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Sequences

Sequence BRCA1.pAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC TCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGTGAAGCAGCATCTGGGTGTG AGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGGGATACCATGCAACATAACCTGATAAA GCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTTCCATCATAAGTGACTCTTCTGCCCTT GAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCCTATAAGCCAGAATCCAGAAGGCCTTT CTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTCATCCCCTTCTAAATGCCCATCATTAGATGA TAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTGTTGATGTGGAGGAGCAACAGCTG GAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGAATCTGGAATCAGCCTCTTCTCTG ATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACCTCTGCATTGAAAGTTCCCCAATTGAA AGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAAGTGTGAGCAGGGAGAAGCCAGAATTG ACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCTCGTGTACAAGTTTGCCAGAAAACACC ACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAACGGACACTGAAATATTTTCTAGG AATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGCATGATTTTGAAGTCAGAGGAGAT GTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCTGTTGCTATGGGCCCTTCA CCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTCACCCTTGGCACAGGTGTCCACCC AATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTG GACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGC CACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTA TGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATG GTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCT GTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAG AGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAGTGGAACAT TGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAG GTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAGAAATTAGCCGGTCATGGTGGT GGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTC CAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGAT TTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGT TGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGT TGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCA TAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATA CGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Multiple exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT L*PWNCENSEDKAADTTSKDVCLH*IG*SSIWV* E*NKRL*RLLRAILSE*HFNHSAEGYHAT*PDK APAGNG*TRSCVRTAWEPAF*QLPFHHK*LFCP *GPAKSRTKHIRKSSINFTEK**IPYKPESRRPF C*QV*GVCR*FYQ*K*RTRSGKVIPF*MPIIR* *VVHAQLLWESSE*KLPISRGAH*GC*CGGATA GRVWATRFDGNILLAKARSRGNPLPGIWNQPLL* *P*I*SF*RQSPRVSSCWQHTIFNLCIESSPIE SCRICPESSCCSYY*YCWV*CNGRKCEQGEARI DSFNRKGQQKNVHGGVWPDPRRIYARVQVCQKTP HHFN*SNY*RDYSCCYENRC*VCV*TDTEIFSR NCGRKMGS*LFLGDPVY*RKKNAE*A*F*SQRR CGQWKKPPRSKASKRIPGQKDLQGARNLLLWALH QHAHRSTGMDGTAVWCFCGEGAFIIHPWHRCPP NCGCAARCLDRGQWLPCNWADV*GTCGDPRVGV GQCSTLPVPGAGHLPDTPDPPQPLLTAASHRYRA TGPQE*AYKVAFPGPGSSSHSSVLLLSWLLNIL CTSA*KGLLAMQGSLKDFLLEVSLGNLP*AQNY GNFSPEKILKPFKRHQLSKMLIHYLSALFFLFRL LLA*GWKHRVAWPQENSWFP*VYFSKTLCSQRQ RVRPFNGRRVLGIDYVT*SQNSPWAVLKCWSGT LGRKF*GRY*K*KGNLKPGHGGSRL*SQHFGRPR WADHWRSGVRNQPGQHGETPSLLKIQKLAGHGG GHL*SQLLRWLRQENHFSPGGGGCSEPRSYHGT PAWVTVRLWLKKKKKKRKMKLEEISKSLRYIC*I SKECVLKQQKIFKNRFPKTVF*FLISNK*NVYC CSSGI*SIPLKI*DLWHEYFISIK*QIPPGRKL LLSLR*FFSFAPCC*NHTAS*IILLAEGRKSVFH KPIIQDCL*LLEGLGLP*PPQCARAVKT*LYKI RFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL SNLGTVRTLRTKQRIQPQKTSVYIELGEAASGC ESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIK LQQEMAELEAVLEQHGSQPSNSYPSIISDSSAL EDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGL SADKFEVSADSSTSKNKEPGVERSSPSKCPSLDD RWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQL EESGPHDLTETSYLPRQDLEGTPYLESGISLFS DDPESDPSEDRAPESARVGNIPSSTSALKVPQLK VAESAQSPAAAHTTDTAGYNAMEESVSREKPEL TASTERVNKRMSMVVSGLTPEEFMLVYKFARKH HITLTNLITEETTHVVMKTDAEFVCERTLKYFLG IAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGD VVNGRNHQGPKRARESQDRKIFRGLEICCYGPF TNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHP IVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVL DSVALYQCQELDTYLIPQIPHSHY*LQPATGTE PQDPKNELTKWPFQALGAPLTLQSFYCPGY*IFY VHQPEKDFWLCKGPLKIFCLKSPLEICHEHKIM VIFHLRRF*NHLNATN*ARC*FIIYQPYSFYSG CCWLRAGSTEWLGLKRIAGFPKFTSLKPCVHKGR ESDPSMEGECLGSIM*LKVRIVLGQFSNVGVEH WGGNSEAGIRNEKET*NLGMVAHACNPSTLGGQ GGQITGGQEFETSLANMVKPHLY*KYRN*PVMVV DTCNPSYSGG*GRRITSAREVEVAVSQDHTTAL QPG*Q*DCGSKKKKKKGK*N*KRFLKV*DIFAR FLKNVF*NSRRFSRTGFQRQSSNSSLVISKMFIV VALVYNPFLLKYKTSGMNISYL*NDRSHQEGSC CFL*GDFFPLLPVAETIQLHK*FCLLKEEKVFF INPLSRTVYSCWKD*VFPSPPSVQGQ*RLDCTKY VL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA TARRELAETSWTGDRLWGFSDNWAPALRRPSPS ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS* SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS LTLEL*EL*GQSSGYNLKRRLSTLNWVKQHLGV RVKQASLKTAQGYPLRVTF*PLSRGIPCNIT** SSSRKWLN*KLC*NSMGASLLTATLPS*VTLLPL RTCEIQNKAHQKKQY*LHRKVVNTL*ARIQKAF LLTSLRCLQIVLPVKIKNQEWKGHPLLNAHH*M IGGTCTVALGVFRIETTHLKRSSLRLLMWRSNSW KSLGHTI*RKHLTCQGKI*REPLTWNLESASSL MTLNLILLKTEPQSQLVLATYHLQPLH*KFPN* KLQNLPRVQLLLILLILLGIMQWKKV*AGRSQN* QLQQKGSTKECPWWCLA*PQKNLCSCTSLPENT TSL*LI*LLKRLLMLL*KQMLSLCVNGH*NIF* ELREENG*LAISG*PSLLKKEKC*MSMILKSEEM WSMEETTKVQSEQENPRTERSSGG*KSVAMGPS PTCPQINWNGWYSCVVLLW*RSFHHSPLAQVST QLWLCSQMPGQRTMASMQLGRCVRHLW*PESGCW TV*HSTSARSWTPT*YPRSPTATTDCSQPQVQS HRTPRMSLQSGLSRPWELLSLFSPSTVLATKYF MYISLKRTSGYARVP*RFSA*SLPWKSAMSTKLW *FFT*EDFKTI*TPPIEQDADSLFISPILSIQA VVGLGLEAQSGLASRE*LVSLSLLL*NPVFTKA ESQTLQWKESAWDRLCDLKSE*SLGSSQMLEWNI GEEILRQVLEMKRKLETWAWWLTPVIPALWEAK VGRSLEVRSSKPAWPTW*NPISTKNTEISRSWW WTPVIPATQVAKAGESLQPGRWRLQ*AKIIPRHS SLGDSETVAQKKKKKKENETRRDF*KSEIYLLD F*RMCSKTAEDFQEPVSKDSLLIPH***VKCLL L*LWYIIHSS*NIRPLA*IFHIYKMTDPTRKEAV AFFEVIFFLCSLLLKPYSFINNFAC*RKKKCFS *THYPGLFIAVGRTRSSLAPPVCKGSEDLIVQN TFCKCCAVNTANKLGSKHF

