×
1 warning:
  • Access restricted to public data.
    Please sign in at Rnomics Platform to access your data.
Navigation
Sequences

Sequence NRG2.dAug05

CCTCCAGGTCCTGGCGCACAGGGTGGGAGCGCTGCGCTGCGCCGCGCTGCGCATCGCGGCCCGCTTGCCGCCTGCCCCCTGCCCTAGCTGGGCCACCTCC
CCGGGCTGCCGGTGGAGGGCTAAGAGGCGCTAACGTTACGCTGTTTCCGGTTTTCCAGCGGGCTCTGTTTCCCCTCCCAAGGCGGCGGCGGCTGAGCGGC
GGAGCCCCCCAAATGGCCTGGCCAGATGCGGCAGGTTTGCTGCTCAGCGCTGCCGCCGCCGCCACTGGAGAAGGGTCGGTGCAGCAGCTACAGCGACAGC
AGCAGCAGCAGCAGCGAGAGGAGCAGCAGCAGCAGCAGCAGCAGCAGCGAGAGCGGCAGCAGCAGCAGGAGCAGCAGCAACAACAGCAGCATCTCTCGTC
CCGCTGCGCCCCCAGAGCCGCGGCCGCAGCAACAGCCGCAGCCCCGCAGCCCCGCAGCCCGGAGAGCCGCCGCCCGTTCGCGAGCCGCAGCCGCCGGCGG
CATGAGGCGCGACCCGGCCCCCGGCTTCTCCATGCTGCTCTTCGGTGTGTCGCTCGCCTGCTACTCGCCCAGCCTCAAGTCAGTGCAGGACCAGGCGTAC
AAGGCACCCGTGGTGGTGGAGGGCAAGGTACAGGGGCTGGTCCCAGCCGGCGGCTCCAGCTCCAACAGCACCCGAGAGCCGCCCGCCTCGGGTCGGGTGG
CGTTGGTAAAGGTGCTGGACAAGTGGCCGCTCCGGAGCGGGGGGCTGCAGCGCGAGCAGGTGATCAGCGTGGGCTCCTGTGTGCCGCTCGAAAGGAACCA
GCGCTACATCTTTTTCCTGGAGCCCACGGAACAGCCCTTAGTCTTTAAGACGGCCTTTGCCCCCCTCGATACCAACGGCAAAAATCTCAAGAAAGAGGTG
GGCAAGATCCTGTGCACTGACTGCGCCACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGG
CAGCAGCCGGTAATCCCCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAA
GAACTCACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGGCCGG
CTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAGTGCAACGAGACAGCCAAGTCCTATTGCGTCAATGGAGGCGTCT
GCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAGTGTCCTGTGGGATACACCGGGGACAGGTGTCAGCAGTTCGCAATGGTCAACTTCTCCAAAGC
CGAGGAGCTGTACCAGAAGAGGGTCCTGACCATCACGGGCATCTGCGTGGCTCTGCTGGTCGTGGGCATCGTCTGTGTGGTGGCCTACTGCAAGACCAAA
AAACAGCGGAAGCAGATGCACAACCACCTCCGGCAGAACATGTGCCCGGCCCATCAGAACCGGAGCTTGGCCAATGGGCCCAGCCACCCCCGGCTGGACC
CAGAGGAGATCCAGATGGCAGATTATATTTCCAAGAACGTGCCAGCCACAGACCATGTCATCAGGAGAGAAACTGAGACCACCTTCTCTGGGAGCCACTC
CTGTTCTCCTTCTCACCACTGCTCCACAGCCACACCCACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTGGAACGTTCTGAGAGCCTGACTTCT
GACTCCCAGTCGGGGATCATGCTATCATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCGGGCAAGGCGGGCAGCAGCCTACAACC
TGGAGGAGCGGCGCAGGGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTCCCCACACAGCGAGAGGTACGTGTCGGCCCTGACCAC
GCCCGCGCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCCAACTTTCGAGATCACGTCCCCCAACTCGGCGCACGCCGTGTCGCTG
CCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCCGTTACTGCGGCACCCGGCGCCCCCCGGCCCGGGACCCGGACCCGGGCCCGGGCCCG
GGCCCGGCGCAGACATGCAGCGCAGCTATGACAGCTACTATTACCCCGCGGCGGGGCCCGGACCGCGGCGCGGGACCTGCGCGCTCGGCGGCAGCCTGGG
CAGCCTGCCTGCCAGCCCCTTCCGCATCCCCGAGGACGACGAGTACGAGACCACGCAGGAGTGCGCGCCCCCGCCGCCGCCGCGGCCGCGCGCGCGCGGT
GCGTCCCGCAGGACGTCGGCGGGGCCCCGGCGCTGGCGCCGCTCGCGCCTCAACGGGCTGGCGGCGCAGCGCGCACGGGCGGCGAGGGACTCGCTGTCGC
TGAGCAGCGGCTCGGGCGGCGGCTCAGCCTCGGCGTCGGACGACGACGCGGACGACGCGGACGGGGCGCTGGCGGCCGAGAGCACACCTTTCCTGGGCCT
GCGTGGGGCGCACGACGCGCTGCGCTCGGACTCGCCGCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCACTGGACAGCCACAGCACGCGGGCC
AGCAGCAGACACAGCCGCGGGCCGCCCCCGCGGGCCAAGCAGGACTCGGCGCCACTCTAGGGCCCCGCCGCGCGCCCCTCCGCCCCGCCCGCCCCACTAT
CTTTAAGGAGACCAGAGACCGCCTACTGGAGAGAAAGGAGGAAAAAAGAAATAAAAATATTTTTATTTTCTATAAAAGGAAAAAAGTATAACAAAATGTT
TTATTTTCATTTTAGCAAAAATTGTCTTATAATACTAGCTAACGGCAAAGGCGTTTTTATAGGGAAACTATTTATATGTAACATCCTGATTTACAGCTTC
GG
  • NRG2-7 (forward primer)
  • NRG2-8 (reverse primer)
  • Single exon skipping

