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Sequences

Sequence BRCA1.mAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC TCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGATCTGATTCTTCTGAAGATA CCGTTAATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAAA GGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGGGAT ACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTTCCA TCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCCTAT AAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTCATCCCCT TCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTG TTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGA ATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACCTCT GCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAAGTG TGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCTCGT GTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAA CGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGC ATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGA AATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTC ACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCACCTG TGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGACT GCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTAC TGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAA TCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCA GCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTA AAACCCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGT TCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAA TCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAC AGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGA GCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATTTCTAAA AGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTA GTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACA GATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCT GAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAG TGAAGACTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Single exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT L*PWNCENSEDKAADTTSKDVCLH*IGI*FF*RY R**GNLLQCGRSRIVTNHPSRNQG*NQFGFCKK G*SSIWV*E*NKRL*RLLRAILSE*HFNHSAEG YHAT*PDKAPAGNG*TRSCVRTAWEPAF*QLPFH HK*LFCP*GPAKSRTKHIRKSSINFTEK**IPY KPESRRPFC*QV*GVCR*FYQ*K*RTRSGKVIP F*MPIIR**VVHAQLLWESSE*KLPISRGAH*GC *CGGATAGRVWATRFDGNILLAKARSRGNPLPG IWNQPLL**P*I*SF*RQSPRVSSCWQHTIFNL CIESSPIESCRICPESSCCSYY*YCWV*CNGRKC EQGEARIDSFNRKGQQKNVHGGVWPDPRRIYAR VQVCQKTPHHFN*SNY*RDYSCCYENRC*VCV* TDTEIFSRNCGRKMGS*LFLGDPVY*RKKNAE*A *F*SQRRCGQWKKPPRSKASKRIPGQKDLQGAR NLLLWALHQHAHRSTGMDGTAVWCFCGEGAFII HPWHRCPPNCGCAARCLDRGQWLPCNWADV*GTC GDPRVGVGQCSTLPVPGAGHLPDTPDPPQPLLT AASHRYRATGPQE*AYKVAFPGPGSSSHSSVLL LSWLLNILCTSA*KGLLAMQGSLKDFLLEVSLGN LP*AQNYGNFSPEKILKPFKRHQLSKMLIHYLS ALFFLFRLLLA*GWKHRVAWPQENSWFP*VYFS KTLCSQRQRVRPFNGRRVLGIDYVT*SQNSPWAV LKCWSGTLGRKF*GRY*K*KGNLKPGHGGSRL* SQHFGRPRWADHWRSGVRNQPGQHGETPSLLKI QKLAGHGGGHL*SQLLRWLRQENHFSPGGGGCSE PRSYHGTPAWVTVRLWLKKKKKKRKMKLEEISK SLRYIC*ISKECVLKQQKIFKNRFPKTVF*FLI SNK*NVYCCSSGI*SIPLKI*DLWHEYFISIK*Q IPPGRKLLLSLR*FFSFAPCC*NHTAS*IILLA EGRKSVFHKPIIQDCL*LLEGLGLP*PPQCARA VKT*LYKIRFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL SNLGTVRTLRTKQRIQPQKTSVYIELGSDSSED TVNKATYCSVGDQELLQITPQGTRDEISLDSAKK GEAASGCESETSVSEDCSGLSSQSDILTTQQRD TMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPS IISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPI SQNPEGLSADKFEVSADSSTSKNKEPGVERSSP SKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKV VDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLE SGISLFSDDPESDPSEDRAPESARVGNIPSSTS ALKVPQLKVAESAQSPAAAHTTDTAGYNAMEES VSREKPELTASTERVNKRMSMVVSGLTPEEFMLV YKFARKHHITLTNLITEETTHVVMKTDAEFVCE RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNE HDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLE ICCYGPFTNMPTDQLEWMVQLCGASVVKELSSF TLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAP VVTREWVLDSVALYQCQELDTYLIPQIPHSHY*L QPATGTEPQDPKNELTKWPFQALGAPLTLQSFY CPGY*IFYVHQPEKDFWLCKGPLKIFCLKSPLE ICHEHKIMVIFHLRRF*NHLNATN*ARC*FIIYQ PYSFYSGCCWLRAGSTEWLGLKRIAGFPKFTSL KPCVHKGRESDPSMEGECLGSIM*LKVRIVLGQ FSNVGVEHWGGNSEAGIRNEKET*NLGMVAHACN PSTLGGQGGQITGGQEFETSLANMVKPHLY*KY RN*PVMVVDTCNPSYSGG*GRRITSAREVEVAV SQDHTTALQPG*Q*DCGSKKKKKKGK*N*KRFLK V*DIFARFLKNVF*NSRRFSRTGFQRQSSNSSL VISKMFIVVALVYNPFLLKYKTSGMNISYL*ND RSHQEGSCCFL*GDFFPLLPVAETIQLHK*FCLL KEEKVFFINPLSRTVYSCWKD*VFPSPPSVQGQ *RLDCTKYVL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA TARRELAETSWTGDRLWGFSDNWAPALRRPSPS ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS* SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS LTLEL*EL*GQSSGYNLKRRLSTLNWDLILLKI PLIRQLIAVWEIKNCYKSPLKEPGMKSVWILQK RVKQHLGVRVKQASLKTAQGYPLRVTF*PLSRGI PCNIT**SSSRKWLN*KLC*NSMGASLLTATLP S*VTLLPLRTCEIQNKAHQKKQY*LHRKVVNTL *ARIQKAFLLTSLRCLQIVLPVKIKNQEWKGHPL LNAHH*MIGGTCTVALGVFRIETTHLKRSSLRL LMWRSNSWKSLGHTI*RKHLTCQGKI*REPLTW NLESASSLMTLNLILLKTEPQSQLVLATYHLQPL H*KFPN*KLQNLPRVQLLLILLILLGIMQWKKV *AGRSQN*QLQQKGSTKECPWWCLA*PQKNLCS CTSLPENTTSL*LI*LLKRLLMLL*KQMLSLCVN GH*NIF*ELREENG*LAISG*PSLLKKEKC*MS MILKSEEMWSMEETTKVQSEQENPRTERSSGG* KSVAMGPSPTCPQINWNGWYSCVVLLW*RSFHHS PLAQVSTQLWLCSQMPGQRTMASMQLGRCVRHL W*PESGCWTV*HSTSARSWTPT*YPRSPTATTD CSQPQVQSHRTPRMSLQSGLSRPWELLSLFSPST VLATKYFMYISLKRTSGYARVP*RFSA*SLPWK SAMSTKLW*FFT*EDFKTI*TPPIEQDADSLFI SPILSIQAVVGLGLEAQSGLASRE*LVSLSLLL* NPVFTKAESQTLQWKESAWDRLCDLKSE*SLGS SQMLEWNIGEEILRQVLEMKRKLETWAWWLTPV IPALWEAKVGRSLEVRSSKPAWPTW*NPISTKNT EISRSWWWTPVIPATQVAKAGESLQPGRWRLQ* AKIIPRHSSLGDSETVAQKKKKKKENETRRDF* KSEIYLLDF*RMCSKTAEDFQEPVSKDSLLIPH* **VKCLLL*LWYIIHSS*NIRPLA*IFHIYKMT DPTRKEAVAFFEVIFFLCSLLLKPYSFINNFAC *RKKKCFS*THYPGLFIAVGRTRSSLAPPVCKGS EDLIVQNTFCKCCAVNTANKLGSKHF

