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Sequences

Sequence BRCA1.nAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC
GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT
GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA
GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA
GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA
TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC
TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC
TCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGCTGCTTGTGAATTTTCTGAGA
CGGATGTAACAAATACTGAACATCATCAACCCAGTAATAATGATTTGAACACCACTGAGAAGCGTGCAGCTGAGAGGCATCCAGAAAAGTATCAGGGTGA
AGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGGGATACCATG
CAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTTCCATCATAA
GTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCCTATAAGCCA
GAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTCATCCCCTTCTAAA
TGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTGTTGATG
TGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGAATCTGG
AATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACCTCTGCATTG
AAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAAGTGTGAGCA
GGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCTCGTGTACAA
GTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAACGGACA
CTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGCATGATT
TTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCTG
TTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTCACCCTT
GGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCACCTGTGGTGA
CCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGACTGCAGCC
AGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCT
GGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCC
ATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTA
TTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCC
TGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAA
ATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCAG
CACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAGAAAT
TAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGAGCCAAG
ATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATTTCTAAAAGTCTG
AGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATA
AGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATCCC
ACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGA
AGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGA
CTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA
  • BRCA1-F2 (forward primer)
  • BRCA1-R2 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL
RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL
LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR
VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE
RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH
LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF
YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT
L*PWNCENSEDKAADTTSKDVCLH*IGCL*IF*D
GCNKY*TSSTQ***FEHH*EACS*EASRKVSG*
SSIWV*E*NKRL*RLLRAILSE*HFNHSAEGYH
AT*PDKAPAGNG*TRSCVRTAWEPAF*QLPFHHK
*LFCP*GPAKSRTKHIRKSSINFTEK**IPYKP
ESRRPFC*QV*GVCR*FYQ*K*RTRSGKVIPF*
MPIIR**VVHAQLLWESSE*KLPISRGAH*GC*C
GGATAGRVWATRFDGNILLAKARSRGNPLPGIW
NQPLL**P*I*SF*RQSPRVSSCWQHTIFNLCI
ESSPIESCRICPESSCCSYY*YCWV*CNGRKCEQ
GEARIDSFNRKGQQKNVHGGVWPDPRRIYARVQ
VCQKTPHHFN*SNY*RDYSCCYENRC*VCV*TD
TEIFSRNCGRKMGS*LFLGDPVY*RKKNAE*A*F
*SQRRCGQWKKPPRSKASKRIPGQKDLQGARNL
LLWALHQHAHRSTGMDGTAVWCFCGEGAFIIHP
WHRCPPNCGCAARCLDRGQWLPCNWADV*GTCGD
