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Sequences

Sequence BCL2L11.cAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAG
GAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGACGGAGCTGTGGAGGCTGAAT
CCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACAT
TGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGG
TCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCAT
CACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGAT
TTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATA
ACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAG
TTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAA
TACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTAC
CTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCAT
AGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAAC
TGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGC
TACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTAC
AGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTT
AGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGA
AGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTT
ATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAG
TGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGA
GTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAA
TTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCA
AGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCA
CGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGT
ACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGG
AGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGG
AAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGT
TATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTT
TGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACAC
AAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTC
CTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTT
ATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTT
TTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTT
TCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTG
ACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGC
CGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTT
CCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGAT
TTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGC
CAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCC
CCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCAC
TGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGT
GAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCAC
GTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAG
TTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACT
CATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGT
TTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAA
TCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Single exon skipping

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYAR
RLEK*RKLSCSCHVFSPLKGSGEAFETELWRLN
P*RRR*ERHRYF*IITKQPKTTHEWLSYDCYVT
LSAWCGECIDRFFAEPRYHADILLVQTNKTQHRG
LLVPLLCSQRFSCGGGR*RFRRHRAGWDYLSVH
HHTAEFLMEVCCECKGGSILCFLIYKPWFFGAG
FCVRMVFTCSVFSPSPSIRFFKKEMETF*PICE*
LLY*NFKNLRPILRGLCNPCSGN*AS*LKKLP*
FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKLFL
IPKEFF*NGTD*KGRGSVASLH*YTSPICKYLRT
FINSVASVAKFQTIFASFLITFCDATPVWTQMH
RFGPVYFHDKVKLSQNKS*YLPVSCTVRAICY*
LGSIWCWFSFHFDEHVIGKYSEEAIAVITTDLSA
TPLCAAGFSGCRLSHGHRMHCQHQVPEGHRVHY
SRVQLQHPAHALMGIGTGLGQGF*WPFAWPPAF
*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*FWAE
VCFFSFFQDSWILSGHL*PQPCSEGALSLCLLL
MSAVEGSHTLVSHFRGSRCPGRPKKESG*GAVK
VRREDNSVNSVTLKIFENSIVKQLLKEITKFSNE
*AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS*
FKKYICIYCIFTFSFR*R*FQSKYSYFKKFPFP
KNLLGTLTYF*SCVGAHLVP*CVSSPLVGSYKAH
GYKQW*DCSRGPAGHTHTPKMYLDLGTPSQDPC
THVPVS*LEHFTLFPQPCSPWEHTLGAALGQAR
EALPCAAQGLCAPHEHISLWPGGLQAGCGNSS*G
N*RFYEL*EY*RPGCWHQNLKR*LDVSVLYVSG
YQDASVQKVCLPWVYVFTFFKKHFCRKNN*IPF
LETYCRFCALTTSPYVRFVKSVL*LNTETQ*THT
K*FHE*FFRCPSQLVS*SRILGVGVAEKSSLKF
LLIKKI*WNTIVCRFPFLMYIL*VFIRFVGHIT
YQLSQMSVCNCVSFTL*NFVQHK*VKKSLFFSTF
SKSRIVNIVDSFSV*CVLLFHNAVTCRNIVYLF
SAYLMS*FLKSINIPVSHSPAVP*S*LLRVVGG
DWRAHCRPRGPPGWLSTFGSWYFQSSGFQFLGFA
ALMMKCVFDASEKLSLAGYKILLQEIPSNLLFV
PKQLAYHASKFC*LQALSLGKQKNQSIISRWER
FFY*KFIPDNSAFRKEIKCATSRGAALQLFRARA
RQDK*MGGTGGSCLRTTSGH*PLVDNCE*LGFP
PPAVQLPVL*GWTNLSSGAN*LYSPPHAPPIRS
LHLVSLLLQVDALLLILHLLQGRLGPHWTGCQDV
KAYGSFKETSWWFHAGGSAIPADLAWCLCVSTH
VHVGWGKRVYR*R*ISWGLL*TALCVRSILKLP
VK*LDYFYLGISDYRSSLMFYVQIL*PLVTVSEL
IRYPLINSTDLAVY*SITNLFSRTQRM*HLYCS
FPGLLVFCTDEF*QGNCHFTCAILL*ITADF*T
IFYVNFIKIKLSTSF

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LP*GRLNLQICAQRYGSPKSCGVLETSLTLTMQ
GG*RNRGSCRVVVMYSVHLRAVGKRLRRSCGG*I
LEGGGERGTGIFE*LPSSRRPPTNGYLTTVTLH
CPPGVENALTGSLRSRDTMQTFCLFKPTRPSTA
VSWCHYYAASGSLVEGAGDVSEDTELDGTTFLFI
TTQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQD
FV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVN
NFCIKILRTYGLFSEDYVTPAVETEPANLKSCLS
LFLEITEFLNRETCDILPPFPTIASLTFLNYF*
YQKSSFEMELIKRAEGLLPACIDIPVPFVNIYV
PL*IQLHLWQNFRLFLRLSSSLFVMQLQSGLRCI
DLVQCIFMIK*N*VRTRVNICLYLAQFERSVIN
WEAFGVGFHSISTSMLLGSILKRQ*Q**QQT*V
LRPFVLLAFLVAGFPMVTGCTVSIRSQRATVSIT
AESSCSIQLTPSWELAQAWGRASDGHLLGLLHF
SPTHSPLASLL*IHFETGLIPLPPAP*KNNSGQ
KSVFFHFSRTVGYCQATCDPSHVVRVLFLCACSL
*VQWKEATHWSVISEAADAQGDPRKSQVREQ*K
*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNFQM
SKQCHQLVFCPIEEPACSRYLN*VEKSKHFYLHN
LKNIYVYIAYSLFPLGRDDFNPNTLTLKNFLSP
RISLGL*LIFKAVLELILFPDVSRAHW*GHTKP
TVTSSGRIAAVGLLDTHIHQRCIWIWAPPPRIPV
LTCQSPD*STLLCFLSPAAPGSTHWVQPWARHG
RPCPVLPRGCVHHMSTFPSGLAASRLAVETVPE
EIRDSMNCRSIKDQAVGTRT*SDDWMSLYCMYLV
IKMPLCRKYASRGYTFLPFLKNIFVEKIIKSPF
WKLTAGFVP*QPLPM*GL*KVSCDLTQKRNKHT
QNSFMSDSSDALPNWLVDQEFWGWGLRRNQV*NS
F*LKKYSGIQLSAVSPS*CIYCEYLLDS*VILL
IN*AKCLCAIVFPLPCKILYSINK*KNHCFSQL
FQNQGL*IL*ILFLCDVSYCFIML*LVEILYIYF
LLI*CLNF*KVLTSLSPTPLPSHEVNS*ELSGV
TGELIADHVVLQGGSPPSGPGISSQVGFNSWAL
PPL**SVCLMPVRNSVWQATKFYSKKYPATFCLF
QSN*LIMQANFADSRLYL*ENKKTKVLSAGGKD
FSIENLSLTTQRLEKK*NVPLPEVLHCSCSGLG
PGRTSEWVGQVAPA*GPPQATNPLWTTVSSWVFP
HLLCNFLCFEVGLTCLQELINCTALPTPHPYGH
CIWSACFFRSMPSF*YSISFRGGWGPTGLGVKM
*KLMGALRRLHGGSMQVVLPSLLI*PGACVCPLT
YTWGGGNVSTDDAKSVGVYSKQHCV*EASSSSQ
LSNLTTFIWEFQTIEALLCFMSRFCDH*LLYQN
SSGTHL*IALIWLYTDPSLTCFLGPSVCSICIAV
SLAYLCFALMNFDRVIATLLVQYCCK*LQIFKQ
SFMLIL*K*NFQLV

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
FHEAG*TCRYAPRDMDRPRVAAYWRRV*RLLCK
EVREIEEVVV*LSCIQST*GQWGSV*DGAVEAE
SLKEEVREAQVFLNNYQAAEDHPRMVILRLLRYI
VRLVWRMH*QVLCGAEIPCRHFACSNQQDPAPR
SPGAIIMQPAVLLWRGQVTFQKTPSWMGLPFCS
SPHSRISNGSLL*M*RREHSLLFNIQTMVFWSRI
LCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*I
TFVLKF*EPTAYSQRIM*PLQWKLSQLT*KAAL
VYF*RLQNF*TGRRVIYSLPSLLLPL*PF*IIFN
TKRVLLKWN*LKGQRVCCQPALIYQSHL*IFTY
LYKFSCICGKISDYFCVFPHHFL*CNSSLDSDA
*IWSSVFS**SEIESEQELISACILHSSSDLLLT
GKHLVLVFIPFRRACYWEVF*RGNSSNNNRLKC
YAPLCCWLFWLQAFPWSQDALSASGPRGPPCPL
QQSPAAASSSRPHGNWHRPGAGLLMAICLASCIL
VQLTVH*LHSFKFTLKQASSHFHQHHRRIILGR
SLFFFIFPGQLDIVRPLVTPAM**GCSFSVPAP
YECSGRKPHTGQSFQRQQMPRETQERVRLGSSES
EEGRQFCELCNS*NF*KLHR*TTFKRNN*IFK*
VSSATN*CFAR*KSQHVHVI*IRWKNLNIFIFI
I*KIYMYILHIHFFL*VEMISIQILLL*KISFPQ
ESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQSP
RLQAVVGLQPWACWTHTYTKDVFGSGHPLPGSL
YSRASLLTRALYSVSSALQPLGAHTGCSPGPGTG
GPALCCPGAVCTT*AHFPLAWRPPGWLWKQFLR
KLEIL*IVGVLKTRLLAPELKAMTGCLCTVCIW
LSRCLCAESMPPVGIRFYLF*KTFL*KK*LNPLF
GNLLQVLCLDNLSLCEVCKKCPVT*HRNAINTH
KIVS*VILQMPFPTG*LIKNFGGGGCGEIKFKI
PSD*KNIVEYNCLPFPLLNVYIVSIY*IRRSYYL
STEPNVCVQLCFLYLVKFCTA*ISKKITVFLNF
FKIKDCKYCRFFFCVMCPTVS*CCNL*KYCIFI
FCLFNVLISEKY*HPCLPLPCRPMKLTPESCRG*
LESSLQTTWSSRVALHLRVLVFPVKWVSILGLC
RPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVC
SKATSLSCKQILLTPGFIFRKTKKPKYYQQVGKI
FLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*G
QAGQVNGWDRWLLPKDHLRPLTPCGQL*VAGFS
PTCCATSCALRLD*LVFRS*LTVQPSPRPTHTVT
AFGQPASSGRCPPSDTPSPSGEVGAPLDWVSRC
ESLWEL*GDFMVVPCRWFCHPC*FSLVPVCVHS
RTRGVGETCLQMTLNQLGSTLNSIVCKKHPQAPS
*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIRT
HQVPTYK*H*SGCILIHH*PVF*DPAYVAFVLQ
FPWLTCVLH**ILTG*LPLYLCNTAVNNCRFLNN
LLC*FYKNKTFN*F

