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Sequences

Sequence BRCA1.pAug05

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Single exon skipping

Frame 0

Frame 1

Frame 2

Sequence BRCA1.dAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC TCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGCTGCTTGTGAATTTTCTGAGA CGGATGTAACAAATACTGAACATCATCAACCCAGTAATAATGATTTGAACACCACTGAGAAGCGTGCAGCTGAGAGGCATCCAGAAAAGTATCAGGGTAG TTCTGTTTCAAACTTGCATGTGGAGCCATGTGGCACAAATACTCATGCCAGCTCATTACAGCATGAGAACAGCAGTTTATTACTCACTAAAGACAGAATG AATGTAGAAAAGGCTGAATTCTGTAATAAAAGCAAACAGCCTGGCTTAGCAAGGAGCCAACATAACAGATGGGCTGGAAGTAAGGAAACATGTAATGATA GGCGGACTCCCAGCACAGAAAAAAAGGTAGATCTGAATGCTGATCCCCTGTGTGAGAGAAAAGAATGGAATAAGCAGAAACTGCCATGCTCAGAGAATCC TAGAGATACTGAAGATGTTCCTTGGATAACACTAAATAGCAGCATTCAGAAAGTTAATGAGTGGTTTTCCAGAAGTGATGAACTGTTAGGTTCTGATGAC TCACATGATGGGGAGTCTGAATCAAATGCCAAAGTAGCTGATGTATTGGACGTTCTAAATGAGGTAGATGAATATTCTGGTTCTTCAGAGAAAATAGACT TACTGGCCAGTGATCCTCATGAGGCTTTAATATGTAAAAGTGAAAGAGTTCACTCCAAATCAGTAGAGAGTAATATTGAAGACAAAATATTTGGGAAAAC CTATCGGAAGAAGGCAAGCCTCCCCAACTTAAGCCATGTAACTGAAAATCTAATTATAGGAGCATTTGTTACTGAGCCACAGATAATACAAGAGCGTCCC CTCACAAATAAATTAAAGCGTAAAAGGAGACCTACATCAGGCCTTCATCCTGAGGATTTTATCAAGAAAGCAGATTTGGCAGTTCAAAAGACTCCTGAAA TGATAAATCAGGGAACTAACCAAACGGAGCAGAATGGTCAAGTGATGAATATTACTAATAGTGGTCATGAGAATAAAACAAAAGGTGATTCTATTCAGAA TGAGAAAAATCCTAACCCAATAGAATCACTCGAAAAAGAATCTGCTTTCAAAACGAAAGCTGAACCTATAAGCAGCAGTATAAGCAATATGGAACTCGAA TTAAATATCCACAATTCAAAAGCACCTAAAAAGAATAGGCTGAGGAGGAAGTCTTCTACCAGGCATATTCATGCGCTTGAACTAGTAGTCAGTAGAAATC TAAGCCCACCTAATTGTACTGAATTGCAAATTGATAGTTGTTCTAGCAGTGAAGAGATAAAGAAAAAAAAGTACAACCAAATGCCAGTCAGGCACAGCAG AAACCTACAACTCATGGAAGGTAAAGAACCTGCAACTGGAGCCAAGAAGAGTAACAAGCCAAATGAACAGACAAGTAAAAGACATGACAGCGATACTTTC CCAGAGCTGAAGTTAACAAATGCACCTGGTTCTTTTACTAAGTGTTCAAATACCAGTGAACTTAAAGAATTTGTCAATCCTAGCCTTCCAAGAGAAGAAA AAGAAGAGAAACTAGAAACAGTTAAAGTGTCTAATAATGCTGAAGACCCCAAAGATCTCATGTTAAGTGGAGAAAGGGTTTTGCAAACTGAAAGATCTGT AGAGAGTAGCAGTATTTCATTGGTACCTGGTACTGATTATGGCACTCAGGAAAGTATCTCGTTACTGGAAGTTAGCACTCTAGGGAAGGCAAAAACAGAA CCAAATAAATGTGTGAGTCAGTGTGCAGCATTTGAAAACCCCAAGGGACTAATTCATGGTTGTTCCAAAGATAATAGAAATGACACAGAAGGCTTTAAGT ATCCATTGGGACATGAAGTTAACCACAGTCGGGAAACAAGCATAGAAATGGAAGAAAGTGAACTTGATGCTCAGTATTTGCAGAATACATTCAAGGTTTC AAAGCGCCAGTCATTTGCTCCGTTTTCAAATCCAGGAAATGCAGAAGAGGAATGTGCAACATTCTCTGCCCACTCTGGGTCCTTAAAGAAACAAAGTCCA AAAGTCACTTTTGAATGTGAACAAAAGGAAGAAAATCAAGGAAAGAATGAGTCTAATATCAAGCCTGTACAGACAGTTAATATCACTGCAGGCTTTCCTG TGGTTGGTCAGAAAGATAAGCCAGTTGATAATGCCAAATGTAGTATCAAAGGAGGCTCTAGGTTTTGTCTATCATCTCAGTTCAGAGGCAACGAAACTGG