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Sequences

Sequence AXIN1.bAug05

CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTGGCGGCTGGGC CCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGGGCCGCGCCCCCGCCGGGTCC CGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCT TGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAG TTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCC TCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGG GCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGC CATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAAT ATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGA AGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCT ATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGAT CCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGG GTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGG AGGAGCGGCTGAAGCGCGTGCGCATGGAGGAGGAAGGTGAGGACGGCGATCCATCGTCAGGGCCCCCAGGGCCGTGTCACAAGCTGCCTCCCGCCCCCGC TTGGCACCACTTCCCGCCCCGCTGTGTGGACATGGGCTGTGCCGGGCTCCGGGATGCACACGAGGAGAACCCTGAGAGCATCCTGGACGAGCACGTACAG CGTGTGCTGAGGACACCTGGCCGCCAGTCGCCTGGGCCTGGCCATCGCTCCCCGGACAGTGGGCACGTGGCCAAGATGCCAGTGGCACTGGGGGGTGCCG CCTCGGGGCACGGGAAGCACGTACCCAAGTCAGGGGCGAAGCTGGACGCGGCCGGCCTGCACCACCACCGACACGTCCACCACCACGTCCACCACAGCAC AGCCCGGCCCAAGGAGCAGGTGGAGGCCGAGGCCACCCGCAGGGCCCAGAGCAGCTTCGCCTGGGGCCTGGAACCACACAGCCATGGGGCAAGGTCCCGA GGCTACTCAGAGAGTGTTGGCGCTGCCCCCAACGCCAGTGATGGCCTCGCCCACAGTGGGAAGGTGGGCGTGGCGTGCAAAAGAAATGCCAAGAAGGCTG AGTCGGGGAAGAGCGCCAGCACCGAGGTGCCAGGTGCCTCGGAGGATGCGGAGAAGAACCAGAAAATCATGCAGTGGATCATTGAGGGGGAAAAGGAGAT CAGCAGGCACCGCAGGACCGGCCACGGGTCTTCGGGGACGAGGAAGCCACAGCCCCATGAGAACTCCAGACCCTTGTCCCTTGAGCACCCCTGGGCCGGC CCTCAGCTCCGGACCTCCGTGCAGCCCTCCCACCTCTTCATCCAAGACCCCACCATGCCACCCCACCCAGCTCCCAACCCCCTAACCCAGCTGGAGGAGG CGCGCCGACGTCTGGAGGAGGAAGAAAAGAGAGCCAGCCGAGCACCCTCCAAGCAGAGGACAAGATCGCAGAGGAAGGTGGGCGGCGGGAGTGCCCAGCC GTGTGACAGCATCGTTGTGGCGTACTACTTCTGCGGGGAACCCATCCCCTACCGCACCCTGGTGAGGGGCCGCGCTGTCACCCTGGGCCAGTTCAAGGAG CTGCTGACCAAAAAGGGCAGCTACAGATACTACTTCAAGAAAGTGAGCGACGAGTTTGACTGTGGGGTGGTGTTTGAGGAGGTTCGAGAGGACGAGGCCG TCCTGCCCGTCTTTGAGGAGAAGATCATCGGCAAAGTGGAGAAGGTGGACTGATAGGCTGGTGGGCTGGCCGCTGTGCCAGGCGAGGCCCTTGGCGGGCA CGGGTGTCACGGCCAGGCAGATGACCTCGTACTCAGGAGCCCGATGGGGAACAGTGTTGGGTGTACCACCCATCCCTGTGGTCTACCCGTGTCTAGAGGC AGGTAGGGGGTCCCTCCAAGTGGTCCACAAGCTTCTGTCCTGCCCCCAAGGAGGCAGCCTGGACCACTCCTCATAGCAATACTTGGAGGGCCCAGCCCAA GTGAGGCAGCCGAGGTCCCTGCTGCCAGCTTCAGGTGACCCCCCCCCATCCCCCGGCACCTCCCTTGGGCACGTGTGCTGGGATCTACTTTCCCTCTGGG ATTTGCCCACGTACCCAGGTCTGGGTGGGGCCCAGGCCCGGATGCAGAGGCCTGCAGGGCCTCTGTCAATTGTACGCGCCACCGAGTGCCTTCAACACAG CTTGTCTCTTGCCTGCCACTGTGTGAATCGGCGACGGAGCACTGCACCTGCCTCCAGCCGCCGGCTGTGCAGTCCTGGGTCCTCCTTTCTGAGGGCCCGT GTAAATATGTACATTTCTCAGGCTAGGCCAGCAGGGGCTGCCCGAGTCTGTTTTTCATGCGATGACACTTGTACAATTAATTATCTTTTCAAAGGTACTT GGATAATAATGAAATAAAACTGTTTTTGAACCTGC

