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Sequences

Sequence BRCA1.mAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC
GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT
GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA
GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA
GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA
TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC
TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC
TCT
AACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGATCTGATTCTTCTGAAGATA
CCGTTAATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAAA
GG
GTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGGGAT
ACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTTCCA
TCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCCTAT
AAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTCATCCCCT
TCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTG
TTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGA
ATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACCTCT
GCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAAGTG
TGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCTCGT
GTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAA
CGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGC
ATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGA
AATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTC
ACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCACCTG
TGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGACT
GCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTAC
TGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAA
TCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCA
GCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTA
AAACCCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGT
TCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAA
TCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAC
AGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGA
GCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATTTCTAAA
AGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTA
GTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACA
GATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCT
GAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAG
TGAAGACTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA
  • BRCA1-F2 (forward primer)
  • BRCA1-R2 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL
RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL
LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR
VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE
RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH
LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF
YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT
L
*PWNCENSEDKAADTTSKDVCLH*IGI*FF*RY
R**GNLLQCGRSRIVTNHPSRNQG*NQFGFCKK
G
*SSIWV*E*NKRL*RLLRAILSE*HFNHSAEG
YHAT*PDKAPAGNG*TRSCVRTAWEPAF*QLPFH
HK*LFCP*GPAKSRTKHIRKSSINFTEK**IPY
KPESRRPFC*QV*GVCR*FYQ*K*RTRSGKVIP
F*MPIIR**VVHAQLLWESSE*KLPISRGAH*GC
*CGGATAGRVWATRFDGNILLAKARSRGNPLPG
IWNQPLL**P*I*SF*RQSPRVSSCWQHTIFNL
CIESSPIESCRICPESSCCSYY*YCWV*CNGRKC
EQGEARIDSFNRKGQQKNVHGGVWPDPRRIYAR
VQVCQKTPHHFN*SNY*RDYSCCYENRC*VCV*
TDTEIFSRNCGRKMGS*LFLGDPVY*RKKNAE*A
*F*SQRRCGQWKKPPRSKASKRIPGQKDLQGAR
NLLLWALHQHAHRSTGMDGTAVWCFCGEGAFII
HPWHRCPPNCGCAARCLDRGQWLPCNWADV*GTC
GDPRVGVGQCSTLPVPGAGHLPDTPDPPQPLLT
AASHRYRATGPQE*AYKVAFPGPGSSSHSSVLL
LSWLLNILCTSA*KGLLAMQGSLKDFLLEVSLGN
LP*AQNYGNFSPEKILKPFKRHQLSKMLIHYLS
ALFFLFRLLLA*GWKHRVAWPQENSWFP*VYFS
KTLCSQRQRVRPFNGRRVLGIDYVT*SQNSPWAV
LKCWSGTLGRKF*GRY*K*KGNLKPGHGGSRL*
SQHFGRPRWADHWRSGVRNQPGQHGETPSLLKI
QKLAGHGGGHL*SQLLRWLRQENHFSPGGGGCSE
PRSYHGTPAWVTVRLWLKKKKKKRKMKLEEISK
SLRYIC*ISKECVLKQQKIFKNRFPKTVF*FLI
SNK*NVYCCSSGI*SIPLKI*DLWHEYFISIK*Q
IPPGRKLLLSLR*FFSFAPCC*NHTAS*IILLA
EGRKSVFHKPIIQDCL*LLEGLGLP*PPQCARA
VKT*LYKIRFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC
DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL
CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE
CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK
GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI
ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS
IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL
S
NLGTVRTLRTKQRIQPQKTSVYIELGSDSSED
TVNKATYCSVGDQELLQITPQGTRDEISLDSAKK
GEAASGCESETSVSEDCSGLSSQSDILTTQQRD
TMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPS
IISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPI
SQNPEGLSADKFEVSADSSTSKNKEPGVERSSP
SKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKV
VDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLE
SGISLFSDDPESDPSEDRAPESARVGNIPSSTS
ALKVPQLKVAESAQSPAAAHTTDTAGYNAMEES
VSREKPELTASTERVNKRMSMVVSGLTPEEFMLV
YKFARKHHITLTNLITEETTHVVMKTDAEFVCE
RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNE
HDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLE
ICCYGPFTNMPTDQLEWMVQLCGASVVKELSSF
TLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAP
VVTREWVLDSVALYQCQELDTYLIPQIPHSHY*L
QPATGTEPQDPKNELTKWPFQALGAPLTLQSFY
CPGY*IFYVHQPEKDFWLCKGPLKIFCLKSPLE
ICHEHKIMVIFHLRRF*NHLNATN*ARC*FIIYQ
PYSFYSGCCWLRAGSTEWLGLKRIAGFPKFTSL
KPCVHKGRESDPSMEGECLGSIM*LKVRIVLGQ
FSNVGVEHWGGNSEAGIRNEKET*NLGMVAHACN
