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Sequences

Sequence C11orf17.gAug05

GTTGCGCGCATGCGCCTTGACGAGTGAGCCGGGTGAGGGGGCTCCCTAAGTAGCGGAAGGGGTAGATGAAAATGGAAGGGGCGGGCGCGCTAGGCCTAGT CCTGGCTGGGCTCCCGCTGGAGTGTGCGTTGGGGGCGGACCAGGAGCGGTGGTCTCCAGGGAGGTCGAGGCTGGGGCTCCCACCCGGATTTGGAGCAGGG TCGCCGCGGCCCAGCTGACCCGCCGGCGTTTGTACGTTGTGTGCCCACTCAGGGAGCCATGGACAACTGTTTGGCGGCCGCAGCGCTGAATGGGGTGGAC CGACGTTCCCTGCAGCGTTCAGCAAGGCTGGCTCTAGAAGTGCTGGAGAGGGCCAAGAGGAGGGCGGTGGACTGGCATGCCCTGGAGCGTCCCAAAGGCT GCATGGGGGTCCTTGCCCGGGAGGCGCCCCACCTAGAGAAACAGCCGGCAGCCGGCCCGCAGCGCGTTCTCCCGGGAGAGAAATATTATTCATCTGTGCC AGAGGAAGGAGGGGCAACCCATGTCTATCGTTATCACAGAGGCGAGTCGAAGCTGCACATGTGCTTGGACATAGGGAATGGTCAGGCTGAGAACATCTCT AAGGACCTCTACATAGAAGTATATCCAGGGACCTATTCTGTCACTGTGGGCTCAAATGACTTAACCAAGAAGACTCATGTGGTAGCAGTTGATTCTGGAC AAAGCGTGGACCTGGTCTTCCCTGTGTGATGTTGACCATCACTGCCATCACATCACCTTTTTTTAAGTAGTAAGAATAAAGCCACTGTATGATTCTCTTA ATAGCTATACATTAATCCTGTTTTTAGTGCTGACTGGGTCAGCCTTCCGGGAACTGGAGTCTGTCTCTTTCAGTGCTTTTTTGTTTGTTTGGTTGGTTTT TTTTTGAGACAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGTTCCGCCTCCCGGGTTCACACCATTCTCCTGCC TCAGCCTCCCGAGTAGCTGGCACTACAGGCACCCGCCACCATGCCCGGCTATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGA TGGTCTCGATCTCTTGACCTCGTGATCCACCCACCTTGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTCAGTGCCTTTTTTA ACTTGAGGGTGTAGAGGTCCTCCACGCTTGTTTGCCTGAAAGTAATATAATGATGCTGTCTGAACAGGTTTTACTGCTTGCTTTCCAAGTAAAGGTTAAT TATGATAATAAAGAGATTTGGAAATGAAGAGAATTCATTTTTATTAAGAGGTGAAACAAAATGTCACTCATGTACAACTAGGCTTTATGGGAAGGTGGCA GAGTGGCTGTGGACACATTTGCCCAAAGCAGGCTGACCCCCTCTTCCACGGAAGAGGCATCTTAAAGCAGTTTCACCAGGGCCCTGGCAGGGAGCCCCAG GGCAGGATCCCACATTCCTATAGCCCTCACAACAGGTGCCTTCCTGCTGCTTATCTGCAGGGAGGTCTTCGTGGGGTGGAGATACTGGTGGTTATTTGAC TGTTACCTGTGGCCTGTCCTCTGCCTCCTTCCGTTGAAGAAGGCCTTGTCAGCCACTCTGTATAACTCTCCTCGAATATTTACCATGTTTATTCTTTACC TATAAAAGGGGGAAAAATTCCATACATTGTTATGCT

C11orf17-F2 (forward primer)
C11orf17-R2 (reverse primer)
Single exon skipping

Frame 0

VARMRLDE*AG*GGSLSSGRGR*KWKGRAR*A* SWLGSRWSVRWGRTRSGGLQGGRGWGSHPDLEQG RRGPADPPAFVRCVPTQGAMDNCLAAAALNGVD RRSLQRSARLALEVLERAKRRAVDWHALERPKG CMGVLAREAPHLEKQPAAGPQRVLPGEKYYSSVP EEGGATHVYRYHRGESKLHMCLDIGNGQAENIS KDLYIEVYPGTYSVTVGSNDLTKKTHVVAVDSG QSVDLVFPV*C*PSLPSHHLFLSSKNKATV*FS* *LYINPVFSADWVSLPGTGVCLFQCFFVCLVGF FLRQSHSVAQAGVQWRDLGSLQVPPPGFTPFSC LSLPSSWHYRHPPPCPAIFFVFLVETGFHHVGQD GLDLLTS*STHLGLPKCWDYRREPPRPASVPFL T*GCRGPPRLFA*K*YNDAV*TGFTACFPSKG* L***RDLEMKRIHFY*EVKQNVTHVQLGFMGRWQ SGCGHICPKQADPLFHGRGILKQFHQGPGREPQ GRIPHSYSPHNRCLPAAYLQGGLRGVEILVVI* LLPVACPLPPSVEEGLVSHSV*LSSNIYHVYSLP IKGGKIPYIVM

Frame 1

LRACALTSEPGEGAP*VAEGVDENGRGGRARPS PGWAPAGVCVGGGPGAVVSREVEAGAPTRIWSR VAAAQLTRRRLYVVCPLREPWTTVWRPQR*MGWT DVPCSVQQGWL*KCWRGPRGGRWTGMPWSVPKA AWGSLPGRRPT*RNSRQPARSAFSRERNIIHLC QRKEGQPMSIVITEASRSCTCAWT*GMVRLRTSL RTST*KYIQGPILSLWAQMT*PRRLMW*QLILD KAWTWSSLCDVDHHCHHITFF*VVRIKPLYDSL NSYTLILFLVLTGSAFRELESVSFSAFLFVWLVF F*DSLTLLPRLECSGVISAHCKFRLPGSHHSPA SASRVAGTTGTRHHARLFFLYF**RRGFTMLAR MVSIS*PRDPPTLASQSVGITGVSHRARPQCLF* LEGVEVLHACLPESNIMMLSEQVLLLAFQVKVN YDNKEIWK*REFIFIKR*NKMSLMYN*ALWEGG RVAVDTFAQSRLTPSSTEEAS*SSFTRALAGSPR AGSHIPIALTTGAFLLLICREVFVGWRYWWLFD CYLWPVLCLLPLKKALSATLYNSPRIFTMFILY L*KGEKFHTLLC

