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Sequences

Sequence BCL2L11.iAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGTCTCACTCTGTCACCCAGGCTGGAGTGCACTGGTGCGATCTTGGCTCACTGCAACCTCCAACTCCCAAGT
TCAAGCGGTTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCC
AAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTAT
CTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAAC
CAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGA
TGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAAC
CATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAAC
TTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGC
TAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTG
ACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCC
CATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACT
CCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAG
TTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGT
AATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCA
GAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCAT
TTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCAT
AGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCT
CTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGT
CAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGA
AATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATC
TAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACT
TTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATT
GGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGC
ACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTG
CAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGG
CTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTC
TCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAA
AAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACAC
AGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCG
GAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTA
GATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAA
ATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGT
AGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAAC
TCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGG
GTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATA
CCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTA
TTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATT
GCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAAC
TGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCC
ACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCA
CTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGG
TGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAA
GAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACC
ACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGT
ATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAA
TAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQVSLCHPGWSALVRSWLTATSNSQV
QAVLLPQPPK*LGLQLP*GRLNLQICAQRYGSP
KSCGVLETSLTLTMQGGYF*IITKQPKTTHEWL
SYDCYVTLSAWCGECIDRFFAEPRYHADILLVQT
NKTQHRGLLVPLLCSQRFSCGGGR*RFRRHRAG
