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Sequences

Sequence AKAP13.cAug05

GCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTTTGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGA TTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACCACAGCAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAA GACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGGGATACCCAGGAACGTGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAA AAGATGTGAAACTAGATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACATCCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCA GGCAGTAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAATCAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAA AAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCCAGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGGG CAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGGAATACCAGTCTCACAGGACTTGGTGGAGAGCATGAGGGTCCCGCCCC TCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGCAAAGTGTGGGTAAGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAA GAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAAGGATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTT CAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAACAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGC ACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCAGAAACTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAA GGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGTCTGGCCACAGAGTCAAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGC CATGTCTGTTGCCAGATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAGCCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAA AACTAGTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTAATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACAC AACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGCCGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGACC CACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAGCTGGAGGGAGCAGACCACAGCTGTACCATGGGTGACGCTGAGGAAGC CCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGCTCCCCACAGACATGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCT GGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCCCTCTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGG GGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAACAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCA CATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAGAGTGCTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCA ATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCAGGATGTTTTGCTGGAAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGC CAGCAGCAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACT GAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTACAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCAAGCAG AGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTCAAAACAAGGTGTACTTAAAAGAGAATCTGGGAGTGATTCTGACCTCT TTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAAGAGCATTTGGCCTGTGATATCACCGGATCCAGTTCATCCACCGATGA CACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCCAGATTTTAAAGCCAAACAGGTCAAGAGATCGGCAAAGCCTTGATGGA TTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGCTGACCCAGGCGACGTGGAGGAGGAGGAGATGGACAGTATCACTGAAG TGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTCCGGAGGCACAGCTGGGGGCCTGGGAAAAATGCAGCCAGCGATGCAGA AATGAACCACCGGAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGGTGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTCTGCAAATGCCGAA GAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTGTCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAACATAGGATGTTTG ATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTACATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCATTAATGACAATCAG CCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAATACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAACTATAATTTCCTG CCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAAGTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCTAGCAGCAAGAAGA GCAAAGAAAAGGAAAAAGAAAAAGATAAGATTAAGGAGAAGGAGAAAGATTCTAAAGACAAGGAGAAAGATAAGAAGACTGTCAACGGGCACACTTTCAG TTCCATTCCTGTTGTGGGTCCCATCAGCTGTAGCCAGTGTATGAAGCCCTTCACCAACAAAGATGCCTATACTTGTGCAAATTGCAGTGCTTTTGTCCAC AAAGGCTGCCGAGAAAGTCTAGCCTCCTGTGCAAAGGTCAAAATGAAGCAGCCCAAAGGGAGCCTTCAGGCACATGACACATCATCACTGCCCACGGTCA TTATGAGAAACAAGCCCTCACAGCCCAAGGAGCGTCCTCGGTCCGCAGTCCTCCTGGTGGATGAAACCGCTACCACCCCAATATTTGCCAATAGACGATC CCAGCAGAGTGTCTCGCTCTCCAAAAGTGTCTCCATACAGAACATTACTGGAGTTGGCAATGATGAGAACATGTCAAACACCTGGAAATTCCTGTCTCAT TCAACAGACTCACTAAATAAAATCAGCAAGGTCAATGAGTCAACAGAATCACTTACTGATGAGGGTACAGACATGAATGAAGGACAACTACTGGGAGACT TTGAGATTGAGTCCAAACAGCTGGAAGCAGAGTCTTGGAGTCGGATAATAGACAGCAAGTTTCTAAAACAGCAAAAGAAAGATGTGGTCAAACGGCAAGA AGTAATATATGAGTTGATGCAGACAGAGTTTCATCATGTCCGCACTCTCAAGATCATGAGTGGTGTGTACAGCCAGGGGATGATGGCGGATCTGCTTTTT GAGCAGCAGATGGTAGAAAAGCTGTTCCCCTGTTTGGATGAGCTGATCAGTATCCATAGCCAATTCTTCCAGAGGATTCTGGAGCGGAAGAAGGAGTCTC TGGTGGATAAAAGTGAAAAGAACTTTCTCATCAAGAGGATAGGGGATGTGCTTGTAAATCAGTTTTCAGGTGAGAATGCAGAACGTTTAAAGAAGACATA TGGCAAGTTTTGTGGGCAACATAACCAGTCTGTAAACTACTTCAAAGACCTTTATGCCAAGGATAAGCGTTTTCAAGCCTTTGTAAAGAAGAAGATGAGC AGTTCAGTTGTTAGAAGGCTTGGAATTCCAGAGTGCATATTGCTTGTAACTCAGCGGATTACCAAGTACCCAGTTTTATTCCAAAGAATATTGCAGTGTA CCAAAGACAATGAAGTGGAGCAGGAAGATCTAGCACAGTCCTTGAGCCTGGTGAAGGATGTGATTGGAGCTGTAGACAGCAAAGTGGCAAGTTATGAAAA GAAAGTGCGTCTCAATGAGATTTATACAAAGACAGATAGCAAGTCAATCATGAGGATGAAGAGTGGTCAGATGTTTGCCAAGGAAGATTTGAAACGGAAG AAGCTTGTACGTGATGGGAGTGTGTTTCTGAAGAATGCAGCAGGAAGGTTGAAAGAGGTTCAAGCAGTTCTTCTCACTGACATTTTAGTTTTCCTTCAAG AAAAAGACCAGAAGTACATCTTTGCATCATTGGACCAGAAGTCAACAGTGATCTCTTTAAAGAAGCTGATTGTGAGAGAAGTGGCACATGAGGAGAAAGG TTTATTCCTGATCAGCATGGGGATGACAGATCCAGAGATGGTAGAAGTCCATGCCAGCTCCAAAGAGGAACGAAACAGCTGGATTCAGATCATTCAGGAC ACAATCAACACCCTGAACAGAGATGAAGATGAAGGAATTCCTAGTGAGAATGAGGAAGAAAAGAAAATGTTGGACACCAGAGCCCGAGAATTAAAAGAAC AACTTCACCAGAAGGACCAAAAAATCCTACTCTTGTTGGAAGAGAAGGAGATGATTTTCCGGGACATGGCTGAGTGCAGCACCCCTCTCCCAGAGGATTG CTCCCCAACACATAGCCCTAGAGTTCTCTTCCGCTCCAACACAGAAGAGGCTCTCAAAGGAGGACCTTTAATGAAAAGTGCAATAAATGAGGTGGAGATC CTTCAGGGTTTGGTGAGTGGAAATCTGGGAGGCACACTTGGGCCGACTGTCAGCAGCCCCATTGAGCAAGATGTGGTCGGTCCCGTTTCCCTGCCCCGGA GAGCAGAGACCTTTGGAGGATTTGACAGCCATCAGATGAATGCTTCAAAAGGAGGCGAGAAGGAAGAGGGAGATGATGGCCAAGATCTTAGGAGAACGGA ATCAGATAGTGGCCTAAAAAAGGGTGGAAATGCTAACCTGGTATTTATGCTTAAAAGAAACAGTGAGCAGGTTGTCCAGAGCGTTGTTCATCTCTACGAG CTCCTCAGCGCTCTGCAGGGTGTGGTGCTGCAGCAGGACAGCTACATTGAGGACCAGAAACTGGTGCTGAGCGAGAGGGCGCTCACTCGCAGCTTGTCCC GCCCGAGCTCCCTCATTGAGCAGGAGAAGCAGCGCAGCCTGGAGAAGCAGCGCCAGGACCTGGCCAACCTGCAGAAGCAGCAGGCCCAGTACCTCGAGGA GAAGCGCAGGCGCGAGCGTGAGTGGGAAGCTCGTGAGAGGGAGCTGCGGGAGCGGGAGGCCCTCCTGGCCCAGCGCGAGGAGGAGGTGCAGCAGGGGCAG CAGGACCTGGAAAAGGAGCGGGAGGAGCTCCAGCAGAAGAAGGGCACATACCAGTATGACCTGGAGCGACTGCGTGCTGCCCAGAAACAGCTTGAGAGGG AACAGGAGCAGCTGCGCCGGGAGGCAGAGCGGCTCAGCCAGCGGCAGACAGAACGGGACCTGTGTCAGGTTTCCCATCCACATACCAAGCTGATGAGGAT CCCATCGTTCTTCCCCAGTCCTGAGGAGCCCCCCTCGCCATCTGCACCTTCCATAGCCAAATCAGGGTCATTGGACTCAGAACTTTCAGTGTCCCCAAAA AGGAACAGCATCTCTCGGACACACAAAGATAAGGGGCCTTTTCACATACTGAGTTCAACCAGCCAGACAAACAAAGGACCAGAAGGGCAGAGCCAGGCCC CTGCGTCCACCTCTGCCTCTACCCGCCTGTTTGGGTTAACAAAGCCAAAGGAAAAGAAGGAGAAAAAAAAGAAGAACAAAACCAGCCGCTCTCAGCCCGG TGATGGTCCCGCGTCAGAAGTATCAGCAGAGGGTGAAGAGATCTTCTGCTGACCCTCTTCCTCTCTGCTGAGGCAGCTGCCTCCTGATCCTGGCCAGCCC ACCTCTCCTGCTGTCCCCGCGTGCACAAGTCTCTTACACTGGACGCCCACTGCTCCTCAGCGTCCAGTCCTCCTGGGCGGCCCCAGGTCCTGGACAATAA GCAACAGATGATATTGAGTGTCGGGTGGGGAAGGAGGCCCAGACTCTGCTTCGGCCATGATTTGTGACTGCCCAGGACTCTCAGGTTGGGCTGGCCCTAC TCAGGATTACACTGAAAGTAATGGCCTCGTAAGTACAGGTGATGGTTTTGGACACGTCAGGAATTCCTAAAGGCTGAAAGAGTGTATCCAAGTAAGGTCT GAACCTCCGAATGCCTTTTATTTGGGGGAACACAAAACCAAACAGCAGATGTTTTGGACTTGATCTGTGTACGTACATGGGGACCTGTCTGCATATACAC ACGGGGAATGCCAGAAGAAGGCCCAGTCTGCACCAGGCGTCTGGTCAACTTAGCACAAGGGCAGTGCCTGGACGGACCCGGAGCCCCCGCATATCAGCAG TTCACCCAGTACTCCTCAGAGACTGGTTTCCCTCTAAACCCATCCCGGGCACATACCACCCGTGTTTTGCATGTATTTCTCATTTCATTTTAGGGATGAC AAACATTTGTGAAACCAGTGAGAGAAGGCTTGATGTGTATAAAAGACGTGATGTGCACCACCTCGATCTCGGTGTTTCAGGCACTAAAGCAACAAAACAA CCCATAGTATCTCATTCTGTCATCAGATCCAGAAGAAATATCCTGGTTTTCCAGCATGTTTACCCACATGTTTTGGCCATGGATAAAGTGAAGAGGCCTA CTCACCATTATCCCTGCAGCGTGACACCTTTTGATTGTCACTGACCACTCAGAAGGGGCCACGGCCTCCTGGCTGTGTTCCTGAGCCCCCGTCGTGCCTC TCCCAGACAGCAGCTGTCTGGCCCTTGCTGGGTGAGGGCACACCACTGCCAGGGGTCAGCCTCGCACCCAGGCCAGGCAGAAGCTGTGCTCTGAAGCTAG GACAGCTGGCTGAGAAGTGGGTTCAGGCGAAGGGTGAAGCCATGTGTAGCAGTTCCTGCCAGTGCAGATCTGGAGAGGAGCTGGCCCGGAAGGCGTGGTT GTGAAAGCGCCCTTCTTATGTTAGGAGGCCTTGGCAAAATTGGATTTCTTCAAAAATACATGTAAAGGTCTGTTGTTGAATTGTACTCTGCCCCTGGAAG CAGATACAGATGGCTGCCTGCTGCTCGGCTTTGCTTTTGCTTTTCCCACCGTGTTTTCATCTTTGTTCACTTGAGGCTTTCCCCAGCTGGTGTGTGCAGG ACAGTTCATGGTAATGTTGCCCTCTGAGGCCCCGTACACCAGAAGGGAGGCCCTGGAAAATTTTGTGCTTCCAACGTGGCCTTCAATTCTTGCTTTTTTG CCCCTCGGAAGCATGGGGCTTTTGAGCACACTTAAAAAAAGAAAAATCTGTAACTTGGTGCTTATTGATGAATTGCAAGCTGGCCTTGCAGATGGAGATA TTTATCTTTCAGTTTATTTGAAAGAGGTCTGGTTTAAAATTTGTAGCCTACATTTGTTTTATTTATTGTATTTGTGTGTTTGTGTTTGTTTTTTTTTAAG GGTGAGCCAGGTCTAGCCCAACAGTCTAAACTATCCAGTCAATACCGAGTGAAGTGGCAGCCAGCACTGTTCACTCTGTGTCTTTTGAAGTGCCTTGAAG GCCCAGATGAAATTTTAAAGGGAGGGGGTCCATGTCCTTCCCTCCCCCACCCCGCCTCATTCTTTAATCAAAGGATGTCTTCTCCCTTGTTTGAGAATGA AGAAACTCGCCACCTCTGACCTACCTTTGCCTTTTTCTGTCATGGAGAATACTCACCCTTCAGAAACAGACCAAAGGCCAAAACCTGCTGATTTTTCTAT TGAAAATATGTCCCCTTGCAAAGACCCTAAACAAAAAGTTAAGTTTCTTTCTTTCACCTATTTGTACAACTCCAAGTTACAGCTGAATCTGTCGTGACTT TCCTGAGATCTACCCGGGGCTTGGCTGTCTGTTCTGGGCACTGGCTCCGAGTTCCCCTCCTGGGATTTGCAGGAGGGCAGTACTGAACCTGCATTCTTCT CCTTGTAAATGTAGGCCGGGTGCCCCTGTTCTCCGGGTTTGGAACAATACGAGGTTGGTGCTGATGGGATTTACTTGCGTACGTGCTCTTCACAAAAACA CCGTGGATGCTGAAGTTAGAGCACGTCGCCACAGAGCTTGACATCAATGTTAGAGGGTCTCTTACTCCCCGCCCAGCTGTGATGTTTCATCTGCTTTGGT TGTTTTGGTGGTCTTTTTTAAAAATAGAGATTTCACATCTGCCCAGACCCCACTCAAAACGATTTGGTCAGGTTCTGGTTGGACAAGTTTAAAATCAAAG TAGTGCCCGGAATTCCCTCAAACCACCCAACTTCATCCAGGAATACAGTCTGCAGTGCAGCAACAGAACCGCTTACCAAGAACTGTGCTTACATACCTTT GTCATCTCTCTTCCCCCCTTGGAAGTTGTCCTCAGGGGGATTTGTTCCTGTCCTGGGGATTTACCTGGGATGGTGGCTGCCTGTGCTTTTGCTCATGGCC TTGACAGTGCTCTAGTTGCTGGATCTAATGGCCTGTCTTGGTTTCTATCACATGAGAAGGGGTTGTTTTTTTGGGGTGACTCGGACTGAATTCCCCATAC TGTTTCCACGCCGGGACACCATGTTCTCCATCAAGCTAAAGAAATCACGTGCCTGAAACTGTGCTTAAGTTTTGGGGGAAAGATGGAGTTCCTATCCAGA GCCCCCAGATTTCCAGAATCGAGTGAGCTTCCTGGAAGGAGACTGCGTCTTCTCTCAATTCCAGTCATCTCAGTCGTTGTCGTTAGGTGACATGTGCACT TTAAATGCTCTCATCGGTTGGCTTCATTTTCAAGACAATCAAATGTATTGACTGTGTTTTCTTCTTAGAAAATGGAGAGGGTTAAAAACATGCAAACTGC CACTTTCAACCTTTGCCAGTATTCCCTCTACCCCCGTGAGAGCTATCTGGGGGGAAGAATCCTTACCAAGGTTTTTTTGGAAAGGTACGAATCTTAACTT TTTTCCCCTTCTGTGTCTCAGGGTAATACTATTCAGAGTCGCCCCTTTGCTCATTTTCTCCCGTATTTGTTACCTTCCTGAGGCCTCAGTATTAGTCGTG AGCACAAAGTTTTGAGACCTTTGGCGTTGTTTCTTGATGTGGGAGGGGAGGTGTTAGTGCATGCAAGGGTTGAACTAGATAGACCCTGCCTTAGTAGAGG GTGGGACTATAACCTTAGAGGCCAGAACTTGATCCAGAAGTTGCTGTCCACAGAAGTGCTTTCTATTTCATCATTTTTGTTTCTAGGGCTCTTTTTCTGT AGCCAGGTCTTCCCAAGGATTTTAGTATTTGCATTGGAGTTGAGGTTTACTCTAATGATGGTGGCCCAGCTGTGCCCAGAGGACAGCCAGGCAGGCCCTG GGAGGGAGTTTAGAAAGACAGTCCTGGTGAATGGGCTTCAAGTGGTCACAAAGAGGGTGGCTGTGAGGTGACCCCAGACACTGCAGAACGATGTGCACCC TCTGCGTTTTGGATGTCCTTGGAATGTGGGAGCCTAGAAATAACCCTGTGGATGGAATTGGGGCAGCGGCTGCTGGAGATCTGTGTGCCTTGCCTTCCTT CAGCAGGACCGTCTAGGTGCGCAGCCACCTATGGATGCGTCCCAGCCAGCCCCGTCGCTCTCGTCCATCCTCAGAGACAAAGAAGAGGGCAGGGAGTTTG GGCTTGGTTTTGAACTTTCCTTTCAATGTAGCAAAGCATTCCTAGTTAACCAGAGCCTTGGAATCTACTGCCTGCTGGCCAGGCTTTAAAATGAAAAGTG TTTTAATGCTGCCATAAAAGGGAGGCGGGGGGGAGGAAGGGAAAATAAAGGCATCTTTCCAAGTACTCATCTAATTTAATTGTCAAAAGATTGATAGGCC ATGAATTACTTCTCCATCTCACTAAGGGTTAAAGGCGTGCAACCCCCCACTGGCTGTGTCCCCTGCCACCGAAGTGAGTGACCTGCCCTACAACCAGGTG GGACCACCTGTGCTGCAGTCCGGAGGGGCTTCTGCAGGAAGCACTCACCCCCCACACCTTCCCCGGCCTGAGCTTCCCCTACCTTTCGTCACCACCTGAG GGCATGAGCACAGGCCATGGGGCGTGCCTGGTGAGTCTGCCTGTGGTTCAGGCTTAGCCTGTGGTCTCCTGTGTGCTGCTGCCCGCATGGGATGCGCAGG GGAGGCGTGGGGATCCGCAGGAGGGTGGTTGGGATACACCGGATACCTCTGCTCTCATTGCTTGTTTGCAAATGCTCTATGGACATTTGTGTGCTAAATC CTATTAAATAAAAAAGACGGGTTAAAACCCAGATGCTGTATATTCATTTGTAATTATGTATAAAGTGAAGCAGTTTTAAACTGTAAAGATTTTTTTCAGT GTGTTTTCTCGAATTTTGCCACAACATACTGGCTTCGTATTTTATTTATCTTTCTTTCTAGTTACCAGCTTCAGACCCTTGTAAAGTCTCCCTCAGCCCT TTCAAAAAATAATAAATTTCCTGTGAAGTTCTGG