Frame 2

CAHAP*RVSRVRGLPK*RKG*MKMEGAGALGLV LAGLPLECALGADQERWSPGRSRLGLPPGFGAG SPRPS*PAGVCTLCAHSGSHGQLFGGRSAEWGG PTFPAAFSKAGSRSAGEGQEEGGGLACPGASQRL HGGPCPGGAPPRETAGSRPAARSPGREILFICA RGRRGNPCLSLSQRRVEAAHVLGHREWSG*EHL *GPLHRSISRDLFCHCGLK*LNQEDSCGSS*FWT KRGPGLPCVMLTITAITSPFFK**E*SHCMILL IAIH*SCF*C*LGQPSGNWSLSLSVLFCLFGWF FFETVSLCCPGWSAVA*SRLTASSASRVHTILLP QPPE*LALQAPATMPGYFFCIFSRDGVSPCWPG WSRSLDLVIHPPWPPKVLGLQA*ATAPGLSAFF NLRV*RSSTLVCLKVI**CCLNRFYCLLSK*RLI MIIKRFGNEENSFLLRGETKCHSCTTRLYGKVA EWLWTHLPKAG*PPLPRKRHLKAVSPGPWQGAP GQDPTFL*PSQQVPSCCLSAGRSSWGGDTGGYLT VTCGLSSASFR*RRPCQPLCITLLEYLPCLFFT YKRGKNSIHCYA

Sequence C11orf17.eAug05

GCTGCGCCGGCGCCGCCGGGAGCGCTAGGCCTGGTCCCTCTTCCTAGAATAGCGTTGCGCGCATGCGCCTTGACGAGTGAGCCGGGGAGCCATGGACAAC TGTTTGGCGGCCGCAGCGCTGAATGGGGTGGACCGACGTTCCCTGCAGCGTTCAGCAAGGCTGGCTCTAGAAGTGCTGGAGAGGGCCAAGAGGAGGGCGG TGGACTGGCATGCCCTGGAGCGTCCCAAAGGCTGCATGGGGGTCCTTGCCCGGGAGGCGCCCCACCTAGAGAAACAGCCGGCAGCCGGCCCGCAGCGCGT TCTCCCGGGAGAGAGAGAAGAGAGACCCCCAACCCTTAGTGCTTCCTTCAGAACAATGGCTGAATTCATGGACTATACTTCAAGTCAGTGTGGGAAATAT TATTCATCTGTGCCAGAGGAAGGAGGGGCAACCCATGTCTATCGTTATCACAGAGGCGAGTCGAAGCTGCACATGTGCTTGGACATAGGGAATGGTCAGG CTGAGAACATCTCTAAGGACCTCTACATAGAAGTATATCCAGGGACCTATTCTGTCACTGTGGGCTCAAATGACTTAACCAAGAAGACTCATGTGGTAGC AGTTGATTCTGGACAAAGCGTGGACCTGGTCTTCCCTGTGTGATGTTGACCATCACTGCCATCACATCACCTTTTTTTAAGTAGTAAGAATAAAGCCACT GTATGATTCTCTTAATAGCTATACATTAATCCTGTTTTTAGTGCTGACTGGGTCAGCCTTCCGGGAACTGGAGTCTGTCTCTTTCAGTGCTTTTTTGTTT GTTTGGTTGGTTTTTTTTTGAGACAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGTTCCGCCTCCCGGGTTCAC ACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGCACTACAGGCACCCGCCACCATGCCCGGCTATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCAC CATGTTGGCCAGGATGGTCTCGATCTCTTGACCTCGTGATCCACCCACCTTGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCT CAGTGCCTTTTTTAACTTGAGGGTGTAGAGGTCCTCCACGCTTGTTTGCCTGAAAGTAATATAATGATGCTGTCTGAACAGGTTTTACTGCTTGCTTTCC AAGTAAAGGTTAATTATGATAATAAAGAGATTTGGAAATGAAGAGAATTCATTTTTATTAAGAGGTGAAACAAAATGTCACTCATGTACAACTAGGCTTT ATGGGAAGGTGGCAGAGTGGCTGTGGACACATTTGCCCAAAGCAGGCTGACCCCCTCTTCCACGGAAGAGGCATCTTAAAGCAGTTTCACCAGGGCCCTG GCAGGGAGCCCCAGGGCAGGATCCCACATTCCTATAGCCCTCACAACAGGTGCCTTCCTGCTGCTTATCTGCAGGGAGGTCTTCGTGGGGTGGAGATACT GGTGGTTATTTGACTGTTACCTGTGGCCTGTCCTCTGCCTCCTTCCGTTGAAGAAGGCCTTGTCAGCCACTCTGTATAACTCTCCTCGAATATTTACCAT GTTTATTCTTTACCTATAAAAGGGGGAAAAATTCCATACATTGTTATGCT

