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Sequence SPP1.kAug05
CTCCCTGTGTTGGTGGAGGATGTCTGCAGCAGCATTTAAATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGG
CATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCACTAAAGATGTACCTACCCCTCCACAACAGATGAAACTGTG
CCAGCCAAACAACAAATGGGCATTGTCCCCAGAAGCTTGGACAAAAAGGCACACAGAGTTCAATTCCAGTTGAACAGAATAAAGGCCAAAATAGAGCTGC
CTTGGGGGTCACTGCAATTAGACTGCTTAATGAAGACATTAAAAGAAGTATTCTGTCTTTACAACAAATACCCAGATGCTGTGGCCACATGGCTAAACCC
TGACCCATCTCAGAAGCAGAATCTCCTAGCCCCACAGACCCTTCCAAGTAAGTCCAACGAAAGCCATGACCACATGGATGATATGGATGATGAAGATGAT
GATGACCATGTGGACAGCCAGGACTCCATTGACTCGAACGACTCTGATGATGTAGATGACACTGATGATTCTCACCAGTCTGATGAGTCTCACCATTCTG
ATGAATCTGATGAACTGGTCACTGATTTTCCCACGGACCTGCCAGCAACCGAAGTTTTCACTCCAGTTGTCCCCACAGTAGACACATATGATGGCCGAGG
TGATAGTGTGGTTTATGGACTGAGGTCAAAATCTAAGAAGTTTCGCAGACCTGACATCCAGGTAAATCCTTTAACAGACACACCTGATGGTTCTGACTAG
CGCTCAAGTCTAGGAAACCACAGTTTGCATATTCATTCATTCATTCATCCATTCATTCATCCATTCAGCAAGAATTCATTCATATTCTACTTTATGACCA
TTGAATACAAATCTTTTTCTGCTTGGCGGTTTTTGTAAGTCTACATAATTTCTCTCTAGATTTGATTCTCAAACACAATTCTACTTTTTGAAATCCTGGA
TCACTTATTTTCAGATTAAAATAAATGGAAAACACCAATTATTT
- SPP1-3 (forward primer)
- SPP1-4 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
LPVLVEDVCSSI*ILGGLGCQQQQEEAEHSIVGTRLVSGQLQPSQPNADQGKLTTMRIAVICFCLLG
ITCAIPVKQADSGSSEEKQH*RCTYPSTTDETV
PAKQQMGIVPRSLDKKAHRVQFQLNRIKAKIEL
PWGSLQLDCLMKTLKEVFCLYNKYPDAVATWLNP
DPSQKQNLLAPQTLPSKSNESHDHMDDMDDEDD
DDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHS
DESDELVTDFPTDLPATEVFTPVVPTVDTYDGRG
DSVVYGLRSKSKKFRRPDIQVNPLTDTPDGSD*
RSSLGNHSLHIHSFIHPFIHPFSKNSFIFYFMT
IEYKSFSAWRFL*VYIISL*I*FSNTILLFEILD
HLFSD*NKWKTPII
Frame 1
SLCWWRMSAAAFKFWEGLVVSSSRRRQSTASSGPDSSQASCSLLSQTPTKENSLP*ELQ*FAFAS*
ASPVPYQLNRLILEVLRKSSTKDVPTPPQQMKLC
QPNNKWALSPEAWTKRHTEFNSS*TE*RPK*SC
LGGHCN*TA**RH*KKYSVFTTNTQMLWPHG*T
LTHLRSRIS*PHRPFQVSPTKAMTTWMIWMMKMM
MTMWTARTPLTRTTLMM*MTLMILTSLMSLTIL
MNLMNWSLIFPRTCQQPKFSLQLSPQ*THMMAE
VIVWFMD*GQNLRSFADLTSR*IL*QTHLMVLTS
AQV*ETTVCIFIHSFIHSFIHSARIHSYSTL*P
LNTNLFLLGGFCKST*FLSRFDSQTQFYFLKSW
ITYFQIKINGKHQLF
Frame 2
PCVGGGCLQQHLNSGRAWLSAAAGGGRAQHRRDQTRLRPVAAFSAKRRPRKTHYHENCSDLLLPPR
HHLCHTS*TG*FWKF*GKAALKMYLPLHNR*NC
ASQTTNGHCPQKLGQKGTQSSIPVEQNKGQNRAA
LGVTAIRLLNEDIKRSILSLQQIPRCCGHMAKP
