCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTAT
CTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCC
TTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATAC
AAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGG
ATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCA
GGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGT
TCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATG
TATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAAT
CCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAA
ACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTT
TAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCA
TATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTC
TCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTAT
ATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGT
CGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTG
GGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTC
TGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTG
GGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGG
GCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGG
GTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCAT
ACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGT
CAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGT
CCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAA
GCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTA
TCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGT
ATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTT
TTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ANWD*KQLHHPASMRQAEPADMRPEIWIAQELRR
IGDEFNAYYARRVFLNNYQAAEDHPRMVILRLL
RYIVRLVWRMH*QVLCGAEIPCRHFACSNQQDP
APRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPF
CSSPHSRISNGSLL*M*RREHSLLFNIQTMVFW
SRILCKNGVYMQCVFPLTFNKVFQKGNGNFLTN
L*ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KA
ALVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*I
IFNTKRVLLKWN*LKGQRVCCQPALIYQSHL*I
FTYLYKFSCICGKISDYFCVFPHHFL*CNSSLDS
DA*IWSSVFS**SEIESEQELISACILHSSSDL
LLTGKHLVLVFIPFRRACYWEVF*RGNSSNNNR
LKCYAPLCCWLFWLQAFPWSQDALSASGPRGPPC
PLQQSPAAASSSRPHGNWHRPGAGLLMAICLAS
CILVQLTVH*LHSFKFTLKQASSHFHQHHRRII
LGRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVP
APYECSGRKPHTGQSFQRQQMPRETQERVRLGS
SESEEGRQFCELCNS*NF*KLHR*TTFKRNN*I
FK*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFI
FII*KIYMYILHIHFFL*VEMISIQILLL*KIS
FPQESPWDFDLFLKLCWSSSCSLMCLEPIGRVI
QSPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPG
SLYSRASLLTRALYSVSSALQPLGAHTGCSPGP
GTGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQ
FLRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVC
IWLSRCLCAESMPPVGIRFYLF*KTFL*KK*LN
PLFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAI
NTHKIVS*VILQMPFPTG*LIKNFGGGGCGEIKF
KIPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRS
YYLSTEPNVCVQLCFLYLVKFCTA*ISKKITVF
LNFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCI
FIFCLFNVLISEKY*HPCLPLPCRPMKLTPESC
RG*LESSLQTTWSSRVALHLRVLVFPVKWVSIL
GLCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPS
VCSKATSLSCKQILLTPGFIFRKTKKPKYYQQV
GKIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQ
G*GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAG
FSPTCCATSCALRLD*LVFRS*LTVQPSPRPTH
TVTAFGQPASSGRCPPSDTPSPSGEVGAPLDWV
SRCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCV
HSRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQ
APS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYC
IRTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFV
LQFPWLTCVLH**ILTG*LPLYLCNTAVNNCRF
LNNLLC*FYKNKTFN*F
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LTGTRNSSITQLP*GRLNLQICAQRYGSPKSCG
VLETSLTLTMQGGYF*IITKQPKTTHEWLSYDCY
VTLSAWCGECIDRFFAEPRYHADILLVQTNKTQ
HRGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYL
SVHHHTAEFLMEVCCECKGGSILCFLIYKPWFFG