AKAP13-F1 (forward primer)
AKAP13-R1 (reverse primer)
Single exon skipping

Sequence Tools

Translations

Frame 0

AKRANPHPFVLQLETINFVQTLHVNRTQ*LLVA IWLQNCVIT*LASPKAPQQGNPAHKIHPMPPTVK THRLIQSPLTL*GIPRNVRIFVLSKWWITKANE KM*N*INL*QICLRWFHIHIQLSLKWRKNWCQT RQ*YQTVLSLWQTVQAVNQ*PRMTHFLLSPPRKK REQQLLNYIQLQIIEMAQMEIRMSLIRGH*KTG Q*ACPHPPLLQSFSTGWGIPVSQDLVESMRVPP LQQSQKL*ISRGTLTLPCKVWVRPLWL*IQF*LK KENFWWFQKALQLRNKIRIKR*PVPLLRKMLSL QELCRKSREHHLLDKILNNFMKNQSQLTVPRTK HFS*VIHRVHPLPFLRQKLNITRKWPHKSHC*LK VGLPRAWCHQEQVWPQSQGRKPWGQSTTAPLCC HVCCQMGLMGPMLLTAVSLLLWMLE*RTLNPRE KLVPVR*VEM*RWMLQGLMLYKVWLSPEERIYHT TPKTS*FQTSC*AKRRMPF*VCQWLYRTKL*LT HRELEPQR*YLLIGRKGSWREQTTAVPWVTLRK PK*TMKHILSYCSLLPRSSPQTWSSQPMMMGPQL V*GKSCEPRLQAGKGALPLYLAWSLPRTHLCLR GQT**RRLPAV*WMLSSNKSRPLEHCLLRGRPV TCHCPALSWVLSLKD*RVLLQKK*VLSHLGRAYQ WAVLLRKPRGALQDVLLEGRSQRRSFYLSRGLS QQQKCQT*KLKMKWILEQVQFLKKWL*GA*LLH *R*SKAQ*PRR*TEKTGVQ*SHALMQHLFWLPSR AQNVRTSWMLDWAESVPQNKVYLKENLGVILTS FTHPVMTWTASSSQSQRKSIWPVISPDPVHPPM TRLHWTDILLMAVMCLSPRF*SQTGQEIGKALMD STAMGWELRVEKVRVSLLTQATWRRRRWTVSLK CLQTALS*GAPCALFLPSGGTAGGLGKMQPAMQ K*TTGVSV*KA*QEELVSETSHPHL*K*ALQMPK SSDTHSVVRNGLTLWCHFQKRIWSQTRENIGCL ISRYVTDLSSRDLITVHQPFPLH*QNPSH**QS AILDWTIHGPSTVPSTIPVLI*LRV*QKRTIISC HIAPPRKILNGRVEQKSVVHSATSRIKCLAARR AKKRKKKKIRLRRRRKILKTRRKIRRLSTGTLS VPFLLWVPSAVASV*SPSPTKMPILVQIAVLLST KAAEKV*PPVQRSK*SSPKGAFRHMTHHHCPRS L*ETSPHSPRSVLGPQSSWWMKPLPPQYLPIDD PSRVSRSPKVSPYRTLLELAMMRTCQTPGNSCLI QQTH*IKSARSMSQQNHLLMRVQT*MKDNYWET LRLSPNSWKQSLGVG**TASF*NSKRKMWSNGK K*YMS*CRQSFIMSALSRS*VVCTARG*WRICFL SSRW*KSCSPVWMS*SVSIANSSRGFWSGRRSL WWIKVKRTFSSRG*GMCL*ISFQVRMQNV*RRH MASFVGNITSL*TTSKTFMPRISVFKPL*RRR*A VQLLEGLEFQSAYCL*LSGLPSTQFYSKEYCSV PKTMKWSRKI*HSP*AW*RM*LEL*TAKWQVMK RKCVSMRFIQRQIASQS*G*RVVRCLPRKI*NGR SLYVMGVCF*RMQQEG*KRFKQFFSLTF*FSFK KKTRSTSLHHWTRSQQ*SL*RS*L*EKWHMRRK VYS*SAWG*QIQRW*KSMPAPKRNETAGFRSFRT QSTP*TEMKMKEFLVRMRKKRKCWTPEPEN*KN NFTRRTKKSYSCWKRRR*FSGTWLSAAPLSQRI APQHIALEFSSAPTQKRLSKEDL**KVQ*MRWRS FRVW*VEIWEAHLGRLSAAPLSKMWSVPFPCPG EQRPLEDLTAIR*MLQKEARRKREMMAKILGER NQIVA*KRVEMLTWYLCLKETVSRLSRALFISTS SSALCRVWCCSRTATLRTRNWC*ARGRSLAACP ARAPSLSRRSSAAWRSSARTWPTCRSSRPSTSR RSAGASVSGKLVRGSCGSGRPSWPSARRRCSRGS RTWKRSGRSSSRRRAHTSMTWSDCVLPRNSLRG NRSSCAGRQSGSASGRQNGTCVRFPIHIPS**G SHRSSPVLRSPPRHLHLP*PNQGHWTQNFQCPQK GTASLGHTKIRGLFTY*VQPARQTKDQKGRARP LRPPLPLPACLG*QSQRKRRRKKRRTKPAALSP VMVPRQKYQQRVKRSSADPLPLC*GSCLLILASP PLLLSPRAQVSYTGRPLLLSVQSSWAAPGPGQ* ATDDIECRVGKEAQTLLRP*FVTAQDSQVGLAL LRITLKVMAS*VQVMVLDTSGIPKG*KSVSK*GL NLRMPFIWGNTKPNSRCFGLDLCTYMGTCLHIH TGNARRRPSLHQASGQLSTRAVPGRTRSPRISA VHPVLLRDWFPSKPIPGTYHPCFACISHFILGMT NICETSERRLDVYKRRDVHHLDLGVSGTKATKQ PIVSHSVIRSRRNILVFQHVYPHVLAMDKVKRP THHYPCSVTPFDCH*PLRRGHGLLAVFLSPRRAS PRQQLSGPCWVRAHHCQGSASHPGQAEAVL*S* DSWLRSGFRRRVKPCVAVPASADLERSWPGRRG CESALLMLGGLGKIGFLQKYM*RSVVELYSAPGS RYRWLPAARLCFCFSHRVFIFVHLRLSPAGVCR TVHGNVAL*GPVHQKGGPGKFCASNVAFNSCFF APRKHGAFEHT*KKKNL*LGAY**IASWPCRWRY LSFSLFERGLV*NL*PTFVLFIVFVCLCLFFFK GEPGLAQQSKLSSQYRVKWQPALFTLCLLKCLE GPDEILKGGGPCPSLPHPASFFNQRMSSPLFENE ETRHL*PTFAFFCHGEYSPFRNRPKAKTC*FFY *KYVPLQRP*TKS*VSFFHLFVQLQVTAESVVT FLRSTRGLAVCSGHWLRVPLLGFAGGQY*TCILL LVNVGRVPLFSGFGTIRGWC*WDLLAYVLFTKT PWMLKLEHVATELDINVRGSLTPRPAVMFHLLW LFWWSFLKIEISHLPRPHSKRFGQVLVGQV*NQS SARNSLKPPNFIQEYSLQCSNRTAYQELCLHTF VISLPPLEVVLRGICSCPGDLPGMVAACAFAHG LDSALVAGSNGLSWFLSHEKGLFFWGDSD*IPHT VSTPGHHVLHQAKEITCLKLCLSFGGKMEFLSR APRFPESSELPGRRLRLLSIPVISVVVVR*HVH FKCSHRLASFSRQSNVLTVFSS*KMERVKNMQTA TFNLCQYSLYPRESYLGGRILTKVFLERYES*L FSPSVSQGNTIQSRPFAHFLPYLLPS*GLSISR EHKVLRPLALFLDVGGEVLVHARVELDRPCLSRG WDYNLRGQNLIQKLLSTEVLSISSFLFLGLFFC SQVFPRILVFALELRFTLMMVAQLCPEDSQAGP GREFRKTVLVNGLQVVTKRVAVR*PQTLQNDVHP LRFGCPWNVGA*K*PCGWNWGSGCWRSVCLAFL QQDRLGAQPPMDASQPAPSLSSILRDKEEGREF GLGFELSFQCSKAFLVNQSLGIYCLLARL*NEKC FNAAIKGRRGGGRENKGIFPSTHLI*LSKD**A MNYFSISLRVKGVQPPTGCVPCHRSE*PALQPG GTTCAAVRRGFCRKHSPPTPSPA*ASPTFRHHLR A*AQAMGRAW*VCLWFRLSLWSPVCCCPHGMRR GGVGIRRRVVGIHRIPLLSLLVCKCSMDICVLN PIK*KRRVKTQMLYIHL*LCIK*SSFKL*RFFSV CFLEFCHNILASYFIYLSF*LPASDPCKVSLSP FKK**ISCEVL

