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Sequences

Sequence BCL2L12.dAug05

CTCCTGCTGTGCATCCTGCCGTAGGCCGTGCTTCCAAGGGATGCGGAAGCGCGTGCGGCTCTTGTTCACCCAGGCCACGCCCTCCAGTTGCCCCAGGTCC
AGCTGCGACACCAGCCAGGGCAGGATCCGTGGCTTTGGGGTTCCCATGGTCCGGCCTGCGCGTATAGGGCATTTCCTGGGCGCGACCGGCCTCCCCCGGA
CCCACCTGGCCTGGAGTTTCCGCACCCAGACCTCCTTCTCACGGGCCACGGCACAGGTCCTTCACCCATATTTTCGGGGGTACAAACAGGAAACCTCCTC
TTCCCATCCTCCCATCCTCCCGAGAGGCTCTCTAATCAGCTAGGGTTCCTTCCCATATCCATGGCACATCCTTCCCCAGCGTCTTCAGTGCAGACCCTCC
ACTCCCTCAATTCCGCCAGTATAGACCTCCTCCCTCCCCCACATCATCGAAAGTAAGTATCCCCACTTTCAGGGTAGCATCCTCTTTCCCTAGTTATTTC
AGTGCAGAATCGATTCACGTGTAAGCCTCTACCTCCTGCACTTACCCCAATGTAGACCCCCTTCCACAGTCCCCCTACAGAAGATCTCCCAAAACATTTC
CAACACAGAACTTCCATTCAATTCCCCTCCGACTGCCCGCCTCCCTCCTCCAGGACAGAGCACGCCCCAGGTTTCGAGACTGAACTACCCCCATCTACGG
AGTCCACCCCTCCCTCTCTAGAACCCCCTCAGTGTAGACGCCTCCTCTTTTCCTCTTTCCTCCCTACTTTTTCTAGTTTTTCTGCAGCCGACCTCCAGCG
TCGGCCACTGTAGCTCCTTCCTTGCTCCACTTTCCCCAGAGTACACAGCCTGCCTTTCCACTCTCCGTGCAGACCCATCCTCTTTCCCGCTCCTCGCTCT
CGGACGCCACCAACGCTCTCCCGGGCTCTTCCGCGTTACCTACGATGGAAGGTCGGGGCGTGCGGGCAGCTGGAACCCACCCCTGTCTTGGAGCTCCGGG
TAGCTCTCAAACTCGAGGCTGCGCACCCCCTTTCCCGTCAGCTGAGCTCTAGAGCGCTGGGGCTTTCTTTTTGATCGACTTCTTGAAATAAAACCAACTT
TATCATTCTTTGGGTAACAGACCCAAAAGCCGATGGGACGGCCCGCTGGGCTGTTCCCGCCCCTATGCCCTTTTTTGGGTTTCCGGCCAGAGGCATGCTG
GGAGCGTCACATGCAAATTGAGCGTGCACCCAGCGTTCCGCCCTTTCTACGCTGGGCCGGTTATCGACCCGGCCCAGTGCGCAGGCGCGGGAAAGTTGAA
CTAATAAAGTTTGTACGAGTTCAGTGGAGGAGACCGCAAGTTGAGTGGAGGAGGCGGCGGTGGGGCCCCGGACCAGGTGCCTCCATGGCAGGCTCTGAAG
AGCTGGGGCTCCGGGAAGACACGCTGAGGGTCCTAGCTGCCTTCCTTAGGCGTGGTGAGGCTGCCGGGTCTCCTGTTCCAACTCCACCTAGGCCCAGCTA
CTCCAGACTTCTATGCTTTGGTGGCCCAGCGGCTGGAACAGCTGGTCCAAGAGCAGCTGAAATCTCCGCCCAGCCCAGAATTACAGGGTCCCCCATCGAC
AGAGAAGGAAGCCATACTGCGGAGGCTGGTGGCCCTGCTGGAGGAGGAGGCAGAAGTCATTAACCAGAAGCTGGCCTCGGACCCCGCCCTGCGCAGCAAG
CTGGTCCGCCTGTCCTCCGACTCTTTCGCCCGCCTGGTGGAGCTGTTCTGTAGCCGGGATGACAGCTCTCGCCCAAGCCGAGCATGCCCCGGGCCCCCGC
CTCCTTCCCCGGAGCCCCTGGCCCGCCTGGCCCTAGCCATGGAGCTGAGCCGGCGCGTGGCCGGGCTGGGGGGCACCCTGGCCGGACTCAGCGTGGAGCA
CGTGCACAGCTTCACGCCCTGGATCCAGGCCCACGGGGGCTGGGAGGGCATCCTGGCTGTTTCACCCGTGGACTTGAACTTGCCATTGGACTGAGCTCTT
TCTCAGAAGCTGCTACAAGATGACACCTCATGTCCCTGCCCTCTTCGTGTGCTTTTCCAAGTCTTCCTATTCCACTCAGGGCTGTGGGGTGGTGGTTGCC
CTACCTGTTTTTGCCAAAAATAAATTGTTTAAAACTTTTCTTATTAAAAACGTTACAAAGTATTCAA
  • BCL2L12-3 (forward primer)
  • BCL2L12-4 (reverse primer)
  • Single exon skipping