Sequence BCL2L11.bAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAG
GAGGATGCCTCTTCCACCTGATTAAGAACCACTGTAGCAGACGCAGACTTATTGGACACTAGGCGGGAGGCCAGCTCTGCAGACAGCAGGTCTCAGGAAG
ACGGTCAAGGCATGGCTGCTGATGATCCGCTTATGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTAC
GTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGC
ACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTC
TGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGA
GCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTT
GTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCT
GCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTA
TTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATT
TACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCA
GATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGT
TATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACT
TAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGT
CCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCT
GCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCT
GGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCT
GCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCA
GTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTT
CAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATC
TTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCT
TTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACA
AAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGA
TCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAG
GCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTT
CCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGT
ATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATC
CCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAA
CACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTT
AAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCAT
ATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCT
CAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATA
TTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTC
GGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGG
GCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCT
GTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGG
GAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGG
CTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGG
TTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATA
CGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTC
AAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTC
CACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAG
CTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTAT
CAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTA
TTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTT
TAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Single exon skipping

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ASMRQAEPADMRPEIWIAQELRRIGDEFNAYYAR
RMPLPPD*EPL*QTQTYWTLGGRPALQTAGLRK
TVKAWLLMIRLWVFLNNYQAAEDHPRMVILRLL
RYIVRLVWRMH*QVLCGAEIPCRHFACSNQQDPA
PRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPF
CSSPHSRISNGSLL*M*RREHSLLFNIQTMVFW
SRILCKNGVYMQCVFPLTFNKVFQKGNGNFLTNL
*ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KA
ALVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*I
IFNTKRVLLKWN*LKGQRVCCQPALIYQSHL*IF
TYLYKFSCICGKISDYFCVFPHHFL*CNSSLDS
DA*IWSSVFS**SEIESEQELISACILHSSSDL
LLTGKHLVLVFIPFRRACYWEVF*RGNSSNNNRL
KCYAPLCCWLFWLQAFPWSQDALSASGPRGPPC
PLQQSPAAASSSRPHGNWHRPGAGLLMAICLAS
CILVQLTVH*LHSFKFTLKQASSHFHQHHRRIIL
GRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVP
APYECSGRKPHTGQSFQRQQMPRETQERVRLGS
SESEEGRQFCELCNS*NF*KLHR*TTFKRNN*IF
K*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFI
FII*KIYMYILHIHFFL*VEMISIQILLL*KIS
FPQESPWDFDLFLKLCWSSSCSLMCLEPIGRVIQ
SPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPG
SLYSRASLLTRALYSVSSALQPLGAHTGCSPGP
GTGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQF
LRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVC
IWLSRCLCAESMPPVGIRFYLF*KTFL*KK*LN
PLFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAIN
THKIVS*VILQMPFPTG*LIKNFGGGGCGEIKF
KIPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRS
YYLSTEPNVCVQLCFLYLVKFCTA*ISKKITVFL
NFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCI
FIFCLFNVLISEKY*HPCLPLPCRPMKLTPESC
RG*LESSLQTTWSSRVALHLRVLVFPVKWVSILG
LCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPS
VCSKATSLSCKQILLTPGFIFRKTKKPKYYQQV
GKIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQG
*GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAG
FSPTCCATSCALRLD*LVFRS*LTVQPSPRPTH
TVTAFGQPASSGRCPPSDTPSPSGEVGAPLDWVS
RCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCV
HSRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQ
APS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYCI
RTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFV
LQFPWLTCVLH**ILTG*LPLYLCNTAVNNCRF
LNNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LP*GRLNLQICAQRYGSPKSCGVLETSLTLTMQ
GGCLFHLIKNHCSRRRLIGH*AGGQLCRQQVSGR
RSRHGC**SAYGYF*IITKQPKTTHEWLSYDCY
VTLSAWCGECIDRFFAEPRYHADILLVQTNKTQ
HRGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYLS
VHHHTAEFLMEVCCECKGGSILCFLIYKPWFFG
AGFCVRMVFTCSVFSPSPSIRFFKKEMETF*PI
CE*LLY*NFKNLRPILRGLCNPCSGN*AS*LKKL
P*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKL
FLIPKEFF*NGTD*KGRGSVASLH*YTSPICKY
LRTFINSVASVAKFQTIFASFLITFCDATPVWTQ
MHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAIC
Y*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTD
LSATPLCAAGFSGCRLSHGHRMHCQHQVPEGHRV
HYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPP
AF*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*F
WAEVCFFSFFQDSWILSGHL*PQPCSEGALSLCL
LLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GA
VKVRREDNSVNSVTLKIFENSIVKQLLKEITKF
SNE*AVPPTSVLPDRRASMFTLFKLGGKI*TFLS
S*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFP
FPKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSY
KAHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQD
PCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQ
AREALPCAAQGLCAPHEHISLWPGGLQAGCGNS
S*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLYV
SGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*I
PFLETYCRFCALTTSPYVRFVKSVL*LNTETQ*
THTK*FHE*FFRCPSQLVS*SRILGVGVAEKSSL
KFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGH
ITYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFF
STFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIVY
LFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVV
GGDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFL
GFAALMMKCVFDASEKLSLAGYKILLQEIPSNLL
FVPKQLAYHASKFC*LQALSLGKQKNQSIISRW
ERFFY*KFIPDNSAFRKEIKCATSRGAALQLFR
ARARQDK*MGGTGGSCLRTTSGH*PLVDNCE*LG
FPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPI
RSLHLVSLLLQVDALLLILHLLQGRLGPHWTGC
QDVKAYGSFKETSWWFHAGGSAIPADLAWCLCVS
THVHVGWGKRVYR*R*ISWGLL*TALCVRSILK
LPVK*LDYFYLGISDYRSSLMFYVQIL*PLVTV
SELIRYPLINSTDLAVY*SITNLFSRTQRM*HLY
CSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF
*TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
FHEAG*TCRYAPRDMDRPRVAAYWRRV*RLLCK
EDASST*LRTTVADADLLDTRREASSADSRSQE
DGQGMAADDPLMGIFE*LPSSRRPPTNGYLTTVT
LHCPPGVENALTGSLRSRDTMQTFCLFKPTRPS
TAVSWCHYYAASGSLVEGAGDVSEDTELDGTTF
LFITTQQNF*WKFVVNVKEGAFFAF*YTNHGFLE
QDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQF
VNNFCIKILRTYGLFSEDYVTPAVETEPANLKS
CLSLFLEITEFLNRETCDILPPFPTIASLTFLNY
F*YQKSSFEMELIKRAEGLLPACIDIPVPFVNI
YVPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGL
RCIDLVQCIFMIK*N*VRTRVNICLYLAQFERSV
INWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT
*VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATV
SITAESSCSIQLTPSWELAQAWGRASDGHLLGLL
HFSPTHSPLASLL*IHFETGLIPLPPAP*KNNS
GQKSVFFHFSRTVGYCQATCDPSHVVRVLFLCA
CSL*VQWKEATHWSVISEAADAQGDPRKSQVREQ
*K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNF
QMSKQCHQLVFCPIEEPACSRYLN*VEKSKHFY
LHNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNFL
SPRISLGL*LIFKAVLELILFPDVSRAHW*GHT
KPTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPR
IPVLTCQSPD*STLLCFLSPAAPGSTHWVQPWAR
HGRPCPVLPRGCVHHMSTFPSGLAASRLAVETV
PEEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCM
YLVIKMPLCRKYASRGYTFLPFLKNIFVEKIIKS
PFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNK
HTQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV
*NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*VI
LLIN*AKCLCAIVFPLPCKILYSINK*KNHCFS
QLFQNQGL*IL*ILFLCDVSYCFIML*LVEILY
IYFLLI*CLNF*KVLTSLSPTPLPSHEVNS*ELS
GVTGELIADHVVLQGGSPPSGPGISSQVGFNSW
ALPPL**SVCLMPVRNSVWQATKFYSKKYPATF
CLFQSN*LIMQANFADSRLYL*ENKKTKVLSAGG
KDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSG
LGPGRTSEWVGQVAPA*GPPQATNPLWTTVSSW
VFPHLLCNFLCFEVGLTCLQELINCTALPTPHPY
GHCIWSACFFRSMPSF*YSISFRGGWGPTGLGV
KM*KLMGALRRLHGGSMQVVLPSLLI*PGACVC
PLTYTWGGGNVSTDDAKSVGVYSKQHCV*EASSS
SQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLY
QNSSGTHL*IALIWLYTDPSLTCFLGPSVCSIC
IAVSLAYLCFALMNFDRVIATLLVQYCCK*LQIF
KQSFMLIL*K*NFQLV

Sequence BCL2L11.aAug05

GCCGCCTGGTCTGCAGTTTGTTGGAGCTCTGCGTCCAGCGCCGCTGCCGCTGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCACTACCA
CCACTTGATTCTTGCAGCCACCCTGCGAACCCTGCCACACTGCGATCGCATCATCGCGGTATTCGGTTCGCTGCGTTCCCGCCGCCACCGCCTCGGCGCC
CTTTCTTGGCCCTTGTTCCCCCAAATGTCTGACTCTGACTCTCGGACTGAGAAACGCAAGAAAAAAAGACCAAATGGCAAAGCAACCTTCTGATGTAAGT
TCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGGTA
ATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGCCCCACCTGCCAGCCCTGGCCCTTTTGCTACCAG
ATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCTTTTGACACAGACAGGAGCCCAGCACCCATGAGT
TGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGC
GCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGA
AGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGC
AGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGT
TTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTC
TTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTT
TTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCC
TGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCC
TTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAG
CCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTC
ATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAAT
ATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTA
TTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATG
CACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGG
GGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCA
TCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCC
CAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCC
CAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCAT
CGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTA
TTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGAT
TTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCC
CTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCA
AAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCC
CCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTG
GCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAAC
TTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTT
TTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAA
AAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGA
ATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGT
ATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGT
ACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTG
TTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCC
CTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTC
CTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTAC
AAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAG
GAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGC
CACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGC
CACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTA
ATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCT
TCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCC
ATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTAC
TCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTT
TTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAAC
CTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTA
CTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Single exon skipping