Frame 0

PPGPGAQGGSAALRRAAHRGPLAACPLP*LGHL
PGLPVEG*EALTLRCFRFSSGLCFPSQGGGG*AA
EPPKWPGQMRQVCCSALPPPPLEKGRCSSYSDS
SSSSSERSSSSSSSSSESGSSSRSSSNNSSISR
PAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGG
MRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAY
KAPVVVEGKVQGLVPAGGSSSNSTREPPASGRV
ALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQ
RYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEV
GKILCTDCATRPKLKKMKSQTGQVGEKQSLKCE
AAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRK
NSRLQFNKVKVEDAGEYVCEAENILGKDTVRGR
LYVNSVSTTLSSWSGHARKCNETAKSYCVNGGV
CYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKA
EELYQKRVLTITGICVALLVVGIVCVVAYCKTK
KQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLD
PEEIQMADYISKNVPATDHVIRRETETTFSGSHS
CSPSHHCSTATPTSSHRHESHTWSLERSESLTS
DSQSGIMLSSVGTSKCNSPACVEARARRAAAYN
LEERRRATAPPYHDSVDSLRDSPHSERYVSALTT
PARLSPVDFHYSLATQVPTFEITSPNSAHAVSL
PPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGP
GPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLG
SLPASPFRIPEDDEYETTQECAPPPPPRPRARG
ASRRTSAGPRRWRRSRLNGLAAQRARAARDSLS
LSSGSGGGSASASDDDADDADGALAAESTPFLGL
RGAHDALRSDSPPLCPAADSRTYYSLDSHSTRA
SSRHSRGPPPRAKQDSAPL*GPAARPSAPPAPL
SLRRPETAYWRERRKKEIKIFLFSIKGKKYNKMF
YFHFSKNCLIILANGKGVFIGKLFICNILIYSF

Frame 1

LQVLAHRVGALRCAALRIAARLPPAPCPSWATS
PGCRWRAKRR*RYAVSGFPAGSVSPPKAAAAER
RSPPNGLARCGRFAAQRCRRRHWRRVGAAATATA
AAAAARGAAAAAAAAARAAAAAGAAATTAASLV
PLRPQSRGRSNSRSPAAPQPGEPPPVREPQPPA
A*GATRPPASPCCSSVCRSPATRPASSQCRTRRT
RHPWWWRARYRGWSQPAAPAPTAPESRPPRVGW
RW*RCWTSGRSGAGGCSASR*SAWAPVCRSKGT
SATSFSWSPRNSP*SLRRPLPPSIPTAKISRKRW
ARSCALTAPPGPS*RR*RARRDRWVRSNR*SVR
QQPVIPSLPTVGSRMARSSTAAETFASNMATAE
RTHDYSSTR*RWRTLGSMSARPRTSWGRTPSGAG
FTSTA*APPCHPGRGTPGSATRQPSPIASMEAS
ATTSRASTSSPASVLWDTPGTGVSSSQWSTSPK
PRSCTRRGS*PSRASAWLCWSWASSVWWPTARPK
NSGSRCTTTSGRTCARPIRTGAWPMGPATPGWT
QRRSRWQIIFPRTCQPQTMSSGEKLRPPSLGAT
PVLLLTTAPQPHPPPATDTRATRGAWNVLRA*LL
TPSRGSCYHQWVPANATAQHVWRPGQGGQQPTT
WRSGAGPPRHPITIPWTPFATPHTARGTCRP*P
RPRASRPWTSTTRWPRRCQLSRSRPPTRRTPCRC
RRRRPSVTAWPSSSRYCGTRRPPARDPDPGPGP
GPAQTCSAAMTATITPRRGPDRGAGPARSAAAW
AACLPAPSASPRTTSTRPRRSARPRRRRGRARAV
RPAGRRRGPGAGAARASTGWRRSAHGRRGTRCR
*AAARAAAQPRRRTTTRTTRTGRWRPRAHLSWA
CVGRTTRCARTRRHCARRPTAGLTTHWTATARGP
AADTAAGRPRGPSRTRRHSRAPPRAPPPRPPHY
L*GDQRPPTGEKGGKKK*KYFYFL*KEKSITKC
FIFILAKIVL*Y*LTAKAFL*GNYLYVTS*FTAS