PSTLGGQGGQITGGQEFETSLANMVKPHLY*KY
RN*PVMVVDTCNPSYSGG*GRRITSAREVEVAV
SQDHTTALQPG*Q*DCGSKKKKKKGK*N*KRFLK
V*DIFARFLKNVF*NSRRFSRTGFQRQSSNSSL
VISKMFIVVALVYNPFLLKYKTSGMNISYL*ND
RSHQEGSCCFL*GDFFPLLPVAETIQLHK*FCLL
KEEKVFFINPLSRTVYSCWKD*VFPSPPSVQGQ
*RLDCTKYVL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA
TARRELAETSWTGDRLWGFSDNWAPALRRPSPS
ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS*
SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK
GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS
FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF
LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS
L
TLEL*EL*GQSSGYNLKRRLSTLNWDLILLKI
PLIRQLIAVWEIKNCYKSPLKEPGMKSVWILQK
R
VKQHLGVRVKQASLKTAQGYPLRVTF*PLSRGI
PCNIT**SSSRKWLN*KLC*NSMGASLLTATLP
S*VTLLPLRTCEIQNKAHQKKQY*LHRKVVNTL
*ARIQKAFLLTSLRCLQIVLPVKIKNQEWKGHPL
LNAHH*MIGGTCTVALGVFRIETTHLKRSSLRL
LMWRSNSWKSLGHTI*RKHLTCQGKI*REPLTW
NLESASSLMTLNLILLKTEPQSQLVLATYHLQPL
H*KFPN*KLQNLPRVQLLLILLILLGIMQWKKV
*AGRSQN*QLQQKGSTKECPWWCLA*PQKNLCS
CTSLPENTTSL*LI*LLKRLLMLL*KQMLSLCVN
GH*NIF*ELREENG*LAISG*PSLLKKEKC*MS
MILKSEEMWSMEETTKVQSEQENPRTERSSGG*
KSVAMGPSPTCPQINWNGWYSCVVLLW*RSFHHS
PLAQVSTQLWLCSQMPGQRTMASMQLGRCVRHL
W*PESGCWTV*HSTSARSWTPT*YPRSPTATTD
CSQPQVQSHRTPRMSLQSGLSRPWELLSLFSPST
VLATKYFMYISLKRTSGYARVP*RFSA*SLPWK
SAMSTKLW*FFT*EDFKTI*TPPIEQDADSLFI
SPILSIQAVVGLGLEAQSGLASRE*LVSLSLLL*
NPVFTKAESQTLQWKESAWDRLCDLKSE*SLGS
SQMLEWNIGEEILRQVLEMKRKLETWAWWLTPV
IPALWEAKVGRSLEVRSSKPAWPTW*NPISTKNT
EISRSWWWTPVIPATQVAKAGESLQPGRWRLQ*
AKIIPRHSSLGDSETVAQKKKKKKENETRRDF*
KSEIYLLDF*RMCSKTAEDFQEPVSKDSLLIPH*
**VKCLLL*LWYIIHSS*NIRPLA*IFHIYKMT
DPTRKEAVAFFEVIFFLCSLLLKPYSFINNFAC
*RKKKCFS*THYPGLFIAVGRTRSSLAPPVCKGS
EDLIVQNTFCKCCAVNTANKLGSKHF

Sequence BRCA1.dAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC
GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT
GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA
GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA
GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA
TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC
TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC
TCT
AACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGCTGCTTGTGAATTTTCTGAGA
CGGATGTAACAAATACTGAACATCATCAACCCAGTAATAATGATTTGAACACCACTGAGAAGCGTGCAGCTGAGAGGCATCCAGAAAAGTATCAGGGTAG
TTCTGTTTCAAACTTGCATGTGGAGCCATGTGGCACAAATACTCATGCCAGCTCATTACAGCATGAGAACAGCAGTTTATTACTCACTAAAGACAGAATG
AATGTAGAAAAGGCTGAATTCTGTAATAAAAGCAAACAGCCTGGCTTAGCAAGGAGCCAACATAACAGATGGGCTGGAAGTAAGGAAACATGTAATGATA
GGCGGACTCCCAGCACAGAAAAAAAGGTAGATCTGAATGCTGATCCCCTGTGTGAGAGAAAAGAATGGAATAAGCAGAAACTGCCATGCTCAGAGAATCC