Frame 0

AAWSAVCWSSASSAAAAAAAAAAAAAAAAAATT
TT*FLQPPCEPCHTAIASSRYSVRCVPAATASAP
FLGPCSPKCLTLTLGLRNARKKDQMAKQPSDVS
SECDREGRQLQPAERPPQLRPGAPTSLQTEPQG
NPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATR
SPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMS
CDKSTQTPSPPCQAFNHYLSAMASMRQAEPADM
RPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAE
DHPRMVILRLLRYIVRLVWRMH*QVLCGAEIPC
RHFACSNQQDPAPRSPGAIIMQPAVLLWRGQVT
FQKTPSWMGLPFCSSPHSRISNGSLL*M*RREHS
LLFNIQTMVFWSRILCKNGVYMQCVFPLTFNKV
FQKGNGNFLTNL*ITFVLKF*EPTAYSQRIM*P
LQWKLSQLT*KAALVYF*RLQNF*TGRRVIYSLP
SLLLPL*PF*IIFNTKRVLLKWN*LKGQRVCCQ
PALIYQSHL*IFTYLYKFSCICGKISDYFCVFP
HHFL*CNSSLDSDA*IWSSVFS**SEIESEQELI
SACILHSSSDLLLTGKHLVLVFIPFRRACYWEV
F*RGNSSNNNRLKCYAPLCCWLFWLQAFPWSQD
ALSASGPRGPPCPLQQSPAAASSSRPHGNWHRPG
AGLLMAICLASCILVQLTVH*LHSFKFTLKQAS
SHFHQHHRRIILGRSLFFFIFPGQLDIVRPLVT
PAM**GCSFSVPAPYECSGRKPHTGQSFQRQQMP
RETQERVRLGSSESEEGRQFCELCNS*NF*KLH
R*TTFKRNN*IFK*VSSATN*CFAR*KSQHVHV
I*IRWKNLNIFIFII*KIYMYILHIHFFL*VEMI
SIQILLL*KISFPQESPWDFDLFLKLCWSSSCS
LMCLEPIGRVIQSPRLQAVVGLQPWACWTHTYT
KDVFGSGHPLPGSLYSRASLLTRALYSVSSALQP
LGAHTGCSPGPGTGGPALCCPGAVCTT*AHFPL
AWRPPGWLWKQFLRKLEIL*IVGVLKTRLLAPE
LKAMTGCLCTVCIWLSRCLCAESMPPVGIRFYLF
*KTFL*KK*LNPLFGNLLQVLCLDNLSLCEVCK
KCPVT*HRNAINTHKIVS*VILQMPFPTG*LIK
NFGGGGCGEIKFKIPSD*KNIVEYNCLPFPLLNV
YIVSIY*IRRSYYLSTEPNVCVQLCFLYLVKFC
TA*ISKKITVFLNFFKIKDCKYCRFFFCVMCPT
VS*CCNL*KYCIFIFCLFNVLISEKY*HPCLPLP
CRPMKLTPESCRG*LESSLQTTWSSRVALHLRV
LVFPVKWVSILGLCRPYDEVCV*CQ*ETQSGRL
QNSTPRNTQQPSVCSKATSLSCKQILLTPGFIFR
KTKKPKYYQQVGKIFLLKIYP*QLSV*KRNKMC
HFQRCCIAVVQG*GQAGQVNGWDRWLLPKDHLR
PLTPCGQL*VAGFSPTCCATSCALRLD*LVFRS*
LTVQPSPRPTHTVTAFGQPASSGRCPPSDTPSP
SGEVGAPLDWVSRCESLWEL*GDFMVVPCRWFC
HPC*FSLVPVCVHSRTRGVGETCLQMTLNQLGST
LNSIVCKKHPQAPS*VT*LLLFGNFRL*KLSYV
LCPDSVTTSYCIRTHQVPTYK*H*SGCILIHH*
PVF*DPAYVAFVLQFPWLTCVLH**ILTG*LPLY
LCNTAVNNCRFLNNLLC*FYKNKTFN*F

Frame 1

PPGLQFVGALRPAPLPLPPPPPPPPPPPPPPLP
PLDSCSHPANPATLRSHHRGIRFAAFPPPPPRR
PFLALVPPNV*L*LSD*ETQEKKTKWQSNLLM*V
LSVTEKVDNCSLRRGLPSSDLGPLPPYRQSHKV
ILKAITEVKGTAAPTAALRARWPHLPALALLLP
DPRFSSL*EDPPCCLDPPVGISLLTQTGAQHP*V
VTNQHKPQVLLARPSTTISVQWLP*GRLNLQIC
AQRYGSPKSCGVLETSLTLTMQGGYF*IITKQP
KTTHEWLSYDCYVTLSAWCGECIDRFFAEPRYHA
DILLVQTNKTQHRGLLVPLLCSQRFSCGGGR*R
FRRHRAGWDYLSVHHHTAEFLMEVCCECKGGSI
LCFLIYKPWFFGAGFCVRMVFTCSVFSPSPSIRF
FKKEMETF*PICE*LLY*NFKNLRPILRGLCNP
CSGN*AS*LKKLP*FIFRDYRIFKQGDV*YTPS
LPYYCLSDLFKLFLIPKEFF*NGTD*KGRGSVAS
LH*YTSPICKYLRTFINSVASVAKFQTIFASFL
ITFCDATPVWTQMHRFGPVYFHDKVKLSQNKS*
YLPVSCTVRAICY*LGSIWCWFSFHFDEHVIGKY
SEEAIAVITTDLSATPLCAAGFSGCRLSHGHRM
HCQHQVPEGHRVHYSRVQLQHPAHALMGIGTGL
GQGF*WPFAWPPAF*SNSQSTSFTPLNSL*NRPH
PTSTSTIEE*FWAEVCFFSFFQDSWILSGHL*P
QPCSEGALSLCLLLMSAVEGSHTLVSHFRGSRC
PGRPKKESG*GAVKVRREDNSVNSVTLKIFENSI
VKQLLKEITKFSNE*AVPPTSVLPDRRASMFTL
FKLGGKI*TFLSS*FKKYICIYCIFTFSFR*R*
FQSKYSYFKKFPFPKNLLGTLTYF*SCVGAHLVP
*CVSSPLVGSYKAHGYKQW*DCSRGPAGHTHTP
KMYLDLGTPSQDPCTHVPVS*LEHFTLFPQPCS
PWEHTLGAALGQAREALPCAAQGLCAPHEHISLW
PGGLQAGCGNSS*GN*RFYEL*EY*RPGCWHQN
LKR*LDVSVLYVSGYQDASVQKVCLPWVYVFTF
FKKHFCRKNN*IPFLETYCRFCALTTSPYVRFVK
SVL*LNTETQ*THTK*FHE*FFRCPSQLVS*SR
ILGVGVAEKSSLKFLLIKKI*WNTIVCRFPFLM
YIL*VFIRFVGHITYQLSQMSVCNCVSFTL*NFV
QHK*VKKSLFFSTFSKSRIVNIVDSFSV*CVLL
FHNAVTCRNIVYLFSAYLMS*FLKSINIPVSHS
PAVP*S*LLRVVGGDWRAHCRPRGPPGWLSTFGS
WYFQSSGFQFLGFAALMMKCVFDASEKLSLAGY
KILLQEIPSNLLFVPKQLAYHASKFC*LQALSL
GKQKNQSIISRWERFFY*KFIPDNSAFRKEIKCA
TSRGAALQLFRARARQDK*MGGTGGSCLRTTSG
H*PLVDNCE*LGFPPPAVQLPVL*GWTNLSSGA
N*LYSPPHAPPIRSLHLVSLLLQVDALLLILHLL
QGRLGPHWTGCQDVKAYGSFKETSWWFHAGGSA
IPADLAWCLCVSTHVHVGWGKRVYR*R*ISWGL
L*TALCVRSILKLPVK*LDYFYLGISDYRSSLMF
YVQIL*PLVTVSELIRYPLINSTDLAVY*SITN
LFSRTQRM*HLYCSFPGLLVFCTDEF*QGNCHF
TCAILL*ITADF*TIFYVNFIKIKLSTSF

Frame 2

RLVCSLLELCVQRRCRCRRRRRRRRRRRRRHYH
HLILAATLRTLPHCDRIIAVFGSLRSRRHRLGA
LSWPLFPQMSDSDSRTEKRKKKRPNGKATF*CK
F*V*PRR*TIAACGEASPAQTWGPYLPTDRATR*
S*RQSRR*RGQLPPRQPSGPAGPTCQPWPFCYQ
IPAFHLYEKILPAVSILQWVFLF*HRQEPSTHE
L*QINTNPKSSLPGLQPLSQCNGFHEAG*TCRYA
PRDMDRPRVAAYWRRV*RLLCKEGIFE*LPSSR
RPPTNGYLTTVTLHCPPGVENALTGSLRSRDTM
QTFCLFKPTRPSTAVSWCHYYAASGSLVEGAGDV
SEDTELDGTTFLFITTQQNF*WKFVVNVKEGAF
FAF*YTNHGFLEQDFV*EWCLHAVCFPPHLQ*G
FSKRKWKLFNQFVNNFCIKILRTYGLFSEDYVTP
AVETEPANLKSCLSLFLEITEFLNRETCDILPP
FPTIASLTFLNYF*YQKSSFEMELIKRAEGLLP
ACIDIPVPFVNIYVPL*IQLHLWQNFRLFLRLSS
SLFVMQLQSGLRCIDLVQCIFMIK*N*VRTRVN
ICLYLAQFERSVINWEAFGVGFHSISTSMLLGS
ILKRQ*Q**QQT*VLRPFVLLAFLVAGFPMVTGC
TVSIRSQRATVSITAESSCSIQLTPSWELAQAW
GRASDGHLLGLLHFSPTHSPLASLL*IHFETGL
IPLPPAP*KNNSGQKSVFFHFSRTVGYCQATCDP
SHVVRVLFLCACSL*VQWKEATHWSVISEAADA
QGDPRKSQVREQ*K*GGKTIL*TL*LLKFLKTP
SLNNF*KK*LNFQMSKQCHQLVFCPIEEPACSRY
LN*VEKSKHFYLHNLKNIYVYIAYSLFPLGRDD
FNPNTLTLKNFLSPRISLGL*LIFKAVLELILF
PDVSRAHW*GHTKPTVTSSGRIAAVGLLDTHIHQ
RCIWIWAPPPRIPVLTCQSPD*STLLCFLSPAA
PGSTHWVQPWARHGRPCPVLPRGCVHHMSTFPS
GLAASRLAVETVPEEIRDSMNCRSIKDQAVGTRT
*SDDWMSLYCMYLVIKMPLCRKYASRGYTFLPF
LKNIFVEKIIKSPFWKLTAGFVP*QPLPM*GL*
KVSCDLTQKRNKHTQNSFMSDSSDALPNWLVDQE
FWGWGLRRNQV*NSF*LKKYSGIQLSAVSPS*C
IYCEYLLDS*VILLIN*AKCLCAIVFPLPCKIL
YSINK*KNHCFSQLFQNQGL*IL*ILFLCDVSYC
FIML*LVEILYIYFLLI*CLNF*KVLTSLSPTP
LPSHEVNS*ELSGVTGELIADHVVLQGGSPPSG
PGISSQVGFNSWALPPL**SVCLMPVRNSVWQAT
KFYSKKYPATFCLFQSN*LIMQANFADSRLYL*
ENKKTKVLSAGGKDFSIENLSLTTQRLEKK*NV
PLPEVLHCSCSGLGPGRTSEWVGQVAPA*GPPQA
TNPLWTTVSSWVFPHLLCNFLCFEVGLTCLQEL
INCTALPTPHPYGHCIWSACFFRSMPSF*YSIS
FRGGWGPTGLGVKM*KLMGALRRLHGGSMQVVLP
SLLI*PGACVCPLTYTWGGGNVSTDDAKSVGVY
SKQHCV*EASSSSQLSNLTTFIWEFQTIEALLC
FMSRFCDH*LLYQNSSGTHL*IALIWLYTDPSLT
CFLGPSVCSICIAVSLAYLCFALMNFDRVIATL
LVQYCCK*LQIFKQSFMLIL*K*NFQLV