WDYLSVHHHTAEFLMEVCCECKGGSILCFLIYK
PWFFGAGFCVRMVFTCSVFSPSPSIRFFKKEMET
F*PICE*LLY*NFKNLRPILRGLCNPCSGN*AS
*LKKLP*FIFRDYRIFKQGDV*YTPSLPYYCLS
DLFKLFLIPKEFF*NGTD*KGRGSVASLH*YTSP
ICKYLRTFINSVASVAKFQTIFASFLITFCDAT
PVWTQMHRFGPVYFHDKVKLSQNKS*YLPVSCT
VRAICY*LGSIWCWFSFHFDEHVIGKYSEEAIAV
ITTDLSATPLCAAGFSGCRLSHGHRMHCQHQVP
EGHRVHYSRVQLQHPAHALMGIGTGLGQGF*WP
FAWPPAF*SNSQSTSFTPLNSL*NRPHPTSTSTI
EE*FWAEVCFFSFFQDSWILSGHL*PQPCSEGA
LSLCLLLMSAVEGSHTLVSHFRGSRCPGRPKKE
SG*GAVKVRREDNSVNSVTLKIFENSIVKQLLKE
ITKFSNE*AVPPTSVLPDRRASMFTLFKLGGKI
*TFLSS*FKKYICIYCIFTFSFR*R*FQSKYSY
FKKFPFPKNLLGTLTYF*SCVGAHLVP*CVSSPL
VGSYKAHGYKQW*DCSRGPAGHTHTPKMYLDLG
TPSQDPCTHVPVS*LEHFTLFPQPCSPWEHTLG
AALGQAREALPCAAQGLCAPHEHISLWPGGLQAG
CGNSS*GN*RFYEL*EY*RPGCWHQNLKR*LDV
SVLYVSGYQDASVQKVCLPWVYVFTFFKKHFCR
KNN*IPFLETYCRFCALTTSPYVRFVKSVL*LNT
ETQ*THTK*FHE*FFRCPSQLVS*SRILGVGVA
EKSSLKFLLIKKI*WNTIVCRFPFLMYIL*VFI
RFVGHITYQLSQMSVCNCVSFTL*NFVQHK*VKK
SLFFSTFSKSRIVNIVDSFSV*CVLLFHNAVTC
RNIVYLFSAYLMS*FLKSINIPVSHSPAVP*S*
LLRVVGGDWRAHCRPRGPPGWLSTFGSWYFQSSG
FQFLGFAALMMKCVFDASEKLSLAGYKILLQEI
PSNLLFVPKQLAYHASKFC*LQALSLGKQKNQS
IISRWERFFY*KFIPDNSAFRKEIKCATSRGAAL
QLFRARARQDK*MGGTGGSCLRTTSGH*PLVDN
CE*LGFPPPAVQLPVL*GWTNLSSGAN*LYSPP
HAPPIRSLHLVSLLLQVDALLLILHLLQGRLGPH
WTGCQDVKAYGSFKETSWWFHAGGSAIPADLAW
CLCVSTHVHVGWGKRVYR*R*ISWGLL*TALCV
RSILKLPVK*LDYFYLGISDYRSSLMFYVQIL*P
LVTVSELIRYPLINSTDLAVY*SITNLFSRTQR
M*HLYCSFPGLLVFCTDEF*QGNCHFTCAILL*
ITADF*TIFYVNFIKIKLSTSF

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKSHSVTQAGVHWCDLGSLQPPTPK
FKRFSCLSLPSSWDYSFHEAG*TCRYAPRDMDRP
RVAAYWRRV*RLLCKEGIFE*LPSSRRPPTNGY
LTTVTLHCPPGVENALTGSLRSRDTMQTFCLFK
PTRPSTAVSWCHYYAASGSLVEGAGDVSEDTELD
GTTFLFITTQQNF*WKFVVNVKEGAFFAF*YTN
HGFLEQDFV*EWCLHAVCFPPHLQ*GFSKRKWK
LFNQFVNNFCIKILRTYGLFSEDYVTPAVETEPA
NLKSCLSLFLEITEFLNRETCDILPPFPTIASL
TFLNYF*YQKSSFEMELIKRAEGLLPACIDIPV
PFVNIYVPL*IQLHLWQNFRLFLRLSSSLFVMQL
QSGLRCIDLVQCIFMIK*N*VRTRVNICLYLAQ
FERSVINWEAFGVGFHSISTSMLLGSILKRQ*Q
**QQT*VLRPFVLLAFLVAGFPMVTGCTVSIRSQ
RATVSITAESSCSIQLTPSWELAQAWGRASDGH
LLGLLHFSPTHSPLASLL*IHFETGLIPLPPAP
*KNNSGQKSVFFHFSRTVGYCQATCDPSHVVRVL
FLCACSL*VQWKEATHWSVISEAADAQGDPRKS
QVREQ*K*GGKTIL*TL*LLKFLKTPSLNNF*K
K*LNFQMSKQCHQLVFCPIEEPACSRYLN*VEKS
KHFYLHNLKNIYVYIAYSLFPLGRDDFNPNTLT
LKNFLSPRISLGL*LIFKAVLELILFPDVSRAH
W*GHTKPTVTSSGRIAAVGLLDTHIHQRCIWIWA
PPPRIPVLTCQSPD*STLLCFLSPAAPGSTHWV
QPWARHGRPCPVLPRGCVHHMSTFPSGLAASRL
AVETVPEEIRDSMNCRSIKDQAVGTRT*SDDWMS
LYCMYLVIKMPLCRKYASRGYTFLPFLKNIFVE
KIIKSPFWKLTAGFVP*QPLPM*GL*KVSCDLT
QKRNKHTQNSFMSDSSDALPNWLVDQEFWGWGLR
RNQV*NSF*LKKYSGIQLSAVSPS*CIYCEYLL
DS*VILLIN*AKCLCAIVFPLPCKILYSINK*K
NHCFSQLFQNQGL*IL*ILFLCDVSYCFIML*LV
EILYIYFLLI*CLNF*KVLTSLSPTPLPSHEVN
S*ELSGVTGELIADHVVLQGGSPPSGPGISSQV
GFNSWALPPL**SVCLMPVRNSVWQATKFYSKKY
PATFCLFQSN*LIMQANFADSRLYL*ENKKTKV
LSAGGKDFSIENLSLTTQRLEKK*NVPLPEVLH
CSCSGLGPGRTSEWVGQVAPA*GPPQATNPLWTT
VSSWVFPHLLCNFLCFEVGLTCLQELINCTALP
TPHPYGHCIWSACFFRSMPSF*YSISFRGGWGP
TGLGVKM*KLMGALRRLHGGSMQVVLPSLLI*PG
ACVCPLTYTWGGGNVSTDDAKSVGVYSKQHCV*
EASSSSQLSNLTTFIWEFQTIEALLCFMSRFCD
H*LLYQNSSGTHL*IALIWLYTDPSLTCFLGPSV
CSICIAVSLAYLCFALMNFDRVIATLLVQYCCK
*LQIFKQSFMLIL*K*NFQLV

