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Sequence AKAP13.cAug05
GCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTTTGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACCACAGCAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAA
GACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGGGATACCCAGGAACGTGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAA
AAGATGTGAAACTAGATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACATCCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCA
GGCAGTAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAATCAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAA
AAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCCAGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGGG
CAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGGAATACCAGTCTCACAGGACTTGGTGGAGAGCATGAGGGTCCCGCCCC
TCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGCAAAGTGTGGGTAAGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAA
GAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAAGGATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTT
CAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAACAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGC
ACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCAGAAACTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAA
GGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGTCTGGCCACAGAGTCAAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGC
CATGTCTGTTGCCAGATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAGCCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAA
AACTAGTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTAATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACAC
AACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGCCGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGACC
CACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAGCTGGAGGGAGCAGACCACAGCTGTACCATGGGTGACGCTGAGGAAGC
CCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGCTCCCCACAGACATGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCT
GGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCCCTCTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGG
GGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAACAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCA
CATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAGAGTGCTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCA
ATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCAGGATGTTTTGCTGGAAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGC
CAGCAGCAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACT
GAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTACAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCAAGCAG
AGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTCAAAACAAGGTGTACTTAAAAGAGAATCTGGGAGTGATTCTGACCTCT
TTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAAGAGCATTTGGCCTGTGATATCACCGGATCCAGTTCATCCACCGATGA
CACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCCAGATTTTAAAGCCAAACAGGTCAAGAGATCGGCAAAGCCTTGATGGA
TTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGCTGACCCAGGCGACGTGGAGGAGGAGGAGATGGACAGTATCACTGAAG
TGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTCCGGAGGCACAGCTGGGGGCCTGGGAAAAATGCAGCCAGCGATGCAGA
AATGAACCACCGGAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGGTGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTCTGCAAATGCCGAA
GAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTGTCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAACATAGGATGTTTG
ATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTACATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCATTAATGACAATCAG
CCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAATACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAACTATAATTTCCTG
CCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAAGTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCTAGCAGCAAGAAGA
GCAAAGAAAAGGAAAAAGAAAAAGATAAGATTAAGGAGAAGGAGAAAGATTCTAAAGACAAGGAGAAAGATAAGAAGACTGTCAACGGGCACACTTTCAG
TTCCATTCCTGTTGTGGGTCCCATCAGCTGTAGCCAGTGTATGAAGCCCTTCACCAACAAAGATGCCTATACTTGTGCAAATTGCAGTGCTTTTGTCCAC
AAAGGCTGCCGAGAAAGTCTAGCCTCCTGTGCAAAGGTCAAAATGAAGCAGCCCAAAGGGAGCCTTCAGGCACATGACACATCATCACTGCCCACGGTCA
TTATGAGAAACAAGCCCTCACAGCCCAAGGAGCGTCCTCGGTCCGCAGTCCTCCTGGTGGATGAAACCGCTACCACCCCAATATTTGCCAATAGACGATC
CCAGCAGAGTGTCTCGCTCTCCAAAAGTGTCTCCATACAGAACATTACTGGAGTTGGCAATGATGAGAACATGTCAAACACCTGGAAATTCCTGTCTCAT
TCAACAGACTCACTAAATAAAATCAGCAAGGTCAATGAGTCAACAGAATCACTTACTGATGAGGGTACAGACATGAATGAAGGACAACTACTGGGAGACT
TTGAGATTGAGTCCAAACAGCTGGAAGCAGAGTCTTGGAGTCGGATAATAGACAGCAAGTTTCTAAAACAGCAAAAGAAAGATGTGGTCAAACGGCAAGA
AGTAATATATGAGTTGATGCAGACAGAGTTTCATCATGTCCGCACTCTCAAGATCATGAGTGGTGTGTACAGCCAGGGGATGATGGCGGATCTGCTTTTT
GAGCAGCAGATGGTAGAAAAGCTGTTCCCCTGTTTGGATGAGCTGATCAGTATCCATAGCCAATTCTTCCAGAGGATTCTGGAGCGGAAGAAGGAGTCTC
TGGTGGATAAAAGTGAAAAGAACTTTCTCATCAAGAGGATAGGGGATGTGCTTGTAAATCAGTTTTCAGGTGAGAATGCAGAACGTTTAAAGAAGACATA
TGGCAAGTTTTGTGGGCAACATAACCAGTCTGTAAACTACTTCAAAGACCTTTATGCCAAGGATAAGCGTTTTCAAGCCTTTGTAAAGAAGAAGATGAGC
AGTTCAGTTGTTAGAAGGCTTGGAATTCCAGAGTGCATATTGCTTGTAACTCAGCGGATTACCAAGTACCCAGTTTTATTCCAAAGAATATTGCAGTGTA
CCAAAGACAATGAAGTGGAGCAGGAAGATCTAGCACAGTCCTTGAGCCTGGTGAAGGATGTGATTGGAGCTGTAGACAGCAAAGTGGCAAGTTATGAAAA
GAAAGTGCGTCTCAATGAGATTTATACAAAGACAGATAGCAAGTCAATCATGAGGATGAAGAGTGGTCAGATGTTTGCCAAGGAAGATTTGAAACGGAAG
AAGCTTGTACGTGATGGGAGTGTGTTTCTGAAGAATGCAGCAGGAAGGTTGAAAGAGGTTCAAGCAGTTCTTCTCACTGACATTTTAGTTTTCCTTCAAG
AAAAAGACCAGAAGTACATCTTTGCATCATTGGACCAGAAGTCAACAGTGATCTCTTTAAAGAAGCTGATTGTGAGAGAAGTGGCACATGAGGAGAAAGG
TTTATTCCTGATCAGCATGGGGATGACAGATCCAGAGATGGTAGAAGTCCATGCCAGCTCCAAAGAGGAACGAAACAGCTGGATTCAGATCATTCAGGAC
ACAATCAACACCCTGAACAGAGATGAAGATGAAGGAATTCCTAGTGAGAATGAGGAAGAAAAGAAAATGTTGGACACCAGAGCCCGAGAATTAAAAGAAC
AACTTCACCAGAAGGACCAAAAAATCCTACTCTTGTTGGAAGAGAAGGAGATGATTTTCCGGGACATGGCTGAGTGCAGCACCCCTCTCCCAGAGGATTG
CTCCCCAACACATAGCCCTAGAGTTCTCTTCCGCTCCAACACAGAAGAGGCTCTCAAAGGAGGACCTTTAATGAAAAGTGCAATAAATGAGGTGGAGATC
CTTCAGGGTTTGGTGAGTGGAAATCTGGGAGGCACACTTGGGCCGACTGTCAGCAGCCCCATTGAGCAAGATGTGGTCGGTCCCGTTTCCCTGCCCCGGA
GAGCAGAGACCTTTGGAGGATTTGACAGCCATCAGATGAATGCTTCAAAAGGAGGCGAGAAGGAAGAGGGAGATGATGGCCAAGATCTTAGGAGAACGGA
ATCAGATAGTGGCCTAAAAAAGGGTGGAAATGCTAACCTGGTATTTATGCTTAAAAGAAACAGTGAGCAGGTTGTCCAGAGCGTTGTTCATCTCTACGAG
CTCCTCAGCGCTCTGCAGGGTGTGGTGCTGCAGCAGGACAGCTACATTGAGGACCAGAAACTGGTGCTGAGCGAGAGGGCGCTCACTCGCAGCTTGTCCC
GCCCGAGCTCCCTCATTGAGCAGGAGAAGCAGCGCAGCCTGGAGAAGCAGCGCCAGGACCTGGCCAACCTGCAGAAGCAGCAGGCCCAGTACCTCGAGGA
GAAGCGCAGGCGCGAGCGTGAGTGGGAAGCTCGTGAGAGGGAGCTGCGGGAGCGGGAGGCCCTCCTGGCCCAGCGCGAGGAGGAGGTGCAGCAGGGGCAG