TAGAGATACTGAAGATGTTCCTTGGATAACACTAAATAGCAGCATTCAGAAAGTTAATGAGTGGTTTTCCAGAAGTGATGAACTGTTAGGTTCTGATGAC
TCACATGATGGGGAGTCTGAATCAAATGCCAAAGTAGCTGATGTATTGGACGTTCTAAATGAGGTAGATGAATATTCTGGTTCTTCAGAGAAAATAGACT
TACTGGCCAGTGATCCTCATGAGGCTTTAATATGTAAAAGTGAAAGAGTTCACTCCAAATCAGTAGAGAGTAATATTGAAGACAAAATATTTGGGAAAAC
CTATCGGAAGAAGGCAAGCCTCCCCAACTTAAGCCATGTAACTGAAAATCTAATTATAGGAGCATTTGTTACTGAGCCACAGATAATACAAGAGCGTCCC
CTCACAAATAAATTAAAGCGTAAAAGGAGACCTACATCAGGCCTTCATCCTGAGGATTTTATCAAGAAAGCAGATTTGGCAGTTCAAAAGACTCCTGAAA
TGATAAATCAGGGAACTAACCAAACGGAGCAGAATGGTCAAGTGATGAATATTACTAATAGTGGTCATGAGAATAAAACAAAAGGTGATTCTATTCAGAA
TGAGAAAAATCCTAACCCAATAGAATCACTCGAAAAAGAATCTGCTTTCAAAACGAAAGCTGAACCTATAAGCAGCAGTATAAGCAATATGGAACTCGAA
TTAAATATCCACAATTCAAAAGCACCTAAAAAGAATAGGCTGAGGAGGAAGTCTTCTACCAGGCATATTCATGCGCTTGAACTAGTAGTCAGTAGAAATC
TAAGCCCACCTAATTGTACTGAATTGCAAATTGATAGTTGTTCTAGCAGTGAAGAGATAAAGAAAAAAAAGTACAACCAAATGCCAGTCAGGCACAGCAG
AAACCTACAACTCATGGAAGGTAAAGAACCTGCAACTGGAGCCAAGAAGAGTAACAAGCCAAATGAACAGACAAGTAAAAGACATGACAGCGATACTTTC
CCAGAGCTGAAGTTAACAAATGCACCTGGTTCTTTTACTAAGTGTTCAAATACCAGTGAACTTAAAGAATTTGTCAATCCTAGCCTTCCAAGAGAAGAAA
AAGAAGAGAAACTAGAAACAGTTAAAGTGTCTAATAATGCTGAAGACCCCAAAGATCTCATGTTAAGTGGAGAAAGGGTTTTGCAAACTGAAAGATCTGT
AGAGAGTAGCAGTATTTCATTGGTACCTGGTACTGATTATGGCACTCAGGAAAGTATCTCGTTACTGGAAGTTAGCACTCTAGGGAAGGCAAAAACAGAA
CCAAATAAATGTGTGAGTCAGTGTGCAGCATTTGAAAACCCCAAGGGACTAATTCATGGTTGTTCCAAAGATAATAGAAATGACACAGAAGGCTTTAAGT
ATCCATTGGGACATGAAGTTAACCACAGTCGGGAAACAAGCATAGAAATGGAAGAAAGTGAACTTGATGCTCAGTATTTGCAGAATACATTCAAGGTTTC
AAAGCGCCAGTCATTTGCTCCGTTTTCAAATCCAGGAAATGCAGAAGAGGAATGTGCAACATTCTCTGCCCACTCTGGGTCCTTAAAGAAACAAAGTCCA
AAAGTCACTTTTGAATGTGAACAAAAGGAAGAAAATCAAGGAAAGAATGAGTCTAATATCAAGCCTGTACAGACAGTTAATATCACTGCAGGCTTTCCTG
TGGTTGGTCAGAAAGATAAGCCAGTTGATAATGCCAAATGTAGTATCAAAGGAGGCTCTAGGTTTTGTCTATCATCTCAGTTCAGAGGCAACGAAACTGG
ACTCATTACTCCAAATAAACATGGACTTTTACAAAACCCATATCGTATACCACCACTTTTTCCCATCAAGTCATTTGTTAAAACTAAATGTAAGAAAAAT
CTGCTAGAGGAAAACTTTGAGGAACATTCAATGTCACCTGAAAGAGAAATGGGAAATGAGAACATTCCAAGTACAGTGAGCACAATTAGCCGTAATAACA
TTAGAGAAAATGTTTTTAAAGAAGCCAGCTCAAGCAATATTAATGAAGTAGGTTCCAGTACTAATGAAGTGGGCTCCAGTATTAATGAAATAGGTTCCAG
TGATGAAAACATTCAAGCAGAACTAGGTAGAAACAGAGGGCCAAAATTGAATGCTATGCTTAGATTAGGGGTTTTGCAACCTGAGGTCTATAAACAAAGT
CTTCCTGGAAGTAATTGTAAGCATCCTGAAATAAAAAAGCAAGAATATGAAGAAGTAGTTCAGACTGTTAATACAGATTTCTCTCCATATCTGATTTCAG
ATAACTTAGAACAGCCTATGGGAAGTAGTCATGCATCTCAGGTTTGTTCTGAGACACCTGATGACCTGTTAGATGATGGTGAAATAAAGGAAGATACTAG
TTTTGCTGAAAATGACATTAAGGAAAGTTCTGCTGTTTTTAGCAAAAGCGTCCAGAAAGGAGAGCTTAGCAGGAGTCCTAGCCCTTTCACCCATACACAT
TTGGCTCAGGGTTACCGAAGAGGGGCCAAGAAATTAGAGTCCTCAGAAGAGAACTTATCTAGTGAGGATGAAGAGCTTCCCTGCTTCCAACACTTGTTAT
