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Sequences

Sequence AKAP13.cAug05

GCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTTTGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGA TTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACCACAGCAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAA GACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGGGATACCCAGGAACGTGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAA AAGATGTGAAACTAGATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACATCCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCA GGCAGTAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAATCAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAA AAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCCAGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGGG CAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGGAATACCAGTCTCACAGGACTTGGTGGAGAGCATGAGGGTCCCGCCCC TCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGCAAAGTGTGGGTAAGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAA GAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAAGGATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTT CAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAACAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGC ACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCAGAAACTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAA GGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGTCTGGCCACAGAGTCAAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGC CATGTCTGTTGCCAGATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAGCCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAA AACTAGTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTAATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACAC AACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGCCGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGACC CACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAGCTGGAGGGAGCAGACCACAGCTGTACCATGGGTGACGCTGAGGAAGC CCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGCTCCCCACAGACATGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCT GGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCCCTCTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGG GGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAACAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCA CATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAGAGTGCTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCA ATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCAGGATGTTTTGCTGGAAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGC CAGCAGCAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACT GAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTACAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCAAGCAG AGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTCAAAACAAGGTGTACTTAAAAGAGAATCTGGGAGTGATTCTGACCTCT TTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAAGAGCATTTGGCCTGTGATATCACCGGATCCAGTTCATCCACCGATGA CACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCCAGATTTTAAAGCCAAACAGGTCAAGAGATCGGCAAAGCCTTGATGGA TTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGCTGACCCAGGCGACGTGGAGGAGGAGGAGATGGACAGTATCACTGAAG TGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTCCGGAGGCACAGCTGGGGGCCTGGGAAAAATGCAGCCAGCGATGCAGA AATGAACCACCGGAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGGTGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTCTGCAAATGCCGAA GAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTGTCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAACATAGGATGTTTG ATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTACATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCATTAATGACAATCAG CCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAATACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAACTATAATTTCCTG CCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAAGTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCTAGCAGCAAGAAGA GCAAAGAAAAGGAAAAAGAAAAAGATAAGATTAAGGAGAAGGAGAAAGATTCTAAAGACAAGGAGAAAGATAAGAAGACTGTCAACGGGCACACTTTCAG TTCCATTCCTGTTGTGGGTCCCATCAGCTGTAGCCAGTGTATGAAGCCCTTCACCAACAAAGATGCCTATACTTGTGCAAATTGCAGTGCTTTTGTCCAC AAAGGCTGCCGAGAAAGTCTAGCCTCCTGTGCAAAGGTCAAAATGAAGCAGCCCAAAGGGAGCCTTCAGGCACATGACACATCATCACTGCCCACGGTCA TTATGAGAAACAAGCCCTCACAGCCCAAGGAGCGTCCTCGGTCCGCAGTCCTCCTGGTGGATGAAACCGCTACCACCCCAATATTTGCCAATAGACGATC CCAGCAGAGTGTCTCGCTCTCCAAAAGTGTCTCCATACAGAACATTACTGGAGTTGGCAATGATGAGAACATGTCAAACACCTGGAAATTCCTGTCTCAT TCAACAGACTCACTAAATAAAATCAGCAAGGTCAATGAGTCAACAGAATCACTTACTGATGAGGGTACAGACATGAATGAAGGACAACTACTGGGAGACT