CAGGACCTGGAAAAGGAGCGGGAGGAGCTCCAGCAGAAGAAGGGCACATACCAGTATGACCTGGAGCGACTGCGTGCTGCCCAGAAACAGCTTGAGAGGG
AACAGGAGCAGCTGCGCCGGGAGGCAGAGCGGCTCAGCCAGCGGCAGACAGAACGGGACCTGTGTCAGGTTTCCCATCCACATACCAAGCTGATGAGGAT
CCCATCGTTCTTCCCCAGTCCTGAGGAGCCCCCCTCGCCATCTGCACCTTCCATAGCCAAATCAGGGTCATTGGACTCAGAACTTTCAGTGTCCCCAAAA
AGGAACAGCATCTCTCGGACACACAAAGATAAGGGGCCTTTTCACATACTGAGTTCAACCAGCCAGACAAACAAAGGACCAGAAGGGCAGAGCCAGGCCC
CTGCGTCCACCTCTGCCTCTACCCGCCTGTTTGGGTTAACAAAGCCAAAGGAAAAGAAGGAGAAAAAAAAGAAGAACAAAACCAGCCGCTCTCAGCCCGG
TGATGGTCCCGCGTCAGAAGTATCAGCAGAGGGTGAAGAGATCTTCTGCTGACCCTCTTCCTCTCTGCTGAGGCAGCTGCCTCCTGATCCTGGCCAGCCC
ACCTCTCCTGCTGTCCCCGCGTGCACAAGTCTCTTACACTGGACGCCCACTGCTCCTCAGCGTCCAGTCCTCCTGGGCGGCCCCAGGTCCTGGACAATAA
GCAACAGATGATATTGAGTGTCGGGTGGGGAAGGAGGCCCAGACTCTGCTTCGGCCATGATTTGTGACTGCCCAGGACTCTCAGGTTGGGCTGGCCCTAC
TCAGGATTACACTGAAAGTAATGGCCTCGTAAGTACAGGTGATGGTTTTGGACACGTCAGGAATTCCTAAAGGCTGAAAGAGTGTATCCAAGTAAGGTCT
GAACCTCCGAATGCCTTTTATTTGGGGGAACACAAAACCAAACAGCAGATGTTTTGGACTTGATCTGTGTACGTACATGGGGACCTGTCTGCATATACAC
ACGGGGAATGCCAGAAGAAGGCCCAGTCTGCACCAGGCGTCTGGTCAACTTAGCACAAGGGCAGTGCCTGGACGGACCCGGAGCCCCCGCATATCAGCAG
TTCACCCAGTACTCCTCAGAGACTGGTTTCCCTCTAAACCCATCCCGGGCACATACCACCCGTGTTTTGCATGTATTTCTCATTTCATTTTAGGGATGAC
AAACATTTGTGAAACCAGTGAGAGAAGGCTTGATGTGTATAAAAGACGTGATGTGCACCACCTCGATCTCGGTGTTTCAGGCACTAAAGCAACAAAACAA
CCCATAGTATCTCATTCTGTCATCAGATCCAGAAGAAATATCCTGGTTTTCCAGCATGTTTACCCACATGTTTTGGCCATGGATAAAGTGAAGAGGCCTA
CTCACCATTATCCCTGCAGCGTGACACCTTTTGATTGTCACTGACCACTCAGAAGGGGCCACGGCCTCCTGGCTGTGTTCCTGAGCCCCCGTCGTGCCTC
TCCCAGACAGCAGCTGTCTGGCCCTTGCTGGGTGAGGGCACACCACTGCCAGGGGTCAGCCTCGCACCCAGGCCAGGCAGAAGCTGTGCTCTGAAGCTAG
GACAGCTGGCTGAGAAGTGGGTTCAGGCGAAGGGTGAAGCCATGTGTAGCAGTTCCTGCCAGTGCAGATCTGGAGAGGAGCTGGCCCGGAAGGCGTGGTT
GTGAAAGCGCCCTTCTTATGTTAGGAGGCCTTGGCAAAATTGGATTTCTTCAAAAATACATGTAAAGGTCTGTTGTTGAATTGTACTCTGCCCCTGGAAG
CAGATACAGATGGCTGCCTGCTGCTCGGCTTTGCTTTTGCTTTTCCCACCGTGTTTTCATCTTTGTTCACTTGAGGCTTTCCCCAGCTGGTGTGTGCAGG
ACAGTTCATGGTAATGTTGCCCTCTGAGGCCCCGTACACCAGAAGGGAGGCCCTGGAAAATTTTGTGCTTCCAACGTGGCCTTCAATTCTTGCTTTTTTG
CCCCTCGGAAGCATGGGGCTTTTGAGCACACTTAAAAAAAGAAAAATCTGTAACTTGGTGCTTATTGATGAATTGCAAGCTGGCCTTGCAGATGGAGATA
TTTATCTTTCAGTTTATTTGAAAGAGGTCTGGTTTAAAATTTGTAGCCTACATTTGTTTTATTTATTGTATTTGTGTGTTTGTGTTTGTTTTTTTTTAAG
GGTGAGCCAGGTCTAGCCCAACAGTCTAAACTATCCAGTCAATACCGAGTGAAGTGGCAGCCAGCACTGTTCACTCTGTGTCTTTTGAAGTGCCTTGAAG
GCCCAGATGAAATTTTAAAGGGAGGGGGTCCATGTCCTTCCCTCCCCCACCCCGCCTCATTCTTTAATCAAAGGATGTCTTCTCCCTTGTTTGAGAATGA
AGAAACTCGCCACCTCTGACCTACCTTTGCCTTTTTCTGTCATGGAGAATACTCACCCTTCAGAAACAGACCAAAGGCCAAAACCTGCTGATTTTTCTAT
TGAAAATATGTCCCCTTGCAAAGACCCTAAACAAAAAGTTAAGTTTCTTTCTTTCACCTATTTGTACAACTCCAAGTTACAGCTGAATCTGTCGTGACTT
TCCTGAGATCTACCCGGGGCTTGGCTGTCTGTTCTGGGCACTGGCTCCGAGTTCCCCTCCTGGGATTTGCAGGAGGGCAGTACTGAACCTGCATTCTTCT
CCTTGTAAATGTAGGCCGGGTGCCCCTGTTCTCCGGGTTTGGAACAATACGAGGTTGGTGCTGATGGGATTTACTTGCGTACGTGCTCTTCACAAAAACA
CCGTGGATGCTGAAGTTAGAGCACGTCGCCACAGAGCTTGACATCAATGTTAGAGGGTCTCTTACTCCCCGCCCAGCTGTGATGTTTCATCTGCTTTGGT
TGTTTTGGTGGTCTTTTTTAAAAATAGAGATTTCACATCTGCCCAGACCCCACTCAAAACGATTTGGTCAGGTTCTGGTTGGACAAGTTTAAAATCAAAG
TAGTGCCCGGAATTCCCTCAAACCACCCAACTTCATCCAGGAATACAGTCTGCAGTGCAGCAACAGAACCGCTTACCAAGAACTGTGCTTACATACCTTT
GTCATCTCTCTTCCCCCCTTGGAAGTTGTCCTCAGGGGGATTTGTTCCTGTCCTGGGGATTTACCTGGGATGGTGGCTGCCTGTGCTTTTGCTCATGGCC
TTGACAGTGCTCTAGTTGCTGGATCTAATGGCCTGTCTTGGTTTCTATCACATGAGAAGGGGTTGTTTTTTTGGGGTGACTCGGACTGAATTCCCCATAC
TGTTTCCACGCCGGGACACCATGTTCTCCATCAAGCTAAAGAAATCACGTGCCTGAAACTGTGCTTAAGTTTTGGGGGAAAGATGGAGTTCCTATCCAGA
GCCCCCAGATTTCCAGAATCGAGTGAGCTTCCTGGAAGGAGACTGCGTCTTCTCTCAATTCCAGTCATCTCAGTCGTTGTCGTTAGGTGACATGTGCACT
TTAAATGCTCTCATCGGTTGGCTTCATTTTCAAGACAATCAAATGTATTGACTGTGTTTTCTTCTTAGAAAATGGAGAGGGTTAAAAACATGCAAACTGC
CACTTTCAACCTTTGCCAGTATTCCCTCTACCCCCGTGAGAGCTATCTGGGGGGAAGAATCCTTACCAAGGTTTTTTTGGAAAGGTACGAATCTTAACTT
TTTTCCCCTTCTGTGTCTCAGGGTAATACTATTCAGAGTCGCCCCTTTGCTCATTTTCTCCCGTATTTGTTACCTTCCTGAGGCCTCAGTATTAGTCGTG
AGCACAAAGTTTTGAGACCTTTGGCGTTGTTTCTTGATGTGGGAGGGGAGGTGTTAGTGCATGCAAGGGTTGAACTAGATAGACCCTGCCTTAGTAGAGG
GTGGGACTATAACCTTAGAGGCCAGAACTTGATCCAGAAGTTGCTGTCCACAGAAGTGCTTTCTATTTCATCATTTTTGTTTCTAGGGCTCTTTTTCTGT
AGCCAGGTCTTCCCAAGGATTTTAGTATTTGCATTGGAGTTGAGGTTTACTCTAATGATGGTGGCCCAGCTGTGCCCAGAGGACAGCCAGGCAGGCCCTG
GGAGGGAGTTTAGAAAGACAGTCCTGGTGAATGGGCTTCAAGTGGTCACAAAGAGGGTGGCTGTGAGGTGACCCCAGACACTGCAGAACGATGTGCACCC
TCTGCGTTTTGGATGTCCTTGGAATGTGGGAGCCTAGAAATAACCCTGTGGATGGAATTGGGGCAGCGGCTGCTGGAGATCTGTGTGCCTTGCCTTCCTT
CAGCAGGACCGTCTAGGTGCGCAGCCACCTATGGATGCGTCCCAGCCAGCCCCGTCGCTCTCGTCCATCCTCAGAGACAAAGAAGAGGGCAGGGAGTTTG
GGCTTGGTTTTGAACTTTCCTTTCAATGTAGCAAAGCATTCCTAGTTAACCAGAGCCTTGGAATCTACTGCCTGCTGGCCAGGCTTTAAAATGAAAAGTG
TTTTAATGCTGCCATAAAAGGGAGGCGGGGGGGAGGAAGGGAAAATAAAGGCATCTTTCCAAGTACTCATCTAATTTAATTGTCAAAAGATTGATAGGCC
ATGAATTACTTCTCCATCTCACTAAGGGTTAAAGGCGTGCAACCCCCCACTGGCTGTGTCCCCTGCCACCGAAGTGAGTGACCTGCCCTACAACCAGGTG
GGACCACCTGTGCTGCAGTCCGGAGGGGCTTCTGCAGGAAGCACTCACCCCCCACACCTTCCCCGGCCTGAGCTTCCCCTACCTTTCGTCACCACCTGAG
GGCATGAGCACAGGCCATGGGGCGTGCCTGGTGAGTCTGCCTGTGGTTCAGGCTTAGCCTGTGGTCTCCTGTGTGCTGCTGCCCGCATGGGATGCGCAGG
GGAGGCGTGGGGATCCGCAGGAGGGTGGTTGGGATACACCGGATACCTCTGCTCTCATTGCTTGTTTGCAAATGCTCTATGGACATTTGTGTGCTAAATC
CTATTAAATAAAAAAGACGGGTTAAAACCCAGATGCTGTATATTCATTTGTAATTATGTATAAAGTGAAGCAGTTTTAAACTGTAAAGATTTTTTTCAGT
GTGTTTTCTCGAATTTTGCCACAACATACTGGCTTCGTATTTTATTTATCTTTCTTTCTAGTTACCAGCTTCAGACCCTTGTAAAGTCTCCCTCAGCCCT
TTCAAAAAATAATAAATTTCCTGTGAAGTTCTGG
- AKAP13-F1 (forward primer)
- AKAP13-R1 (reverse primer)
- Single exon skipping
Frame 0
AKRANPHPFVLQLETINFVQTLHVNRTQ*LLVAIWLQNCVIT*LASPKAPQQGNPAHKIHPMPPTVK
THRLIQSPLTL*GIPRNVRIFVLSKWWITKANE
KM*N*INL*QICLRWFHIHIQLSLKWRKNWCQT
RQ*YQTVLSLWQTVQAVNQ*PRMTHFLLSPPRKK
REQQLLNYIQLQIIEMAQMEIRMSLIRGH*KTG
Q*ACPHPPLLQSFSTGWGIPVSQDLVESMRVPP
LQQSQKL*ISRGTLTLPCKVWVRPLWL*IQF*LK
KENFWWFQKALQLRNKIRIKR*PVPLLRKMLSL
QELCRKSREHHLLDKILNNFMKNQSQLTVPRTK
HFS*VIHRVHPLPFLRQKLNITRKWPHKSHC*LK
VGLPRAWCHQEQVWPQSQGRKPWGQSTTAPLCC
HVCCQMGLMGPMLLTAVSLLLWMLE*RTLNPRE
KLVPVR*VEM*RWMLQGLMLYKVWLSPEERIYHT
TPKTS*FQTSC*AKRRMPF*VCQWLYRTKL*LT
HRELEPQR*YLLIGRKGSWREQTTAVPWVTLRK
PK*TMKHILSYCSLLPRSSPQTWSSQPMMMGPQL
V*GKSCEPRLQAGKGALPLYLAWSLPRTHLCLR
GQT**RRLPAV*WMLSSNKSRPLEHCLLRGRPV
TCHCPALSWVLSLKD*RVLLQKK*VLSHLGRAYQ
WAVLLRKPRGALQDVLLEGRSQRRSFYLSRGLS
QQQKCQT*KLKMKWILEQVQFLKKWL*GA*LLH
*R*SKAQ*PRR*TEKTGVQ*SHALMQHLFWLPSR
AQNVRTSWMLDWAESVPQNKVYLKENLGVILTS
FTHPVMTWTASSSQSQRKSIWPVISPDPVHPPM
TRLHWTDILLMAVMCLSPRF*SQTGQEIGKALMD
STAMGWELRVEKVRVSLLTQATWRRRRWTVSLK
CLQTALS*GAPCALFLPSGGTAGGLGKMQPAMQ
K*TTGVSV*KA*QEELVSETSHPHL*K*ALQMPK
SSDTHSVVRNGLTLWCHFQKRIWSQTRENIGCL
ISRYVTDLSSRDLITVHQPFPLH*QNPSH**QS
AILDWTIHGPSTVPSTIPVLI*LRV*QKRTIISC
HIAPPRKILNGRVEQKSVVHSATSRIKCLAARR
AKKRKKKKIRLRRRRKILKTRRKIRRLSTGTLS
VPFLLWVPSAVASV*SPSPTKMPILVQIAVLLST
KAAEKV*PPVQRSK*SSPKGAFRHMTHHHCPRS
