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Sequence BCL2L11.jAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAA
CCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAG
TTTAACGCTTACTATGCAAGGAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGA
CGGAGCTGTGGAGGCTGAATCCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATC
TTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACC
AACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGAT
GGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACC
ATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACT
TTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCT
AACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGA
CCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCC
ATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTC
CAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGT
TCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTA
ATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAG
AGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATT
TGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATA
GAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTC
TTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTC
AGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAA
ATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCT
AAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTT
TAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTG
GTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCA
CCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGC
AGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGC
TGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCT
CTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAA
AAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACA
GAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGG
AGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAG
ATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAA
TCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTA
GAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACT
CCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGG
TTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATAC
CCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTAT
TATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTG
CAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACT
GTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCA
CGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCAC
TGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGT
GCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAG
AAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCA
CTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTA
TGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAAT
AACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Mutually exclusive exon skipping
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFN
HYLSAMASMRQAEPADMRPEIWIAQELRRIGDE
FNAYYARRLEK*RKLSCSCHVFSPLKGSGEAFE
TELWRLNP*RRR*ERHRYF*IITKQPKTTHEWLS
YDCYVTLSAWCGECIDRFFAEPRYHADILLVQT
NKTQHRGLLVPLLCSQRFSCGGGR*RFRRHRAG
WDYLSVHHHTAEFLMEVCCECKGGSILCFLIYKP
WFFGAGFCVRMVFTCSVFSPSPSIRFFKKEMET
F*PICE*LLY*NFKNLRPILRGLCNPCSGN*AS
*LKKLP*FIFRDYRIFKQGDV*YTPSLPYYCLSD
LFKLFLIPKEFF*NGTD*KGRGSVASLH*YTSP
ICKYLRTFINSVASVAKFQTIFASFLITFCDAT
PVWTQMHRFGPVYFHDKVKLSQNKS*YLPVSCTV
RAICY*LGSIWCWFSFHFDEHVIGKYSEEAIAV
ITTDLSATPLCAAGFSGCRLSHGHRMHCQHQVP
EGHRVHYSRVQLQHPAHALMGIGTGLGQGF*WPF
AWPPAF*SNSQSTSFTPLNSL*NRPHPTSTSTI
EE*FWAEVCFFSFFQDSWILSGHL*PQPCSEGA
LSLCLLLMSAVEGSHTLVSHFRGSRCPGRPKKES
G*GAVKVRREDNSVNSVTLKIFENSIVKQLLKE
ITKFSNE*AVPPTSVLPDRRASMFTLFKLGGKI
*TFLSS*FKKYICIYCIFTFSFR*R*FQSKYSYF
KKFPFPKNLLGTLTYF*SCVGAHLVP*CVSSPL
VGSYKAHGYKQW*DCSRGPAGHTHTPKMYLDLG
TPSQDPCTHVPVS*LEHFTLFPQPCSPWEHTLGA
ALGQAREALPCAAQGLCAPHEHISLWPGGLQAG
CGNSS*GN*RFYEL*EY*RPGCWHQNLKR*LDV
SVLYVSGYQDASVQKVCLPWVYVFTFFKKHFCRK
NN*IPFLETYCRFCALTTSPYVRFVKSVL*LNT
ETQ*THTK*FHE*FFRCPSQLVS*SRILGVGVA
EKSSLKFLLIKKI*WNTIVCRFPFLMYIL*VFIR
FVGHITYQLSQMSVCNCVSFTL*NFVQHK*VKK
SLFFSTFSKSRIVNIVDSFSV*CVLLFHNAVTC
RNIVYLFSAYLMS*FLKSINIPVSHSPAVP*S*L
LRVVGGDWRAHCRPRGPPGWLSTFGSWYFQSSG
FQFLGFAALMMKCVFDASEKLSLAGYKILLQEI
PSNLLFVPKQLAYHASKFC*LQALSLGKQKNQSI
ISRWERFFY*KFIPDNSAFRKEIKCATSRGAAL
QLFRARARQDK*MGGTGGSCLRTTSGH*PLVDN
CE*LGFPPPAVQLPVL*GWTNLSSGAN*LYSPPH
APPIRSLHLVSLLLQVDALLLILHLLQGRLGPH
WTGCQDVKAYGSFKETSWWFHAGGSAIPADLAW
CLCVSTHVHVGWGKRVYR*R*ISWGLL*TALCVR
SILKLPVK*LDYFYLGISDYRSSLMFYVQIL*P
LVTVSELIRYPLINSTDLAVY*SITNLFSRTQR
M*HLYCSFPGLLVFCTDEF*QGNCHFTCAILL*I
TADF*TIFYVNFIKIKLSTSF
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKTGAQHP*VVTNQHKPQVLLARPS
TTISVQWLP*GRLNLQICAQRYGSPKSCGVLETS
LTLTMQGG*RNRGSCRVVVMYSVHLRAVGKRLR
RSCGG*ILEGGGERGTGIFE*LPSSRRPPTNGY
LTTVTLHCPPGVENALTGSLRSRDTMQTFCLFKP
TRPSTAVSWCHYYAASGSLVEGAGDVSEDTELD
GTTFLFITTQQNF*WKFVVNVKEGAFFAF*YTN
HGFLEQDFV*EWCLHAVCFPPHLQ*GFSKRKWKL
FNQFVNNFCIKILRTYGLFSEDYVTPAVETEPA
NLKSCLSLFLEITEFLNRETCDILPPFPTIASL
TFLNYF*YQKSSFEMELIKRAEGLLPACIDIPVP
FVNIYVPL*IQLHLWQNFRLFLRLSSSLFVMQL
QSGLRCIDLVQCIFMIK*N*VRTRVNICLYLAQ
FERSVINWEAFGVGFHSISTSMLLGSILKRQ*Q*
*QQT*VLRPFVLLAFLVAGFPMVTGCTVSIRSQ
RATVSITAESSCSIQLTPSWELAQAWGRASDGH
LLGLLHFSPTHSPLASLL*IHFETGLIPLPPAP*
KNNSGQKSVFFHFSRTVGYCQATCDPSHVVRVL
FLCACSL*VQWKEATHWSVISEAADAQGDPRKS
QVREQ*K*GGKTIL*TL*LLKFLKTPSLNNF*KK
*LNFQMSKQCHQLVFCPIEEPACSRYLN*VEKS
KHFYLHNLKNIYVYIAYSLFPLGRDDFNPNTLT
LKNFLSPRISLGL*LIFKAVLELILFPDVSRAHW
*GHTKPTVTSSGRIAAVGLLDTHIHQRCIWIWA
PPPRIPVLTCQSPD*STLLCFLSPAAPGSTHWV
QPWARHGRPCPVLPRGCVHHMSTFPSGLAASRLA
VETVPEEIRDSMNCRSIKDQAVGTRT*SDDWMS
LYCMYLVIKMPLCRKYASRGYTFLPFLKNIFVE
KIIKSPFWKLTAGFVP*QPLPM*GL*KVSCDLTQ
KRNKHTQNSFMSDSSDALPNWLVDQEFWGWGLR
RNQV*NSF*LKKYSGIQLSAVSPS*CIYCEYLL
DS*VILLIN*AKCLCAIVFPLPCKILYSINK*KN
HCFSQLFQNQGL*IL*ILFLCDVSYCFIML*LV
EILYIYFLLI*CLNF*KVLTSLSPTPLPSHEVN
S*ELSGVTGELIADHVVLQGGSPPSGPGISSQVG
FNSWALPPL**SVCLMPVRNSVWQATKFYSKKY
PATFCLFQSN*LIMQANFADSRLYL*ENKKTKV