Sequence BCL2L11.jAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAA
CCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAG
TTTAACGCTTACTATGCAAGGAGGTTAGAGAAATAGAGGAAGTTGTCGTGTAGTTGTCATGTATTCAGTCCACTTAAGGGCAGTGGGGAAGCGTTTGAGA
CGGAGCTGTGGAGGCTGAATCCTTGAAGGAGGAGGTGAGAGAGGCACAGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATC
TTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACC
AACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGAT
GGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACC
ATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACT
TTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCT
AACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGA
CCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCC
ATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTC
CAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGT
TCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTA
ATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAG
AGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATT
TGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATA
GAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTC
TTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTC
AGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAA
ATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCT
AAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTT
TAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTG
GTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCA
CCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGC
AGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGC
TGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCT
CTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAA
AAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACA
GAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGG
AGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAG
ATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAA
TCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTA
GAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACT
CCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGG
TTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATAC
CCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTAT
TATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTG
CAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACT
GTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCA
CGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCAC
TGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGT
GCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAG
AAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCA
CTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTA
TGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAAT
AACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Single exon skipping

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFN
HYLSAMASMRQAEPADMRPEIWIAQELRRIGDE
FNAYYARRLEK*RKLSCSCHVFSPLKGSGEAFE
TELWRLNP*RRR*ERHRYF*IITKQPKTTHEWLS
YDCYVTLSAWCGECIDRFFAEPRYHADILLVQT
NKTQHRGLLVPLLCSQRFSCGGGR*RFRRHRAG
WDYLSVHHHTAEFLMEVCCECKGGSILCFLIYKP
WFFGAGFCVRMVFTCSVFSPSPSIRFFKKEMET
F*PICE*LLY*NFKNLRPILRGLCNPCSGN*AS
*LKKLP*FIFRDYRIFKQGDV*YTPSLPYYCLSD
LFKLFLIPKEFF*NGTD*KGRGSVASLH*YTSP
ICKYLRTFINSVASVAKFQTIFASFLITFCDAT
PVWTQMHRFGPVYFHDKVKLSQNKS*YLPVSCTV
RAICY*LGSIWCWFSFHFDEHVIGKYSEEAIAV
ITTDLSATPLCAAGFSGCRLSHGHRMHCQHQVP
EGHRVHYSRVQLQHPAHALMGIGTGLGQGF*WPF
AWPPAF*SNSQSTSFTPLNSL*NRPHPTSTSTI
EE*FWAEVCFFSFFQDSWILSGHL*PQPCSEGA
LSLCLLLMSAVEGSHTLVSHFRGSRCPGRPKKES
G*GAVKVRREDNSVNSVTLKIFENSIVKQLLKE
ITKFSNE*AVPPTSVLPDRRASMFTLFKLGGKI
*TFLSS*FKKYICIYCIFTFSFR*R*FQSKYSYF
KKFPFPKNLLGTLTYF*SCVGAHLVP*CVSSPL
VGSYKAHGYKQW*DCSRGPAGHTHTPKMYLDLG
TPSQDPCTHVPVS*LEHFTLFPQPCSPWEHTLGA
ALGQAREALPCAAQGLCAPHEHISLWPGGLQAG
CGNSS*GN*RFYEL*EY*RPGCWHQNLKR*LDV
SVLYVSGYQDASVQKVCLPWVYVFTFFKKHFCRK
NN*IPFLETYCRFCALTTSPYVRFVKSVL*LNT
ETQ*THTK*FHE*FFRCPSQLVS*SRILGVGVA
EKSSLKFLLIKKI*WNTIVCRFPFLMYIL*VFIR
FVGHITYQLSQMSVCNCVSFTL*NFVQHK*VKK
SLFFSTFSKSRIVNIVDSFSV*CVLLFHNAVTC
RNIVYLFSAYLMS*FLKSINIPVSHSPAVP*S*L
LRVVGGDWRAHCRPRGPPGWLSTFGSWYFQSSG
FQFLGFAALMMKCVFDASEKLSLAGYKILLQEI
PSNLLFVPKQLAYHASKFC*LQALSLGKQKNQSI
ISRWERFFY*KFIPDNSAFRKEIKCATSRGAAL
QLFRARARQDK*MGGTGGSCLRTTSGH*PLVDN
CE*LGFPPPAVQLPVL*GWTNLSSGAN*LYSPPH
APPIRSLHLVSLLLQVDALLLILHLLQGRLGPH
WTGCQDVKAYGSFKETSWWFHAGGSAIPADLAW
CLCVSTHVHVGWGKRVYR*R*ISWGLL*TALCVR
SILKLPVK*LDYFYLGISDYRSSLMFYVQIL*P
LVTVSELIRYPLINSTDLAVY*SITNLFSRTQR
M*HLYCSFPGLLVFCTDEF*QGNCHFTCAILL*I
TADF*TIFYVNFIKIKLSTSF

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKTGAQHP*VVTNQHKPQVLLARPS
TTISVQWLP*GRLNLQICAQRYGSPKSCGVLETS
LTLTMQGG*RNRGSCRVVVMYSVHLRAVGKRLR
RSCGG*ILEGGGERGTGIFE*LPSSRRPPTNGY
LTTVTLHCPPGVENALTGSLRSRDTMQTFCLFKP
TRPSTAVSWCHYYAASGSLVEGAGDVSEDTELD
GTTFLFITTQQNF*WKFVVNVKEGAFFAF*YTN
HGFLEQDFV*EWCLHAVCFPPHLQ*GFSKRKWKL
FNQFVNNFCIKILRTYGLFSEDYVTPAVETEPA
NLKSCLSLFLEITEFLNRETCDILPPFPTIASL
TFLNYF*YQKSSFEMELIKRAEGLLPACIDIPVP
FVNIYVPL*IQLHLWQNFRLFLRLSSSLFVMQL
QSGLRCIDLVQCIFMIK*N*VRTRVNICLYLAQ
FERSVINWEAFGVGFHSISTSMLLGSILKRQ*Q*
*QQT*VLRPFVLLAFLVAGFPMVTGCTVSIRSQ
RATVSITAESSCSIQLTPSWELAQAWGRASDGH
LLGLLHFSPTHSPLASLL*IHFETGLIPLPPAP*
KNNSGQKSVFFHFSRTVGYCQATCDPSHVVRVL
FLCACSL*VQWKEATHWSVISEAADAQGDPRKS
QVREQ*K*GGKTIL*TL*LLKFLKTPSLNNF*KK
*LNFQMSKQCHQLVFCPIEEPACSRYLN*VEKS
KHFYLHNLKNIYVYIAYSLFPLGRDDFNPNTLT
LKNFLSPRISLGL*LIFKAVLELILFPDVSRAHW
*GHTKPTVTSSGRIAAVGLLDTHIHQRCIWIWA
PPPRIPVLTCQSPD*STLLCFLSPAAPGSTHWV
QPWARHGRPCPVLPRGCVHHMSTFPSGLAASRLA
VETVPEEIRDSMNCRSIKDQAVGTRT*SDDWMS
LYCMYLVIKMPLCRKYASRGYTFLPFLKNIFVE
KIIKSPFWKLTAGFVP*QPLPM*GL*KVSCDLTQ
KRNKHTQNSFMSDSSDALPNWLVDQEFWGWGLR
RNQV*NSF*LKKYSGIQLSAVSPS*CIYCEYLL
DS*VILLIN*AKCLCAIVFPLPCKILYSINK*KN
HCFSQLFQNQGL*IL*ILFLCDVSYCFIML*LV
EILYIYFLLI*CLNF*KVLTSLSPTPLPSHEVN
S*ELSGVTGELIADHVVLQGGSPPSGPGISSQVG
FNSWALPPL**SVCLMPVRNSVWQATKFYSKKY
PATFCLFQSN*LIMQANFADSRLYL*ENKKTKV
LSAGGKDFSIENLSLTTQRLEKK*NVPLPEVLHC
SCSGLGPGRTSEWVGQVAPA*GPPQATNPLWTT
VSSWVFPHLLCNFLCFEVGLTCLQELINCTALP
TPHPYGHCIWSACFFRSMPSF*YSISFRGGWGPT
GLGVKM*KLMGALRRLHGGSMQVVLPSLLI*PG
ACVCPLTYTWGGGNVSTDDAKSVGVYSKQHCV*
EASSSSQLSNLTTFIWEFQTIEALLCFMSRFCDH
*LLYQNSSGTHL*IALIWLYTDPSLTCFLGPSV
CSICIAVSLAYLCFALMNFDRVIATLLVQYCCK
*LQIFKQSFMLIL*K*NFQLV