Frame 2

SRSWRTGWERCAAPRCASRPACRLPPALAGPPP
RAAGGGLRGANVTLFPVFQRALFPLPRRRRLSG
GAPQMAWPDAAGLLLSAAAAATGEGSVQQLQRQ
QQQQQREEQQQQQQQQRERQQQQEQQQQQQHLSS
RCAPRAAAAATAAAPQPRSPESRRPFASRSRRR
HEARPGPRLLHAALRCVARLLLAQPQVSAGPGV
QGTRGGGGQGTGAGPSRRLQLQQHPRAARLGSGG
VGKGAGQVAAPERGAAARAGDQRGLLCAARKEP
ALHLFPGAHGTALSL*DGLCPPRYQRQKSQERG
GQDPVH*LRHPAQVEEDEEPDGTGG*EAIAEV*G
SSR*SPAFLPLVQGWQGAQPQPRHSHQIWQRQK
ELTTTVQQGEGGGRWGVCLRGREHPGEGHRPGP
ALRQQREHHPVILVGARPEVQRDSQVLLRQWRRL
LLHRGHQPALLQVSCGIHRGQVSAVRNGQLLQS
RGAVPEEGPDHHGHLRGSAGRGHRLCGGLLQDQ
KTAEADAQPPPAEHVPGPSEPELGQWAQPPPAGP
RGDPDGRLYFQERASHRPCHQERN*DHLLWEPL
LFSFSPLLHSHTHLQPQTREPHVEPGTF*EPDF
*LPVGDHAIISGYQQMQQPSMCGGPGKAGSSLQP
GGAAQGHRATLSRFRGLPSRLPTQREVRVGPDH
ARAPLARGLPLLAGHAGANFRDHVPQLGARRVA
AAGGAHQLPPGRAAAVTAAPGAPRPGTRTRARAR
ARRRHAAQL*QLLLPRGGARTAARDLRARRQPG
QPACQPLPHPRGRRVRDHAGVRAPAAAAAARAR
CVPQDVGGAPALAPLAPQRAGGAARTGGEGLAVA
EQRLGRRLSLGVGRRRGRRGRGAGGREHTFPGP
AWGARRAALGLAATVPGGRQQDLLLTGQPQHAG
QQQTQPRAAPAGQAGLGATLGPRRAPLRPARPTI
FKETRDRLLERKEEKRNKNIFIFYKRKKV*QNV
LFSF*QKLSYNTS*RQRRFYRETIYM*HPDLQL
R