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATSLTLSPRLECTGAILAHCNLQLPS
SSGSPASASQVAGITASMRQAEPADMRPEIWIA
QELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVI
LRLLRYIVRLVWRMH*QVLCGAEIPCRHFACSN
QQDPAPRSPGAIIMQPAVLLWRGQVTFQKTPSW
MGLPFCSSPHSRISNGSLL*M*RREHSLLFNIQT
MVFWSRILCKNGVYMQCVFPLTFNKVFQKGNGN
FLTNL*ITFVLKF*EPTAYSQRIM*PLQWKLSQ
LT*KAALVYF*RLQNF*TGRRVIYSLPSLLLPL*
PF*IIFNTKRVLLKWN*LKGQRVCCQPALIYQS
HL*IFTYLYKFSCICGKISDYFCVFPHHFL*CN
SSLDSDA*IWSSVFS**SEIESEQELISACILHS
SSDLLLTGKHLVLVFIPFRRACYWEVF*RGNSS
NNNRLKCYAPLCCWLFWLQAFPWSQDALSASGP
RGPPCPLQQSPAAASSSRPHGNWHRPGAGLLMAI
CLASCILVQLTVH*LHSFKFTLKQASSHFHQHH
RRIILGRSLFFFIFPGQLDIVRPLVTPAM**GC
SFSVPAPYECSGRKPHTGQSFQRQQMPRETQERV
RLGSSESEEGRQFCELCNS*NF*KLHR*TTFKR
NN*IFK*VSSATN*CFAR*KSQHVHVI*IRWKN
LNIFIFII*KIYMYILHIHFFL*VEMISIQILLL
*KISFPQESPWDFDLFLKLCWSSSCSLMCLEPI
GRVIQSPRLQAVVGLQPWACWTHTYTKDVFGSG
HPLPGSLYSRASLLTRALYSVSSALQPLGAHTGC
SPGPGTGGPALCCPGAVCTT*AHFPLAWRPPGW
LWKQFLRKLEIL*IVGVLKTRLLAPELKAMTGC
LCTVCIWLSRCLCAESMPPVGIRFYLF*KTFL*K
K*LNPLFGNLLQVLCLDNLSLCEVCKKCPVT*H
RNAINTHKIVS*VILQMPFPTG*LIKNFGGGGC
GEIKFKIPSD*KNIVEYNCLPFPLLNVYIVSIY*
IRRSYYLSTEPNVCVQLCFLYLVKFCTA*ISKK
ITVFLNFFKIKDCKYCRFFFCVMCPTVS*CCNL
*KYCIFIFCLFNVLISEKY*HPCLPLPCRPMKLT
PESCRG*LESSLQTTWSSRVALHLRVLVFPVKW
VSILGLCRPYDEVCV*CQ*ETQSGRLQNSTPRN
TQQPSVCSKATSLSCKQILLTPGFIFRKTKKPKY
YQQVGKIFLLKIYP*QLSV*KRNKMCHFQRCCI
AVVQG*GQAGQVNGWDRWLLPKDHLRPLTPCGQ
L*VAGFSPTCCATSCALRLD*LVFRS*LTVQPSP
RPTHTVTAFGQPASSGRCPPSDTPSPSGEVGAP
LDWVSRCESLWEL*GDFMVVPCRWFCHPC*FSL
VPVCVHSRTRGVGETCLQMTLNQLGSTLNSIVCK
KHPQAPS*VT*LLLFGNFRL*KLSYVLCPDSVT
TSYCIRTHQVPTYK*H*SGCILIHH*PVF*DPA
YVAFVLQFPWLTCVLH**ILTG*LPLYLCNTAVN
NCRFLNNLLC*FYKNKTFN*F

Sequence BCL2L11.qAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTAACTGGGACTAGAAACAGCTCCATCACCCAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCG
TATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGATGCCTCTTCCACCTGATTAAGAACCACTGTAGCAGACGCAGACTTATTGGACACTAGGCGGG
AGGCCAGCTCTGCAGACAGCAGGTCTCAGGAAGACGGTCAAGGCATGGCTGCTGATGATCCGCTTATGGGTATTTTTGAATAATTACCAAGCAGCCGAAG
ACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAG
ACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTT
CAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTT
TGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTT
TCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTG
CAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTT
CCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCC
TGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCAT
CACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATAT
CTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATT
CTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCA
CTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGG
CAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATC
CCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCA
GCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCA
GGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCG
TTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATT
TAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTT
CAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCT
GATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAA
GATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCC
TGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGC
CTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTT
AAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTT
AAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAA
GTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAAT
TTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTAT
ATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTAC
AGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTT
TCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCT
GCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCT
GGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAA
AATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGA
AAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCA
CTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCA
CTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAAT
TAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTC
AGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCAT
CCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTC
TAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTT
ATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCT
GTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACT
TGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ANWD*KQLHHPASMRQAEPADMRPEIWIAQELRR
IGDEFNAYYARRMPLPPD*EPL*QTQTYWTLGG
RPALQTAGLRKTVKAWLLMIRLWVFLNNYQAAE
DHPRMVILRLLRYIVRLVWRMH*QVLCGAEIPCR
HFACSNQQDPAPRSPGAIIMQPAVLLWRGQVTF
QKTPSWMGLPFCSSPHSRISNGSLL*M*RREHS
LLFNIQTMVFWSRILCKNGVYMQCVFPLTFNKVF
QKGNGNFLTNL*ITFVLKF*EPTAYSQRIM*PL
QWKLSQLT*KAALVYF*RLQNF*TGRRVIYSLP
SLLLPL*PF*IIFNTKRVLLKWN*LKGQRVCCQP
ALIYQSHL*IFTYLYKFSCICGKISDYFCVFPH
HFL*CNSSLDSDA*IWSSVFS**SEIESEQELI
SACILHSSSDLLLTGKHLVLVFIPFRRACYWEVF
*RGNSSNNNRLKCYAPLCCWLFWLQAFPWSQDA
LSASGPRGPPCPLQQSPAAASSSRPHGNWHRPG
AGLLMAICLASCILVQLTVH*LHSFKFTLKQASS
HFHQHHRRIILGRSLFFFIFPGQLDIVRPLVTP
AM**GCSFSVPAPYECSGRKPHTGQSFQRQQMP
RETQERVRLGSSESEEGRQFCELCNS*NF*KLHR
*TTFKRNN*IFK*VSSATN*CFAR*KSQHVHVI
*IRWKNLNIFIFII*KIYMYILHIHFFL*VEMI
SIQILLL*KISFPQESPWDFDLFLKLCWSSSCSL
MCLEPIGRVIQSPRLQAVVGLQPWACWTHTYTK
DVFGSGHPLPGSLYSRASLLTRALYSVSSALQP
LGAHTGCSPGPGTGGPALCCPGAVCTT*AHFPLA
WRPPGWLWKQFLRKLEIL*IVGVLKTRLLAPEL
KAMTGCLCTVCIWLSRCLCAESMPPVGIRFYLF
*KTFL*KK*LNPLFGNLLQVLCLDNLSLCEVCKK
CPVT*HRNAINTHKIVS*VILQMPFPTG*LIKN
FGGGGCGEIKFKIPSD*KNIVEYNCLPFPLLNV
YIVSIY*IRRSYYLSTEPNVCVQLCFLYLVKFCT
A*ISKKITVFLNFFKIKDCKYCRFFFCVMCPTV
S*CCNL*KYCIFIFCLFNVLISEKY*HPCLPLP
CRPMKLTPESCRG*LESSLQTTWSSRVALHLRVL
VFPVKWVSILGLCRPYDEVCV*CQ*ETQSGRLQ
NSTPRNTQQPSVCSKATSLSCKQILLTPGFIFR
KTKKPKYYQQVGKIFLLKIYP*QLSV*KRNKMCH
FQRCCIAVVQG*GQAGQVNGWDRWLLPKDHLRP
LTPCGQL*VAGFSPTCCATSCALRLD*LVFRS*
LTVQPSPRPTHTVTAFGQPASSGRCPPSDTPSPS
GEVGAPLDWVSRCESLWEL*GDFMVVPCRWFCH
PC*FSLVPVCVHSRTRGVGETCLQMTLNQLGST
LNSIVCKKHPQAPS*VT*LLLFGNFRL*KLSYVL
CPDSVTTSYCIRTHQVPTYK*H*SGCILIHH*P