L*ETSPHSPRSVLGPQSSWWMKPLPPQYLPIDD
PSRVSRSPKVSPYRTLLELAMMRTCQTPGNSCLI
QQTH*IKSARSMSQQNHLLMRVQT*MKDNYWET
LRLSPNSWKQSLGVG**TASF*NSKRKMWSNGK
K*YMS*CRQSFIMSALSRS*VVCTARG*WRICFL
SSRW*KSCSPVWMS*SVSIANSSRGFWSGRRSL
WWIKVKRTFSSRG*GMCL*ISFQVRMQNV*RRH
MASFVGNITSL*TTSKTFMPRISVFKPL*RRR*A
VQLLEGLEFQSAYCL*LSGLPSTQFYSKEYCSV
PKTMKWSRKI*HSP*AW*RM*LEL*TAKWQVMK
RKCVSMRFIQRQIASQS*G*RVVRCLPRKI*NGR
SLYVMGVCF*RMQQEG*KRFKQFFSLTF*FSFK
KKTRSTSLHHWTRSQQ*SL*RS*L*EKWHMRRK
VYS*SAWG*QIQRW*KSMPAPKRNETAGFRSFRT
QSTP*TEMKMKEFLVRMRKKRKCWTPEPEN*KN
NFTRRTKKSYSCWKRRR*FSGTWLSAAPLSQRI
APQHIALEFSSAPTQKRLSKEDL**KVQ*MRWRS
FRVW*VEIWEAHLGRLSAAPLSKMWSVPFPCPG
EQRPLEDLTAIR*MLQKEARRKREMMAKILGER
NQIVA*KRVEMLTWYLCLKETVSRLSRALFISTS
SSALCRVWCCSRTATLRTRNWC*ARGRSLAACP
ARAPSLSRRSSAAWRSSARTWPTCRSSRPSTSR
RSAGASVSGKLVRGSCGSGRPSWPSARRRCSRGS
RTWKRSGRSSSRRRAHTSMTWSDCVLPRNSLRG
NRSSCAGRQSGSASGRQNGTCVRFPIHIPS**G
SHRSSPVLRSPPRHLHLP*PNQGHWTQNFQCPQK
GTASLGHTKIRGLFTY*VQPARQTKDQKGRARP
LRPPLPLPACLG*QSQRKRRRKKRRTKPAALSP
VMVPRQKYQQRVKRSSADPLPLC*GSCLLILASP
PLLLSPRAQVSYTGRPLLLSVQSSWAAPGPGQ*
ATDDIECRVGKEAQTLLRP*FVTAQDSQVGLAL
LRITLKVMAS*VQVMVLDTSGIPKG*KSVSK*GL
NLRMPFIWGNTKPNSRCFGLDLCTYMGTCLHIH
TGNARRRPSLHQASGQLSTRAVPGRTRSPRISA
VHPVLLRDWFPSKPIPGTYHPCFACISHFILGMT
NICETSERRLDVYKRRDVHHLDLGVSGTKATKQ
PIVSHSVIRSRRNILVFQHVYPHVLAMDKVKRP
THHYPCSVTPFDCH*PLRRGHGLLAVFLSPRRAS
PRQQLSGPCWVRAHHCQGSASHPGQAEAVL*S*
DSWLRSGFRRRVKPCVAVPASADLERSWPGRRG
CESALLMLGGLGKIGFLQKYM*RSVVELYSAPGS
RYRWLPAARLCFCFSHRVFIFVHLRLSPAGVCR
TVHGNVAL*GPVHQKGGPGKFCASNVAFNSCFF
APRKHGAFEHT*KKKNL*LGAY**IASWPCRWRY
LSFSLFERGLV*NL*PTFVLFIVFVCLCLFFFK
GEPGLAQQSKLSSQYRVKWQPALFTLCLLKCLE
GPDEILKGGGPCPSLPHPASFFNQRMSSPLFENE
ETRHL*PTFAFFCHGEYSPFRNRPKAKTC*FFY
*KYVPLQRP*TKS*VSFFHLFVQLQVTAESVVT
FLRSTRGLAVCSGHWLRVPLLGFAGGQY*TCILL
LVNVGRVPLFSGFGTIRGWC*WDLLAYVLFTKT
PWMLKLEHVATELDINVRGSLTPRPAVMFHLLW
LFWWSFLKIEISHLPRPHSKRFGQVLVGQV*NQS
SARNSLKPPNFIQEYSLQCSNRTAYQELCLHTF
VISLPPLEVVLRGICSCPGDLPGMVAACAFAHG
LDSALVAGSNGLSWFLSHEKGLFFWGDSD*IPHT
VSTPGHHVLHQAKEITCLKLCLSFGGKMEFLSR
APRFPESSELPGRRLRLLSIPVISVVVVR*HVH
FKCSHRLASFSRQSNVLTVFSS*KMERVKNMQTA
TFNLCQYSLYPRESYLGGRILTKVFLERYES*L
FSPSVSQGNTIQSRPFAHFLPYLLPS*GLSISR
EHKVLRPLALFLDVGGEVLVHARVELDRPCLSRG
WDYNLRGQNLIQKLLSTEVLSISSFLFLGLFFC
SQVFPRILVFALELRFTLMMVAQLCPEDSQAGP
GREFRKTVLVNGLQVVTKRVAVR*PQTLQNDVHP
LRFGCPWNVGA*K*PCGWNWGSGCWRSVCLAFL
QQDRLGAQPPMDASQPAPSLSSILRDKEEGREF
GLGFELSFQCSKAFLVNQSLGIYCLLARL*NEKC
FNAAIKGRRGGGRENKGIFPSTHLI*LSKD**A
MNYFSISLRVKGVQPPTGCVPCHRSE*PALQPG
GTTCAAVRRGFCRKHSPPTPSPA*ASPTFRHHLR
A*AQAMGRAW*VCLWFRLSLWSPVCCCPHGMRR
GGVGIRRRVVGIHRIPLLSLLVCKCSMDICVLN
PIK*KRRVKTQMLYIHL*LCIK*SSFKL*RFFSV
CFLEFCHNILASYFIYLSF*LPASDPCKVSLSP
FKK**ISCEVL
Frame 1
PKGQILTHLFYNWRR*TLCRLCMSTEHSDF*WRFGCKTV**HS*RVRKHHSKATQLTRSTRCLPL*
RPTGSYSHL*PCKGYPGTCGFLSFQSGG*QRPTK
RCETR*TFNKYA*GGFTSTSSCP*NGERTGARP
GSNIRQYFLSGKQSRQ*ISNQG*RTFFCPLPER
KGNSNS*TTYSYRL*RWPRWKFE*A*YAATRRQG
SRPVHILHCCRASARDGEYQSHRTWWRA*GSRP
SSNPRSSEYQGEH*LFPAKCG*GHFGFRFSFD*
RRKTSGGFRKLCSSGTR*G*SGDLFLY*GKCSLF
RNFAGRAENTTSWTRYSTIS*KINLS*LCQGQS
TSAK*FTGCILCLS*GRN*T*QGSGPTSLTADS
RWGCPEPGATRSKSGHRVKAGSLGGRAQQLRSVA
MSVARWV*WVRCS*LQSAFSSGCWSEEHSIPGK
N*CL*GEWRCDGGCYRG*CSTRYG*AQKREYIT
QHPRHPDSKRLVEPREECRSRFASGSTGQSCD*P
TGSWNPRDDTS*LGEREAGGSRPQLYHG*R*GS
PNRR*STSCPTAACCQGAPHRHGALSP**WGPS
WCEGSHASPAFRQGKEHSLSTLHGLCPGRTSA*G
GRLDRGGCQPYSGCCHRTSQGRWSTAY*GGGLS
HVTVQP*VGSSH*RTRECFYRKSEYFPTWGEPT
NGQYS*GSHGEPCRMFCWKGGAREDHFTCPGA*A
SSRNARRES*R*SGF*SKFNF*RSGCREHSCYT
EDEARPNDPGDKPRKLVYNRAMP*CSISSGFQA
EPRM*ELPGCWTGQRVYLKTRCT*KRIWE*F*PL
SLTQ**HGQHHLPKARGRAFGL*YHRIQFIHR*
HGFTGPTFFSWQ*CVSLPDFKAKQVKRSAKP*W
ILQPWDGS*GSRK*E*AC*PRRRGGGGDGQYH*S
ACKLLCPKELHALSFSLPEAQLGAWEKCSQRCR
NEPPEFQSRRLDRRSWCRKQAILISRSKLCKCR
RAQTPIQW*GTG*LFGVTFRRGSGVRPERT*DV*
SADMSQI*AAGI*LLYISHFLSIDKIHLINDNQ
PSWIGQFTALPQYLPQYQC*SD*EYNRREL*FP
AT*PLQERF*MEEWNKSQSYIQLHQE*NV*QQEE
QRKGKRKR*D*GEGERF*RQGER*EDCQRAHFQ
FHSCCGSHQL*PVYEALHQQRCLYLCKLQCFCP
QRLPRKSSLLCKGQNEAAQREPSGT*HIITAHGH
YEKQALTAQGASSVRSPPGG*NRYHPNICQ*TI
PAECLALQKCLHTEHYWSWQ**EHVKHLEIPVS
FNRLTK*NQQGQ*VNRITY**GYRHE*RTTTGRL
*D*VQTAGSRVLESDNRQQVSKTAKERCGQTAR
SNI*VDADRVSSCPHSQDHEWCVQPGDDGGSAF
*AADGRKAVPLFG*ADQYP*PILPEDSGAEEGVS
GG*K*KELSHQEDRGCACKSVFR*ECRTFKEDI
WQVLWAT*PVCKLLQRPLCQG*AFSSLCKEEDE
QFSC*KAWNSRVHIACNSADYQVPSFIPKNIAVY
QRQ*SGAGRSSTVLEPGEGCDWSCRQQSGKL*K
ESASQ*DLYKDR*QVNHEDEEWSDVCQGRFETE
EACT*WECVSEECSRKVERGSSSSSH*HFSFPSR
KRPEVHLCIIGPEVNSDLFKEADCERSGT*GER
FIPDQHGDDRSRDGRSPCQLQRGTKQLDSDHSG
HNQHPEQR*R*RNS**E*GRKENVGHQSPRIKRT
TSPEGPKNPTLVGREGDDFPGHG*VQHPSPRGL
LPNT*P*SSLPLQHRRGSQRRTFNEKCNK*GGD
PSGFGEWKSGRHTWADCQQPH*ARCGRSRFPAPE
SRDLWRI*QPSDECFKRRREGRGR*WPRS*ENG
IR*WPKKGWKC*PGIYA*KKQ*AGCPERCSSLR
APQRSAGCGAAAGQLH*GPETGAEREGAHSQLVP
PELPH*AGEAAQPGEAAPGPGQPAEAAGPVPRG
EAQARA*VGSS*EGAAGAGGPPGPARGGGAAGA
AGPGKGAGGAPAEEGHIPV*PGATACCPETA*EG
TGAAAPGGRAAQPAADRTGPVSGFPSTYQADED
PIVLPQS*GAPLAICTFHSQIRVIGLRTFSVPK
KEQHLSDTQR*GAFSHTEFNQPDKQRTRRAEPGP
CVHLCLYPPVWVNKAKGKEGEKKEEQNQPLSAR
*WSRVRSISRG*RDLLLTLFLSAEAAAS*SWPA
HLSCCPRVHKSLTLDAHCSSASSPPGRPQVLDNK
QQMILSVGWGRRPRLCFGHDL*LPRTLRLGWPY
SGLH*K*WPRKYR*WFWTRQEFLKAERVYPSKV
*TSECLLFGGTQNQTADVLDLICVRTWGPVCIYT
RGMPEEGPVCTRRLVNLAQGQCLDGPGAPAYQQ
FTQYSSETGFPLNPSRAHTTRVLHVFLISF*G*
QTFVKPVREGLMCIKDVMCTTSISVFQALKQQNN
P*YLILSSDPEEISWFSSMFTHMFWPWIK*RGL
LTIIPAA*HLLIVTDHSEGATASWLCS*APVVP
LPDSSCLALAG*GHTTARGQPRTQARQKLCSEAR
TAG*EVGSGEG*SHV*QFLPVQIWRGAGPEGVV
VKAPFLC*EALAKLDFFKNTCKGLLLNCTLPLE
ADTDGCLLLGFAFAFPTVFSSLFT*GFPQLVCAG
QFMVMLPSEAPYTRREALENFVLPTWPSILAFL
PLGSMGLLSTLKKRKICNLVLIDELQAGLADGD
IYLSVYLKEVWFKICSLHLFYLLYLCVCVCFFLR
VSQV*PNSLNYPVNTE*SGSQHCSLCVF*SALK
AQMKF*REGVHVLPSPTPPHSLIKGCLLPCLRM
KKLATSDLPLPFSVMENTHPSETDQRPKPADFSI
ENMSPCKDPKQKVKFLSFTYLYNSKLQLNLS*L
S*DLPGAWLSVLGTGSEFPSWDLQEGSTEPAFF
SL*M*AGCPCSPGLEQYEVGADGIYLRTCSSQKH
RGC*S*STSPQSLTSMLEGLLLPAQL*CFICFG
CFGGLF*K*RFHICPDPTQNDLVRFWLDKFKIK
VVPGIPSNHPTSSRNTVCSAATEPLTKNCAYIPL
SSLFPPWKLSSGGFVPVLGIYLGWWLPVLLLMA
LTVL*LLDLMACLGFYHMRRGCFFGVTRTEFPI
LFPRRDTMFSIKLKKSRA*NCA*VLGERWSSYPE
PPDFQNRVSFLEGDCVFSQFQSSQSLSLGDMCT
LNALIGWLHFQDNQMY*LCFLLRKWRGLKTCKL
PLSTFASIPSTPVRAIWGEESLPRFFWKGTNLNF
FPLLCLRVILFRVAPLLIFSRICYLPEASVLVV
STKF*DLWRCFLMWEGRC*CMQGLN*IDPALVE
GGTITLEART*SRSCCPQKCFLFHHFCF*GSFSV
ARSSQGF*YLHWS*GLL**WWPSCAQRTARQAL
GGSLERQSW*MGFKWSQRGWL*GDPRHCRTMCT
LCVLDVLGMWEPRNNPVDGIGAAAAGDLCALPSF
SRTV*VRSHLWMRPSQPRRSRPSSETKKRAGSL
GLVLNFPFNVAKHS*LTRALESTACWPGFKMKS
VLMLP*KGGGGEEGKIKASFQVLI*FNCQKIDRP
*ITSPSH*GLKACNPPLAVSPATEVSDLPYNQV
GPPVLQSGGASAGSTHPPHLPRPELPLPFVTT*
GHEHRPWGVPGESACGSGLACGLLCAAARMGCAG
EAWGSAGGWLGYTGYLCSHCLFANALWTFVC*I
LLNKKDGLKPRCCIFICNYV*SEAVLNCKDFFQ
CVFSNFATTYWLRILFIFLSSYQLQTLVKSPSAL
SKNNKFPVKFW
Frame 2
QKGKSSPICSTTGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCE
DPQAHTVTSDPVRDTQERADFCPFKVVDNKGQR
KDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQ
AVISDSTFSLANSPGSESVTKDDALSFVPSQKE
KGTATPELHTATDYRDGPDGNSNEPDTRPLEDR
AVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAP
PAIPEALNIKGNTDSSLQSVGKATLALDSVLTE
EGKLLVVSESSAAQEQDKDKAVTCSSIKENALS
SGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKA
LQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQ
GGAAQSLVPPGASLATESRQEALGAEHNSSALL
PCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGK
TSACEVSGDVTVDVTGVNALQGMAEPRRENISH
NTQDILIPNVLLSQEKNAVLGLPVALQDKAVTD
PQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEA
QIDDEAHPVLLQPVAKELPTDMELSAHDDGAPA
GVREVMRAPPSGRERSTPSLPCMVSAQDAPLPK
GADLIEEAASRIVDAVIEQVKAAGALLTEGEACH
MSLSSPELGPLTKGLESAFTEKVSTFPPGESLP
MGSTPEEATGSLAGCFAGREEPEKIILPVQGPE
PAAEMPDVKAEDEVDFRASSISEEVAVGSIAATL
KMKQGPMTQAINRENWCTIEPCPDAASLLASKQ
SPECENFLDVGLGRECTSKQGVLKRESGSDSDL
FHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDD
TASLDRHSSHGSDVSLSQILKPNRSRDRQSLDG
FYSHGMGAEGRESESEPADPGDVEEEEMDSITE
VPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAE
MNHRSFSLEGLTGGAGVGNKPSSSLEVSSANAE
ELRHPFSGEERVDSLVSLSEEDLESDQREHRMF
DQQICHRSKQQGFNYCTSAISSPLTKSISLMTIS
HPGLDNSRPFHSTFHNTSANLTESITEENYNFL
PHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKK
SKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFS
SIPVVGPISCSQCMKPFTNKDAYTCANCSAFVH
KGCRESLASCAKVKMKQPKGSLQAHDTSSLPTV
IMRNKPSQPKERPRSAVLLVDETATTPIFANRRS
QQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH
STDSLNKISKVNESTESLTDEGTDMNEGQLLGD
FEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQE
VIYELMQTEFHHVRTLKIMSGVYSQGMMADLLF
EQQMVEKLFPCLDELISIHSQFFQRILERKKES
LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTY
GKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMS
SSVVRRLGIPECILLVTQRITKYPVLFQRILQC
TKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEK
KVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRK
KLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ
EKDQKYIFASLDQKSTVISLKKLIVREVAHEEKG
LFLISMGMTDPEMVEVHASSKEERNSWIQIIQD
TINTLNRDEDEGIPSENEEEKKMLDTRARELKE
QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDC
SPTHSPRVLFRSNTEEALKGGPLMKSAINEVEI
LQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPR
RAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTE
SDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYE
LLSALQGVVLQQDSYIEDQKLVLSERALTRSLS
RPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEE
KRRREREWEARERELREREALLAQREEEVQQGQ
QDLEKEREELQQKKGTYQYDLERLRAAQKQLER
EQEQLRREAERLSQRQTERDLCQVSHPHTKLMRI
PSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPK
RNSISRTHKDKGPFHILSSTSQTNKGPEGQSQA
PASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPG
DGPASEVSAEGEEIFC*PSSSLLRQLPPDPGQP
TSPAVPACTSLLHWTPTAPQRPVLLGGPRSWTI
SNR*Y*VSGGEGGPDSASAMICDCPGLSGWAGPT
QDYTESNGLVSTGDGFGHVRNS*RLKECIQVRS
EPPNAFYLGEHKTKQQMFWT*SVYVHGDLSAYT
HGECQKKAQSAPGVWST*HKGSAWTDPEPPHISS
SPSTPQRLVSL*THPGHIPPVFCMYFSFHFRDD
KHL*NQ*EKA*CV*KT*CAPPRSRCFRH*SNKT
THSISFCHQIQKKYPGFPACLPTCFGHG*SEEAY
SPLSLQRDTF*LSLTTQKGPRPPGCVPEPPSCL
SQTAAVWPLLGEGTPLPGVSLAPRPGRSCALKL
GQLAEKWVQAKGEAMCSSSCQCRSGEELARKAWL
*KRPSYVRRPWQNWISSKIHVKVCC*IVLCPWK
QIQMAACCSALLLLFPPCFHLCSLEAFPSWCVQ
DSSW*CCPLRPRTPEGRPWKILCFQRGLQFLLFC
PSEAWGF*AHLKKEKSVTWCLLMNCKLALQMEI
FIFQFI*KRSGLKFVAYICFIYCICVFVFVFF*
G*ARSSPTV*TIQSIPSEVAASTVHSVSFEVP*R
PR*NFKGRGSMSFPPPPRLIL*SKDVFSLV*E*
RNSPPLTYLCLFLSWRILTLQKQTKGQNLLIFL
LKICPLAKTLNKKLSFFLSPICTTPSYS*ICRDF
PEIYPGLGCLFWALAPSSPPGICRRAVLNLHSS
PCKCRPGAPVLRVWNNTRLVLMGFTCVRALHKN
TVDAEVRARRHRA*HQC*RVSYSPPSCDVSSALV
VLVVFFKNRDFTSAQTPLKTIWSGSGWTSLKSK
*CPEFPQTTQLHPGIQSAVQQQNRLPRTVLTYL
CHLSSPLGSCPQGDLFLSWGFTWDGGCLCFCSWP
*QCSSCWI*WPVLVSIT*EGVVFLG*LGLNSPY
CFHAGTPCSPSS*RNHVPETVLKFWGKDGVPIQ
SPQISRIE*ASWKETASSLNSSHLSRCR*VTCAL
*MLSSVGFIFKTIKCIDCVFFLENGEG*KHANC
HFQPLPVFPLPP*ELSGGKNPYQGFFGKVRILT
FFPFCVSG*YYSESPLCSFSPVFVTFLRPQY*S*
AQSFETFGVVS*CGRGGVSACKG*TR*TLP**R
VGL*P*RPELDPEVAVHRSAFYFIIFVSRALFL
*PGLPKDFSICIGVEVYSNDGGPAVPRGQPGRPW
EGV*KDSPGEWASSGHKEGGCEVTPDTAERCAP
SAFWMSLECGSLEITLWMELGQRLLEICVPCLP
SAGPSRCAATYGCVPASPVALVHPQRQRRGQGVW
AWF*TFLSM*QSIPS*PEPWNLLPAGQALK*KV
F*CCHKREAGGRKGK*RHLSKYSSNLIVKRLIG
HELLLHLTKG*RRATPHWLCPLPPK*VTCPTTRW
DHLCCSPEGLLQEALTPHTFPGLSFPYLSSPPE
GMSTGHGACLVSLPVVQA*PVVSCVLLPAWDAQ
GRRGDPQEGGWDTPDTSALIACLQMLYGHLCAKS
Y*IKKTG*NPDAVYSFVIMYKVKQF*TVKIFFS
VFSRILPQHTGFVFYLSFFLVTSFRPL*SLPQP
FQKIINFL*SS
Sequence AKAP13.aAug05
TGAGTTGAAGTGGGGGAAATAGAGGAGTAAATCATTTCACGATGTGTGGTTAAGTGCTGCAGCTCAGGTAACCACCAGTACACAGAGGAAGGGCGGTTTCTGGAGACAGGGCGGAGAGGAGACCGTGGGTGGGCATTTCCCAGAGCAGCCTCTGCCAGCCACCCTACTTTGATCACTTTGCCGCCGAGCAGCAGCGGCGG
TCAACCTCAGCCTCCCTTAGCAACCTGAGTGCCCCGTCCAGGAGCCTTACTATTGGTCTCATGCAGCGAGATGGGCAGTTCTGCCGTGCAATCCCAGCTC
GCAGTTCTTGCTCCGCGTGTACTCACGGGAGGACTCGCAGGCGTTACCGCCTTCCCGCGTGCCCCGCCCACCCTCCCGAGCGTCTTTCGGCGCATGCGCG
GACTGGAGCTGTGTGCAGGGCCAGCGCGGAGCCCGAGCAGCCGCGGTGAAGCGCCTGTGCTCTGCCGAGACTGCCGTGCCCATTGCTCGCCTCGGTCGCC
GCCGCTTTAGCCGCCTCCGGGGGAGCGGCCGCCTATTGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGC
CGCACGTGTCCTGGGTCATGAAACTTAATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGA
TGATGTAGTGTTTTACTTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTGCTCCTGGT
CATGATTGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACTTTCATTTCGTCCAGGATG
AAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTCTTGACCAGTCAGGACCCCCATCTGGGGA
TGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGTGGAATGTATTGGGGACAGATCAGAGTTTGCATGATGCT
GGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGTTGACGTGGTTCCTGTTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTA
TCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGGAGCGAGGCTATCACAAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGA
CTCCTGGAGCAGTTTATCCTATGAAATACCGTATGGAGACTGTTCTGTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCA
CATCATGAACACCCATTTCCTGGAGACGGTTGCACTGGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGG
ACAGTCTTATGCCCTTAATGATGACAGCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCA
GCGACTTTCTTCTTCTGAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCATAGTTGAG
GAGGAGAATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTGTGGACTCTGGAACTGTAT
CTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTGGAAACAGAAATGAAGAAACTGGAACAAA
ATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAGACTTGGTCATGGAGCCAGGCACAGCCCAGTATTCCTCT
GGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTGCAGGGGAAATGGAACATGGGCTCATGAACCCAGATGCCACTGTTTGGA
AGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTGAGAACTCTAATATTGGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGT
GGATAAAATCAGTGTTCCAAACTGTGCCCCTGCTGCCAGTTCCCTGGATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCC
ACTGAAAAAACAGCAGAAACGGAAACTTCACGAAGTCGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAG
ACAAGATTTCAGATGGATTAGAACCTTATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGA
TGTAATGCCACACCAGAACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTT
TGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACCACAG
CAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGGGATACCCAGGAACG
TGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAGATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACAT
CCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAGTAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAAT
CAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAAAAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCC
AGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGGGCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGG
AATACCAGTCTCACAGGACTTGGTGGAGAGCATGAGGGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGC
AAAGTGTGGGTAAGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAA
GGATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAA
CAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCAGAAA
CTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGTCTGGCCACAGAGTC
AAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAGATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAG
CCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTAGTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTA
ATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACACAACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGC
CGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGACCCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAG
CTGGAGGGAGCAGACCACAGCTGTACCATGGGTGACGCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGC
TCCCCACAGACATGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCC
CTCTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAA
CAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAGAGTG
CTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCAGGATGTTTTGCTGG
AAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCA
AGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTA
CAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCAAGCAGAGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTC
AAAACAAGGTGTACTTAAAAGAGAATCTGGGAGTGATTCTGACCTCTTTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAA
GAGCATTTGGCCTGTGATATCACCGGATCCAGTTCATCCACCGATGACACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCC
AGATTTTAAAGCCAAACAGGTCAAGAGATCGGCAAAGCCTTGATGGATTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGC
TGACCCAGGCGACGTGGAGGAGGAGGAGATGGACAGTATCACTGAAGTGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTC
CGGAGGCACAGCTGGGGGCCTGGGAAAAATGCAGCCAGCGATGCAGAAATGAACCACCGGAGTATGAGCTGGTGCCCCTCTGGTGTGCAGTACTCTGCTG
GCCTGAGTGCTGACTTTAATTACAGAAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGGTGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTC
TGCAAATGCCGAAGAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTGTCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAA
CATAGGATGTTTGATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTACATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCAT
TAATGACAATCAGCCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAATACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAA
CTATAATTTCCTGCCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAAGTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCT
AGCAGCAAGAAGAGCAAAGAAAAGGAAAAAGAAAAAGATAAGATTAAGGAGAAGGAGAAAGATTCTAAAGACAAGGAGAAAGATAAGAAGACTGTCAACG
GGCACACTTTCAGTTCCATTCCTGTTGTGGGTCCCATCAGCTGTAGCCAGTGTATGAAGCCCTTCACCAACAAAGATGCCTATACTTGTGCAAATTGCAG
TGCTTTTGTCCACAAAGGCTGCCGAGAAAGTCTAGCCTCCTGTGCAAAGGTCAAAATGAAGCAGCCCAAAGGGAGCCTTCAGGCACATGACACATCATCA
CTGCCCACGGTCATTATGAGAAACAAGCCCTCACAGCCCAAGGAGCGTCCTCGGTCCGCAGTCCTCCTGGTGGATGAAACCGCTACCACCCCAATATTTG
CCAATAGACGATCCCAGCAGAGTGTCTCGCTCTCCAAAAGTGTCTCCATACAGAACATTACTGGAGTTGGCAATGATGAGAACATGTCAAACACCTGGAA
ATTCCTGTCTCATTCAACAGACTCACTAAATAAAATCAGCAAGGTCAATGAGTCAACAGAATCACTTACTGATGAGGGAGTAGGTACAGACATGAATGAA
GGACAACTACTGGGAGACTTTGAGATTGAGTCCAAACAGCTGGAAGCAGAGTCTTGGAGTCGGATAATAGACAGCAAGTTTCTAAAACAGCAAAAGAAAG
ATGTGGTCAAACGGCAAGAAGTAATATATGAGTTGATGCAGACAGAGTTTCATCATGTCCGCACTCTCAAGATCATGAGTGGTGTGTACAGCCAGGGGAT
GATGGCGGATCTGCTTTTTGAGCAGCAGATGGTAGAAAAGCTGTTCCCCTGTTTGGATGAGCTGATCAGTATCCATAGCCAATTCTTCCAGAGGATTCTG
GAGCGGAAGAAGGAGTCTCTGGTGGATAAAAGTGAAAAGAACTTTCTCATCAAGAGGATAGGGGATGTGCTTGTAAATCAGTTTTCAGGTGAGAATGCAG
AACGTTTAAAGAAGACATATGGCAAGTTTTGTGGGCAACATAACCAGTCTGTAAACTACTTCAAAGACCTTTATGCCAAGGATAAGCGTTTTCAAGCCTT
TGTAAAGAAGAAGATGAGCAGTTCAGTTGTTAGAAGGCTTGGAATTCCAGAGTGCATATTGCTTGTAACTCAGCGGATTACCAAGTACCCAGTTTTATTC
CAAAGAATATTGCAGTGTACCAAAGACAATGAAGTGGAGCAGGAAGATCTAGCACAGTCCTTGAGCCTGGTGAAGGATGTGATTGGAGCTGTAGACAGCA
AAGTGGCAAGTTATGAAAAGAAAGTGCGTCTCAATGAGATTTATACAAAGACAGATAGCAAGTCAATCATGAGGATGAAGAGTGGTCAGATGTTTGCCAA
GGAAGATTTGAAACGGAAGAAGCTTGTACGTGATGGGAGTGTGTTTCTGAAGAATGCAGCAGGAAGGTTGAAAGAGGTTCAAGCAGTTCTTCTCACTGAC
ATTTTAGTTTTCCTTCAAGAAAAAGACCAGAAGTACATCTTTGCATCATTGGACCAGAAGTCAACAGTGATCTCTTTAAAGAAGCTGATTGTGAGAGAAG
TGGCACATGAGGAGAAAGGTTTATTCCTGATCAGCATGGGGATGACAGATCCAGAGATGGTAGAAGTCCATGCCAGCTCCAAAGAGGAACGAAACAGCTG
GATTCAGATCATTCAGGACACAATCAACACCCTGAACAGAGATGAAGATGAAGGAATTCCTAGTGAGAATGAGGAAGAAAAGAAAATGTTGGACACCAGA
GCCCGAGAATTAAAAGAACAACTTCACCAGAAGGACCAAAAAATCCTACTCTTGTTGGAAGAGAAGGAGATGATTTTCCGGGACATGGCTGAGTGCAGCA
CCCCTCTCCCAGAGGATTGCTCCCCAACACATAGCCCTAGAGTTCTCTTCCGCTCCAACACAGAAGAGGCTCTCAAAGGAGGACCTTTAATGAAAAGTGC
AATAAATGAGGTGGAGATCCTTCAGGGTTTGGTGAGTGGAAATCTGGGAGGCACACTTGGGCCGACTGTCAGCAGCCCCATTGAGCAAGATGTGGTCGGT
CCCGTTTCCCTGCCCCGGAGAGCAGAGACCTTTGGAGGATTTGACAGCCATCAGATGAATGCTTCAAAAGGAGGCGAGAAGGAAGAGGGAGATGATGGCC
AAGATCTTAGGAGAACGGAATCAGATAGTGGCCTAAAAAAGGGTGGAAATGCTAACCTGGTATTTATGCTTAAAAGAAACAGTGAGCAGGTTGTCCAGAG
CGTTGTTCATCTCTACGAGCTCCTCAGCGCTCTGCAGGGTGTGGTGCTGCAGCAGGACAGCTACATTGAGGACCAGAAACTGGTGCTGAGCGAGAGGGCG
CTCACTCGCAGCTTGTCCCGCCCGAGCTCCCTCATTGAGCAGGAGAAGCAGCGCAGCCTGGAGAAGCAGCGCCAGGACCTGGCCAACCTGCAGAAGCAGC
AGGCCCAGTACCTCGAGGAGAAGCGCAGGCGCGAGCGTGAGTGGGAAGCTCGTGAGAGGGAGCTGCGGGAGCGGGAGGCCCTCCTGGCCCAGCGCGAGGA
GGAGGTGCAGCAGGGGCAGCAGGACCTGGAAAAGGAGCGGGAGGAGCTCCAGCAGAAGAAGGGCACATACCAGTATGACCTGGAGCGACTGCGTGCTGCC
CAGAAACAGCTTGAGAGGGAACAGGAGCAGCTGCGCCGGGAGGCAGAGCGGCTCAGCCAGCGGCAGACAGAACGGGACCTGTGTCAGGTTTCCCATCCAC
ATACCAAGCTGATGAGGATCCCATCGTTCTTCCCCAGTCCTGAGGAGCCCCCCTCGCCATCTGCACCTTCCATAGCCAAATCAGGGTCATTGGACTCAGA
ACTTTCAGTGTCCCCAAAAAGGAACAGCATCTCTCGGACACACAAAGATAAGGGGCCTTTTCACATACTGAGTTCAACCAGCCAGACAAACAAAGGACCA
GAAGGGCAGAGCCAGGCCCCTGCGTCCACCTCTGCCTCTACCCGCCTGTTTGGGTTAACAAAGCCAAAGGAAAAGAAGGAGAAAAAAAAGAAGAACAAAA