Frame 1

PKGQILTHLFYNWRR*TLCRLCMSTEHSDF*WR FGCKTV**HS*RVRKHHSKATQLTRSTRCLPL* RPTGSYSHL*PCKGYPGTCGFLSFQSGG*QRPTK RCETR*TFNKYA*GGFTSTSSCP*NGERTGARP GSNIRQYFLSGKQSRQ*ISNQG*RTFFCPLPER KGNSNS*TTYSYRL*RWPRWKFE*A*YAATRRQG SRPVHILHCCRASARDGEYQSHRTWWRA*GSRP SSNPRSSEYQGEH*LFPAKCG*GHFGFRFSFD* RRKTSGGFRKLCSSGTR*G*SGDLFLY*GKCSLF RNFAGRAENTTSWTRYSTIS*KINLS*LCQGQS TSAK*FTGCILCLS*GRN*T*QGSGPTSLTADS RWGCPEPGATRSKSGHRVKAGSLGGRAQQLRSVA MSVARWV*WVRCS*LQSAFSSGCWSEEHSIPGK N*CL*GEWRCDGGCYRG*CSTRYG*AQKREYIT QHPRHPDSKRLVEPREECRSRFASGSTGQSCD*P TGSWNPRDDTS*LGEREAGGSRPQLYHG*R*GS PNRR*STSCPTAACCQGAPHRHGALSP**WGPS WCEGSHASPAFRQGKEHSLSTLHGLCPGRTSA*G GRLDRGGCQPYSGCCHRTSQGRWSTAY*GGGLS HVTVQP*VGSSH*RTRECFYRKSEYFPTWGEPT NGQYS*GSHGEPCRMFCWKGGAREDHFTCPGA*A SSRNARRES*R*SGF*SKFNF*RSGCREHSCYT EDEARPNDPGDKPRKLVYNRAMP*CSISSGFQA EPRM*ELPGCWTGQRVYLKTRCT*KRIWE*F*PL SLTQ**HGQHHLPKARGRAFGL*YHRIQFIHR* HGFTGPTFFSWQ*CVSLPDFKAKQVKRSAKP*W ILQPWDGS*GSRK*E*AC*PRRRGGGGDGQYH*S ACKLLCPKELHALSFSLPEAQLGAWEKCSQRCR NEPPEFQSRRLDRRSWCRKQAILISRSKLCKCR RAQTPIQW*GTG*LFGVTFRRGSGVRPERT*DV* SADMSQI*AAGI*LLYISHFLSIDKIHLINDNQ PSWIGQFTALPQYLPQYQC*SD*EYNRREL*FP AT*PLQERF*MEEWNKSQSYIQLHQE*NV*QQEE QRKGKRKR*D*GEGERF*RQGER*EDCQRAHFQ FHSCCGSHQL*PVYEALHQQRCLYLCKLQCFCP QRLPRKSSLLCKGQNEAAQREPSGT*HIITAHGH YEKQALTAQGASSVRSPPGG*NRYHPNICQ*TI PAECLALQKCLHTEHYWSWQ**EHVKHLEIPVS FNRLTK*NQQGQ*VNRITY**GYRHE*RTTTGRL *D*VQTAGSRVLESDNRQQVSKTAKERCGQTAR SNI*VDADRVSSCPHSQDHEWCVQPGDDGGSAF *AADGRKAVPLFG*ADQYP*PILPEDSGAEEGVS GG*K*KELSHQEDRGCACKSVFR*ECRTFKEDI WQVLWAT*PVCKLLQRPLCQG*AFSSLCKEEDE QFSC*KAWNSRVHIACNSADYQVPSFIPKNIAVY QRQ*SGAGRSSTVLEPGEGCDWSCRQQSGKL*K ESASQ*DLYKDR*QVNHEDEEWSDVCQGRFETE EACT*WECVSEECSRKVERGSSSSSH*HFSFPSR KRPEVHLCIIGPEVNSDLFKEADCERSGT*GER FIPDQHGDDRSRDGRSPCQLQRGTKQLDSDHSG HNQHPEQR*R*RNS**E*GRKENVGHQSPRIKRT TSPEGPKNPTLVGREGDDFPGHG*VQHPSPRGL LPNT*P*SSLPLQHRRGSQRRTFNEKCNK*GGD PSGFGEWKSGRHTWADCQQPH*ARCGRSRFPAPE SRDLWRI*QPSDECFKRRREGRGR*WPRS*ENG IR*WPKKGWKC*PGIYA*KKQ*AGCPERCSSLR APQRSAGCGAAAGQLH*GPETGAEREGAHSQLVP PELPH*AGEAAQPGEAAPGPGQPAEAAGPVPRG EAQARA*VGSS*EGAAGAGGPPGPARGGGAAGA AGPGKGAGGAPAEEGHIPV*PGATACCPETA*EG TGAAAPGGRAAQPAADRTGPVSGFPSTYQADED PIVLPQS*GAPLAICTFHSQIRVIGLRTFSVPK KEQHLSDTQR*GAFSHTEFNQPDKQRTRRAEPGP CVHLCLYPPVWVNKAKGKEGEKKEEQNQPLSAR *WSRVRSISRG*RDLLLTLFLSAEAAAS*SWPA HLSCCPRVHKSLTLDAHCSSASSPPGRPQVLDNK QQMILSVGWGRRPRLCFGHDL*LPRTLRLGWPY SGLH*K*WPRKYR*WFWTRQEFLKAERVYPSKV *TSECLLFGGTQNQTADVLDLICVRTWGPVCIYT RGMPEEGPVCTRRLVNLAQGQCLDGPGAPAYQQ FTQYSSETGFPLNPSRAHTTRVLHVFLISF*G* QTFVKPVREGLMCIKDVMCTTSISVFQALKQQNN P*YLILSSDPEEISWFSSMFTHMFWPWIK*RGL LTIIPAA*HLLIVTDHSEGATASWLCS*APVVP LPDSSCLALAG*GHTTARGQPRTQARQKLCSEAR TAG*EVGSGEG*SHV*QFLPVQIWRGAGPEGVV VKAPFLC*EALAKLDFFKNTCKGLLLNCTLPLE ADTDGCLLLGFAFAFPTVFSSLFT*GFPQLVCAG QFMVMLPSEAPYTRREALENFVLPTWPSILAFL PLGSMGLLSTLKKRKICNLVLIDELQAGLADGD IYLSVYLKEVWFKICSLHLFYLLYLCVCVCFFLR VSQV*PNSLNYPVNTE*SGSQHCSLCVF*SALK AQMKF*REGVHVLPSPTPPHSLIKGCLLPCLRM KKLATSDLPLPFSVMENTHPSETDQRPKPADFSI ENMSPCKDPKQKVKFLSFTYLYNSKLQLNLS*L S*DLPGAWLSVLGTGSEFPSWDLQEGSTEPAFF SL*M*AGCPCSPGLEQYEVGADGIYLRTCSSQKH RGC*S*STSPQSLTSMLEGLLLPAQL*CFICFG CFGGLF*K*RFHICPDPTQNDLVRFWLDKFKIK VVPGIPSNHPTSSRNTVCSAATEPLTKNCAYIPL SSLFPPWKLSSGGFVPVLGIYLGWWLPVLLLMA LTVL*LLDLMACLGFYHMRRGCFFGVTRTEFPI LFPRRDTMFSIKLKKSRA*NCA*VLGERWSSYPE PPDFQNRVSFLEGDCVFSQFQSSQSLSLGDMCT LNALIGWLHFQDNQMY*LCFLLRKWRGLKTCKL PLSTFASIPSTPVRAIWGEESLPRFFWKGTNLNF FPLLCLRVILFRVAPLLIFSRICYLPEASVLVV STKF*DLWRCFLMWEGRC*CMQGLN*IDPALVE GGTITLEART*SRSCCPQKCFLFHHFCF*GSFSV ARSSQGF*YLHWS*GLL**WWPSCAQRTARQAL GGSLERQSW*MGFKWSQRGWL*GDPRHCRTMCT LCVLDVLGMWEPRNNPVDGIGAAAAGDLCALPSF SRTV*VRSHLWMRPSQPRRSRPSSETKKRAGSL GLVLNFPFNVAKHS*LTRALESTACWPGFKMKS VLMLP*KGGGGEEGKIKASFQVLI*FNCQKIDRP *ITSPSH*GLKACNPPLAVSPATEVSDLPYNQV GPPVLQSGGASAGSTHPPHLPRPELPLPFVTT* GHEHRPWGVPGESACGSGLACGLLCAAARMGCAG EAWGSAGGWLGYTGYLCSHCLFANALWTFVC*I LLNKKDGLKPRCCIFICNYV*SEAVLNCKDFFQ CVFSNFATTYWLRILFIFLSSYQLQTLVKSPSAL SKNNKFPVKFW