Sequence BRCA1.qAug05

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Multiple exon skipping

Frame 0

Frame 1

Frame 2

Sequence BRCA1.oAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT GCTCTGGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGAGTGTCC CATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAAGGGCCT TCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCATTTGTG CTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTCTATCAT CCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTCTCTAAC CTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGATCTGATTCTTCTGAAGATACCGTTA ATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAAAGGCTGC TTGTGAATTTTCTGAGACGGATGTAACAAATACTGAACATCATCAACCCAGTAATAATGATTTGAACACCACTGAGAAGCGTGCAGCTGAGAGGCATCCA GAAAAGTATCAGGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTC AGCAGAGGGATACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAG CTACCCTTCCATCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGTATTAACTTCACAGAAAAGTAGTGAA TACCCTATAAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGT CATCCCCTTCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCAT TAAGGTTGTTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCT TACCTGGAATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTT CAACCTCTGCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGA AGAAAGTGTGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTT ATGCTCGTGTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTG TGTGTGAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCT GAATGAGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGG GGGCTAGAAATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGC TTCCATGCAATTGGGCAGATGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACC TGATACCCCAGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGC CCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCC TTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCA CCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAA GAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATT ATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAA CTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGC CAACATGGTGAAACCCCATCTCTACTAAAAATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGA ATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAA AAAAAGGAAAATGAAACTAGAAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAAC CGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACC TCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTG AAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTA GGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGG TAGCAAACACTTCCA