ACTCATTACTCCAAATAAACATGGACTTTTACAAAACCCATATCGTATACCACCACTTTTTCCCATCAAGTCATTTGTTAAAACTAAATGTAAGAAAAAT CTGCTAGAGGAAAACTTTGAGGAACATTCAATGTCACCTGAAAGAGAAATGGGAAATGAGAACATTCCAAGTACAGTGAGCACAATTAGCCGTAATAACA TTAGAGAAAATGTTTTTAAAGAAGCCAGCTCAAGCAATATTAATGAAGTAGGTTCCAGTACTAATGAAGTGGGCTCCAGTATTAATGAAATAGGTTCCAG TGATGAAAACATTCAAGCAGAACTAGGTAGAAACAGAGGGCCAAAATTGAATGCTATGCTTAGATTAGGGGTTTTGCAACCTGAGGTCTATAAACAAAGT CTTCCTGGAAGTAATTGTAAGCATCCTGAAATAAAAAAGCAAGAATATGAAGAAGTAGTTCAGACTGTTAATACAGATTTCTCTCCATATCTGATTTCAG ATAACTTAGAACAGCCTATGGGAAGTAGTCATGCATCTCAGGTTTGTTCTGAGACACCTGATGACCTGTTAGATGATGGTGAAATAAAGGAAGATACTAG TTTTGCTGAAAATGACATTAAGGAAAGTTCTGCTGTTTTTAGCAAAAGCGTCCAGAAAGGAGAGCTTAGCAGGAGTCCTAGCCCTTTCACCCATACACAT TTGGCTCAGGGTTACCGAAGAGGGGCCAAGAAATTAGAGTCCTCAGAAGAGAACTTATCTAGTGAGGATGAAGAGCTTCCCTGCTTCCAACACTTGTTAT TTGGTAAAGTAAACAATATACCTTCTCAGTCTACTAGGCATAGCACCGTTGCTACCGAGTGTCTGTCTAAGAACACAGAGGAGAATTTATTATCATTGAA GAATAGCTTAAATGACTGCAGTAACCAGGTAATATTGGCAAAGGCATCTCAGGAACATCACCTTAGTGAGGAAACAAAATGTTCTGCTAGCTTGTTTTCT TCACAGTGCAGTGAATTGGAAGACTTGACTGCAAATACAAACACCCAGGATCCTTTCTTGATTGGTTCTTCCAAACAAATGAGGCATCAGTCTGAAAGCC AGGGAGTTGGTCTGAGTGACAAGGAATTGGTTTCAGATGATGAAGAAAGAGGAACGGGCTTGGAAGAAAATAATCAAGAAGAGCAAAGCATGGATTCAAA CTTAGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGG GATACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTT CCATCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCC TATAAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTCATCC CCTTCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGG TTGTTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCT GGAATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACC TCTGCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAA GTGTGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCT CGTGTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGT GAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATG AGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCT AGAAATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCA TTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCAC CTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTG ACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTC TACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGG AAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTA TCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCT CTAAAACCCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGC AGTTCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTG TAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAA TACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAG TGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATTTCT AAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTTCTAATTCCTCA TTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATG ACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTT GCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGG CAGTGAAGACTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Single exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT L*PWNCENSEDKAADTTSKDVCLH*IGCL*IF*D GCNKY*TSSTQ***FEHH*EACS*EASRKVSG* FCFKLACGAMWHKYSCQLITA*EQQFITH*RQN ECRKG*IL**KQTAWLSKEPT*QMGWK*GNM*** ADSQHRKKGRSEC*SPV*EKRME*AETAMLRES *RY*RCSLDNTK*QHSES**VVFQK**TVRF** LT*WGV*IKCQSS*CIGRSK*GR*IFWFFRENRL TGQ*SS*GFNM*K*KSSLQISRE*Y*RQNIWEN LSEEGKPPQLKPCN*KSNYRSICY*ATDNTRAS PHK*IKA*KETYIRPSS*GFYQESRFGSSKDS*N DKSGN*PNGAEWSSDEYY**WS*E*NKR*FYSE *EKS*PNRITRKRICFQNES*TYKQQYKQYGTR IKYPQFKST*KE*AEEEVFYQAYSCA*TSSQ*KS KPT*LY*IAN**LF*Q*RDKEKKVQPNASQAQQ KPTTHGR*RTCNWSQEE*QAK*TDK*KT*QRYF PRAEVNKCTWFFY*VFKYQ*T*RICQS*PSKRRK RRETRNS*SV**C*RPQRSHVKWRKGFAN*KIC RE*QYFIGTWY*LWHSGKYLVTGS*HSREGKNR TK*MCESVCSI*KPQGTNSWLFQR**K*HRRL*V SIGT*S*PQSGNKHRNGRK*T*CSVFAEYIQGF KAPVICSVFKSRKCRRGMCNILCPLWVLKETKS KSHF*M*TKGRKSRKE*V*YQACTDS*YHCRLSC GWSER*AS**CQM*YQRRL*VLSIISVQRQRNW THYSK*TWTFTKPISYTTTFSHQVIC*N*M*EK SARGKL*GTFNVT*KRNGK*EHSKYSEHN*P**H *RKCF*RSQLKQY**SRFQY**SGLQY**NRFQ **KHSSRTR*KQRAKIECYA*IRGFAT*GL*TK SSWK*L*AS*NKKARI*RSSSDC*YRFLSISDFR *LRTAYGK*SCISGLF*DT**PVR*W*NKGRY* FC*K*H*GKFCCF*QKRPERRA*QES*PFHPYT FGSGLPKRGQEIRVLRRELI**G*RASLLPTLVI W*SKQYTFSVY*A*HRCYRVSV*EHRGEFIIIE E*LK*LQ*PGNIGKGISGTSP**GNKMFC*LVF FTVQ*IGRLDCKYKHPGSFLDWFFQTNEASV*KP GSWSE*QGIGFR**RKRNGLGRK*SRRAKHGFK LR*SSIWV*E*NKRL*RLLRAILSE*HFNHSAE GYHAT*PDKAPAGNG*TRSCVRTAWEPAF*QLPF HHK*LFCP*GPAKSRTKHIRKSSINFTEK**IP YKPESRRPFC*QV*GVCR*FYQ*K*RTRSGKVI PF*MPIIR**VVHAQLLWESSE*KLPISRGAH*G C*CGGATAGRVWATRFDGNILLAKARSRGNPLP GIWNQPLL**P*I*SF*RQSPRVSSCWQHTIFN LCIESSPIESCRICPESSCCSYY*YCWV*CNGRK CEQGEARIDSFNRKGQQKNVHGGVWPDPRRIYA RVQVCQKTPHHFN*SNY*RDYSCCYENRC*VCV *TDTEIFSRNCGRKMGS*LFLGDPVY*RKKNAE* A*F*SQRRCGQWKKPPRSKASKRIPGQKDLQGA RNLLLWALHQHAHRSTGMDGTAVWCFCGEGAFI IHPWHRCPPNCGCAARCLDRGQWLPCNWADV*GT CGDPRVGVGQCSTLPVPGAGHLPDTPDPPQPLL TAASHRYRATGPQE*AYKVAFPGPGSSSHSSVL LLSWLLNILCTSA*KGLLAMQGSLKDFLLEVSLG NLP*AQNYGNFSPEKILKPFKRHQLSKMLIHYL SALFFLFRLLLA*GWKHRVAWPQENSWFP*VYF SKTLCSQRQRVRPFNGRRVLGIDYVT*SQNSPWA VLKCWSGTLGRKF*GRY*K*KGNLKPGHGGSRL *SQHFGRPRWADHWRSGVRNQPGQHGETPSLLK IQKLAGHGGGHL*SQLLRWLRQENHFSPGGGGCS EPRSYHGTPAWVTVRLWLKKKKKKRKMKLEEIS KSLRYIC*ISKECVLKQQKIFKNRFPKTVF*FL