Sequence BRCA1.qAug05

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Single exon skipping

Frame 0

Frame 1

Frame 2

Sequence BRCA1.oAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT GCTCTGGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGAGTGTCC CATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAAGGGCCT TCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCATTTGTG CTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTCTATCAT CCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTCTCTAAC CTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGATCTGATTCTTCTGAAGATACCGTTA ATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAAAGGCTGC TTGTGAATTTTCTGAGACGGATGTAACAAATACTGAACATCATCAACCCAGTAATAATGATTTGAACACCACTGAGAAGCGTGCAGCTGAGAGGCATCCA GAAAAGTATCAGGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTC AGCAGAGGGATACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAG CTACCCTTCCATCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGTATTAACTTCACAGAAAAGTAGTGAA TACCCTATAAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGT CATCCCCTTCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCAT TAAGGTTGTTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCT TACCTGGAATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTT CAACCTCTGCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGA AGAAAGTGTGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTT ATGCTCGTGTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTG TGTGTGAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCT GAATGAGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGG GGGCTAGAAATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGC TTCCATGCAATTGGGCAGATGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACC TGATACCCCAGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGC CCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCC TTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCA CCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAA GAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATT ATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAA CTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGC CAACATGGTGAAACCCCATCTCTACTAAAAATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGA ATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAA AAAAAGGAAAATGAAACTAGAAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAAC CGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACC TCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTG AAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTA GGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGG TAGCAAACACTTCCA