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATRQEPSTHEL*QINTNPKSSLPGLQ
PLSQCNGFHEAG*TCRYAPRDMDRPRVAAYWRR
V*RLLCKEVREIEEVVV*LSCIQST*GQWGSV*D
GAVEAESLKEEVREAQVFLNNYQAAEDHPRMVI
LRLLRYIVRLVWRMH*QVLCGAEIPCRHFACSN
QQDPAPRSPGAIIMQPAVLLWRGQVTFQKTPSWM
GLPFCSSPHSRISNGSLL*M*RREHSLLFNIQT
MVFWSRILCKNGVYMQCVFPLTFNKVFQKGNGN
FLTNL*ITFVLKF*EPTAYSQRIM*PLQWKLSQL
T*KAALVYF*RLQNF*TGRRVIYSLPSLLLPL*
PF*IIFNTKRVLLKWN*LKGQRVCCQPALIYQS
HL*IFTYLYKFSCICGKISDYFCVFPHHFL*CNS
SLDSDA*IWSSVFS**SEIESEQELISACILHS
SSDLLLTGKHLVLVFIPFRRACYWEVF*RGNSS
NNNRLKCYAPLCCWLFWLQAFPWSQDALSASGPR
GPPCPLQQSPAAASSSRPHGNWHRPGAGLLMAI
CLASCILVQLTVH*LHSFKFTLKQASSHFHQHH
RRIILGRSLFFFIFPGQLDIVRPLVTPAM**GCS
FSVPAPYECSGRKPHTGQSFQRQQMPRETQERV
RLGSSESEEGRQFCELCNS*NF*KLHR*TTFKR
NN*IFK*VSSATN*CFAR*KSQHVHVI*IRWKNL
NIFIFII*KIYMYILHIHFFL*VEMISIQILLL
*KISFPQESPWDFDLFLKLCWSSSCSLMCLEPI
GRVIQSPRLQAVVGLQPWACWTHTYTKDVFGSGH
PLPGSLYSRASLLTRALYSVSSALQPLGAHTGC
SPGPGTGGPALCCPGAVCTT*AHFPLAWRPPGW
LWKQFLRKLEIL*IVGVLKTRLLAPELKAMTGCL
CTVCIWLSRCLCAESMPPVGIRFYLF*KTFL*K
K*LNPLFGNLLQVLCLDNLSLCEVCKKCPVT*H
RNAINTHKIVS*VILQMPFPTG*LIKNFGGGGCG
EIKFKIPSD*KNIVEYNCLPFPLLNVYIVSIY*
IRRSYYLSTEPNVCVQLCFLYLVKFCTA*ISKK
ITVFLNFFKIKDCKYCRFFFCVMCPTVS*CCNL*
KYCIFIFCLFNVLISEKY*HPCLPLPCRPMKLT
PESCRG*LESSLQTTWSSRVALHLRVLVFPVKW
VSILGLCRPYDEVCV*CQ*ETQSGRLQNSTPRNT
QQPSVCSKATSLSCKQILLTPGFIFRKTKKPKY
YQQVGKIFLLKIYP*QLSV*KRNKMCHFQRCCI
AVVQG*GQAGQVNGWDRWLLPKDHLRPLTPCGQL
*VAGFSPTCCATSCALRLD*LVFRS*LTVQPSP
RPTHTVTAFGQPASSGRCPPSDTPSPSGEVGAP
LDWVSRCESLWEL*GDFMVVPCRWFCHPC*FSLV
PVCVHSRTRGVGETCLQMTLNQLGSTLNSIVCK
KHPQAPS*VT*LLLFGNFRL*KLSYVLCPDSVT
TSYCIRTHQVPTYK*H*SGCILIHH*PVF*DPAY
VAFVLQFPWLTCVLH**ILTG*LPLYLCNTAVN
NCRFLNNLLC*FYKNKTFN*F

Sequence BCL2L11.dAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAA
CCACTATCTCAGTGCAATGGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCGTATTGGAGACGAG
TTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCC
GCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCC
TGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCA
CACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGT
GTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTT
TGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTAT
TTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCA
AAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTA
TAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATT
TGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGA
AGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGC
CCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAG
AGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCC
AACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCT
GTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAG
TGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGG
AGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAG
CAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAA
AAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAAT
CTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTT
ACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCA
CGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCC
CTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATT
AGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCA
AGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAA
ACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAAT
AGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCT
GATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAA
CTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAA
AATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGC
TTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGG
AGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCC
TTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAA
GCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTC
TATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGC
AGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACC
TGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCAT
TTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAG
CTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACA
CGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAG
TAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCA
GGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCC
TGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTT
TATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Single exon skipping

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQDRSPAPMSCDKSTQTPSPPCQAFN
HYLSAMASMRQAEPADMRPEIWIAQELRRIGDE
FNAYYARRVFLNNYQAAEDHPRMVILRLLRYIV
RLVWRMH*QVLCGAEIPCRHFACSNQQDPAPRSP
GAIIMQPAVLLWRGQVTFQKTPSWMGLPFCSSP
HSRISNGSLL*M*RREHSLLFNIQTMVFWSRIL
CKNGVYMQCVFPLTFNKVFQKGNGNFLTNL*ITF
VLKF*EPTAYSQRIM*PLQWKLSQLT*KAALVY
F*RLQNF*TGRRVIYSLPSLLLPL*PF*IIFNT
KRVLLKWN*LKGQRVCCQPALIYQSHL*IFTYLY
KFSCICGKISDYFCVFPHHFL*CNSSLDSDA*I
WSSVFS**SEIESEQELISACILHSSSDLLLTG
KHLVLVFIPFRRACYWEVF*RGNSSNNNRLKCYA
PLCCWLFWLQAFPWSQDALSASGPRGPPCPLQQ
SPAAASSSRPHGNWHRPGAGLLMAICLASCILV
QLTVH*LHSFKFTLKQASSHFHQHHRRIILGRSL
FFFIFPGQLDIVRPLVTPAM**GCSFSVPAPYE
CSGRKPHTGQSFQRQQMPRETQERVRLGSSESE
EGRQFCELCNS*NF*KLHR*TTFKRNN*IFK*VS
SATN*CFAR*KSQHVHVI*IRWKNLNIFIFII*
KIYMYILHIHFFL*VEMISIQILLL*KISFPQE
SPWDFDLFLKLCWSSSCSLMCLEPIGRVIQSPRL
QAVVGLQPWACWTHTYTKDVFGSGHPLPGSLYS
RASLLTRALYSVSSALQPLGAHTGCSPGPGTGG
PALCCPGAVCTT*AHFPLAWRPPGWLWKQFLRKL
EIL*IVGVLKTRLLAPELKAMTGCLCTVCIWLS
RCLCAESMPPVGIRFYLF*KTFL*KK*LNPLFG
NLLQVLCLDNLSLCEVCKKCPVT*HRNAINTHKI
VS*VILQMPFPTG*LIKNFGGGGCGEIKFKIPS
D*KNIVEYNCLPFPLLNVYIVSIY*IRRSYYLS
TEPNVCVQLCFLYLVKFCTA*ISKKITVFLNFFK
IKDCKYCRFFFCVMCPTVS*CCNL*KYCIFIFC
LFNVLISEKY*HPCLPLPCRPMKLTPESCRG*L
ESSLQTTWSSRVALHLRVLVFPVKWVSILGLCRP
YDEVCV*CQ*ETQSGRLQNSTPRNTQQPSVCSK
ATSLSCKQILLTPGFIFRKTKKPKYYQQVGKIF
LLKIYP*QLSV*KRNKMCHFQRCCIAVVQG*GQA
GQVNGWDRWLLPKDHLRPLTPCGQL*VAGFSPT
CCATSCALRLD*LVFRS*LTVQPSPRPTHTVTA
FGQPASSGRCPPSDTPSPSGEVGAPLDWVSRCES
LWEL*GDFMVVPCRWFCHPC*FSLVPVCVHSRT
RGVGETCLQMTLNQLGSTLNSIVCKKHPQAPS*
VT*LLLFGNFRL*KLSYVLCPDSVTTSYCIRTHQ
VPTYK*H*SGCILIHH*PVF*DPAYVAFVLQFP
WLTCVLH**ILTG*LPLYLCNTAVNNCRFLNNL
LC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKTGAQHP*VVTNQHKPQVLLARPS
TTISVQWLP*GRLNLQICAQRYGSPKSCGVLETS
LTLTMQGGYF*IITKQPKTTHEWLSYDCYVTLS
AWCGECIDRFFAEPRYHADILLVQTNKTQHRGL
LVPLLCSQRFSCGGGR*RFRRHRAGWDYLSVHHH
TAEFLMEVCCECKGGSILCFLIYKPWFFGAGFC
VRMVFTCSVFSPSPSIRFFKKEMETF*PICE*L
LY*NFKNLRPILRGLCNPCSGN*AS*LKKLP*FI
FRDYRIFKQGDV*YTPSLPYYCLSDLFKLFLIP
KEFF*NGTD*KGRGSVASLH*YTSPICKYLRTF
INSVASVAKFQTIFASFLITFCDATPVWTQMHRF
GPVYFHDKVKLSQNKS*YLPVSCTVRAICY*LG
SIWCWFSFHFDEHVIGKYSEEAIAVITTDLSAT
PLCAAGFSGCRLSHGHRMHCQHQVPEGHRVHYSR
VQLQHPAHALMGIGTGLGQGF*WPFAWPPAF*S
NSQSTSFTPLNSL*NRPHPTSTSTIEE*FWAEV
CFFSFFQDSWILSGHL*PQPCSEGALSLCLLLMS
AVEGSHTLVSHFRGSRCPGRPKKESG*GAVKVR
REDNSVNSVTLKIFENSIVKQLLKEITKFSNE*
AVPPTSVLPDRRASMFTLFKLGGKI*TFLSS*FK
KYICIYCIFTFSFR*R*FQSKYSYFKKFPFPKN
LLGTLTYF*SCVGAHLVP*CVSSPLVGSYKAHG
YKQW*DCSRGPAGHTHTPKMYLDLGTPSQDPCTH
VPVS*LEHFTLFPQPCSPWEHTLGAALGQAREA
LPCAAQGLCAPHEHISLWPGGLQAGCGNSS*GN
*RFYEL*EY*RPGCWHQNLKR*LDVSVLYVSGYQ
DASVQKVCLPWVYVFTFFKKHFCRKNN*IPFLE
TYCRFCALTTSPYVRFVKSVL*LNTETQ*THTK
*FHE*FFRCPSQLVS*SRILGVGVAEKSSLKFLL
IKKI*WNTIVCRFPFLMYIL*VFIRFVGHITYQ
LSQMSVCNCVSFTL*NFVQHK*VKKSLFFSTFS
KSRIVNIVDSFSV*CVLLFHNAVTCRNIVYLFSA
YLMS*FLKSINIPVSHSPAVP*S*LLRVVGGDW
RAHCRPRGPPGWLSTFGSWYFQSSGFQFLGFAA
LMMKCVFDASEKLSLAGYKILLQEIPSNLLFVPK
QLAYHASKFC*LQALSLGKQKNQSIISRWERFF
Y*KFIPDNSAFRKEIKCATSRGAALQLFRARAR
QDK*MGGTGGSCLRTTSGH*PLVDNCE*LGFPPP
AVQLPVL*GWTNLSSGAN*LYSPPHAPPIRSLH
LVSLLLQVDALLLILHLLQGRLGPHWTGCQDVK
AYGSFKETSWWFHAGGSAIPADLAWCLCVSTHVH
VGWGKRVYR*R*ISWGLL*TALCVRSILKLPVK
*LDYFYLGISDYRSSLMFYVQIL*PLVTVSELI
RYPLINSTDLAVY*SITNLFSRTQRM*HLYCSFP
GLLVFCTDEF*QGNCHFTCAILL*ITADF*TIF
YVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATRQEPSTHEL*QINTNPKSSLPGLQ
PLSQCNGFHEAG*TCRYAPRDMDRPRVAAYWRR
V*RLLCKEGIFE*LPSSRRPPTNGYLTTVTLHCP
PGVENALTGSLRSRDTMQTFCLFKPTRPSTAVS
WCHYYAASGSLVEGAGDVSEDTELDGTTFLFIT
TQQNF*WKFVVNVKEGAFFAF*YTNHGFLEQDFV
*EWCLHAVCFPPHLQ*GFSKRKWKLFNQFVNNF
CIKILRTYGLFSEDYVTPAVETEPANLKSCLSL
FLEITEFLNRETCDILPPFPTIASLTFLNYF*YQ
KSSFEMELIKRAEGLLPACIDIPVPFVNIYVPL
*IQLHLWQNFRLFLRLSSSLFVMQLQSGLRCID
LVQCIFMIK*N*VRTRVNICLYLAQFERSVINWE
AFGVGFHSISTSMLLGSILKRQ*Q**QQT*VLR
PFVLLAFLVAGFPMVTGCTVSIRSQRATVSITA
ESSCSIQLTPSWELAQAWGRASDGHLLGLLHFSP
THSPLASLL*IHFETGLIPLPPAP*KNNSGQKS
VFFHFSRTVGYCQATCDPSHVVRVLFLCACSL*
VQWKEATHWSVISEAADAQGDPRKSQVREQ*K*G
GKTIL*TL*LLKFLKTPSLNNF*KK*LNFQMSK
QCHQLVFCPIEEPACSRYLN*VEKSKHFYLHNL
KNIYVYIAYSLFPLGRDDFNPNTLTLKNFLSPRI
SLGL*LIFKAVLELILFPDVSRAHW*GHTKPTV
TSSGRIAAVGLLDTHIHQRCIWIWAPPPRIPVL
TCQSPD*STLLCFLSPAAPGSTHWVQPWARHGRP
CPVLPRGCVHHMSTFPSGLAASRLAVETVPEEI
RDSMNCRSIKDQAVGTRT*SDDWMSLYCMYLVI
KMPLCRKYASRGYTFLPFLKNIFVEKIIKSPFWK
LTAGFVP*QPLPM*GL*KVSCDLTQKRNKHTQN
SFMSDSSDALPNWLVDQEFWGWGLRRNQV*NSF
*LKKYSGIQLSAVSPS*CIYCEYLLDS*VILLIN
*AKCLCAIVFPLPCKILYSINK*KNHCFSQLFQ
NQGL*IL*ILFLCDVSYCFIML*LVEILYIYFL
LI*CLNF*KVLTSLSPTPLPSHEVNS*ELSGVTG
ELIADHVVLQGGSPPSGPGISSQVGFNSWALPP
L**SVCLMPVRNSVWQATKFYSKKYPATFCLFQ
SN*LIMQANFADSRLYL*ENKKTKVLSAGGKDFS
IENLSLTTQRLEKK*NVPLPEVLHCSCSGLGPG
RTSEWVGQVAPA*GPPQATNPLWTTVSSWVFPH
LLCNFLCFEVGLTCLQELINCTALPTPHPYGHCI
WSACFFRSMPSF*YSISFRGGWGPTGLGVKM*K
LMGALRRLHGGSMQVVLPSLLI*PGACVCPLTY
TWGGGNVSTDDAKSVGVYSKQHCV*EASSSSQLS
NLTTFIWEFQTIEALLCFMSRFCDH*LLYQNSS
GTHL*IALIWLYTDPSLTCFLGPSVCSICIAVS
LAYLCFALMNFDRVIATLLVQYCCK*LQIFKQSF
MLIL*K*NFQLV

