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Sequences

Sequence TRAF2.cAug05

CGGTAGCTGGGCGGGCCCTTAGTTCCGGGCGCGCTGCGACCGTTGGGGCTTTGTTCGCGGGGGTCACAGCTCTCATGGCTGCAGCTAGCGTGACCCCCCC TGGCTCCCTGGAGTTGCTACAGCCCGGCTTCTCCAAGACCCTCCTGGGGACCAAGCTGGAAGCCAAGTACCTGTGCTCCGCCTGCAGAAACGTCCTCCGC AGGCCCTTCCAGGCGCAGTGTGGCCACCGGTACTGCTCCTTCTGCCTGGCCAGCATCCTCAGCTCTGGGCCTCAGAACTGTGCTGCCTGTGTTCACGAGG GCATATATGAAGAAGGCATTTCTATTTTAGAAAGCAGTTCGGCCTTCCCAGATAATGCTGCCCGCAGGGAGGTGGAGAGCCTGCCGGCCGTCTGTCCCAG TGATGGATGCACCTGGAAGGGGACCCTGAAAGAATACGAGGTAAAGATGCCTGCGTGTGGCATGGTGACAGAAGCTCCAGCAGTCGGGAGTCGTCCACGC TCCCCAAGCAGTTATGACCTTGTCCTGCACGTTCCTCTCACTGGGGCTGAAGCCTGTCTGATGTCTGTGGAGGAAGAGACGGAGCTGCTCCTTAGAAGCT GCCACGAAGGCCGCTGCCCGCTCATGCTGACCGAATGTCCCGCGTGCAAAGGCCTGGTCCGCCTTGGTGAAAAGGAGCGCCACCTGGAGCACGAGTGCCC GGAGAGAAGCCTGAGCTGCCGGCATTGCCGGGCACCCTGCTGCGGAGCAGACGTGAAGGCGCACCACGAGGTCTGCCCCAAGTTCCCCTTAACTTGTGAC GGCTGCGGCAAGAAGAAGATCCCCCGGGAGAAGCTGGACCAAGACAAGATTGAAGCCCTGAGTAGCAAGGTGCAGCAGCTGGAGAGGAGCATTGGCCTCA AGGACCTGGCGATGGCTGACTTGGAGCAGAAGGTCTTGGAGATGGAGGCATCCACCTACGATGGGGTCTTCATCTGGAAGATCTCAGACTTCGCCAGGAA GCGCCAGGAAGCTGTGGCTGGCCGCATACCCGCCATCTTCTCCCCAGCCTTCTACACCAGCAGGTACGGCTACAAGATGTGTCTGCGTATCTACCTGAAC GGCGACGGCACCGGGCGAGGAACACACCTGTCCCTCTTCTTTGTGGTGATGAAGGGCCCGAATGACGCCCTGCTGCGGTGGCCCTTCAACCAGAAGGTGA CCTTAATGCTGCTCGACCAGAATAACCGGGAGCACGTGATTGACGCCTTCAGGCCCGACGTGACTTCATCCTCTTTTCAGAGGCCAGTCAACGACATGAA CATCGCAAGCGGCTGCCCCCTCTTCTGCCCCGTCTCCAAGATGGAGGCAAAGAATTCCTACGTGCGGGACGATGCCATCTTCATCAAGGCCATTGTGGAC CTGACAGGGCTCTAACTGCCCCCTACTGGTGTCTGGGGGTTGGGGGCAGCCAGGCACAGCCGGCTCACGGAGGGGCCACCACGCTGGGCCAGGGTCTCAC TGTACAAGTGGGCAGGGGCCGCGCTTGGGCGCTTGGGAGGGTGTCGGCCTGCAGCCAAGTTCACTGTCACGGGGGAAGGAGCCACCAGCCAGTCCTCAGA TTTCAGAGACTGCGGAGGGGCTTGGCAGACGGTCTTAGCCAAGGGCTGTGGTGGCATTGGCCGAGGGTCTTCGGGTGCTTCCCAGCACAAGCTGCCCTTG CTGTCCTGTGCAGTGAAGGGAGAGGCCCTGGGTGGGGGACACTCAGAGTGGGAGCACATCCCAGCAGTGCCCATGTAGCAGGAGCACAGTGGATGGCCTT GTGTCCCTCGGGCATGACAGGCAGAAACGAGGGCTGCTCCAGGAGAAGGGCCTCCTGCTGGCCAGAGCAAGGAAGGCTGAGCAGCTTGGTTCTCCCCTCT GGCCCCTGGAGAGAAGGGAGCATTCCTAGACCCCTGGGTGCTTGTCTGCACAGAGCTCTGGTCTGTGCCACCTTGGCCAGGCTGGCTGTGGGAGAGGGTC TGGTCCCACGCCGCCTCTGCTCAGACCACTGTGTGGGAGGTGCACAGCACAGCCTGCGGGTAAAGTGTGAGAGCTTGCCATCCAGCTCACGAAGACAGAG TTATTAAACCATTCAAATCTCTGTGGTCAGTGGCATCCATTTGATTCCAGGTTGCCTGCGGCTTCCAGCCTTGGCAGTGGTGACCCTCTGCGGGTCCTCC TGGCCTCTCCTCTCACAGACCCCTCCCCACGGGGTGCCTAGCCCCTGCCTGCTTCTCTAGCTAGCCAGGCTGTGTTCTCTGTTCCTCACCTGATGTAAGC TCCCTCTTCTCGAGCCTTGTTCCCTCTTCTGGAATGTTCTTCCCTGTCCATCTCCTCTCCTGGGCCTCCCCAGGGACTCCTGTGAGAGCAGAATGAGGAT GAGCCAGCCCTGGTCCTGCCTTTCTGTGCACAGGCTCCACCGAGCATCCTGGCTGCACCCGGGGGGTCCTGGCCACACCGAGGGTCCTGGCTGCACCGCC CCTGTGGTGTGTTTTTGGGACAGTGCAGGCAGGCGTAGGCACGGCTTCACACTCGGTGTCAGGGCAGCCGTGCTGGGACCTACTGGGCATCTGTATCGGG GTCCAGGATAAAGTGCTGTCCCCTCTCGACGTCTTCACGCACTGCTGTAGTTTGAGAAGTTGACCACAGAAAAGTACAGAAAATAACTCAGGCACGGAGC TGACCGACGGGCATTGTCTGTGTTCCGTGAGTGTGTACTGGGCCTAAAGAGCAAGCATTGCAGAGCCCTGCTGTTCCCTTTCCCGGCCTCACCTCAGCTC CCCAGGCCACGTGGCGGGAATTGAGGCGTTCCGGTTCTCTTTGGGCTTTAGAATTTTGCATCTGTACGTTTCTGTATTCACAAATAAGAATATTGCATTA AAAATGCAGAAACCATCCACTGGGTCAGCTGCAGGTAGCTGGGCTTTTGACTCAGCCTGGCTACTTTTAATGCATCTTGTGCTGGGCACTCTACATGGTG GATTCTGACTGCCGTGTGTGAGTTCCCTAGAGAGCACCTTCCAGTCTCTTCCCGTGTCTTCAGGGTTTGGTGACTGGAGATAGCCAGACCTGCTCTCGTG GGTCTCCTGTCAACCTGGAAGGAGGGTTGGTGGTTTCTAGGCCTCCCCTTTTTAGCAGTTGCCAGCTTGCTTTGCAGAGGGGCTGCATCCGGTCCTTCCA CCAGCACCAGGGGGAGGGTTCCCATCACTCCCATCCCTCCCATCCCTGCCCGTGCTTCGTGTTGTTGGAATTGAGATGCTGCAGCGTGCTGTGTGTGAAG TGAAGTGGCATCGCTGTCACGTGCGTTTCTCTGATGACTCGGCGGAGTCAGGCGTCTTTACCACGCTTACCTCTCCCTTGGATTCTCTCCCGTGCGAATT GCCTGTTGATGTCTTTTTCTCATTTTTCTTCTGGTTGTTGGTCTGGGTCTTATTCTGCTGGTTGGTAGGAGTTCCTGATATTCCTGATTACGGATTCTCG GTTGTGTCTTTGAACTGCGTTTCTGTTGCTCCTGATGTGCAGAAGCTTAAGCCTTACACATGATCAGCTGATCTTATCCTTTATGAATGGTGCTATTTCC GACCGACTCAGAACATCCTGACCTTCCCTGAGGCTGGAAACCACTGTCATGTTTTCGTCTAATGATTGTGAAGTTTTGTCTTTAACATACTGGGCTTCTA TATTTGGGGATTTGTTTGTATGTGACAGGTTTTGCTGGGTCACTGCAGTTTGTTAAAACAGATTGATTGAGGTCATCTCTTCTCACTTAAAACGAAATGG AACTGTGAAATGAGAGGAATGGACCAAAAAAAAATCCTCCCCCAGGGACAAAGATGGGGAAGAAGCCAACATCCCACAAAGGATTTGAACCCATTTTGGA AGGTGGGAAGTGGGTTGGTGGGTGGCTGCTGAGCAGAAGAGGGCTGAGGGGGAAGCTGGCCACACCGGGAGGCCCTGGCATGGAGCAGAGTCTAAAAGTG GATCAACTGAAAGACGGGGCAGAGCAGCTACCTTGGAGGTCCTTTGCCAGAGCAGCCGGATGGTCCTCCTGGCCCTCACCTCCCTGCAGTGGAGATGGAG GTCTGGAGAACCTGGGGAAGAGCTGAGGACCGCACCCCCCACGCAGTGAGAGCAGCATCGGGCTCCAGGCTGCAGAAGGGGCAGAGGTCTGCACTCGGAA CAATTCCCTAGGCACTGGCTGCCACACCAAGAGGCTCCCACGAAGCAGACCAAGGCCCTTGAGGGACAAAATGCTCTGGAGCAGCCCCGTGGGCAGGCCT GGCCCAGCCGCCTCATGGCCTTCTGGGGAAGTGACAGGCTCTGTGCAAACCCACAGAGGTACCATCGTCACTACCTAATTTTGGGACATTTCATCACCCT GCAGAGAAACCTTCCCTTAGCAGTCACTGTTCCCTCCCGCTCAGCCCCTGACAGCCAGCCATAAACCTACCTTCTGTCTCTATAGATTTGCCTACTCAGG ACATTCATGTGAATGTGGCCTTTGCTTTTACTCAGCAAGATATTTTCATGGTTCCTGTGTGTTGCAGCATGCATTGGAGTTTCATTCCTTCTAATGGCTG AATAATCTCTTGTATGGATGCACCACACCTTATTTATCCATTCATCCGTTGCTGGACATTTGGGTGGTTTCTACTTTTTGGCTACTCTGAAAATGCTGCT GTGAACATTTGTGAACAAGTTTTTATGGGGACGTG