AXIN1-3 (forward primer)
AXIN1-4 (reverse primer)
Single exon skipping

Frame 0

LGRRSWPLPPPEPAGVGPEPRPRGAGGWELAAG PLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGP ARRAAAERMGPDRAAPLREPGPGSRHHRARDRL IHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFP LDLGASFTEDAPRPPVPGEEGELVSTDPRPASYS FCSGKGVGIKGETSTATPRRSDLDLGYEPEGSA SPTPPYLKWAESLHSLLDDQDGISLFRTFLKQE GCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA IYRKYILDNNGIVSRQTKPATKSFIKGCIMKQL IDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE YTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETA APRVSSSRRYSEGREFRYGSWREPVNPYYVNAG YALAPATSANDSEQQSLSSDADTLSLTDSSVDGI PPYRIRKQHRREMQESVQVNGRVPLPHIPRTYR VPKEVRVEPQKFAEELIHRLEAVQRTREAEEKL EERLKRVRMEEEGEDGDPSSGPPGPCHKLPPAPA WHHFPPRCVDMGCAGLRDAHEENPESILDEHVQ RVLRTPGRQSPGPGHRSPDSGHVAKMPVALGGA ASGHGKHVPKSGAKLDAAGLHHHRHVHHHVHHST ARPKEQVEAEATRRAQSSFAWGLEPHSHGARSR GYSESVGAAPNASDGLAHSGKVGVACKRNAKKA ESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEI SRHRRTGHGSSGTRKPQPHENSRPLSLEHPWAG PQLRTSVQPSHLFIQDPTMPPHPAPNPLTQLEE ARRRLEEEEKRASRAPSKQRTRSQRKVGGGSAQP CDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKE LLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEA VLPVFEEKIIGKVEKVD**AGGLAAVPGEALGGH GCHGQADDLVLRSPMGNSVGCTTHPCGLPVSRG R*GVPPSGPQASVLPPRRQPGPLLIAILGGPSP SEAAEVPAASFR*PPPIPRHLPWARVLGSTFPLG FAHVPRSGWGPGPDAEACRASVNCTRHRVPSTQ LVSCLPLCESATEHCTCLQPPAVQSWVLLSEGP CKYVHFSG*ASRGCPSLFFMR*HLYN*LSFQRYL DNNEIKLFLNL