Sequence BCL2L11.qAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTAACTGGGACTAGAAACAGCTCCATCACCCAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCG
TATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGATGCCTCTTCCACCTGATTAAGAACCACTGTAGCAGACGCAGACTTATTGGACACTAGGCGGG
AGGCCAGCTCTGCAGACAGCAGGTCTCAGGAAGACGGTCAAGGCATGGCTGCTGATGATCCGCTTATGGGTATTTTTGAATAATTACCAAGCAGCCGAAG
ACCACCCACGAATGGTTATCTTACGACTGTTACGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAG
ACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTT
CAGAAGACACCGAGCTGGATGGGACTACCTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTT
TGCTTTTTAATATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTT
TCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTG
CAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTT
CCCTACTATTGCCTCTCTGACCTTTTTAAATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCC
TGCATTGATATACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCAT
CACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATAT
CTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATT
CTGAAGAGGCAATAGCAGTAATAACAACAGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCA
CTGTCAGCATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGG
CAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATC
CCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCA
GCCATGTAGTGAGGGTGCTCTTTCTCTGTGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCA
GGGAGACCCAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCG
TTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATT
TAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTT
CAATCCAAATACTCTTACTTTAAAAAATTTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCT
GATGTGTCTCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAA
GATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCC
TGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGC
CTGGCGGCCTCCAGGCTGGCTGTGGAAACAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTT
AAAGCGATGACTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTT
AAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAA
GTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAAT
TTTGGGGGTGGGGGTTGCGGAGAAATCAAGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTAT
ATATTGTGAGTATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTAC
AGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTT
TCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCT
GCCGTCCCATGAAGTTAACTCCTGAGAGTTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCT
GGTATTTCCAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAA
AATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGA
AAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCA
CTTCCAGAGGTGCTGCATTGCAGTTGTTCAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCA
CTAACCCCTTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAAT
TAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTC
AGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCAT
CCCTGCTGATTTAGCCTGGTGCCTGTGTGTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTC
TAAACAGCATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTT
ATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCT
GTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACT
TGTGCAATACTGCTGTAAATAACTGCAGATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Single exon skipping