C11orf17-F2 (forward primer)
C11orf17-R2 (reverse primer)
Single exon skipping

Frame 0

AAPAPPGALGLVPLPRIALRACALTSEPGSHGQ LFGGRSAEWGGPTFPAAFSKAGSRSAGEGQEEGG GLACPGASQRLHGGPCPGGAPPRETAGSRPAAR SPGRERRETPNP*CFLQNNG*IHGLYFKSVWEI LFICARGRRGNPCLSLSQRRVEAAHVLGHREWSG *EHL*GPLHRSISRDLFCHCGLK*LNQEDSCGS S*FWTKRGPGLPCVMLTITAITSPFFK**E*SH CMILLIAIH*SCF*C*LGQPSGNWSLSLSVLFCL FGWFFFETVSLCCPGWSAVA*SRLTASSASRVH TILLPQPPE*LALQAPATMPGYFFCIFSRDGVS PCWPGWSRSLDLVIHPPWPPKVLGLQA*ATAPGL SAFFNLRV*RSSTLVCLKVI**CCLNRFYCLLS K*RLIMIIKRFGNEENSFLLRGETKCHSCTTRL YGKVAEWLWTHLPKAG*PPLPRKRHLKAVSPGPW QGAPGQDPTFL*PSQQVPSCCLSAGRSSWGGDT GGYLTVTCGLSSASFR*RRPCQPLCITLLEYLP CLFFTYKRGKNSIHCYA

Frame 1

LRRRRRER*AWSLFLE*RCAHAP*RVSRGAMDN CLAAAALNGVDRRSLQRSARLALEVLERAKRRA VDWHALERPKGCMGVLAREAPHLEKQPAAGPQRV LPGEREERPPTLSASFRTMAEFMDYTSSQCGKY YSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQ AENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVA VDSGQSVDLVFPV*C*PSLPSHHLFLSSKNKAT V*FS**LYINPVFSADWVSLPGTGVCLFQCFFV CLVGFFLRQSHSVAQAGVQWRDLGSLQVPPPGFT PFSCLSLPSSWHYRHPPPCPAIFFVFLVETGFH HVGQDGLDLLTS*STHLGLPKCWDYRREPPRPA SVPFLT*GCRGPPRLFA*K*YNDAV*TGFTACFP SKG*L***RDLEMKRIHFY*EVKQNVTHVQLGF MGRWQSGCGHICPKQADPLFHGRGILKQFHQGP GREPQGRIPHSYSPHNRCLPAAYLQGGLRGVEIL VVI*LLPVACPLPPSVEEGLVSHSV*LSSNIYH VYSLPIKGGKIPYIVM

Frame 2

CAGAAGSARPGPSS*NSVARMRLDE*AGEPWTT VWRPQR*MGWTDVPCSVQQGWL*KCWRGPRGGR WTGMPWSVPKAAWGSLPGRRPT*RNSRQPARSA FSREREKRDPQPLVLPSEQWLNSWTILQVSVGNI IHLCQRKEGQPMSIVITEASRSCTCAWT*GMVR LRTSLRTST*KYIQGPILSLWAQMT*PRRLMW* QLILDKAWTWSSLCDVDHHCHHITFF*VVRIKPL YDSLNSYTLILFLVLTGSAFRELESVSFSAFLF VWLVFF*DSLTLLPRLECSGVISAHCKFRLPGS HHSPASASRVAGTTGTRHHARLFFLYF**RRGFT MLARMVSIS*PRDPPTLASQSVGITGVSHRARP QCLF*LEGVEVLHACLPESNIMMLSEQVLLLAF QVKVNYDNKEIWK*REFIFIKR*NKMSLMYN*AL WEGGRVAVDTFAQSRLTPSSTEEAS*SSFTRAL AGSPRAGSHIPIALTTGAFLLLICREVFVGWRY WWLFDCYLWPVLCLLPLKKALSATLYNSPRIFTM FILYL*KGEKFHTLLC

Sequence C11orf17.dAug05

GCTGCGCCGGCGCCGCCGGGAGCGCTAGGCCTGGTCCCTCTTCCTAGAATAGCGTTGCGCGCATGCGCCTTGACGAGTGAGCCGGGGAGCCATGGACAAC TGTTTGGCGGCCGCAGCGCTGAATGGGGTGGACCGACGTTCCCTGCAGCGTTCAGCAAGGCTGGCTCTAGAAGTGCTGGAGAGGGCCAAGAGGAGGGCGG TGGACTGGCATGCCCTGGAGCGTCCCAAAGGCTGCATGGGGGTCCTTGCCCGGGAGGCGCCCCACCTAGAGAAACAGCCGGCAGCCGGCCCGCAGCGCGT TCTCCCGGGAGAGAAATATTATTCATCTGTGCCAGAGGAAGGAGGGGCAACCCATGTCTATCGTTATCACAGAGGCGAGTCGAAGCTGCACATGTGCTTG GACATAGGGAATGGTCAGAGAAAAGACAGAAAAAAGACATCCCTTGGTCCTGGAGGCAGCTATCAAATATCAGAGCATGCTCCAGAGGCATCCCAGCCTG CTGAGAACATCTCTAAGGACCTCTACATAGAAGTATATCCAGGGACCTATTCTGTCACTGTGGGCTCAAATGACTTAACCAAGAAGACTCATGTGGTAGC AGTTGATTCTGGACAAAGCGTGGACCTGGTCTTCCCTGTGTGATGTTGACCATCACTGCCATCACATCACCTTTTTTTAAGTAGTAAGAATAAAGCCACT GTATGATTCTCTTAATAGCTATACATTAATCCTGTTTTTAGTGCTGACTGGGTCAGCCTTCCGGGAACTGGAGTCTGTCTCTTTCAGTGCTTTTTTGTTT GTTTGGTTGGTTTTTTTTTGAGACAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGTTCCGCCTCCCGGGTTCAC ACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGCACTACAGGCACCCGCCACCATGCCCGGCTATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCAC CATGTTGGCCAGGATGGTCTCGATCTCTTGACCTCGTGATCCACCCACCTTGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCT CAGTGCCTTTTTTAACTTGAGGGTGTAGAGGTCCTCCACGCTTGTTTGCCTGAAAGTAATATAATGATGCTGTCTGAACAGGTTTTACTGCTTGCTTTCC AAGTAAAGGTTAATTATGATAATAAAGAGATTTGGAAATGAAGAGAATTCATTTTTATTAAGAGGTGAAACAAAATGTCACTCATGTACAACTAGGCTTT ATGGGAAGGTGGCAGAGTGGCTGTGGACACATTTGCCCAAAGCAGGCTGACCCCCTCTTCCACGGAAGAGGCATCTTAAAGCAGTTTCACCAGGGCCCTG GCAGGGAGCCCCAGGGCAGGATCCCACATTCCTATAGCCCTCACAACAGGTGCCTTCCTGCTGCTTATCTGCAGGGAGGTCTTCGTGGGGTGGAGATACT GGTGGTTATTTGACTGTTACCTGTGGCCTGTCCTCTGCCTCCTTCCGTTGAAGAAGGCCTTGTCAGCCACTCTGTATAACTCTCCTCGAATATTTACCAT GTTTATTCTTTACCTATAAAAGGGGGAAAAATTCCATACATTGTTATGCT