Frame 1

SGGDRGRCRRQSRPESARSRVHAERAGGSWRLG PCGAPAACPASASGPPSRSRRDGGRPGPRPRRV PPAALPLSAWARTAPRRSGSRARGPATTARGTD* FTLEL*VLMY*GAALIVP*RRVPK*ISKSRVSP WTSEQVSPKMLPDPQCLVRRENWCPQTRGPPAT VSAPGKVLALKVRLRRPLRGARIWTWGMSLRAVP PPPHHT*SGLSHCIPCWMTKMG*ACSGLS*SRR AVPTCWTSGLPALASGSWSPVTRTRRRG*SWRE PSTESTFLITMASCPGRPSQPPRAS*RAAS*SS* SILPCLTRPRPKSRPLWRKTPIPPSLSLIFIWN IRGQARRAPKSVVTRALGQGQGRAYLDTCRP*M KMRNGSVTRTWMRTMAETLLPPEDSLRSCSWRQL PRGSPPVDGTAKAESSGMDPGGSQSTPIMSMPA MPWPQPPVPTTASSRACPAMQTPCPSRTAAWMG SPHTGSVSSTAGRCRRACRSMGGCPYLTFPARTG CRRRSAWSLRSSRRSSSTAWRLCSARGRPRRSW RSG*SACAWRRKVRTAIHRQGPQGRVTSCLPPP LGTTSRPAVWTWAVPGSGMHTRRTLRASWTSTYS VC*GHLAASRLGLAIAPRTVGTWPRCQWHWGVP PRGTGSTYPSQGRSWTRPACTTTDTSTTTSTTA QPGPRSRWRPRPPAGPRAASPGAWNHTAMGQGPE ATQRVLALPPTPVMASPTVGRWAWRAKEMPRRL SRGRAPAPRCQVPRRMRRRTRKSCSGSLRGKRR SAGTAGPATGLRGRGSHSPMRTPDPCPLSTPGPA LSSGPPCSPPTSSSKTPPCHPTQLPTP*PSWRR RADVWRRKKREPAEHPPSRGQDRRGRWAAGVPS RVTASLWRTTSAGNPSPTAPW*GAALSPWASSRS C*PKRAATDTTSRK*ATSLTVGWCLRRFERTRP SCPSLRRRSSAKWRRWTDRLVGWPLCQARPLAG TGVTARQMTSYSGARWGTVLGVPPIPVVYPCLEA GRGSLQVVHKLLSCPQGGSLDHSS*QYLEGPAQ VRQPRSLLPASGDPPPSPGTSLGHVCWDLLSLW DLPTYPGLGGAQARMQRPAGPLSIVRATECLQHS LSLACHCVNRRRSTAPASSRRLCSPGSSFLRAR VNMYISQARPAGAARVCFSCDDTCTINYLFKGT WIIMK*NCF*TC

Frame 2

REAIVAAAAARAGRSRPGAASTRSGRVGAGGWA PAAPPRPAPRPPPGRRAAAAEMGAAPGRAPAGS RPPRCR*AHGPGPRRAAPGAGPGVPPPPRAGQI DSLWSCKY*CIRVQRSLFLDAESQNEYPRAGFPL GPRSKFHRRCSPTPSAW*GGRTGVHRPEARQLQ FLLRERCWH*R*DFDGHSEALGSGPGV*A*GQC LPHPTILEVG*VTAFPAG*PRWDKPVQDFPEAGG LCRLAGLLVCLHWLQEAGAL*LERGEEAEAGES HLPKVHS**QWHRVPADQASHQELHKGLHHEAA DRSCHV*PGPDRNPGHYGGKHLSLLP*V*YLFGI YEDRLGEPQSL**PELWVRDREGHIWIPADLK* R*GMEV*PGHG*GRWQRRCSPRKTPSEAAPGDS CPEGLLQ*TVQRRQRVQVWILAGASQPLLCQCRL CPGPSHQCQRQRAAEPVQRCRHPVPHGQQRGWD PPIQDP*AAPQGDAGERAGQWAGAPTSHSPHVP GAEGGPRGASEVRGGAHPPPGGCAAHAGGRGEAG GAAEARAHGGGR*GRRSIVRAPRAVSQAASRPR LAPLPAPLCGHGLCRAPGCTRGEP*EHPGRART ACAEDTWPPVAWAWPSLPGQWARGQDASGTGGCR LGAREARTQVRGEAGRGRPAPPPTRPPPRPPQH SPAQGAGGGRGHPQGPEQLRLGPGTTQPWGKVP RLLRECWRCPQRQ*WPRPQWEGGRGVQKKCQEG* VGEERQHRGARCLGGCGEEPENHAVDH*GGKGD QQAPQDRPRVFGDEEATAP*ELQTLVP*APLGR PSAPDLRAALPPLHPRPHHATPPSSQPPNPAGGG APTSGGGRKESQPSTLQAEDKIAEEGGRRECPA V*QHRCGVLLLRGTHPLPHPGEGPRCHPGPVQG AADQKGQLQILLQESERRV*LWGGV*GGSRGRGR PARL*GEDHRQSGEGGLIGWWAGRCARRGPWRA RVSRPGR*PRTQEPDGEQCWVYHPSLWSTRV*R QVGGPSKWSTSFCPAPKEAAWTTPHSNTWRAQPK *GSRGPCCQLQVTPPHPPAPPLGTCAGIYFPSG ICPRTQVWVGPRPGCRGLQGLCQLYAPPSAFNT ACLLPATV*IGDGALHLPPAAGCAVLGPPF*GPV *ICTFLRLGQQGLPESVFHAMTLVQLIIFSKVL G***NKTVFEP