ISNK*NVYCCSSGI*SIPLKI*DLWHEYFISIK* QIPPGRKLLLSLR*FFSFAPCC*NHTAS*IILL AEGRKSVFHKPIIQDCL*LLEGLGLP*PPQCAR AVKT*LYKIRFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL SNLGTVRTLRTKQRIQPQKTSVYIELAACEFSE TDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGS SVSNLHVEPCGTNTHASSLQHENSSLLLTKDRM NVEKAEFCNKSKQPGLARSQHNRWAGSKETCND RRTPSTEKKVDLNADPLCERKEWNKQKLPCSENP RDTEDVPWITLNSSIQKVNEWFSRSDELLGSDD SHDGESESNAKVADVLDVLNEVDEYSGSSEKID LLASDPHEALICKSERVHSKSVESNIEDKIFGKT YRKKASLPNLSHVTENLIIGAFVTEPQIIQERP LTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPE MINQGTNQTEQNGQVMNITNSGHENKTKGDSIQN EKNPNPIESLEKESAFKTKAEPISSSISNMELE LNIHNSKAPKKNRLRRKSSTRHIHALELVVSRN LSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSR NLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTF PELKLTNAPGSFTKCSNTSELKEFVNPSLPREE KEEKLETVKVSNNAEDPKDLMLSGERVLQTERSV ESSSISLVPGTDYGTQESISLLEVSTLGKAKTE PNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFK YPLGHEVNHSRETSIEMEESELDAQYLQNTFKVS KRQSFAPFSNPGNAEEECATFSAHSGSLKKQSP KVTFECEQKEENQGKNESNIKPVQTVNITAGFP VVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETG LITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKN LLEENFEEHSMSPEREMGNENIPSTVSTISRNN IRENVFKEASSSNINEVGSSTNEVGSSINEIGSS DENIQAELGRNRGPKLNAMLRLGVLQPEVYKQS LPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLIS DNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTS FAENDIKESSAVFSKSVQKGELSRSPSPFTHTH LAQGYRRGAKKLESSEENLSSEDEELPCFQHLL FGKVNNIPSQSTRHSTVATECLSKNTEENLLSLK NSLNDCSNQVILAKASQEHHLSEETKCSASLFS SQCSELEDLTANTNTQDPFLIGSSKQMRHQSES QGVGLSDKELVSDDEERGTGLEENNQEEQSMDSN LGEAASGCESETSVSEDCSGLSSQSDILTTQQR DTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYP SIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYP ISQNPEGLSADKFEVSADSSTSKNKEPGVERSS PSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIK VVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYL ESGISLFSDDPESDPSEDRAPESARVGNIPSST SALKVPQLKVAESAQSPAAAHTTDTAGYNAMEE SVSREKPELTASTERVNKRMSMVVSGLTPEEFML VYKFARKHHITLTNLITEETTHVVMKTDAEFVC ERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLN EHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGL EICCYGPFTNMPTDQLEWMVQLCGASVVKELSS FTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEA PVVTREWVLDSVALYQCQELDTYLIPQIPHSHY* LQPATGTEPQDPKNELTKWPFQALGAPLTLQSF YCPGY*IFYVHQPEKDFWLCKGPLKIFCLKSPL EICHEHKIMVIFHLRRF*NHLNATN*ARC*FIIY QPYSFYSGCCWLRAGSTEWLGLKRIAGFPKFTS LKPCVHKGRESDPSMEGECLGSIM*LKVRIVLG QFSNVGVEHWGGNSEAGIRNEKET*NLGMVAHAC NPSTLGGQGGQITGGQEFETSLANMVKPHLY*K YRN*PVMVVDTCNPSYSGG*GRRITSAREVEVA VSQDHTTALQPG*Q*DCGSKKKKKKGK*N*KRFL