TRAF2-3 (forward primer)
TRAF2-4 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

R*LGGPLVPGALRPLGLCSRGSQLSWLQLA*PP LAPWSCYSPASPRPSWGPSWKPSTCAPPAETSSA GPSRRSVATGTAPSAWPASSALGLRTVLPVFTR AYMKKAFLF*KAVRPSQIMLPAGRWRACRPSVP VMDAPGRGP*KNTR*RCLRVAW*QKLQQSGVVHA PQAVMTLSCTFLSLGLKPV*CLWRKRRSCSLEA ATKAAARSC*PNVPRAKAWSALVKRSATWSTSA RREA*AAGIAGHPAAEQT*RRTTRSAPSSP*LVT AAARRRSPGRSWTKTRLKP*VARCSSWRGALAS RTWRWLTWSRRSWRWRHPPTMGSSSGRSQTSPG SARKLWLAAYPPSSPQPSTPAGTATRCVCVST*T ATAPGEEHTCPSSLW**RARMTPCCGGPSTRR* P*CCSTRITGST*LTPSGPT*LHPLFRGQSTT* TSQAAAPSSAPSPRWRQRIPTCGTMPSSSRPLWT *QGSNCPLLVSGGWGQPGTAGSRRGHHAGPGSH CTSGQGPRLGAWEGVGLQPSSLSRGKEPPASPQ ISETAEGLGRRS*PRAVVALAEGLRVLPSTSCPC CPVQ*RERPWVGDTQSGSTSQQCPCSRSTVDGL VSLGHDRQKRGLLQEKGLLLARARKAEQLGSPL WPLERREHS*TPGCLSAQSSGLCHLGQAGCGRGS GPTPPLLRPLCGRCTAQPAGKV*ELAIQLTKTE LLNHSNLCGQWHPFDSRLPAASSLGSGDPLRVL LASPLTDPSPRGA*PLPASLASQAVFSVPHLM*A PSSRALFPLLECSSLSISSPGPPQGLL*EQNED EPALVLPFCAQAPPSILAAPGGSWPHRGSWLHR PCGVFLGQCRQA*ARLHTRCQGSRAGTYWASVSG SRIKCCPLSTSSRTAVV*EVDHRKVQKITQARS *PTGIVCVP*VCTGPKEQALQSPAVPFPGLTSA PQATWRELRRSGSLWALEFCICTFLYSQIRILH* KCRNHPLGQLQVAGLLTQPGYF*CILCWALYMV DSDCRV*VP*RAPSSLFPCLQGLVTGDSQTCSR GSPVNLEGGLVVSRPPLFSSCQLALQRGCIRSFH QHQGEGSHHSHPSHPCPCFVLLELRCCSVLCVK *SGIAVTCVSLMTRRSQASLPRLPLPWILSRAN CLLMSFSHFSSGCWSGSYSAGW*EFLIFLITDSR LCL*TAFLLLLMCRSLSLTHDQLILSFMNGAIS DRLRTS*PSLRLETTVMFSSNDCEVLSLTYWAS IFGDLFVCDRFCWVTAVC*NRLIEVISSHLKRNG TVK*EEWTKKKSSPRDKDGEEANIPQRI*THFG RWEVGWWVAAEQKRAEGEAGHTGRPWHGAESKS GSTERRGRAATLEVLCQSSRMVLLALTSLQWRWR SGEPGEELRTAPPTQ*EQHRAPGCRRGRGLHSE QFPRHWLPHQEAPTKQTKALEGQNALEQPRGQA WPSRLMAFWGSDRLCANPQRYHRHYLILGHFITL QRNLPLAVTVPSRSAPDSQP*TYLLSL*ICLLR TFM*MWPLLLLSKIFSWFLCVAACIGVSFLLMA E*SLVWMHHTLFIHSSVAGHLGGFYFLATLKMLL *TFVNKFLWGR

Frame 1

GSWAGP*FRARCDRWGFVRGGHSSHGCS*RDPP WLPGVATARLLQDPPGDQAGSQVPVLRLQKRPP QALPGAVWPPVLLLLPGQHPQLWASELCCLCSRG HI*RRHFYFRKQFGLPR*CCPQGGGEPAGRLSQ *WMHLEGDPERIRGKDACVWHGDRSSSSRESST LPKQL*PCPARSSHWG*SLSDVCGGRDGAAP*KL PRRPLPAHADRMSRVQRPGPPW*KGAPPGARVP GEKPELPALPGTLLRSRREGAPRGLPQVPLNL* RLRQEEDPPGEAGPRQD*SPE*QGAAAGEEHWPQ GPGDG*LGAEGLGDGGIHLRWGLHLEDLRLRQE APGSCGWPHTRHLLPSLLHQQVRLQDVSAYLPE RRRHRARNTPVPLLCGDEGPE*RPAAVALQPEGD LNAARPE*PGARD*RLQARRDFILFSEASQRHE HRKRLPPLLPRLQDGGKEFLRAGRCHLHQGHCG PDRALTAPYWCLGVGGSQAQPAHGGATTLGQGLT VQVGRGRAWALGRVSACSQVHCHGGRSHQPVLR FQRLRRGLADGLSQGLWWHWPRVFGCFPAQAAL AVLCSEGRGPGWGTLRVGAHPSSAHVAGAQWMAL CPSGMTGRNEGCSRRRASCWPEQGRLSSLVLPS GPWREGSIPRPLGACLHRALVCATLARLAVGEG LVPRRLCSDHCVGGAQHSLRVKCESLPSSSRRQS Y*TIQISVVSGIHLIPGCLRLPALAVVTLCGSS WPLLSQTPPHGVPSPCLLL*LARLCSLFLT*CK LPLLEPCSLFWNVLPCPSPLLGLPRDSCESRMRM SQPWSCLSVHRLHRASWLHPGGPGHTEGPGCTA PVVCFWDSAGRRRHGFTLGVRAAVLGPTGHLYR GPG*SAVPSRRLHALL*FEKLTTEKYRK*LRHGA DRRALSVFRECVLGLKSKHCRALLFPFPASPQL PRPRGGN*GVPVLFGL*NFASVRFCIHK*EYCI KNAETIHWVSCR*LGF*LSLATFNASCAGHSTWW ILTAVCEFPREHLPVSSRVFRVW*LEIARPALV GLLSTWKEGWWFLGLPFLAVASLLCRGAASGPS TSTRGRVPITPIPPIPARASCCWN*DAAACCV*S EVASLSRAFL**LGGVRRLYHAYLSLGFSPVRI AC*CLFLIFLLVVGLGLILLVGRSS*YS*LRIL GCVFELRFCCS*CAEA*ALHMIS*SYPL*MVLFP TDSEHPDLP*GWKPLSCFRLMIVKFCL*HTGLL YLGICLYVTGFAGSLQFVKTD*LRSSLLT*NEM EL*NERNGPKKNPPPGTKMGKKPTSHKGFEPILE GGKWVGGWLLSRRGLRGKLATPGGPGMEQSLKV DQLKDGAEQLPWRSFARAAGWSSWPSPPCSGDG GLENLGKS*GPHPPRSESSIGLQAAEGAEVCTRN NSLGTGCHTKRLPRSRPRPLRDKMLWSSPVGRP GPAASWPSGEVTGSVQTHRGTIVTT*FWDISSP CRETFP*QSLFPPAQPLTASHKPTFCLYRFAYSG HSCECGLCFYSARYFHGSCVLQHALEFHSF*WL NNLLYGCTTPYLSIHPLLDIWVVSTFWLL*KCC CEHL*TSFYGDV