TTGGTAAAGTAAACAATATACCTTCTCAGTCTACTAGGCATAGCACCGTTGCTACCGAGTGTCTGTCTAAGAACACAGAGGAGAATTTATTATCATTGAA
GAATAGCTTAAATGACTGCAGTAACCAGGTAATATTGGCAAAGGCATCTCAGGAACATCACCTTAGTGAGGAAACAAAATGTTCTGCTAGCTTGTTTTCT
TCACAGTGCAGTGAATTGGAAGACTTGACTGCAAATACAAACACCCAGGATCCTTTCTTGATTGGTTCTTCCAAACAAATGAGGCATCAGTCTGAAAGCC
AGGGAGTTGGTCTGAGTGACAAGGAATTGGTTTCAGATGATGAAGAAAGAGGAACGGGCTTGGAAGAAAATAATCAAGAAGAGCAAAGCATGGATTCAAA
CTTAG
GTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGG
GATACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTT
CCATCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCC
TATAAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTCATCC
CCTTCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGG
TTGTTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCT
GGAATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACC
TCTGCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAA
GTGTGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCT
CGTGTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGT
GAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATG
AGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCT
AGAAATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCA
TTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCAC
CTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTG
ACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTC
TACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGG
AAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTA
TCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCT
CTAAAACCCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGC
AGTTCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTG
TAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAA
TACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAG
TGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATTTCT
AAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTTCTAATTCCTCA
TTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATG
ACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTT
GCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGG
CAGTGAAGACTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA
  • BRCA1-F2 (forward primer)
  • BRCA1-R2 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL
RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL
LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR
VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE
RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH
LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF
YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT
L
*PWNCENSEDKAADTTSKDVCLH*IGCL*IF*D
GCNKY*TSSTQ***FEHH*EACS*EASRKVSG*
FCFKLACGAMWHKYSCQLITA*EQQFITH*RQN
ECRKG*IL**KQTAWLSKEPT*QMGWK*GNM***
ADSQHRKKGRSEC*SPV*EKRME*AETAMLRES
*RY*RCSLDNTK*QHSES**VVFQK**TVRF**
LT*WGV*IKCQSS*CIGRSK*GR*IFWFFRENRL
TGQ*SS*GFNM*K*KSSLQISRE*Y*RQNIWEN
LSEEGKPPQLKPCN*KSNYRSICY*ATDNTRAS
PHK*IKA*KETYIRPSS*GFYQESRFGSSKDS*N
DKSGN*PNGAEWSSDEYY**WS*E*NKR*FYSE
*EKS*PNRITRKRICFQNES*TYKQQYKQYGTR
IKYPQFKST*KE*AEEEVFYQAYSCA*TSSQ*KS
KPT*LY*IAN**LF*Q*RDKEKKVQPNASQAQQ
KPTTHGR*RTCNWSQEE*QAK*TDK*KT*QRYF
PRAEVNKCTWFFY*VFKYQ*T*RICQS*PSKRRK
RRETRNS*SV**C*RPQRSHVKWRKGFAN*KIC
RE*QYFIGTWY*LWHSGKYLVTGS*HSREGKNR
TK*MCESVCSI*KPQGTNSWLFQR**K*HRRL*V
SIGT*S*PQSGNKHRNGRK*T*CSVFAEYIQGF
KAPVICSVFKSRKCRRGMCNILCPLWVLKETKS
KSHF*M*TKGRKSRKE*V*YQACTDS*YHCRLSC
GWSER*AS**CQM*YQRRL*VLSIISVQRQRNW
THYSK*TWTFTKPISYTTTFSHQVIC*N*M*EK
SARGKL*GTFNVT*KRNGK*EHSKYSEHN*P**H
*RKCF*RSQLKQY**SRFQY**SGLQY**NRFQ
**KHSSRTR*KQRAKIECYA*IRGFAT*GL*TK
SSWK*L*AS*NKKARI*RSSSDC*YRFLSISDFR
*LRTAYGK*SCISGLF*DT**PVR*W*NKGRY*
FC*K*H*GKFCCF*QKRPERRA*QES*PFHPYT
FGSGLPKRGQEIRVLRRELI**G*RASLLPTLVI
W*SKQYTFSVY*A*HRCYRVSV*EHRGEFIIIE
E*LK*LQ*PGNIGKGISGTSP**GNKMFC*LVF
FTVQ*IGRLDCKYKHPGSFLDWFFQTNEASV*KP
GSWSE*QGIGFR**RKRNGLGRK*SRRAKHGFK
LR
*SSIWV*E*NKRL*RLLRAILSE*HFNHSAE
GYHAT*PDKAPAGNG*TRSCVRTAWEPAF*QLPF
HHK*LFCP*GPAKSRTKHIRKSSINFTEK**IP
YKPESRRPFC*QV*GVCR*FYQ*K*RTRSGKVI
PF*MPIIR**VVHAQLLWESSE*KLPISRGAH*G
C*CGGATAGRVWATRFDGNILLAKARSRGNPLP
GIWNQPLL**P*I*SF*RQSPRVSSCWQHTIFN
LCIESSPIESCRICPESSCCSYY*YCWV*CNGRK
CEQGEARIDSFNRKGQQKNVHGGVWPDPRRIYA
RVQVCQKTPHHFN*SNY*RDYSCCYENRC*VCV
*TDTEIFSRNCGRKMGS*LFLGDPVY*RKKNAE*
A*F*SQRRCGQWKKPPRSKASKRIPGQKDLQGA
RNLLLWALHQHAHRSTGMDGTAVWCFCGEGAFI
IHPWHRCPPNCGCAARCLDRGQWLPCNWADV*GT
CGDPRVGVGQCSTLPVPGAGHLPDTPDPPQPLL
TAASHRYRATGPQE*AYKVAFPGPGSSSHSSVL
LLSWLLNILCTSA*KGLLAMQGSLKDFLLEVSLG
NLP*AQNYGNFSPEKILKPFKRHQLSKMLIHYL
SALFFLFRLLLA*GWKHRVAWPQENSWFP*VYF
SKTLCSQRQRVRPFNGRRVLGIDYVT*SQNSPWA
VLKCWSGTLGRKF*GRY*K*KGNLKPGHGGSRL
*SQHFGRPRWADHWRSGVRNQPGQHGETPSLLK
IQKLAGHGGGHL*SQLLRWLRQENHFSPGGGGCS
EPRSYHGTPAWVTVRLWLKKKKKKRKMKLEEIS
KSLRYIC*ISKECVLKQQKIFKNRFPKTVF*FL
ISNK*NVYCCSSGI*SIPLKI*DLWHEYFISIK*
QIPPGRKLLLSLR*FFSFAPCC*NHTAS*IILL
AEGRKSVFHKPIIQDCL*LLEGLGLP*PPQCAR
AVKT*LYKIRFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC
DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL
CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE
CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK
GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI
ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS
IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL
S
NLGTVRTLRTKQRIQPQKTSVYIELAACEFSE
TDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGS
SVSNLHVEPCGTNTHASSLQHENSSLLLTKDRM
NVEKAEFCNKSKQPGLARSQHNRWAGSKETCND
RRTPSTEKKVDLNADPLCERKEWNKQKLPCSENP
RDTEDVPWITLNSSIQKVNEWFSRSDELLGSDD
SHDGESESNAKVADVLDVLNEVDEYSGSSEKID
LLASDPHEALICKSERVHSKSVESNIEDKIFGKT
YRKKASLPNLSHVTENLIIGAFVTEPQIIQERP
LTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPE
MINQGTNQTEQNGQVMNITNSGHENKTKGDSIQN
EKNPNPIESLEKESAFKTKAEPISSSISNMELE
LNIHNSKAPKKNRLRRKSSTRHIHALELVVSRN
LSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSR
NLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTF
PELKLTNAPGSFTKCSNTSELKEFVNPSLPREE
KEEKLETVKVSNNAEDPKDLMLSGERVLQTERSV
ESSSISLVPGTDYGTQESISLLEVSTLGKAKTE
PNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFK
YPLGHEVNHSRETSIEMEESELDAQYLQNTFKVS
KRQSFAPFSNPGNAEEECATFSAHSGSLKKQSP
KVTFECEQKEENQGKNESNIKPVQTVNITAGFP
VVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETG
LITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKN
LLEENFEEHSMSPEREMGNENIPSTVSTISRNN
IRENVFKEASSSNINEVGSSTNEVGSSINEIGSS
DENIQAELGRNRGPKLNAMLRLGVLQPEVYKQS
LPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLIS
DNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTS
FAENDIKESSAVFSKSVQKGELSRSPSPFTHTH
LAQGYRRGAKKLESSEENLSSEDEELPCFQHLL
FGKVNNIPSQSTRHSTVATECLSKNTEENLLSLK
NSLNDCSNQVILAKASQEHHLSEETKCSASLFS
SQCSELEDLTANTNTQDPFLIGSSKQMRHQSES
QGVGLSDKELVSDDEERGTGLEENNQEEQSMDSN
L
GEAASGCESETSVSEDCSGLSSQSDILTTQQR
DTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYP
SIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYP
ISQNPEGLSADKFEVSADSSTSKNKEPGVERSS
PSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIK
VVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYL
ESGISLFSDDPESDPSEDRAPESARVGNIPSST
SALKVPQLKVAESAQSPAAAHTTDTAGYNAMEE
SVSREKPELTASTERVNKRMSMVVSGLTPEEFML
VYKFARKHHITLTNLITEETTHVVMKTDAEFVC
ERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLN
EHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGL
EICCYGPFTNMPTDQLEWMVQLCGASVVKELSS
FTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEA
PVVTREWVLDSVALYQCQELDTYLIPQIPHSHY*
LQPATGTEPQDPKNELTKWPFQALGAPLTLQSF
YCPGY*IFYVHQPEKDFWLCKGPLKIFCLKSPL
EICHEHKIMVIFHLRRF*NHLNATN*ARC*FIIY
QPYSFYSGCCWLRAGSTEWLGLKRIAGFPKFTS
LKPCVHKGRESDPSMEGECLGSIM*LKVRIVLG
QFSNVGVEHWGGNSEAGIRNEKET*NLGMVAHAC
NPSTLGGQGGQITGGQEFETSLANMVKPHLY*K
YRN*PVMVVDTCNPSYSGG*GRRITSAREVEVA
VSQDHTTALQPG*Q*DCGSKKKKKKGK*N*KRFL
KV*DIFARFLKNVF*NSRRFSRTGFQRQSSNSS
LVISKMFIVVALVYNPFLLKYKTSGMNISYL*N
DRSHQEGSCCFL*GDFFPLLPVAETIQLHK*FCL
LKEEKVFFINPLSRTVYSCWKD*VFPSPPSVQG
Q*RLDCTKYVL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA
TARRELAETSWTGDRLWGFSDNWAPALRRPSPS
ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS*
SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK
GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS
FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF
LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS
L
TLEL*EL*GQSSGYNLKRRLSTLNWLLVNFLR
RM*QILNIINPVIMI*TPLRSVQLRGIQKSIRV
VLFQTCMWSHVAQILMPAHYSMRTAVYYSLKTE*
M*KRLNSVIKANSLA*QGANITDGLEVRKHVMI
GGLPAQKKR*I*MLIPCVREKNGISRNCHAQRI
LEILKMFLG*H*IAAFRKLMSGFPEVMNC*VLMT
HMMGSLNQMPK*LMYWTF*MR*MNILVLQRK*T
YWPVILMRL*YVKVKEFTPNQ*RVILKTKYLGK
PIGRRQASPT*AM*LKI*L*EHLLLSHR*YKSVP
SQIN*SVKGDLHQAFILRILSRKQIWQFKRLLK
**IRELTKRSRMVK**ILLIVVMRIKQKVILFR
MRKILTQ*NHSKKNLLSKRKLNL*AAV*AIWNSN
*ISTIQKHLKRIG*GGSLLPGIFMRLN**SVEI
*AHLIVLNCKLIVVLAVKR*RKKSTTKCQSGTA
ETYNSWKVKNLQLEPRRVTSQMNRQVKDMTAILS
QS*S*QMHLVLLLSVQIPVNLKNLSILAFQEKK
KKRN*KQLKCLIMLKTPKISC*VEKGFCKLKDL
*RVAVFHWYLVLIMALRKVSRYWKLAL*GRQKQN
QINV*VSVQHLKTPRD*FMVVPKIIEMTQKALS
IHWDMKLTTVGKQA*KWKKVNLMLSICRIHSRF
QSASHLLRFQIQEMQKRNVQHSLPTLGP*RNKVQ
KSLLNVNKRKKIKERMSLISSLYRQLISLQAFL
WLVRKISQLIMPNVVSKEALGFVYHLSSEATKL
DSLLQINMDFYKTHIVYHHFFPSSHLLKLNVRKI
C*RKTLRNIQCHLKEKWEMRTFQVQ*AQLAVIT
LEKMFLKKPAQAILMK*VPVLMKWAPVLMK*VP
VMKTFKQN*VETEGQN*MLCLD*GFCNLRSINKV
FLEVIVSILK*KSKNMKK*FRLLIQISLHI*FQ
IT*NSLWEVVMHLRFVLRHLMTC*MMVK*RKIL
VLLKMTLRKVLLFLAKASRKESLAGVLALSPIHI
WLRVTEEGPRN*SPQKRTYLVRMKSFPASNTCY
LVK*TIYLLSLLGIAPLLPSVCLRTQRRIYYH*
RIA*MTAVTR*YWQRHLRNITLVRKQNVLLACFL
HSAVNWKT*LQIQTPRILS*LVLPNK*GISLKA
RELV*VTRNWFQMMKKEERAWKKIIKKSKAWIQ
T*
VKQHLGVRVKQASLKTAQGYPLRVTF*PLSRG
IPCNIT**SSSRKWLN*KLC*NSMGASLLTATL
PS*VTLLPLRTCEIQNKAHQKKQY*LHRKVVNT
L*ARIQKAFLLTSLRCLQIVLPVKIKNQEWKGHP
LLNAHH*MIGGTCTVALGVFRIETTHLKRSSLR
LLMWRSNSWKSLGHTI*RKHLTCQGKI*REPLT
WNLESASSLMTLNLILLKTEPQSQLVLATYHLQP
LH*KFPN*KLQNLPRVQLLLILLILLGIMQWKK
V*AGRSQN*QLQQKGSTKECPWWCLA*PQKNLC
SCTSLPENTTSL*LI*LLKRLLMLL*KQMLSLCV
NGH*NIF*ELREENG*LAISG*PSLLKKEKC*M
SMILKSEEMWSMEETTKVQSEQENPRTERSSGG
*KSVAMGPSPTCPQINWNGWYSCVVLLW*RSFHH
SPLAQVSTQLWLCSQMPGQRTMASMQLGRCVRH
LW*PESGCWTV*HSTSARSWTPT*YPRSPTATT
DCSQPQVQSHRTPRMSLQSGLSRPWELLSLFSPS
TVLATKYFMYISLKRTSGYARVP*RFSA*SLPW
KSAMSTKLW*FFT*EDFKTI*TPPIEQDADSLF
ISPILSIQAVVGLGLEAQSGLASRE*LVSLSLLL
*NPVFTKAESQTLQWKESAWDRLCDLKSE*SLG
SSQMLEWNIGEEILRQVLEMKRKLETWAWWLTP
VIPALWEAKVGRSLEVRSSKPAWPTW*NPISTKN
TEISRSWWWTPVIPATQVAKAGESLQPGRWRLQ
*AKIIPRHSSLGDSETVAQKKKKKKENETRRDF
*KSEIYLLDF*RMCSKTAEDFQEPVSKDSLLIPH
***VKCLLL*LWYIIHSS*NIRPLA*IFHIYKM
TDPTRKEAVAFFEVIFFLCSLLLKPYSFINNFA
C*RKKKCFS*THYPGLFIAVGRTRSSLAPPVCKG
SEDLIVQNTFCKCCAVNTANKLGSKHF

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