*PISEAESPSPTDPSK*VQRKP*PHG*YG**R*
**PCGQPGLH*LERL**CR*H**FSPV**VSPF*
*I**TGH*FSHGPASNRSFHSSCPHSRHI*WPR
**CGLWTEVKI*EVSQT*HPGKSFNRHT*WF*L
ALKSRKPQFAYSFIHSSIHSSIQQEFIHILLYDH
*IQIFFCLAVFVSLHNFSLDLILKHNSTF*NPG
SLIFRLK*MENTNY
Sequence SPP1.hAug05
CTCCCTGTGTTGGTGGAGGATGTCTGCAGCAGCATTTAAATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGG
CATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTTCTGAGGACCCATCTCAGAAGCAGAATCTCCTAGCCCCACAGACCCTTCCAAGTAAG
TCCAACGAAAGCCATGACCACATGGATGATATGGATGATGAAGATGATGATGACCATGTGGACAGCCAGGACTCCATTGACTCGAACGACTCTGATGATG
TAGATGACACTGATGATTCTCACCAGTCTGATGAGTCTCACCATTCTGATGAATCTGATGAACTGGTCACTGATTTTCCCACGGACCTGCCAGCAACCGA
AGTTTTCACTCCAGTTGTCCCCACAGTAGACACATATGATGGCCGAGGTGATAGTGTGGTTTATGGACTGAGGTCAAAATCTAAGAAGTTTCGCAGACCT
GACATCCAGTACCCTGATGCTACAGACGAGGACATCACCTCACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACC
TGAACGCGCCTTCTGATTGGGACAGCCGTGGGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAG
ATTATATAAGCGGAAAGCCAATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAA
TTTCACAGCCATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTGCATCTT
CTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACATGAAATGCTT
CTTTCTCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTGT
AAACTAAAAGCTTCAGGGTTATGTCTATGTTCATTCTATAGAAGAAATGCAAACTATCACTGTATTTTAATATTTGTTATTCTCTCATGAATAGAAATTT
ATGTAGAAGCAAACAAAATACTTTTACCCACTTAAAAAGAGAATATAACATTTTATGTCACTATAATCTTTTGTTTTTTAAGTTAGTGTATATTTTGTTG
TGATTATCTTTTTGTGGTGTGAATAAATCTTTTATCTTGAATGTAATAAGAATTTGGTGGTGTCAATTGCTTATTTGTTTTCCCACGGTTGTCCAGCAAT
TAATAAAACATAACCTTTTTTACTGCCTATATAA
- SPP1-3 (forward primer)
- SPP1-4 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
LPVLVEDVCSSI*ILGGLGCQQQQEEAEHSIVGTRLVSGQLQPSQPNADQGKLTTMRIAVICFCLLG
ITCAIPVKQADSGSSEDPSQKQNLLAPQTLPSK
SNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDD
VDDTDDSHQSDESHHSDESDELVTDFPTDLPATE
VFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRP
DIQYPDATDEDITSHMESEELNGAYKAIPVAQD
LNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSR
LYKRKANDESNEHSDVIDSQELSKVSREFHSHE
FHSHEDMLVVDPKSKEEDKHLKFRISHELDSAS
SEVN*KEKKYNFSLCI*SKEKMLYSKMKENMKCF
FLSLLVECVSI*VWK*LMCLIISLVCGFMETPC
KLKASGLCLCSFYRRNANYHCILIFVILS*IEI