Frame 0

LLLCILP*AVLPRDAEARAALVHPGHALQLPQV
QLRHQPGQDPWLWGSHGPACAYRAFPGRDRPPPD
PPGLEFPHPDLLLTGHGTGPSPIFSGVQTGNLL
FPSSHPPERLSNQLGFLPISMAHPSPASSVQTL
HSLNSASIDLLPPPHHRK*VSPLSG*HPLSLVIS
VQNRFTCKPLPPALTPM*TPFHSPPTEDLPKHF
QHRTSIQFPSDCPPPSSRTEHAPGFETELPPST
ESTPPSLEPPQCRRLLFSSFLPTFSSFSAADLQR
RPL*LLPCSTFPRVHSLPFHSPCRPILFPAPRS
RTPPTLSRALPRYLRWKVGACGQLEPTPVLELR
VALKLEAAHPLSRQLSSRALGLSF*STS*NKTNF
IILWVTDPKADGTARWAVPAPMPFFGFPARGML
GASHAN*ACTQRSALSTLGRLSTRPSAQARES*
TNKVCTSSVEETAS*VEEAAVGPRTRCLHGRL*R
AGAPGRHAEGPSCLP*AW*GCRVSCSNST*AQL
LQTSMLWWPSGWNSWSKSS*NLRPAQNYRVPHR
QRRKPYCGGWWPCWRRRQKSLTRSWPRTPPCAAS
WSACPPTLSPAWWSCSVAGMTALAQAEHAPGPR
LLPRSPWPAWP*PWS*AGAWPGWGAPWPDSAWS
TCTASRPGSRPTGAGRASWLFHPWT*TCHWTELF
LRSCYKMTPHVPALFVCFSKSSYSTQGCGVVVA
LPVFAKNKLFKTFLIKNVTKYS

Frame 1

SCCASCRRPCFQGMRKRVRLLFTQATPSSCPRS
SCDTSQGRIRGFGVPMVRPARIGHFLGATGLPR
THLAWSFRTQTSFSRATAQVLHPYFRGYKQETSS
SHPPILPRGSLIS*GSFPYPWHILPQRLQCRPS
TPSIPPV*TSSLPHIIESKYPHFQGSILFP*LF
QCRIDSRVSLYLLHLPQCRPPSTVPLQKISQNIS
NTELPFNSPPTARLPPPGQSTPQVSRLNYPHLR
SPPLPL*NPLSVDASSFPLSSLLFLVFLQPTSS
VGHCSSFLAPLSPEYTACLSTLRADPSSFPLLAL
GRHQRSPGLFRVTYDGRSGRAGSWNPPLSWSSG
*LSNSRLRTPFPVS*ALERWGFLFDRLLEIKPT
LSFFG*QTQKPMGRPAGLFPPLCPFLGFRPEACW
ERHMQIERAPSVPPFLRWAGYRPGPVRRRGKVE
LIKFVRVQWRRPQVEWRRRRWGPGPGASMAGSE
ELGLREDTLRVLAAFLRRGEAAGSPVPTPPRPSY
SRLLCFGGPAAGTAGPRAAEISAQPRITGSPID
REGSHTAEAGGPAGGGGRSH*PEAGLGPRPAQQ
AGPPVLRLFRPPGGAVL*PG*QLSPKPSMPRAPA
SFPGAPGPPGPSHGAEPARGRAGGHPGRTQRGA
RAQLHALDPGPRGLGGHPGCFTRGLELAIGLSS
FSEAATR*HLMSLPSSCAFPSLPIPLRAVGWWLP
YLFLPKINCLKLFLLKTLQSIQ