Frame 2

QKGKSSPICSTTGDDKLCADSACQQNTVTSSGD LVAKLCDNIVSESESTTARQPSSQDPPDASHCE DPQAHTVTSDPVRDTQERADFCPFKVVDNKGQR KDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQ AVISDSTFSLANSPGSESVTKDDALSFVPSQKE KGTATPELHTATDYRDGPDGNSNEPDTRPLEDR AVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAP PAIPEALNIKGNTDSSLQSVGKATLALDSVLTE EGKLLVVSESSAAQEQDKDKAVTCSSIKENALS SGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKA LQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQ GGAAQSLVPPGASLATESRQEALGAEHNSSALL PCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGK TSACEVSGDVTVDVTGVNALQGMAEPRRENISH NTQDILIPNVLLSQEKNAVLGLPVALQDKAVTD PQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEA QIDDEAHPVLLQPVAKELPTDMELSAHDDGAPA GVREVMRAPPSGRERSTPSLPCMVSAQDAPLPK GADLIEEAASRIVDAVIEQVKAAGALLTEGEACH MSLSSPELGPLTKGLESAFTEKVSTFPPGESLP MGSTPEEATGSLAGCFAGREEPEKIILPVQGPE PAAEMPDVKAEDEVDFRASSISEEVAVGSIAATL KMKQGPMTQAINRENWCTIEPCPDAASLLASKQ SPECENFLDVGLGRECTSKQGVLKRESGSDSDL FHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDD TASLDRHSSHGSDVSLSQILKPNRSRDRQSLDG FYSHGMGAEGRESESEPADPGDVEEEEMDSITE VPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAE MNHRSFSLEGLTGGAGVGNKPSSSLEVSSANAE ELRHPFSGEERVDSLVSLSEEDLESDQREHRMF DQQICHRSKQQGFNYCTSAISSPLTKSISLMTIS HPGLDNSRPFHSTFHNTSANLTESITEENYNFL PHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKK SKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFS SIPVVGPISCSQCMKPFTNKDAYTCANCSAFVH KGCRESLASCAKVKMKQPKGSLQAHDTSSLPTV IMRNKPSQPKERPRSAVLLVDETATTPIFANRRS QQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH STDSLNKISKVNESTESLTDEGTDMNEGQLLGD FEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQE VIYELMQTEFHHVRTLKIMSGVYSQGMMADLLF EQQMVEKLFPCLDELISIHSQFFQRILERKKES LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTY GKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMS SSVVRRLGIPECILLVTQRITKYPVLFQRILQC TKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEK KVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRK KLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ EKDQKYIFASLDQKSTVISLKKLIVREVAHEEKG LFLISMGMTDPEMVEVHASSKEERNSWIQIIQD TINTLNRDEDEGIPSENEEEKKMLDTRARELKE QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDC SPTHSPRVLFRSNTEEALKGGPLMKSAINEVEI LQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPR RAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTE SDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYE LLSALQGVVLQQDSYIEDQKLVLSERALTRSLS RPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEE KRRREREWEARERELREREALLAQREEEVQQGQ QDLEKEREELQQKKGTYQYDLERLRAAQKQLER EQEQLRREAERLSQRQTERDLCQVSHPHTKLMRI PSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPK RNSISRTHKDKGPFHILSSTSQTNKGPEGQSQA PASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPG DGPASEVSAEGEEIFC*PSSSLLRQLPPDPGQP TSPAVPACTSLLHWTPTAPQRPVLLGGPRSWTI SNR*Y*VSGGEGGPDSASAMICDCPGLSGWAGPT QDYTESNGLVSTGDGFGHVRNS*RLKECIQVRS EPPNAFYLGEHKTKQQMFWT*SVYVHGDLSAYT HGECQKKAQSAPGVWST*HKGSAWTDPEPPHISS SPSTPQRLVSL*THPGHIPPVFCMYFSFHFRDD KHL*NQ*EKA*CV*KT*CAPPRSRCFRH*SNKT THSISFCHQIQKKYPGFPACLPTCFGHG*SEEAY SPLSLQRDTF*LSLTTQKGPRPPGCVPEPPSCL SQTAAVWPLLGEGTPLPGVSLAPRPGRSCALKL GQLAEKWVQAKGEAMCSSSCQCRSGEELARKAWL *KRPSYVRRPWQNWISSKIHVKVCC*IVLCPWK QIQMAACCSALLLLFPPCFHLCSLEAFPSWCVQ DSSW*CCPLRPRTPEGRPWKILCFQRGLQFLLFC PSEAWGF*AHLKKEKSVTWCLLMNCKLALQMEI FIFQFI*KRSGLKFVAYICFIYCICVFVFVFF* G*ARSSPTV*TIQSIPSEVAASTVHSVSFEVP*R PR*NFKGRGSMSFPPPPRLIL*SKDVFSLV*E* RNSPPLTYLCLFLSWRILTLQKQTKGQNLLIFL LKICPLAKTLNKKLSFFLSPICTTPSYS*ICRDF PEIYPGLGCLFWALAPSSPPGICRRAVLNLHSS PCKCRPGAPVLRVWNNTRLVLMGFTCVRALHKN TVDAEVRARRHRA*HQC*RVSYSPPSCDVSSALV VLVVFFKNRDFTSAQTPLKTIWSGSGWTSLKSK *CPEFPQTTQLHPGIQSAVQQQNRLPRTVLTYL CHLSSPLGSCPQGDLFLSWGFTWDGGCLCFCSWP *QCSSCWI*WPVLVSIT*EGVVFLG*LGLNSPY CFHAGTPCSPSS*RNHVPETVLKFWGKDGVPIQ SPQISRIE*ASWKETASSLNSSHLSRCR*VTCAL *MLSSVGFIFKTIKCIDCVFFLENGEG*KHANC HFQPLPVFPLPP*ELSGGKNPYQGFFGKVRILT FFPFCVSG*YYSESPLCSFSPVFVTFLRPQY*S* AQSFETFGVVS*CGRGGVSACKG*TR*TLP**R VGL*P*RPELDPEVAVHRSAFYFIIFVSRALFL *PGLPKDFSICIGVEVYSNDGGPAVPRGQPGRPW EGV*KDSPGEWASSGHKEGGCEVTPDTAERCAP SAFWMSLECGSLEITLWMELGQRLLEICVPCLP SAGPSRCAATYGCVPASPVALVHPQRQRRGQGVW AWF*TFLSM*QSIPS*PEPWNLLPAGQALK*KV F*CCHKREAGGRKGK*RHLSKYSSNLIVKRLIG HELLLHLTKG*RRATPHWLCPLPPK*VTCPTTRW DHLCCSPEGLLQEALTPHTFPGLSFPYLSSPPE GMSTGHGACLVSLPVVQA*PVVSCVLLPAWDAQ GRRGDPQEGGWDTPDTSALIACLQMLYGHLCAKS Y*IKKTG*NPDAVYSFVIMYKVKQF*TVKIFFS VFSRILPQHTGFVFYLSFFLVTSFRPL*SLPQP FQKIINFL*SS