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Multiple exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL LWFIGTERNGFICSSR*RSTKCH*CYAENLRVS HLSGVDQGTCLHKV*PHILQILHAETSQPEERA FTVSFM*E*YNQKEPTRKYEI*STC*RAIENHLC FSA*HRFGVCKQL*FCKKGK*LS*TSKR*SFYH PKYGLQKPCQKTSTE*TRKSFLAGNQSQCPTL* PWNCENSEDKAADTTSKDVCLH*IGI*FF*RYR* *GNLLQCGRSRIVTNHPSRNQG*NQFGFCKKGC L*IF*DGCNKY*TSSTQ***FEHH*EACS*EAS RKVSG*SSIWV*E*NKRL*RLLRAILSE*HFNHS AEGYHAT*PDKAPAGNG*TRSCVRTAWEPAF*Q LPFHHK*LFCP*GPAKSRTKHIRKSINFTEK** IPYKPESRRPFC*QV*GVCR*FYQ*K*RTRSGKV IPF*MPIIR**VVHAQLLWESSE*KLPISRGAH *GC*CGGATAGRVWATRFDGNILLAKARSRGNP LPGIWNQPLL**P*I*SF*RQSPRVSSCWQHTIF NLCIESSPIESCRICPESSCCSYY*YCWV*CNG RKCEQGEARIDSFNRKGQQKNVHGGVWPDPRRI YARVQVCQKTPHHFN*SNY*RDYSCCYENRC*VC V*TDTEIFSRNCGRKMGS*LFLGDPVY*RKKNA E*A*F*SQRRCGQWKKPPRSKASKRIPGQKDLQ GARNLLLWALHQHAHRVSTQLWLCSQMPGQRTMA SMQLGRCVRHLW*PESGCWTV*HSTSARSWTPT *YPRSPTATTDCSQPQVQSHRTPRMSLQSGLSR PWELLSLFSPSTVLATKYFMYISLKRTSGYARVP *RFSA*SLPWKSAMSTKLW*FFT*EDFKTI*TP PIEQDADSLFISPILSIQAVVGLGLEAQSGLAS RE*LVSLSLLL*NPVFTKAESQTLQWKESAWDRL CDLKSE*SLGSSQMLEWNIGEEILRQVLEMKRK LETWAWWLTPVIPALWEAKVGRSLEVRSSKPAW PTW*NPISTKNTEISRSWWWTPVIPATQVAKAGE SLQPGRWRLQ*AKIIPRHSSLGDSETVAQKKKK KKENETRRDF*KSEIYLLDF*RMCSKTAEDFQE PVSKDSLLIPH***VKCLLL*LWYIIHSS*NIRP LA*IFHIYKMTDPTRKEAVAFFEVIFFLCSLLL KPYSFINNFAC*RKKKCFS*THYPGLFIAVGRT RSSLAPPVCKGSEDLIVQNTFCKCCAVNTANKLG SKHF