LSAGGKDFSIENLSLTTQRLEKK*NVPLPEVLHC
SCSGLGPGRTSEWVGQVAPA*GPPQATNPLWTT
VSSWVFPHLLCNFLCFEVGLTCLQELINCTALP
TPHPYGHCIWSACFFRSMPSF*YSISFRGGWGPT
GLGVKM*KLMGALRRLHGGSMQVVLPSLLI*PG
ACVCPLTYTWGGGNVSTDDAKSVGVYSKQHCV*
EASSSSQLSNLTTFIWEFQTIEALLCFMSRFCDH
*LLYQNSSGTHL*IALIWLYTDPSLTCFLGPSV
CSICIAVSLAYLCFALMNFDRVIATLLVQYCCK
*LQIFKQSFMLIL*K*NFQLV
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATRQEPSTHEL*QINTNPKSSLPGLQ
PLSQCNGFHEAG*TCRYAPRDMDRPRVAAYWRR
V*RLLCKEVREIEEVVV*LSCIQST*GQWGSV*D
GAVEAESLKEEVREAQVFLNNYQAAEDHPRMVI
LRLLRYIVRLVWRMH*QVLCGAEIPCRHFACSN
QQDPAPRSPGAIIMQPAVLLWRGQVTFQKTPSWM
GLPFCSSPHSRISNGSLL*M*RREHSLLFNIQT
MVFWSRILCKNGVYMQCVFPLTFNKVFQKGNGN
FLTNL*ITFVLKF*EPTAYSQRIM*PLQWKLSQL
T*KAALVYF*RLQNF*TGRRVIYSLPSLLLPL*
PF*IIFNTKRVLLKWN*LKGQRVCCQPALIYQS
HL*IFTYLYKFSCICGKISDYFCVFPHHFL*CNS
SLDSDA*IWSSVFS**SEIESEQELISACILHS
SSDLLLTGKHLVLVFIPFRRACYWEVF*RGNSS
NNNRLKCYAPLCCWLFWLQAFPWSQDALSASGPR
GPPCPLQQSPAAASSSRPHGNWHRPGAGLLMAI
CLASCILVQLTVH*LHSFKFTLKQASSHFHQHH
RRIILGRSLFFFIFPGQLDIVRPLVTPAM**GCS
FSVPAPYECSGRKPHTGQSFQRQQMPRETQERV
RLGSSESEEGRQFCELCNS*NF*KLHR*TTFKR
NN*IFK*VSSATN*CFAR*KSQHVHVI*IRWKNL
NIFIFII*KIYMYILHIHFFL*VEMISIQILLL
*KISFPQESPWDFDLFLKLCWSSSCSLMCLEPI
GRVIQSPRLQAVVGLQPWACWTHTYTKDVFGSGH
PLPGSLYSRASLLTRALYSVSSALQPLGAHTGC
SPGPGTGGPALCCPGAVCTT*AHFPLAWRPPGW
LWKQFLRKLEIL*IVGVLKTRLLAPELKAMTGCL
CTVCIWLSRCLCAESMPPVGIRFYLF*KTFL*K
K*LNPLFGNLLQVLCLDNLSLCEVCKKCPVT*H
RNAINTHKIVS*VILQMPFPTG*LIKNFGGGGCG
EIKFKIPSD*KNIVEYNCLPFPLLNVYIVSIY*
IRRSYYLSTEPNVCVQLCFLYLVKFCTA*ISKK
ITVFLNFFKIKDCKYCRFFFCVMCPTVS*CCNL*
KYCIFIFCLFNVLISEKY*HPCLPLPCRPMKLT
PESCRG*LESSLQTTWSSRVALHLRVLVFPVKW
VSILGLCRPYDEVCV*CQ*ETQSGRLQNSTPRNT
QQPSVCSKATSLSCKQILLTPGFIFRKTKKPKY
YQQVGKIFLLKIYP*QLSV*KRNKMCHFQRCCI
AVVQG*GQAGQVNGWDRWLLPKDHLRPLTPCGQL
*VAGFSPTCCATSCALRLD*LVFRS*LTVQPSP
RPTHTVTAFGQPASSGRCPPSDTPSPSGEVGAP
LDWVSRCESLWEL*GDFMVVPCRWFCHPC*FSLV
PVCVHSRTRGVGETCLQMTLNQLGSTLNSIVCK
KHPQAPS*VT*LLLFGNFRL*KLSYVLCPDSVT
TSYCIRTHQVPTYK*H*SGCILIHH*PVF*DPAY
VAFVLQFPWLTCVLH**ILTG*LPLYLCNTAVN
NCRFLNNLLC*FYKNKTFN*F
Sequence BCL2L11.dAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAA
CCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAG
TTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCC
GCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCC
TGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCA
CACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGT
GTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTT
TGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTAT
TTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCA
AAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTA
TAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATT
TGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGA
AGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGC
CCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAG
AGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCC
AACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCT
GTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAG
TGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGG
AGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAG
CAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAA
AAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAAT
CTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTT
ACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCA
CGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCC
CTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATT
AGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCA
AGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAA
ACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAAT
AGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCT
GATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAA
CTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAA
AATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGC
TTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGG
AGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCC
TTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAA
GCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTC
TATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGC
AGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACC
TGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCAT
TTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAG
CTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACA
CGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAG
TAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCA
GGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCC
TGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTT
TATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Mutually exclusive exon skipping
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFN
HYLSAMASMRQAEPADMRPEIWIAQELRRIGDE
FNAYYARRVFLNNYQAAEDHPRMVILRLLRYIV
RLVWRMH*QVLCGAEIPCRHFACSNQQDPAPRSP
GAIIMQPAVLLWRGQVTFQKTPSWMGLPFCSSP
HSRISNGSLL*M*RREHSLLFNIQTMVFWSRIL
CKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*ITF
VLKF*EPTAYSQRIM*PLQWKLSQLT*KAALVY
F*RLQNF*TGRRVIYSLPSLLLPL*PF*IIFNT
KRVLLKWN*LKGQRVCCQPALIYQSHL*IFTYLY
KFSCICGKISDYFCVFPHHFL*CNSSLDSDA*I
WSSVFS**SEIESEQELISACILHSSSDLLLTG
KHLVLVFIPFRRACYWEVF*RGNSSNNNRLKCYA
PLCCWLFWLQAFPWSQDALSASGPRGPPCPLQQ
SPAAASSSRPHGNWHRPGAGLLMAICLASCILV
QLTVH*LHSFKFTLKQASSHFHQHHRRIILGRSL
FFFIFPGQLDIVRPLVTPAM**GCSFSVPAPYE
CSGRKPHTGQSFQRQQMPRETQERVRLGSSESE
EGRQFCELCNS*NF*KLHR*TTFKRNN*IFK*VS
SATN*CFAR*KSQHVHVI*IRWKNLNIFIFII*
KIYMYILHIHFFL*VEMISIQILLL*KISFPQE
SPWDFDLFLKLCWSSSCSLMCLEPIGRVIQSPRL
QAVVGLQPWACWTHTYTKDVFGSGHPLPGSLYS
RASLLTRALYSVSSALQPLGAHTGCSPGPGTGG
PALCCPGAVCTT*AHFPLAWRPPGWLWKQFLRKL
EIL*IVGVLKTRLLAPELKAMTGCLCTVCIWLS
RCLCAESMPPVGIRFYLF*KTFL*KK*LNPLFG
NLLQVLCLDNLSLCEVCKKCPVT*HRNAINTHKI
VS*VILQMPFPTG*LIKNFGGGGCGEIKFKIPS
D*KNIVEYNCLPFPLLNVYIVSIY*IRRSYYLS
TEPNVCVQLCFLYLVKFCTA*ISKKITVFLNFFK