Sequence NRG2.bAug05

CCTCCAGGTCCTGGCGCACAGGGTGGGAGCGCTGCGCTGCGCCGCGCTGCGCATCGCGGCCCGCTTGCCGCCTGCCCCCTGCCCTAGCTGGGCCACCTCC
CCGGGCTGCCGGTGGAGGGCTAAGAGGCGCTAACGTTACGCTGTTTCCGGTTTTCCAGCGGGCTCTGTTTCCCCTCCCAAGGCGGCGGCGGCTGAGCGGC
GGAGCCCCCCAAATGGCCTGGCCAGATGCGGCAGGTTTGCTGCTCAGCGCTGCCGCCGCCGCCACTGGAGAAGGGTCGGTGCAGCAGCTACAGCGACAGC
AGCAGCAGCAGCAGCGAGAGGAGCAGCAGCAGCAGCAGCAGCAGCAGCGAGAGCGGCAGCAGCAGCAGGAGCAGCAGCAACAACAGCAGCATCTCTCGTC
CCGCTGCGCCCCCAGAGCCGCGGCCGCAGCAACAGCCGCAGCCCCGCAGCCCCGCAGCCCGGAGAGCCGCCGCCCGTTCGCGAGCCGCAGCCGCCGGCGG
CATGAGGCGCGACCCGGCCCCCGGCTTCTCCATGCTGCTCTTCGGTGTGTCGCTCGCCTGCTACTCGCCCAGCCTCAAGTCAGTGCAGGACCAGGCGTAC
AAGGCACCCGTGGTGGTGGAGGGCAAGGTACAGGGGCTGGTCCCAGCCGGCGGCTCCAGCTCCAACAGCACCCGAGAGCCGCCCGCCTCGGGTCGGGTGG
CGTTGGTAAAGGTGCTGGACAAGTGGCCGCTCCGGAGCGGGGGGCTGCAGCGCGAGCAGGTGATCAGCGTGGGCTCCTGTGTGCCGCTCGAAAGGAACCA
GCGCTACATCTTTTTCCTGGAGCCCACGGAACAGCCCTTAGTCTTTAAGACGGCCTTTGCCCCCCTCGATACCAACGGCAAAAATCTCAAGAAAGAGGTG
GGCAAGATCCTGTGCACTGACTGCGCCACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGG
CAGCAGCCGGTAATCCCCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAA
GAACTCACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGGCCGG
CTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAGTGCAACGAGACAGCCAAGTCCTATTGCGTCAATGGAGGCGTCT
GCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAGTGTCCTGTGGGATACACCGGGGACAGGTGTCAGCAGTTCGCAATGGTCAACTTCTCCAAGCA
CCTTGGATTTGAATTAAAGGAAGCCGAGGAGCTGTACCAGAAGAGGGTCCTGACCATCACGGGCATCTGCGTGGCTCTGCTGGTCGTGGGCATCGTCTGT
GTGGTGGCCTACTGCAAGACCAAAAAACAGCGGAAGCAGATGCACAACCACCTCCGGCAGAACATGTGCCCGGCCCATCAGAACCGGAGCTTGGCCAATG
GGCCCAGCCACCCCCGGCTGGACCCAGAGGAGATCCAGATGGCAGATTATATTTCCAAGAACGTGCCAGCCACAGACCATGTCATCAGGAGAGAAACTGA
GACCACCTTCTCTGGGAGCCACTCCTGTTCTCCTTCTCACCACTGCTCCACAGCCACACCCACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTG
GAACGTTCTGAGAGCCTGACTTCTGACTCCCAGTCGGGGATCATGCTATCATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCGGG
CAAGGCGGGCAGCAGCCTACAACCTGGAGGAGCGGCGCAGGGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTCCCCACACAGCGA
GAGGTACGTGTCGGCCCTGACCACGCCCGCGCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCCAACTTTCGAGATCACGTCCCCC
AACTCGGCGCACGCCGTGTCGCTGCCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCCGTTACTGCGGCACCCGGCGCCCCCCGGCCCGG
GACCCGGACCCGGGCCCGGGCCCGGGCCCGGCGCAGACATGCAGCGCAGCTATGACAGCTACTATTACCCCGCGGCGGGGCCCGGACCGCGGCGCGGGAC
CTGCGCGCTCGGCGGCAGCCTGGGCAGCCTGCCTGCCAGCCCCTTCCGCATCCCCGAGGACGACGAGTACGAGACCACGCAGGAGTGCGCGCCCCCGCCG
CCGCCGCGGCCGCGCGCGCGCGGTGCGTCCCGCAGGACGTCGGCGGGGCCCCGGCGCTGGCGCCGCTCGCGCCTCAACGGGCTGGCGGCGCAGCGCGCAC
GGGCGGCGAGGGACTCGCTGTCGCTGAGCAGCGGCTCGGGCGGCGGCTCAGCCTCGGCGTCGGACGACGACGCGGACGACGCGGACGGGGCGCTGGCGGC
CGAGAGCACACCTTTCCTGGGCCTGCGTGGGGCGCACGACGCGCTGCGCTCGGACTCGCCGCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCA
CTGGACAGCCACAGCACGCGGGCCAGCAGCAGACACAGCCGCGGGCCGCCCCCGCGGGCCAAGCAGGACTCGGCGCCACTCTAGGGCCCCGCCGCGCGCC
CCTCCGCCCCGCCCGCCCCACTATCTTTAAGGAGACCAGAGACCGCCTACTGGAGAGAAAGGAGGAAAAAAGAAATAAAAATATTTTTATTTTCTATAAA
AGGAAAAAAGTATAACAAAATGTTTTATTTTCATTTTAGCAAAAATTGTCTTATAATACTAGCTAACGGCAAAGGCGTTTTTATAGGGAAACTATTTATA
TGTAACATCCTGATTTACAGCTTCGG
  • NRG2-7 (forward primer)
  • NRG2-8 (reverse primer)
  • Single exon skipping