PRVGVGQCSTLPVPGAGHLPDTPDPPQPLLTAA
SHRYRATGPQE*AYKVAFPGPGSSSHSSVLLLS
WLLNILCTSA*KGLLAMQGSLKDFLLEVSLGNLP
*AQNYGNFSPEKILKPFKRHQLSKMLIHYLSAL
FFLFRLLLA*GWKHRVAWPQENSWFP*VYFSKT
LCSQRQRVRPFNGRRVLGIDYVT*SQNSPWAVLK
CWSGTLGRKF*GRY*K*KGNLKPGHGGSRL*SQ
HFGRPRWADHWRSGVRNQPGQHGETPSLLKIQK
LAGHGGGHL*SQLLRWLRQENHFSPGGGGCSEPR
SYHGTPAWVTVRLWLKKKKKKRKMKLEEISKSL
RYIC*ISKECVLKQQKIFKNRFPKTVF*FLISN
K*NVYCCSSGI*SIPLKI*DLWHEYFISIK*QIP
PGRKLLLSLR*FFSFAPCC*NHTAS*IILLAEG
RKSVFHKPIIQDCL*LLEGLGLP*PPQCARAVK
T*LYKIRFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC
DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL
CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE
CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK
GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI
ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS
IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL
SNLGTVRTLRTKQRIQPQKTSVYIELAACEFSE
TDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGE
AASGCESETSVSEDCSGLSSQSDILTTQQRDTM
QHNLIKLQQEMAELEAVLEQHGSQPSNSYPSII
SDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQ
NPEGLSADKFEVSADSSTSKNKEPGVERSSPSK
CPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVD
VEEQQLEESGPHDLTETSYLPRQDLEGTPYLESG
ISLFSDDPESDPSEDRAPESARVGNIPSSTSAL
KVPQLKVAESAQSPAAAHTTDTAGYNAMEESVS
REKPELTASTERVNKRMSMVVSGLTPEEFMLVYK
FARKHHITLTNLITEETTHVVMKTDAEFVCERT
LKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHD
FEVRGDVVNGRNHQGPKRARESQDRKIFRGLEIC
CYGPFTNMPTDQLEWMVQLCGASVVKELSSFTL
GTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVV
TREWVLDSVALYQCQELDTYLIPQIPHSHY*LQP
ATGTEPQDPKNELTKWPFQALGAPLTLQSFYCP
GY*IFYVHQPEKDFWLCKGPLKIFCLKSPLEIC
HEHKIMVIFHLRRF*NHLNATN*ARC*FIIYQPY
SFYSGCCWLRAGSTEWLGLKRIAGFPKFTSLKP
CVHKGRESDPSMEGECLGSIM*LKVRIVLGQFS
NVGVEHWGGNSEAGIRNEKET*NLGMVAHACNPS
TLGGQGGQITGGQEFETSLANMVKPHLY*KYRN
*PVMVVDTCNPSYSGG*GRRITSAREVEVAVSQ
DHTTALQPG*Q*DCGSKKKKKKGK*N*KRFLKV*
DIFARFLKNVF*NSRRFSRTGFQRQSSNSSLVI
SKMFIVVALVYNPFLLKYKTSGMNISYL*NDRS
HQEGSCCFL*GDFFPLLPVAETIQLHK*FCLLKE
EKVFFINPLSRTVYSCWKD*VFPSPPSVQGQ*R
LDCTKYVL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA
TARRELAETSWTGDRLWGFSDNWAPALRRPSPS
ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS*
SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK
GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS
FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF
LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS
LTLEL*EL*GQSSGYNLKRRLSTLNWLLVNFLR
RM*QILNIINPVIMI*TPLRSVQLRGIQKSIRV
KQHLGVRVKQASLKTAQGYPLRVTF*PLSRGIPC
NIT**SSSRKWLN*KLC*NSMGASLLTATLPS*
VTLLPLRTCEIQNKAHQKKQY*LHRKVVNTL*A
RIQKAFLLTSLRCLQIVLPVKIKNQEWKGHPLLN
AHH*MIGGTCTVALGVFRIETTHLKRSSLRLLM
WRSNSWKSLGHTI*RKHLTCQGKI*REPLTWNL
ESASSLMTLNLILLKTEPQSQLVLATYHLQPLH*
KFPN*KLQNLPRVQLLLILLILLGIMQWKKV*A
GRSQN*QLQQKGSTKECPWWCLA*PQKNLCSCT
SLPENTTSL*LI*LLKRLLMLL*KQMLSLCVNGH
*NIF*ELREENG*LAISG*PSLLKKEKC*MSMI
LKSEEMWSMEETTKVQSEQENPRTERSSGG*KS
VAMGPSPTCPQINWNGWYSCVVLLW*RSFHHSPL
AQVSTQLWLCSQMPGQRTMASMQLGRCVRHLW*
PESGCWTV*HSTSARSWTPT*YPRSPTATTDCS
QPQVQSHRTPRMSLQSGLSRPWELLSLFSPSTVL
ATKYFMYISLKRTSGYARVP*RFSA*SLPWKSA
MSTKLW*FFT*EDFKTI*TPPIEQDADSLFISP
ILSIQAVVGLGLEAQSGLASRE*LVSLSLLL*NP
VFTKAESQTLQWKESAWDRLCDLKSE*SLGSSQ
MLEWNIGEEILRQVLEMKRKLETWAWWLTPVIP
ALWEAKVGRSLEVRSSKPAWPTW*NPISTKNTEI
SRSWWWTPVIPATQVAKAGESLQPGRWRLQ*AK
IIPRHSSLGDSETVAQKKKKKKENETRRDF*KS
EIYLLDF*RMCSKTAEDFQEPVSKDSLLIPH***
VKCLLL*LWYIIHSS*NIRPLA*IFHIYKMTDP
TRKEAVAFFEVIFFLCSLLLKPYSFINNFAC*R
KKKCFS*THYPGLFIAVGRTRSSLAPPVCKGSED
LIVQNTFCKCCAVNTANKLGSKHF