Sequence AKAP13.aAug05

TGAGTTGAAGTGGGGGAAATAGAGGAGTAAATCATTTCACGATGTGTGGTTAAGTGCTGCAGCTCAGGTAACCACCAGTACACAGAGGAAGGGCGGTTTC TGGAGACAGGGCGGAGAGGAGACCGTGGGTGGGCATTTCCCAGAGCAGCCTCTGCCAGCCACCCTACTTTGATCACTTTGCCGCCGAGCAGCAGCGGCGG TCAACCTCAGCCTCCCTTAGCAACCTGAGTGCCCCGTCCAGGAGCCTTACTATTGGTCTCATGCAGCGAGATGGGCAGTTCTGCCGTGCAATCCCAGCTC GCAGTTCTTGCTCCGCGTGTACTCACGGGAGGACTCGCAGGCGTTACCGCCTTCCCGCGTGCCCCGCCCACCCTCCCGAGCGTCTTTCGGCGCATGCGCG GACTGGAGCTGTGTGCAGGGCCAGCGCGGAGCCCGAGCAGCCGCGGTGAAGCGCCTGTGCTCTGCCGAGACTGCCGTGCCCATTGCTCGCCTCGGTCGCC GCCGCTTTAGCCGCCTCCGGGGGAGCGGCCGCCTATTGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGC CGCACGTGTCCTGGGTCATGAAACTTAATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGA TGATGTAGTGTTTTACTTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTGCTCCTGGT CATGATTGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACTTTCATTTCGTCCAGGATG AAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTCTTGACCAGTCAGGACCCCCATCTGGGGA TGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGTGGAATGTATTGGGGACAGATCAGAGTTTGCATGATGCT GGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGTTGACGTGGTTCCTGTTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTA TCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGGAGCGAGGCTATCACAAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGA CTCCTGGAGCAGTTTATCCTATGAAATACCGTATGGAGACTGTTCTGTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCA CATCATGAACACCCATTTCCTGGAGACGGTTGCACTGGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGG ACAGTCTTATGCCCTTAATGATGACAGCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCA GCGACTTTCTTCTTCTGAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCATAGTTGAG GAGGAGAATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTGTGGACTCTGGAACTGTAT CTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTGGAAACAGAAATGAAGAAACTGGAACAAA ATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAGACTTGGTCATGGAGCCAGGCACAGCCCAGTATTCCTCT GGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTGCAGGGGAAATGGAACATGGGCTCATGAACCCAGATGCCACTGTTTGGA AGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTGAGAACTCTAATATTGGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGT GGATAAAATCAGTGTTCCAAACTGTGCCCCTGCTGCCAGTTCCCTGGATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCC ACTGAAAAAACAGCAGAAACGGAAACTTCACGAAGTCGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAG ACAAGATTTCAGATGGATTAGAACCTTATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGA TGTAATGCCACACCAGAACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTT TGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACCACAG CAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGGGATACCCAGGAACG TGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAGATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACAT CCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAGTAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAAT CAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAAAAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCC AGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGGGCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGG AATACCAGTCTCACAGGACTTGGTGGAGAGCATGAGGGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGC AAAGTGTGGGTAAGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAA GGATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAA CAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCAGAAA CTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGTCTGGCCACAGAGTC AAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAGATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAG CCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTAGTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTA ATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACACAACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGC CGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGACCCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAG CTGGAGGGAGCAGACCACAGCTGTACCATGGGTGACGCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGC TCCCCACAGACATGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCC CTCTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAA CAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAGAGTG CTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCAGGATGTTTTGCTGG AAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCA AGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTA CAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCAAGCAGAGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTC AAAACAAGGTGTACTTAAAAGAGAATCTGGGAGTGATTCTGACCTCTTTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAA GAGCATTTGGCCTGTGATATCACCGGATCCAGTTCATCCACCGATGACACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCC AGATTTTAAAGCCAAACAGGTCAAGAGATCGGCAAAGCCTTGATGGATTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGC TGACCCAGGCGACGTGGAGGAGGAGGAGATGGACAGTATCACTGAAGTGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTC CGGAGGCACAGCTGGGGGCCTGGGAAAAATGCAGCCAGCGATGCAGAAATGAACCACCGGAGTATGAGCTGGTGCCCCTCTGGTGTGCAGTACTCTGCTG GCCTGAGTGCTGACTTTAATTACAGAAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGGTGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTC TGCAAATGCCGAAGAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTGTCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAA CATAGGATGTTTGATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTACATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCAT TAATGACAATCAGCCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAATACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAA CTATAATTTCCTGCCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAAGTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCT AGCAGCAAGAAGAGCAAAGAAAAGGAAAAAGAAAAAGATAAGATTAAGGAGAAGGAGAAAGATTCTAAAGACAAGGAGAAAGATAAGAAGACTGTCAACG GGCACACTTTCAGTTCCATTCCTGTTGTGGGTCCCATCAGCTGTAGCCAGTGTATGAAGCCCTTCACCAACAAAGATGCCTATACTTGTGCAAATTGCAG TGCTTTTGTCCACAAAGGCTGCCGAGAAAGTCTAGCCTCCTGTGCAAAGGTCAAAATGAAGCAGCCCAAAGGGAGCCTTCAGGCACATGACACATCATCA CTGCCCACGGTCATTATGAGAAACAAGCCCTCACAGCCCAAGGAGCGTCCTCGGTCCGCAGTCCTCCTGGTGGATGAAACCGCTACCACCCCAATATTTG CCAATAGACGATCCCAGCAGAGTGTCTCGCTCTCCAAAAGTGTCTCCATACAGAACATTACTGGAGTTGGCAATGATGAGAACATGTCAAACACCTGGAA ATTCCTGTCTCATTCAACAGACTCACTAAATAAAATCAGCAAGGTCAATGAGTCAACAGAATCACTTACTGATGAGGGAGTAGGTACAGACATGAATGAA GGACAACTACTGGGAGACTTTGAGATTGAGTCCAAACAGCTGGAAGCAGAGTCTTGGAGTCGGATAATAGACAGCAAGTTTCTAAAACAGCAAAAGAAAG ATGTGGTCAAACGGCAAGAAGTAATATATGAGTTGATGCAGACAGAGTTTCATCATGTCCGCACTCTCAAGATCATGAGTGGTGTGTACAGCCAGGGGAT GATGGCGGATCTGCTTTTTGAGCAGCAGATGGTAGAAAAGCTGTTCCCCTGTTTGGATGAGCTGATCAGTATCCATAGCCAATTCTTCCAGAGGATTCTG GAGCGGAAGAAGGAGTCTCTGGTGGATAAAAGTGAAAAGAACTTTCTCATCAAGAGGATAGGGGATGTGCTTGTAAATCAGTTTTCAGGTGAGAATGCAG AACGTTTAAAGAAGACATATGGCAAGTTTTGTGGGCAACATAACCAGTCTGTAAACTACTTCAAAGACCTTTATGCCAAGGATAAGCGTTTTCAAGCCTT TGTAAAGAAGAAGATGAGCAGTTCAGTTGTTAGAAGGCTTGGAATTCCAGAGTGCATATTGCTTGTAACTCAGCGGATTACCAAGTACCCAGTTTTATTC CAAAGAATATTGCAGTGTACCAAAGACAATGAAGTGGAGCAGGAAGATCTAGCACAGTCCTTGAGCCTGGTGAAGGATGTGATTGGAGCTGTAGACAGCA AAGTGGCAAGTTATGAAAAGAAAGTGCGTCTCAATGAGATTTATACAAAGACAGATAGCAAGTCAATCATGAGGATGAAGAGTGGTCAGATGTTTGCCAA GGAAGATTTGAAACGGAAGAAGCTTGTACGTGATGGGAGTGTGTTTCTGAAGAATGCAGCAGGAAGGTTGAAAGAGGTTCAAGCAGTTCTTCTCACTGAC ATTTTAGTTTTCCTTCAAGAAAAAGACCAGAAGTACATCTTTGCATCATTGGACCAGAAGTCAACAGTGATCTCTTTAAAGAAGCTGATTGTGAGAGAAG TGGCACATGAGGAGAAAGGTTTATTCCTGATCAGCATGGGGATGACAGATCCAGAGATGGTAGAAGTCCATGCCAGCTCCAAAGAGGAACGAAACAGCTG GATTCAGATCATTCAGGACACAATCAACACCCTGAACAGAGATGAAGATGAAGGAATTCCTAGTGAGAATGAGGAAGAAAAGAAAATGTTGGACACCAGA GCCCGAGAATTAAAAGAACAACTTCACCAGAAGGACCAAAAAATCCTACTCTTGTTGGAAGAGAAGGAGATGATTTTCCGGGACATGGCTGAGTGCAGCA CCCCTCTCCCAGAGGATTGCTCCCCAACACATAGCCCTAGAGTTCTCTTCCGCTCCAACACAGAAGAGGCTCTCAAAGGAGGACCTTTAATGAAAAGTGC AATAAATGAGGTGGAGATCCTTCAGGGTTTGGTGAGTGGAAATCTGGGAGGCACACTTGGGCCGACTGTCAGCAGCCCCATTGAGCAAGATGTGGTCGGT CCCGTTTCCCTGCCCCGGAGAGCAGAGACCTTTGGAGGATTTGACAGCCATCAGATGAATGCTTCAAAAGGAGGCGAGAAGGAAGAGGGAGATGATGGCC AAGATCTTAGGAGAACGGAATCAGATAGTGGCCTAAAAAAGGGTGGAAATGCTAACCTGGTATTTATGCTTAAAAGAAACAGTGAGCAGGTTGTCCAGAG CGTTGTTCATCTCTACGAGCTCCTCAGCGCTCTGCAGGGTGTGGTGCTGCAGCAGGACAGCTACATTGAGGACCAGAAACTGGTGCTGAGCGAGAGGGCG CTCACTCGCAGCTTGTCCCGCCCGAGCTCCCTCATTGAGCAGGAGAAGCAGCGCAGCCTGGAGAAGCAGCGCCAGGACCTGGCCAACCTGCAGAAGCAGC AGGCCCAGTACCTCGAGGAGAAGCGCAGGCGCGAGCGTGAGTGGGAAGCTCGTGAGAGGGAGCTGCGGGAGCGGGAGGCCCTCCTGGCCCAGCGCGAGGA GGAGGTGCAGCAGGGGCAGCAGGACCTGGAAAAGGAGCGGGAGGAGCTCCAGCAGAAGAAGGGCACATACCAGTATGACCTGGAGCGACTGCGTGCTGCC CAGAAACAGCTTGAGAGGGAACAGGAGCAGCTGCGCCGGGAGGCAGAGCGGCTCAGCCAGCGGCAGACAGAACGGGACCTGTGTCAGGTTTCCCATCCAC ATACCAAGCTGATGAGGATCCCATCGTTCTTCCCCAGTCCTGAGGAGCCCCCCTCGCCATCTGCACCTTCCATAGCCAAATCAGGGTCATTGGACTCAGA ACTTTCAGTGTCCCCAAAAAGGAACAGCATCTCTCGGACACACAAAGATAAGGGGCCTTTTCACATACTGAGTTCAACCAGCCAGACAAACAAAGGACCA GAAGGGCAGAGCCAGGCCCCTGCGTCCACCTCTGCCTCTACCCGCCTGTTTGGGTTAACAAAGCCAAAGGAAAAGAAGGAGAAAAAAAAGAAGAACAAAA CCAGCCGCTCTCAGCCCGGTGATGGTCCCGCGTCAGAAGTATCAGCAGAGGGTGAAGAGATCTTCTGCTGACCCTCTTCCTCTCTGCTGAGGCAGCTGCC TCCTGATCCTGGCCAGCCCACCTCTCCTGCTGTCCCCGCGTGCACAAGTCTCTTACACTGGACGCCCACTGCTCCTCAGCGTCCAGTCCTCCTGGGCGGC CCCAGGTCCTGGACAATAAGCAACAGATGATATTGAGTGTCGGGTGGGGAAGGAGGCCCAGACTCTGCTTCGGCCATGATTTGTGACTGCCCAGGACTCT CAGGTTGGGCTGGCCCTACTCAGGATTACACTGAAAGTAATGGCCTCGTAAGTACAGGTGATGGTTTTGGACACGTCAGGAATTCCTAAAGGCTGAAAGA GTGTATCCAAGTAAGGTCTGAACCTCCGAATGCCTTTTATTTGGGGGAACACAAAACCAAACAGCAGATGTTTTGGACTTGATCTGTGTACGTACATGGG GACCTGTCTGCATATACACACGGGGAATGCCAGAAGAAGGCCCAGTCTGCACCAGGCGTCTGGTCAACTTAGCACAAGGGCAGTGCCTGGACGGACCCGG AGCCCCCGCATATCAGCAGTTCACCCAGTACTCCTCAGAGACTGGTTTCCCTCTAAACCCATCCCGGGCACATACCACCCGTGTTTTGCATGTATTTCTC ATTTCATTTTAGGGATGACAAACATTTGTGAAACCAGTGAGAGAAGGCTTGATGTGTATAAAAGACGTGATGTGCACCACCTCGATCTCGGTGTTTCAGG CACTAAAGCAACAAAACAACCCATAGTATCTCATTCTGTCATCAGATCCAGAAGAAATATCCTGGTTTTCCAGCATGTTTACCCACATGTTTTGGCCATG GATAAAGTGAAGAGGCCTACTCACCATTATCCCTGCAGCGTGACACCTTTTGATTGTCACTGACCACTCAGAAGGGGCCACGGCCTCCTGGCTGTGTTCC TGAGCCCCCGTCGTGCCTCTCCCAGACAGCAGCTGTCTGGCCCTTGCTGGGTGAGGGCACACCACTGCCAGGGGTCAGCCTCGCACCCAGGCCAGGCAGA AGCTGTGCTCTGAAGCTAGGACAGCTGGCTGAGAAGTGGGTTCAGGCGAAGGGTGAAGCCATGTGTAGCAGTTCCTGCCAGTGCAGATCTGGAGAGGAGC TGGCCCGGAAGGCGTGGTTGTGAAAGCGCCCTTCTTATGTTAGGAGGCCTTGGCAAAATTGGATTTCTTCAAAAATACATGTAAAGGTCTGTTGTTGAAT TGTACTCTGCCCCTGGAAGCAGATACAGATGGCTGCCTGCTGCTCGGCTTTGCTTTTGCTTTTCCCACCGTGTTTTCATCTTTGTTCACTTGAGGCTTTC CCCAGCTGGTGTGTGCAGGACAGTTCATGGTAATGTTGCCCTCTGAGGCCCCGTACACCAGAAGGGAGGCCCTGGAAAATTTTGTGCTTCCAACGTGGCC TTCAATTCTTGCTTTTTTGCCCCTCGGAAGCATGGGGCTTTTGAGCACACTTAAAAAAAGAAAAATCTGTAACTTGGTGCTTATTGATGAATTGCAAGCT GGCCTTGCAGATGGAGATATTTATCTTTCAGTTTATTTGAAAGAGGTCTGGTTTAAAATTTGTAGCCTACATTTGTTTTATTTATTGTATTTGTGTGTTT GTGTTTGTTTTTTTTTAAGGGTGAGCCAGGTCTAGCCCAACAGTCTAAACTATCCAGTCAATACCGAGTGAAGTGGCAGCCAGCACTGTTCACTCTGTGT CTTTTGAAGTGCCTTGAAGGCCCAGATGAAATTTTAAAGGGAGGGGGTCCATGTCCTTCCCTCCCCCACCCCGCCTCATTCTTTAATCAAAGGATGTCTT CTCCCTTGTTTGAGAATGAAGAAACTCGCCACCTCTGACCTACCTTTGCCTTTTTCTGTCATGGAGAATACTCACCCTTCAGAAACAGACCAAAGGCCAA AACCTGCTGATTTTTCTATTGAAAATATGTCCCCTTGCAAAGACCCTAAACAAAAAGTTAAGTTTCTTTCTTTCACCTATTTGTACAACTCCAAGTTACA GCTGAATCTGTCGTGACTTTCCTGAGATCTACCCGGGGCTTGGCTGTCTGTTCTGGGCACTGGCTCCGAGTTCCCCTCCTGGGATTTGCAGGAGGGCAGT ACTGAACCTGCATTCTTCTCCTTGTAAATGTAGGCCGGGTGCCCCTGTTCTCCGGGTTTGGAACAATACGAGGTTGGTGCTGATGGGATTTACTTGCGTA CGTGCTCTTCACAAAAACACCGTGGATGCTGAAGTTAGAGCACGTCGCCACAGAGCTTGACATCAATGTTAGAGGGTCTCTTACTCCCCGCCCAGCTGTG ATGTTTCATCTGCTTTGGTTGTTTTGGTGGTCTTTTTTAAAAATAGAGATTTCACATCTGCCCAGACCCCACTCAAAACGATTTGGTCAGGTTCTGGTTG GACAAGTTTAAAATCAAAGTAGTGCCCGGAATTCCCTCAAACCACCCAACTTCATCCAGGAATACAGTCTGCAGTGCAGCAACAGAACCGCTTACCAAGA ACTGTGCTTACATACCTTTGTCATCTCTCTTCCCCCCTTGGAAGTTGTCCTCAGGGGGATTTGTTCCTGTCCTGGGGATTTACCTGGGATGGTGGCTGCC TGTGCTTTTGCTCATGGCCTTGACAGTGCTCTAGTTGCTGGATCTAATGGCCTGTCTTGGTTTCTATCACATGAGAAGGGGTTGTTTTTTTGGGGTGACT CGGACTGAATTCCCCATACTGTTTCCACGCCGGGACACCATGTTCTCCATCAAGCTAAAGAAATCACGTGCCTGAAACTGTGCTTAAGTTTTGGGGGAAA GATGGAGTTCCTATCCAGAGCCCCCAGATTTCCAGAATCGAGTGAGCTTCCTGGAAGGAGACTGCGTCTTCTCTCAATTCCAGTCATCTCAGTCGTTGTC GTTAGGTGACATGTGCACTTTAAATGCTCTCATCGGTTGGCTTCATTTTCAAGACAATCAAATGTATTGACTGTGTTTTCTTCTTAGAAAATGGAGAGGG TTAAAAACATGCAAACTGCCACTTTCAACCTTTGCCAGTATTCCCTCTACCCCCGTGAGAGCTATCTGGGGGGAAGAATCCTTACCAAGGTTTTTTTGGA AAGGTACGAATCTTAACTTTTTTCCCCTTCTGTGTCTCAGGGTAATACTATTCAGAGTCGCCCCTTTGCTCATTTTCTCCCGTATTTGTTACCTTCCTGA GGCCTCAGTATTAGTCGTGAGCACAAAGTTTTGAGACCTTTGGCGTTGTTTCTTGATGTGGGAGGGGAGGTGTTAGTGCATGCAAGGGTTGAACTAGATA GACCCTGCCTTAGTAGAGGGTGGGACTATAACCTTAGAGGCCAGAACTTGATCCAGAAGTTGCTGTCCACAGAAGTGCTTTCTATTTCATCATTTTTGTT TCTAGGGCTCTTTTTCTGTAGCCAGGTCTTCCCAAGGATTTTAGTATTTGCATTGGAGTTGAGGTTTACTCTAATGATGGTGGCCCAGCTGTGCCCAGAG GACAGCCAGGCAGGCCCTGGGAGGGAGTTTAGAAAGACAGTCCTGGTGAATGGGCTTCAAGTGGTCACAAAGAGGGTGGCTGTGAGGTGACCCCAGACAC TGCAGAACGATGTGCACCCTCTGCGTTTTGGATGTCCTTGGAATGTGGGAGCCTAGAAATAACCCTGTGGATGGAATTGGGGCAGCGGCTGCTGGAGATC TGTGTGCCTTGCCTTCCTTCAGCAGGACCGTCTAGGTGCGCAGCCACCTATGGATGCGTCCCAGCCAGCCCCGTCGCTCTCGTCCATCCTCAGAGACAAA GAAGAGGGCAGGGAGTTTGGGCTTGGTTTTGAACTTTCCTTTCAATGTAGCAAAGCATTCCTAGTTAACCAGAGCCTTGGAATCTACTGCCTGCTGGCCA GGCTTTAAAATGAAAAGTGTTTTAATGCTGCCATAAAAGGGAGGCGGGGGGGAGGAAGGGAAAATAAAGGCATCTTTCCAAGTACTCATCTAATTTAATT GTCAAAAGATTGATAGGCCATGAATTACTTCTCCATCTCACTAAGGGTTAAAGGCGTGCAACCCCCCACTGGCTGTGTCCCCTGCCACCGAAGTGAGTGA CCTGCCCTACAACCAGGTGGGACCACCTGTGCTGCAGTCCGGAGGGGCTTCTGCAGGAAGCACTCACCCCCCACACCTTCCCCGGCCTGAGCTTCCCCTA CCTTTCGTCACCACCTGAGGGCATGAGCACAGGCCATGGGGCGTGCCTGGTGAGTCTGCCTGTGGTTCAGGCTTAGCCTGTGGTCTCCTGTGTGCTGCTG CCCGCATGGGATGCGCAGGGGAGGCGTGGGGATCCGCAGGAGGGTGGTTGGGATACACCGGATACCTCTGCTCTCATTGCTTGTTTGCAAATGCTCTATG GACATTTGTGTGCTAAATCCTATTAAATAAAAAAGACGGGTTAAAACCCAGATGCTGTATATTCATTTGTAATTATGTATAAAGTGAAGCAGTTTTAAAC TGTAAAGATTTTTTTCAGTGTGTTTTCTCGAATTTTGCCACAACATACTGGCTTCGTATTTTATTTATCTTTCTTTCTAGTTACCAGCTTCAGACCCTTG TAAAGTCTCCCTCAGCCCTTTCAAAAAATAATAAATTTCCTGTGAAGTTCTGG