Frame 0

PPGPGAQGGSAALRRAAHRGPLAACPLP*LGHL
PGLPVEG*EALTLRCFRFSSGLCFPSQGGGG*AA
EPPKWPGQMRQVCCSALPPPPLEKGRCSSYSDS
SSSSSERSSSSSSSSSESGSSSRSSSNNSSISR
PAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGG
MRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAY
KAPVVVEGKVQGLVPAGGSSSNSTREPPASGRV
ALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQ
RYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEV
GKILCTDCATRPKLKKMKSQTGQVGEKQSLKCE
AAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRK
NSRLQFNKVKVEDAGEYVCEAENILGKDTVRGR
LYVNSVSTTLSSWSGHARKCNETAKSYCVNGGV
CYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKH
LGFELKEAEELYQKRVLTITGICVALLVVGIVC
VVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLAN
GPSHPRLDPEEIQMADYISKNVPATDHVIRRETE
TTFSGSHSCSPSHHCSTATPTSSHRHESHTWSL
ERSESLTSDSQSGIMLSSVGTSKCNSPACVEAR
ARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSE
RYVSALTTPARLSPVDFHYSLATQVPTFEITSP
NSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGP
GPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGT
CALGGSLGSLPASPFRIPEDDEYETTQECAPPP
PPRPRARGASRRTSAGPRRWRRSRLNGLAAQRA
RAARDSLSLSSGSGGGSASASDDDADDADGALAA
ESTPFLGLRGAHDALRSDSPPLCPAADSRTYYS
LDSHSTRASSRHSRGPPPRAKQDSAPL*GPAAR
PSAPPAPLSLRRPETAYWRERRKKEIKIFLFSIK
GKKYNKMFYFHFSKNCLIILANGKGVFIGKLFI
CNILIYSF

Frame 1

LQVLAHRVGALRCAALRIAARLPPAPCPSWATS
PGCRWRAKRR*RYAVSGFPAGSVSPPKAAAAER
RSPPNGLARCGRFAAQRCRRRHWRRVGAAATATA
AAAAARGAAAAAAAAARAAAAAGAAATTAASLV
PLRPQSRGRSNSRSPAAPQPGEPPPVREPQPPA
A*GATRPPASPCCSSVCRSPATRPASSQCRTRRT
RHPWWWRARYRGWSQPAAPAPTAPESRPPRVGW
RW*RCWTSGRSGAGGCSASR*SAWAPVCRSKGT
SATSFSWSPRNSP*SLRRPLPPSIPTAKISRKRW
ARSCALTAPPGPS*RR*RARRDRWVRSNR*SVR
QQPVIPSLPTVGSRMARSSTAAETFASNMATAE
RTHDYSSTR*RWRTLGSMSARPRTSWGRTPSGAG
FTSTA*APPCHPGRGTPGSATRQPSPIASMEAS
ATTSRASTSSPASVLWDTPGTGVSSSQWSTSPS
TLDLN*RKPRSCTRRGS*PSRASAWLCWSWASSV
WWPTARPKNSGSRCTTTSGRTCARPIRTGAWPM
GPATPGWTQRRSRWQIIFPRTCQPQTMSSGEKL
RPPSLGATPVLLLTTAPQPHPPPATDTRATRGAW
NVLRA*LLTPSRGSCYHQWVPANATAQHVWRPG
QGGQQPTTWRSGAGPPRHPITIPWTPFATPHTA
RGTCRP*PRPRASRPWTSTTRWPRRCQLSRSRPP
TRRTPCRCRRRRPSVTAWPSSSRYCGTRRPPAR
DPDPGPGPGPAQTCSAAMTATITPRRGPDRGAG
PARSAAAWAACLPAPSASPRTTSTRPRRSARPRR
RRGRARAVRPAGRRRGPGAGAARASTGWRRSAH
GRRGTRCR*AAARAAAQPRRRTTTRTTRTGRWR
PRAHLSWACVGRTTRCARTRRHCARRPTAGLTTH
WTATARGPAADTAAGRPRGPSRTRRHSRAPPRA
PPPRPPHYL*GDQRPPTGEKGGKKK*KYFYFL*
KEKSITKCFIFILAKIVL*Y*LTAKAFL*GNYLY
VTS*FTAS