Sequence AXIN1.aAug05

CTCGGGAGGCGATCGTGGCCGCTGCCGCCGCCAGAGCCGGCCGGAGTCGGCCCGGAGCCGCGTCCACGCGGAGCGGGCGGGTGGGAGCTGGCGGCTGGGC CCCTGCGGCGCCCCCGCGGCCTGCCCCGCGTCCGCCTCCGGGCCGCCGAGCCGCAGCCGCCGAGATGGGGGCCGCCCCGGGCCGCGCCCCCGCCGGGTCC CGCCCGCCGCGCTGCCGCTGAGCGCATGGGCCCGGACCGCGCCGCGCCGCTCCGGGAGCCGGGCCCGGGGTCCCGCCACCACCGCGCGCGGGACAGATTG ATTCACTTTGGAGCTGTAAGTACTGATGTATTAGGGTGCAGCGCTCATTGTTCCTTGACGCAGAGTCCCAAAATGAATATCCAAGAGCAGGGTTTCCCCT TGGACCTCGGAGCAAGTTTCACCGAAGATGCTCCCCGACCCCCAGTGCCTGGTGAGGAGGGAGAACTGGTGTCCACAGACCCGAGGCCCGCCAGCTACAG TTTCTGCTCCGGGAAAGGTGTTGGCATTAAAGGTGAGACTTCGACGGCCACTCCGAGGCGCTCGGATCTGGACCTGGGGTATGAGCCTGAGGGCAGTGCC TCCCCCACCCCACCATACTTGAAGTGGGCTGAGTCACTGCATTCCCTGCTGGATGACCAAGATGGGATAAGCCTGTTCAGGACTTTCCTGAAGCAGGAGG GCTGTGCCGACTTGCTGGACTTCTGGTTTGCCTGCACTGGCTTCAGGAAGCTGGAGCCCTGTGACTCGAACGAGGAGAAGAGGCTGAAGCTGGCGAGAGC CATCTACCGAAAGTACATTCTTGATAACAATGGCATCGTGTCCCGGCAGACCAAGCCAGCCACCAAGAGCTTCATAAAGGGCTGCATCATGAAGCAGCTG ATCGATCCTGCCATGTTTGACCAGGCCCAGACCGAAATCCAGGCCACTATGGAGGAAAACACCTATCCCTCCTTCCTTAAGTCTGATATTTATTTGGAAT ATACGAGGACAGGCTCGGAGAGCCCCAAAGTCTGTAGTGACCAGAGCTCTGGGTCAGGGACAGGGAAGGGCATATCTGGATACCTGCCGACCTTAAATGA AGATGAGGAATGGAAGTGTGACCAGGACATGGATGAGGACGATGGCAGAGACGCTGCTCCCCCCGGAAGACTCCCTCAGAAGCTGCTCCTGGAGACAGCT GCCCCGAGGGTCTCCTCCAGTAGACGGTACAGCGAAGGCAGAGAGTTCAGGTATGGATCCTGGCGGGAGCCAGTCAACCCCTATTATGTCAATGCCGGCT ATGCCCTGGCCCCAGCCACCAGTGCCAACGACAGCGAGCAGCAGAGCCTGTCCAGCGATGCAGACACCCTGTCCCTCACGGACAGCAGCGTGGATGGGAT CCCCCCATACAGGATCCGTAAGCAGCACCGCAGGGAGATGCAGGAGAGCGTGCAGGTCAATGGGCGGGTGCCCCTACCTCACATTCCCCGCACGTACCGG GTGCCGAAGGAGGTCCGCGTGGAGCCTCAGAAGTTCGCGGAGGAGCTCATCCACCGCCTGGAGGCTGTGCAGCGCACGCGGGAGGCCGAGGAGAAGCTGG AGGAGCGGCTGAAGCGCGTGCGCATGGAGGAGGAAGGTGAGGACGGCGATCCATCGTCAGGGCCCCCAGGGCCGTGTCACAAGCTGCCTCCCGCCCCCGC TTGGCACCACTTCCCGCCCCGCTGTGTGGACATGGGCTGTGCCGGGCTCCGGGATGCACACGAGGAGAACCCTGAGAGCATCCTGGACGAGCACGTACAG