Frame 2

VAGRALSSGRAATVGALFAGVTALMAAASVTPP GSLELLQPGFSKTLLGTKLEAKYLCSACRNVLR RPFQAQCGHRYCSFCLASILSSGPQNCAACVHE GIYEEGISILESSSAFPDNAARREVESLPAVCPS DGCTWKGTLKEYEVKMPACGMVTEAPAVGSRPR SPSSYDLVLHVPLTGAEACLMSVEEETELLLRS CHEGRCPLMLTECPACKGLVRLGEKERHLEHECP ERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCD GCGKKKIPREKLDQDKIEALSSKVQQLERSIGL KDLAMADLEQKVLEMEASTYDGVFIWKISDFARK RQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLN GDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKV TLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMN IASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVD LTGL*LPPTGVWGLGAARHSRLTEGPPRWARVS LYKWAGAALGRLGGCRPAAKFTVTGEGATSQSSD FRDCGGAWQTVLAKGCGGIGRGSSGASQHKLPL LSCAVKGEALGGGHSEWEHIPAVPM*QEHSGWP CVPRA*QAETRAAPGEGPPAGQSKEG*AAWFSPL APGEKGAFLDPWVLVCTELWSVPPWPGWLWERV WSHAASAQTTVWEVHSTACG*SVRACHPAHEDR VIKPFKSLWSVASI*FQVACGFQPWQW*PSAGPP GLSSHRPLPTGCLAPACFSS*PGCVLCSSPDVS SLFSSLVPSSGMFFPVHLLSWASPGTPVRAE*G *ASPGPAFLCTGSTEHPGCTRGVLATPRVLAAPP LWCVFGTVQAGVGTASHSVSGQPCWDLLGICIG VQDKVLSPLDVFTHCCSLRS*PQKSTENNSGTE LTDGHCLCSVSVYWA*RASIAEPCCSLSRPHLSS PGHVAGIEAFRFSLGFRILHLYVSVFTNKNIAL KMQKPSTGSAAGSWAFDSAWLLLMHLVLGTLHG GF*LPCVSSLESTFQSLPVSSGFGDWR*PDLLSW VSCQPGRRVGGF*ASPF*QLPACFAEGLHPVLP PAPGGGFPSLPSLPSLPVLRVVGIEMLQRAVCE VKWHRCHVRFSDDSAESGVFTTLTSPLDSLPCEL PVDVFFSFFFWLLVWVLFCWLVGVPDIPDYGFS VVSLNCVSVAPDVQKLKPYT*SADLILYEWCYF RPTQNILTFPEAGNHCHVFV**L*SFVFNILGFY IWGFVCM*QVLLGHCSLLKQID*GHLFSLKTKW NCEMRGMDQKKILPQGQRWGRSQHPTKDLNPFW KVGSGLVGGC*AEEG*GGSWPHREALAWSRV*KW IN*KTGQSSYLGGPLPEQPDGPPGPHLPAVEME VWRTWGRAEDRTPHAVRAASGSRLQKGQRSALG TIP*ALAATPRGSHEADQGP*GTKCSGAAPWAGL AQPPHGLLGK*QALCKPTEVPSSLPNFGTFHHP AEKPSLSSHCSLPLSP*QPAINLPSVSIDLPTQ DIHVNVAFAFTQQDIFMVPVCCSMHWSFIPSNG* IISCMDAPHLIYPFIRCWTFGWFLLFGYSENAA VNICEQVFMGT