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL CSGSLEQKEMDLSALRVEEVQNVINAMQKILECP ICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGP SQCPLCKNDITKRSLQESTRFSQLVEELLKIIC AFQLDTGLEYANSYNFAKKENNSPEHLKDEVSII QSMGYRNRAKRLLQSEPENPSLQETSLSVQLSN LGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTV NKATYCSVGDQELLQITPQGTRDEISLDSAKKAA CEFSETDVTNTEHHQPSNNDLNTTEKRAAERHP EKYQGEAASGCESETSVSEDCSGLSSQSDILTT QQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNS YPSIISDSSALEDLRNPEQSTSEKVLTSQKSSE YPISQNPEGLSADKFEVSADSSTSKNKEPGVER SSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELI KVVDVEEQQLEESGPHDLTETSYLPRQDLEGTP YLESGISLFSDDPESDPSEDRAPESARVGNIPS STSALKVPQLKVAESAQSPAAAHTTDTAGYNAME ESVSREKPELTASTERVNKRMSMVVSGLTPEEF MLVYKFARKHHITLTNLITEETTHVVMKTDAEF VCERTLKYFLGIAGGKWVVSYFWVTQSIKERKML NEHDFEVRGDVVNGRNHQGPKRARESQDRKIFR GLEICCYGPFTNMPTGCPPNCGCAARCLDRGQW LPCNWADV*GTCGDPRVGVGQCSTLPVPGAGHLP DTPDPPQPLLTAASHRYRATGPQE*AYKVAFPG PGSSSHSSVLLLSWLLNILCTSA*KGLLAMQGS LKDFLLEVSLGNLP*AQNYGNFSPEKILKPFKRH QLSKMLIHYLSALFFLFRLLLA*GWKHRVAWPQ ENSWFP*VYFSKTLCSQRQRVRPFNGRRVLGID YVT*SQNSPWAVLKCWSGTLGRKF*GRY*K*KGN LKPGHGGSRL*SQHFGRPRWADHWRSGVRNQPG QHGETPSLLKIQKLAGHGGGHL*SQLLRWLRQE NHFSPGGGGCSEPRSYHGTPAWVTVRLWLKKKKK KRKMKLEEISKSLRYIC*ISKECVLKQQKIFKN RFPKTVF*FLISNK*NVYCCSSGI*SIPLKI*D LWHEYFISIK*QIPPGRKLLLSLR*FFSFAPCC* NHTAS*IILLAEGRKSVFHKPIIQDCL*LLEGL GLP*PPQCARAVKT*LYKIRFVNVVLLTLQINL VANTS

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA TARRELAETSWTGDRLWGFSDNWAPALRRPSPS ALVHWNRKKWIYLLFALKKYKMSLMLCRKS*SV PSVWS*SRNLSPQSVTTYFANFAC*NFSTRRKGL HSVLYVRMI*PKGAYKKVRDLVNLLKSY*KSFV LFSLTQVWSMQTAIILQKRKITLLNI*KMKFLS SKVWATETVPKDFYRVNPKILPCRKPVSVSNSLT LEL*EL*GQSSGYNLKRRLSTLNWDLILLKIPL IRQLIAVWEIKNCYKSPLKEPGMKSVWILQKRL LVNFLRRM*QILNIINPVIMI*TPLRSVQLRGIQ KSIRVKQHLGVRVKQASLKTAQGYPLRVTF*PL SRGIPCNIT**SSSRKWLN*KLC*NSMGASLLT ATLPS*VTLLPLRTCEIQNKAHQKKY*LHRKVVN TL*ARIQKAFLLTSLRCLQIVLPVKIKNQEWKG HPLLNAHH*MIGGTCTVALGVFRIETTHLKRSS LRLLMWRSNSWKSLGHTI*RKHLTCQGKI*REPL TWNLESASSLMTLNLILLKTEPQSQLVLATYHL QPLH*KFPN*KLQNLPRVQLLLILLILLGIMQW KKV*AGRSQN*QLQQKGSTKECPWWCLA*PQKNL CSCTSLPENTTSL*LI*LLKRLLMLL*KQMLSL CVNGH*NIF*ELREENG*LAISG*PSLLKKEKC *MSMILKSEEMWSMEETTKVQSEQENPRTERSSG G*KSVAMGPSPTCPQGVHPIVVVQPDAWTEDNG FHAIGQMCEAPVVTREWVLDSVALYQCQELDTY LIPQIPHSHY*LQPATGTEPQDPKNELTKWPFQA LGAPLTLQSFYCPGY*IFYVHQPEKDFWLCKGP LKIFCLKSPLEICHEHKIMVIFHLRRF*NHLNA TN*ARC*FIIYQPYSFYSGCCWLRAGSTEWLGLK RIAGFPKFTSLKPCVHKGRESDPSMEGECLGSI M*LKVRIVLGQFSNVGVEHWGGNSEAGIRNEKE T*NLGMVAHACNPSTLGGQGGQITGGQEFETSLA NMVKPHLY*KYRN*PVMVVDTCNPSYSGG*GRR ITSAREVEVAVSQDHTTALQPG*Q*DCGSKKKK KKGK*N*KRFLKV*DIFARFLKNVF*NSRRFSRT GFQRQSSNSSLVISKMFIVVALVYNPFLLKYKT SGMNISYL*NDRSHQEGSCCFL*GDFFPLLPVA ETIQLHK*FCLLKEEKVFFINPLSRTVYSCWKD* VFPSPPSVQGQ*RLDCTKYVL*MLCC*HCK*TW *QTLP