C11orf17-F2 (forward primer)
C11orf17-R2 (reverse primer)
Single exon skipping

Frame 0

AAPAPPGALGLVPLPRIALRACALTSEPGSHGQ LFGGRSAEWGGPTFPAAFSKAGSRSAGEGQEEGG GLACPGASQRLHGGPCPGGAPPRETAGSRPAAR SPGREILFICARGRRGNPCLSLSQRRVEAAHVL GHREWSEKRQKKDIPWSWRQLSNIRACSRGIPAC *EHL*GPLHRSISRDLFCHCGLK*LNQEDSCGS S*FWTKRGPGLPCVMLTITAITSPFFK**E*SH CMILLIAIH*SCF*C*LGQPSGNWSLSLSVLFCL FGWFFFETVSLCCPGWSAVA*SRLTASSASRVH TILLPQPPE*LALQAPATMPGYFFCIFSRDGVS PCWPGWSRSLDLVIHPPWPPKVLGLQA*ATAPGL SAFFNLRV*RSSTLVCLKVI**CCLNRFYCLLS K*RLIMIIKRFGNEENSFLLRGETKCHSCTTRL YGKVAEWLWTHLPKAG*PPLPRKRHLKAVSPGPW QGAPGQDPTFL*PSQQVPSCCLSAGRSSWGGDT GGYLTVTCGLSSASFR*RRPCQPLCITLLEYLP CLFFTYKRGKNSIHCYA

Frame 1

LRRRRRER*AWSLFLE*RCAHAP*RVSRGAMDN CLAAAALNGVDRRSLQRSARLALEVLERAKRRA VDWHALERPKGCMGVLAREAPHLEKQPAAGPQRV LPGEKYYSSVPEEGGATHVYRYHRGESKLHMCL DIGNGQRKDRKKTSLGPGGSYQISEHAPEASQP AENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVA VDSGQSVDLVFPV*C*PSLPSHHLFLSSKNKAT V*FS**LYINPVFSADWVSLPGTGVCLFQCFFV CLVGFFLRQSHSVAQAGVQWRDLGSLQVPPPGFT PFSCLSLPSSWHYRHPPPCPAIFFVFLVETGFH HVGQDGLDLLTS*STHLGLPKCWDYRREPPRPA SVPFLT*GCRGPPRLFA*K*YNDAV*TGFTACFP SKG*L***RDLEMKRIHFY*EVKQNVTHVQLGF MGRWQSGCGHICPKQADPLFHGRGILKQFHQGP GREPQGRIPHSYSPHNRCLPAAYLQGGLRGVEIL VVI*LLPVACPLPPSVEEGLVSHSV*LSSNIYH VYSLPIKGGKIPYIVM

Frame 2

CAGAAGSARPGPSS*NSVARMRLDE*AGEPWTT VWRPQR*MGWTDVPCSVQQGWL*KCWRGPRGGR WTGMPWSVPKAAWGSLPGRRPT*RNSRQPARSA FSRERNIIHLCQRKEGQPMSIVITEASRSCTCAW T*GMVREKTEKRHPLVLEAAIKYQSMLQRHPSL LRTSLRTST*KYIQGPILSLWAQMT*PRRLMW* QLILDKAWTWSSLCDVDHHCHHITFF*VVRIKPL YDSLNSYTLILFLVLTGSAFRELESVSFSAFLF VWLVFF*DSLTLLPRLECSGVISAHCKFRLPGS HHSPASASRVAGTTGTRHHARLFFLYF**RRGFT MLARMVSIS*PRDPPTLASQSVGITGVSHRARP QCLF*LEGVEVLHACLPESNIMMLSEQVLLLAF QVKVNYDNKEIWK*REFIFIKR*NKMSLMYN*AL WEGGRVAVDTFAQSRLTPSSTEEAS*SSFTRAL AGSPRAGSHIPIALTTGAFLLLICREVFVGWRY WWLFDCYLWPVLCLLPLKKALSATLYNSPRIFTM FILYL*KGEKFHTLLC