TTGAGATTGAGTCCAAACAGCTGGAAGCAGAGTCTTGGAGTCGGATAATAGACAGCAAGTTTCTAAAACAGCAAAAGAAAGATGTGGTCAAACGGCAAGA AGTAATATATGAGTTGATGCAGACAGAGTTTCATCATGTCCGCACTCTCAAGATCATGAGTGGTGTGTACAGCCAGGGGATGATGGCGGATCTGCTTTTT GAGCAGCAGATGGTAGAAAAGCTGTTCCCCTGTTTGGATGAGCTGATCAGTATCCATAGCCAATTCTTCCAGAGGATTCTGGAGCGGAAGAAGGAGTCTC TGGTGGATAAAAGTGAAAAGAACTTTCTCATCAAGAGGATAGGGGATGTGCTTGTAAATCAGTTTTCAGGTGAGAATGCAGAACGTTTAAAGAAGACATA TGGCAAGTTTTGTGGGCAACATAACCAGTCTGTAAACTACTTCAAAGACCTTTATGCCAAGGATAAGCGTTTTCAAGCCTTTGTAAAGAAGAAGATGAGC AGTTCAGTTGTTAGAAGGCTTGGAATTCCAGAGTGCATATTGCTTGTAACTCAGCGGATTACCAAGTACCCAGTTTTATTCCAAAGAATATTGCAGTGTA CCAAAGACAATGAAGTGGAGCAGGAAGATCTAGCACAGTCCTTGAGCCTGGTGAAGGATGTGATTGGAGCTGTAGACAGCAAAGTGGCAAGTTATGAAAA GAAAGTGCGTCTCAATGAGATTTATACAAAGACAGATAGCAAGTCAATCATGAGGATGAAGAGTGGTCAGATGTTTGCCAAGGAAGATTTGAAACGGAAG AAGCTTGTACGTGATGGGAGTGTGTTTCTGAAGAATGCAGCAGGAAGGTTGAAAGAGGTTCAAGCAGTTCTTCTCACTGACATTTTAGTTTTCCTTCAAG AAAAAGACCAGAAGTACATCTTTGCATCATTGGACCAGAAGTCAACAGTGATCTCTTTAAAGAAGCTGATTGTGAGAGAAGTGGCACATGAGGAGAAAGG TTTATTCCTGATCAGCATGGGGATGACAGATCCAGAGATGGTAGAAGTCCATGCCAGCTCCAAAGAGGAACGAAACAGCTGGATTCAGATCATTCAGGAC ACAATCAACACCCTGAACAGAGATGAAGATGAAGGAATTCCTAGTGAGAATGAGGAAGAAAAGAAAATGTTGGACACCAGAGCCCGAGAATTAAAAGAAC AACTTCACCAGAAGGACCAAAAAATCCTACTCTTGTTGGAAGAGAAGGAGATGATTTTCCGGGACATGGCTGAGTGCAGCACCCCTCTCCCAGAGGATTG CTCCCCAACACATAGCCCTAGAGTTCTCTTCCGCTCCAACACAGAAGAGGCTCTCAAAGGAGGACCTTTAATGAAAAGTGCAATAAATGAGGTGGAGATC CTTCAGGGTTTGGTGAGTGGAAATCTGGGAGGCACACTTGGGCCGACTGTCAGCAGCCCCATTGAGCAAGATGTGGTCGGTCCCGTTTCCCTGCCCCGGA GAGCAGAGACCTTTGGAGGATTTGACAGCCATCAGATGAATGCTTCAAAAGGAGGCGAGAAGGAAGAGGGAGATGATGGCCAAGATCTTAGGAGAACGGA ATCAGATAGTGGCCTAAAAAAGGGTGGAAATGCTAACCTGGTATTTATGCTTAAAAGAAACAGTGAGCAGGTTGTCCAGAGCGTTGTTCATCTCTACGAG CTCCTCAGCGCTCTGCAGGGTGTGGTGCTGCAGCAGGACAGCTACATTGAGGACCAGAAACTGGTGCTGAGCGAGAGGGCGCTCACTCGCAGCTTGTCCC GCCCGAGCTCCCTCATTGAGCAGGAGAAGCAGCGCAGCCTGGAGAAGCAGCGCCAGGACCTGGCCAACCTGCAGAAGCAGCAGGCCCAGTACCTCGAGGA GAAGCGCAGGCGCGAGCGTGAGTGGGAAGCTCGTGAGAGGGAGCTGCGGGAGCGGGAGGCCCTCCTGGCCCAGCGCGAGGAGGAGGTGCAGCAGGGGCAG CAGGACCTGGAAAAGGAGCGGGAGGAGCTCCAGCAGAAGAAGGGCACATACCAGTATGACCTGGAGCGACTGCGTGCTGCCCAGAAACAGCTTGAGAGGG AACAGGAGCAGCTGCGCCGGGAGGCAGAGCGGCTCAGCCAGCGGCAGACAGAACGGGACCTGTGTCAGGTTTCCCATCCACATACCAAGCTGATGAGGAT