CGTGTGCTGAGGACACCTGGCCGCCAGTCGCCTGGGCCTGGCCATCGCTCCCCGGACAGTGGGCACGTGGCCAAGATGCCAGTGGCACTGGGGGGTGCCG CCTCGGGGCACGGGAAGCACGTACCCAAGTCAGGGGCGAAGCTGGACGCGGCCGGCCTGCACCACCACCGACACGTCCACCACCACGTCCACCACAGCAC AGCCCGGCCCAAGGAGCAGGTGGAGGCCGAGGCCACCCGCAGGGCCCAGAGCAGCTTCGCCTGGGGCCTGGAACCACACAGCCATGGGGCAAGGTCCCGA GGCTACTCAGAGAGTGTTGGCGCTGCCCCCAACGCCAGTGATGGCCTCGCCCACAGTGGGAAGGTGGGCGTGGCGTGCAAAAGAAATGCCAAGAAGGCTG AGTCGGGGAAGAGCGCCAGCACCGAGGTGCCAGGTGCCTCGGAGGATGCGGAGAAGAACCAGAAAATCATGCAGTGGATCATTGAGGGGGAAAAGGAGAT CAGCAGGCACCGCAGGACCGGCCACGGGTCTTCGGGGACGAGGAAGCCACAGCCCCATGAGAACTCCAGACCCTTGTCCCTTGAGCACCCCTGGGCCGGC CCTCAGCTCCGGACCTCCGTGCAGCCCTCCCACCTCTTCATCCAAGACCCCACCATGCCACCCCACCCAGCTCCCAACCCCCTAACCCAGCTGGAGGAGG CGCGCCGACGTCTGGAGGAGGAAGAAAAGAGAGCCAGCCGAGCACCCTCCAAGCAGAGGTATGTGCAGGAGGTTATGCGGCGGGGACGCGCCTGCGTCAG GCCAGCGTGCGCGCCGGTGCTGCACGTGGTACCAGCCGTGTCGGACATGGAGCTCTCCGAGACAGAGACAAGATCGCAGAGGAAGGTGGGCGGCGGGAGT GCCCAGCCGTGTGACAGCATCGTTGTGGCGTACTACTTCTGCGGGGAACCCATCCCCTACCGCACCCTGGTGAGGGGCCGCGCTGTCACCCTGGGCCAGT TCAAGGAGCTGCTGACCAAAAAGGGCAGCTACAGATACTACTTCAAGAAAGTGAGCGACGAGTTTGACTGTGGGGTGGTGTTTGAGGAGGTTCGAGAGGA CGAGGCCGTCCTGCCCGTCTTTGAGGAGAAGATCATCGGCAAAGTGGAGAAGGTGGACTGATAGGCTGGTGGGCTGGCCGCTGTGCCAGGCGAGGCCCTT GGCGGGCACGGGTGTCACGGCCAGGCAGATGACCTCGTACTCAGGAGCCCGATGGGGAACAGTGTTGGGTGTACCACCCATCCCTGTGGTCTACCCGTGT CTAGAGGCAGGTAGGGGGTCCCTCCAAGTGGTCCACAAGCTTCTGTCCTGCCCCCAAGGAGGCAGCCTGGACCACTCCTCATAGCAATACTTGGAGGGCC CAGCCCAAGTGAGGCAGCCGAGGTCCCTGCTGCCAGCTTCAGGTGACCCCCCCCCATCCCCCGGCACCTCCCTTGGGCACGTGTGCTGGGATCTACTTTC CCTCTGGGATTTGCCCACGTACCCAGGTCTGGGTGGGGCCCAGGCCCGGATGCAGAGGCCTGCAGGGCCTCTGTCAATTGTACGCGCCACCGAGTGCCTT CAACACAGCTTGTCTCTTGCCTGCCACTGTGTGAATCGGCGACGGAGCACTGCACCTGCCTCCAGCCGCCGGCTGTGCAGTCCTGGGTCCTCCTTTCTGA GGGCCCGTGTAAATATGTACATTTCTCAGGCTAGGCCAGCAGGGGCTGCCCGAGTCTGTTTTTCATGCGATGACACTTGTACAATTAATTATCTTTTCAA AGGTACTTGGATAATAATGAAATAAAACTGTTTTTGAACCTGC