AKAP13-F1 (forward primer)
AKAP13-R1 (reverse primer)
Single exon skipping

Sequence Tools

Translations

Frame 0

*VEVGEIEE*IISRCVVKCCSSGNHQYTEEGRF LETGRRGDRGWAFPRAASASHPTLITLPPSSSGG QPQPPLAT*VPRPGALLLVSCSEMGSSAVQSQL AVLAPRVLTGGLAGVTAFPRAPPTLPSVFRRMR GLELCAGPARSPSSRGEAPVLCRDCRAHCSPRSP PL*PPPGERPPIVFLRGEGEELSQLGPRGSPGS RTCPGS*NLIHSKLPYMVIVLLQCCLLKRTKLK MM*CFTWYFWVPPSVTVQVLGRSVLIHWRPLLLV MIVVKQ*RCSSVLPKRAFPCLWWLKKTFISSRM KRMMQLNS*QPVLEISRL*TLPVFLTSQDPHLG M*IPLIRSWCWHSGT*SCPRSGMYWGQIRVCMML ARERH*CILLCGWDC*G*RGSCCRSQVAAELSV STTRKGRRL*AWPWSEAITSCTSF*PRRMLENQ TPGAVYPMKYRMETVL*GIIESWTSIH*PLSLIH IMNTHFLETVALDQFLNL*TSNSN**KQTSSRW TVLCP***QHRILPVPQRQMASFFPVHRSPRTL SDFLLLKRLRALSAAQGALLHRLKVPVICQA*LR RRIQTVPVGRKIKAWKEKGKRWSQHLLWTLELY LIKTAAFRACLIVE*RARKAFRPVETEMKKLEQ NLLECPQTRSP*AVEMLCFRETWSWSQAQPSIPL EVNWEAFQQQMSVPQTLQGKWNMGS*TQMPLFG RMCFREGKVQRKDLRTLILAQLEPLTCTSQVSL WIKSVFQTVPLLPVPWMVTNLLSLHLHLVMKKPP LKKQQKRKLHEVVRRVLMLQ*IRILW*FQLLQK TRFQMD*NLILS*QQA*VRQCHPQI*PFLGWKK M*CHTRTQKQIHLMLKAKRANPHPFVLQLETINF VQTLHVNRTQ*LLVAIWLQNCVIT*LASPKAPQ QGNPAHKIHPMPPTVKTHRLIQSPLTL*GIPRN VRIFVLSKWWITKANEKM*N*INL*QICLRWFHI HIQLSLKWRKNWCQTRQ*YQTVLSLWQTVQAVN Q*PRMTHFLLSPPRKKREQQLLNYIQLQIIEMA QMEIRMSLIRGH*KTGQ*ACPHPPLLQSFSTGWG IPVSQDLVESMRVPPLQQSQKL*ISRGTLTLPC KVWVRPLWL*IQF*LKKENFWWFQKALQLRNKI RIKR*PVPLLRKMLSLQELCRKSREHHLLDKILN NFMKNQSQLTVPRTKHFS*VIHRVHPLPFLRQK LNITRKWPHKSHC*LKVGLPRAWCHQEQVWPQS QGRKPWGQSTTAPLCCHVCCQMGLMGPMLLTAVS LLLWMLE*RTLNPREKLVPVR*VEM*RWMLQGL MLYKVWLSPEERIYHTTPKTS*FQTSC*AKRRM PF*VCQWLYRTKL*LTHRELEPQR*YLLIGRKGS WREQTTAVPWVTLRKPK*TMKHILSYCSLLPRS SPQTWSSQPMMMGPQLV*GKSCEPRLQAGKGAL PLYLAWSLPRTHLCLRGQT**RRLPAV*WMLSSN KSRPLEHCLLRGRPVTCHCPALSWVLSLKD*RV LLQKK*VLSHLGRAYQWAVLLRKPRGALQDVLL EGRSQRRSFYLSRGLSQQQKCQT*KLKMKWILEQ VQFLKKWL*GA*LLH*R*SKAQ*PRR*TEKTGV Q*SHALMQHLFWLPSRAQNVRTSWMLDWAESVP QNKVYLKENLGVILTSFTHPVMTWTASSSQSQRK SIWPVISPDPVHPPMTRLHWTDILLMAVMCLSP RF*SQTGQEIGKALMDSTAMGWELRVEKVRVSL LTQATWRRRRWTVSLKCLQTALS*GAPCALFLPS GGTAGGLGKMQPAMQK*TTGV*AGAPLVCSTLL A*VLTLITEVSV*KA*QEELVSETSHPHL*K*A LQMPKSSDTHSVVRNGLTLWCHFQKRIWSQTREN IGCLISRYVTDLSSRDLITVHQPFPLH*QNPSH **QSAILDWTIHGPSTVPSTIPVLI*LRV*QKR TIISCHIAPPRKILNGRVEQKSVVHSATSRIKCL AARRAKKRKKKKIRLRRRRKILKTRRKIRRLST GTLSVPFLLWVPSAVASV*SPSPTKMPILVQIA VLLSTKAAEKV*PPVQRSK*SSPKGAFRHMTHHH CPRSL*ETSPHSPRSVLGPQSSWWMKPLPPQYL PIDDPSRVSRSPKVSPYRTLLELAMMRTCQTPG NSCLIQQTH*IKSARSMSQQNHLLMRE*VQT*MK DNYWETLRLSPNSWKQSLGVG**TASF*NSKRK MWSNGKK*YMS*CRQSFIMSALSRS*VVCTARG *WRICFLSSRW*KSCSPVWMS*SVSIANSSRGFW SGRRSLWWIKVKRTFSSRG*GMCL*ISFQVRMQ NV*RRHMASFVGNITSL*TTSKTFMPRISVFKP L*RRR*AVQLLEGLEFQSAYCL*LSGLPSTQFYS KEYCSVPKTMKWSRKI*HSP*AW*RM*LEL*TA KWQVMKRKCVSMRFIQRQIASQS*G*RVVRCLP RKI*NGRSLYVMGVCF*RMQQEG*KRFKQFFSLT F*FSFKKKTRSTSLHHWTRSQQ*SL*RS*L*EK WHMRRKVYS*SAWG*QIQRW*KSMPAPKRNETA GFRSFRTQSTP*TEMKMKEFLVRMRKKRKCWTPE PEN*KNNFTRRTKKSYSCWKRRR*FSGTWLSAA PLSQRIAPQHIALEFSSAPTQKRLSKEDL**KV Q*MRWRSFRVW*VEIWEAHLGRLSAAPLSKMWSV PFPCPGEQRPLEDLTAIR*MLQKEARRKREMMA KILGERNQIVA*KRVEMLTWYLCLKETVSRLSR ALFISTSSSALCRVWCCSRTATLRTRNWC*ARGR SLAACPARAPSLSRRSSAAWRSSARTWPTCRSS RPSTSRRSAGASVSGKLVRGSCGSGRPSWPSAR RRCSRGSRTWKRSGRSSSRRRAHTSMTWSDCVLP RNSLRGNRSSCAGRQSGSASGRQNGTCVRFPIH IPS**GSHRSSPVLRSPPRHLHLP*PNQGHWTQ NFQCPQKGTASLGHTKIRGLFTY*VQPARQTKDQ KGRARPLRPPLPLPACLG*QSQRKRRRKKRRTK PAALSPVMVPRQKYQQRVKRSSADPLPLC*GSC LLILASPPLLLSPRAQVSYTGRPLLLSVQSSWAA PGPGQ*ATDDIECRVGKEAQTLLRP*FVTAQDS QVGLALLRITLKVMAS*VQVMVLDTSGIPKG*K SVSK*GLNLRMPFIWGNTKPNSRCFGLDLCTYMG TCLHIHTGNARRRPSLHQASGQLSTRAVPGRTR SPRISAVHPVLLRDWFPSKPIPGTYHPCFACIS HFILGMTNICETSERRLDVYKRRDVHHLDLGVSG TKATKQPIVSHSVIRSRRNILVFQHVYPHVLAM DKVKRPTHHYPCSVTPFDCH*PLRRGHGLLAVF LSPRRASPRQQLSGPCWVRAHHCQGSASHPGQAE AVL*S*DSWLRSGFRRRVKPCVAVPASADLERS WPGRRGCESALLMLGGLGKIGFLQKYM*RSVVE LYSAPGSRYRWLPAARLCFCFSHRVFIFVHLRLS PAGVCRTVHGNVAL*GPVHQKGGPGKFCASNVA FNSCFFAPRKHGAFEHT*KKKNL*LGAY**IAS WPCRWRYLSFSLFERGLV*NL*PTFVLFIVFVCL CLFFFKGEPGLAQQSKLSSQYRVKWQPALFTLC LLKCLEGPDEILKGGGPCPSLPHPASFFNQRMS SPLFENEETRHL*PTFAFFCHGEYSPFRNRPKAK TC*FFY*KYVPLQRP*TKS*VSFFHLFVQLQVT AESVVTFLRSTRGLAVCSGHWLRVPLLGFAGGQ Y*TCILLLVNVGRVPLFSGFGTIRGWC*WDLLAY VLFTKTPWMLKLEHVATELDINVRGSLTPRPAV MFHLLWLFWWSFLKIEISHLPRPHSKRFGQVLV GQV*NQSSARNSLKPPNFIQEYSLQCSNRTAYQE LCLHTFVISLPPLEVVLRGICSCPGDLPGMVAA CAFAHGLDSALVAGSNGLSWFLSHEKGLFFWGD SD*IPHTVSTPGHHVLHQAKEITCLKLCLSFGGK MEFLSRAPRFPESSELPGRRLRLLSIPVISVVV VR*HVHFKCSHRLASFSRQSNVLTVFSS*KMER VKNMQTATFNLCQYSLYPRESYLGGRILTKVFLE RYES*LFSPSVSQGNTIQSRPFAHFLPYLLPS* GLSISREHKVLRPLALFLDVGGEVLVHARVELD RPCLSRGWDYNLRGQNLIQKLLSTEVLSISSFLF LGLFFCSQVFPRILVFALELRFTLMMVAQLCPE DSQAGPGREFRKTVLVNGLQVVTKRVAVR*PQT LQNDVHPLRFGCPWNVGA*K*PCGWNWGSGCWRS VCLAFLQQDRLGAQPPMDASQPAPSLSSILRDK EEGREFGLGFELSFQCSKAFLVNQSLGIYCLLA RL*NEKCFNAAIKGRRGGGRENKGIFPSTHLI*L SKD**AMNYFSISLRVKGVQPPTGCVPCHRSE* PALQPGGTTCAAVRRGFCRKHSPPTPSPA*ASP TFRHHLRA*AQAMGRAW*VCLWFRLSLWSPVCCC PHGMRRGGVGIRRRVVGIHRIPLLSLLVCKCSM DICVLNPIK*KRRVKTQMLYIHL*LCIK*SSFK L*RFFSVCFLEFCHNILASYFIYLSF*LPASDPC KVSLSPFKK**ISCEVL