Sequence TRAF2.dAug05

TCGCCTAGGCCTCCCAAAGTGCTGGGATTACAGGCTGGTCTCGAACTCCTGGCCTGAAGTGATCCTCCAACCTCAGCCTCCCAAGTAGCTGGGATTACAG GTTGAATCGCTCCTAGCTGACCCCTCACGTCTCTTATGATACGTACAGAAAGCAAGAGCAGCCCATGCCGTCCGGCCGCGCACCAGGTCTCAGTCTGTGT GTCTGGTTCAGGTGACCATGGTGTTCAGTTCAGTTCCTCCTGCCTCGTGTGTAGGCCACTGAGAGCTCCCTAGTCTAAGCCGGAGGAGGTTCTGGGCTTT GTTCGCGGGGGTCACAGCTCTCATGGCTGCAGCTAGCGTGACCCCCCCTGGCTCCCTGGAGTTGCTACAGCCCGGCTTCTCCAAGACCCTCCTGGGGACC AAGCTGGAAGCCAAGTACCTGTGCTCCGCCTGCAGAAACGTCCTCCGCAGGCCCTTCCAGGCGCAGTGTGGCCACCGGTACTGCTCCTTCTGCCTGGCCA GCATCCTCAGCTCTGGGCCTCAGAACTGTGCTGCCTGTGTTCACGAGGGCATATATGAAGAAGGCATTTCTATTTTAGAAAGCAGTTCGGCCTTCCCAGA TAATGCTGCCCGCAGGGAGGTGGAGAGCCTGCCGGCCGTCTGTCCCAGTGATGGATGCACCTGGAAGGGGACCCTGAAAGAATACGAGAGCTGCCACGAA GGCCGCTGCCCGCTCATGCTGACCGAATGTCCCGCGTGCAAAGGCCTGGTCCGCCTTGGTGAAAAGGAGCGCCACCTGGAGCACGAGTGCCCGGAGAGAA GCCTGAGCTGCCGGCATTGCCGGGCACCCTGCTGCGGAGCAGACGTGAAGGCGCACCACGAGGTCTGCCCCAAGTTCCCCTTAACTTGTGACGGCTGCGG CAAGAAGAAGATCCCCCGGGAGAAGTTTCAGGACCACGTCAAGACTTGTGGCAAGTGTCGAGTCCCTTGCAGATTCCACGCCATCGGCTGCCTCGAGACG GTAGAGGGTGAGAAACAGCAGGAGCACGAGGTGCAGTGGCTGCGGGAGCACCTGGCCATGCTACTGAGCTCGGTGCTGGAGGCAAAGCCCCTCTTGGGAG ACCAGAGCCACGCGGGGTCAGAGCTCCTGCAGAGGTGCGAGAGCCTGGAGAAGAAGACGGCCACTTTTGAGAACATTGTCTGCGTCCTGAACCGGGAGGT GGAGAGGGTGGCCATGACTGCCGAGGCCTGCAGCCGGCAGCACCGGCTGGACCAAGACAAGATTGAAGCCCTGAGTAGCAAGGTGGTCTTGGCACCCGGC AGGTGCAGCAGCTGGAGAGGAGCATTGGCCTCAAGGACCTGGCGATGGCTGACTTGGAGCAGAAGGTCTTGGAGATGGAGGCATCCACCTACGATGGGGT CTTCATCTGGAAGATCTCAGACTTCGCCAGGAAGCGCCAGGAAGCTGTGGCTGGCCGCATACCCGCCATCTTCTCCCCAGCCTTCTACACCAGCAGGTAC GGCTACAAGATGTGTCTGCGTATCTACCTGAACGGCGACGGCACCGGGCGAGGAACACACCTGTCCCTCTTCTTTGTGGTGATGAAGGGCCCGAATGACG CCCTGCTGCGGTGGCCCTTCAACCAGAAGGTGACCTTAATGCTGCTCGACCAGAATAACCGGGAGCACGTGATTGACGCCTTCAGGCCCGACGTGACTTC ATCCTCTTTTCAGAGGCCAGTCAACGACATGAACATCGCAAGCGGCTGCCCCCTCTTCTGCCCCGTCTCCAAGATGGAGGCAAAGAATTCCTACGTGCGG GACGATGCCATCTTCATCAAGGCCATTGTGGACCTGACAGGGCTCTAACTGCCCCCTACTGGTGTCTGGGGGTTGGGGGCAGCCAGGCACAGCCGGCTCA CGGAGGGGCCACCACGCTGGGCCAGGGTCTCACTGTACAAGTGGGCAGGGGCCGCGCTTGGGCGCTTGGGAGGGTGTCGGCCTGCAGCCAAGTTCACTGT CACGGGGGAAGGAGCCACCAGCCAGTCCTCAGATTTCAGAGACTGCGGAGGGGCTTGGCAGACGGTCTTAGCCAAGGGCTGTGGTGGCATTGGCCGAGGG TCTTCGGGTGCTTCCCAGCACAAGCTGCCCTTGCTGTCCTGTGCAGTGAAGGGAGAGGCCCTGGGTGGGGGACACTCAGAGTGGGAGCACATCCCAGCAG TGCCCATGTAGCAGGAGCACAGTGGATGGCCTTGTGTCCCTCGGGCATGACAGGCAGAAACGAGGGCTGCTCCAGGAGAAGGGCCTCCTGCTGGCCAGAG CAAGGAAGGCTGAGCAGCTTGGTTCTCCCCTCTGGCCCCTGGAGAGAAGGGAGCATTCCTAGACCCCTGGGTGCTTGTCTGCACAGAGCTCTGGTCTGTG CCACCTTGGCCAGGCTGGCTGTGGGAGAGGGTCTGGTCCCACGCCGCCTCTGCTCAGACCACTGTGTGGGAGGTGCACAGCACAGCCTGCGGGTAAAGTG TGAGAGCTTGCCATCCAGCTCACGAAGACAGAGTTATTAAACCATTCAAATCTCTGTGGTCAGTGGCATCCATTTGATTCCAGGTTGCCTGCGGCTTCCA GCCTTGGCAGTGGTGACCCTCTGCGGGTCCTCCTGGCCTCTCCTCTCACAGACCCCTCCCCACGGGGTGCCTAGCCCCTGCCTGCTTCTCTAGCTAGCCA GGCTGTGTTCTCTGTTCCTCACCTGATGTAAGCTCCCTCTTCTCGAGCCTTGTTCCCTCTTCTGGAATGTTCTTCCCTGTCCATCTCCTCTCCTGGGCCT CCCCAGGGACTCCTGTGAGAGCAGAATGAGGATGAGCCAGCCCTGGTCCTGCCTTTCTGTGCACAGGCTCCACCGAGCATCCTGGCTGCACCCGGGGGGT CCTGGCCACACCGAGGGTCCTGGCTGCACCGCCCCTGTGGTGTGTTTTTGGGACAGTGCAGGCAGGCGTAGGCACGGCTTCACACTCGGTGTCAGGGCAG CCGTGCTGGGACCTACTGGGCATCTGTATCGGGGTCCAGGATAAAGTGCTGTCCCCTCTCGACGTCTTCACGCACTGCTGTAGTTTGAGAAGTTGACCAC AGAAAAGTACAGAAAATAACTCAGGCACGGAGCTGACCGACGGGCATTGTCTGTGTTCCGTGAGTGTGTACTGGGCCTAAAGAGCAAGCATTGCAGAGCC CTGCTGTTCCCTTTCCCGGCCTCACCTCAGCTCCCCAGGCCACGTGGCGGGAATTGAGGCGTTCCGGTTCTCTTTGGGCTTTAGAATTTTGCATCTGTAC GTTTCTGTATTCACAAATAAGAATATTGCATTAAAAATGCAGAAACCATCCACTGGGTCAGCTGCAGGTAGCTGGGCTTTTGACTCAGCCTGGCTACTTT TAATGCATCTTGTGCTGGGCACTCTACATGGTGGATTCTGACTGCCGTGTGTGAGTTCCCTAGAGAGCACCTTCCAGTCTCTTCCCGTGTCTTCAGGGTT TGGTGACTGGAGATAGCCAGACCTGCTCTCGTGGGTCTCCTGTCAACCTGGAAGGAGGGTTGGTGGTTTCTAGGCCTCCCCTTTTTAGCAGTTGCCAGCT TGCTTTGCAGAGGGGCTGCATCCGGTCCTTCCACCAGCACCAGGGGGAGGGTTCCCATCACTCCCATCCCTCCCATCCCTGCCCGTGCTTCGTGTTGTTG GAATTGAGATGCTGCAGCGTGCTGTGTGTGAAGTGAAGTGGCATCGCTGTCACGTGCGTTTCTCTGATGACTCGGCGGAGTCAGGCGTCTTTACCACGCT TACCTCTCCCTTGGATTCTCTCCCGTGCGAATTGCCTGTTGATGTCTTTTTCTCATTTTTCTTCTGGTTGTTGGTCTGGGTCTTATTCTGCTGGTTGGTA GGAGTTCCTGATATTCCTGATTACGGATTCTCGGTTGTGTCTTTGAACTGCGTTTCTGTTGCTCCTGATGTGCAGAAGCTTAAGCCTTACACATGATCAG CTGATCTTATCCTTTATGAATGGTGCTATTTCCGACCGACTCAGAACATCCTGACCTTCCCTGAGGCTGGAAACCACTGTCATGTTTTCGTCTAATGATT GTGAAGTTTTGTCTTTAACATACTGGGCTTCTATATTTGGGGATTTGTTTGTATGTGACAGGTTTTGCTGGGTCACTGCAGTTTGTTAAAACAGATTGAT TGAGGTCATCTCTTCTCACTTAAAACGAAATGGAACTGTGAAATGAGAGGAATGGACCAAAAAAAAATCCTCCCCCAGGGACAAAGATGGGGAAGAAGCC AACATCCCACAAAGGATTTGAACCCATTTTGGAAGGTGGGAAGTGGGTTGGTGGGTGGCTGCTGAGCAGAAGAGGGCTGAGGGGGAAGCTGGCCACACCG GGAGGCCCTGGCATGGAGCAGAGTCTAAAAGTGGATCAACTGAAAGACGGGGCAGAGCAGCTACCTTGGAGGTCCTTTGCCAGAGCAGCCGGATGGTCCT CCTGGCCCTCACCTCCCTGCAGTGGAGATGGAGGTCTGGAGAACCTGGGGAAGAGCTGAGGACCGCACCCCCCACGCAGTGAGAGCAGCATCGGGCTCCA GGCTGCAGAAGGGGCAGAGGTCTGCACTCGGAACAATTCCCTAGGCACTGGCTGCCACACCAAGAGGCTCCCACGAAGCAGACCAAGGCCCTTGAGGGAC AAAATGCTCTGGAGCAGCCCCGTGGGCAGGCCTGGCCCAGCCGCCTCATGGCCTTCTGGGGAAGTGACAGGCTCTGTGCAAACCCACAGAGGTACCATCG TCACTACCTAATTTTGGGACATTTCATCACCCTGCAGAGAAACCTTCCCTTAGCAGTCACTGTTCCCTCCCGCTCAGCCCCTGACAGCCAGCCATAAACC TACCTTCTGTCTCTATAGATTTGCCTACTCAGGACATTCATGTGAATGTGGCCTTTGCTTTTACTCAGCAAGATATTTTCATGGTTCCTGTGTGTTGCAG CATGCATTGGAGTTTCATTCCTTCTAATGGCTGAATAATCTCTTGTATGGATGCACCACACCTTATTTATCCATTCATCCGTTGCTGGACATTTGGGTGG TTTCTACTTTTTGGCTACTCTGAAAATGCTGCTGTGAACATTTGTGAACAAGTTTTTATGGGGACGTG

TRAF2-3 (forward primer)
TRAF2-4 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