Sequence BRCA1.mAug05

GTACCTTGATTTCGTATTCTGAGAGGCTGCTGCTTAGCGGTAGCCCCTTGGTTTCCGTGGCAACGGAAAAGCGCGGGAATTACAGATAAATTAAAACTGC
GACTGCGCGGCGTGAGCTCGCTGAGACTTCCTGGACGGGGGACAGGCTGTGGGGTTTCTCAGATAACTGGGCCCCTGCGCTCAGGAGGCCTTCACCCTCT
GCTCTGGGTAAAGTTCATTGGAACAGAAAGAAATGGATTTATCTGCTCTTCGCGTTGAAGAAGTACAAAATGTCATTAATGCTATGCAGAAAATCTTAGA
GTGTCCCATCTGTCTGGAGTTGATCAAGGAACCTGTCTCCACAAAGTGTGACCACATATTTTGCAAATTTTGCATGCTGAAACTTCTCAACCAGAAGAAA
GGGCCTTCACAGTGTCCTTTATGTAAGAATGATATAACCAAAAGGAGCCTACAAGAAAGTACGAGATTTAGTCAACTTGTTGAAGAGCTATTGAAAATCA
TTTGTGCTTTTCAGCTTGACACAGGTTTGGAGTATGCAAACAGCTATAATTTTGCAAAAAAGGAAAATAACTCTCCTGAACATCTAAAAGATGAAGTTTC
TATCATCCAAAGTATGGGCTACAGAAACCGTGCCAAAAGACTTCTACAGAGTGAACCCGAAAATCCTTCCTTGCAGGAAACCAGTCTCAGTGTCCAACTC
TCTAACCTTGGAACTGTGAGAACTCTGAGGACAAAGCAGCGGATACAACCTCAAAAGACGTCTGTCTACATTGAATTGGGATCTGATTCTTCTGAAGATA
CCGTTAATAAGGCAACTTATTGCAGTGTGGGAGATCAAGAATTGTTACAAATCACCCCTCAAGGAACCAGGGATGAAATCAGTTTGGATTCTGCAAAAAA
GGGTGAAGCAGCATCTGGGTGTGAGAGTGAAACAAGCGTCTCTGAAGACTGCTCAGGGCTATCCTCTCAGAGTGACATTTTAACCACTCAGCAGAGGGAT
ACCATGCAACATAACCTGATAAAGCTCCAGCAGGAAATGGCTGAACTAGAAGCTGTGTTAGAACAGCATGGGAGCCAGCCTTCTAACAGCTACCCTTCCA
TCATAAGTGACTCTTCTGCCCTTGAGGACCTGCGAAATCCAGAACAAAGCACATCAGAAAAAGCAGTATTAACTTCACAGAAAAGTAGTGAATACCCTAT
AAGCCAGAATCCAGAAGGCCTTTCTGCTGACAAGTTTGAGGTGTCTGCAGATAGTTCTACCAGTAAAAATAAAGAACCAGGAGTGGAAAGGTCATCCCCT
TCTAAATGCCCATCATTAGATGATAGGTGGTACATGCACAGTTGCTCTGGGAGTCTTCAGAATAGAAACTACCCATCTCAAGAGGAGCTCATTAAGGTTG
TTGATGTGGAGGAGCAACAGCTGGAAGAGTCTGGGCCACACGATTTGACGGAAACATCTTACTTGCCAAGGCAAGATCTAGAGGGAACCCCTTACCTGGA
ATCTGGAATCAGCCTCTTCTCTGATGACCCTGAATCTGATCCTTCTGAAGACAGAGCCCCAGAGTCAGCTCGTGTTGGCAACATACCATCTTCAACCTCT
GCATTGAAAGTTCCCCAATTGAAAGTTGCAGAATCTGCCCAGAGTCCAGCTGCTGCTCATACTACTGATACTGCTGGGTATAATGCAATGGAAGAAAGTG
TGAGCAGGGAGAAGCCAGAATTGACAGCTTCAACAGAAAGGGTCAACAAAAGAATGTCCATGGTGGTGTCTGGCCTGACCCCAGAAGAATTTATGCTCGT
GTACAAGTTTGCCAGAAAACACCACATCACTTTAACTAATCTAATTACTGAAGAGACTACTCATGTTGTTATGAAAACAGATGCTGAGTTTGTGTGTGAA
CGGACACTGAAATATTTTCTAGGAATTGCGGGAGGAAAATGGGTAGTTAGCTATTTCTGGGTGACCCAGTCTATTAAAGAAAGAAAAATGCTGAATGAGC
ATGATTTTGAAGTCAGAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGA
AATCTGTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCATCATTC
ACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGATGTGTGAGGCACCTG
TGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGACT
GCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTAC
TGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAA
TCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCA
GCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTA
AAACCCTGTGTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGT
TCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAA
TCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATAC
AGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGGTGGAGGTTGCAGTGA
GCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAAAATGAAACTAGAAGAGATTTCTAAA
AGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAACCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTA
GTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAAAATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACA
GATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTTTTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCT
GAAGGAAGAAAAAGTGTTTTTCATAAACCCATTATCCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAG
TGAAGACTTGATTGTACAAAATACGTTTTGTAAATGTTGTGCTGTTAACACTGCAAATAAACTTGGTAGCAAACACTTCCA
  • BRCA1-F2 (forward primer)
  • BRCA1-R2 (reverse primer)
  • Mutually exclusive exon skipping