IKDCKYCRFFFCVMCPTVS*CCNL*KYCIFIFC
LFNVLISEKY*HPCLPLPCRPMKLTPESCRG*L
ESSLQTTWSSRVALHLRVLVFPVKWVSILGLCRP
YDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVCSK
ATSLSCKQILLTPGFIFRKTKKPKYYQQVGKIF
LLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*GQA
GQVNGWDRWLLPKDHLRPLTPCGQL*VAGFSPT
CCATSCALRLD*LVFRS*LTVQPSPRPTHTVTA
FGQPASSGRCPPSDTPSPSGEVGAPLDWVSRCES
LWEL*GDFMVVPCRWFCHPC*FSLVPVCVHSRT
RGVGETCLQMTLNQLGSTLNSIVCKKHPQAPS*
VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIRTHQ
VPTYK*H*SGCILIHH*PVF*DPAYVAFVLQFP
WLTCVLH**ILTG*LPLYLCNTAVNNCRFLNNL
LC*FYKNKTFN*F
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKTGAQHP*VVTNQHKPQVLLARPS
TTISVQWLP*GRLNLQICAQRYGSPKSCGVLETS
LTLTMQGGYF*IITKQPKTTHEWLSYDCYVTLS
AWCGECIDRFFAEPRYHADILLVQTNKTQHRGL
LVPLLCSQRFSCGGGR*RFRRHRAGWDYLSVHHH
TAEFLMEVCCECKGGSILCFLIYKPWFFGAGFC
VRMVFTCSVFSPSPSIRFFKKEMETF*PICE*L
LY*NFKNLRPILRGLCNPCSGN*AS*LKKLP*FI
FRDYRIFKQGDV*YTPSLPYYCLSDLFKLFLIP
KEFF*NGTD*KGRGSVASLH*YTSPICKYLRTF
INSVASVAKFQTIFASFLITFCDATPVWTQMHRF
GPVYFHDKVKLSQNKS*YLPVSCTVRAICY*LG
SIWCWFSFHFDEHVIGKYSEEAIAVITTDLSAT
PLCAAGFSGCRLSHGHRMHCQHQVPEGHRVHYSR
VQLQHPAHALMGIGTGLGQGF*WPFAWPPAF*S
NSQSTSFTPLNSL*NRPHPTSTSTIEE*FWAEV
CFFSFFQDSWILSGHL*PQPCSEGALSLCLLLMS
AVEGSHTLVSHFRGSRCPGRPKKESG*GAVKVR
REDNSVNSVTLKIFENSIVKQLLKEITKFSNE*
AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS*FK
KYICIYCIFTFSFR*R*FQSKYSYFKKFPFPKN
LLGTLTYF*SCVGAHLVP*CVSSPLVGSYKAHG
YKQW*DCSRGPAGHTHTPKMYLDLGTPSQDPCTH
VPVS*LEHFTLFPQPCSPWEHTLGAALGQAREA
LPCAAQGLCAPHEHISLWPGGLQAGCGNSS*GN
*RFYEL*EY*RPGCWHQNLKR*LDVSVLYVSGYQ
DASVQKVCLPWVYVFTFFKKHFCRKNN*IPFLE
TYCRFCALTTSPYVRFVKSVL*LNTETQ*THTK
*FHE*FFRCPSQLVS*SRILGVGVAEKSSLKFLL
IKKI*WNTIVCRFPFLMYIL*VFIRFVGHITYQ
LSQMSVCNCVSFTL*NFVQHK*VKKSLFFSTFS
KSRIVNIVDSFSV*CVLLFHNAVTCRNIVYLFSA
YLMS*FLKSINIPVSHSPAVP*S*LLRVVGGDW
RAHCRPRGPPGWLSTFGSWYFQSSGFQFLGFAA
LMMKCVFDASEKLSLAGYKILLQEIPSNLLFVPK
QLAYHASKFC*LQALSLGKQKNQSIISRWERFF
Y*KFIPDNSAFRKEIKCATSRGAALQLFRARAR
QDK*MGGTGGSCLRTTSGH*PLVDNCE*LGFPPP
AVQLPVL*GWTNLSSGAN*LYSPPHAPPIRSLH
LVSLLLQVDALLLILHLLQGRLGPHWTGCQDVK
AYGSFKETSWWFHAGGSAIPADLAWCLCVSTHVH
VGWGKRVYR*R*ISWGLL*TALCVRSILKLPVK
*LDYFYLGISDYRSSLMFYVQIL*PLVTVSELI
RYPLINSTDLAVY*SITNLFSRTQRM*HLYCSFP
GLLVFCTDEF*QGNCHFTCAILL*ITADF*TIF
YVNFIKIKLSTSF
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATRQEPSTHEL*QINTNPKSSLPGLQ
PLSQCNGFHEAG*TCRYAPRDMDRPRVAAYWRR
V*RLLCKEGIFE*LPSSRRPPTNGYLTTVTLHCP
PGVENALTGSLRSRDTMQTFCLFKPTRPSTAVS
WCHYYAASGSLVEGAGDVSEDTELDGTTFLFIT
TQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQDFV
*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVNNF
CIKILRTYGLFSEDYVTPAVETEPANLKSCLSL
FLEITEFLNRETCDILPPFPTIASLTFLNYF*YQ
KSSFEMELIKRAEGLLPACIDIPVPFVNIYVPL
*IQLHLWQNFRLFLRLSSSLFVMQLQSGLRCID
LVQCIFMIK*N*VRTRVNICLYLAQFERSVINWE
AFGVGFHSISTSMLLGSILKRQ*Q**QQT*VLR
PFVLLAFLVAGFPMVTGCTVSIRSQRATVSITA
ESSCSIQLTPSWELAQAWGRASDGHLLGLLHFSP
THSPLASLL*IHFETGLIPLPPAP*KNNSGQKS
VFFHFSRTVGYCQATCDPSHVVRVLFLCACSL*
VQWKEATHWSVISEAADAQGDPRKSQVREQ*K*G