CCAGCCGCTCTCAGCCCGGTGATGGTCCCGCGTCAGAAGTATCAGCAGAGGGTGAAGAGATCTTCTGCTGACCCTCTTCCTCTCTGCTGAGGCAGCTGCC
TCCTGATCCTGGCCAGCCCACCTCTCCTGCTGTCCCCGCGTGCACAAGTCTCTTACACTGGACGCCCACTGCTCCTCAGCGTCCAGTCCTCCTGGGCGGC
CCCAGGTCCTGGACAATAAGCAACAGATGATATTGAGTGTCGGGTGGGGAAGGAGGCCCAGACTCTGCTTCGGCCATGATTTGTGACTGCCCAGGACTCT
CAGGTTGGGCTGGCCCTACTCAGGATTACACTGAAAGTAATGGCCTCGTAAGTACAGGTGATGGTTTTGGACACGTCAGGAATTCCTAAAGGCTGAAAGA
GTGTATCCAAGTAAGGTCTGAACCTCCGAATGCCTTTTATTTGGGGGAACACAAAACCAAACAGCAGATGTTTTGGACTTGATCTGTGTACGTACATGGG
GACCTGTCTGCATATACACACGGGGAATGCCAGAAGAAGGCCCAGTCTGCACCAGGCGTCTGGTCAACTTAGCACAAGGGCAGTGCCTGGACGGACCCGG
AGCCCCCGCATATCAGCAGTTCACCCAGTACTCCTCAGAGACTGGTTTCCCTCTAAACCCATCCCGGGCACATACCACCCGTGTTTTGCATGTATTTCTC
ATTTCATTTTAGGGATGACAAACATTTGTGAAACCAGTGAGAGAAGGCTTGATGTGTATAAAAGACGTGATGTGCACCACCTCGATCTCGGTGTTTCAGG
CACTAAAGCAACAAAACAACCCATAGTATCTCATTCTGTCATCAGATCCAGAAGAAATATCCTGGTTTTCCAGCATGTTTACCCACATGTTTTGGCCATG
GATAAAGTGAAGAGGCCTACTCACCATTATCCCTGCAGCGTGACACCTTTTGATTGTCACTGACCACTCAGAAGGGGCCACGGCCTCCTGGCTGTGTTCC
TGAGCCCCCGTCGTGCCTCTCCCAGACAGCAGCTGTCTGGCCCTTGCTGGGTGAGGGCACACCACTGCCAGGGGTCAGCCTCGCACCCAGGCCAGGCAGA
AGCTGTGCTCTGAAGCTAGGACAGCTGGCTGAGAAGTGGGTTCAGGCGAAGGGTGAAGCCATGTGTAGCAGTTCCTGCCAGTGCAGATCTGGAGAGGAGC
TGGCCCGGAAGGCGTGGTTGTGAAAGCGCCCTTCTTATGTTAGGAGGCCTTGGCAAAATTGGATTTCTTCAAAAATACATGTAAAGGTCTGTTGTTGAAT
TGTACTCTGCCCCTGGAAGCAGATACAGATGGCTGCCTGCTGCTCGGCTTTGCTTTTGCTTTTCCCACCGTGTTTTCATCTTTGTTCACTTGAGGCTTTC
CCCAGCTGGTGTGTGCAGGACAGTTCATGGTAATGTTGCCCTCTGAGGCCCCGTACACCAGAAGGGAGGCCCTGGAAAATTTTGTGCTTCCAACGTGGCC
TTCAATTCTTGCTTTTTTGCCCCTCGGAAGCATGGGGCTTTTGAGCACACTTAAAAAAAGAAAAATCTGTAACTTGGTGCTTATTGATGAATTGCAAGCT
GGCCTTGCAGATGGAGATATTTATCTTTCAGTTTATTTGAAAGAGGTCTGGTTTAAAATTTGTAGCCTACATTTGTTTTATTTATTGTATTTGTGTGTTT
GTGTTTGTTTTTTTTTAAGGGTGAGCCAGGTCTAGCCCAACAGTCTAAACTATCCAGTCAATACCGAGTGAAGTGGCAGCCAGCACTGTTCACTCTGTGT
CTTTTGAAGTGCCTTGAAGGCCCAGATGAAATTTTAAAGGGAGGGGGTCCATGTCCTTCCCTCCCCCACCCCGCCTCATTCTTTAATCAAAGGATGTCTT
CTCCCTTGTTTGAGAATGAAGAAACTCGCCACCTCTGACCTACCTTTGCCTTTTTCTGTCATGGAGAATACTCACCCTTCAGAAACAGACCAAAGGCCAA
AACCTGCTGATTTTTCTATTGAAAATATGTCCCCTTGCAAAGACCCTAAACAAAAAGTTAAGTTTCTTTCTTTCACCTATTTGTACAACTCCAAGTTACA
GCTGAATCTGTCGTGACTTTCCTGAGATCTACCCGGGGCTTGGCTGTCTGTTCTGGGCACTGGCTCCGAGTTCCCCTCCTGGGATTTGCAGGAGGGCAGT
ACTGAACCTGCATTCTTCTCCTTGTAAATGTAGGCCGGGTGCCCCTGTTCTCCGGGTTTGGAACAATACGAGGTTGGTGCTGATGGGATTTACTTGCGTA
CGTGCTCTTCACAAAAACACCGTGGATGCTGAAGTTAGAGCACGTCGCCACAGAGCTTGACATCAATGTTAGAGGGTCTCTTACTCCCCGCCCAGCTGTG
ATGTTTCATCTGCTTTGGTTGTTTTGGTGGTCTTTTTTAAAAATAGAGATTTCACATCTGCCCAGACCCCACTCAAAACGATTTGGTCAGGTTCTGGTTG
GACAAGTTTAAAATCAAAGTAGTGCCCGGAATTCCCTCAAACCACCCAACTTCATCCAGGAATACAGTCTGCAGTGCAGCAACAGAACCGCTTACCAAGA
ACTGTGCTTACATACCTTTGTCATCTCTCTTCCCCCCTTGGAAGTTGTCCTCAGGGGGATTTGTTCCTGTCCTGGGGATTTACCTGGGATGGTGGCTGCC
TGTGCTTTTGCTCATGGCCTTGACAGTGCTCTAGTTGCTGGATCTAATGGCCTGTCTTGGTTTCTATCACATGAGAAGGGGTTGTTTTTTTGGGGTGACT
CGGACTGAATTCCCCATACTGTTTCCACGCCGGGACACCATGTTCTCCATCAAGCTAAAGAAATCACGTGCCTGAAACTGTGCTTAAGTTTTGGGGGAAA
GATGGAGTTCCTATCCAGAGCCCCCAGATTTCCAGAATCGAGTGAGCTTCCTGGAAGGAGACTGCGTCTTCTCTCAATTCCAGTCATCTCAGTCGTTGTC
GTTAGGTGACATGTGCACTTTAAATGCTCTCATCGGTTGGCTTCATTTTCAAGACAATCAAATGTATTGACTGTGTTTTCTTCTTAGAAAATGGAGAGGG
TTAAAAACATGCAAACTGCCACTTTCAACCTTTGCCAGTATTCCCTCTACCCCCGTGAGAGCTATCTGGGGGGAAGAATCCTTACCAAGGTTTTTTTGGA
AAGGTACGAATCTTAACTTTTTTCCCCTTCTGTGTCTCAGGGTAATACTATTCAGAGTCGCCCCTTTGCTCATTTTCTCCCGTATTTGTTACCTTCCTGA
GGCCTCAGTATTAGTCGTGAGCACAAAGTTTTGAGACCTTTGGCGTTGTTTCTTGATGTGGGAGGGGAGGTGTTAGTGCATGCAAGGGTTGAACTAGATA
GACCCTGCCTTAGTAGAGGGTGGGACTATAACCTTAGAGGCCAGAACTTGATCCAGAAGTTGCTGTCCACAGAAGTGCTTTCTATTTCATCATTTTTGTT
TCTAGGGCTCTTTTTCTGTAGCCAGGTCTTCCCAAGGATTTTAGTATTTGCATTGGAGTTGAGGTTTACTCTAATGATGGTGGCCCAGCTGTGCCCAGAG
GACAGCCAGGCAGGCCCTGGGAGGGAGTTTAGAAAGACAGTCCTGGTGAATGGGCTTCAAGTGGTCACAAAGAGGGTGGCTGTGAGGTGACCCCAGACAC
TGCAGAACGATGTGCACCCTCTGCGTTTTGGATGTCCTTGGAATGTGGGAGCCTAGAAATAACCCTGTGGATGGAATTGGGGCAGCGGCTGCTGGAGATC
TGTGTGCCTTGCCTTCCTTCAGCAGGACCGTCTAGGTGCGCAGCCACCTATGGATGCGTCCCAGCCAGCCCCGTCGCTCTCGTCCATCCTCAGAGACAAA
GAAGAGGGCAGGGAGTTTGGGCTTGGTTTTGAACTTTCCTTTCAATGTAGCAAAGCATTCCTAGTTAACCAGAGCCTTGGAATCTACTGCCTGCTGGCCA
GGCTTTAAAATGAAAAGTGTTTTAATGCTGCCATAAAAGGGAGGCGGGGGGGAGGAAGGGAAAATAAAGGCATCTTTCCAAGTACTCATCTAATTTAATT
GTCAAAAGATTGATAGGCCATGAATTACTTCTCCATCTCACTAAGGGTTAAAGGCGTGCAACCCCCCACTGGCTGTGTCCCCTGCCACCGAAGTGAGTGA
CCTGCCCTACAACCAGGTGGGACCACCTGTGCTGCAGTCCGGAGGGGCTTCTGCAGGAAGCACTCACCCCCCACACCTTCCCCGGCCTGAGCTTCCCCTA
CCTTTCGTCACCACCTGAGGGCATGAGCACAGGCCATGGGGCGTGCCTGGTGAGTCTGCCTGTGGTTCAGGCTTAGCCTGTGGTCTCCTGTGTGCTGCTG
CCCGCATGGGATGCGCAGGGGAGGCGTGGGGATCCGCAGGAGGGTGGTTGGGATACACCGGATACCTCTGCTCTCATTGCTTGTTTGCAAATGCTCTATG
GACATTTGTGTGCTAAATCCTATTAAATAAAAAAGACGGGTTAAAACCCAGATGCTGTATATTCATTTGTAATTATGTATAAAGTGAAGCAGTTTTAAAC
TGTAAAGATTTTTTTCAGTGTGTTTTCTCGAATTTTGCCACAACATACTGGCTTCGTATTTTATTTATCTTTCTTTCTAGTTACCAGCTTCAGACCCTTG
TAAAGTCTCCCTCAGCCCTTTCAAAAAATAATAAATTTCCTGTGAAGTTCTGG
- AKAP13-F1 (forward primer)
- AKAP13-R1 (reverse primer)
- Single exon skipping
Frame 0
*VEVGEIEE*IISRCVVKCCSSGNHQYTEEGRFLETGRRGDRGWAFPRAASASHPTLITLPPSSSGG
QPQPPLAT*VPRPGALLLVSCSEMGSSAVQSQL
AVLAPRVLTGGLAGVTAFPRAPPTLPSVFRRMR
GLELCAGPARSPSSRGEAPVLCRDCRAHCSPRSP
PL*PPPGERPPIVFLRGEGEELSQLGPRGSPGS
RTCPGS*NLIHSKLPYMVIVLLQCCLLKRTKLK
MM*CFTWYFWVPPSVTVQVLGRSVLIHWRPLLLV
MIVVKQ*RCSSVLPKRAFPCLWWLKKTFISSRM
KRMMQLNS*QPVLEISRL*TLPVFLTSQDPHLG
M*IPLIRSWCWHSGT*SCPRSGMYWGQIRVCMML
ARERH*CILLCGWDC*G*RGSCCRSQVAAELSV
STTRKGRRL*AWPWSEAITSCTSF*PRRMLENQ
TPGAVYPMKYRMETVL*GIIESWTSIH*PLSLIH
IMNTHFLETVALDQFLNL*TSNSN**KQTSSRW
TVLCP***QHRILPVPQRQMASFFPVHRSPRTL
SDFLLLKRLRALSAAQGALLHRLKVPVICQA*LR
RRIQTVPVGRKIKAWKEKGKRWSQHLLWTLELY
LIKTAAFRACLIVE*RARKAFRPVETEMKKLEQ
NLLECPQTRSP*AVEMLCFRETWSWSQAQPSIPL
EVNWEAFQQQMSVPQTLQGKWNMGS*TQMPLFG
RMCFREGKVQRKDLRTLILAQLEPLTCTSQVSL
WIKSVFQTVPLLPVPWMVTNLLSLHLHLVMKKPP
LKKQQKRKLHEVVRRVLMLQ*IRILW*FQLLQK
TRFQMD*NLILS*QQA*VRQCHPQI*PFLGWKK
M*CHTRTQKQIHLMLKAKRANPHPFVLQLETINF
VQTLHVNRTQ*LLVAIWLQNCVIT*LASPKAPQ
QGNPAHKIHPMPPTVKTHRLIQSPLTL*GIPRN
VRIFVLSKWWITKANEKM*N*INL*QICLRWFHI
HIQLSLKWRKNWCQTRQ*YQTVLSLWQTVQAVN
Q*PRMTHFLLSPPRKKREQQLLNYIQLQIIEMA
QMEIRMSLIRGH*KTGQ*ACPHPPLLQSFSTGWG
IPVSQDLVESMRVPPLQQSQKL*ISRGTLTLPC
KVWVRPLWL*IQF*LKKENFWWFQKALQLRNKI
RIKR*PVPLLRKMLSLQELCRKSREHHLLDKILN
NFMKNQSQLTVPRTKHFS*VIHRVHPLPFLRQK
LNITRKWPHKSHC*LKVGLPRAWCHQEQVWPQS
QGRKPWGQSTTAPLCCHVCCQMGLMGPMLLTAVS
LLLWMLE*RTLNPREKLVPVR*VEM*RWMLQGL
MLYKVWLSPEERIYHTTPKTS*FQTSC*AKRRM
PF*VCQWLYRTKL*LTHRELEPQR*YLLIGRKGS
WREQTTAVPWVTLRKPK*TMKHILSYCSLLPRS
SPQTWSSQPMMMGPQLV*GKSCEPRLQAGKGAL
PLYLAWSLPRTHLCLRGQT**RRLPAV*WMLSSN
KSRPLEHCLLRGRPVTCHCPALSWVLSLKD*RV
LLQKK*VLSHLGRAYQWAVLLRKPRGALQDVLL
EGRSQRRSFYLSRGLSQQQKCQT*KLKMKWILEQ
VQFLKKWL*GA*LLH*R*SKAQ*PRR*TEKTGV
Q*SHALMQHLFWLPSRAQNVRTSWMLDWAESVP
QNKVYLKENLGVILTSFTHPVMTWTASSSQSQRK