Frame 2

PAVHPAVGRASKGCGSACGSCSPRPRPPVAPGP
AATPARAGSVALGFPWSGLRV*GISWARPASPG
PTWPGVSAPRPPSHGPRHRSFTHIFGGTNRKPP
LPILPSSREAL*SARVPSHIHGTSFPSVFSADPP
LPQFRQYRPPPSPTSSKVSIPTFRVASSFPSYF
SAESIHV*ASTSCTYPNVDPLPQSPYRRSPKTF
PTQNFHSIPLRLPASLLQDRARPRFRD*TTPIYG
VHPSLSRTPSV*TPPLFLFPPYFF*FFCSRPPA
SATVAPSLLHFPQSTQPAFPLSVQTHPLSRSSL
SDATNALPGSSALPTMEGRGVRAAGTHPCLGAPG
SSQTRGCAPPFPSAEL*SAGAFFLIDFLK*NQL
YHSLGNRPKSRWDGPLGCSRPYALFWVSGQRHA
GSVTCKLSVHPAFRPFYAGPVIDPAQCAGAGKLN
**SLYEFSGGDRKLSGGGGGGAPDQVPPWQALK
SWGSGKTR*GS*LPSLGVVRLPGLLFQLHLGPA
TPDFYALVAQRLEQLVQEQLKSPPSPELQGPPST
EKEAILRRLVALLEEEAEVINQKLASDPALRSK
LVRLSSDSFARLVELFCSRDDSSRPSRACPGPP
PPSPEPLARLALAMELSRRVAGLGGTLAGLSVEH
VHSFTPWIQAHGGWEGILAVSPVDLNLPLD*AL
SQKLLQDDTSCPCPLRVLFQVFLFHSGLWGGGC
PTCFCQK*IV*NFSY*KRYKVF