VF*DPAYVAFVLQFPWLTCVLH**ILTG*LPLY
LCNTAVNNCRFLNNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LTGTRNSSITQLP*GRLNLQICAQRYGSPKSCG
VLETSLTLTMQGGCLFHLIKNHCSRRRLIGH*AG
GQLCRQQVSGRRSRHGC**SAYGYF*IITKQPK
TTHEWLSYDCYVTLSAWCGECIDRFFAEPRYHA
DILLVQTNKTQHRGLLVPLLCSQRFSCGGGR*RF
RRHRAGWDYLSVHHHTAEFLMEVCCECKGGSIL
CFLIYKPWFFGAGFCVRMVFTCSVFSPSPSIRF
FKKEMETF*PICE*LLY*NFKNLRPILRGLCNPC
SGN*AS*LKKLP*FIFRDYRIFKQGDV*YTPSL
PYYCLSDLFKLFLIPKEFF*NGTD*KGRGSVAS
LH*YTSPICKYLRTFINSVASVAKFQTIFASFLI
TFCDATPVWTQMHRFGPVYFHDKVKLSQNKS*Y
LPVSCTVRAICY*LGSIWCWFSFHFDEHVIGKY
SEEAIAVITTDLSATPLCAAGFSGCRLSHGHRMH
CQHQVPEGHRVHYSRVQLQHPAHALMGIGTGLG
QGF*WPFAWPPAF*SNSQSTSFTPLNSL*NRPH
PTSTSTIEE*FWAEVCFFSFFQDSWILSGHL*PQ
PCSEGALSLCLLLMSAVEGSHTLVSHFRGSRCP
GRPKKESG*GAVKVRREDNSVNSVTLKIFENSI
VKQLLKEITKFSNE*AVPPTSVLPDRRASMFTLF
KLGGKI*TFLSS*FKKYICIYCIFTFSFR*R*F
QSKYSYFKKFPFPKNLLGTLTYF*SCVGAHLVP
*CVSSPLVGSYKAHGYKQW*DCSRGPAGHTHTPK
MYLDLGTPSQDPCTHVPVS*LEHFTLFPQPCSP
WEHTLGAALGQAREALPCAAQGLCAPHEHISLW
PGGLQAGCGNSS*GN*RFYEL*EY*RPGCWHQNL
KR*LDVSVLYVSGYQDASVQKVCLPWVYVFTFF
KKHFCRKNN*IPFLETYCRFCALTTSPYVRFVK
SVL*LNTETQ*THTK*FHE*FFRCPSQLVS*SRI
LGVGVAEKSSLKFLLIKKI*WNTIVCRFPFLMY
IL*VFIRFVGHITYQLSQMSVCNCVSFTL*NFV
QHK*VKKSLFFSTFSKSRIVNIVDSFSV*CVLLF
HNAVTCRNIVYLFSAYLMS*FLKSINIPVSHSP
AVP*S*LLRVVGGDWRAHCRPRGPPGWLSTFGS
WYFQSSGFQFLGFAALMMKCVFDASEKLSLAGYK
ILLQEIPSNLLFVPKQLAYHASKFC*LQALSLG
KQKNQSIISRWERFFY*KFIPDNSAFRKEIKCA
TSRGAALQLFRARARQDK*MGGTGGSCLRTTSGH
*PLVDNCE*LGFPPPAVQLPVL*GWTNLSSGAN
*LYSPPHAPPIRSLHLVSLLLQVDALLLILHLL
QGRLGPHWTGCQDVKAYGSFKETSWWFHAGGSAI
PADLAWCLCVSTHVHVGWGKRVYR*R*ISWGLL
*TALCVRSILKLPVK*LDYFYLGISDYRSSLMF
YVQIL*PLVTVSELIRYPLINSTDLAVY*SITNL
FSRTQRM*HLYCSFPGLLVFCTDEF*QGNCHFT
CAILL*ITADF*TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
*LGLETAPSPSFHEAG*TCRYAPRDMDRPRVAA
YWRRV*RLLCKEDASST*LRTTVADADLLDTRR
EASSADSRSQEDGQGMAADDPLMGIFE*LPSSRR
PPTNGYLTTVTLHCPPGVENALTGSLRSRDTMQ
TFCLFKPTRPSTAVSWCHYYAASGSLVEGAGDV
SEDTELDGTTFLFITTQQNF*WKFVVNVKEGAFF
AF*YTNHGFLEQDFV*EWCLHAVCFPPHLQ*GF
SKRKWKLFNQFVNNFCIKILRTYGLFSEDYVTP
AVETEPANLKSCLSLFLEITEFLNRETCDILPPF
PTIASLTFLNYF*YQKSSFEMELIKRAEGLLPA
CIDIPVPFVNIYVPL*IQLHLWQNFRLFLRLSS
SLFVMQLQSGLRCIDLVQCIFMIK*N*VRTRVNI
CLYLAQFERSVINWEAFGVGFHSISTSMLLGSI
LKRQ*Q**QQT*VLRPFVLLAFLVAGFPMVTGC
TVSIRSQRATVSITAESSCSIQLTPSWELAQAWG
RASDGHLLGLLHFSPTHSPLASLL*IHFETGLI
PLPPAP*KNNSGQKSVFFHFSRTVGYCQATCDP
SHVVRVLFLCACSL*VQWKEATHWSVISEAADAQ
GDPRKSQVREQ*K*GGKTIL*TL*LLKFLKTPS
LNNF*KK*LNFQMSKQCHQLVFCPIEEPACSRY
LN*VEKSKHFYLHNLKNIYVYIAYSLFPLGRDDF
NPNTLTLKNFLSPRISLGL*LIFKAVLELILFP
DVSRAHW*GHTKPTVTSSGRIAAVGLLDTHIHQ
RCIWIWAPPPRIPVLTCQSPD*STLLCFLSPAAP
GSTHWVQPWARHGRPCPVLPRGCVHHMSTFPSG
LAASRLAVETVPEEIRDSMNCRSIKDQAVGTRT
*SDDWMSLYCMYLVIKMPLCRKYASRGYTFLPFL
KNIFVEKIIKSPFWKLTAGFVP*QPLPM*GL*K
VSCDLTQKRNKHTQNSFMSDSSDALPNWLVDQE
FWGWGLRRNQV*NSF*LKKYSGIQLSAVSPS*CI
YCEYLLDS*VILLIN*AKCLCAIVFPLPCKILY
SINK*KNHCFSQLFQNQGL*IL*ILFLCDVSYC
FIML*LVEILYIYFLLI*CLNF*KVLTSLSPTPL
PSHEVNS*ELSGVTGELIADHVVLQGGSPPSGP
GISSQVGFNSWALPPL**SVCLMPVRNSVWQAT
KFYSKKYPATFCLFQSN*LIMQANFADSRLYL*E
NKKTKVLSAGGKDFSIENLSLTTQRLEKK*NVP
LPEVLHCSCSGLGPGRTSEWVGQVAPA*GPPQA