SPRPPKVLGLQAGLELLA*SDPPTSASQVAGIT G*IAPS*PLTSLMIRTESKSSPCRPAAHQVSVCV SGSGDHGVQFSSSCLVCRPLRAP*SKPEEVLGF VRGGHSSHGCS*RDPPWLPGVATARLLQDPPGD QAGSQVPVLRLQKRPPQALPGAVWPPVLLLLPGQ HPQLWASELCCLCSRGHI*RRHFYFRKQFGLPR *CCPQGGGEPAGRLSQ*WMHLEGDPERIRELPR RPLPAHADRMSRVQRPGPPW*KGAPPGARVPGEK PELPALPGTLLRSRREGAPRGLPQVPLNL*RLR QEEDPPGEVSGPRQDLWQVSSPLQIPRHRLPRD GRG*ETAGARGAVAAGAPGHATELGAGGKAPLGR PEPRGVRAPAEVREPGEEDGHF*EHCLRPEPGG GEGGHDCRGLQPAAPAGPRQD*SPE*QGGLGTR QVQQLERSIGLKDLAMADLEQKVLEMEASTYDGV FIWKISDFARKRQEAVAGRIPAIFSPAFYTSRY GYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPND ALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTS SSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVR DDAIFIKAIVDLTGL*LPPTGVWGLGAARHSRL TEGPPRWARVSLYKWAGAALGRLGGCRPAAKFTV TGEGATSQSSDFRDCGGAWQTVLAKGCGGIGRG SSGASQHKLPLLSCAVKGEALGGGHSEWEHIPA VPM*QEHSGWPCVPRA*QAETRAAPGEGPPAGQS KEG*AAWFSPLAPGEKGAFLDPWVLVCTELWSV PPWPGWLWERVWSHAASAQTTVWEVHSTACG*S VRACHPAHEDRVIKPFKSLWSVASI*FQVACGFQ PWQW*PSAGPPGLSSHRPLPTGCLAPACFSS*P GCVLCSSPDVSSLFSSLVPSSGMFFPVHLLSWA SPGTPVRAE*G*ASPGPAFLCTGSTEHPGCTRGV LATPRVLAAPPLWCVFGTVQAGVGTASHSVSGQ PCWDLLGICIGVQDKVLSPLDVFTHCCSLRS*P QKSTENNSGTELTDGHCLCSVSVYWA*RASIAEP CCSLSRPHLSSPGHVAGIEAFRFSLGFRILHLY VSVFTNKNIALKMQKPSTGSAAGSWAFDSAWLL LMHLVLGTLHGGF*LPCVSSLESTFQSLPVSSGF GDWR*PDLLSWVSCQPGRRVGGF*ASPF*QLPA CFAEGLHPVLPPAPGGGFPSLPSLPSLPVLRVV GIEMLQRAVCEVKWHRCHVRFSDDSAESGVFTTL TSPLDSLPCELPVDVFFSFFFWLLVWVLFCWLV GVPDIPDYGFSVVSLNCVSVAPDVQKLKPYT*S ADLILYEWCYFRPTQNILTFPEAGNHCHVFV**L *SFVFNILGFYIWGFVCM*QVLLGHCSLLKQID *GHLFSLKTKWNCEMRGMDQKKILPQGQRWGRS QHPTKDLNPFWKVGSGLVGGC*AEEG*GGSWPHR EALAWSRV*KWIN*KTGQSSYLGGPLPEQPDGP PGPHLPAVEMEVWRTWGRAEDRTPHAVRAASGS RLQKGQRSALGTIP*ALAATPRGSHEADQGP*GT KCSGAAPWAGLAQPPHGLLGK*QALCKPTEVPS SLPNFGTFHHPAEKPSLSSHCSLPLSP*QPAIN LPSVSIDLPTQDIHVNVAFAFTQQDIFMVPVCCS MHWSFIPSNG*IISCMDAPHLIYPFIRCWTFGW FLLFGYSENAAVNICEQVFMGT

Frame 1

RLGLPKCWDYRLVSNSWPEVILQPQPPK*LGLQ VESLLADPSRLL*YVQKARAAHAVRPRTRSQSV CLVQVTMVFSSVPPASCVGH*ELPSLSRRRFWAL FAGVTALMAAASVTPPGSLELLQPGFSKTLLGT KLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLA SILSSGPQNCAACVHEGIYEEGISILESSSAFPD NAARREVESLPAVCPSDGCTWKGTLKEYESCHE GRCPLMLTECPACKGLVRLGEKERHLEHECPER SLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCG KKKIPREKFQDHVKTCGKCRVPCRFHAIGCLET VEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLG DQSHAGSELLQRCESLEKKTATFENIVCVLNREV ERVAMTAEACSRQHRLDQDKIEALSSKVVLAPG RCSSWRGALASRTWRWLTWSRRSWRWRHPPTMG SSSGRSQTSPGSARKLWLAAYPPSSPQPSTPAGT ATRCVCVST*TATAPGEEHTCPSSLW**RARMT PCCGGPSTRR*P*CCSTRITGST*LTPSGPT*L HPLFRGQSTT*TSQAAAPSSAPSPRWRQRIPTCG TMPSSSRPLWT*QGSNCPLLVSGGWGQPGTAGS RRGHHAGPGSHCTSGQGPRLGAWEGVGLQPSSL SRGKEPPASPQISETAEGLGRRS*PRAVVALAEG LRVLPSTSCPCCPVQ*RERPWVGDTQSGSTSQQ CPCSRSTVDGLVSLGHDRQKRGLLQEKGLLLAR ARKAEQLGSPLWPLERREHS*TPGCLSAQSSGLC HLGQAGCGRGSGPTPPLLRPLCGRCTAQPAGKV *ELAIQLTKTELLNHSNLCGQWHPFDSRLPAAS SLGSGDPLRVLLASPLTDPSPRGA*PLPASLASQ AVFSVPHLM*APSSRALFPLLECSSLSISSPGP PQGLL*EQNEDEPALVLPFCAQAPPSILAAPGG SWPHRGSWLHRPCGVFLGQCRQA*ARLHTRCQGS RAGTYWASVSGSRIKCCPLSTSSRTAVV*EVDH RKVQKITQARS*PTGIVCVP*VCTGPKEQALQS PAVPFPGLTSAPQATWRELRRSGSLWALEFCICT FLYSQIRILH*KCRNHPLGQLQVAGLLTQPGYF *CILCWALYMVDSDCRV*VP*RAPSSLFPCLQG LVTGDSQTCSRGSPVNLEGGLVVSRPPLFSSCQL ALQRGCIRSFHQHQGEGSHHSHPSHPCPCFVLL ELRCCSVLCVK*SGIAVTCVSLMTRRSQASLPR LPLPWILSRANCLLMSFSHFSSGCWSGSYSAGW* EFLIFLITDSRLCL*TAFLLLLMCRSLSLTHDQ LILSFMNGAISDRLRTS*PSLRLETTVMFSSND CEVLSLTYWASIFGDLFVCDRFCWVTAVC*NRLI EVISSHLKRNGTVK*EEWTKKKSSPRDKDGEEA NIPQRI*THFGRWEVGWWVAAEQKRAEGEAGHT GRPWHGAESKSGSTERRGRAATLEVLCQSSRMVL LALTSLQWRWRSGEPGEELRTAPPTQ*EQHRAP GCRRGRGLHSEQFPRHWLPHQEAPTKQTKALEG QNALEQPRGQAWPSRLMAFWGSDRLCANPQRYHR HYLILGHFITLQRNLPLAVTVPSRSAPDSQP*T YLLSL*ICLLRTFM*MWPLLLLSKIFSWFLCVA ACIGVSFLLMAE*SLVWMHHTLFIHSSVAGHLGG FYFLATLKMLL*TFVNKFLWGR