CCCATCGTTCTTCCCCAGTCCTGAGGAGCCCCCCTCGCCATCTGCACCTTCCATAGCCAAATCAGGGTCATTGGACTCAGAACTTTCAGTGTCCCCAAAA AGGAACAGCATCTCTCGGACACACAAAGATAAGGGGCCTTTTCACATACTGAGTTCAACCAGCCAGACAAACAAAGGACCAGAAGGGCAGAGCCAGGCCC CTGCGTCCACCTCTGCCTCTACCCGCCTGTTTGGGTTAACAAAGCCAAAGGAAAAGAAGGAGAAAAAAAAGAAGAACAAAACCAGCCGCTCTCAGCCCGG TGATGGTCCCGCGTCAGAAGTATCAGCAGAGGGTGAAGAGATCTTCTGCTGACCCTCTTCCTCTCTGCTGAGGCAGCTGCCTCCTGATCCTGGCCAGCCC ACCTCTCCTGCTGTCCCCGCGTGCACAAGTCTCTTACACTGGACGCCCACTGCTCCTCAGCGTCCAGTCCTCCTGGGCGGCCCCAGGTCCTGGACAATAA GCAACAGATGATATTGAGTGTCGGGTGGGGAAGGAGGCCCAGACTCTGCTTCGGCCATGATTTGTGACTGCCCAGGACTCTCAGGTTGGGCTGGCCCTAC TCAGGATTACACTGAAAGTAATGGCCTCGTAAGTACAGGTGATGGTTTTGGACACGTCAGGAATTCCTAAAGGCTGAAAGAGTGTATCCAAGTAAGGTCT GAACCTCCGAATGCCTTTTATTTGGGGGAACACAAAACCAAACAGCAGATGTTTTGGACTTGATCTGTGTACGTACATGGGGACCTGTCTGCATATACAC ACGGGGAATGCCAGAAGAAGGCCCAGTCTGCACCAGGCGTCTGGTCAACTTAGCACAAGGGCAGTGCCTGGACGGACCCGGAGCCCCCGCATATCAGCAG TTCACCCAGTACTCCTCAGAGACTGGTTTCCCTCTAAACCCATCCCGGGCACATACCACCCGTGTTTTGCATGTATTTCTCATTTCATTTTAGGGATGAC AAACATTTGTGAAACCAGTGAGAGAAGGCTTGATGTGTATAAAAGACGTGATGTGCACCACCTCGATCTCGGTGTTTCAGGCACTAAAGCAACAAAACAA CCCATAGTATCTCATTCTGTCATCAGATCCAGAAGAAATATCCTGGTTTTCCAGCATGTTTACCCACATGTTTTGGCCATGGATAAAGTGAAGAGGCCTA CTCACCATTATCCCTGCAGCGTGACACCTTTTGATTGTCACTGACCACTCAGAAGGGGCCACGGCCTCCTGGCTGTGTTCCTGAGCCCCCGTCGTGCCTC TCCCAGACAGCAGCTGTCTGGCCCTTGCTGGGTGAGGGCACACCACTGCCAGGGGTCAGCCTCGCACCCAGGCCAGGCAGAAGCTGTGCTCTGAAGCTAG GACAGCTGGCTGAGAAGTGGGTTCAGGCGAAGGGTGAAGCCATGTGTAGCAGTTCCTGCCAGTGCAGATCTGGAGAGGAGCTGGCCCGGAAGGCGTGGTT GTGAAAGCGCCCTTCTTATGTTAGGAGGCCTTGGCAAAATTGGATTTCTTCAAAAATACATGTAAAGGTCTGTTGTTGAATTGTACTCTGCCCCTGGAAG CAGATACAGATGGCTGCCTGCTGCTCGGCTTTGCTTTTGCTTTTCCCACCGTGTTTTCATCTTTGTTCACTTGAGGCTTTCCCCAGCTGGTGTGTGCAGG ACAGTTCATGGTAATGTTGCCCTCTGAGGCCCCGTACACCAGAAGGGAGGCCCTGGAAAATTTTGTGCTTCCAACGTGGCCTTCAATTCTTGCTTTTTTG CCCCTCGGAAGCATGGGGCTTTTGAGCACACTTAAAAAAAGAAAAATCTGTAACTTGGTGCTTATTGATGAATTGCAAGCTGGCCTTGCAGATGGAGATA TTTATCTTTCAGTTTATTTGAAAGAGGTCTGGTTTAAAATTTGTAGCCTACATTTGTTTTATTTATTGTATTTGTGTGTTTGTGTTTGTTTTTTTTTAAG GGTGAGCCAGGTCTAGCCCAACAGTCTAAACTATCCAGTCAATACCGAGTGAAGTGGCAGCCAGCACTGTTCACTCTGTGTCTTTTGAAGTGCCTTGAAG GCCCAGATGAAATTTTAAAGGGAGGGGGTCCATGTCCTTCCCTCCCCCACCCCGCCTCATTCTTTAATCAAAGGATGTCTTCTCCCTTGTTTGAGAATGA AGAAACTCGCCACCTCTGACCTACCTTTGCCTTTTTCTGTCATGGAGAATACTCACCCTTCAGAAACAGACCAAAGGCCAAAACCTGCTGATTTTTCTAT