Frame 2

SRSWRTGWERCAAPRCASRPACRLPPALAGPPP
RAAGGGLRGANVTLFPVFQRALFPLPRRRRLSG
GAPQMAWPDAAGLLLSAAAAATGEGSVQQLQRQ
QQQQQREEQQQQQQQQRERQQQQEQQQQQQHLSS
RCAPRAAAAATAAAPQPRSPESRRPFASRSRRR
HEARPGPRLLHAALRCVARLLLAQPQVSAGPGV
QGTRGGGGQGTGAGPSRRLQLQQHPRAARLGSGG
VGKGAGQVAAPERGAAARAGDQRGLLCAARKEP
ALHLFPGAHGTALSL*DGLCPPRYQRQKSQERG
GQDPVH*LRHPAQVEEDEEPDGTGG*EAIAEV*G
SSR*SPAFLPLVQGWQGAQPQPRHSHQIWQRQK
ELTTTVQQGEGGGRWGVCLRGREHPGEGHRPGP
ALRQQREHHPVILVGARPEVQRDSQVLLRQWRRL
LLHRGHQPALLQVSCGIHRGQVSAVRNGQLLQA
PWI*IKGSRGAVPEEGPDHHGHLRGSAGRGHRL
CGGLLQDQKTAEADAQPPPAEHVPGPSEPELGQW
AQPPPAGPRGDPDGRLYFQERASHRPCHQERN*
DHLLWEPLLFSFSPLLHSHTHLQPQTREPHVEP
GTF*EPDF*LPVGDHAIISGYQQMQQPSMCGGPG
KAGSSLQPGGAAQGHRATLSRFRGLPSRLPTQR
EVRVGPDHARAPLARGLPLLAGHAGANFRDHVP
QLGARRVAAAGGAHQLPPGRAAAVTAAPGAPRPG
TRTRARARARRRHAAQL*QLLLPRGGARTAARD
LRARRQPGQPACQPLPHPRGRRVRDHAGVRAPA
AAAAARARCVPQDVGGAPALAPLAPQRAGGAART
GGEGLAVAEQRLGRRLSLGVGRRRGRRGRGAGG
REHTFPGPAWGARRAALGLAATVPGGRQQDLLL
TGQPQHAGQQQTQPRAAPAGQAGLGATLGPRRAP
LRPARPTIFKETRDRLLERKEEKRNKNIFIFYK
RKKV*QNVLFSF*QKLSYNTS*RQRRFYRETIY
M*HPDLQLR

Sequence NRG2.fAug05

CCTCCAGGTCCTGGCGCACAGGGTGGGAGCGCTGCGCTGCGCCGCGCTGCGCATCGCGGCCCGCTTGCCGCCTGCCCCCTGCCCTAGCTGGGCCACCTCC
CCGGGCTGCCGGTGGAGGGCTAAGAGGCGCTAACGTTACGCTGTTTCCGGTTTTCCAGCGGGCTCTGTTTCCCCTCCCAAGGCGGCGGCGGCTGAGCGGC
GGAGCCCCCCAAATGGCCTGGCCAGATGCGGCAGGTTTGCTGCTCAGCGCTGCCGCCGCCGCCACTGGAGAAGGGTCGGTGCAGCAGCTACAGCGACAGC
AGCAGCAGCAGCAGCGAGAGGAGCAGCAGCAGCAGCAGCAGCAGCAGCGAGAGCGGCAGCAGCAGCAGGAGCAGCAGCAACAACAGCAGCATCTCTCGTC
CCGCTGCGCCCCCAGAGCCGCGGCCGCAGCAACAGCCGCAGCCCCGCAGCCCCGCAGCCCGGAGAGCCGCCGCCCGTTCGCGAGCCGCAGCCGCCGGCGG
CATGAGGCGCGACCCGGCCCCCGGCTTCTCCATGCTGCTCTTCGGTGTGTCGCTCGCCTGCTACTCGCCCAGCCTCAAGTCAGTGCAGGACCAGGCGTAC
AAGGCACCCGTGGTGGTGGAGGGCAAGGTACAGGGGCTGGTCCCAGCCGGCGGCTCCAGCTCCAACAGCACCCGAGAGCCGCCCGCCTCGGGTCGGGTGG
CGTTGGTAAAGGTGCTGGACAAGTGGCCGCTCCGGAGCGGGGGGCTGCAGCGCGAGCAGGTGATCAGCGTGGGCTCCTGTGTGCCGCTCGAAAGGAACCA
GCGCTACATCTTTTTCCTGGAGCCCACGGAACAGCCCTTAGTCTTTAAGACGGCCTTTGCCCCCCTCGATACCAACGGCAAAAATCTCAAGAAAGAGGTG
GGCAAGATCCTGTGCACTGACTGCGCCACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGG
CAGCAGCCGGTAATCCCCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAA
GAACTCACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGGCCGG
CTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAGTGCAACGAGACAGCCAAGTCCTATTGCGTCAATGGAGGCGTCT
GCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAATGTCCAAATGGATTCTTCGGACAGAGATGTTTGGAGAAACTGCCTTTGCGATTGTACATGCC
AGATCCTAAGCAAA
GTGTCCTGTGGGATACACCGGGGACAGGTGTCAGCAGTTCGCAATGGTCAACTTCTCCAAGCACCTTGGATTTGAATTAAAGG
  • NRG2-7 (forward primer)
  • NRG2-8 (reverse primer)
  • Single exon skipping

Frame 0

PPGPGAQGGSAALRRAAHRGPLAACPLP*LGHL
PGLPVEG*EALTLRCFRFSSGLCFPSQGGGG*AA
EPPKWPGQMRQVCCSALPPPPLEKGRCSSYSDS
SSSSSERSSSSSSSSSESGSSSRSSSNNSSISR
PAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGG
MRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAY
KAPVVVEGKVQGLVPAGGSSSNSTREPPASGRV
ALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQ
RYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEV
GKILCTDCATRPKLKKMKSQTGQVGEKQSLKCE
AAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRK
NSRLQFNKVKVEDAGEYVCEAENILGKDTVRGR
LYVNSVSTTLSSWSGHARKCNETAKSYCVNGGV
CYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMP
DPKQ
SVLWDTPGTGVSSSQWSTSPSTLDLN*R