Frame 2

A*ASQSAGITGWSRTPGLK*SSNLSLPSSWDYR LNRS*LTPHVSYDTYRKQEQPMPSGRAPGLSLC VWFR*PWCSVQFLLPRV*ATESSLV*AGGGSGL CSRGSQLSWLQLA*PPLAPWSCYSPASPRPSWGP SWKPSTCAPPAETSSAGPSRRSVATGTAPSAWP ASSALGLRTVLPVFTRAYMKKAFLF*KAVRPSQ IMLPAGRWRACRPSVPVMDAPGRGP*KNTRAATK AAARSC*PNVPRAKAWSALVKRSATWSTSARRE A*AAGIAGHPAAEQT*RRTTRSAPSSP*LVTAA ARRRSPGRSFRTTSRLVASVESLADSTPSAASRR *RVRNSRSTRCSGCGSTWPCY*ARCWRQSPSWE TRATRGQSSCRGARAWRRRRPLLRTLSAS*TGR WRGWP*LPRPAAGSTGWTKTRLKP*VARWSWHPA GAAAGEEHWPQGPGDG*LGAEGLGDGGIHLRWG LHLEDLRLRQEAPGSCGWPHTRHLLPSLLHQQV RLQDVSAYLPERRRHRARNTPVPLLCGDEGPE*R PAAVALQPEGDLNAARPE*PGARD*RLQARRDF ILFSEASQRHEHRKRLPPLLPRLQDGGKEFLRA GRCHLHQGHCGPDRALTAPYWCLGVGGSQAQPAH GGATTLGQGLTVQVGRGRAWALGRVSACSQVHC HGGRSHQPVLRFQRLRRGLADGLSQGLWWHWPR VFGCFPAQAALAVLCSEGRGPGWGTLRVGAHPSS AHVAGAQWMALCPSGMTGRNEGCSRRRASCWPE QGRLSSLVLPSGPWREGSIPRPLGACLHRALVC ATLARLAVGEGLVPRRLCSDHCVGGAQHSLRVKC ESLPSSSRRQSY*TIQISVVSGIHLIPGCLRLP ALAVVTLCGSSWPLLSQTPPHGVPSPCLLL*LA RLCSLFLT*CKLPLLEPCSLFWNVLPCPSPLLGL PRDSCESRMRMSQPWSCLSVHRLHRASWLHPGG PGHTEGPGCTAPVVCFWDSAGRRRHGFTLGVRA AVLGPTGHLYRGPG*SAVPSRRLHALL*FEKLTT EKYRK*LRHGADRRALSVFRECVLGLKSKHCRA LLFPFPASPQLPRPRGGN*GVPVLFGL*NFASV RFCIHK*EYCIKNAETIHWVSCR*LGF*LSLATF NASCAGHSTWWILTAVCEFPREHLPVSSRVFRV W*LEIARPALVGLLSTWKEGWWFLGLPFLAVAS LLCRGAASGPSTSTRGRVPITPIPPIPARASCCW N*DAAACCV*SEVASLSRAFL**LGGVRRLYHA YLSLGFSPVRIAC*CLFLIFLLVVGLGLILLVG RSS*YS*LRILGCVFELRFCCS*CAEA*ALHMIS *SYPL*MVLFPTDSEHPDLP*GWKPLSCFRLMI VKFCL*HTGLLYLGICLYVTGFAGSLQFVKTD* LRSSLLT*NEMEL*NERNGPKKNPPPGTKMGKKP TSHKGFEPILEGGKWVGGWLLSRRGLRGKLATP GGPGMEQSLKVDQLKDGAEQLPWRSFARAAGWS SWPSPPCSGDGGLENLGKS*GPHPPRSESSIGLQ AAEGAEVCTRNNSLGTGCHTKRLPRSRPRPLRD KMLWSSPVGRPGPAASWPSGEVTGSVQTHRGTI VTT*FWDISSPCRETFP*QSLFPPAQPLTASHKP TFCLYRFAYSGHSCECGLCFYSARYFHGSCVLQ HALEFHSF*WLNNLLYGCTTPYLSIHPLLDIWV VSTFWLL*KCCCEHL*TSFYGDV

Sequence TRAF2.aAug05

CGGTAGCTGGGCGGGCCCTTAGTTCCGGGCGCGCTGCGACCGTTGGGGCTTTGTTCGCGGGGGTCACAGCTCTCATGGCTGCAGCTAGCGTGACCCCCCC TGGCTCCCTGGAGTTGCTACAGCCCGGCTTCTCCAAGACCCTCCTGGGGACCAAGCTGGAAGCCAAGTACCTGTGCTCCGCCTGCAGAAACGTCCTCCGC AGGCCCTTCCAGGCGCAGTGTGGCCACCGGTACTGCTCCTTCTGCCTGGCCAGCATCCTCAGCTCTGGGCCTCAGAACTGTGCTGCCTGTGTTCACGAGG GCATATATGAAGAAGGCATTTCTATTTTAGAAAGCAGTTCGGCCTTCCCAGATAATGCTGCCCGCAGGGAGGTGGAGAGCCTGCCGGCCGTCTGTCCCAG TGATGGATGCACCTGGAAGGGGACCCTGAAAGAATACGAGAGCTGCCACGAAGGCCGCTGCCCGCTCATGCTGACCGAATGTCCCGCGTGCAAAGGCCTG GTCCGCCTTGGTGAAAAGGAGCGCCACCTGGAGCACGAGTGCCCGGAGAGAAGCCTGAGCTGCCGGCATTGCCGGGCACCCTGCTGCGGAGCAGACGTGA AGGCGCACCACGAGGTCTGCCCCAAGTTCCCCTTAACTTGTGACGGCTGCGGCAAGAAGAAGATCCCCCGGGAGAAGTTTCAGGACCACGTCAAGACTTG TGGCAAGTGTCGAGTCCCTTGCAGATTCCACGCCATCGGCTGCCTCGAGACGGTAGAGGGTGAGAAACAGCAGGAGCACGAGGTGCAGTGGCTGCGGGAG CACCTGGCCATGCTACTGAGCTCGGTGCTGGAGGCAAAGCCCCTCTTGGGAGACCAGAGCCACGCGGGGTCAGAGCTCCTGCAGAGGTGCGAGAGCCTGG AGAAGAAGACGGCCACTTTTGAGAACATTGTCTGCGTCCTGAACCGGGAGGTGGAGAGGGTGGCCATGACTGCCGAGGCCTGCAGCCGGCAGCACCGGCT GGACCAAGACAAGATTGAAGCCCTGAGTAGCAAGGTGCAGCAGCTGGAGAGGAGCATTGGCCTCAAGGACCTGGCGATGGCTGACTTGGAGCAGAAGGTC TTGGAGATGGAGGCATCCACCTACGATGGGGTCTTCATCTGGAAGATCTCAGACTTCGCCAGGAAGCGCCAGGAAGCTGTGGCTGGCCGCATACCCGCCA TCTTCTCCCCAGCCTTCTACACCAGCAGGTACGGCTACAAGATGTGTCTGCGTATCTACCTGAACGGCGACGGCACCGGGCGAGGAACACACCTGTCCCT CTTCTTTGTGGTGATGAAGGGCCCGAATGACGCCCTGCTGCGGTGGCCCTTCAACCAGAAGGTGACCTTAATGCTGCTCGACCAGAATAACCGGGAGCAC GTGATTGACGCCTTCAGGCCCGACGTGACTTCATCCTCTTTTCAGAGGCCAGTCAACGACATGAACATCGCAAGCGGCTGCCCCCTCTTCTGCCCCGTCT CCAAGATGGAGGCAAAGAATTCCTACGTGCGGGACGATGCCATCTTCATCAAGGCCATTGTGGACCTGACAGGGCTCTAACTGCCCCCTACTGGTGTCTG GGGGTTGGGGGCAGCCAGGCACAGCCGGCTCACGGAGGGGCCACCACGCTGGGCCAGGGTCTCACTGTACAAGTGGGCAGGGGCCGCGCTTGGGCGCTTG GGAGGGTGTCGGCCTGCAGCCAAGTTCACTGTCACGGGGGAAGGAGCCACCAGCCAGTCCTCAGATTTCAGAGACTGCGGAGGGGCTTGGCAGACGGTCT TAGCCAAGGGCTGTGGTGGCATTGGCCGAGGGTCTTCGGGTGCTTCCCAGCACAAGCTGCCCTTGCTGTCCTGTGCAGTGAAGGGAGAGGCCCTGGGTGG GGGACACTCAGAGTGGGAGCACATCCCAGCAGTGCCCATGTAGCAGGAGCACAGTGGATGGCCTTGTGTCCCTCGGGCATGACAGGCAGAAACGAGGGCT GCTCCAGGAGAAGGGCCTCCTGCTGGCCAGAGCAAGGAAGGCTGAGCAGCTTGGTTCTCCCCTCTGGCCCCTGGAGAGAAGGGAGCATTCCTAGACCCCT GGGTGCTTGTCTGCACAGAGCTCTGGTCTGTGCCACCTTGGCCAGGCTGGCTGTGGGAGAGGGTCTGGTCCCACGCCGCCTCTGCTCAGACCACTGTGTG GGAGGTGCACAGCACAGCCTGCGGGTAAAGTGTGAGAGCTTGCCATCCAGCTCACGAAGACAGAGTTATTAAACCATTCAAATCTCTGTGGTCAGTGGCA TCCATTTGATTCCAGGTTGCCTGCGGCTTCCAGCCTTGGCAGTGGTGACCCTCTGCGGGTCCTCCTGGCCTCTCCTCTCACAGACCCCTCCCCACGGGGT GCCTAGCCCCTGCCTGCTTCTCTAGCTAGCCAGGCTGTGTTCTCTGTTCCTCACCTGATGTAAGCTCCCTCTTCTCGAGCCTTGTTCCCTCTTCTGGAAT GTTCTTCCCTGTCCATCTCCTCTCCTGGGCCTCCCCAGGGACTCCTGTGAGAGCAGAATGAGGATGAGCCAGCCCTGGTCCTGCCTTTCTGTGCACAGGC TCCACCGAGCATCCTGGCTGCACCCGGGGGGTCCTGGCCACACCGAGGGTCCTGGCTGCACCGCCCCTGTGGTGTGTTTTTGGGACAGTGCAGGCAGGCG TAGGCACGGCTTCACACTCGGTGTCAGGGCAGCCGTGCTGGGACCTACTGGGCATCTGTATCGGGGTCCAGGATAAAGTGCTGTCCCCTCTCGACGTCTT CACGCACTGCTGTAGTTTGAGAAGTTGACCACAGAAAAGTACAGAAAATAACTCAGGCACGGAGCTGACCGACGGGCATTGTCTGTGTTCCGTGAGTGTG TACTGGGCCTAAAGAGCAAGCATTGCAGAGCCCTGCTGTTCCCTTTCCCGGCCTCACCTCAGCTCCCCAGGCCACGTGGCGGGAATTGAGGCGTTCCGGT TCTCTTTGGGCTTTAGAATTTTGCATCTGTACGTTTCTGTATTCACAAATAAGAATATTGCATTAAAAATGCAGAAACCATCCACTGGGTCAGCTGCAGG TAGCTGGGCTTTTGACTCAGCCTGGCTACTTTTAATGCATCTTGTGCTGGGCACTCTACATGGTGGATTCTGACTGCCGTGTGTGAGTTCCCTAGAGAGC ACCTTCCAGTCTCTTCCCGTGTCTTCAGGGTTTGGTGACTGGAGATAGCCAGACCTGCTCTCGTGGGTCTCCTGTCAACCTGGAAGGAGGGTTGGTGGTT TCTAGGCCTCCCCTTTTTAGCAGTTGCCAGCTTGCTTTGCAGAGGGGCTGCATCCGGTCCTTCCACCAGCACCAGGGGGAGGGTTCCCATCACTCCCATC CCTCCCATCCCTGCCCGTGCTTCGTGTTGTTGGAATTGAGATGCTGCAGCGTGCTGTGTGTGAAGTGAAGTGGCATCGCTGTCACGTGCGTTTCTCTGAT GACTCGGCGGAGTCAGGCGTCTTTACCACGCTTACCTCTCCCTTGGATTCTCTCCCGTGCGAATTGCCTGTTGATGTCTTTTTCTCATTTTTCTTCTGGT TGTTGGTCTGGGTCTTATTCTGCTGGTTGGTAGGAGTTCCTGATATTCCTGATTACGGATTCTCGGTTGTGTCTTTGAACTGCGTTTCTGTTGCTCCTGA TGTGCAGAAGCTTAAGCCTTACACATGATCAGCTGATCTTATCCTTTATGAATGGTGCTATTTCCGACCGACTCAGAACATCCTGACCTTCCCTGAGGCT GGAAACCACTGTCATGTTTTCGTCTAATGATTGTGAAGTTTTGTCTTTAACATACTGGGCTTCTATATTTGGGGATTTGTTTGTATGTGACAGGTTTTGC TGGGTCACTGCAGTTTGTTAAAACAGATTGATTGAGGTCATCTCTTCTCACTTAAAACGAAATGGAACTGTGAAATGAGAGGAATGGACCAAAAAAAAAT CCTCCCCCAGGGACAAAGATGGGGAAGAAGCCAACATCCCACAAAGGATTTGAACCCATTTTGGAAGGTGGGAAGTGGGTTGGTGGGTGGCTGCTGAGCA GAAGAGGGCTGAGGGGGAAGCTGGCCACACCGGGAGGCCCTGGCATGGAGCAGAGTCTAAAAGTGGATCAACTGAAAGACGGGGCAGAGCAGCTACCTTG GAGGTCCTTTGCCAGAGCAGCCGGATGGTCCTCCTGGCCCTCACCTCCCTGCAGTGGAGATGGAGGTCTGGAGAACCTGGGGAAGAGCTGAGGACCGCAC CCCCCACGCAGTGAGAGCAGCATCGGGCTCCAGGCTGCAGAAGGGGCAGAGGTCTGCACTCGGAACAATTCCCTAGGCACTGGCTGCCACACCAAGAGGC TCCCACGAAGCAGACCAAGGCCCTTGAGGGACAAAATGCTCTGGAGCAGCCCCGTGGGCAGGCCTGGCCCAGCCGCCTCATGGCCTTCTGGGGAAGTGAC AGGCTCTGTGCAAACCCACAGAGGTACCATCGTCACTACCTAATTTTGGGACATTTCATCACCCTGCAGAGAAACCTTCCCTTAGCAGTCACTGTTCCCT CCCGCTCAGCCCCTGACAGCCAGCCATAAACCTACCTTCTGTCTCTATAGATTTGCCTACTCAGGACATTCATGTGAATGTGGCCTTTGCTTTTACTCAG CAAGATATTTTCATGGTTCCTGTGTGTTGCAGCATGCATTGGAGTTTCATTCCTTCTAATGGCTGAATAATCTCTTGTATGGATGCACCACACCTTATTT ATCCATTCATCCGTTGCTGGACATTTGGGTGGTTTCTACTTTTTGGCTACTCTGAAAATGCTGCTGTGAACATTTGTGAACAAGTTTTTATGGGGACGTG