GKTIL*TL*LLKFLKTPSLNNF*KK*LNFQMSK
QCHQLVFCPIEEPACSRYLN*VEKSKHFYLHNL
KNIYVYIAYSLFPLGRDDFNPNTLTLKNFLSPRI
SLGL*LIFKAVLELILFPDVSRAHW*GHTKPTV
TSSGRIAAVGLLDTHIHQRCIWIWAPPPRIPVL
TCQSPD*STLLCFLSPAAPGSTHWVQPWARHGRP
CPVLPRGCVHHMSTFPSGLAASRLAVETVPEEI
RDSMNCRSIKDQAVGTRT*SDDWMSLYCMYLVI
KMPLCRKYASRGYTFLPFLKNIFVEKIIKSPFWK
LTAGFVP*QPLPM*GL*KVSCDLTQKRNKHTQN
SFMSDSSDALPNWLVDQEFWGWGLRRNQV*NSF
*LKKYSGIQLSAVSPS*CIYCEYLLDS*VILLIN
*AKCLCAIVFPLPCKILYSINK*KNHCFSQLFQ
NQGL*IL*ILFLCDVSYCFIML*LVEILYIYFL
LI*CLNF*KVLTSLSPTPLPSHEVNS*ELSGVTG
ELIADHVVLQGGSPPSGPGISSQVGFNSWALPP
L**SVCLMPVRNSVWQATKFYSKKYPATFCLFQ
SN*LIMQANFADSRLYL*ENKKTKVLSAGGKDFS
IENLSLTTQRLEKK*NVPLPEVLHCSCSGLGPG
RTSEWVGQVAPA*GPPQATNPLWTTVSSWVFPH
LLCNFLCFEVGLTCLQELINCTALPTPHPYGHCI
WSACFFRSMPSF*YSISFRGGWGPTGLGVKM*K
LMGALRRLHGGSMQVVLPSLLI*PGACVCPLTY
TWGGGNVSTDDAKSVGVYSKQHCV*EASSSSQLS
NLTTFIWEFQTIEALLCFMSRFCDH*LLYQNSS
GTHL*IALIWLYTDPSLTCFLGPSVCSICIAVS
LAYLCFALMNFDRVIATLLVQYCCK*LQIFKQSF
MLIL*K*NFQLV
Sequence BCL2L11.iAug05
GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGTCTCACTCTGTCACCCAGGCTGGAGTGCACTGGTGCGATCTTGGCTCACTGCAACCTCCAACTCCCAAGT
TCAAGCGGTTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCC
AAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTAT
CTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAAC
CAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGA
TGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAAC
CATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAAC
TTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGC
TAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTG
ACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCC
CATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACT
CCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAG
TTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGT
AATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCA
GAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCAT
TTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCAT
AGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCT
CTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGT
CAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGA
AATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATC
TAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACT
TTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATT
GGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGC
ACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTG
CAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGG
CTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTC
TCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAA
AAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACAC
AGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCG
GAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTA
GATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAA
ATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGT
AGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAAC
TCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGG
GTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATA
CCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTA
TTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATT
GCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAAC
TGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCC
ACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCA
CTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGG
TGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAA
GAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACC
ACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGT
ATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAA
TAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
- 113317 (forward primer)
- BCL2L11-4 (reverse primer)
- Mutually exclusive exon skipping
Frame 0
DQMAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQVSLCHPGWSALVRSWLTATSNSQV
QAVLLPQPPK*LGLQLP*GRLNLQICAQRYGSP
KSCGVLETSLTLTMQGGYF*IITKQPKTTHEWL
SYDCYVTLSAWCGECIDRFFAEPRYHADILLVQT
NKTQHRGLLVPLLCSQRFSCGGGR*RFRRHRAG
WDYLSVHHHTAEFLMEVCCECKGGSILCFLIYK
PWFFGAGFCVRMVFTCSVFSPSPSIRFFKKEMET
F*PICE*LLY*NFKNLRPILRGLCNPCSGN*AS
*LKKLP*FIFRDYRIFKQGDV*YTPSLPYYCLS
DLFKLFLIPKEFF*NGTD*KGRGSVASLH*YTSP
ICKYLRTFINSVASVAKFQTIFASFLITFCDAT
PVWTQMHRFGPVYFHDKVKLSQNKS*YLPVSCT
VRAICY*LGSIWCWFSFHFDEHVIGKYSEEAIAV
ITTDLSATPLCAAGFSGCRLSHGHRMHCQHQVP
EGHRVHYSRVQLQHPAHALMGIGTGLGQGF*WP
FAWPPAF*SNSQSTSFTPLNSL*NRPHPTSTSTI
EE*FWAEVCFFSFFQDSWILSGHL*PQPCSEGA
LSLCLLLMSAVEGSHTLVSHFRGSRCPGRPKKE
SG*GAVKVRREDNSVNSVTLKIFENSIVKQLLKE
ITKFSNE*AVPPTSVLPDRRASMFTLFKLGGKI
*TFLSS*FKKYICIYCIFTFSFR*R*FQSKYSY
FKKFPFPKNLLGTLTYF*SCVGAHLVP*CVSSPL
VGSYKAHGYKQW*DCSRGPAGHTHTPKMYLDLG
TPSQDPCTHVPVS*LEHFTLFPQPCSPWEHTLG
AALGQAREALPCAAQGLCAPHEHISLWPGGLQAG
CGNSS*GN*RFYEL*EY*RPGCWHQNLKR*LDV
SVLYVSGYQDASVQKVCLPWVYVFTFFKKHFCR
KNN*IPFLETYCRFCALTTSPYVRFVKSVL*LNT
ETQ*THTK*FHE*FFRCPSQLVS*SRILGVGVA
EKSSLKFLLIKKI*WNTIVCRFPFLMYIL*VFI
RFVGHITYQLSQMSVCNCVSFTL*NFVQHK*VKK
SLFFSTFSKSRIVNIVDSFSV*CVLLFHNAVTC
RNIVYLFSAYLMS*FLKSINIPVSHSPAVP*S*
LLRVVGGDWRAHCRPRGPPGWLSTFGSWYFQSSG
FQFLGFAALMMKCVFDASEKLSLAGYKILLQEI
PSNLLFVPKQLAYHASKFC*LQALSLGKQKNQS
IISRWERFFY*KFIPDNSAFRKEIKCATSRGAAL
QLFRARARQDK*MGGTGGSCLRTTSGH*PLVDN
CE*LGFPPPAVQLPVL*GWTNLSSGAN*LYSPP
HAPPIRSLHLVSLLLQVDALLLILHLLQGRLGPH
WTGCQDVKAYGSFKETSWWFHAGGSAIPADLAW
CLCVSTHVHVGWGKRVYR*R*ISWGLL*TALCV
RSILKLPVK*LDYFYLGISDYRSSLMFYVQIL*P
LVTVSELIRYPLINSTDLAVY*SITNLFSRTQR
M*HLYCSFPGLLVFCTDEF*QGNCHFTCAILL*
ITADF*TIFYVNFIKIKLSTSF
Frame 1
TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKSHSVTQAGVHWCDLGSLQPPTPK
FKRFSCLSLPSSWDYSFHEAG*TCRYAPRDMDRP
RVAAYWRRV*RLLCKEGIFE*LPSSRRPPTNGY
LTTVTLHCPPGVENALTGSLRSRDTMQTFCLFK
PTRPSTAVSWCHYYAASGSLVEGAGDVSEDTELD
GTTFLFITTQQNF*WKFVVNVKEGAFFAF*YTN
HGFLEQDFV*EWCLHAVCFPPHLQ*GFSKRKWK
LFNQFVNNFCIKILRTYGLFSEDYVTPAVETEPA
NLKSCLSLFLEITEFLNRETCDILPPFPTIASL
TFLNYF*YQKSSFEMELIKRAEGLLPACIDIPV
