Sequences - Rnomics 📊 Palace

        ☰
    
        Rnomics 📊 Palace
    
                       Back to Rnomics Platform
            
                       Open Session

1 warning:

Access restricted to public data.
Please sign in at Rnomics Platform to access your data.

Navigation

Home

Sequences

Sequence BRCA1.pAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC TCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGTGAAGCAGCATCTGGGTGTG AGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGGGATACCATGCAACATAACCTGATAAA GCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTTCCATCATAAGTGACTCTTCTGCCCTT GAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCCTATAAGCCAGAATCCAGAAGGCCTTT CTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTCATCCCCTTCTAAATGCCCATCATTAGATGA TAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTGTTGATGTGGAGGAGCAACAGCTG GAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGAATCTGGAATCAGCCTCTTCTCTG ATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACCTCTGCATTGAAAGTTCCCCAATTGAA AGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAAGTGTGAGCAGGGAGAAGCCAGAATTG ACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCTCGTGTACAAGTTTGCCAGAAAACACC ACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAACGGACACTGAAATATTTTCTAGG AATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGCATGATTTTGAAGTCAGAGGAGAT GTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCTGTTGCTATGGGCCCTTCA CCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTCACCCTTGGCACAGGTGTCCACCC AATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTG GACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGC CACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTA TGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATG GTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCT GTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAG AGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAGTGGAACAT TGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAG GTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAGAAATTAGCCGGTCATGGTGGT GGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTC CAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGAT TTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGT TGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGT TGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCA TAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATA CGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Multiple exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT L*PWNCENSEDKAADTTSKDVCLH*IG*SSIWV* E*NKRL*RLLRAILSE*HFNHSAEGYHAT*PDK APAGNG*TRSCVRTAWEPAF*QLPFHHK*LFCP *GPAKSRTKHIRKSSINFTEK**IPYKPESRRPF C*QV*GVCR*FYQ*K*RTRSGKVIPF*MPIIR* *VVHAQLLWESSE*KLPISRGAH*GC*CGGATA GRVWATRFDGNILLAKARSRGNPLPGIWNQPLL* *P*I*SF*RQSPRVSSCWQHTIFNLCIESSPIE SCRICPESSCCSYY*YCWV*CNGRKCEQGEARI DSFNRKGQQKNVHGGVWPDPRRIYARVQVCQKTP HHFN*SNY*RDYSCCYENRC*VCV*TDTEIFSR NCGRKMGS*LFLGDPVY*RKKNAE*A*F*SQRR