YVEANKILLPT*KENITFYVTIIFCFLS*CIFCC
DYLFVV*INLLS*M**EFGGVNCLFVFPRLSSN
**NITFFTAYI
Frame 1
SLCWWRMSAAAFKFWEGLVVSSSRRRQSTASSGPDSSQASCSLLSQTPTKENSLP*ELQ*FAFAS*
ASPVPYQLNRLILEVLRTHLRSRIS*PHRPFQVS
PTKAMTTWMIWMMKMMMTMWTARTPLTRTTLMM
*MTLMILTSLMSLTILMNLMNWSLIFPRTCQQP
KFSLQLSPQ*THMMAEVIVWFMD*GQNLRSFADL
TSSTLMLQTRTSPHTWKARS*MVHTRPSPLPRT
*TRLLIGTAVGRTVMKRVSWMTRVLKPTATSSP
DYISGKPMMRAMSIPM*LIVRNFPKSAVNSTAMN
FTAMKICWL*TPKVRKKINT*NFVFLMN*IVHL
LRSIKRRKNTISHFAFSQKKKCFIAK*KRT*NA
SFSVYWLNVYLFESGNN*CV**LV*FVASWKLPV
N*KLQGYVYVHSIEEMQTITVF*YLLFSHE*KF
M*KQTKYFYPLKKRI*HFMSL*SFVF*VSVYFV
VIIFLWCE*IFYLECNKNLVVSIAYLFSHGCPAI
NKT*PFLLPI*
Frame 2
PCVGGGCLQQHLNSGRAWLSAAAGGGRAQHRRDQTRLRPVAAFSAKRRPRKTHYHENCSDLLLPPR
HHLCHTS*TG*FWKF*GPISEAESPSPTDPSK*
VQRKP*PHG*YG**R***PCGQPGLH*LERL**C
R*H**FSPV**VSPF**I**TGH*FSHGPASNR
SFHSSCPHSRHI*WPR**CGLWTEVKI*EVSQT
*HPVP*CYRRGHHLTHGKRGVEWCIQGHPRCPGP
ERAF*LGQPWEGQL*NESAG*PEC*NPQPQAVQ
II*AESQ**EQ*AFRCD**SGTFQSQP*IPQP*
ISQP*RYAGCRPQK*GRR*TPEISYFS*IR*CIF
*GQLKGEKIQFLTLHLVKRKNAL*QNEREHEML
LSQFIG*MCIYLSLEITNVFDN*FSLWLHGNSL
*TKSFRVMSMFIL*KKCKLSLYFNICYSLMNRNL
CRSKQNTFTHLKREYNILCHYNLLFFKLVYILL
*LSFCGVNKSFILNVIRIWWCQLLICFPTVVQQ
LIKHNLFYCLY
Sequence SPP1.eAug05
CTCCCTGTGTTGGTGGAGGATGTCTGCAGCAGCATTTAAATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGG
CATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGCTAAAC
CCTGACCCATCTCAGAAGCAGAATCTCCTAGCCCCACAGACCCTTCCAAGTAAGTCCAACGAAAGCCATGACCACATGGATGATATGGATGATGAAGATG
ATGATGACCATGTGGACAGCCAGGACTCCATTGACTCGAACGACTCTGATGATGTAGATGACACTGATGATTCTCACCAGTCTGATGAGTCTCACCATTC
TGATGAATCTGATGAACTGGTCACTGATTTTCCCACGGACCTGCCAGCAACCGAAGTTTTCACTCCAGTTGTCCCCACAGTAGACACATATGATGGCCGA
GGTGATAGTGTGGTTTATGGACTGAGGTCGGACATCACCTCACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACC
TGAACGCGCCTTCTGATTGGGACAGCCGTGGGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAG
ATTATATAAGCGGAAAGCCAATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAA
TTTCACAGCCATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTGCATCTT
CTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACATGAAATGCTT
CTTTCTCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTGT
AAACTAAAAGCTTCAGGGTTATGTCTATGTTCATTCTATAGAAGAAATGCAAACTATCACTGTATTTTAATATTTGTTATTCTCTCATGAATAGAAATTT