PFVNIYVPL*IQLHLWQNFRLFLRLSSSLFVMQL
QSGLRCIDLVQCIFMIK*N*VRTRVNICLYLAQ
FERSVINWEAFGVGFHSISTSMLLGSILKRQ*Q
**QQT*VLRPFVLLAFLVAGFPMVTGCTVSIRSQ
RATVSITAESSCSIQLTPSWELAQAWGRASDGH
LLGLLHFSPTHSPLASLL*IHFETGLIPLPPAP
*KNNSGQKSVFFHFSRTVGYCQATCDPSHVVRVL
FLCACSL*VQWKEATHWSVISEAADAQGDPRKS
QVREQ*K*GGKTIL*TL*LLKFLKTPSLNNF*K
K*LNFQMSKQCHQLVFCPIEEPACSRYLN*VEKS
KHFYLHNLKNIYVYIAYSLFPLGRDDFNPNTLT
LKNFLSPRISLGL*LIFKAVLELILFPDVSRAH
W*GHTKPTVTSSGRIAAVGLLDTHIHQRCIWIWA
PPPRIPVLTCQSPD*STLLCFLSPAAPGSTHWV
QPWARHGRPCPVLPRGCVHHMSTFPSGLAASRL
AVETVPEEIRDSMNCRSIKDQAVGTRT*SDDWMS
LYCMYLVIKMPLCRKYASRGYTFLPFLKNIFVE
KIIKSPFWKLTAGFVP*QPLPM*GL*KVSCDLT
QKRNKHTQNSFMSDSSDALPNWLVDQEFWGWGLR
RNQV*NSF*LKKYSGIQLSAVSPS*CIYCEYLL
DS*VILLIN*AKCLCAIVFPLPCKILYSINK*K
NHCFSQLFQNQGL*IL*ILFLCDVSYCFIML*LV
EILYIYFLLI*CLNF*KVLTSLSPTPLPSHEVN
S*ELSGVTGELIADHVVLQGGSPPSGPGISSQV
GFNSWALPPL**SVCLMPVRNSVWQATKFYSKKY
PATFCLFQSN*LIMQANFADSRLYL*ENKKTKV
LSAGGKDFSIENLSLTTQRLEKK*NVPLPEVLH
CSCSGLGPGRTSEWVGQVAPA*GPPQATNPLWTT
VSSWVFPHLLCNFLCFEVGLTCLQELINCTALP
TPHPYGHCIWSACFFRSMPSF*YSISFRGGWGP
TGLGVKM*KLMGALRRLHGGSMQVVLPSLLI*PG
ACVCPLTYTWGGGNVSTDDAKSVGVYSKQHCV*
EASSSSQLSNLTTFIWEFQTIEALLCFMSRFCD
H*LLYQNSSGTHL*IALIWLYTDPSLTCFLGPSV
CSICIAVSLAYLCFALMNFDRVIATLLVQYCCK
*LQIFKQSFMLIL*K*NFQLV
Frame 2
PNGKATF*CKF*V*PRR*TIAACGEASPAQTWGPYLPTDRATSLTLSPRLECTGAILAHCNLQLPS
SSGSPASASQVAGITASMRQAEPADMRPEIWIA
QELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVI
LRLLRYIVRLVWRMH*QVLCGAEIPCRHFACSN
QQDPAPRSPGAIIMQPAVLLWRGQVTFQKTPSW
MGLPFCSSPHSRISNGSLL*M*RREHSLLFNIQT
MVFWSRILCKNGVYMQCVFPLTFNKVFQKGNGN
FLTNL*ITFVLKF*EPTAYSQRIM*PLQWKLSQ
LT*KAALVYF*RLQNF*TGRRVIYSLPSLLLPL*
PF*IIFNTKRVLLKWN*LKGQRVCCQPALIYQS
HL*IFTYLYKFSCICGKISDYFCVFPHHFL*CN
SSLDSDA*IWSSVFS**SEIESEQELISACILHS
SSDLLLTGKHLVLVFIPFRRACYWEVF*RGNSS
NNNRLKCYAPLCCWLFWLQAFPWSQDALSASGP
RGPPCPLQQSPAAASSSRPHGNWHRPGAGLLMAI
CLASCILVQLTVH*LHSFKFTLKQASSHFHQHH
RRIILGRSLFFFIFPGQLDIVRPLVTPAM**GC
SFSVPAPYECSGRKPHTGQSFQRQQMPRETQERV
RLGSSESEEGRQFCELCNS*NF*KLHR*TTFKR
NN*IFK*VSSATN*CFAR*KSQHVHVI*IRWKN
LNIFIFII*KIYMYILHIHFFL*VEMISIQILLL
*KISFPQESPWDFDLFLKLCWSSSCSLMCLEPI
GRVIQSPRLQAVVGLQPWACWTHTYTKDVFGSG
HPLPGSLYSRASLLTRALYSVSSALQPLGAHTGC
SPGPGTGGPALCCPGAVCTT*AHFPLAWRPPGW
LWKQFLRKLEIL*IVGVLKTRLLAPELKAMTGC
LCTVCIWLSRCLCAESMPPVGIRFYLF*KTFL*K
K*LNPLFGNLLQVLCLDNLSLCEVCKKCPVT*H
RNAINTHKIVS*VILQMPFPTG*LIKNFGGGGC
GEIKFKIPSD*KNIVEYNCLPFPLLNVYIVSIY*
IRRSYYLSTEPNVCVQLCFLYLVKFCTA*ISKK
ITVFLNFFKIKDCKYCRFFFCVMCPTVS*CCNL
*KYCIFIFCLFNVLISEKY*HPCLPLPCRPMKLT
PESCRG*LESSLQTTWSSRVALHLRVLVFPVKW
VSILGLCRPYDEVCV*CQ*ETQSGRLQNSTPRN
TQQPSVCSKATSLSCKQILLTPGFIFRKTKKPKY
YQQVGKIFLLKIYP*QLSV*KRNKMCHFQRCCI
AVVQG*GQAGQVNGWDRWLLPKDHLRPLTPCGQ
L*VAGFSPTCCATSCALRLD*LVFRS*LTVQPSP
RPTHTVTAFGQPASSGRCPPSDTPSPSGEVGAP
LDWVSRCESLWEL*GDFMVVPCRWFCHPC*FSL
VPVCVHSRTRGVGETCLQMTLNQLGSTLNSIVCK
KHPQAPS*VT*LLLFGNFRL*KLSYVLCPDSVT
TSYCIRTHQVPTYK*H*SGCILIHH*PVF*DPA
YVAFVLQFPWLTCVLH**ILTG*LPLYLCNTAVN
NCRFLNNLLC*FYKNKTFN*F
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