TGAAAATATGTCCCCTTGCAAAGACCCTAAACAAAAAGTTAAGTTTCTTTCTTTCACCTATTTGTACAACTCCAAGTTACAGCTGAATCTGTCGTGACTT TCCTGAGATCTACCCGGGGCTTGGCTGTCTGTTCTGGGCACTGGCTCCGAGTTCCCCTCCTGGGATTTGCAGGAGGGCAGTACTGAACCTGCATTCTTCT CCTTGTAAATGTAGGCCGGGTGCCCCTGTTCTCCGGGTTTGGAACAATACGAGGTTGGTGCTGATGGGATTTACTTGCGTACGTGCTCTTCACAAAAACA CCGTGGATGCTGAAGTTAGAGCACGTCGCCACAGAGCTTGACATCAATGTTAGAGGGTCTCTTACTCCCCGCCCAGCTGTGATGTTTCATCTGCTTTGGT TGTTTTGGTGGTCTTTTTTAAAAATAGAGATTTCACATCTGCCCAGACCCCACTCAAAACGATTTGGTCAGGTTCTGGTTGGACAAGTTTAAAATCAAAG TAGTGCCCGGAATTCCCTCAAACCACCCAACTTCATCCAGGAATACAGTCTGCAGTGCAGCAACAGAACCGCTTACCAAGAACTGTGCTTACATACCTTT GTCATCTCTCTTCCCCCCTTGGAAGTTGTCCTCAGGGGGATTTGTTCCTGTCCTGGGGATTTACCTGGGATGGTGGCTGCCTGTGCTTTTGCTCATGGCC TTGACAGTGCTCTAGTTGCTGGATCTAATGGCCTGTCTTGGTTTCTATCACATGAGAAGGGGTTGTTTTTTTGGGGTGACTCGGACTGAATTCCCCATAC TGTTTCCACGCCGGGACACCATGTTCTCCATCAAGCTAAAGAAATCACGTGCCTGAAACTGTGCTTAAGTTTTGGGGGAAAGATGGAGTTCCTATCCAGA GCCCCCAGATTTCCAGAATCGAGTGAGCTTCCTGGAAGGAGACTGCGTCTTCTCTCAATTCCAGTCATCTCAGTCGTTGTCGTTAGGTGACATGTGCACT TTAAATGCTCTCATCGGTTGGCTTCATTTTCAAGACAATCAAATGTATTGACTGTGTTTTCTTCTTAGAAAATGGAGAGGGTTAAAAACATGCAAACTGC CACTTTCAACCTTTGCCAGTATTCCCTCTACCCCCGTGAGAGCTATCTGGGGGGAAGAATCCTTACCAAGGTTTTTTTGGAAAGGTACGAATCTTAACTT TTTTCCCCTTCTGTGTCTCAGGGTAATACTATTCAGAGTCGCCCCTTTGCTCATTTTCTCCCGTATTTGTTACCTTCCTGAGGCCTCAGTATTAGTCGTG AGCACAAAGTTTTGAGACCTTTGGCGTTGTTTCTTGATGTGGGAGGGGAGGTGTTAGTGCATGCAAGGGTTGAACTAGATAGACCCTGCCTTAGTAGAGG GTGGGACTATAACCTTAGAGGCCAGAACTTGATCCAGAAGTTGCTGTCCACAGAAGTGCTTTCTATTTCATCATTTTTGTTTCTAGGGCTCTTTTTCTGT AGCCAGGTCTTCCCAAGGATTTTAGTATTTGCATTGGAGTTGAGGTTTACTCTAATGATGGTGGCCCAGCTGTGCCCAGAGGACAGCCAGGCAGGCCCTG GGAGGGAGTTTAGAAAGACAGTCCTGGTGAATGGGCTTCAAGTGGTCACAAAGAGGGTGGCTGTGAGGTGACCCCAGACACTGCAGAACGATGTGCACCC TCTGCGTTTTGGATGTCCTTGGAATGTGGGAGCCTAGAAATAACCCTGTGGATGGAATTGGGGCAGCGGCTGCTGGAGATCTGTGTGCCTTGCCTTCCTT CAGCAGGACCGTCTAGGTGCGCAGCCACCTATGGATGCGTCCCAGCCAGCCCCGTCGCTCTCGTCCATCCTCAGAGACAAAGAAGAGGGCAGGGAGTTTG GGCTTGGTTTTGAACTTTCCTTTCAATGTAGCAAAGCATTCCTAGTTAACCAGAGCCTTGGAATCTACTGCCTGCTGGCCAGGCTTTAAAATGAAAAGTG TTTTAATGCTGCCATAAAAGGGAGGCGGGGGGGAGGAAGGGAAAATAAAGGCATCTTTCCAAGTACTCATCTAATTTAATTGTCAAAAGATTGATAGGCC ATGAATTACTTCTCCATCTCACTAAGGGTTAAAGGCGTGCAACCCCCCACTGGCTGTGTCCCCTGCCACCGAAGTGAGTGACCTGCCCTACAACCAGGTG GGACCACCTGTGCTGCAGTCCGGAGGGGCTTCTGCAGGAAGCACTCACCCCCCACACCTTCCCCGGCCTGAGCTTCCCCTACCTTTCGTCACCACCTGAG