ATGTAGAAGCAAACAAAATACTTTTACCCACTTAAAAAGAGAATATAACATTTTATGTCACTATAATCTTTTGTTTTTTAAGTTAGTGTATATTTTGTTG
TGATTATCTTTTTGTGGTGTGAATAAATCTTTTATCTTGAATGTAATAAGAATTTGGTGGTGTCAATTGCTTATTTGTTTTCCCACGGTTGTCCAGCAAT
TAATAAAACATAACCTTTTTTACTGCCTATATAA
- SPP1-3 (forward primer)
- SPP1-4 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
LPVLVEDVCSSI*ILGGLGCQQQQEEAEHSIVGTRLVSGQLQPSQPNADQGKLTTMRIAVICFCLLG
ITCAIPVKQADSGSSEEKQLYNKYPDAVATWLN
PDPSQKQNLLAPQTLPSKSNESHDHMDDMDDED
DDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHS
DESDELVTDFPTDLPATEVFTPVVPTVDTYDGR
GDSVVYGLRSDITSHMESEELNGAYKAIPVAQD
LNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSR
LYKRKANDESNEHSDVIDSQELSKVSREFHSHE
FHSHEDMLVVDPKSKEEDKHLKFRISHELDSAS
SEVN*KEKKYNFSLCI*SKEKMLYSKMKENMKCF
FLSLLVECVSI*VWK*LMCLIISLVCGFMETPC
KLKASGLCLCSFYRRNANYHCILIFVILS*IEI
YVEANKILLPT*KENITFYVTIIFCFLS*CIFCC
DYLFVV*INLLS*M**EFGGVNCLFVFPRLSSN
**NITFFTAYI
Frame 1
SLCWWRMSAAAFKFWEGLVVSSSRRRQSTASSGPDSSQASCSLLSQTPTKENSLP*ELQ*FAFAS*
ASPVPYQLNRLILEVLRKSSFTTNTQMLWPHG*T
LTHLRSRIS*PHRPFQVSPTKAMTTWMIWMMKM
MMTMWTARTPLTRTTLMM*MTLMILTSLMSLTI
LMNLMNWSLIFPRTCQQPKFSLQLSPQ*THMMAE
VIVWFMD*GRTSPHTWKARS*MVHTRPSPLPRT
*TRLLIGTAVGRTVMKRVSWMTRVLKPTATSSP
DYISGKPMMRAMSIPM*LIVRNFPKSAVNSTAMN
FTAMKICWL*TPKVRKKINT*NFVFLMN*IVHL
LRSIKRRKNTISHFAFSQKKKCFIAK*KRT*NA
SFSVYWLNVYLFESGNN*CV**LV*FVASWKLPV
N*KLQGYVYVHSIEEMQTITVF*YLLFSHE*KF
M*KQTKYFYPLKKRI*HFMSL*SFVF*VSVYFV
VIIFLWCE*IFYLECNKNLVVSIAYLFSHGCPAI
NKT*PFLLPI*
Frame 2
PCVGGGCLQQHLNSGRAWLSAAAGGGRAQHRRDQTRLRPVAAFSAKRRPRKTHYHENCSDLLLPPR
HHLCHTS*TG*FWKF*GKAALQQIPRCCGHMAK
P*PISEAESPSPTDPSK*VQRKP*PHG*YG**R*
**PCGQPGLH*LERL**CR*H**FSPV**VSPF
**I**TGH*FSHGPASNRSFHSSCPHSRHI*WP
R**CGLWTEVGHHLTHGKRGVEWCIQGHPRCPGP
ERAF*LGQPWEGQL*NESAG*PEC*NPQPQAVQ
II*AESQ**EQ*AFRCD**SGTFQSQP*IPQP*
ISQP*RYAGCRPQK*GRR*TPEISYFS*IR*CIF
*GQLKGEKIQFLTLHLVKRKNAL*QNEREHEML
LSQFIG*MCIYLSLEITNVFDN*FSLWLHGNSL
*TKSFRVMSMFIL*KKCKLSLYFNICYSLMNRNL
CRSKQNTFTHLKREYNILCHYNLLFFKLVYILL
*LSFCGVNKSFILNVIRIWWCQLLICFPTVVQQ
LIKHNLFYCLY
Sequence SPP1.bAug05
CTCCCTGTGTTGGTGGAGGATGTCTGCAGCAGCATTTAAATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGG
CATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGCTAAAC
CCTGACCCATCTCAGAAGCAGAATCTCCTAGCCCCACAGACCCTTCCAAGTAAGTCCAACGAAAGCCATGACCACATGGATGATATGGATGATGAAGATG
ATGATGACCATGTGGACAGCCAGGACTCCATTGACTCGAACGACTCTGATGATGTAGATGACACTGATGATTCTCACCAGTCTGATGAGTCTCACCATTC
TGATGAATCTGATGAACTGGTCACTGATTTTCCCACGGACCTGCCAGCAACCGAAGTTTTCACTCCAGTTGTCCCCACAGTAGACACATATGATGGCCGA
GGTGATAGTGTGGTTTATGGACTGAGGTCAAAATCTAAGAAGTTTCGCAGACCTGACATCCAGTACCCTGATGCTACAGACGAGGACATCACCTCACACA
TGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGCCTTCTGATTGGGACAGCCGTGGGAAGGACAGTTATGA
AACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAGATTATATAAGCGGAAAGCCAATGATGAGAGCAATGAGCATTCCGAT
GTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAATTTCACAGCCATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGG
AAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTGCATCTTCTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGCAT
TTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACATGAAATGCTTCTTTCTCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAA
TAACTAATGTGTTTGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTGTAAACTAAAAGCTTCAGGGTTATGTCTATGTTCATTCTATAGAAGAA
ATGCAAACTATCACTGTATTTTAATATTTGTTATTCTCTCATGAATAGAAATTTATGTAGAAGCAAACAAAATACTTTTACCCACTTAAAAAGAGAATAT
AACATTTTATGTCACTATAATCTTTTGTTTTTTAAGTTAGTGTATATTTTGTTGTGATTATCTTTTTGTGGTGTGAATAAATCTTTTATCTTGAATGTAA
TAAGAATTTGGTGGTGTCAATTGCTTATTTGTTTTCCCACGGTTGTCCAGCAATTAATAAAACATAACCTTTTTTACTGCCTATATAA
- SPP1-3 (forward primer)
- SPP1-4 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
LPVLVEDVCSSI*ILGGLGCQQQQEEAEHSIVGTRLVSGQLQPSQPNADQGKLTTMRIAVICFCLLG
ITCAIPVKQADSGSSEEKQLYNKYPDAVATWLN
PDPSQKQNLLAPQTLPSKSNESHDHMDDMDDED
DDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHS
DESDELVTDFPTDLPATEVFTPVVPTVDTYDGR
GDSVVYGLRSKSKKFRRPDIQYPDATDEDITSH
MESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYE
TSQLDDQSAETHSHKQSRLYKRKANDESNEHSD
VIDSQELSKVSREFHSHEFHSHEDMLVVDPKSK
EEDKHLKFRISHELDSASSEVN*KEKKYNFSLCI
*SKEKMLYSKMKENMKCFFLSLLVECVSI*VWK
*LMCLIISLVCGFMETPCKLKASGLCLCSFYRR
NANYHCILIFVILS*IEIYVEANKILLPT*KENI
TFYVTIIFCFLS*CIFCCDYLFVV*INLLS*M*
*EFGGVNCLFVFPRLSSN**NITFFTAYI
Frame 1
SLCWWRMSAAAFKFWEGLVVSSSRRRQSTASSGPDSSQASCSLLSQTPTKENSLP*ELQ*FAFAS*
ASPVPYQLNRLILEVLRKSSFTTNTQMLWPHG*T
LTHLRSRIS*PHRPFQVSPTKAMTTWMIWMMKM