Frame 0

VP*FRILRGCCLAVAPWFPWQRKSAGITDKLKL
RLRGVSSLRLPGRGTGCGVSQITGPLRSGGLHPL
LWVKFIGTERNGFICSSR*RSTKCH*CYAENLR
VSHLSGVDQGTCLHKV*PHILQILHAETSQPEE
RAFTVSFM*E*YNQKEPTRKYEI*STC*RAIENH
LCFSA*HRFGVCKQL*FCKKGK*LS*TSKR*SF
YHPKYGLQKPCQKTSTE*TRKSFLAGNQSQCPT
L*PWNCENSEDKAADTTSKDVCLH*IGI*FF*RY
R**GNLLQCGRSRIVTNHPSRNQG*NQFGFCKK
G*SSIWV*E*NKRL*RLLRAILSE*HFNHSAEG
YHAT*PDKAPAGNG*TRSCVRTAWEPAF*QLPFH
HK*LFCP*GPAKSRTKHIRKSSINFTEK**IPY
KPESRRPFC*QV*GVCR*FYQ*K*RTRSGKVIP
F*MPIIR**VVHAQLLWESSE*KLPISRGAH*GC
*CGGATAGRVWATRFDGNILLAKARSRGNPLPG
IWNQPLL**P*I*SF*RQSPRVSSCWQHTIFNL
CIESSPIESCRICPESSCCSYY*YCWV*CNGRKC
EQGEARIDSFNRKGQQKNVHGGVWPDPRRIYAR
VQVCQKTPHHFN*SNY*RDYSCCYENRC*VCV*
TDTEIFSRNCGRKMGS*LFLGDPVY*RKKNAE*A
*F*SQRRCGQWKKPPRSKASKRIPGQKDLQGAR
NLLLWALHQHAHRSTGMDGTAVWCFCGEGAFII
HPWHRCPPNCGCAARCLDRGQWLPCNWADV*GTC
GDPRVGVGQCSTLPVPGAGHLPDTPDPPQPLLT
AASHRYRATGPQE*AYKVAFPGPGSSSHSSVLL
LSWLLNILCTSA*KGLLAMQGSLKDFLLEVSLGN
LP*AQNYGNFSPEKILKPFKRHQLSKMLIHYLS
ALFFLFRLLLA*GWKHRVAWPQENSWFP*VYFS
KTLCSQRQRVRPFNGRRVLGIDYVT*SQNSPWAV
LKCWSGTLGRKF*GRY*K*KGNLKPGHGGSRL*
SQHFGRPRWADHWRSGVRNQPGQHGETPSLLKI
QKLAGHGGGHL*SQLLRWLRQENHFSPGGGGCSE
PRSYHGTPAWVTVRLWLKKKKKKRKMKLEEISK
SLRYIC*ISKECVLKQQKIFKNRFPKTVF*FLI
SNK*NVYCCSSGI*SIPLKI*DLWHEYFISIK*Q
IPPGRKLLLSLR*FFSFAPCC*NHTAS*IILLA
EGRKSVFHKPIIQDCL*LLEGLGLP*PPQCARA
VKT*LYKIRFVNVVLLTLQINLVANTS