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Single exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL LWFIGTERNGFICSSR*RSTKCH*CYAENLRVS HLSGVDQGTCLHKV*PHILQILHAETSQPEERA FTVSFM*E*YNQKEPTRKYEI*STC*RAIENHLC FSA*HRFGVCKQL*FCKKGK*LS*TSKR*SFYH PKYGLQKPCQKTSTE*TRKSFLAGNQSQCPTL* PWNCENSEDKAADTTSKDVCLH*IGI*FF*RYR* *GNLLQCGRSRIVTNHPSRNQG*NQFGFCKKGC L*IF*DGCNKY*TSSTQ***FEHH*EACS*EAS RKVSG*SSIWV*E*NKRL*RLLRAILSE*HFNHS AEGYHAT*PDKAPAGNG*TRSCVRTAWEPAF*Q LPFHHK*LFCP*GPAKSRTKHIRKSINFTEK** IPYKPESRRPFC*QV*GVCR*FYQ*K*RTRSGKV IPF*MPIIR**VVHAQLLWESSE*KLPISRGAH *GC*CGGATAGRVWATRFDGNILLAKARSRGNP LPGIWNQPLL**P*I*SF*RQSPRVSSCWQHTIF NLCIESSPIESCRICPESSCCSYY*YCWV*CNG RKCEQGEARIDSFNRKGQQKNVHGGVWPDPRRI YARVQVCQKTPHHFN*SNY*RDYSCCYENRC*VC V*TDTEIFSRNCGRKMGS*LFLGDPVY*RKKNA E*A*F*SQRRCGQWKKPPRSKASKRIPGQKDLQ GARNLLLWALHQHAHRVSTQLWLCSQMPGQRTMA SMQLGRCVRHLW*PESGCWTV*HSTSARSWTPT *YPRSPTATTDCSQPQVQSHRTPRMSLQSGLSR PWELLSLFSPSTVLATKYFMYISLKRTSGYARVP *RFSA*SLPWKSAMSTKLW*FFT*EDFKTI*TP PIEQDADSLFISPILSIQAVVGLGLEAQSGLAS RE*LVSLSLLL*NPVFTKAESQTLQWKESAWDRL CDLKSE*SLGSSQMLEWNIGEEILRQVLEMKRK LETWAWWLTPVIPALWEAKVGRSLEVRSSKPAW PTW*NPISTKNTEISRSWWWTPVIPATQVAKAGE SLQPGRWRLQ*AKIIPRHSSLGDSETVAQKKKK KKENETRRDF*KSEIYLLDF*RMCSKTAEDFQE PVSKDSLLIPH***VKCLLL*LWYIIHSS*NIRP LA*IFHIYKMTDPTRKEAVAFFEVIFFLCSLLL KPYSFINNFAC*RKKKCFS*THYPGLFIAVGRT RSSLAPPVCKGSEDLIVQNTFCKCCAVNTANKLG SKHF