Sequence BCL2L12.bAug05

CTCCTGCTGTGCATCCTGCCGTAGGCCGTGCTTCCAAGGGATGCGGAAGCGCGTGCGGCTCTTGTTCACCCAGGCCACGCCCTCCAGTTGCCCCAGGTCC
AGCTGCGACACCAGCCAGGGCAGGATCCGTGGCTTTGGGGTTCCCATGGTCCGGCCTGCGCGTATAGGGCATTTCCTGGGCGCGACCGGCCTCCCCCGGA
CCCACCTGGCCTGGAGTTTCCGCACCCAGACCTCCTTCTCACGGGCCACGGCACAGGTCCTTCACCCATATTTTCGGGGGTACAAACAGGAAACCTCCTC
TTCCCATCCTCCCATCCTCCCGAGAGGCTCTCTAATCAGCTAGGGTTCCTTCCCATATCCATGGCACATCCTTCCCCAGCGTCTTCAGTGCAGACCCTCC
ACTCCCTCAATTCCGCCAGTATAGACCTCCTCCCTCCCCCACATCATCGAAAGTAAGTATCCCCACTTTCAGGGTAGCATCCTCTTTCCCTAGTTATTTC
AGTGCAGAATCGATTCACGTGTAAGCCTCTACCTCCTGCACTTACCCCAATGTAGACCCCCTTCCACAGTCCCCCTACAGAAGATCTCCCAAAACATTTC
CAACACAGAACTTCCATTCAATTCCCCTCCGACTGCCCGCCTCCCTCCTCCAGGACAGAGCACGCCCCAGGTTTCGAGACTGAACTACCCCCATCTACGG
AGTCCACCCCTCCCTCTCTAGAACCCCCTCAGTGTAGACGCCTCCTCTTTTCCTCTTTCCTCCCTACTTTTTCTAGTTTTTCTGCAGCCGACCTCCAGCG
TCGGCCACTGTAGCTCCTTCCTTGCTCCACTTTCCCCAGAGTACACAGCCTGCCTTTCCACTCTCCGTGCAGACCCATCCTCTTTCCCGCTCCTCGCTCT
CGGACGCCACCAACGCTCTCCCGGGCTCTTCCGCGTTACCTACGATGGAAGGTCGGGGCGTGCGGGCAGCTGGAACCCACCCCTGTCTTGGAGCTCCGGG
TAGCTCTCAAACTCGAGGCTGCGCACCCCCTTTCCCGTCAGCTGAGCTCTAGAGCGCTGGGGCTTTCTTTTTGATCGACTTCTTGAAATAAAACCAACTT
TATCATTCTTTGGGTAACAGACCCAAAAGCCGATGGGACGGCCCGCTGGGCTGTTCCCGCCCCTATGCCCTTTTTTGGGTTTCCGGCCAGAGGCATGCTG
GGAGCGTCACATGCAAATTGAGCGTGCACCCAGCGTTCCGCCCTTTCTACGCTGGGCCGGTTATCGACCCGGCCCAGTGCGCAGGCGCGGGAAAGTTGAA
CTAATAAAGTTTGTACGAGTTCAGTGGAGGAGACCGCAAGTTGAGTGGAGGAGGCGGCGGTGGGGCCCCGGACCAGGTGCCTCCATGGCAGGCTCTGAAG
AGCTGGGGCTCCGGGAAGACACGCTGAGGGTCCTAGCTGCCTTCCTTAGGCGTGGTGAGGCTGCCGGGTCTCCTGTTCCAACTCCACCTAGCCCTGCCCA
AGAAGAGCCAACAGACTTCCTGAGCCGCCTTCGAAGATGTCTTCCCTGCTCCCTGGGGCGAGGAGCAGCCCCCTCTGAGTCCCCTCGGCCTTGCTCTCTG
CCCATCCGCCCCTGCTATGGTTTAGAGCCTGGCCCAGCTACTCCAGACTTCTATGCTTTGGTGGCCCAGCGGCTGGAACAGCTGGTCCAAGAGCAGCTGA
AATCTCCGCCCAGCCCAGAATTACAGGGTCCCCCATCGACAGAGAAGGAAGCCATACTGCGGAGGCTGGTGGCCCTGCTGGAGGAGGAGGCAGAAGTCAT
TAACCAGAAGCTGGCCTCGGACCCCGCCCTGCGCAGCAAGCTGGTCCGCCTGTCCTCCGACTCTTTCGCCCGCCTGGTGGAGCTGTTCTGTAGCCGGGAT
GACAGCTCTCGCCCAAGCCGAGCATGCCCCGGGCCCCCGCCTCCTTCCCCGGAGCCCCTGGCCCGCCTGGCCCTAGCCATGGAGCTGAGCCGGCGCGTGG
CCGGGCTGGGGGGCACCCTGGCCGGACTCAGCGTGGAGCACGTGCACAGCTTCACGCC
  • BCL2L12-3 (forward primer)
  • BCL2L12-4 (reverse primer)
  • Single exon skipping

Frame 0

LLLCILP*AVLPRDAEARAALVHPGHALQLPQV
QLRHQPGQDPWLWGSHGPACAYRAFPGRDRPPPD
PPGLEFPHPDLLLTGHGTGPSPIFSGVQTGNLL
FPSSHPPERLSNQLGFLPISMAHPSPASSVQTL
HSLNSASIDLLPPPHHRK*VSPLSG*HPLSLVIS
VQNRFTCKPLPPALTPM*TPFHSPPTEDLPKHF
QHRTSIQFPSDCPPPSSRTEHAPGFETELPPST
ESTPPSLEPPQCRRLLFSSFLPTFSSFSAADLQR
RPL*LLPCSTFPRVHSLPFHSPCRPILFPAPRS
RTPPTLSRALPRYLRWKVGACGQLEPTPVLELR
VALKLEAAHPLSRQLSSRALGLSF*STS*NKTNF
IILWVTDPKADGTARWAVPAPMPFFGFPARGML
GASHAN*ACTQRSALSTLGRLSTRPSAQARES*
TNKVCTSSVEETAS*VEEAAVGPRTRCLHGRL*R
AGAPGRHAEGPSCLP*AW*GCRVSCSNST*PCP
RRANRLPEPPSKMSSLLPGARSSPL*VPSALLS
AHPPLLWFRAWPSYSRLLCFGGPAAGTAGPRAAE
ISAQPRITGSPIDREGSHTAEAGGPAGGGGRSH
*PEAGLGPRPAQQAGPPVLRLFRPPGGAVL*PG
*QLSPKPSMPRAPASFPGAPGPPGPSHGAEPARG
RAGGHPGRTQRGARAQLHA