MMTMWTARTPLTRTTLMM*MTLMILTSLMSLTI
LMNLMNWSLIFPRTCQQPKFSLQLSPQ*THMMAE
VIVWFMD*GQNLRSFADLTSSTLMLQTRTSPHT
WKARS*MVHTRPSPLPRT*TRLLIGTAVGRTVM
KRVSWMTRVLKPTATSSPDYISGKPMMRAMSIPM
*LIVRNFPKSAVNSTAMNFTAMKICWL*TPKVR
KKINT*NFVFLMN*IVHLLRSIKRRKNTISHFA
FSQKKKCFIAK*KRT*NASFSVYWLNVYLFESGN
N*CV**LV*FVASWKLPVN*KLQGYVYVHSIEE
MQTITVF*YLLFSHE*KFM*KQTKYFYPLKKRI
*HFMSL*SFVF*VSVYFVVIIFLWCE*IFYLECN
KNLVVSIAYLFSHGCPAINKT*PFLLPI*
Frame 2
PCVGGGCLQQHLNSGRAWLSAAAGGGRAQHRRDQTRLRPVAAFSAKRRPRKTHYHENCSDLLLPPR
HHLCHTS*TG*FWKF*GKAALQQIPRCCGHMAK
P*PISEAESPSPTDPSK*VQRKP*PHG*YG**R*
**PCGQPGLH*LERL**CR*H**FSPV**VSPF
**I**TGH*FSHGPASNRSFHSSCPHSRHI*WP
R**CGLWTEVKI*EVSQT*HPVP*CYRRGHHLTH
GKRGVEWCIQGHPRCPGPERAF*LGQPWEGQL*
NESAG*PEC*NPQPQAVQII*AESQ**EQ*AFR
CD**SGTFQSQP*IPQP*ISQP*RYAGCRPQK*G
RR*TPEISYFS*IR*CIF*GQLKGEKIQFLTLH
LVKRKNAL*QNEREHEMLLSQFIG*MCIYLSLE
ITNVFDN*FSLWLHGNSL*TKSFRVMSMFIL*KK
CKLSLYFNICYSLMNRNLCRSKQNTFTHLKREY
NILCHYNLLFFKLVYILL*LSFCGVNKSFILNV
IRIWWCQLLICFPTVVQQLIKHNLFYCLY
Sequence SPP1.dAug05
CTCCCTGTGTTGGTGGAGGATGTCTGCAGCAGCATTTAAATTCTGGGAGGGCTTGGTTGTCAGCAGCAGCAGGAGGAGGCAGAGCACAGCATCGTCGGGACCAGACTCGTCTCAGGCCAGTTGCAGCCTTCTCAGCCAAACGCCGACCAAGGAAAACTCACTACCATGAGAATTGCAGTGATTTGCTTTTGCCTCCTAGG
CATCACCTGTGCCATACCAGTTAAACAGGCTGATTCTGGAAGTTCTGAGGAAAAGCAGCTTTACAACAAATACCCAGATGCTGTGGCCACATGGCTAAAC
CCTGACCCATCTCAGAAGCAGAATCTCCTAGCCCCACAGAATGCTGTGTCCTCTGAAGAAACCAATGACTTTAAACAAGAGTCCAACGAAAGCCATGACC
ACATGGATGATATGGATGATGAAGATGATGATGACCATGTGGACAGCCAGGACTCCATTGACTCGAACGACTCTGATGATGTAGATGACACTGATGATTC
TCACCAGTCTGATGAGTCTCACCATTCTGATGAATCTGATGAACTGGTCACTGATTTTCCCACGGACCTGCCAGCAACCGAAGTTTTCACTCCAGTTGTC
CCCACAGTAGACACATATGATGGCCGAGGTGATAGTGTGGTTTATGGACTGAGGTCAAAATCTAAGAAGTTTCGCAGACCTGACATCCAGTACCCTGATG
CTACAGACGAGGACATCACCTCACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGCCTTCTGATTG
GGACAGCCGTGGGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAGATTATATAAGCGGAAAGCC
AATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAATTTCACAGCCATGAAGATA
TGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTGCATCTTCTGAGGTCAATTAAAAGGA
GAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACATGAAATGCTTCTTTCTCAGTTTATTGGTT
GAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTGTAAACTAAAAGCTTCAGGGT