TNPLWTTVSSWVFPHLLCNFLCFEVGLTCLQELI
NCTALPTPHPYGHCIWSACFFRSMPSF*YSISF
RGGWGPTGLGVKM*KLMGALRRLHGGSMQVVLP
SLLI*PGACVCPLTYTWGGGNVSTDDAKSVGVYS
KQHCV*EASSSSQLSNLTTFIWEFQTIEALLCF
MSRFCDH*LLYQNSSGTHL*IALIWLYTDPSLT
CFLGPSVCSICIAVSLAYLCFALMNFDRVIATLL
VQYCCK*LQIFKQSFMLIL*K*NFQLV

Sequence BCL2L11.fAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTAACTGGGACTAGAAACAGCTCCATCACCCAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCG
TATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTA
CGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAG
CACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTT
CTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGG
AGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATT
TGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGC
TGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATT
ATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATAT
TTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTC
AGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTG
TTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGAC
TTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTG
TCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCC
TGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTC
TGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCC
TGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGC
AGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTT
TCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTAT
CTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCC
TTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATAC
AAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGG
ATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCA
GGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGT
TCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATG
TATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAAT
CCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAA
ACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTT
TAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCA
TATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTC
TCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTAT
ATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGT
CGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTG
GGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTC
TGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTG
GGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGG
GCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGG
GTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCAT
ACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGT
CAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGT
CCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAA
GCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTA
TCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGT
ATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTT
TTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Exon skipping and alternative donor or acceptor