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ANWD*KQLHHPASMRQAEPADMRPEIWIAQELRR
IGDEFNAYYARRMPLPPD*EPL*QTQTYWTLGG
RPALQTAGLRKTVKAWLLMIRLWVFLNNYQAAE
DHPRMVILRLLRYIVRLVWRMH*QVLCGAEIPCR
HFACSNQQDPAPRSPGAIIMQPAVLLWRGQVTF
QKTPSWMGLPFCSSPHSRISNGSLL*M*RREHS
LLFNIQTMVFWSRILCKNGVYMQCVFPLTFNKVF
QKGNGNFLTNL*ITFVLKF*EPTAYSQRIM*PL
QWKLSQLT*KAALVYF*RLQNF*TGRRVIYSLP
SLLLPL*PF*IIFNTKRVLLKWN*LKGQRVCCQP
ALIYQSHL*IFTYLYKFSCICGKISDYFCVFPH
HFL*CNSSLDSDA*IWSSVFS**SEIESEQELI
SACILHSSSDLLLTGKHLVLVFIPFRRACYWEVF
*RGNSSNNNRLKCYAPLCCWLFWLQAFPWSQDA
LSASGPRGPPCPLQQSPAAASSSRPHGNWHRPG
AGLLMAICLASCILVQLTVH*LHSFKFTLKQASS
HFHQHHRRIILGRSLFFFIFPGQLDIVRPLVTP
AM**GCSFSVPAPYECSGRKPHTGQSFQRQQMP
RETQERVRLGSSESEEGRQFCELCNS*NF*KLHR
*TTFKRNN*IFK*VSSATN*CFAR*KSQHVHVI
*IRWKNLNIFIFII*KIYMYILHIHFFL*VEMI
SIQILLL*KISFPQESPWDFDLFLKLCWSSSCSL
MCLEPIGRVIQSPRLQAVVGLQPWACWTHTYTK
DVFGSGHPLPGSLYSRASLLTRALYSVSSALQP
LGAHTGCSPGPGTGGPALCCPGAVCTT*AHFPLA
WRPPGWLWKQFLRKLEIL*IVGVLKTRLLAPEL
KAMTGCLCTVCIWLSRCLCAESMPPVGIRFYLF
*KTFL*KK*LNPLFGNLLQVLCLDNLSLCEVCKK
CPVT*HRNAINTHKIVS*VILQMPFPTG*LIKN
FGGGGCGEIKFKIPSD*KNIVEYNCLPFPLLNV
YIVSIY*IRRSYYLSTEPNVCVQLCFLYLVKFCT
A*ISKKITVFLNFFKIKDCKYCRFFFCVMCPTV
S*CCNL*KYCIFIFCLFNVLISEKY*HPCLPLP
CRPMKLTPESCRG*LESSLQTTWSSRVALHLRVL
VFPVKWVSILGLCRPYDEVCV*CQ*ETQSGRLQ
NSTPRNTQQPSVCSKATSLSCKQILLTPGFIFR
KTKKPKYYQQVGKIFLLKIYP*QLSV*KRNKMCH
FQRCCIAVVQG*GQAGQVNGWDRWLLPKDHLRP
LTPCGQL*VAGFSPTCCATSCALRLD*LVFRS*
LTVQPSPRPTHTVTAFGQPASSGRCPPSDTPSPS
GEVGAPLDWVSRCESLWEL*GDFMVVPCRWFCH
PC*FSLVPVCVHSRTRGVGETCLQMTLNQLGST
LNSIVCKKHPQAPS*VT*LLLFGNFRL*KLSYVL
CPDSVTTSYCIRTHQVPTYK*H*SGCILIHH*P
VF*DPAYVAFVLQFPWLTCVLH**ILTG*LPLY
LCNTAVNNCRFLNNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LTGTRNSSITQLP*GRLNLQICAQRYGSPKSCG
VLETSLTLTMQGGCLFHLIKNHCSRRRLIGH*AG
GQLCRQQVSGRRSRHGC**SAYGYF*IITKQPK
TTHEWLSYDCYVTLSAWCGECIDRFFAEPRYHA
DILLVQTNKTQHRGLLVPLLCSQRFSCGGGR*RF
RRHRAGWDYLSVHHHTAEFLMEVCCECKGGSIL
CFLIYKPWFFGAGFCVRMVFTCSVFSPSPSIRF
FKKEMETF*PICE*LLY*NFKNLRPILRGLCNPC
SGN*AS*LKKLP*FIFRDYRIFKQGDV*YTPSL
PYYCLSDLFKLFLIPKEFF*NGTD*KGRGSVAS
LH*YTSPICKYLRTFINSVASVAKFQTIFASFLI
TFCDATPVWTQMHRFGPVYFHDKVKLSQNKS*Y
LPVSCTVRAICY*LGSIWCWFSFHFDEHVIGKY
SEEAIAVITTDLSATPLCAAGFSGCRLSHGHRMH
CQHQVPEGHRVHYSRVQLQHPAHALMGIGTGLG
QGF*WPFAWPPAF*SNSQSTSFTPLNSL*NRPH
PTSTSTIEE*FWAEVCFFSFFQDSWILSGHL*PQ
PCSEGALSLCLLLMSAVEGSHTLVSHFRGSRCP
GRPKKESG*GAVKVRREDNSVNSVTLKIFENSI
VKQLLKEITKFSNE*AVPPTSVLPDRRASMFTLF
KLGGKI*TFLSS*FKKYICIYCIFTFSFR*R*F
QSKYSYFKKFPFPKNLLGTLTYF*SCVGAHLVP
*CVSSPLVGSYKAHGYKQW*DCSRGPAGHTHTPK
MYLDLGTPSQDPCTHVPVS*LEHFTLFPQPCSP
WEHTLGAALGQAREALPCAAQGLCAPHEHISLW
PGGLQAGCGNSS*GN*RFYEL*EY*RPGCWHQNL
KR*LDVSVLYVSGYQDASVQKVCLPWVYVFTFF
KKHFCRKNN*IPFLETYCRFCALTTSPYVRFVK
SVL*LNTETQ*THTK*FHE*FFRCPSQLVS*SRI
LGVGVAEKSSLKFLLIKKI*WNTIVCRFPFLMY
IL*VFIRFVGHITYQLSQMSVCNCVSFTL*NFV
QHK*VKKSLFFSTFSKSRIVNIVDSFSV*CVLLF
HNAVTCRNIVYLFSAYLMS*FLKSINIPVSHSP
AVP*S*LLRVVGGDWRAHCRPRGPPGWLSTFGS
WYFQSSGFQFLGFAALMMKCVFDASEKLSLAGYK
ILLQEIPSNLLFVPKQLAYHASKFC*LQALSLG
KQKNQSIISRWERFFY*KFIPDNSAFRKEIKCA
TSRGAALQLFRARARQDK*MGGTGGSCLRTTSGH
*PLVDNCE*LGFPPPAVQLPVL*GWTNLSSGAN
*LYSPPHAPPIRSLHLVSLLLQVDALLLILHLL
QGRLGPHWTGCQDVKAYGSFKETSWWFHAGGSAI
PADLAWCLCVSTHVHVGWGKRVYR*R*ISWGLL
*TALCVRSILKLPVK*LDYFYLGISDYRSSLMF
YVQIL*PLVTVSELIRYPLINSTDLAVY*SITNL
FSRTQRM*HLYCSFPGLLVFCTDEF*QGNCHFT
CAILL*ITADF*TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
*LGLETAPSPSFHEAG*TCRYAPRDMDRPRVAA
YWRRV*RLLCKEDASST*LRTTVADADLLDTRR
EASSADSRSQEDGQGMAADDPLMGIFE*LPSSRR
PPTNGYLTTVTLHCPPGVENALTGSLRSRDTMQ
TFCLFKPTRPSTAVSWCHYYAASGSLVEGAGDV
SEDTELDGTTFLFITTQQNF*WKFVVNVKEGAFF
AF*YTNHGFLEQDFV*EWCLHAVCFPPHLQ*GF
SKRKWKLFNQFVNNFCIKILRTYGLFSEDYVTP
AVETEPANLKSCLSLFLEITEFLNRETCDILPPF
PTIASLTFLNYF*YQKSSFEMELIKRAEGLLPA
CIDIPVPFVNIYVPL*IQLHLWQNFRLFLRLSS
SLFVMQLQSGLRCIDLVQCIFMIK*N*VRTRVNI
CLYLAQFERSVINWEAFGVGFHSISTSMLLGSI
LKRQ*Q**QQT*VLRPFVLLAFLVAGFPMVTGC
TVSIRSQRATVSITAESSCSIQLTPSWELAQAWG
RASDGHLLGLLHFSPTHSPLASLL*IHFETGLI
PLPPAP*KNNSGQKSVFFHFSRTVGYCQATCDP
SHVVRVLFLCACSL*VQWKEATHWSVISEAADAQ
GDPRKSQVREQ*K*GGKTIL*TL*LLKFLKTPS
LNNF*KK*LNFQMSKQCHQLVFCPIEEPACSRY
LN*VEKSKHFYLHNLKNIYVYIAYSLFPLGRDDF
NPNTLTLKNFLSPRISLGL*LIFKAVLELILFP
DVSRAHW*GHTKPTVTSSGRIAAVGLLDTHIHQ
RCIWIWAPPPRIPVLTCQSPD*STLLCFLSPAAP
GSTHWVQPWARHGRPCPVLPRGCVHHMSTFPSG
LAASRLAVETVPEEIRDSMNCRSIKDQAVGTRT
*SDDWMSLYCMYLVIKMPLCRKYASRGYTFLPFL
KNIFVEKIIKSPFWKLTAGFVP*QPLPM*GL*K
VSCDLTQKRNKHTQNSFMSDSSDALPNWLVDQE
FWGWGLRRNQV*NSF*LKKYSGIQLSAVSPS*CI
YCEYLLDS*VILLIN*AKCLCAIVFPLPCKILY
SINK*KNHCFSQLFQNQGL*IL*ILFLCDVSYC
FIML*LVEILYIYFLLI*CLNF*KVLTSLSPTPL
PSHEVNS*ELSGVTGELIADHVVLQGGSPPSGP
GISSQVGFNSWALPPL**SVCLMPVRNSVWQAT
KFYSKKYPATFCLFQSN*LIMQANFADSRLYL*E
NKKTKVLSAGGKDFSIENLSLTTQRLEKK*NVP
LPEVLHCSCSGLGPGRTSEWVGQVAPA*GPPQA
TNPLWTTVSSWVFPHLLCNFLCFEVGLTCLQELI
NCTALPTPHPYGHCIWSACFFRSMPSF*YSISF
RGGWGPTGLGVKM*KLMGALRRLHGGSMQVVLP
SLLI*PGACVCPLTYTWGGGNVSTDDAKSVGVYS
KQHCV*EASSSSQLSNLTTFIWEFQTIEALLCF
MSRFCDH*LLYQNSSGTHL*IALIWLYTDPSLT
CFLGPSVCSICIAVSLAYLCFALMNFDRVIATLL
VQYCCK*LQIFKQSFMLIL*K*NFQLV

Sequence BCL2L11.fAug05

GACCAAATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGAGGCCTCCCCAGCTCAGACCTGGGG
CCCCTACCTCCCTACAGACAGAGCCACAAGGTAATCCTGAAGGCAATCACGGAGGTGAAGGGGACAGCTGCCCCCACGGCAGCCCTCAGGGCCCGCTGGC
CCCACCTGCCAGCCCTGGCCCTTTTGCTACCAGATCCCCGCTTTTCATCTTTATGAGAAGATCCTCCCTGCTGTCTCGATCCTCCAGTGGGTATTTCTCT
TTTGACACAGACAGGAGCCCAGCACCCATGAGTTGTGACAAATCAACACAAACCCCAAGTCCTCCTTGCCAGGCCTTCAACCACTATCTCAGTGCAATGG
CTAACTGGGACTAGAAACAGCTCCATCACCCAGCTTCCATGAGGCAGGCTGAACCTGCAGATATGCGCCCAGAGATATGGATCGCCCAAGAGTTGCGGCG
TATTGGAGACGAGTTTAACGCTTACTATGCAAGGAGGGTATTTTTGAATAATTACCAAGCAGCCGAAGACCACCCACGAATGGTTATCTTACGACTGTTA
CGTTACATTGTCCGCCTGGTGTGGAGAATGCATTGACAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAG
CACCGCGGTCTCCTGGTGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTACCTTT
CTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTTAATATACAAACCATGGTTTTTTGG
AGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTTCAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATT
TGTGAATAACTTTTGTATTAAAATTTTAAGAACCTACGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGC
TGCCTTAGTTTATTTTTAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTAAATT
ATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGATATACCAGTCCCATTTGTAAATAT
TTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGCGTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTC
AGATGCATAGATTTGGTCCAGTGTATTTTCATGATAAAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTG
TTATTAACTGGGAAGCATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAACAGAC
TTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGCATCAGGTCCCAGAGGGCCACCGTG
TCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGCACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCC
TGCATTTTAGTCCAACTCACAGTCCACTAGCTTCACTCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTC
TGGGCAGAAGTCTGTTTTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTGTGCC
TGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACCCAAGAAAGAGTCAGGTTAGGGAGC
AGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTGAAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTT
TCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTGCCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTAT
CTTCATAATTTAAAAAATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAATTTCC
TTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTCTCGAGCCCATTGGTAGGGTCATAC
AAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACACACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGG
ATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGCACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCA
GGCACGGGAGGCCCTGCCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAACAGT
TCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGATGACTGGATGTCTCTGTACTGTATG
TATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTTTTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAAT
CCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTTGACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAA
ACACACACAAAATAGTTTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCAAGTT
TAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTGAGTATTTATTAGATTCGTAGGTCA
TATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGTAAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTC
TCAACTTTTTCAAAATCAAGGATTGTAAATATTGTAGATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTAT
ATTTATTTTCTGCTTATTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAGTTGT
CGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTCCAGTCAAGTGGGTTTCAATTCTTG
GGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCTGGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTC
TGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCAAATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTG
GGAAAGATTTTTCTATTGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTTCAGG
GCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCCTTGTGGACAACTGTGAGTAGCTGG
GTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCTTCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCAT
ACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGTCGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGT
CAAGATGTGAAAGCTTATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGTGTGT
CCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGCATTGTGTGTAAGAAGCATCCTCAA
GCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCTCTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTA
TCAGAACTCATCAGGTACCCACTTATAAATAGCACTGATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGT
ATTGCAGTTTCCCTGGCTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAGATTT
TTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTTT
  • 113317 (forward primer)
  • BCL2L11-4 (reverse primer)
  • Single exon skipping