Frame 1

SCCASCRRPCFQGMRKRVRLLFTQATPSSCPRS
SCDTSQGRIRGFGVPMVRPARIGHFLGATGLPR
THLAWSFRTQTSFSRATAQVLHPYFRGYKQETSS
SHPPILPRGSLIS*GSFPYPWHILPQRLQCRPS
TPSIPPV*TSSLPHIIESKYPHFQGSILFP*LF
QCRIDSRVSLYLLHLPQCRPPSTVPLQKISQNIS
NTELPFNSPPTARLPPPGQSTPQVSRLNYPHLR
SPPLPL*NPLSVDASSFPLSSLLFLVFLQPTSS
VGHCSSFLAPLSPEYTACLSTLRADPSSFPLLAL
GRHQRSPGLFRVTYDGRSGRAGSWNPPLSWSSG
*LSNSRLRTPFPVS*ALERWGFLFDRLLEIKPT
LSFFG*QTQKPMGRPAGLFPPLCPFLGFRPEACW
ERHMQIERAPSVPPFLRWAGYRPGPVRRRGKVE
LIKFVRVQWRRPQVEWRRRRWGPGPGASMAGSE
ELGLREDTLRVLAAFLRRGEAAGSPVPTPPSPAQ
EEPTDFLSRLRRCLPCSLGRGAAPSESPRPCSL
PIRPCYGLEPGPATPDFYALVAQRLEQLVQEQL
KSPPSPELQGPPSTEKEAILRRLVALLEEEAEVI
NQKLASDPALRSKLVRLSSDSFARLVELFCSRD
DSSRPSRACPGPPPPSPEPLARLALAMELSRRV
AGLGGTLAGLSVEHVHSFT

Frame 2

PAVHPAVGRASKGCGSACGSCSPRPRPPVAPGP
AATPARAGSVALGFPWSGLRV*GISWARPASPG
PTWPGVSAPRPPSHGPRHRSFTHIFGGTNRKPP
LPILPSSREAL*SARVPSHIHGTSFPSVFSADPP
LPQFRQYRPPPSPTSSKVSIPTFRVASSFPSYF
SAESIHV*ASTSCTYPNVDPLPQSPYRRSPKTF
PTQNFHSIPLRLPASLLQDRARPRFRD*TTPIYG
VHPSLSRTPSV*TPPLFLFPPYFF*FFCSRPPA
SATVAPSLLHFPQSTQPAFPLSVQTHPLSRSSL
SDATNALPGSSALPTMEGRGVRAAGTHPCLGAPG
SSQTRGCAPPFPSAEL*SAGAFFLIDFLK*NQL
YHSLGNRPKSRWDGPLGCSRPYALFWVSGQRHA
GSVTCKLSVHPAFRPFYAGPVIDPAQCAGAGKLN
**SLYEFSGGDRKLSGGGGGGAPDQVPPWQALK
SWGSGKTR*GS*LPSLGVVRLPGLLFQLHLALP
KKSQQTS*AAFEDVFPAPWGEEQPPLSPLGLALC
PSAPAMV*SLAQLLQTSMLWWPSGWNSWSKSS*
NLRPAQNYRVPHRQRRKPYCGGWWPCWRRRQKS
LTRSWPRTPPCAASWSACPPTLSPAWWSCSVAGM
TALAQAEHAPGPRLLPRSPWPAWP*PWS*AGAW
PGWGAPWPDSAWSTCTASR

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