SIWPVISPDPVHPPMTRLHWTDILLMAVMCLSP
RF*SQTGQEIGKALMDSTAMGWELRVEKVRVSL
LTQATWRRRRWTVSLKCLQTALS*GAPCALFLPS
GGTAGGLGKMQPAMQK*TTGV*AGAPLVCSTLL
A*VLTLITEVSV*KA*QEELVSETSHPHL*K*A
LQMPKSSDTHSVVRNGLTLWCHFQKRIWSQTREN
IGCLISRYVTDLSSRDLITVHQPFPLH*QNPSH
**QSAILDWTIHGPSTVPSTIPVLI*LRV*QKR
TIISCHIAPPRKILNGRVEQKSVVHSATSRIKCL
AARRAKKRKKKKIRLRRRRKILKTRRKIRRLST
GTLSVPFLLWVPSAVASV*SPSPTKMPILVQIA
VLLSTKAAEKV*PPVQRSK*SSPKGAFRHMTHHH
CPRSL*ETSPHSPRSVLGPQSSWWMKPLPPQYL
PIDDPSRVSRSPKVSPYRTLLELAMMRTCQTPG
NSCLIQQTH*IKSARSMSQQNHLLMRE*VQT*MK
DNYWETLRLSPNSWKQSLGVG**TASF*NSKRK
MWSNGKK*YMS*CRQSFIMSALSRS*VVCTARG
*WRICFLSSRW*KSCSPVWMS*SVSIANSSRGFW
SGRRSLWWIKVKRTFSSRG*GMCL*ISFQVRMQ
NV*RRHMASFVGNITSL*TTSKTFMPRISVFKP
L*RRR*AVQLLEGLEFQSAYCL*LSGLPSTQFYS
KEYCSVPKTMKWSRKI*HSP*AW*RM*LEL*TA
KWQVMKRKCVSMRFIQRQIASQS*G*RVVRCLP
RKI*NGRSLYVMGVCF*RMQQEG*KRFKQFFSLT
F*FSFKKKTRSTSLHHWTRSQQ*SL*RS*L*EK
WHMRRKVYS*SAWG*QIQRW*KSMPAPKRNETA
GFRSFRTQSTP*TEMKMKEFLVRMRKKRKCWTPE
PEN*KNNFTRRTKKSYSCWKRRR*FSGTWLSAA
PLSQRIAPQHIALEFSSAPTQKRLSKEDL**KV
Q*MRWRSFRVW*VEIWEAHLGRLSAAPLSKMWSV
PFPCPGEQRPLEDLTAIR*MLQKEARRKREMMA
KILGERNQIVA*KRVEMLTWYLCLKETVSRLSR
ALFISTSSSALCRVWCCSRTATLRTRNWC*ARGR
SLAACPARAPSLSRRSSAAWRSSARTWPTCRSS
RPSTSRRSAGASVSGKLVRGSCGSGRPSWPSAR
RRCSRGSRTWKRSGRSSSRRRAHTSMTWSDCVLP
RNSLRGNRSSCAGRQSGSASGRQNGTCVRFPIH
IPS**GSHRSSPVLRSPPRHLHLP*PNQGHWTQ
NFQCPQKGTASLGHTKIRGLFTY*VQPARQTKDQ
KGRARPLRPPLPLPACLG*QSQRKRRRKKRRTK
PAALSPVMVPRQKYQQRVKRSSADPLPLC*GSC
LLILASPPLLLSPRAQVSYTGRPLLLSVQSSWAA
PGPGQ*ATDDIECRVGKEAQTLLRP*FVTAQDS
QVGLALLRITLKVMAS*VQVMVLDTSGIPKG*K
SVSK*GLNLRMPFIWGNTKPNSRCFGLDLCTYMG
TCLHIHTGNARRRPSLHQASGQLSTRAVPGRTR
SPRISAVHPVLLRDWFPSKPIPGTYHPCFACIS
HFILGMTNICETSERRLDVYKRRDVHHLDLGVSG
TKATKQPIVSHSVIRSRRNILVFQHVYPHVLAM
DKVKRPTHHYPCSVTPFDCH*PLRRGHGLLAVF
LSPRRASPRQQLSGPCWVRAHHCQGSASHPGQAE
AVL*S*DSWLRSGFRRRVKPCVAVPASADLERS
WPGRRGCESALLMLGGLGKIGFLQKYM*RSVVE
LYSAPGSRYRWLPAARLCFCFSHRVFIFVHLRLS
PAGVCRTVHGNVAL*GPVHQKGGPGKFCASNVA
FNSCFFAPRKHGAFEHT*KKKNL*LGAY**IAS
WPCRWRYLSFSLFERGLV*NL*PTFVLFIVFVCL
CLFFFKGEPGLAQQSKLSSQYRVKWQPALFTLC
LLKCLEGPDEILKGGGPCPSLPHPASFFNQRMS
SPLFENEETRHL*PTFAFFCHGEYSPFRNRPKAK
TC*FFY*KYVPLQRP*TKS*VSFFHLFVQLQVT
AESVVTFLRSTRGLAVCSGHWLRVPLLGFAGGQ
Y*TCILLLVNVGRVPLFSGFGTIRGWC*WDLLAY
VLFTKTPWMLKLEHVATELDINVRGSLTPRPAV
MFHLLWLFWWSFLKIEISHLPRPHSKRFGQVLV
GQV*NQSSARNSLKPPNFIQEYSLQCSNRTAYQE
LCLHTFVISLPPLEVVLRGICSCPGDLPGMVAA
CAFAHGLDSALVAGSNGLSWFLSHEKGLFFWGD
SD*IPHTVSTPGHHVLHQAKEITCLKLCLSFGGK
MEFLSRAPRFPESSELPGRRLRLLSIPVISVVV
VR*HVHFKCSHRLASFSRQSNVLTVFSS*KMER
VKNMQTATFNLCQYSLYPRESYLGGRILTKVFLE
RYES*LFSPSVSQGNTIQSRPFAHFLPYLLPS*
GLSISREHKVLRPLALFLDVGGEVLVHARVELD
RPCLSRGWDYNLRGQNLIQKLLSTEVLSISSFLF
LGLFFCSQVFPRILVFALELRFTLMMVAQLCPE
DSQAGPGREFRKTVLVNGLQVVTKRVAVR*PQT
LQNDVHPLRFGCPWNVGA*K*PCGWNWGSGCWRS
VCLAFLQQDRLGAQPPMDASQPAPSLSSILRDK
EEGREFGLGFELSFQCSKAFLVNQSLGIYCLLA
RL*NEKCFNAAIKGRRGGGRENKGIFPSTHLI*L
SKD**AMNYFSISLRVKGVQPPTGCVPCHRSE*
PALQPGGTTCAAVRRGFCRKHSPPTPSPA*ASP
TFRHHLRA*AQAMGRAW*VCLWFRLSLWSPVCCC
PHGMRRGGVGIRRRVVGIHRIPLLSLLVCKCSM
DICVLNPIK*KRRVKTQMLYIHL*LCIK*SSFK
L*RFFSVCFLEFCHNILASYFIYLSF*LPASDPC
KVSLSPFKK**ISCEVL
Frame 1
ELKWGK*RSKSFHDVWLSAAAQVTTSTQRKGGFWRQGGEETVGGHFPEQPLPATLL*SLCRRAAAA
VNLSLP*QPECPVQEPYYWSHAARWAVLPCNPSS
QFLLRVYSREDSQALPPSRVPRPPSRASFGACA
DWSCVQGQRGARAAAVKRLCSAETAVPIARLGR
RRFSRLRGSGRLLSFSAAKVKSCPSSARGGAPGA
ARVLGHET*STASSLIW*LCCYSAAC*RGQS*R
*CSVLLGIFGFHPPSLYKYSEGQF*YIGDHCSW
S*LL*NSEGAALCFQRGPSRVCGG*RRLSFRPG*
SV*CSSIPSNQCWKSAGFELYPFS*PVRTPIWG
CEFP**EVGAGIQAPEAAHGVECIGDRSEFA*C
WPARDIDAFCCAAGTAEVDVVPVAEARWPRSSQY
PQPGRGDACELGLGARLSQAAPASNRGECWRTR
LLEQFIL*NTVWRLFCEASSRVGHLYINL*V*F
TS*TPISWRRLHWTNF*TYEHPTATNENKPQADG
QSYALNDDSTGSFQCPRDRWPVSSLCTGAHGPS
ATFFF*RD*EHSVLPREPCCTD*KSL*FVKHS*
GGEYRPFL*EEK*RRGKKRGRGGASTYCGLWNCI
*SRQLPSELA*LWSKGHGRPFVLWKQK*RNWNK
IFWNAHRPGVPEQWRCCASERLGHGARHSPVFL
WR*TGRHFNNKCQYPRHCRGNGTWAHEPRCHCLE
ECASGRGKYKGKI*EL*YWHSWSL*RARHK*AC
G*NQCSKLCPCCQFPGW*QTC*VFTCI***RNL
H*KNSRNGNFTKS*GEC*CSSRSEFCGDSSCCKR
QDFRWIRTLYSLSSRHR*GNVTLRFSPSWAGRR
CNATPELRNKFISCSKPKGQILTHLFYNWRR*T
LCRLCMSTEHSDF*WRFGCKTV**HS*RVRKHHS
KATQLTRSTRCLPL*RPTGSYSHL*PCKGYPGT
CGFLSFQSGG*QRPTKRCETR*TFNKYA*GGFT
STSSCP*NGERTGARPGSNIRQYFLSGKQSRQ*I
SNQG*RTFFCPLPERKGNSNS*TTYSYRL*RWP
RWKFE*A*YAATRRQGSRPVHILHCCRASARDG
EYQSHRTWWRA*GSRPSSNPRSSEYQGEH*LFPA
KCG*GHFGFRFSFD*RRKTSGGFRKLCSSGTR*
G*SGDLFLY*GKCSLFRNFAGRAENTTSWTRYS
TIS*KINLS*LCQGQSTSAK*FTGCILCLS*GRN
*T*QGSGPTSLTADSRWGCPEPGATRSKSGHRV
KAGSLGGRAQQLRSVAMSVARWV*WVRCS*LQS
AFSSGCWSEEHSIPGKN*CL*GEWRCDGGCYRG*
CSTRYG*AQKREYITQHPRHPDSKRLVEPREEC
RSRFASGSTGQSCD*PTGSWNPRDDTS*LGERE
AGGSRPQLYHG*R*GSPNRR*STSCPTAACCQGA
PHRHGALSP**WGPSWCEGSHASPAFRQGKEHS
LSTLHGLCPGRTSA*GGRLDRGGCQPYSGCCHR
TSQGRWSTAY*GGGLSHVTVQP*VGSSH*RTREC
FYRKSEYFPTWGEPTNGQYS*GSHGEPCRMFCW
KGGAREDHFTCPGA*ASSRNARRES*R*SGF*S
KFNF*RSGCREHSCYTEDEARPNDPGDKPRKLVY
NRAMP*CSISSGFQAEPRM*ELPGCWTGQRVYL
KTRCT*KRIWE*F*PLSLTQ**HGQHHLPKARG
RAFGL*YHRIQFIHR*HGFTGPTFFSWQ*CVSLP
DFKAKQVKRSAKP*WILQPWDGS*GSRK*E*AC
*PRRRGGGGDGQYH*SACKLLCPKELHALSFSL
PEAQLGAWEKCSQRCRNEPPEYELVPLWCAVLCW
PEC*L*LQKFQSRRLDRRSWCRKQAILISRSKL
CKCRRAQTPIQW*GTG*LFGVTFRRGSGVRPER
T*DV*SADMSQI*AAGI*LLYISHFLSIDKIHLI
NDNQPSWIGQFTALPQYLPQYQC*SD*EYNRRE
L*FPAT*PLQERF*MEEWNKSQSYIQLHQE*NV
*QQEEQRKGKRKR*D*GEGERF*RQGER*EDCQR
AHFQFHSCCGSHQL*PVYEALHQQRCLYLCKLQ
CFCPQRLPRKSSLLCKGQNEAAQREPSGT*HII
TAHGHYEKQALTAQGASSVRSPPGG*NRYHPNIC
Q*TIPAECLALQKCLHTEHYWSWQ**EHVKHLE
IPVSFNRLTK*NQQGQ*VNRITY**GSRYRHE*
RTTTGRL*D*VQTAGSRVLESDNRQQVSKTAKER
CGQTARSNI*VDADRVSSCPHSQDHEWCVQPGD
DGGSAF*AADGRKAVPLFG*ADQYP*PILPEDS
GAEEGVSGG*K*KELSHQEDRGCACKSVFR*ECR
TFKEDIWQVLWAT*PVCKLLQRPLCQG*AFSSL
CKEEDEQFSC*KAWNSRVHIACNSADYQVPSFI
PKNIAVYQRQ*SGAGRSSTVLEPGEGCDWSCRQQ
SGKL*KESASQ*DLYKDR*QVNHEDEEWSDVCQ
GRFETEEACT*WECVSEECSRKVERGSSSSSH*
HFSFPSRKRPEVHLCIIGPEVNSDLFKEADCERS
GT*GERFIPDQHGDDRSRDGRSPCQLQRGTKQL
DSDHSGHNQHPEQR*R*RNS**E*GRKENVGHQ
SPRIKRTTSPEGPKNPTLVGREGDDFPGHG*VQH
PSPRGLLPNT*P*SSLPLQHRRGSQRRTFNEKC
NK*GGDPSGFGEWKSGRHTWADCQQPH*ARCGR
SRFPAPESRDLWRI*QPSDECFKRRREGRGR*WP
RS*ENGIR*WPKKGWKC*PGIYA*KKQ*AGCPE
RCSSLRAPQRSAGCGAAAGQLH*GPETGAEREG
AHSQLVPPELPH*AGEAAQPGEAAPGPGQPAEAA
GPVPRGEAQARA*VGSS*EGAAGAGGPPGPARG
GGAAGAAGPGKGAGGAPAEEGHIPV*PGATACC
PETA*EGTGAAAPGGRAAQPAADRTGPVSGFPST
YQADEDPIVLPQS*GAPLAICTFHSQIRVIGLR
TFSVPKKEQHLSDTQR*GAFSHTEFNQPDKQRT
RRAEPGPCVHLCLYPPVWVNKAKGKEGEKKEEQN
QPLSAR*WSRVRSISRG*RDLLLTLFLSAEAAA
S*SWPAHLSCCPRVHKSLTLDAHCSSASSPPGR
PQVLDNKQQMILSVGWGRRPRLCFGHDL*LPRTL
RLGWPYSGLH*K*WPRKYR*WFWTRQEFLKAER
VYPSKV*TSECLLFGGTQNQTADVLDLICVRTW
GPVCIYTRGMPEEGPVCTRRLVNLAQGQCLDGPG
APAYQQFTQYSSETGFPLNPSRAHTTRVLHVFL
ISF*G*QTFVKPVREGLMCIKDVMCTTSISVFQ
ALKQQNNP*YLILSSDPEEISWFSSMFTHMFWPW
IK*RGLLTIIPAA*HLLIVTDHSEGATASWLCS
*APVVPLPDSSCLALAG*GHTTARGQPRTQARQ
KLCSEARTAG*EVGSGEG*SHV*QFLPVQIWRGA
GPEGVVVKAPFLC*EALAKLDFFKNTCKGLLLN