Sequence C11orf17.cAug05

GCTGCGCCGGCGCCGCCGGGAGCGCTAGGCCTGGTCCCTCTTCCTAGAATAGCGTTGCGCGCATGCGCCTTGACGAGTGAGCCGGGGAGCCATGGACAAC TGTTTGGCGGCCGCAGCGCTGAATGGGGTGGACCGACGTTCCCTGCAGCGTTCAGCAAGGCTGGCTCTAGAAGTGCTGGAGAGGGCCAAGAGGAGGGCGG TGGACTGGCATGCCCTGGAGCGTCCCAAAGGCTGCATGGGGGTCCTTGCCCGGGAGGCGCCCCACCTAGAGAAACAGCCGGCAGCCGGCCCGCAGCGCGT TCTCCCGGGAGAGAGAGAAGAGAGACCCCCAACCCTTAGTGCTTCCTTCAGAACAATGGCTGAATTCATGGACTATACTTCAAGTCAGTGTGGGAAATAT TATTCATCTGTGCCAGAGGAAGGAGGGGCAACCCATGTCTATCGTTATCACAGAGGCGAGTCGAAGCTGCACATGTGCTTGGACATAGGGAATGGTCAGA GAAAAGACAGAAAAAAGACATCCCTTGGTCCTGGAGGCAGCTATCAAATATCAGAGCATGCTCCAGAGGCATCCCAGCCTGCTGAGAACATCTCTAAGGA CCTCTACATAGAAGTATATCCAGGGACCTATTCTGTCACTGTGGGCTCAAATGACTTAACCAAGAAGACTCATGTGGTAGCAGTTGATTCTGGACAAAGC GTGGACCTGGTCTTCCCTGTGTGATGTTGACCATCACTGCCATCACATCACCTTTTTTTAAGTAGTAAGAATAAAGCCACTGTATGATTCTCTTAATAGC TATACATTAATCCTGTTTTTAGTGCTGACTGGGTCAGCCTTCCGGGAACTGGAGTCTGTCTCTTTCAGTGCTTTTTTGTTTGTTTGGTTGGTTTTTTTTT GAGACAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGTTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGC CTCCCGAGTAGCTGGCACTACAGGCACCCGCCACCATGCCCGGCTATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGATGGTC TCGATCTCTTGACCTCGTGATCCACCCACCTTGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTCAGTGCCTTTTTTAACTTG AGGGTGTAGAGGTCCTCCACGCTTGTTTGCCTGAAAGTAATATAATGATGCTGTCTGAACAGGTTTTACTGCTTGCTTTCCAAGTAAAGGTTAATTATGA TAATAAAGAGATTTGGAAATGAAGAGAATTCATTTTTATTAAGAGGTGAAACAAAATGTCACTCATGTACAACTAGGCTTTATGGGAAGGTGGCAGAGTG GCTGTGGACACATTTGCCCAAAGCAGGCTGACCCCCTCTTCCACGGAAGAGGCATCTTAAAGCAGTTTCACCAGGGCCCTGGCAGGGAGCCCCAGGGCAG GATCCCACATTCCTATAGCCCTCACAACAGGTGCCTTCCTGCTGCTTATCTGCAGGGAGGTCTTCGTGGGGTGGAGATACTGGTGGTTATTTGACTGTTA CCTGTGGCCTGTCCTCTGCCTCCTTCCGTTGAAGAAGGCCTTGTCAGCCACTCTGTATAACTCTCCTCGAATATTTACCATGTTTATTCTTTACCTATAA AAGGGGGAAAAATTCCATACATTGTTATGCT

C11orf17-F2 (forward primer)
C11orf17-R2 (reverse primer)
Single exon skipping

Frame 0

AAPAPPGALGLVPLPRIALRACALTSEPGSHGQ LFGGRSAEWGGPTFPAAFSKAGSRSAGEGQEEGG GLACPGASQRLHGGPCPGGAPPRETAGSRPAAR SPGRERRETPNP*CFLQNNG*IHGLYFKSVWEI LFICARGRRGNPCLSLSQRRVEAAHVLGHREWSE KRQKKDIPWSWRQLSNIRACSRGIPAC*EHL*G PLHRSISRDLFCHCGLK*LNQEDSCGSS*FWTK RGPGLPCVMLTITAITSPFFK**E*SHCMILLIA IH*SCF*C*LGQPSGNWSLSLSVLFCLFGWFFF ETVSLCCPGWSAVA*SRLTASSASRVHTILLPQ PPE*LALQAPATMPGYFFCIFSRDGVSPCWPGWS RSLDLVIHPPWPPKVLGLQA*ATAPGLSAFFNL RV*RSSTLVCLKVI**CCLNRFYCLLSK*RLIM IIKRFGNEENSFLLRGETKCHSCTTRLYGKVAEW LWTHLPKAG*PPLPRKRHLKAVSPGPWQGAPGQ DPTFL*PSQQVPSCCLSAGRSSWGGDTGGYLTV TCGLSSASFR*RRPCQPLCITLLEYLPCLFFTYK RGKNSIHCYA

Frame 1

LRRRRRER*AWSLFLE*RCAHAP*RVSRGAMDN CLAAAALNGVDRRSLQRSARLALEVLERAKRRA VDWHALERPKGCMGVLAREAPHLEKQPAAGPQRV LPGEREERPPTLSASFRTMAEFMDYTSSQCGKY YSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQ RKDRKKTSLGPGGSYQISEHAPEASQPAENISKD LYIEVYPGTYSVTVGSNDLTKKTHVVAVDSGQS VDLVFPV*C*PSLPSHHLFLSSKNKATV*FS** LYINPVFSADWVSLPGTGVCLFQCFFVCLVGFFL RQSHSVAQAGVQWRDLGSLQVPPPGFTPFSCLS LPSSWHYRHPPPCPAIFFVFLVETGFHHVGQDG LDLLTS*STHLGLPKCWDYRREPPRPASVPFLT* GCRGPPRLFA*K*YNDAV*TGFTACFPSKG*L* **RDLEMKRIHFY*EVKQNVTHVQLGFMGRWQS GCGHICPKQADPLFHGRGILKQFHQGPGREPQGR IPHSYSPHNRCLPAAYLQGGLRGVEILVVI*LL PVACPLPPSVEEGLVSHSV*LSSNIYHVYSLPI KGGKIPYIVM