Frame 1

ELKWGK*RSKSFHDVWLSAAAQVTTSTQRKGGF WRQGGEETVGGHFPEQPLPATLL*SLCRRAAAA VNLSLP*QPECPVQEPYYWSHAARWAVLPCNPSS QFLLRVYSREDSQALPPSRVPRPPSRASFGACA DWSCVQGQRGARAAAVKRLCSAETAVPIARLGR RRFSRLRGSGRLLSFSAAKVKSCPSSARGGAPGA ARVLGHET*STASSLIW*LCCYSAAC*RGQS*R *CSVLLGIFGFHPPSLYKYSEGQF*YIGDHCSW S*LL*NSEGAALCFQRGPSRVCGG*RRLSFRPG* SV*CSSIPSNQCWKSAGFELYPFS*PVRTPIWG CEFP**EVGAGIQAPEAAHGVECIGDRSEFA*C WPARDIDAFCCAAGTAEVDVVPVAEARWPRSSQY PQPGRGDACELGLGARLSQAAPASNRGECWRTR LLEQFIL*NTVWRLFCEASSRVGHLYINL*V*F TS*TPISWRRLHWTNF*TYEHPTATNENKPQADG QSYALNDDSTGSFQCPRDRWPVSSLCTGAHGPS ATFFF*RD*EHSVLPREPCCTD*KSL*FVKHS* GGEYRPFL*EEK*RRGKKRGRGGASTYCGLWNCI *SRQLPSELA*LWSKGHGRPFVLWKQK*RNWNK IFWNAHRPGVPEQWRCCASERLGHGARHSPVFL WR*TGRHFNNKCQYPRHCRGNGTWAHEPRCHCLE ECASGRGKYKGKI*EL*YWHSWSL*RARHK*AC G*NQCSKLCPCCQFPGW*QTC*VFTCI***RNL H*KNSRNGNFTKS*GEC*CSSRSEFCGDSSCCKR QDFRWIRTLYSLSSRHR*GNVTLRFSPSWAGRR CNATPELRNKFISCSKPKGQILTHLFYNWRR*T LCRLCMSTEHSDF*WRFGCKTV**HS*RVRKHHS KATQLTRSTRCLPL*RPTGSYSHL*PCKGYPGT CGFLSFQSGG*QRPTKRCETR*TFNKYA*GGFT STSSCP*NGERTGARPGSNIRQYFLSGKQSRQ*I SNQG*RTFFCPLPERKGNSNS*TTYSYRL*RWP RWKFE*A*YAATRRQGSRPVHILHCCRASARDG EYQSHRTWWRA*GSRPSSNPRSSEYQGEH*LFPA KCG*GHFGFRFSFD*RRKTSGGFRKLCSSGTR* G*SGDLFLY*GKCSLFRNFAGRAENTTSWTRYS TIS*KINLS*LCQGQSTSAK*FTGCILCLS*GRN *T*QGSGPTSLTADSRWGCPEPGATRSKSGHRV KAGSLGGRAQQLRSVAMSVARWV*WVRCS*LQS AFSSGCWSEEHSIPGKN*CL*GEWRCDGGCYRG* CSTRYG*AQKREYITQHPRHPDSKRLVEPREEC RSRFASGSTGQSCD*PTGSWNPRDDTS*LGERE AGGSRPQLYHG*R*GSPNRR*STSCPTAACCQGA PHRHGALSP**WGPSWCEGSHASPAFRQGKEHS LSTLHGLCPGRTSA*GGRLDRGGCQPYSGCCHR TSQGRWSTAY*GGGLSHVTVQP*VGSSH*RTREC FYRKSEYFPTWGEPTNGQYS*GSHGEPCRMFCW KGGAREDHFTCPGA*ASSRNARRES*R*SGF*S KFNF*RSGCREHSCYTEDEARPNDPGDKPRKLVY NRAMP*CSISSGFQAEPRM*ELPGCWTGQRVYL KTRCT*KRIWE*F*PLSLTQ**HGQHHLPKARG RAFGL*YHRIQFIHR*HGFTGPTFFSWQ*CVSLP DFKAKQVKRSAKP*WILQPWDGS*GSRK*E*AC *PRRRGGGGDGQYH*SACKLLCPKELHALSFSL PEAQLGAWEKCSQRCRNEPPEYELVPLWCAVLCW PEC*L*LQKFQSRRLDRRSWCRKQAILISRSKL CKCRRAQTPIQW*GTG*LFGVTFRRGSGVRPER T*DV*SADMSQI*AAGI*LLYISHFLSIDKIHLI NDNQPSWIGQFTALPQYLPQYQC*SD*EYNRRE L*FPAT*PLQERF*MEEWNKSQSYIQLHQE*NV *QQEEQRKGKRKR*D*GEGERF*RQGER*EDCQR AHFQFHSCCGSHQL*PVYEALHQQRCLYLCKLQ CFCPQRLPRKSSLLCKGQNEAAQREPSGT*HII TAHGHYEKQALTAQGASSVRSPPGG*NRYHPNIC Q*TIPAECLALQKCLHTEHYWSWQ**EHVKHLE IPVSFNRLTK*NQQGQ*VNRITY**GSRYRHE* RTTTGRL*D*VQTAGSRVLESDNRQQVSKTAKER CGQTARSNI*VDADRVSSCPHSQDHEWCVQPGD DGGSAF*AADGRKAVPLFG*ADQYP*PILPEDS GAEEGVSGG*K*KELSHQEDRGCACKSVFR*ECR TFKEDIWQVLWAT*PVCKLLQRPLCQG*AFSSL CKEEDEQFSC*KAWNSRVHIACNSADYQVPSFI PKNIAVYQRQ*SGAGRSSTVLEPGEGCDWSCRQQ SGKL*KESASQ*DLYKDR*QVNHEDEEWSDVCQ GRFETEEACT*WECVSEECSRKVERGSSSSSH* HFSFPSRKRPEVHLCIIGPEVNSDLFKEADCERS GT*GERFIPDQHGDDRSRDGRSPCQLQRGTKQL DSDHSGHNQHPEQR*R*RNS**E*GRKENVGHQ SPRIKRTTSPEGPKNPTLVGREGDDFPGHG*VQH PSPRGLLPNT*P*SSLPLQHRRGSQRRTFNEKC NK*GGDPSGFGEWKSGRHTWADCQQPH*ARCGR SRFPAPESRDLWRI*QPSDECFKRRREGRGR*WP RS*ENGIR*WPKKGWKC*PGIYA*KKQ*AGCPE RCSSLRAPQRSAGCGAAAGQLH*GPETGAEREG AHSQLVPPELPH*AGEAAQPGEAAPGPGQPAEAA GPVPRGEAQARA*VGSS*EGAAGAGGPPGPARG GGAAGAAGPGKGAGGAPAEEGHIPV*PGATACC PETA*EGTGAAAPGGRAAQPAADRTGPVSGFPST YQADEDPIVLPQS*GAPLAICTFHSQIRVIGLR TFSVPKKEQHLSDTQR*GAFSHTEFNQPDKQRT RRAEPGPCVHLCLYPPVWVNKAKGKEGEKKEEQN QPLSAR*WSRVRSISRG*RDLLLTLFLSAEAAA S*SWPAHLSCCPRVHKSLTLDAHCSSASSPPGR PQVLDNKQQMILSVGWGRRPRLCFGHDL*LPRTL RLGWPYSGLH*K*WPRKYR*WFWTRQEFLKAER VYPSKV*TSECLLFGGTQNQTADVLDLICVRTW GPVCIYTRGMPEEGPVCTRRLVNLAQGQCLDGPG APAYQQFTQYSSETGFPLNPSRAHTTRVLHVFL ISF*G*QTFVKPVREGLMCIKDVMCTTSISVFQ ALKQQNNP*YLILSSDPEEISWFSSMFTHMFWPW IK*RGLLTIIPAA*HLLIVTDHSEGATASWLCS *APVVPLPDSSCLALAG*GHTTARGQPRTQARQ KLCSEARTAG*EVGSGEG*SHV*QFLPVQIWRGA GPEGVVVKAPFLC*EALAKLDFFKNTCKGLLLN CTLPLEADTDGCLLLGFAFAFPTVFSSLFT*GF PQLVCAGQFMVMLPSEAPYTRREALENFVLPTWP SILAFLPLGSMGLLSTLKKRKICNLVLIDELQA GLADGDIYLSVYLKEVWFKICSLHLFYLLYLCV CVCFFLRVSQV*PNSLNYPVNTE*SGSQHCSLCV F*SALKAQMKF*REGVHVLPSPTPPHSLIKGCL LPCLRMKKLATSDLPLPFSVMENTHPSETDQRP KPADFSIENMSPCKDPKQKVKFLSFTYLYNSKLQ LNLS*LS*DLPGAWLSVLGTGSEFPSWDLQEGS TEPAFFSL*M*AGCPCSPGLEQYEVGADGIYLR TCSSQKHRGC*S*STSPQSLTSMLEGLLLPAQL* CFICFGCFGGLF*K*RFHICPDPTQNDLVRFWL DKFKIKVVPGIPSNHPTSSRNTVCSAATEPLTK NCAYIPLSSLFPPWKLSSGGFVPVLGIYLGWWLP VLLLMALTVL*LLDLMACLGFYHMRRGCFFGVT RTEFPILFPRRDTMFSIKLKKSRA*NCA*VLGE RWSSYPEPPDFQNRVSFLEGDCVFSQFQSSQSLS LGDMCTLNALIGWLHFQDNQMY*LCFLLRKWRG LKTCKLPLSTFASIPSTPVRAIWGEESLPRFFW KGTNLNFFPLLCLRVILFRVAPLLIFSRICYLPE ASVLVVSTKF*DLWRCFLMWEGRC*CMQGLN*I DPALVEGGTITLEART*SRSCCPQKCFLFHHFC F*GSFSVARSSQGF*YLHWS*GLL**WWPSCAQR TARQALGGSLERQSW*MGFKWSQRGWL*GDPRH CRTMCTLCVLDVLGMWEPRNNPVDGIGAAAAGD LCALPSFSRTV*VRSHLWMRPSQPRRSRPSSETK KRAGSLGLVLNFPFNVAKHS*LTRALESTACWP GFKMKSVLMLP*KGGGGEEGKIKASFQVLI*FN CQKIDRP*ITSPSH*GLKACNPPLAVSPATEVSD LPYNQVGPPVLQSGGASAGSTHPPHLPRPELPL PFVTT*GHEHRPWGVPGESACGSGLACGLLCAA ARMGCAGEAWGSAGGWLGYTGYLCSHCLFANALW TFVC*ILLNKKDGLKPRCCIFICNYV*SEAVLN CKDFFQCVFSNFATTYWLRILFIFLSSYQLQTL VKSPSALSKNNKFPVKFW