KV*DIFARFLKNVF*NSRRFSRTGFQRQSSNSS LVISKMFIVVALVYNPFLLKYKTSGMNISYL*N DRSHQEGSCCFL*GDFFPLLPVAETIQLHK*FCL LKEEKVFFINPLSRTVYSCWKD*VFPSPPSVQG Q*RLDCTKYVL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA TARRELAETSWTGDRLWGFSDNWAPALRRPSPS ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS* SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS LTLEL*EL*GQSSGYNLKRRLSTLNWLLVNFLR RM*QILNIINPVIMI*TPLRSVQLRGIQKSIRV VLFQTCMWSHVAQILMPAHYSMRTAVYYSLKTE* M*KRLNSVIKANSLA*QGANITDGLEVRKHVMI GGLPAQKKR*I*MLIPCVREKNGISRNCHAQRI LEILKMFLG*H*IAAFRKLMSGFPEVMNC*VLMT HMMGSLNQMPK*LMYWTF*MR*MNILVLQRK*T YWPVILMRL*YVKVKEFTPNQ*RVILKTKYLGK PIGRRQASPT*AM*LKI*L*EHLLLSHR*YKSVP SQIN*SVKGDLHQAFILRILSRKQIWQFKRLLK **IRELTKRSRMVK**ILLIVVMRIKQKVILFR MRKILTQ*NHSKKNLLSKRKLNL*AAV*AIWNSN *ISTIQKHLKRIG*GGSLLPGIFMRLN**SVEI *AHLIVLNCKLIVVLAVKR*RKKSTTKCQSGTA ETYNSWKVKNLQLEPRRVTSQMNRQVKDMTAILS QS*S*QMHLVLLLSVQIPVNLKNLSILAFQEKK KKRN*KQLKCLIMLKTPKISC*VEKGFCKLKDL *RVAVFHWYLVLIMALRKVSRYWKLAL*GRQKQN QINV*VSVQHLKTPRD*FMVVPKIIEMTQKALS IHWDMKLTTVGKQA*KWKKVNLMLSICRIHSRF QSASHLLRFQIQEMQKRNVQHSLPTLGP*RNKVQ KSLLNVNKRKKIKERMSLISSLYRQLISLQAFL WLVRKISQLIMPNVVSKEALGFVYHLSSEATKL DSLLQINMDFYKTHIVYHHFFPSSHLLKLNVRKI C*RKTLRNIQCHLKEKWEMRTFQVQ*AQLAVIT LEKMFLKKPAQAILMK*VPVLMKWAPVLMK*VP VMKTFKQN*VETEGQN*MLCLD*GFCNLRSINKV FLEVIVSILK*KSKNMKK*FRLLIQISLHI*FQ IT*NSLWEVVMHLRFVLRHLMTC*MMVK*RKIL VLLKMTLRKVLLFLAKASRKESLAGVLALSPIHI WLRVTEEGPRN*SPQKRTYLVRMKSFPASNTCY LVK*TIYLLSLLGIAPLLPSVCLRTQRRIYYH* RIA*MTAVTR*YWQRHLRNITLVRKQNVLLACFL HSAVNWKT*LQIQTPRILS*LVLPNK*GISLKA RELV*VTRNWFQMMKKEERAWKKIIKKSKAWIQ T*VKQHLGVRVKQASLKTAQGYPLRVTF*PLSRG IPCNIT**SSSRKWLN*KLC*NSMGASLLTATL PS*VTLLPLRTCEIQNKAHQKKQY*LHRKVVNT L*ARIQKAFLLTSLRCLQIVLPVKIKNQEWKGHP LLNAHH*MIGGTCTVALGVFRIETTHLKRSSLR LLMWRSNSWKSLGHTI*RKHLTCQGKI*REPLT WNLESASSLMTLNLILLKTEPQSQLVLATYHLQP LH*KFPN*KLQNLPRVQLLLILLILLGIMQWKK V*AGRSQN*QLQQKGSTKECPWWCLA*PQKNLC SCTSLPENTTSL*LI*LLKRLLMLL*KQMLSLCV NGH*NIF*ELREENG*LAISG*PSLLKKEKC*M SMILKSEEMWSMEETTKVQSEQENPRTERSSGG *KSVAMGPSPTCPQINWNGWYSCVVLLW*RSFHH SPLAQVSTQLWLCSQMPGQRTMASMQLGRCVRH LW*PESGCWTV*HSTSARSWTPT*YPRSPTATT DCSQPQVQSHRTPRMSLQSGLSRPWELLSLFSPS TVLATKYFMYISLKRTSGYARVP*RFSA*SLPW KSAMSTKLW*FFT*EDFKTI*TPPIEQDADSLF ISPILSIQAVVGLGLEAQSGLASRE*LVSLSLLL *NPVFTKAESQTLQWKESAWDRLCDLKSE*SLG SSQMLEWNIGEEILRQVLEMKRKLETWAWWLTP VIPALWEAKVGRSLEVRSSKPAWPTW*NPISTKN TEISRSWWWTPVIPATQVAKAGESLQPGRWRLQ *AKIIPRHSSLGDSETVAQKKKKKKENETRRDF *KSEIYLLDF*RMCSKTAEDFQEPVSKDSLLIPH ***VKCLLL*LWYIIHSS*NIRPLA*IFHIYKM TDPTRKEAVAFFEVIFFLCSLLLKPYSFINNFA C*RKKKCFS*THYPGLFIAVGRTRSSLAPPVCKG SEDLIVQNTFCKCCAVNTANKLGSKHF