Frame 1

YLDFVF*EAAA*R*PLGFRGNGKARELQIN*NC
DCAA*AR*DFLDGGQAVGFLR*LGPCAQEAFTL
CSG*SSLEQKEMDLSALRVEEVQNVINAMQKILE
CPICLELIKEPVSTKCDHIFCKFCMLKLLNQKK
GPSQCPLCKNDITKRSLQESTRFSQLVEELLKI
ICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVS
IIQSMGYRNRAKRLLQSEPENPSLQETSLSVQL
SNLGTVRTLRTKQRIQPQKTSVYIELGSDSSED
TVNKATYCSVGDQELLQITPQGTRDEISLDSAKK
GEAASGCESETSVSEDCSGLSSQSDILTTQQRD
TMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPS
IISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPI
SQNPEGLSADKFEVSADSSTSKNKEPGVERSSP
SKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKV
VDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLE
SGISLFSDDPESDPSEDRAPESARVGNIPSSTS
ALKVPQLKVAESAQSPAAAHTTDTAGYNAMEES
VSREKPELTASTERVNKRMSMVVSGLTPEEFMLV
YKFARKHHITLTNLITEETTHVVMKTDAEFVCE
RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNE
HDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLE
ICCYGPFTNMPTDQLEWMVQLCGASVVKELSSF
TLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAP
VVTREWVLDSVALYQCQELDTYLIPQIPHSHY*L
QPATGTEPQDPKNELTKWPFQALGAPLTLQSFY
CPGY*IFYVHQPEKDFWLCKGPLKIFCLKSPLE
ICHEHKIMVIFHLRRF*NHLNATN*ARC*FIIYQ
PYSFYSGCCWLRAGSTEWLGLKRIAGFPKFTSL
KPCVHKGRESDPSMEGECLGSIM*LKVRIVLGQ
FSNVGVEHWGGNSEAGIRNEKET*NLGMVAHACN
PSTLGGQGGQITGGQEFETSLANMVKPHLY*KY
RN*PVMVVDTCNPSYSGG*GRRITSAREVEVAV
SQDHTTALQPG*Q*DCGSKKKKKKGK*N*KRFLK
V*DIFARFLKNVF*NSRRFSRTGFQRQSSNSSL
VISKMFIVVALVYNPFLLKYKTSGMNISYL*ND
RSHQEGSCCFL*GDFFPLLPVAETIQLHK*FCLL
KEEKVFFINPLSRTVYSCWKD*VFPSPPSVQGQ
*RLDCTKYVL*MLCC*HCK*TW*QTLP

Frame 2

TLISYSERLLLSGSPLVSVATEKRGNYR*IKTA
TARRELAETSWTGDRLWGFSDNWAPALRRPSPS
ALGKVHWNRKKWIYLLFALKKYKMSLMLCRKS*
SVPSVWS*SRNLSPQSVTTYFANFAC*NFSTRRK
GLHSVLYVRMI*PKGAYKKVRDLVNLLKSY*KS
FVLFSLTQVWSMQTAIILQKRKITLLNI*KMKF
LSSKVWATETVPKDFYRVNPKILPCRKPVSVSNS
LTLEL*EL*GQSSGYNLKRRLSTLNWDLILLKI
PLIRQLIAVWEIKNCYKSPLKEPGMKSVWILQK
RVKQHLGVRVKQASLKTAQGYPLRVTF*PLSRGI
PCNIT**SSSRKWLN*KLC*NSMGASLLTATLP
S*VTLLPLRTCEIQNKAHQKKQY*LHRKVVNTL
*ARIQKAFLLTSLRCLQIVLPVKIKNQEWKGHPL
LNAHH*MIGGTCTVALGVFRIETTHLKRSSLRL
LMWRSNSWKSLGHTI*RKHLTCQGKI*REPLTW
NLESASSLMTLNLILLKTEPQSQLVLATYHLQPL
H*KFPN*KLQNLPRVQLLLILLILLGIMQWKKV
*AGRSQN*QLQQKGSTKECPWWCLA*PQKNLCS
CTSLPENTTSL*LI*LLKRLLMLL*KQMLSLCVN
GH*NIF*ELREENG*LAISG*PSLLKKEKC*MS
MILKSEEMWSMEETTKVQSEQENPRTERSSGG*
KSVAMGPSPTCPQINWNGWYSCVVLLW*RSFHHS
PLAQVSTQLWLCSQMPGQRTMASMQLGRCVRHL
W*PESGCWTV*HSTSARSWTPT*YPRSPTATTD
CSQPQVQSHRTPRMSLQSGLSRPWELLSLFSPST
VLATKYFMYISLKRTSGYARVP*RFSA*SLPWK
SAMSTKLW*FFT*EDFKTI*TPPIEQDADSLFI
SPILSIQAVVGLGLEAQSGLASRE*LVSLSLLL*
NPVFTKAESQTLQWKESAWDRLCDLKSE*SLGS
SQMLEWNIGEEILRQVLEMKRKLETWAWWLTPV
IPALWEAKVGRSLEVRSSKPAWPTW*NPISTKNT
EISRSWWWTPVIPATQVAKAGESLQPGRWRLQ*
AKIIPRHSSLGDSETVAQKKKKKKENETRRDF*
KSEIYLLDF*RMCSKTAEDFQEPVSKDSLLIPH*
**VKCLLL*LWYIIHSS*NIRPLA*IFHIYKMT
DPTRKEAVAFFEVIFFLCSLLLKPYSFINNFAC
*RKKKCFS*THYPGLFIAVGRTRSSLAPPVCKGS
EDLIVQNTFCKCCAVNTANKLGSKHF

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