TRAF2-3 (forward primer)
TRAF2-4 (reverse primer)
Exon skipping and alternative donor or acceptor

Frame 0

R*LGGPLVPGALRPLGLCSRGSQLSWLQLA*PP LAPWSCYSPASPRPSWGPSWKPSTCAPPAETSSA GPSRRSVATGTAPSAWPASSALGLRTVLPVFTR AYMKKAFLF*KAVRPSQIMLPAGRWRACRPSVP VMDAPGRGP*KNTRAATKAAARSC*PNVPRAKAW SALVKRSATWSTSARREA*AAGIAGHPAAEQT* RRTTRSAPSSP*LVTAAARRRSPGRSFRTTSRL VASVESLADSTPSAASRR*RVRNSRSTRCSGCGS TWPCY*ARCWRQSPSWETRATRGQSSCRGARAW RRRRPLLRTLSAS*TGRWRGWP*LPRPAAGSTG WTKTRLKP*VARCSSWRGALASRTWRWLTWSRRS WRWRHPPTMGSSSGRSQTSPGSARKLWLAAYPP SSPQPSTPAGTATRCVCVST*TATAPGEEHTCP SSLW**RARMTPCCGGPSTRR*P*CCSTRITGST *LTPSGPT*LHPLFRGQSTT*TSQAAAPSSAPS PRWRQRIPTCGTMPSSSRPLWT*QGSNCPLLVS GGWGQPGTAGSRRGHHAGPGSHCTSGQGPRLGAW EGVGLQPSSLSRGKEPPASPQISETAEGLGRRS *PRAVVALAEGLRVLPSTSCPCCPVQ*RERPWV GDTQSGSTSQQCPCSRSTVDGLVSLGHDRQKRGL LQEKGLLLARARKAEQLGSPLWPLERREHS*TP GCLSAQSSGLCHLGQAGCGRGSGPTPPLLRPLC GRCTAQPAGKV*ELAIQLTKTELLNHSNLCGQWH PFDSRLPAASSLGSGDPLRVLLASPLTDPSPRG A*PLPASLASQAVFSVPHLM*APSSRALFPLLE CSSLSISSPGPPQGLL*EQNEDEPALVLPFCAQA PPSILAAPGGSWPHRGSWLHRPCGVFLGQCRQA *ARLHTRCQGSRAGTYWASVSGSRIKCCPLSTS SRTAVV*EVDHRKVQKITQARS*PTGIVCVP*VC TGPKEQALQSPAVPFPGLTSAPQATWRELRRSG SLWALEFCICTFLYSQIRILH*KCRNHPLGQLQ VAGLLTQPGYF*CILCWALYMVDSDCRV*VP*RA PSSLFPCLQGLVTGDSQTCSRGSPVNLEGGLVV SRPPLFSSCQLALQRGCIRSFHQHQGEGSHHSH PSHPCPCFVLLELRCCSVLCVK*SGIAVTCVSLM TRRSQASLPRLPLPWILSRANCLLMSFSHFSSG CWSGSYSAGW*EFLIFLITDSRLCL*TAFLLLL MCRSLSLTHDQLILSFMNGAISDRLRTS*PSLRL ETTVMFSSNDCEVLSLTYWASIFGDLFVCDRFC WVTAVC*NRLIEVISSHLKRNGTVK*EEWTKKK SSPRDKDGEEANIPQRI*THFGRWEVGWWVAAEQ KRAEGEAGHTGRPWHGAESKSGSTERRGRAATL EVLCQSSRMVLLALTSLQWRWRSGEPGEELRTA PPTQ*EQHRAPGCRRGRGLHSEQFPRHWLPHQEA PTKQTKALEGQNALEQPRGQAWPSRLMAFWGSD RLCANPQRYHRHYLILGHFITLQRNLPLAVTVP SRSAPDSQP*TYLLSL*ICLLRTFM*MWPLLLLS KIFSWFLCVAACIGVSFLLMAE*SLVWMHHTLF IHSSVAGHLGGFYFLATLKMLL*TFVNKFLWGR