Frame 2

CAGAAGSARPGPSS*NSVARMRLDE*AGEPWTT VWRPQR*MGWTDVPCSVQQGWL*KCWRGPRGGR WTGMPWSVPKAAWGSLPGRRPT*RNSRQPARSA FSREREKRDPQPLVLPSEQWLNSWTILQVSVGNI IHLCQRKEGQPMSIVITEASRSCTCAWT*GMVR EKTEKRHPLVLEAAIKYQSMLQRHPSLLRTSLR TST*KYIQGPILSLWAQMT*PRRLMW*QLILDKA WTWSSLCDVDHHCHHITFF*VVRIKPLYDSLNS YTLILFLVLTGSAFRELESVSFSAFLFVWLVFF *DSLTLLPRLECSGVISAHCKFRLPGSHHSPASA SRVAGTTGTRHHARLFFLYF**RRGFTMLARMV SIS*PRDPPTLASQSVGITGVSHRARPQCLF*L EGVEVLHACLPESNIMMLSEQVLLLAFQVKVNYD NKEIWK*REFIFIKR*NKMSLMYN*ALWEGGRV AVDTFAQSRLTPSSTEEAS*SSFTRALAGSPRA GSHIPIALTTGAFLLLICREVFVGWRYWWLFDCY LWPVLCLLPLKKALSATLYNSPRIFTMFILYL* KGEKFHTLLC

Sequence C11orf17.bAug05

GTTGCGCGCATGCGCCTTGACGAGTGAGCCGGGTGAGGGGGCTCCCTAAGTAGCGGAAGGGGTAGATGAAAATGGAAGGGGCGGGCGCGCTAGGCCTAGT CCTGGCTGGGCTCCCGCTGGAGTGTGCGTTGGGGGCGGACCAGGAGCGGTGGTCTCCAGGGAGGTCGAGGCTGGGGCTCCCACCCGGATTTGGAGCAGGG TCGCCGCGGCCCAGCTGACCCGCCGGCGTTTGTACGTTGTGTGCCCACTCAGGGAGCCATGGACAACTGTTTGGCGGCCGCAGCGCTGAATGGGGTGGAC CGACGTTCCCTGCAGCGTTCAGCAAGGCTGGCTCTAGAAGTGCTGGAGAGGGCCAAGAGGAGGGCGGTGGACTGGCATGCCCTGGAGCGTCCCAAAGGCT GCATGGGGGTCCTTGCCCGGGAGGCGCCCCACCTAGAGAAACAGCCGGCAGCCGGCCCGCAGCGCGTTCTCCCGGGAGAGAAATATTATTCATCTGTGCC AGAGGAAGGAGGGGCAACCCATGTCTATCGTTATCACAGAGGCGAGTCGAAGCTGCACATGTGCTTGGACATAGGGAATGGTCAGAGAAAAGACAGAAAA AAGACATCCCTTGGTCCTGGAGGCAGCTATCAAATATCAGAGCATGCTCCAGAGGCATCCCAGCCTGCTGAGAACATCTCTAAGGACCTCTACATAGAAG TATATCCAGGGACCTATTCTGTCACTGTGGGCTCAAATGACTTAACCAAGAAGACTCATGTGGTAGCAGTTGATTCTGGACAAAGCGTGGACCTGGTCTT CCCTGTGTGATGTTGACCATCACTGCCATCACATCACCTTTTTTTAAGTAGTAAGAATAAAGCCACTGTATGATTCTCTTAATAGCTATACATTAATCCT GTTTTTAGTGCTGACTGGGTCAGCCTTCCGGGAACTGGAGTCTGTCTCTTTCAGTGCTTTTTTGTTTGTTTGGTTGGTTTTTTTTTGAGACAGTCTCACT CTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGTTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTG GCACTACAGGCACCCGCCACCATGCCCGGCTATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACC TCGTGATCCACCCACCTTGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTCAGTGCCTTTTTTAACTTGAGGGTGTAGAGGTC CTCCACGCTTGTTTGCCTGAAAGTAATATAATGATGCTGTCTGAACAGGTTTTACTGCTTGCTTTCCAAGTAAAGGTTAATTATGATAATAAAGAGATTT GGAAATGAAGAGAATTCATTTTTATTAAGAGGTGAAACAAAATGTCACTCATGTACAACTAGGCTTTATGGGAAGGTGGCAGAGTGGCTGTGGACACATT TGCCCAAAGCAGGCTGACCCCCTCTTCCACGGAAGAGGCATCTTAAAGCAGTTTCACCAGGGCCCTGGCAGGGAGCCCCAGGGCAGGATCCCACATTCCT ATAGCCCTCACAACAGGTGCCTTCCTGCTGCTTATCTGCAGGGAGGTCTTCGTGGGGTGGAGATACTGGTGGTTATTTGACTGTTACCTGTGGCCTGTCC TCTGCCTCCTTCCGTTGAAGAAGGCCTTGTCAGCCACTCTGTATAACTCTCCTCGAATATTTACCATGTTTATTCTTTACCTATAAAAGGGGGAAAAATT CCATACATTGTTATGCT

C11orf17-F2 (forward primer)
C11orf17-R2 (reverse primer)
Single exon skipping

Frame 0

VARMRLDE*AG*GGSLSSGRGR*KWKGRAR*A* SWLGSRWSVRWGRTRSGGLQGGRGWGSHPDLEQG RRGPADPPAFVRCVPTQGAMDNCLAAAALNGVD RRSLQRSARLALEVLERAKRRAVDWHALERPKG CMGVLAREAPHLEKQPAAGPQRVLPGEKYYSSVP EEGGATHVYRYHRGESKLHMCLDIGNGQRKDRK KTSLGPGGSYQISEHAPEASQPAENISKDLYIE VYPGTYSVTVGSNDLTKKTHVVAVDSGQSVDLVF PV*C*PSLPSHHLFLSSKNKATV*FS**LYINP VFSADWVSLPGTGVCLFQCFFVCLVGFFLRQSH SVAQAGVQWRDLGSLQVPPPGFTPFSCLSLPSSW HYRHPPPCPAIFFVFLVETGFHHVGQDGLDLLT S*STHLGLPKCWDYRREPPRPASVPFLT*GCRG PPRLFA*K*YNDAV*TGFTACFPSKG*L***RDL EMKRIHFY*EVKQNVTHVQLGFMGRWQSGCGHI CPKQADPLFHGRGILKQFHQGPGREPQGRIPHS YSPHNRCLPAAYLQGGLRGVEILVVI*LLPVACP LPPSVEEGLVSHSV*LSSNIYHVYSLPIKGGKI PYIVM