GGCATGAGCACAGGCCATGGGGCGTGCCTGGTGAGTCTGCCTGTGGTTCAGGCTTAGCCTGTGGTCTCCTGTGTGCTGCTGCCCGCATGGGATGCGCAGG GGAGGCGTGGGGATCCGCAGGAGGGTGGTTGGGATACACCGGATACCTCTGCTCTCATTGCTTGTTTGCAAATGCTCTATGGACATTTGTGTGCTAAATC CTATTAAATAAAAAAGACGGGTTAAAACCCAGATGCTGTATATTCATTTGTAATTATGTATAAAGTGAAGCAGTTTTAAACTGTAAAGATTTTTTTCAGT GTGTTTTCTCGAATTTTGCCACAACATACTGGCTTCGTATTTTATTTATCTTTCTTTCTAGTTACCAGCTTCAGACCCTTGTAAAGTCTCCCTCAGCCCT TTCAAAAAATAATAAATTTCCTGTGAAGTTCTGG

AKAP13-F1 (forward primer)
AKAP13-R1 (reverse primer)
Single exon skipping

Frame 0

AKRANPHPFVLQLETINFVQTLHVNRTQ*LLVA IWLQNCVIT*LASPKAPQQGNPAHKIHPMPPTVK THRLIQSPLTL*GIPRNVRIFVLSKWWITKANE KM*N*INL*QICLRWFHIHIQLSLKWRKNWCQT RQ*YQTVLSLWQTVQAVNQ*PRMTHFLLSPPRKK REQQLLNYIQLQIIEMAQMEIRMSLIRGH*KTG Q*ACPHPPLLQSFSTGWGIPVSQDLVESMRVPP LQQSQKL*ISRGTLTLPCKVWVRPLWL*IQF*LK KENFWWFQKALQLRNKIRIKR*PVPLLRKMLSL QELCRKSREHHLLDKILNNFMKNQSQLTVPRTK HFS*VIHRVHPLPFLRQKLNITRKWPHKSHC*LK VGLPRAWCHQEQVWPQSQGRKPWGQSTTAPLCC HVCCQMGLMGPMLLTAVSLLLWMLE*RTLNPRE KLVPVR*VEM*RWMLQGLMLYKVWLSPEERIYHT TPKTS*FQTSC*AKRRMPF*VCQWLYRTKL*LT HRELEPQR*YLLIGRKGSWREQTTAVPWVTLRK PK*TMKHILSYCSLLPRSSPQTWSSQPMMMGPQL V*GKSCEPRLQAGKGALPLYLAWSLPRTHLCLR GQT**RRLPAV*WMLSSNKSRPLEHCLLRGRPV TCHCPALSWVLSLKD*RVLLQKK*VLSHLGRAYQ WAVLLRKPRGALQDVLLEGRSQRRSFYLSRGLS QQQKCQT*KLKMKWILEQVQFLKKWL*GA*LLH *R*SKAQ*PRR*TEKTGVQ*SHALMQHLFWLPSR AQNVRTSWMLDWAESVPQNKVYLKENLGVILTS FTHPVMTWTASSSQSQRKSIWPVISPDPVHPPM TRLHWTDILLMAVMCLSPRF*SQTGQEIGKALMD STAMGWELRVEKVRVSLLTQATWRRRRWTVSLK CLQTALS*GAPCALFLPSGGTAGGLGKMQPAMQ K*TTGVSV*KA*QEELVSETSHPHL*K*ALQMPK SSDTHSVVRNGLTLWCHFQKRIWSQTRENIGCL ISRYVTDLSSRDLITVHQPFPLH*QNPSH**QS AILDWTIHGPSTVPSTIPVLI*LRV*QKRTIISC HIAPPRKILNGRVEQKSVVHSATSRIKCLAARR AKKRKKKKIRLRRRRKILKTRRKIRRLSTGTLS VPFLLWVPSAVASV*SPSPTKMPILVQIAVLLST KAAEKV*PPVQRSK*SSPKGAFRHMTHHHCPRS L*ETSPHSPRSVLGPQSSWWMKPLPPQYLPIDD PSRVSRSPKVSPYRTLLELAMMRTCQTPGNSCLI QQTH*IKSARSMSQQNHLLMRVQT*MKDNYWET LRLSPNSWKQSLGVG**TASF*NSKRKMWSNGK K*YMS*CRQSFIMSALSRS*VVCTARG*WRICFL SSRW*KSCSPVWMS*SVSIANSSRGFWSGRRSL WWIKVKRTFSSRG*GMCL*ISFQVRMQNV*RRH MASFVGNITSL*TTSKTFMPRISVFKPL*RRR*A VQLLEGLEFQSAYCL*LSGLPSTQFYSKEYCSV PKTMKWSRKI*HSP*AW*RM*LEL*TAKWQVMK RKCVSMRFIQRQIASQS*G*RVVRCLPRKI*NGR SLYVMGVCF*RMQQEG*KRFKQFFSLTF*FSFK KKTRSTSLHHWTRSQQ*SL*RS*L*EKWHMRRK VYS*SAWG*QIQRW*KSMPAPKRNETAGFRSFRT