Frame 1

LQVLAHRVGALRCAALRIAARLPPAPCPSWATS
PGCRWRAKRR*RYAVSGFPAGSVSPPKAAAAER
RSPPNGLARCGRFAAQRCRRRHWRRVGAAATATA
AAAAARGAAAAAAAAARAAAAAGAAATTAASLV
PLRPQSRGRSNSRSPAAPQPGEPPPVREPQPPA
A*GATRPPASPCCSSVCRSPATRPASSQCRTRRT
RHPWWWRARYRGWSQPAAPAPTAPESRPPRVGW
RW*RCWTSGRSGAGGCSASR*SAWAPVCRSKGT
SATSFSWSPRNSP*SLRRPLPPSIPTAKISRKRW
ARSCALTAPPGPS*RR*RARRDRWVRSNR*SVR
QQPVIPSLPTVGSRMARSSTAAETFASNMATAE
RTHDYSSTR*RWRTLGSMSARPRTSWGRTPSGAG
FTSTA*APPCHPGRGTPGSATRQPSPIASMEAS
ATTSRASTSSPANVQMDSSDRDVWRNCLCDCTC
QILSK
VSCGIHRGQVSAVRNGQLLQAPWI*IK

Frame 2

SRSWRTGWERCAAPRCASRPACRLPPALAGPPP
RAAGGGLRGANVTLFPVFQRALFPLPRRRRLSG
GAPQMAWPDAAGLLLSAAAAATGEGSVQQLQRQ
QQQQQREEQQQQQQQQRERQQQQEQQQQQQHLSS
RCAPRAAAAATAAAPQPRSPESRRPFASRSRRR
HEARPGPRLLHAALRCVARLLLAQPQVSAGPGV
QGTRGGGGQGTGAGPSRRLQLQQHPRAARLGSGG
VGKGAGQVAAPERGAAARAGDQRGLLCAARKEP
ALHLFPGAHGTALSL*DGLCPPRYQRQKSQERG
GQDPVH*LRHPAQVEEDEEPDGTGG*EAIAEV*G
SSR*SPAFLPLVQGWQGAQPQPRHSHQIWQRQK
ELTTTVQQGEGGGRWGVCLRGREHPGEGHRPGP
ALRQQREHHPVILVGARPEVQRDSQVLLRQWRRL
LLHRGHQPALLQMSKWILRTEMFGETAFAIVHA
RS*AK
CPVGYTGDRCQQFAMVNFSKHLGFELK

Sequence NRG2.eAug05

CCTCCAGGTCCTGGCGCACAGGGTGGGAGCGCTGCGCTGCGCCGCGCTGCGCATCGCGGCCCGCTTGCCGCCTGCCCCCTGCCCTAGCTGGGCCACCTCC
CCGGGCTGCCGGTGGAGGGCTAAGAGGCGCTAACGTTACGCTGTTTCCGGTTTTCCAGCGGGCTCTGTTTCCCCTCCCAAGGCGGCGGCGGCTGAGCGGC
GGAGCCCCCCAAATGGCCTGGCCAGATGCGGCAGGTTTGCTGCTCAGCGCTGCCGCCGCCGCCACTGGAGAAGGGTCGGTGCAGCAGCTACAGCGACAGC
AGCAGCAGCAGCAGCGAGAGGAGCAGCAGCAGCAGCAGCAGCAGCAGCGAGAGCGGCAGCAGCAGCAGGAGCAGCAGCAACAACAGCAGCATCTCTCGTC
CCGCTGCGCCCCCAGAGCCGCGGCCGCAGCAACAGCCGCAGCCCCGCAGCCCCGCAGCCCGGAGAGCCGCCGCCCGTTCGCGAGCCGCAGCCGCCGGCGG
CATGAGGCGCGACCCGGCCCCCGGCTTCTCCATGCTGCTCTTCGGTGTGTCGCTCGCCTGCTACTCGCCCAGCCTCAAGTCAGTGCAGGACCAGGCGTAC
AAGGCACCCGTGGTGGTGGAGGGCAAGGTACAGGGGCTGGTCCCAGCCGGCGGCTCCAGCTCCAACAGCACCCGAGAGCCGCCCGCCTCGGGTCGGGTGG
CGTTGGTAAAGGTGCTGGACAAGTGGCCGCTCCGGAGCGGGGGGCTGCAGCGCGAGCAGGTGATCAGCGTGGGCTCCTGTGTGCCGCTCGAAAGGAACCA
GCGCTACATCTTTTTCCTGGAGCCCACGGAACAGCCCTTAGTCTTTAAGACGGCCTTTGCCCCCCTCGATACCAACGGCAAAAATCTCAAGAAAGAGGTG
GGCAAGATCCTGTGCACTGACTGCGCCACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGG
CAGCAGCCGGTAATCCCCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAA
GAACTCACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGGCCGG
CTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAGTGCAACGAGACAGCCAAGTCCTATTGCGTCAATGGAGGCGTCT
GCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAATGTCCAAATGGATTCTTCGGACAGAGATGTTTGGAGAAACTGCCTTTGCGATTGTACATGCC
AGATCCTAAGCAAA
GTGTCCTGTGGGATACACCGGGGACAGGTGTCAGCAGTTCGCAATGGTCAACTTCTCCAAAGCCGAGGAGCTGTACCAGAAGAGGG
TCCTGACCATCACGGGCATCTGCGTGGCTCTGCTGGTCGTGGGCATCGTCTGTGTGGTGGCCTACTGCAAGACCAA
  • NRG2-7 (forward primer)
  • NRG2-8 (reverse primer)
  • Single exon skipping