Sequence BRCA1.lAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC TCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGATCTGATTCTTCTGAAGATA CCGTTAATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAAA GGCTGCTTGTGAATTTTCTGAGACGGATGTAACAAATACTGAACATCATCAACCCAGTAATAATGATTTGAACACCACTGAGAAGCGTGCAGCTGAGAGG CATCCAGAAAAGTATCAGGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAA CCACTCAGCAGAGGGATACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTC TAACAGCTACCCTTCCATCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGTATTAACTTCACAGAAAAGT AGTGAATACCCTATAAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGG AAAGGTCATCCCCTTCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGA GCTCATTAAGGTTGTTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGA ACCCCTTACCTGGAATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATAC CATCTTCAACCTCTGCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGC AATGGAAGAAAGTGTGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAA GAATTTATGCTCGTGTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTG AGTTTGTGTGTGAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAA AATGCTGAATGAGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATC TTCAGGGGGCTAGAAATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGG AGCTTTCATCATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGAT GTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCAC AGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTC TTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAA GTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGA TTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTA AGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAAT AGTCCTTGGGCAGTTCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTG GCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATC TCTACTAAAAATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGT GGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAG AAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTT CTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATA TCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAA TAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCA GTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Multiple exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT L*PWNCENSEDKAADTTSKDVCLH*IGI*FF*RY R**GNLLQCGRSRIVTNHPSRNQG*NQFGFCKK GCL*IF*DGCNKY*TSSTQ***FEHH*EACS*E ASRKVSG*SSIWV*E*NKRL*RLLRAILSE*HFN HSAEGYHAT*PDKAPAGNG*TRSCVRTAWEPAF *QLPFHHK*LFCP*GPAKSRTKHIRKSINFTEK **IPYKPESRRPFC*QV*GVCR*FYQ*K*RTRSG KVIPF*MPIIR**VVHAQLLWESSE*KLPISRG AH*GC*CGGATAGRVWATRFDGNILLAKARSRG NPLPGIWNQPLL**P*I*SF*RQSPRVSSCWQHT IFNLCIESSPIESCRICPESSCCSYY*YCWV*C NGRKCEQGEARIDSFNRKGQQKNVHGGVWPDPR RIYARVQVCQKTPHHFN*SNY*RDYSCCYENRC* VCV*TDTEIFSRNCGRKMGS*LFLGDPVY*RKK NAE*A*F*SQRRCGQWKKPPRSKASKRIPGQKD LQGARNLLLWALHQHAHRSTGMDGTAVWCFCGEG AFIIHPWHRCPPNCGCAARCLDRGQWLPCNWAD V*GTCGDPRVGVGQCSTLPVPGAGHLPDTPDPP QPLLTAASHRYRATGPQE*AYKVAFPGPGSSSHS