Frame 2

S*SGGNRGVNHFTMCG*VLQLR*PPVHRGRAVS GDRAERRPWVGISQSSLCQPPYFDHFAAEQQRR STSASLSNLSAPSRSLTIGLMQRDGQFCRAIPA RSSCSACTHGRTRRRYRLPACPAHPPERLSAHAR TGAVCRASAEPEQPR*SACALPRLPCPLLASVA AALAASGGAAAYCLSPRRR*RVVPARPAGEPRE PHVSWVMKLNPQQAPLYGDCVVTVLLAEEDKAED DVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPG HDCCETVKVQLCASKEGLPVFVVAEEDFHFVQD EAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGD VNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDA GPRETLMHFAVRLGLLRLTWFLLQKPGGRGALS IHNQEGATPVSLALERGYHKLHQLLTEENAGEPD SWSSLSYEIPYGDCSVRHHRELDIYTLTSESDS HHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQM DSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQ RLSSSEETESTQCCPGSPVAQTESPCDLSSIVE EENTDRSCRKKNKGVERKGEEVEPAPIVDSGTV SDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTK SSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSS GGELGGISTTNVSTPDTAGEMEHGLMNPDATVW KNVLQGGESTKERFENSNIGTAGASDVHVTSKPV DKISVPNCAPAASSLDGNKPAESSLAFSNEETS TEKTAETETSRSREESADAPVDQNSVVIPAAAK DKISDGLEPYTLLAAGIGEAMSPSDLALLGLEED VMPHQNSETNSSHAQSQKGKSSPICSTTGDDKL CADSACQQNTVTSSGDLVAKLCDNIVSESESTT ARQPSSQDPPDASHCEDPQAHTVTSDPVRDTQER ADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSH PHPVVPKMEKELVPDQAVISDSTFSLANSPGSE SVTKDDALSFVPSQKEKGTATPELHTATDYRDGP DGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMG NTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSL QSVGKATLALDSVLTEEGKLLVVSESSAAQEQDK DKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQ QFHEKSISADCAKDKALQLSNSPGASSAFLKAE TEHNKEVAPQVSLLTQGGAAQSLVPPGASLATES RQEALGAEHNSSALLPCLLPDGSDGSDALNCSQ PSPLDVGVKNTQSQGKTSACEVSGDVTVDVTGV NALQGMAEPRRENISHNTQDILIPNVLLSQEKNA VLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGK LEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKE LPTDMELSAHDDGAPAGVREVMRAPPSGRERSTP SLPCMVSAQDAPLPKGADLIEEAASRIVDAVIE QVKAAGALLTEGEACHMSLSSPELGPLTKGLES AFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAG REEPEKIILPVQGPEPAAEMPDVKAEDEVDFRA SSISEEVAVGSIAATLKMKQGPMTQAINRENWC TIEPCPDAASLLASKQSPECENFLDVGLGRECTS KQGVLKRESGSDSDLFHSPSDDMDSIIFPKPEE EHLACDITGSSSSTDDTASLDRHSSHGSDVSLS QILKPNRSRDRQSLDGFYSHGMGAEGRESESEPA DPGDVEEEEMDSITEVPANCSVLRSSMRSLSPF RRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSA GLSADFNYRSFSLEGLTGGAGVGNKPSSSLEVSS ANAEELRHPFSGEERVDSLVSLSEEDLESDQRE HRMFDQQICHRSKQQGFNYCTSAISSPLTKSIS LMTISHPGLDNSRPFHSTFHNTSANLTESITEEN YNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMS SSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVN GHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCS AFVHKGCRESLASCAKVKMKQPKGSLQAHDTSS LPTVIMRNKPSQPKERPRSAVLLVDETATTPIF ANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWK FLSHSTDSLNKISKVNESTESLTDEGVGTDMNE GQLLGDFEIESKQLEAESWSRIIDSKFLKQQKK DVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGM MADLLFEQQMVEKLFPCLDELISIHSQFFQRIL ERKKESLVDKSEKNFLIKRIGDVLVNQFSGENA ERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAF VKKKMSSSVVRRLGIPECILLVTQRITKYPVLF QRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDS KVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAK EDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTD ILVFLQEKDQKYIFASLDQKSTVISLKKLIVRE VAHEEKGLFLISMGMTDPEMVEVHASSKEERNSW IQIIQDTINTLNRDEDEGIPSENEEEKKMLDTR ARELKEQLHQKDQKILLLLEEKEMIFRDMAECS TPLPEDCSPTHSPRVLFRSNTEEALKGGPLMKSA INEVEILQGLVSGNLGGTLGPTVSSPIEQDVVG PVSLPRRAETFGGFDSHQMNASKGGEKEEGDDG QDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQS VVHLYELLSALQGVVLQQDSYIEDQKLVLSERA LTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQ QAQYLEEKRRREREWEARERELREREALLAQREE EVQQGQQDLEKEREELQQKKGTYQYDLERLRAA QKQLEREQEQLRREAERLSQRQTERDLCQVSHP HTKLMRIPSFFPSPEEPPSPSAPSIAKSGSLDSE LSVSPKRNSISRTHKDKGPFHILSSTSQTNKGP EGQSQAPASTSASTRLFGLTKPKEKKEKKKKNK TSRSQPGDGPASEVSAEGEEIFC*PSSSLLRQLP PDPGQPTSPAVPACTSLLHWTPTAPQRPVLLGG PRSWTISNR*Y*VSGGEGGPDSASAMICDCPGL SGWAGPTQDYTESNGLVSTGDGFGHVRNS*RLKE CIQVRSEPPNAFYLGEHKTKQQMFWT*SVYVHG DLSAYTHGECQKKAQSAPGVWST*HKGSAWTDP EPPHISSSPSTPQRLVSL*THPGHIPPVFCMYFS FHFRDDKHL*NQ*EKA*CV*KT*CAPPRSRCFR H*SNKTTHSISFCHQIQKKYPGFPACLPTCFGH G*SEEAYSPLSLQRDTF*LSLTTQKGPRPPGCVP EPPSCLSQTAAVWPLLGEGTPLPGVSLAPRPGR SCALKLGQLAEKWVQAKGEAMCSSSCQCRSGEE LARKAWL*KRPSYVRRPWQNWISSKIHVKVCC*I VLCPWKQIQMAACCSALLLLFPPCFHLCSLEAF PSWCVQDSSW*CCPLRPRTPEGRPWKILCFQRG LQFLLFCPSEAWGF*AHLKKEKSVTWCLLMNCKL ALQMEIFIFQFI*KRSGLKFVAYICFIYCICVF VFVFF*G*ARSSPTV*TIQSIPSEVAASTVHSV SFEVP*RPR*NFKGRGSMSFPPPPRLIL*SKDVF SLV*E*RNSPPLTYLCLFLSWRILTLQKQTKGQ NLLIFLLKICPLAKTLNKKLSFFLSPICTTPSY S*ICRDFPEIYPGLGCLFWALAPSSPPGICRRAV LNLHSSPCKCRPGAPVLRVWNNTRLVLMGFTCV RALHKNTVDAEVRARRHRA*HQC*RVSYSPPSC DVSSALVVLVVFFKNRDFTSAQTPLKTIWSGSGW TSLKSK*CPEFPQTTQLHPGIQSAVQQQNRLPR TVLTYLCHLSSPLGSCPQGDLFLSWGFTWDGGC LCFCSWP*QCSSCWI*WPVLVSIT*EGVVFLG*L GLNSPYCFHAGTPCSPSS*RNHVPETVLKFWGK DGVPIQSPQISRIE*ASWKETASSLNSSHLSRC R*VTCAL*MLSSVGFIFKTIKCIDCVFFLENGEG *KHANCHFQPLPVFPLPP*ELSGGKNPYQGFFG KVRILTFFPFCVSG*YYSESPLCSFSPVFVTFL RPQY*S*AQSFETFGVVS*CGRGGVSACKG*TR* TLP**RVGL*P*RPELDPEVAVHRSAFYFIIFV SRALFL*PGLPKDFSICIGVEVYSNDGGPAVPR GQPGRPWEGV*KDSPGEWASSGHKEGGCEVTPDT AERCAPSAFWMSLECGSLEITLWMELGQRLLEI CVPCLPSAGPSRCAATYGCVPASPVALVHPQRQ RRGQGVWAWF*TFLSM*QSIPS*PEPWNLLPAGQ ALK*KVF*CCHKREAGGRKGK*RHLSKYSSNLI VKRLIGHELLLHLTKG*RRATPHWLCPLPPK*V TCPTTRWDHLCCSPEGLLQEALTPHTFPGLSFPY LSSPPEGMSTGHGACLVSLPVVQA*PVVSCVLL PAWDAQGRRGDPQEGGWDTPDTSALIACLQMLY GHLCAKSY*IKKTG*NPDAVYSFVIMYKVKQF*T VKIFFSVFSRILPQHTGFVFYLSFFLVTSFRPL *SLPQPFQKIINFL*SS