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL CSGSLEQKEMDLSALRVEEVQNVINAMQKILECP ICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGP SQCPLCKNDITKRSLQESTRFSQLVEELLKIIC AFQLDTGLEYANSYNFAKKENNSPEHLKDEVSII QSMGYRNRAKRLLQSEPENPSLQETSLSVQLSN LGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTV NKATYCSVGDQELLQITPQGTRDEISLDSAKKAA CEFSETDVTNTEHHQPSNNDLNTTEKRAAERHP EKYQGEAASGCESETSVSEDCSGLSSQSDILTT QQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNS YPSIISDSSALEDLRNPEQSTSEKVLTSQKSSE YPISQNPEGLSADKFEVSADSSTSKNKEPGVER SSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELI KVVDVEEQQLEESGPHDLTETSYLPRQDLEGTP YLESGISLFSDDPESDPSEDRAPESARVGNIPS STSALKVPQLKVAESAQSPAAAHTTDTAGYNAME ESVSREKPELTASTERVNKRMSMVVSGLTPEEF MLVYKFARKHHITLTNLITEETTHVVMKTDAEF VCERTLKYFLGIAGGKWVVSYFWVTQSIKERKML NEHDFEVRGDVVNGRNHQGPKRARESQDRKIFR GLEICCYGPFTNMPTGCPPNCGCAARCLDRGQW LPCNWADV*GTCGDPRVGVGQCSTLPVPGAGHLP DTPDPPQPLLTAASHRYRATGPQE*AYKVAFPG PGSSSHSSVLLLSWLLNILCTSA*KGLLAMQGS LKDFLLEVSLGNLP*AQNYGNFSPEKILKPFKRH QLSKMLIHYLSALFFLFRLLLA*GWKHRVAWPQ ENSWFP*VYFSKTLCSQRQRVRPFNGRRVLGID YVT*SQNSPWAVLKCWSGTLGRKF*GRY*K*KGN LKPGHGGSRL*SQHFGRPRWADHWRSGVRNQPG QHGETPSLLKIQKLAGHGGGHL*SQLLRWLRQE NHFSPGGGGCSEPRSYHGTPAWVTVRLWLKKKKK KRKMKLEEISKSLRYIC*ISKECVLKQQKIFKN RFPKTVF*FLISNK*NVYCCSSGI*SIPLKI*D LWHEYFISIK*QIPPGRKLLLSLR*FFSFAPCC* NHTAS*IILLAEGRKSVFHKPIIQDCL*LLEGL GLP*PPQCARAVKT*LYKIRFVNVVLLTLQINL VANTS

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA TARRELAETSWTGDRLWGFSDNWAPALRRPSPS ALVHWNRKKWIYLLFALKKYKMSLMLCRKS*SV PSVWS*SRNLSPQSVTTYFANFAC*NFSTRRKGL HSVLYVRMI*PKGAYKKVRDLVNLLKSY*KSFV LFSLTQVWSMQTAIILQKRKITLLNI*KMKFLS SKVWATETVPKDFYRVNPKILPCRKPVSVSNSLT LEL*EL*GQSSGYNLKRRLSTLNWDLILLKIPL IRQLIAVWEIKNCYKSPLKEPGMKSVWILQKRL LVNFLRRM*QILNIINPVIMI*TPLRSVQLRGIQ KSIRVKQHLGVRVKQASLKTAQGYPLRVTF*PL SRGIPCNIT**SSSRKWLN*KLC*NSMGASLLT ATLPS*VTLLPLRTCEIQNKAHQKKY*LHRKVVN TL*ARIQKAFLLTSLRCLQIVLPVKIKNQEWKG HPLLNAHH*MIGGTCTVALGVFRIETTHLKRSS LRLLMWRSNSWKSLGHTI*RKHLTCQGKI*REPL TWNLESASSLMTLNLILLKTEPQSQLVLATYHL QPLH*KFPN*KLQNLPRVQLLLILLILLGIMQW KKV*AGRSQN*QLQQKGSTKECPWWCLA*PQKNL CSCTSLPENTTSL*LI*LLKRLLMLL*KQMLSL CVNGH*NIF*ELREENG*LAISG*PSLLKKEKC *MSMILKSEEMWSMEETTKVQSEQENPRTERSSG G*KSVAMGPSPTCPQGVHPIVVVQPDAWTEDNG FHAIGQMCEAPVVTREWVLDSVALYQCQELDTY LIPQIPHSHY*LQPATGTEPQDPKNELTKWPFQA LGAPLTLQSFYCPGY*IFYVHQPEKDFWLCKGP LKIFCLKSPLEICHEHKIMVIFHLRRF*NHLNA TN*ARC*FIIYQPYSFYSGCCWLRAGSTEWLGLK RIAGFPKFTSLKPCVHKGRESDPSMEGECLGSI M*LKVRIVLGQFSNVGVEHWGGNSEAGIRNEKE T*NLGMVAHACNPSTLGGQGGQITGGQEFETSLA NMVKPHLY*KYRN*PVMVVDTCNPSYSGG*GRR ITSAREVEVAVSQDHTTALQPG*Q*DCGSKKKK KKGK*N*KRFLKV*DIFARFLKNVF*NSRRFSRT GFQRQSSNSSLVISKMFIVVALVYNPFLLKYKT SGMNISYL*NDRSHQEGSCCFL*GDFFPLLPVA ETIQLHK*FCLLKEEKVFFINPLSRTVYSCWKD* VFPSPPSVQGQ*RLDCTKYVL*MLCC*HCK*TW *QTLP