CTLPLEADTDGCLLLGFAFAFPTVFSSLFT*GF
PQLVCAGQFMVMLPSEAPYTRREALENFVLPTWP
SILAFLPLGSMGLLSTLKKRKICNLVLIDELQA
GLADGDIYLSVYLKEVWFKICSLHLFYLLYLCV
CVCFFLRVSQV*PNSLNYPVNTE*SGSQHCSLCV
F*SALKAQMKF*REGVHVLPSPTPPHSLIKGCL
LPCLRMKKLATSDLPLPFSVMENTHPSETDQRP
KPADFSIENMSPCKDPKQKVKFLSFTYLYNSKLQ
LNLS*LS*DLPGAWLSVLGTGSEFPSWDLQEGS
TEPAFFSL*M*AGCPCSPGLEQYEVGADGIYLR
TCSSQKHRGC*S*STSPQSLTSMLEGLLLPAQL*
CFICFGCFGGLF*K*RFHICPDPTQNDLVRFWL
DKFKIKVVPGIPSNHPTSSRNTVCSAATEPLTK
NCAYIPLSSLFPPWKLSSGGFVPVLGIYLGWWLP
VLLLMALTVL*LLDLMACLGFYHMRRGCFFGVT
RTEFPILFPRRDTMFSIKLKKSRA*NCA*VLGE
RWSSYPEPPDFQNRVSFLEGDCVFSQFQSSQSLS
LGDMCTLNALIGWLHFQDNQMY*LCFLLRKWRG
LKTCKLPLSTFASIPSTPVRAIWGEESLPRFFW
KGTNLNFFPLLCLRVILFRVAPLLIFSRICYLPE
ASVLVVSTKF*DLWRCFLMWEGRC*CMQGLN*I
DPALVEGGTITLEART*SRSCCPQKCFLFHHFC
F*GSFSVARSSQGF*YLHWS*GLL**WWPSCAQR
TARQALGGSLERQSW*MGFKWSQRGWL*GDPRH
CRTMCTLCVLDVLGMWEPRNNPVDGIGAAAAGD
LCALPSFSRTV*VRSHLWMRPSQPRRSRPSSETK
KRAGSLGLVLNFPFNVAKHS*LTRALESTACWP
GFKMKSVLMLP*KGGGGEEGKIKASFQVLI*FN
CQKIDRP*ITSPSH*GLKACNPPLAVSPATEVSD
LPYNQVGPPVLQSGGASAGSTHPPHLPRPELPL
PFVTT*GHEHRPWGVPGESACGSGLACGLLCAA
ARMGCAGEAWGSAGGWLGYTGYLCSHCLFANALW
TFVC*ILLNKKDGLKPRCCIFICNYV*SEAVLN
CKDFFQCVFSNFATTYWLRILFIFLSSYQLQTL
VKSPSALSKNNKFPVKFW
Frame 2
S*SGGNRGVNHFTMCG*VLQLR*PPVHRGRAVSGDRAERRPWVGISQSSLCQPPYFDHFAAEQQRR
STSASLSNLSAPSRSLTIGLMQRDGQFCRAIPA
RSSCSACTHGRTRRRYRLPACPAHPPERLSAHAR
TGAVCRASAEPEQPR*SACALPRLPCPLLASVA
AALAASGGAAAYCLSPRRR*RVVPARPAGEPRE
PHVSWVMKLNPQQAPLYGDCVVTVLLAEEDKAED
DVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPG
HDCCETVKVQLCASKEGLPVFVVAEEDFHFVQD
EAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGD
VNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDA
GPRETLMHFAVRLGLLRLTWFLLQKPGGRGALS
IHNQEGATPVSLALERGYHKLHQLLTEENAGEPD
SWSSLSYEIPYGDCSVRHHRELDIYTLTSESDS
HHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQM
DSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQ
RLSSSEETESTQCCPGSPVAQTESPCDLSSIVE
EENTDRSCRKKNKGVERKGEEVEPAPIVDSGTV
SDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTK
SSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSS
GGELGGISTTNVSTPDTAGEMEHGLMNPDATVW
KNVLQGGESTKERFENSNIGTAGASDVHVTSKPV
DKISVPNCAPAASSLDGNKPAESSLAFSNEETS
TEKTAETETSRSREESADAPVDQNSVVIPAAAK
DKISDGLEPYTLLAAGIGEAMSPSDLALLGLEED
VMPHQNSETNSSHAQSQKGKSSPICSTTGDDKL
CADSACQQNTVTSSGDLVAKLCDNIVSESESTT
ARQPSSQDPPDASHCEDPQAHTVTSDPVRDTQER
ADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSH
PHPVVPKMEKELVPDQAVISDSTFSLANSPGSE
SVTKDDALSFVPSQKEKGTATPELHTATDYRDGP
DGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMG
NTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSL
QSVGKATLALDSVLTEEGKLLVVSESSAAQEQDK
DKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQ
QFHEKSISADCAKDKALQLSNSPGASSAFLKAE
TEHNKEVAPQVSLLTQGGAAQSLVPPGASLATES
RQEALGAEHNSSALLPCLLPDGSDGSDALNCSQ
PSPLDVGVKNTQSQGKTSACEVSGDVTVDVTGV
NALQGMAEPRRENISHNTQDILIPNVLLSQEKNA
VLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGK
LEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKE
LPTDMELSAHDDGAPAGVREVMRAPPSGRERSTP
SLPCMVSAQDAPLPKGADLIEEAASRIVDAVIE
QVKAAGALLTEGEACHMSLSSPELGPLTKGLES
AFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAG
REEPEKIILPVQGPEPAAEMPDVKAEDEVDFRA
SSISEEVAVGSIAATLKMKQGPMTQAINRENWC
TIEPCPDAASLLASKQSPECENFLDVGLGRECTS
KQGVLKRESGSDSDLFHSPSDDMDSIIFPKPEE
EHLACDITGSSSSTDDTASLDRHSSHGSDVSLS
QILKPNRSRDRQSLDGFYSHGMGAEGRESESEPA
DPGDVEEEEMDSITEVPANCSVLRSSMRSLSPF
RRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSA
GLSADFNYRSFSLEGLTGGAGVGNKPSSSLEVSS
ANAEELRHPFSGEERVDSLVSLSEEDLESDQRE
HRMFDQQICHRSKQQGFNYCTSAISSPLTKSIS
LMTISHPGLDNSRPFHSTFHNTSANLTESITEEN
YNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMS
SSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVN
GHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCS
AFVHKGCRESLASCAKVKMKQPKGSLQAHDTSS
LPTVIMRNKPSQPKERPRSAVLLVDETATTPIF
ANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWK
FLSHSTDSLNKISKVNESTESLTDEGVGTDMNE
GQLLGDFEIESKQLEAESWSRIIDSKFLKQQKK
DVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGM
MADLLFEQQMVEKLFPCLDELISIHSQFFQRIL
ERKKESLVDKSEKNFLIKRIGDVLVNQFSGENA
ERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAF
VKKKMSSSVVRRLGIPECILLVTQRITKYPVLF
QRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDS
KVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAK
EDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTD
ILVFLQEKDQKYIFASLDQKSTVISLKKLIVRE
VAHEEKGLFLISMGMTDPEMVEVHASSKEERNSW
IQIIQDTINTLNRDEDEGIPSENEEEKKMLDTR
ARELKEQLHQKDQKILLLLEEKEMIFRDMAECS
TPLPEDCSPTHSPRVLFRSNTEEALKGGPLMKSA
INEVEILQGLVSGNLGGTLGPTVSSPIEQDVVG
PVSLPRRAETFGGFDSHQMNASKGGEKEEGDDG
QDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQS
VVHLYELLSALQGVVLQQDSYIEDQKLVLSERA
LTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQ
QAQYLEEKRRREREWEARERELREREALLAQREE
EVQQGQQDLEKEREELQQKKGTYQYDLERLRAA
QKQLEREQEQLRREAERLSQRQTERDLCQVSHP
HTKLMRIPSFFPSPEEPPSPSAPSIAKSGSLDSE
LSVSPKRNSISRTHKDKGPFHILSSTSQTNKGP
EGQSQAPASTSASTRLFGLTKPKEKKEKKKKNK
TSRSQPGDGPASEVSAEGEEIFC*PSSSLLRQLP
PDPGQPTSPAVPACTSLLHWTPTAPQRPVLLGG
PRSWTISNR*Y*VSGGEGGPDSASAMICDCPGL
SGWAGPTQDYTESNGLVSTGDGFGHVRNS*RLKE
CIQVRSEPPNAFYLGEHKTKQQMFWT*SVYVHG
DLSAYTHGECQKKAQSAPGVWST*HKGSAWTDP
EPPHISSSPSTPQRLVSL*THPGHIPPVFCMYFS
FHFRDDKHL*NQ*EKA*CV*KT*CAPPRSRCFR
H*SNKTTHSISFCHQIQKKYPGFPACLPTCFGH
G*SEEAYSPLSLQRDTF*LSLTTQKGPRPPGCVP
EPPSCLSQTAAVWPLLGEGTPLPGVSLAPRPGR
SCALKLGQLAEKWVQAKGEAMCSSSCQCRSGEE
LARKAWL*KRPSYVRRPWQNWISSKIHVKVCC*I
VLCPWKQIQMAACCSALLLLFPPCFHLCSLEAF
PSWCVQDSSW*CCPLRPRTPEGRPWKILCFQRG
LQFLLFCPSEAWGF*AHLKKEKSVTWCLLMNCKL
ALQMEIFIFQFI*KRSGLKFVAYICFIYCICVF
VFVFF*G*ARSSPTV*TIQSIPSEVAASTVHSV
SFEVP*RPR*NFKGRGSMSFPPPPRLIL*SKDVF
SLV*E*RNSPPLTYLCLFLSWRILTLQKQTKGQ
NLLIFLLKICPLAKTLNKKLSFFLSPICTTPSY
S*ICRDFPEIYPGLGCLFWALAPSSPPGICRRAV
LNLHSSPCKCRPGAPVLRVWNNTRLVLMGFTCV
RALHKNTVDAEVRARRHRA*HQC*RVSYSPPSC
DVSSALVVLVVFFKNRDFTSAQTPLKTIWSGSGW
TSLKSK*CPEFPQTTQLHPGIQSAVQQQNRLPR
TVLTYLCHLSSPLGSCPQGDLFLSWGFTWDGGC
LCFCSWP*QCSSCWI*WPVLVSIT*EGVVFLG*L
GLNSPYCFHAGTPCSPSS*RNHVPETVLKFWGK
DGVPIQSPQISRIE*ASWKETASSLNSSHLSRC
R*VTCAL*MLSSVGFIFKTIKCIDCVFFLENGEG
*KHANCHFQPLPVFPLPP*ELSGGKNPYQGFFG
KVRILTFFPFCVSG*YYSESPLCSFSPVFVTFL
RPQY*S*AQSFETFGVVS*CGRGGVSACKG*TR*
TLP**RVGL*P*RPELDPEVAVHRSAFYFIIFV
SRALFL*PGLPKDFSICIGVEVYSNDGGPAVPR
GQPGRPWEGV*KDSPGEWASSGHKEGGCEVTPDT
AERCAPSAFWMSLECGSLEITLWMELGQRLLEI
CVPCLPSAGPSRCAATYGCVPASPVALVHPQRQ
RRGQGVWAWF*TFLSM*QSIPS*PEPWNLLPAGQ
ALK*KVF*CCHKREAGGRKGK*RHLSKYSSNLI
VKRLIGHELLLHLTKG*RRATPHWLCPLPPK*V
TCPTTRWDHLCCSPEGLLQEALTPHTFPGLSFPY
LSSPPEGMSTGHGACLVSLPVVQA*PVVSCVLL
PAWDAQGRRGDPQEGGWDTPDTSALIACLQMLY
GHLCAKSY*IKKTG*NPDAVYSFVIMYKVKQF*T
VKIFFSVFSRILPQHTGFVFYLSFFLVTSFRPL
*SLPQPFQKIINFL*SS
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