AXIN1-3 (forward primer)
AXIN1-4 (reverse primer)
Single exon skipping

Frame 0

LGRRSWPLPPPEPAGVGPEPRPRGAGGWELAAG PLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGP ARRAAAERMGPDRAAPLREPGPGSRHHRARDRL IHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFP LDLGASFTEDAPRPPVPGEEGELVSTDPRPASYS FCSGKGVGIKGETSTATPRRSDLDLGYEPEGSA SPTPPYLKWAESLHSLLDDQDGISLFRTFLKQE GCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA IYRKYILDNNGIVSRQTKPATKSFIKGCIMKQL IDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE YTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETA APRVSSSRRYSEGREFRYGSWREPVNPYYVNAG YALAPATSANDSEQQSLSSDADTLSLTDSSVDGI PPYRIRKQHRREMQESVQVNGRVPLPHIPRTYR VPKEVRVEPQKFAEELIHRLEAVQRTREAEEKL EERLKRVRMEEEGEDGDPSSGPPGPCHKLPPAPA WHHFPPRCVDMGCAGLRDAHEENPESILDEHVQ RVLRTPGRQSPGPGHRSPDSGHVAKMPVALGGA ASGHGKHVPKSGAKLDAAGLHHHRHVHHHVHHST ARPKEQVEAEATRRAQSSFAWGLEPHSHGARSR GYSESVGAAPNASDGLAHSGKVGVACKRNAKKA ESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEI SRHRRTGHGSSGTRKPQPHENSRPLSLEHPWAG PQLRTSVQPSHLFIQDPTMPPHPAPNPLTQLEE ARRRLEEEEKRASRAPSKQRYVQEVMRRGRACVR PACAPVLHVVPAVSDMELSETETRSQRKVGGGS AQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQ FKELLTKKGSYRYYFKKVSDEFDCGVVFEEVRED EAVLPVFEEKIIGKVEKVD**AGGLAAVPGEAL GGHGCHGQADDLVLRSPMGNSVGCTTHPCGLPV SRGR*GVPPSGPQASVLPPRRQPGPLLIAILGGP SPSEAAEVPAASFR*PPPIPRHLPWARVLGSTF PLGFAHVPRSGWGPGPDAEACRASVNCTRHRVP STQLVSCLPLCESATEHCTCLQPPAVQSWVLLSE GPCKYVHFSG*ASRGCPSLFFMR*HLYN*LSFQ RYLDNNEIKLFLNL

Frame 1

SGGDRGRCRRQSRPESARSRVHAERAGGSWRLG PCGAPAACPASASGPPSRSRRDGGRPGPRPRRV PPAALPLSAWARTAPRRSGSRARGPATTARGTD* FTLEL*VLMY*GAALIVP*RRVPK*ISKSRVSP WTSEQVSPKMLPDPQCLVRRENWCPQTRGPPAT VSAPGKVLALKVRLRRPLRGARIWTWGMSLRAVP PPPHHT*SGLSHCIPCWMTKMG*ACSGLS*SRR AVPTCWTSGLPALASGSWSPVTRTRRRG*SWRE PSTESTFLITMASCPGRPSQPPRAS*RAAS*SS* SILPCLTRPRPKSRPLWRKTPIPPSLSLIFIWN IRGQARRAPKSVVTRALGQGQGRAYLDTCRP*M KMRNGSVTRTWMRTMAETLLPPEDSLRSCSWRQL PRGSPPVDGTAKAESSGMDPGGSQSTPIMSMPA MPWPQPPVPTTASSRACPAMQTPCPSRTAAWMG SPHTGSVSSTAGRCRRACRSMGGCPYLTFPARTG CRRRSAWSLRSSRRSSSTAWRLCSARGRPRRSW RSG*SACAWRRKVRTAIHRQGPQGRVTSCLPPP LGTTSRPAVWTWAVPGSGMHTRRTLRASWTSTYS VC*GHLAASRLGLAIAPRTVGTWPRCQWHWGVP PRGTGSTYPSQGRSWTRPACTTTDTSTTTSTTA QPGPRSRWRPRPPAGPRAASPGAWNHTAMGQGPE ATQRVLALPPTPVMASPTVGRWAWRAKEMPRRL SRGRAPAPRCQVPRRMRRRTRKSCSGSLRGKRR SAGTAGPATGLRGRGSHSPMRTPDPCPLSTPGPA LSSGPPCSPPTSSSKTPPCHPTQLPTP*PSWRR RADVWRRKKREPAEHPPSRGMCRRLCGGDAPAS GQRARRCCTWYQPCRTWSSPRQRQDRRGRWAAGV PSRVTASLWRTTSAGNPSPTAPW*GAALSPWAS SRSC*PKRAATDTTSRK*ATSLTVGWCLRRFER TRPSCPSLRRRSSAKWRRWTDRLVGWPLCQARPL AGTGVTARQMTSYSGARWGTVLGVPPIPVVYPC LEAGRGSLQVVHKLLSCPQGGSLDHSS*QYLEG PAQVRQPRSLLPASGDPPPSPGTSLGHVCWDLLS LWDLPTYPGLGGAQARMQRPAGPLSIVRATECL QHSLSLACHCVNRRRSTAPASSRRLCSPGSSFL RARVNMYISQARPAGAARVCFSCDDTCTINYLFK GTWIIMK*NCF*TC