AGFCVRMVFTCSVFSPSPSIRFFKKEMETF*PI
CE*LLY*NFKNLRPILRGLCNPCSGN*AS*LKK
LP*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKL
FLIPKEFF*NGTD*KGRGSVASLH*YTSPICKY
LRTFINSVASVAKFQTIFASFLITFCDATPVWT
QMHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAIC
Y*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTD
LSATPLCAAGFSGCRLSHGHRMHCQHQVPEGHR
VHYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPP
AF*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*F
WAEVCFFSFFQDSWILSGHL*PQPCSEGALSLC
LLLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GA
VKVRREDNSVNSVTLKIFENSIVKQLLKEITKF
SNE*AVPPTSVLPDRRASMFTLFKLGGKI*TFL
SS*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFP
FPKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSY
KAHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQ
DPCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQ
AREALPCAAQGLCAPHEHISLWPGGLQAGCGNS
S*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLY
VSGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*I
PFLETYCRFCALTTSPYVRFVKSVL*LNTETQ*
THTK*FHE*FFRCPSQLVS*SRILGVGVAEKSS
LKFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGH
ITYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFF
STFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIV
YLFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVV
GGDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFL
GFAALMMKCVFDASEKLSLAGYKILLQEIPSNL
LFVPKQLAYHASKFC*LQALSLGKQKNQSIISRW
ERFFY*KFIPDNSAFRKEIKCATSRGAALQLFR
ARARQDK*MGGTGGSCLRTTSGH*PLVDNCE*L
GFPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPI
RSLHLVSLLLQVDALLLILHLLQGRLGPHWTGC
QDVKAYGSFKETSWWFHAGGSAIPADLAWCLCV
STHVHVGWGKRVYR*R*ISWGLL*TALCVRSILK
LPVK*LDYFYLGISDYRSSLMFYVQIL*PLVTV
SELIRYPLINSTDLAVY*SITNLFSRTQRM*HL
YCSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF
*TIFYVNFIKIKLSTSF
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
*LGLETAPSPSFHEAG*TCRYAPRDMDRPRVAA
YWRRV*RLLCKEGIFE*LPSSRRPPTNGYLTTV
TLHCPPGVENALTGSLRSRDTMQTFCLFKPTRPS
TAVSWCHYYAASGSLVEGAGDVSEDTELDGTTF
LFITTQQNF*WKFVVNVKEGAFFAF*YTNHGFL
EQDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQF
VNNFCIKILRTYGLFSEDYVTPAVETEPANLKS
CLSLFLEITEFLNRETCDILPPFPTIASLTFLN
YF*YQKSSFEMELIKRAEGLLPACIDIPVPFVNI
YVPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGL
RCIDLVQCIFMIK*N*VRTRVNICLYLAQFERS
VINWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT
*VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATV
SITAESSCSIQLTPSWELAQAWGRASDGHLLGL
LHFSPTHSPLASLL*IHFETGLIPLPPAP*KNNS
GQKSVFFHFSRTVGYCQATCDPSHVVRVLFLCA
CSL*VQWKEATHWSVISEAADAQGDPRKSQVRE
Q*K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNF
QMSKQCHQLVFCPIEEPACSRYLN*VEKSKHFY
LHNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNF
LSPRISLGL*LIFKAVLELILFPDVSRAHW*GHT
KPTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPR
IPVLTCQSPD*STLLCFLSPAAPGSTHWVQPWA
RHGRPCPVLPRGCVHHMSTFPSGLAASRLAVETV
PEEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCM
YLVIKMPLCRKYASRGYTFLPFLKNIFVEKIIK
SPFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNK
HTQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV
*NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*V
ILLIN*AKCLCAIVFPLPCKILYSINK*KNHCFS
QLFQNQGL*IL*ILFLCDVSYCFIML*LVEILY
IYFLLI*CLNF*KVLTSLSPTPLPSHEVNS*EL
SGVTGELIADHVVLQGGSPPSGPGISSQVGFNSW
ALPPL**SVCLMPVRNSVWQATKFYSKKYPATF
CLFQSN*LIMQANFADSRLYL*ENKKTKVLSAG
GKDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSG
LGPGRTSEWVGQVAPA*GPPQATNPLWTTVSSW
VFPHLLCNFLCFEVGLTCLQELINCTALPTPHP
YGHCIWSACFFRSMPSF*YSISFRGGWGPTGLGV
KM*KLMGALRRLHGGSMQVVLPSLLI*PGACVC
PLTYTWGGGNVSTDDAKSVGVYSKQHCV*EASS
SSQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLY
QNSSGTHL*IALIWLYTDPSLTCFLGPSVCSIC
IAVSLAYLCFALMNFDRVIATLLVQYCCK*LQI
FKQSFMLIL*K*NFQLV
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