Sequence BRCA1.lAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC TCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGATCTGATTCTTCTGAAGATA CCGTTAATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAAA GGCTGCTTGTGAATTTTCTGAGACGGATGTAACAAATACTGAACATCATCAACCCAGTAATAATGATTTGAACACCACTGAGAAGCGTGCAGCTGAGAGG CATCCAGAAAAGTATCAGGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAA CCACTCAGCAGAGGGATACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTC TAACAGCTACCCTTCCATCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGTATTAACTTCACAGAAAAGT AGTGAATACCCTATAAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGG AAAGGTCATCCCCTTCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGA GCTCATTAAGGTTGTTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGA ACCCCTTACCTGGAATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATAC CATCTTCAACCTCTGCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGC AATGGAAGAAAGTGTGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAA GAATTTATGCTCGTGTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTG AGTTTGTGTGTGAACGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAA AATGCTGAATGAGCATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATC TTCAGGGGGCTAGAAATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGG AGCTTTCATCATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGAT GTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCAC AGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTC TTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAA GTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGA TTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTA AGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAAT AGTCCTTGGGCAGTTCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTG GCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATC TCTACTAAAAATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGT GGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAG AAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTT CTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATA TCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAA TAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCA GTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA

BRCA1-F2 (forward primer)
BRCA1-R2 (reverse primer)
Single exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT L*PWNCENSEDKAADTTSKDVCLH*IGI*FF*RY R**GNLLQCGRSRIVTNHPSRNQG*NQFGFCKK GCL*IF*DGCNKY*TSSTQ***FEHH*EACS*E ASRKVSG*SSIWV*E*NKRL*RLLRAILSE*HFN HSAEGYHAT*PDKAPAGNG*TRSCVRTAWEPAF *QLPFHHK*LFCP*GPAKSRTKHIRKSINFTEK **IPYKPESRRPFC*QV*GVCR*FYQ*K*RTRSG KVIPF*MPIIR**VVHAQLLWESSE*KLPISRG AH*GC*CGGATAGRVWATRFDGNILLAKARSRG NPLPGIWNQPLL**P*I*SF*RQSPRVSSCWQHT IFNLCIESSPIESCRICPESSCCSYY*YCWV*C NGRKCEQGEARIDSFNRKGQQKNVHGGVWPDPR RIYARVQVCQKTPHHFN*SNY*RDYSCCYENRC* VCV*TDTEIFSRNCGRKMGS*LFLGDPVY*RKK NAE*A*F*SQRRCGQWKKPPRSKASKRIPGQKD LQGARNLLLWALHQHAHRSTGMDGTAVWCFCGEG AFIIHPWHRCPPNCGCAARCLDRGQWLPCNWAD V*GTCGDPRVGVGQCSTLPVPGAGHLPDTPDPP