Frame 2

REAIVAAAAARAGRSRPGAASTRSGRVGAGGWA PAAPPRPAPRPPPGRRAAAAEMGAAPGRAPAGS RPPRCR*AHGPGPRRAAPGAGPGVPPPPRAGQI DSLWSCKY*CIRVQRSLFLDAESQNEYPRAGFPL GPRSKFHRRCSPTPSAW*GGRTGVHRPEARQLQ FLLRERCWH*R*DFDGHSEALGSGPGV*A*GQC LPHPTILEVG*VTAFPAG*PRWDKPVQDFPEAGG LCRLAGLLVCLHWLQEAGAL*LERGEEAEAGES HLPKVHS**QWHRVPADQASHQELHKGLHHEAA DRSCHV*PGPDRNPGHYGGKHLSLLP*V*YLFGI YEDRLGEPQSL**PELWVRDREGHIWIPADLK* R*GMEV*PGHG*GRWQRRCSPRKTPSEAAPGDS CPEGLLQ*TVQRRQRVQVWILAGASQPLLCQCRL CPGPSHQCQRQRAAEPVQRCRHPVPHGQQRGWD PPIQDP*AAPQGDAGERAGQWAGAPTSHSPHVP GAEGGPRGASEVRGGAHPPPGGCAAHAGGRGEAG GAAEARAHGGGR*GRRSIVRAPRAVSQAASRPR LAPLPAPLCGHGLCRAPGCTRGEP*EHPGRART ACAEDTWPPVAWAWPSLPGQWARGQDASGTGGCR LGAREARTQVRGEAGRGRPAPPPTRPPPRPPQH SPAQGAGGGRGHPQGPEQLRLGPGTTQPWGKVP RLLRECWRCPQRQ*WPRPQWEGGRGVQKKCQEG* VGEERQHRGARCLGGCGEEPENHAVDH*GGKGD QQAPQDRPRVFGDEEATAP*ELQTLVP*APLGR PSAPDLRAALPPLHPRPHHATPPSSQPPNPAGGG APTSGGGRKESQPSTLQAEVCAGGYAAGTRLRQ ASVRAGAARGTSRVGHGALRDRDKIAEEGGRRE CPAV*QHRCGVLLLRGTHPLPHPGEGPRCHPGPV QGAADQKGQLQILLQESERRV*LWGGV*GGSRG RGRPARL*GEDHRQSGEGGLIGWWAGRCARRGP WRARVSRPGR*PRTQEPDGEQCWVYHPSLWSTRV *RQVGGPSKWSTSFCPAPKEAAWTTPHSNTWRA QPK*GSRGPCCQLQVTPPHPPAPPLGTCAGIYF PSGICPRTQVWVGPRPGCRGLQGLCQLYAPPSAF NTACLLPATV*IGDGALHLPPAAGCAVLGPPF* GPV*ICTFLRLGQQGLPESVFHAMTLVQLIIFS KVLG***NKTVFEP