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ANWD*KQLHHPASMRQAEPADMRPEIWIAQELRR
IGDEFNAYYARRVFLNNYQAAEDHPRMVILRLL
RYIVRLVWRMH*QVLCGAEIPCRHFACSNQQDP
APRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPF
CSSPHSRISNGSLL*M*RREHSLLFNIQTMVFW
SRILCKNGVYMQCVFPLTFNKVFQKGNGNFLTN
L*ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KA
ALVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*I
IFNTKRVLLKWN*LKGQRVCCQPALIYQSHL*I
FTYLYKFSCICGKISDYFCVFPHHFL*CNSSLDS
DA*IWSSVFS**SEIESEQELISACILHSSSDL
LLTGKHLVLVFIPFRRACYWEVF*RGNSSNNNR
LKCYAPLCCWLFWLQAFPWSQDALSASGPRGPPC
PLQQSPAAASSSRPHGNWHRPGAGLLMAICLAS
CILVQLTVH*LHSFKFTLKQASSHFHQHHRRII
LGRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVP
APYECSGRKPHTGQSFQRQQMPRETQERVRLGS
SESEEGRQFCELCNS*NF*KLHR*TTFKRNN*I
FK*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFI
FII*KIYMYILHIHFFL*VEMISIQILLL*KIS
FPQESPWDFDLFLKLCWSSSCSLMCLEPIGRVI
QSPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPG
SLYSRASLLTRALYSVSSALQPLGAHTGCSPGP
GTGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQ
FLRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVC
IWLSRCLCAESMPPVGIRFYLF*KTFL*KK*LN
PLFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAI
NTHKIVS*VILQMPFPTG*LIKNFGGGGCGEIKF
KIPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRS
YYLSTEPNVCVQLCFLYLVKFCTA*ISKKITVF
LNFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCI
FIFCLFNVLISEKY*HPCLPLPCRPMKLTPESC
RG*LESSLQTTWSSRVALHLRVLVFPVKWVSIL
GLCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPS
VCSKATSLSCKQILLTPGFIFRKTKKPKYYQQV
GKIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQ
G*GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAG
FSPTCCATSCALRLD*LVFRS*LTVQPSPRPTH
TVTAFGQPASSGRCPPSDTPSPSGEVGAPLDWV
SRCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCV
HSRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQ
APS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYC
IRTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFV
LQFPWLTCVLH**ILTG*LPLYLCNTAVNNCRF
LNNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LTGTRNSSITQLP*GRLNLQICAQRYGSPKSCG
VLETSLTLTMQGGYF*IITKQPKTTHEWLSYDCY
VTLSAWCGECIDRFFAEPRYHADILLVQTNKTQ
HRGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYL
SVHHHTAEFLMEVCCECKGGSILCFLIYKPWFFG
AGFCVRMVFTCSVFSPSPSIRFFKKEMETF*PI
CE*LLY*NFKNLRPILRGLCNPCSGN*AS*LKK
LP*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKL
FLIPKEFF*NGTD*KGRGSVASLH*YTSPICKY
LRTFINSVASVAKFQTIFASFLITFCDATPVWT
QMHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAIC
Y*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTD
LSATPLCAAGFSGCRLSHGHRMHCQHQVPEGHR
VHYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPP
AF*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*F
WAEVCFFSFFQDSWILSGHL*PQPCSEGALSLC
LLLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GA
VKVRREDNSVNSVTLKIFENSIVKQLLKEITKF
SNE*AVPPTSVLPDRRASMFTLFKLGGKI*TFL
SS*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFP
FPKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSY
KAHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQ
DPCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQ
AREALPCAAQGLCAPHEHISLWPGGLQAGCGNS
S*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLY
VSGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*I
PFLETYCRFCALTTSPYVRFVKSVL*LNTETQ*
THTK*FHE*FFRCPSQLVS*SRILGVGVAEKSS
LKFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGH
ITYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFF
STFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIV
YLFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVV
GGDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFL
GFAALMMKCVFDASEKLSLAGYKILLQEIPSNL
LFVPKQLAYHASKFC*LQALSLGKQKNQSIISRW
ERFFY*KFIPDNSAFRKEIKCATSRGAALQLFR
ARARQDK*MGGTGGSCLRTTSGH*PLVDNCE*L
GFPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPI
RSLHLVSLLLQVDALLLILHLLQGRLGPHWTGC
QDVKAYGSFKETSWWFHAGGSAIPADLAWCLCV
STHVHVGWGKRVYR*R*ISWGLL*TALCVRSILK
LPVK*LDYFYLGISDYRSSLMFYVQIL*PLVTV
SELIRYPLINSTDLAVY*SITNLFSRTQRM*HL
YCSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF
*TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
*LGLETAPSPSFHEAG*TCRYAPRDMDRPRVAA
YWRRV*RLLCKEGIFE*LPSSRRPPTNGYLTTV
TLHCPPGVENALTGSLRSRDTMQTFCLFKPTRPS
TAVSWCHYYAASGSLVEGAGDVSEDTELDGTTF
LFITTQQNF*WKFVVNVKEGAFFAF*YTNHGFL
EQDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQF
VNNFCIKILRTYGLFSEDYVTPAVETEPANLKS
CLSLFLEITEFLNRETCDILPPFPTIASLTFLN
YF*YQKSSFEMELIKRAEGLLPACIDIPVPFVNI
YVPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGL
RCIDLVQCIFMIK*N*VRTRVNICLYLAQFERS
VINWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT
*VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATV
SITAESSCSIQLTPSWELAQAWGRASDGHLLGL
LHFSPTHSPLASLL*IHFETGLIPLPPAP*KNNS
GQKSVFFHFSRTVGYCQATCDPSHVVRVLFLCA
CSL*VQWKEATHWSVISEAADAQGDPRKSQVRE
Q*K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNF
QMSKQCHQLVFCPIEEPACSRYLN*VEKSKHFY
LHNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNF
LSPRISLGL*LIFKAVLELILFPDVSRAHW*GHT
KPTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPR
IPVLTCQSPD*STLLCFLSPAAPGSTHWVQPWA
RHGRPCPVLPRGCVHHMSTFPSGLAASRLAVETV
PEEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCM
YLVIKMPLCRKYASRGYTFLPFLKNIFVEKIIK
SPFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNK
HTQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV
*NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*V
ILLIN*AKCLCAIVFPLPCKILYSINK*KNHCFS
QLFQNQGL*IL*ILFLCDVSYCFIML*LVEILY
IYFLLI*CLNF*KVLTSLSPTPLPSHEVNS*EL
SGVTGELIADHVVLQGGSPPSGPGISSQVGFNSW
ALPPL**SVCLMPVRNSVWQATKFYSKKYPATF
CLFQSN*LIMQANFADSRLYL*ENKKTKVLSAG
GKDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSG
LGPGRTSEWVGQVAPA*GPPQATNPLWTTVSSW
VFPHLLCNFLCFEVGLTCLQELINCTALPTPHP
YGHCIWSACFFRSMPSF*YSISFRGGWGPTGLGV
KM*KLMGALRRLHGGSMQVVLPSLLI*PGACVC
PLTYTWGGGNVSTDDAKSVGVYSKQHCV*EASS
SSQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLY
QNSSGTHL*IALIWLYTDPSLTCFLGPSVCSIC
IAVSLAYLCFALMNFDRVIATLLVQYCCK*LQI
FKQSFMLIL*K*NFQLV

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