QPLLTAASHRYRATGPQE*AYKVAFPGPGSSSHS SVLLLSWLLNILCTSA*KGLLAMQGSLKDFLLE VSLGNLP*AQNYGNFSPEKILKPFKRHQLSKML IHYLSALFFLFRLLLA*GWKHRVAWPQENSWFP* VYFSKTLCSQRQRVRPFNGRRVLGIDYVT*SQN SPWAVLKCWSGTLGRKF*GRY*K*KGNLKPGHG GSRL*SQHFGRPRWADHWRSGVRNQPGQHGETPS LLKIQKLAGHGGGHL*SQLLRWLRQENHFSPGG GGCSEPRSYHGTPAWVTVRLWLKKKKKKRKMKL EEISKSLRYIC*ISKECVLKQQKIFKNRFPKTVF *FLISNK*NVYCCSSGI*SIPLKI*DLWHEYFI SIK*QIPPGRKLLLSLR*FFSFAPCC*NHTAS* IILLAEGRKSVFHKPIIQDCL*LLEGLGLP*PPQ CARAVKT*LYKIRFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL SNLGTVRTLRTKQRIQPQKTSVYIELGSDSSED TVNKATYCSVGDQELLQITPQGTRDEISLDSAKK AACEFSETDVTNTEHHQPSNNDLNTTEKRAAER HPEKYQGEAASGCESETSVSEDCSGLSSQSDIL TTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPS NSYPSIISDSSALEDLRNPEQSTSEKVLTSQKS SEYPISQNPEGLSADKFEVSADSSTSKNKEPGV ERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEE LIKVVDVEEQQLEESGPHDLTETSYLPRQDLEG TPYLESGISLFSDDPESDPSEDRAPESARVGNI PSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNA MEESVSREKPELTASTERVNKRMSMVVSGLTPE EFMLVYKFARKHHITLTNLITEETTHVVMKTDA EFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERK MLNEHDFEVRGDVVNGRNHQGPKRARESQDRKI FRGLEICCYGPFTNMPTDQLEWMVQLCGASVVK ELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQM CEAPVVTREWVLDSVALYQCQELDTYLIPQIPH SHY*LQPATGTEPQDPKNELTKWPFQALGAPLT LQSFYCPGY*IFYVHQPEKDFWLCKGPLKIFCLK SPLEICHEHKIMVIFHLRRF*NHLNATN*ARC* FIIYQPYSFYSGCCWLRAGSTEWLGLKRIAGFP KFTSLKPCVHKGRESDPSMEGECLGSIM*LKVRI VLGQFSNVGVEHWGGNSEAGIRNEKET*NLGMV AHACNPSTLGGQGGQITGGQEFETSLANMVKPH LY*KYRN*PVMVVDTCNPSYSGG*GRRITSAREV EVAVSQDHTTALQPG*Q*DCGSKKKKKKGK*N* KRFLKV*DIFARFLKNVF*NSRRFSRTGFQRQS SNSSLVISKMFIVVALVYNPFLLKYKTSGMNISY L*NDRSHQEGSCCFL*GDFFPLLPVAETIQLHK *FCLLKEEKVFFINPLSRTVYSCWKD*VFPSPP SVQGQ*RLDCTKYVL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA TARRELAETSWTGDRLWGFSDNWAPALRRPSPS ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS* SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS LTLEL*EL*GQSSGYNLKRRLSTLNWDLILLKI PLIRQLIAVWEIKNCYKSPLKEPGMKSVWILQK RLLVNFLRRM*QILNIINPVIMI*TPLRSVQLRG IQKSIRVKQHLGVRVKQASLKTAQGYPLRVTF* PLSRGIPCNIT**SSSRKWLN*KLC*NSMGASL LTATLPS*VTLLPLRTCEIQNKAHQKKY*LHRKV VNTL*ARIQKAFLLTSLRCLQIVLPVKIKNQEW KGHPLLNAHH*MIGGTCTVALGVFRIETTHLKR SSLRLLMWRSNSWKSLGHTI*RKHLTCQGKI*RE PLTWNLESASSLMTLNLILLKTEPQSQLVLATY HLQPLH*KFPN*KLQNLPRVQLLLILLILLGIM QWKKV*AGRSQN*QLQQKGSTKECPWWCLA*PQK NLCSCTSLPENTTSL*LI*LLKRLLMLL*KQML SLCVNGH*NIF*ELREENG*LAISG*PSLLKKE KC*MSMILKSEEMWSMEETTKVQSEQENPRTERS SGG*KSVAMGPSPTCPQINWNGWYSCVVLLW*R SFHHSPLAQVSTQLWLCSQMPGQRTMASMQLGR CVRHLW*PESGCWTV*HSTSARSWTPT*YPRSPT ATTDCSQPQVQSHRTPRMSLQSGLSRPWELLSL FSPSTVLATKYFMYISLKRTSGYARVP*RFSA* SLPWKSAMSTKLW*FFT*EDFKTI*TPPIEQDAD SLFISPILSIQAVVGLGLEAQSGLASRE*LVSL SLLL*NPVFTKAESQTLQWKESAWDRLCDLKSE *SLGSSQMLEWNIGEEILRQVLEMKRKLETWAWW LTPVIPALWEAKVGRSLEVRSSKPAWPTW*NPI STKNTEISRSWWWTPVIPATQVAKAGESLQPGR WRLQ*AKIIPRHSSLGDSETVAQKKKKKKENETR RDF*KSEIYLLDF*RMCSKTAEDFQEPVSKDSL LIPH***VKCLLL*LWYIIHSS*NIRPLA*IFH IYKMTDPTRKEAVAFFEVIFFLCSLLLKPYSFIN NFAC*RKKKCFS*THYPGLFIAVGRTRSSLAPP VCKGSEDLIVQNTFCKCCAVNTANKLGSKHF