CGQWKKPPRSKASKRIPGQKDLQGARNLLLWALH QHAHRSTGMDGTAVWCFCGEGAFIIHPWHRCPP NCGCAARCLDRGQWLPCNWADV*GTCGDPRVGV GQCSTLPVPGAGHLPDTPDPPQPLLTAASHRYRA TGPQE*AYKVAFPGPGSSSHSSVLLLSWLLNIL CTSA*KGLLAMQGSLKDFLLEVSLGNLP*AQNY GNFSPEKILKPFKRHQLSKMLIHYLSALFFLFRL LLA*GWKHRVAWPQENSWFP*VYFSKTLCSQRQ RVRPFNGRRVLGIDYVT*SQNSPWAVLKCWSGT LGRKF*GRY*K*KGNLKPGHGGSRL*SQHFGRPR WADHWRSGVRNQPGQHGETPSLLKIQKLAGHGG GHL*SQLLRWLRQENHFSPGGGGCSEPRSYHGT PAWVTVRLWLKKKKKKRKMKLEEISKSLRYIC*I SKECVLKQQKIFKNRFPKTVF*FLISNK*NVYC CSSGI*SIPLKI*DLWHEYFISIK*QIPPGRKL LLSLR*FFSFAPCC*NHTAS*IILLAEGRKSVFH KPIIQDCL*LLEGLGLP*PPQCARAVKT*LYKI RFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL SNLGTVRTLRTKQRIQPQKTSVYIELGEAASGC ESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIK LQQEMAELEAVLEQHGSQPSNSYPSIISDSSAL EDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGL SADKFEVSADSSTSKNKEPGVERSSPSKCPSLDD RWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQL EESGPHDLTETSYLPRQDLEGTPYLESGISLFS DDPESDPSEDRAPESARVGNIPSSTSALKVPQLK VAESAQSPAAAHTTDTAGYNAMEESVSREKPEL TASTERVNKRMSMVVSGLTPEEFMLVYKFARKH HITLTNLITEETTHVVMKTDAEFVCERTLKYFLG IAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGD VVNGRNHQGPKRARESQDRKIFRGLEICCYGPF TNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHP IVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVL DSVALYQCQELDTYLIPQIPHSHY*LQPATGTE PQDPKNELTKWPFQALGAPLTLQSFYCPGY*IFY VHQPEKDFWLCKGPLKIFCLKSPLEICHEHKIM VIFHLRRF*NHLNATN*ARC*FIIYQPYSFYSG CCWLRAGSTEWLGLKRIAGFPKFTSLKPCVHKGR ESDPSMEGECLGSIM*LKVRIVLGQFSNVGVEH WGGNSEAGIRNEKET*NLGMVAHACNPSTLGGQ GGQITGGQEFETSLANMVKPHLY*KYRN*PVMVV DTCNPSYSGG*GRRITSAREVEVAVSQDHTTAL QPG*Q*DCGSKKKKKKGK*N*KRFLKV*DIFAR FLKNVF*NSRRFSRTGFQRQSSNSSLVISKMFIV VALVYNPFLLKYKTSGMNISYL*NDRSHQEGSC CFL*GDFFPLLPVAETIQLHK*FCLLKEEKVFF INPLSRTVYSCWKD*VFPSPPSVQGQ*RLDCTKY VL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA TARRELAETSWTGDRLWGFSDNWAPALRRPSPS ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS* SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS LTLEL*EL*GQSSGYNLKRRLSTLNWVKQHLGV RVKQASLKTAQGYPLRVTF*PLSRGIPCNIT** SSSRKWLN*KLC*NSMGASLLTATLPS*VTLLPL RTCEIQNKAHQKKQY*LHRKVVNTL*ARIQKAF LLTSLRCLQIVLPVKIKNQEWKGHPLLNAHH*M IGGTCTVALGVFRIETTHLKRSSLRLLMWRSNSW KSLGHTI*RKHLTCQGKI*REPLTWNLESASSL MTLNLILLKTEPQSQLVLATYHLQPLH*KFPN* KLQNLPRVQLLLILLILLGIMQWKKV*AGRSQN* QLQQKGSTKECPWWCLA*PQKNLCSCTSLPENT TSL*LI*LLKRLLMLL*KQMLSLCVNGH*NIF* ELREENG*LAISG*PSLLKKEKC*MSMILKSEEM WSMEETTKVQSEQENPRTERSSGG*KSVAMGPS PTCPQINWNGWYSCVVLLW*RSFHHSPLAQVST QLWLCSQMPGQRTMASMQLGRCVRHLW*PESGCW TV*HSTSARSWTPT*YPRSPTATTDCSQPQVQS HRTPRMSLQSGLSRPWELLSLFSPSTVLATKYF MYISLKRTSGYARVP*RFSA*SLPWKSAMSTKLW *FFT*EDFKTI*TPPIEQDADSLFISPILSIQA VVGLGLEAQSGLASRE*LVSLSLLL*NPVFTKA ESQTLQWKESAWDRLCDLKSE*SLGSSQMLEWNI GEEILRQVLEMKRKLETWAWWLTPVIPALWEAK VGRSLEVRSSKPAWPTW*NPISTKNTEISRSWW WTPVIPATQVAKAGESLQPGRWRLQ*AKIIPRHS SLGDSETVAQKKKKKKENETRRDF*KSEIYLLD F*RMCSKTAEDFQEPVSKDSLLIPH***VKCLL L*LWYIIHSS*NIRPLA*IFHIYKMTDPTRKEAV AFFEVIFFLCSLLLKPYSFINNFAC*RKKKCFS *THYPGLFIAVGRTRSSLAPPVCKGSEDLIVQN TFCKCCAVNTANKLGSKHF