Frame 0

PPGPGAQGGSAALRRAAHRGPLAACPLP*LGHL
PGLPVEG*EALTLRCFRFSSGLCFPSQGGGG*AA
EPPKWPGQMRQVCCSALPPPPLEKGRCSSYSDS
SSSSSERSSSSSSSSSESGSSSRSSSNNSSISR
PAAPPEPRPQQQPQPRSPAARRAAARSRAAAAGG
MRRDPAPGFSMLLFGVSLACYSPSLKSVQDQAY
KAPVVVEGKVQGLVPAGGSSSNSTREPPASGRV
ALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQ
RYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEV
GKILCTDCATRPKLKKMKSQTGQVGEKQSLKCE
AAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRK
NSRLQFNKVKVEDAGEYVCEAENILGKDTVRGR
LYVNSVSTTLSSWSGHARKCNETAKSYCVNGGV
CYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMP
DPKQ
SVLWDTPGTGVSSSQWSTSPKPRSCTRRG
S*PSRASAWLCWSWASSVWWPTARP

Frame 1

LQVLAHRVGALRCAALRIAARLPPAPCPSWATS
PGCRWRAKRR*RYAVSGFPAGSVSPPKAAAAER
RSPPNGLARCGRFAAQRCRRRHWRRVGAAATATA
AAAAARGAAAAAAAAARAAAAAGAAATTAASLV
PLRPQSRGRSNSRSPAAPQPGEPPPVREPQPPA
A*GATRPPASPCCSSVCRSPATRPASSQCRTRRT
RHPWWWRARYRGWSQPAAPAPTAPESRPPRVGW
RW*RCWTSGRSGAGGCSASR*SAWAPVCRSKGT
SATSFSWSPRNSP*SLRRPLPPSIPTAKISRKRW
ARSCALTAPPGPS*RR*RARRDRWVRSNR*SVR
QQPVIPSLPTVGSRMARSSTAAETFASNMATAE
RTHDYSSTR*RWRTLGSMSARPRTSWGRTPSGAG
FTSTA*APPCHPGRGTPGSATRQPSPIASMEAS
ATTSRASTSSPANVQMDSSDRDVWRNCLCDCTC
QILSK
VSCGIHRGQVSAVRNGQLLQSRGAVPEEG
PDHHGHLRGSAGRGHRLCGGLLQDQ

Frame 2

SRSWRTGWERCAAPRCASRPACRLPPALAGPPP
RAAGGGLRGANVTLFPVFQRALFPLPRRRRLSG
GAPQMAWPDAAGLLLSAAAAATGEGSVQQLQRQ
QQQQQREEQQQQQQQQRERQQQQEQQQQQQHLSS
RCAPRAAAAATAAAPQPRSPESRRPFASRSRRR
HEARPGPRLLHAALRCVARLLLAQPQVSAGPGV
QGTRGGGGQGTGAGPSRRLQLQQHPRAARLGSGG
VGKGAGQVAAPERGAAARAGDQRGLLCAARKEP
ALHLFPGAHGTALSL*DGLCPPRYQRQKSQERG
GQDPVH*LRHPAQVEEDEEPDGTGG*EAIAEV*G
SSR*SPAFLPLVQGWQGAQPQPRHSHQIWQRQK
ELTTTVQQGEGGGRWGVCLRGREHPGEGHRPGP
ALRQQREHHPVILVGARPEVQRDSQVLLRQWRRL
LLHRGHQPALLQMSKWILRTEMFGETAFAIVHA
RS*AK
CPVGYTGDRCQQFAMVNFSKAEELYQKR
VLTITGICVALLVVGIVCVVAYCKT

Copyright ©2008,2017, all rights reserved.