TATGTCTATGTTCATTCTATAGAAGAAATGCAAACTATCACTGTATTTTAATATTTGTTATTCTCTCATGAATAGAAATTTATGTAGAAGCAAACAAAAT
ACTTTTACCCACTTAAAAAGAGAATATAACATTTTATGTCACTATAATCTTTTGTTTTTTAAGTTAGTGTATATTTTGTTGTGATTATCTTTTTGTGGTG
TGAATAAATCTTTTATCTTGAATGTAATAAGAATTTGGTGGTGTCAATTGCTTATTTGTTTTCCCACGGTTGTCCAGCAATTAATAAAACATAACCTTTT
TTACTGCCTATATAA
- SPP1-3 (forward primer)
- SPP1-4 (reverse primer)
- Exon skipping and alternative donor or acceptor
Frame 0
LPVLVEDVCSSI*ILGGLGCQQQQEEAEHSIVGTRLVSGQLQPSQPNADQGKLTTMRIAVICFCLLG
ITCAIPVKQADSGSSEEKQLYNKYPDAVATWLN
PDPSQKQNLLAPQNAVSSEETNDFKQESNESHD
HMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDS
HQSDESHHSDESDELVTDFPTDLPATEVFTPVV
PTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPD
ATDEDITSHMESEELNGAYKAIPVAQDLNAPSDW
DSRGKDSYETSQLDDQSAETHSHKQSRLYKRKA
NDESNEHSDVIDSQELSKVSREFHSHEFHSHED
MLVVDPKSKEEDKHLKFRISHELDSASSEVN*KE
KKYNFSLCI*SKEKMLYSKMKENMKCFFLSLLV
ECVSI*VWK*LMCLIISLVCGFMETPCKLKASG
LCLCSFYRRNANYHCILIFVILS*IEIYVEANKI
LLPT*KENITFYVTIIFCFLS*CIFCCDYLFVV
*INLLS*M**EFGGVNCLFVFPRLSSN**NITF
FTAYI
Frame 1
SLCWWRMSAAAFKFWEGLVVSSSRRRQSTASSGPDSSQASCSLLSQTPTKENSLP*ELQ*FAFAS*
ASPVPYQLNRLILEVLRKSSFTTNTQMLWPHG*T
LTHLRSRIS*PHRMLCPLKKPMTLNKSPTKAMT
TWMIWMMKMMMTMWTARTPLTRTTLMM*MTLMI
LTSLMSLTILMNLMNWSLIFPRTCQQPKFSLQLS
PQ*THMMAEVIVWFMD*GQNLRSFADLTSSTLM
LQTRTSPHTWKARS*MVHTRPSPLPRT*TRLLI
GTAVGRTVMKRVSWMTRVLKPTATSSPDYISGKP
MMRAMSIPM*LIVRNFPKSAVNSTAMNFTAMKI
CWL*TPKVRKKINT*NFVFLMN*IVHLLRSIKR
RKNTISHFAFSQKKKCFIAK*KRT*NASFSVYWL
NVYLFESGNN*CV**LV*FVASWKLPVN*KLQG
YVYVHSIEEMQTITVF*YLLFSHE*KFM*KQTK
YFYPLKKRI*HFMSL*SFVF*VSVYFVVIIFLWC
E*IFYLECNKNLVVSIAYLFSHGCPAINKT*PF
LLPI*
Frame 2
PCVGGGCLQQHLNSGRAWLSAAAGGGRAQHRRDQTRLRPVAAFSAKRRPRKTHYHENCSDLLLPPR
HHLCHTS*TG*FWKF*GKAALQQIPRCCGHMAK
P*PISEAESPSPTECCVL*RNQ*L*TRVQRKP*P
HG*YG**R***PCGQPGLH*LERL**CR*H**F
SPV**VSPF**I**TGH*FSHGPASNRSFHSSC
PHSRHI*WPR**CGLWTEVKI*EVSQT*HPVP*C
YRRGHHLTHGKRGVEWCIQGHPRCPGPERAF*L
GQPWEGQL*NESAG*PEC*NPQPQAVQII*AES
Q**EQ*AFRCD**SGTFQSQP*IPQP*ISQP*RY
AGCRPQK*GRR*TPEISYFS*IR*CIF*GQLKG
EKIQFLTLHLVKRKNAL*QNEREHEMLLSQFIG
*MCIYLSLEITNVFDN*FSLWLHGNSL*TKSFRV
MSMFIL*KKCKLSLYFNICYSLMNRNLCRSKQN
TFTHLKREYNILCHYNLLFFKLVYILL*LSFCG
VNKSFILNVIRIWWCQLLICFPTVVQQLIKHNLF
YCLY
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