Sequence BRCA1.mAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC TCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGATCTGATTCTTCTGAAGATA CCGTTAATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAAA GGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGGGAT ACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTTCCA TCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCCTAT AAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTCATCCCCT TCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTG TTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGA ATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACCTCT GCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAAGTG TGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCTCGT GTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAA CGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGC ATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGA AATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTC ACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCACCTG TGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGACT GCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTAC TGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAA TCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCA GCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTA AAACCCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGT TCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAA TCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAC AGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGA GCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATTTCTAAA AGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTA GTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACA GATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCT GAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAG TGAAGACTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Multiple exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT L*PWNCENSEDKAADTTSKDVCLH*IGI*FF*RY R**GNLLQCGRSRIVTNHPSRNQG*NQFGFCKK G*SSIWV*E*NKRL*RLLRAILSE*HFNHSAEG YHAT*PDKAPAGNG*TRSCVRTAWEPAF*QLPFH HK*LFCP*GPAKSRTKHIRKSSINFTEK**IPY KPESRRPFC*QV*GVCR*FYQ*K*RTRSGKVIP F*MPIIR**VVHAQLLWESSE*KLPISRGAH*GC *CGGATAGRVWATRFDGNILLAKARSRGNPLPG IWNQPLL**P*I*SF*RQSPRVSSCWQHTIFNL CIESSPIESCRICPESSCCSYY*YCWV*CNGRKC EQGEARIDSFNRKGQQKNVHGGVWPDPRRIYAR VQVCQKTPHHFN*SNY*RDYSCCYENRC*VCV* TDTEIFSRNCGRKMGS*LFLGDPVY*RKKNAE*A *F*SQRRCGQWKKPPRSKASKRIPGQKDLQGAR NLLLWALHQHAHRSTGMDGTAVWCFCGEGAFII HPWHRCPPNCGCAARCLDRGQWLPCNWADV*GTC GDPRVGVGQCSTLPVPGAGHLPDTPDPPQPLLT AASHRYRATGPQE*AYKVAFPGPGSSSHSSVLL LSWLLNILCTSA*KGLLAMQGSLKDFLLEVSLGN LP*AQNYGNFSPEKILKPFKRHQLSKMLIHYLS ALFFLFRLLLA*GWKHRVAWPQENSWFP*VYFS KTLCSQRQRVRPFNGRRVLGIDYVT*SQNSPWAV