Frame 1

LRACALTSEPGEGAP*VAEGVDENGRGGRARPS PGWAPAGVCVGGGPGAVVSREVEAGAPTRIWSR VAAAQLTRRRLYVVCPLREPWTTVWRPQR*MGWT DVPCSVQQGWL*KCWRGPRGGRWTGMPWSVPKA AWGSLPGRRPT*RNSRQPARSAFSRERNIIHLC QRKEGQPMSIVITEASRSCTCAWT*GMVREKTEK RHPLVLEAAIKYQSMLQRHPSLLRTSLRTST*K YIQGPILSLWAQMT*PRRLMW*QLILDKAWTWS SLCDVDHHCHHITFF*VVRIKPLYDSLNSYTLIL FLVLTGSAFRELESVSFSAFLFVWLVFF*DSLT LLPRLECSGVISAHCKFRLPGSHHSPASASRVA GTTGTRHHARLFFLYF**RRGFTMLARMVSIS*P RDPPTLASQSVGITGVSHRARPQCLF*LEGVEV LHACLPESNIMMLSEQVLLLAFQVKVNYDNKEI WK*REFIFIKR*NKMSLMYN*ALWEGGRVAVDTF AQSRLTPSSTEEAS*SSFTRALAGSPRAGSHIP IALTTGAFLLLICREVFVGWRYWWLFDCYLWPV LCLLPLKKALSATLYNSPRIFTMFILYL*KGEKF HTLLC

Frame 2

CAHAP*RVSRVRGLPK*RKG*MKMEGAGALGLV LAGLPLECALGADQERWSPGRSRLGLPPGFGAG SPRPS*PAGVCTLCAHSGSHGQLFGGRSAEWGG PTFPAAFSKAGSRSAGEGQEEGGGLACPGASQRL HGGPCPGGAPPRETAGSRPAARSPGREILFICA RGRRGNPCLSLSQRRVEAAHVLGHREWSEKRQK KDIPWSWRQLSNIRACSRGIPAC*EHL*GPLHRS ISRDLFCHCGLK*LNQEDSCGSS*FWTKRGPGL PCVMLTITAITSPFFK**E*SHCMILLIAIH*S CF*C*LGQPSGNWSLSLSVLFCLFGWFFFETVSL CCPGWSAVA*SRLTASSASRVHTILLPQPPE*L ALQAPATMPGYFFCIFSRDGVSPCWPGWSRSLD LVIHPPWPPKVLGLQA*ATAPGLSAFFNLRV*RS STLVCLKVI**CCLNRFYCLLSK*RLIMIIKRF GNEENSFLLRGETKCHSCTTRLYGKVAEWLWTH LPKAG*PPLPRKRHLKAVSPGPWQGAPGQDPTFL *PSQQVPSCCLSAGRSSWGGDTGGYLTVTCGLS SASFR*RRPCQPLCITLLEYLPCLFFTYKRGKN SIHCYA

Sequence C11orf17.aAug05

GTTGCGCGCATGCGCCTTGACGAGTGAGCCGGGTGAGGGGGCTCCCTAAGTAGCGGAAGGGGTAGATGAAAATGGAAGGGGCGGGCGCGCTAGGCCTAGT CCTGGCTGGGCTCCCGCTGGAGTGTGCGTTGGGGGCGGACCAGGAGCGGTGGTCTCCAGGGAGGTCGAGGCTGGGGCTCCCACCCGGATTTGGAGCAGGG TCGCCGCGGCCCAGCTGACCCGCCGGCGTTTGTACGTTGTGTGCCCACTCAGGGAGCCATGGACAACTGTTTGGCGGCCGCAGCGCTGAATGGGGTGGAC CGACGTTCCCTGCAGCGTTCAGCAAGGCTGGCTCTAGAAGTGCTGGAGAGGGCCAAGAGGAGGGCGGTGGACTGGCATGCCCTGGAGCGTCCCAAAGGCT GCATGGGGGTCCTTGCCCGGGAGGCGCCCCACCTAGAGAAACAGCCGGCAGCCGGCCCGCAGCGCGTTCTCCCGGGAGAGAGAGAAGAGAGACCCCCAAC CCTTAGTGCTTCCTTCAGAACAATGGCTGAATTCATGGACTATACTTCAAGTCAGTGTGGGAAATATTATTCATCTGTGCCAGAGGAAGGAGGGGCAACC CATGTCTATCGTTATCACAGAGGCGAGTCGAAGCTGCACATGTGCTTGGACATAGGGAATGGTCAGAGAAAAGACAGAAAAAAGACATCCCTTGGTCCTG GAGGCAGCTATCAAATATCAGAGCATGCTCCAGAGGCATCCCAGCCTGCTGAGAACATCTCTAAGGACCTCTACATAGAAGTATATCCAGGGACCTATTC TGTCACTGTGGGCTCAAATGACTTAACCAAGAAGACTCATGTGGTAGCAGTTGATTCTGGACAAAGCGTGGACCTGGTCTTCCCTGTGTGATGTTGACCA TCACTGCCATCACATCACCTTTTTTTAAGTAGTAAGAATAAAGCCACTGTATGATTCTCTTAATAGCTATACATTAATCCTGTTTTTAGTGCTGACTGGG TCAGCCTTCCGGGAACTGGAGTCTGTCTCTTTCAGTGCTTTTTTGTTTGTTTGGTTGGTTTTTTTTTGAGACAGTCTCACTCTGTTGCCCAGGCTGGAGT GCAGTGGCGTGATCTCGGCTCACTGCAAGTTCCGCCTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGCACTACAGGCACCCGCCA CCATGCCCGGCTATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACCTCGTGATCCACCCACCTTG GCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTCAGTGCCTTTTTTAACTTGAGGGTGTAGAGGTCCTCCACGCTTGTTTGCCTG AAAGTAATATAATGATGCTGTCTGAACAGGTTTTACTGCTTGCTTTCCAAGTAAAGGTTAATTATGATAATAAAGAGATTTGGAAATGAAGAGAATTCAT TTTTATTAAGAGGTGAAACAAAATGTCACTCATGTACAACTAGGCTTTATGGGAAGGTGGCAGAGTGGCTGTGGACACATTTGCCCAAAGCAGGCTGACC CCCTCTTCCACGGAAGAGGCATCTTAAAGCAGTTTCACCAGGGCCCTGGCAGGGAGCCCCAGGGCAGGATCCCACATTCCTATAGCCCTCACAACAGGTG CCTTCCTGCTGCTTATCTGCAGGGAGGTCTTCGTGGGGTGGAGATACTGGTGGTTATTTGACTGTTACCTGTGGCCTGTCCTCTGCCTCCTTCCGTTGAA GAAGGCCTTGTCAGCCACTCTGTATAACTCTCCTCGAATATTTACCATGTTTATTCTTTACCTATAAAAGGGGGAAAAATTCCATACATTGTTATGCT