Frame 1

GSWAGP*FRARCDRWGFVRGGHSSHGCS*RDPP WLPGVATARLLQDPPGDQAGSQVPVLRLQKRPP QALPGAVWPPVLLLLPGQHPQLWASELCCLCSRG HI*RRHFYFRKQFGLPR*CCPQGGGEPAGRLSQ *WMHLEGDPERIRELPRRPLPAHADRMSRVQRP GPPW*KGAPPGARVPGEKPELPALPGTLLRSRRE GAPRGLPQVPLNL*RLRQEEDPPGEVSGPRQDL WQVSSPLQIPRHRLPRDGRG*ETAGARGAVAAG APGHATELGAGGKAPLGRPEPRGVRAPAEVREPG EEDGHF*EHCLRPEPGGGEGGHDCRGLQPAAPA GPRQD*SPE*QGAAAGEEHWPQGPGDG*LGAEG LGDGGIHLRWGLHLEDLRLRQEAPGSCGWPHTRH LLPSLLHQQVRLQDVSAYLPERRRHRARNTPVP LLCGDEGPE*RPAAVALQPEGDLNAARPE*PGA RD*RLQARRDFILFSEASQRHEHRKRLPPLLPRL QDGGKEFLRAGRCHLHQGHCGPDRALTAPYWCL GVGGSQAQPAHGGATTLGQGLTVQVGRGRAWAL GRVSACSQVHCHGGRSHQPVLRFQRLRRGLADGL SQGLWWHWPRVFGCFPAQAALAVLCSEGRGPGW GTLRVGAHPSSAHVAGAQWMALCPSGMTGRNEG CSRRRASCWPEQGRLSSLVLPSGPWREGSIPRPL GACLHRALVCATLARLAVGEGLVPRRLCSDHCV GGAQHSLRVKCESLPSSSRRQSY*TIQISVVSG IHLIPGCLRLPALAVVTLCGSSWPLLSQTPPHGV PSPCLLL*LARLCSLFLT*CKLPLLEPCSLFWN VLPCPSPLLGLPRDSCESRMRMSQPWSCLSVHR LHRASWLHPGGPGHTEGPGCTAPVVCFWDSAGRR RHGFTLGVRAAVLGPTGHLYRGPG*SAVPSRRL HALL*FEKLTTEKYRK*LRHGADRRALSVFREC VLGLKSKHCRALLFPFPASPQLPRPRGGN*GVPV LFGL*NFASVRFCIHK*EYCIKNAETIHWVSCR *LGF*LSLATFNASCAGHSTWWILTAVCEFPRE HLPVSSRVFRVW*LEIARPALVGLLSTWKEGWWF LGLPFLAVASLLCRGAASGPSTSTRGRVPITPI PPIPARASCCWN*DAAACCV*SEVASLSRAFL* *LGGVRRLYHAYLSLGFSPVRIAC*CLFLIFLLV VGLGLILLVGRSS*YS*LRILGCVFELRFCCS* CAEA*ALHMIS*SYPL*MVLFPTDSEHPDLP*G WKPLSCFRLMIVKFCL*HTGLLYLGICLYVTGFA GSLQFVKTD*LRSSLLT*NEMEL*NERNGPKKN PPPGTKMGKKPTSHKGFEPILEGGKWVGGWLLS RRGLRGKLATPGGPGMEQSLKVDQLKDGAEQLPW RSFARAAGWSSWPSPPCSGDGGLENLGKS*GPH PPRSESSIGLQAAEGAEVCTRNNSLGTGCHTKR LPRSRPRPLRDKMLWSSPVGRPGPAASWPSGEVT GSVQTHRGTIVTT*FWDISSPCRETFP*QSLFP PAQPLTASHKPTFCLYRFAYSGHSCECGLCFYS ARYFHGSCVLQHALEFHSF*WLNNLLYGCTTPYL SIHPLLDIWVVSTFWLL*KCCCEHL*TSFYGDV

Frame 2

VAGRALSSGRAATVGALFAGVTALMAAASVTPP GSLELLQPGFSKTLLGTKLEAKYLCSACRNVLR RPFQAQCGHRYCSFCLASILSSGPQNCAACVHE GIYEEGISILESSSAFPDNAARREVESLPAVCPS DGCTWKGTLKEYESCHEGRCPLMLTECPACKGL VRLGEKERHLEHECPERSLSCRHCRAPCCGADV KAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTC GKCRVPCRFHAIGCLETVEGEKQQEHEVQWLRE HLAMLLSSVLEAKPLLGDQSHAGSELLQRCESL EKKTATFENIVCVLNREVERVAMTAEACSRQHRL DQDKIEALSSKVQQLERSIGLKDLAMADLEQKV LEMEASTYDGVFIWKISDFARKRQEAVAGRIPA IFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSL FFVVMKGPNDALLRWPFNQKVTLMLLDQNNREH VIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPV SKMEAKNSYVRDDAIFIKAIVDLTGL*LPPTGVW GLGAARHSRLTEGPPRWARVSLYKWAGAALGRL GGCRPAAKFTVTGEGATSQSSDFRDCGGAWQTV LAKGCGGIGRGSSGASQHKLPLLSCAVKGEALGG GHSEWEHIPAVPM*QEHSGWPCVPRA*QAETRA APGEGPPAGQSKEG*AAWFSPLAPGEKGAFLDP WVLVCTELWSVPPWPGWLWERVWSHAASAQTTVW EVHSTACG*SVRACHPAHEDRVIKPFKSLWSVA SI*FQVACGFQPWQW*PSAGPPGLSSHRPLPTG CLAPACFSS*PGCVLCSSPDVSSLFSSLVPSSGM FFPVHLLSWASPGTPVRAE*G*ASPGPAFLCTG STEHPGCTRGVLATPRVLAAPPLWCVFGTVQAG VGTASHSVSGQPCWDLLGICIGVQDKVLSPLDVF THCCSLRS*PQKSTENNSGTELTDGHCLCSVSV YWA*RASIAEPCCSLSRPHLSSPGHVAGIEAFR FSLGFRILHLYVSVFTNKNIALKMQKPSTGSAAG SWAFDSAWLLLMHLVLGTLHGGF*LPCVSSLES TFQSLPVSSGFGDWR*PDLLSWVSCQPGRRVGG F*ASPF*QLPACFAEGLHPVLPPAPGGGFPSLPS LPSLPVLRVVGIEMLQRAVCEVKWHRCHVRFSD DSAESGVFTTLTSPLDSLPCELPVDVFFSFFFW LLVWVLFCWLVGVPDIPDYGFSVVSLNCVSVAPD VQKLKPYT*SADLILYEWCYFRPTQNILTFPEA GNHCHVFV**L*SFVFNILGFYIWGFVCM*QVL LGHCSLLKQID*GHLFSLKTKWNCEMRGMDQKKI LPQGQRWGRSQHPTKDLNPFWKVGSGLVGGC*A EEG*GGSWPHREALAWSRV*KWIN*KTGQSSYL GGPLPEQPDGPPGPHLPAVEMEVWRTWGRAEDRT PHAVRAASGSRLQKGQRSALGTIP*ALAATPRG SHEADQGP*GTKCSGAAPWAGLAQPPHGLLGK* QALCKPTEVPSSLPNFGTFHHPAEKPSLSSHCSL PLSP*QPAINLPSVSIDLPTQDIHVNVAFAFTQ QDIFMVPVCCSMHWSFIPSNG*IISCMDAPHLI YPFIRCWTFGWFLLFGYSENAAVNICEQVFMGT