LKCWSGTLGRKF*GRY*K*KGNLKPGHGGSRL* SQHFGRPRWADHWRSGVRNQPGQHGETPSLLKI QKLAGHGGGHL*SQLLRWLRQENHFSPGGGGCSE PRSYHGTPAWVTVRLWLKKKKKKRKMKLEEISK SLRYIC*ISKECVLKQQKIFKNRFPKTVF*FLI SNK*NVYCCSSGI*SIPLKI*DLWHEYFISIK*Q IPPGRKLLLSLR*FFSFAPCC*NHTAS*IILLA EGRKSVFHKPIIQDCL*LLEGLGLP*PPQCARA VKT*LYKIRFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL SNLGTVRTLRTKQRIQPQKTSVYIELGSDSSED TVNKATYCSVGDQELLQITPQGTRDEISLDSAKK GEAASGCESETSVSEDCSGLSSQSDILTTQQRD TMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPS IISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPI SQNPEGLSADKFEVSADSSTSKNKEPGVERSSP SKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKV VDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLE SGISLFSDDPESDPSEDRAPESARVGNIPSSTS ALKVPQLKVAESAQSPAAAHTTDTAGYNAMEES VSREKPELTASTERVNKRMSMVVSGLTPEEFMLV YKFARKHHITLTNLITEETTHVVMKTDAEFVCE RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNE HDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLE ICCYGPFTNMPTDQLEWMVQLCGASVVKELSSF TLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAP VVTREWVLDSVALYQCQELDTYLIPQIPHSHY*L QPATGTEPQDPKNELTKWPFQALGAPLTLQSFY CPGY*IFYVHQPEKDFWLCKGPLKIFCLKSPLE ICHEHKIMVIFHLRRF*NHLNATN*ARC*FIIYQ PYSFYSGCCWLRAGSTEWLGLKRIAGFPKFTSL KPCVHKGRESDPSMEGECLGSIM*LKVRIVLGQ FSNVGVEHWGGNSEAGIRNEKET*NLGMVAHACN PSTLGGQGGQITGGQEFETSLANMVKPHLY*KY RN*PVMVVDTCNPSYSGG*GRRITSAREVEVAV SQDHTTALQPG*Q*DCGSKKKKKKGK*N*KRFLK V*DIFARFLKNVF*NSRRFSRTGFQRQSSNSSL VISKMFIVVALVYNPFLLKYKTSGMNISYL*ND RSHQEGSCCFL*GDFFPLLPVAETIQLHK*FCLL KEEKVFFINPLSRTVYSCWKD*VFPSPPSVQGQ *RLDCTKYVL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA TARRELAETSWTGDRLWGFSDNWAPALRRPSPS ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS* SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS LTLEL*EL*GQSSGYNLKRRLSTLNWDLILLKI PLIRQLIAVWEIKNCYKSPLKEPGMKSVWILQK RVKQHLGVRVKQASLKTAQGYPLRVTF*PLSRGI PCNIT**SSSRKWLN*KLC*NSMGASLLTATLP S*VTLLPLRTCEIQNKAHQKKQY*LHRKVVNTL *ARIQKAFLLTSLRCLQIVLPVKIKNQEWKGHPL LNAHH*MIGGTCTVALGVFRIETTHLKRSSLRL LMWRSNSWKSLGHTI*RKHLTCQGKI*REPLTW NLESASSLMTLNLILLKTEPQSQLVLATYHLQPL H*KFPN*KLQNLPRVQLLLILLILLGIMQWKKV *AGRSQN*QLQQKGSTKECPWWCLA*PQKNLCS CTSLPENTTSL*LI*LLKRLLMLL*KQMLSLCVN GH*NIF*ELREENG*LAISG*PSLLKKEKC*MS MILKSEEMWSMEETTKVQSEQENPRTERSSGG* KSVAMGPSPTCPQINWNGWYSCVVLLW*RSFHHS PLAQVSTQLWLCSQMPGQRTMASMQLGRCVRHL W*PESGCWTV*HSTSARSWTPT*YPRSPTATTD CSQPQVQSHRTPRMSLQSGLSRPWELLSLFSPST VLATKYFMYISLKRTSGYARVP*RFSA*SLPWK SAMSTKLW*FFT*EDFKTI*TPPIEQDADSLFI SPILSIQAVVGLGLEAQSGLASRE*LVSLSLLL* NPVFTKAESQTLQWKESAWDRLCDLKSE*SLGS SQMLEWNIGEEILRQVLEMKRKLETWAWWLTPV IPALWEAKVGRSLEVRSSKPAWPTW*NPISTKNT EISRSWWWTPVIPATQVAKAGESLQPGRWRLQ* AKIIPRHSSLGDSETVAQKKKKKKENETRRDF* KSEIYLLDF*RMCSKTAEDFQEPVSKDSLLIPH* **VKCLLL*LWYIIHSS*NIRPLA*IFHIYKMT DPTRKEAVAFFEVIFFLCSLLLKPYSFINNFAC *RKKKCFS*THYPGLFIAVGRTRSSLAPPVCKGS EDLIVQNTFCKCCAVNTANKLGSKHF