C11orf17-F2 (forward primer)
C11orf17-R2 (reverse primer)
Single exon skipping

Frame 0

VARMRLDE*AG*GGSLSSGRGR*KWKGRAR*A* SWLGSRWSVRWGRTRSGGLQGGRGWGSHPDLEQG RRGPADPPAFVRCVPTQGAMDNCLAAAALNGVD RRSLQRSARLALEVLERAKRRAVDWHALERPKG CMGVLAREAPHLEKQPAAGPQRVLPGEREERPPT LSASFRTMAEFMDYTSSQCGKYYSSVPEEGGAT HVYRYHRGESKLHMCLDIGNGQRKDRKKTSLGP GGSYQISEHAPEASQPAENISKDLYIEVYPGTYS VTVGSNDLTKKTHVVAVDSGQSVDLVFPV*C*P SLPSHHLFLSSKNKATV*FS**LYINPVFSADW VSLPGTGVCLFQCFFVCLVGFFLRQSHSVAQAGV QWRDLGSLQVPPPGFTPFSCLSLPSSWHYRHPP PCPAIFFVFLVETGFHHVGQDGLDLLTS*STHL GLPKCWDYRREPPRPASVPFLT*GCRGPPRLFA* K*YNDAV*TGFTACFPSKG*L***RDLEMKRIH FY*EVKQNVTHVQLGFMGRWQSGCGHICPKQAD PLFHGRGILKQFHQGPGREPQGRIPHSYSPHNRC LPAAYLQGGLRGVEILVVI*LLPVACPLPPSVE EGLVSHSV*LSSNIYHVYSLPIKGGKIPYIVM

Frame 1

LRACALTSEPGEGAP*VAEGVDENGRGGRARPS PGWAPAGVCVGGGPGAVVSREVEAGAPTRIWSR VAAAQLTRRRLYVVCPLREPWTTVWRPQR*MGWT DVPCSVQQGWL*KCWRGPRGGRWTGMPWSVPKA AWGSLPGRRPT*RNSRQPARSAFSREREKRDPQ PLVLPSEQWLNSWTILQVSVGNIIHLCQRKEGQP MSIVITEASRSCTCAWT*GMVREKTEKRHPLVL EAAIKYQSMLQRHPSLLRTSLRTST*KYIQGPI LSLWAQMT*PRRLMW*QLILDKAWTWSSLCDVDH HCHHITFF*VVRIKPLYDSLNSYTLILFLVLTG SAFRELESVSFSAFLFVWLVFF*DSLTLLPRLE CSGVISAHCKFRLPGSHHSPASASRVAGTTGTRH HARLFFLYF**RRGFTMLARMVSIS*PRDPPTL ASQSVGITGVSHRARPQCLF*LEGVEVLHACLP ESNIMMLSEQVLLLAFQVKVNYDNKEIWK*REFI FIKR*NKMSLMYN*ALWEGGRVAVDTFAQSRLT PSSTEEAS*SSFTRALAGSPRAGSHIPIALTTG AFLLLICREVFVGWRYWWLFDCYLWPVLCLLPLK KALSATLYNSPRIFTMFILYL*KGEKFHTLLC

Frame 2

CAHAP*RVSRVRGLPK*RKG*MKMEGAGALGLV LAGLPLECALGADQERWSPGRSRLGLPPGFGAG SPRPS*PAGVCTLCAHSGSHGQLFGGRSAEWGG PTFPAAFSKAGSRSAGEGQEEGGGLACPGASQRL HGGPCPGGAPPRETAGSRPAARSPGRERRETPN P*CFLQNNG*IHGLYFKSVWEILFICARGRRGN PCLSLSQRRVEAAHVLGHREWSEKRQKKDIPWSW RQLSNIRACSRGIPAC*EHL*GPLHRSISRDLF CHCGLK*LNQEDSCGSS*FWTKRGPGLPCVMLT ITAITSPFFK**E*SHCMILLIAIH*SCF*C*LG QPSGNWSLSLSVLFCLFGWFFFETVSLCCPGWS AVA*SRLTASSASRVHTILLPQPPE*LALQAPA TMPGYFFCIFSRDGVSPCWPGWSRSLDLVIHPPW PPKVLGLQA*ATAPGLSAFFNLRV*RSSTLVCL KVI**CCLNRFYCLLSK*RLIMIIKRFGNEENS FLLRGETKCHSCTTRLYGKVAEWLWTHLPKAG*P PLPRKRHLKAVSPGPWQGAPGQDPTFL*PSQQV PSCCLSAGRSSWGGDTGGYLTVTCGLSSASFR* RRPCQPLCITLLEYLPCLFFTYKRGKNSIHCYA