SVLLLSWLLNILCTSA*KGLLAMQGSLKDFLLE VSLGNLP*AQNYGNFSPEKILKPFKRHQLSKML IHYLSALFFLFRLLLA*GWKHRVAWPQENSWFP* VYFSKTLCSQRQRVRPFNGRRVLGIDYVT*SQN SPWAVLKCWSGTLGRKF*GRY*K*KGNLKPGHG GSRL*SQHFGRPRWADHWRSGVRNQPGQHGETPS LLKIQKLAGHGGGHL*SQLLRWLRQENHFSPGG GGCSEPRSYHGTPAWVTVRLWLKKKKKKRKMKL EEISKSLRYIC*ISKECVLKQQKIFKNRFPKTVF *FLISNK*NVYCCSSGI*SIPLKI*DLWHEYFI SIK*QIPPGRKLLLSLR*FFSFAPCC*NHTAS* IILLAEGRKSVFHKPIIQDCL*LLEGLGLP*PPQ CARAVKT*LYKIRFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL SNLGTVRTLRTKQRIQPQKTSVYIELGSDSSED TVNKATYCSVGDQELLQITPQGTRDEISLDSAKK AACEFSETDVTNTEHHQPSNNDLNTTEKRAAER HPEKYQGEAASGCESETSVSEDCSGLSSQSDIL TTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPS NSYPSIISDSSALEDLRNPEQSTSEKVLTSQKS SEYPISQNPEGLSADKFEVSADSSTSKNKEPGV ERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEE LIKVVDVEEQQLEESGPHDLTETSYLPRQDLEG TPYLESGISLFSDDPESDPSEDRAPESARVGNI PSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNA MEESVSREKPELTASTERVNKRMSMVVSGLTPE EFMLVYKFARKHHITLTNLITEETTHVVMKTDA EFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERK MLNEHDFEVRGDVVNGRNHQGPKRARESQDRKI FRGLEICCYGPFTNMPTDQLEWMVQLCGASVVK ELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQM CEAPVVTREWVLDSVALYQCQELDTYLIPQIPH SHY*LQPATGTEPQDPKNELTKWPFQALGAPLT LQSFYCPGY*IFYVHQPEKDFWLCKGPLKIFCLK SPLEICHEHKIMVIFHLRRF*NHLNATN*ARC* FIIYQPYSFYSGCCWLRAGSTEWLGLKRIAGFP KFTSLKPCVHKGRESDPSMEGECLGSIM*LKVRI VLGQFSNVGVEHWGGNSEAGIRNEKET*NLGMV AHACNPSTLGGQGGQITGGQEFETSLANMVKPH LY*KYRN*PVMVVDTCNPSYSGG*GRRITSAREV EVAVSQDHTTALQPG*Q*DCGSKKKKKKGK*N* KRFLKV*DIFARFLKNVF*NSRRFSRTGFQRQS SNSSLVISKMFIVVALVYNPFLLKYKTSGMNISY L*NDRSHQEGSCCFL*GDFFPLLPVAETIQLHK *FCLLKEEKVFFINPLSRTVYSCWKD*VFPSPP SVQGQ*RLDCTKYVL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA TARRELAETSWTGDRLWGFSDNWAPALRRPSPS ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS* SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS LTLEL*EL*GQSSGYNLKRRLSTLNWDLILLKI PLIRQLIAVWEIKNCYKSPLKEPGMKSVWILQK RLLVNFLRRM*QILNIINPVIMI*TPLRSVQLRG IQKSIRVKQHLGVRVKQASLKTAQGYPLRVTF* PLSRGIPCNIT**SSSRKWLN*KLC*NSMGASL LTATLPS*VTLLPLRTCEIQNKAHQKKY*LHRKV VNTL*ARIQKAFLLTSLRCLQIVLPVKIKNQEW KGHPLLNAHH*MIGGTCTVALGVFRIETTHLKR SSLRLLMWRSNSWKSLGHTI*RKHLTCQGKI*RE PLTWNLESASSLMTLNLILLKTEPQSQLVLATY HLQPLH*KFPN*KLQNLPRVQLLLILLILLGIM QWKKV*AGRSQN*QLQQKGSTKECPWWCLA*PQK NLCSCTSLPENTTSL*LI*LLKRLLMLL*KQML SLCVNGH*NIF*ELREENG*LAISG*PSLLKKE KC*MSMILKSEEMWSMEETTKVQSEQENPRTERS SGG*KSVAMGPSPTCPQINWNGWYSCVVLLW*R SFHHSPLAQVSTQLWLCSQMPGQRTMASMQLGR CVRHLW*PESGCWTV*HSTSARSWTPT*YPRSPT ATTDCSQPQVQSHRTPRMSLQSGLSRPWELLSL FSPSTVLATKYFMYISLKRTSGYARVP*RFSA* SLPWKSAMSTKLW*FFT*EDFKTI*TPPIEQDAD SLFISPILSIQAVVGLGLEAQSGLASRE*LVSL SLLL*NPVFTKAESQTLQWKESAWDRLCDLKSE *SLGSSQMLEWNIGEEILRQVLEMKRKLETWAWW LTPVIPALWEAKVGRSLEVRSSKPAWPTW*NPI STKNTEISRSWWWTPVIPATQVAKAGESLQPGR WRLQ*AKIIPRHSSLGDSETVAQKKKKKKENETR RDF*KSEIYLLDF*RMCSKTAEDFQEPVSKDSL LIPH***VKCLLL*LWYIIHSS*NIRPLA*IFH IYKMTDPTRKEAVAFFEVIFFLCSLLLKPYSFIN NFAC*RKKKCFS*THYPGLFIAVGRTRSSLAPP VCKGSEDLIVQNTFCKCCAVNTANKLGSKHF