Frame 0

DQMAKQPSDVSSECDREGRQLQPAERPPQLRPG
APTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLA
PPASPGPFATRSPLFIFMRRSSLLSRSSSGYFS
FDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAM
ANWD*KQLHHPASMRQAEPADMRPEIWIAQELRR
IGDEFNAYYARRVFLNNYQAAEDHPRMVILRLL
RYIVRLVWRMH*QVLCGAEIPCRHFACSNQQDP
APRSPGAIIMQPAVLLWRGQVTFQKTPSWMGLPF
CSSPHSRISNGSLL*M*RREHSLLFNIQTMVFW
SRILCKNGVYMQCVFPLTFNKVFQKGNGNFLTN
L*ITFVLKF*EPTAYSQRIM*PLQWKLSQLT*KA
ALVYF*RLQNF*TGRRVIYSLPSLLLPL*PF*I
IFNTKRVLLKWN*LKGQRVCCQPALIYQSHL*I
FTYLYKFSCICGKISDYFCVFPHHFL*CNSSLDS
DA*IWSSVFS**SEIESEQELISACILHSSSDL
LLTGKHLVLVFIPFRRACYWEVF*RGNSSNNNR
LKCYAPLCCWLFWLQAFPWSQDALSASGPRGPPC
PLQQSPAAASSSRPHGNWHRPGAGLLMAICLAS
CILVQLTVH*LHSFKFTLKQASSHFHQHHRRII
LGRSLFFFIFPGQLDIVRPLVTPAM**GCSFSVP
APYECSGRKPHTGQSFQRQQMPRETQERVRLGS
SESEEGRQFCELCNS*NF*KLHR*TTFKRNN*I
FK*VSSATN*CFAR*KSQHVHVI*IRWKNLNIFI
FII*KIYMYILHIHFFL*VEMISIQILLL*KIS
FPQESPWDFDLFLKLCWSSSCSLMCLEPIGRVI
QSPRLQAVVGLQPWACWTHTYTKDVFGSGHPLPG
SLYSRASLLTRALYSVSSALQPLGAHTGCSPGP
GTGGPALCCPGAVCTT*AHFPLAWRPPGWLWKQ
FLRKLEIL*IVGVLKTRLLAPELKAMTGCLCTVC
IWLSRCLCAESMPPVGIRFYLF*KTFL*KK*LN
PLFGNLLQVLCLDNLSLCEVCKKCPVT*HRNAI
NTHKIVS*VILQMPFPTG*LIKNFGGGGCGEIKF
KIPSD*KNIVEYNCLPFPLLNVYIVSIY*IRRS
YYLSTEPNVCVQLCFLYLVKFCTA*ISKKITVF
LNFFKIKDCKYCRFFFCVMCPTVS*CCNL*KYCI
FIFCLFNVLISEKY*HPCLPLPCRPMKLTPESC
RG*LESSLQTTWSSRVALHLRVLVFPVKWVSIL
GLCRPYDEVCV*CQ*ETQSGRLQNSTPRNTQQPS
VCSKATSLSCKQILLTPGFIFRKTKKPKYYQQV
GKIFLLKIYP*QLSV*KRNKMCHFQRCCIAVVQ
G*GQAGQVNGWDRWLLPKDHLRPLTPCGQL*VAG
FSPTCCATSCALRLD*LVFRS*LTVQPSPRPTH
TVTAFGQPASSGRCPPSDTPSPSGEVGAPLDWV
SRCESLWEL*GDFMVVPCRWFCHPC*FSLVPVCV
HSRTRGVGETCLQMTLNQLGSTLNSIVCKKHPQ
APS*VT*LLLFGNFRL*KLSYVLCPDSVTTSYC
IRTHQVPTYK*H*SGCILIHH*PVF*DPAYVAFV
LQFPWLTCVLH**ILTG*LPLYLCNTAVNNCRF
LNNLLC*FYKNKTFN*F

Frame 1

TKWQSNLLM*VLSVTEKVDNCSLRRGLPSSDLG
PLPPYRQSHKVILKAITEVKGTAAPTAALRARW
PHLPALALLLPDPRFSSL*EDPPCCLDPPVGISL
LTQTGAQHP*VVTNQHKPQVLLARPSTTISVQW
LTGTRNSSITQLP*GRLNLQICAQRYGSPKSCG
VLETSLTLTMQGGYF*IITKQPKTTHEWLSYDCY
VTLSAWCGECIDRFFAEPRYHADILLVQTNKTQ
HRGLLVPLLCSQRFSCGGGR*RFRRHRAGWDYL
SVHHHTAEFLMEVCCECKGGSILCFLIYKPWFFG
AGFCVRMVFTCSVFSPSPSIRFFKKEMETF*PI
CE*LLY*NFKNLRPILRGLCNPCSGN*AS*LKK
LP*FIFRDYRIFKQGDV*YTPSLPYYCLSDLFKL
FLIPKEFF*NGTD*KGRGSVASLH*YTSPICKY
LRTFINSVASVAKFQTIFASFLITFCDATPVWT
QMHRFGPVYFHDKVKLSQNKS*YLPVSCTVRAIC
Y*LGSIWCWFSFHFDEHVIGKYSEEAIAVITTD
LSATPLCAAGFSGCRLSHGHRMHCQHQVPEGHR
VHYSRVQLQHPAHALMGIGTGLGQGF*WPFAWPP
AF*SNSQSTSFTPLNSL*NRPHPTSTSTIEE*F
WAEVCFFSFFQDSWILSGHL*PQPCSEGALSLC
LLLMSAVEGSHTLVSHFRGSRCPGRPKKESG*GA
VKVRREDNSVNSVTLKIFENSIVKQLLKEITKF
SNE*AVPPTSVLPDRRASMFTLFKLGGKI*TFL
SS*FKKYICIYCIFTFSFR*R*FQSKYSYFKKFP
FPKNLLGTLTYF*SCVGAHLVP*CVSSPLVGSY
KAHGYKQW*DCSRGPAGHTHTPKMYLDLGTPSQ
DPCTHVPVS*LEHFTLFPQPCSPWEHTLGAALGQ
AREALPCAAQGLCAPHEHISLWPGGLQAGCGNS
S*GN*RFYEL*EY*RPGCWHQNLKR*LDVSVLY
VSGYQDASVQKVCLPWVYVFTFFKKHFCRKNN*I
PFLETYCRFCALTTSPYVRFVKSVL*LNTETQ*
THTK*FHE*FFRCPSQLVS*SRILGVGVAEKSS
LKFLLIKKI*WNTIVCRFPFLMYIL*VFIRFVGH
ITYQLSQMSVCNCVSFTL*NFVQHK*VKKSLFF
STFSKSRIVNIVDSFSV*CVLLFHNAVTCRNIV
YLFSAYLMS*FLKSINIPVSHSPAVP*S*LLRVV
GGDWRAHCRPRGPPGWLSTFGSWYFQSSGFQFL
GFAALMMKCVFDASEKLSLAGYKILLQEIPSNL
LFVPKQLAYHASKFC*LQALSLGKQKNQSIISRW
ERFFY*KFIPDNSAFRKEIKCATSRGAALQLFR
ARARQDK*MGGTGGSCLRTTSGH*PLVDNCE*L
GFPPPAVQLPVL*GWTNLSSGAN*LYSPPHAPPI
RSLHLVSLLLQVDALLLILHLLQGRLGPHWTGC
QDVKAYGSFKETSWWFHAGGSAIPADLAWCLCV
STHVHVGWGKRVYR*R*ISWGLL*TALCVRSILK
LPVK*LDYFYLGISDYRSSLMFYVQIL*PLVTV
SELIRYPLINSTDLAVY*SITNLFSRTQRM*HL
YCSFPGLLVFCTDEF*QGNCHFTCAILL*ITADF
*TIFYVNFIKIKLSTSF

Frame 2

PNGKATF*CKF*V*PRR*TIAACGEASPAQTWG
PYLPTDRATR*S*RQSRR*RGQLPPRQPSGPAG
PTCQPWPFCYQIPAFHLYEKILPAVSILQWVFL
F*HRQEPSTHEL*QINTNPKSSLPGLQPLSQCNG
*LGLETAPSPSFHEAG*TCRYAPRDMDRPRVAA
YWRRV*RLLCKEGIFE*LPSSRRPPTNGYLTTV
TLHCPPGVENALTGSLRSRDTMQTFCLFKPTRPS
TAVSWCHYYAASGSLVEGAGDVSEDTELDGTTF
LFITTQQNF*WKFVVNVKEGAFFAF*YTNHGFL
EQDFV*EWCLHAVCFPPHLQ*GFSKRKWKLFNQF
VNNFCIKILRTYGLFSEDYVTPAVETEPANLKS
CLSLFLEITEFLNRETCDILPPFPTIASLTFLN
YF*YQKSSFEMELIKRAEGLLPACIDIPVPFVNI
YVPL*IQLHLWQNFRLFLRLSSSLFVMQLQSGL
RCIDLVQCIFMIK*N*VRTRVNICLYLAQFERS
VINWEAFGVGFHSISTSMLLGSILKRQ*Q**QQT
*VLRPFVLLAFLVAGFPMVTGCTVSIRSQRATV
SITAESSCSIQLTPSWELAQAWGRASDGHLLGL
LHFSPTHSPLASLL*IHFETGLIPLPPAP*KNNS
GQKSVFFHFSRTVGYCQATCDPSHVVRVLFLCA
CSL*VQWKEATHWSVISEAADAQGDPRKSQVRE
Q*K*GGKTIL*TL*LLKFLKTPSLNNF*KK*LNF
QMSKQCHQLVFCPIEEPACSRYLN*VEKSKHFY
LHNLKNIYVYIAYSLFPLGRDDFNPNTLTLKNF
LSPRISLGL*LIFKAVLELILFPDVSRAHW*GHT
KPTVTSSGRIAAVGLLDTHIHQRCIWIWAPPPR
IPVLTCQSPD*STLLCFLSPAAPGSTHWVQPWA
RHGRPCPVLPRGCVHHMSTFPSGLAASRLAVETV
PEEIRDSMNCRSIKDQAVGTRT*SDDWMSLYCM
YLVIKMPLCRKYASRGYTFLPFLKNIFVEKIIK
SPFWKLTAGFVP*QPLPM*GL*KVSCDLTQKRNK
HTQNSFMSDSSDALPNWLVDQEFWGWGLRRNQV
*NSF*LKKYSGIQLSAVSPS*CIYCEYLLDS*V
ILLIN*AKCLCAIVFPLPCKILYSINK*KNHCFS
QLFQNQGL*IL*ILFLCDVSYCFIML*LVEILY
IYFLLI*CLNF*KVLTSLSPTPLPSHEVNS*EL
SGVTGELIADHVVLQGGSPPSGPGISSQVGFNSW
ALPPL**SVCLMPVRNSVWQATKFYSKKYPATF
CLFQSN*LIMQANFADSRLYL*ENKKTKVLSAG
GKDFSIENLSLTTQRLEKK*NVPLPEVLHCSCSG
LGPGRTSEWVGQVAPA*GPPQATNPLWTTVSSW
VFPHLLCNFLCFEVGLTCLQELINCTALPTPHP
YGHCIWSACFFRSMPSF*YSISFRGGWGPTGLGV
KM*KLMGALRRLHGGSMQVVLPSLLI*PGACVC
PLTYTWGGGNVSTDDAKSVGVYSKQHCV*EASS
SSQLSNLTTFIWEFQTIEALLCFMSRFCDH*LLY
QNSSGTHL*IALIWLYTDPSLTCFLGPSVCSIC
IAVSLAYLCFALMNFDRVIATLLVQYCCK*LQI
FKQSFMLIL*K*NFQLV

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