QSTP*TEMKMKEFLVRMRKKRKCWTPEPEN*KN NFTRRTKKSYSCWKRRR*FSGTWLSAAPLSQRI APQHIALEFSSAPTQKRLSKEDL**KVQ*MRWRS FRVW*VEIWEAHLGRLSAAPLSKMWSVPFPCPG EQRPLEDLTAIR*MLQKEARRKREMMAKILGER NQIVA*KRVEMLTWYLCLKETVSRLSRALFISTS SSALCRVWCCSRTATLRTRNWC*ARGRSLAACP ARAPSLSRRSSAAWRSSARTWPTCRSSRPSTSR RSAGASVSGKLVRGSCGSGRPSWPSARRRCSRGS RTWKRSGRSSSRRRAHTSMTWSDCVLPRNSLRG NRSSCAGRQSGSASGRQNGTCVRFPIHIPS**G SHRSSPVLRSPPRHLHLP*PNQGHWTQNFQCPQK GTASLGHTKIRGLFTY*VQPARQTKDQKGRARP LRPPLPLPACLG*QSQRKRRRKKRRTKPAALSP VMVPRQKYQQRVKRSSADPLPLC*GSCLLILASP PLLLSPRAQVSYTGRPLLLSVQSSWAAPGPGQ* ATDDIECRVGKEAQTLLRP*FVTAQDSQVGLAL LRITLKVMAS*VQVMVLDTSGIPKG*KSVSK*GL NLRMPFIWGNTKPNSRCFGLDLCTYMGTCLHIH TGNARRRPSLHQASGQLSTRAVPGRTRSPRISA VHPVLLRDWFPSKPIPGTYHPCFACISHFILGMT NICETSERRLDVYKRRDVHHLDLGVSGTKATKQ PIVSHSVIRSRRNILVFQHVYPHVLAMDKVKRP THHYPCSVTPFDCH*PLRRGHGLLAVFLSPRRAS PRQQLSGPCWVRAHHCQGSASHPGQAEAVL*S* DSWLRSGFRRRVKPCVAVPASADLERSWPGRRG CESALLMLGGLGKIGFLQKYM*RSVVELYSAPGS RYRWLPAARLCFCFSHRVFIFVHLRLSPAGVCR TVHGNVAL*GPVHQKGGPGKFCASNVAFNSCFF APRKHGAFEHT*KKKNL*LGAY**IASWPCRWRY LSFSLFERGLV*NL*PTFVLFIVFVCLCLFFFK GEPGLAQQSKLSSQYRVKWQPALFTLCLLKCLE GPDEILKGGGPCPSLPHPASFFNQRMSSPLFENE ETRHL*PTFAFFCHGEYSPFRNRPKAKTC*FFY *KYVPLQRP*TKS*VSFFHLFVQLQVTAESVVT FLRSTRGLAVCSGHWLRVPLLGFAGGQY*TCILL LVNVGRVPLFSGFGTIRGWC*WDLLAYVLFTKT PWMLKLEHVATELDINVRGSLTPRPAVMFHLLW LFWWSFLKIEISHLPRPHSKRFGQVLVGQV*NQS SARNSLKPPNFIQEYSLQCSNRTAYQELCLHTF VISLPPLEVVLRGICSCPGDLPGMVAACAFAHG LDSALVAGSNGLSWFLSHEKGLFFWGDSD*IPHT VSTPGHHVLHQAKEITCLKLCLSFGGKMEFLSR APRFPESSELPGRRLRLLSIPVISVVVVR*HVH FKCSHRLASFSRQSNVLTVFSS*KMERVKNMQTA TFNLCQYSLYPRESYLGGRILTKVFLERYES*L FSPSVSQGNTIQSRPFAHFLPYLLPS*GLSISR EHKVLRPLALFLDVGGEVLVHARVELDRPCLSRG WDYNLRGQNLIQKLLSTEVLSISSFLFLGLFFC SQVFPRILVFALELRFTLMMVAQLCPEDSQAGP GREFRKTVLVNGLQVVTKRVAVR*PQTLQNDVHP LRFGCPWNVGA*K*PCGWNWGSGCWRSVCLAFL QQDRLGAQPPMDASQPAPSLSSILRDKEEGREF GLGFELSFQCSKAFLVNQSLGIYCLLARL*NEKC FNAAIKGRRGGGRENKGIFPSTHLI*LSKD**A MNYFSISLRVKGVQPPTGCVPCHRSE*PALQPG GTTCAAVRRGFCRKHSPPTPSPA*ASPTFRHHLR A*AQAMGRAW*VCLWFRLSLWSPVCCCPHGMRR GGVGIRRRVVGIHRIPLLSLLVCKCSMDICVLN PIK*KRRVKTQMLYIHL*LCIK*SSFKL*RFFSV CFLEFCHNILASYFIYLSF*LPASDPCKVSLSP FKK**ISCEVL

Frame 1

PKGQILTHLFYNWRR*TLCRLCMSTEHSDF*WR FGCKTV**HS*RVRKHHSKATQLTRSTRCLPL* RPTGSYSHL*PCKGYPGTCGFLSFQSGG*QRPTK RCETR*TFNKYA*GGFTSTSSCP*NGERTGARP GSNIRQYFLSGKQSRQ*ISNQG*RTFFCPLPER KGNSNS*TTYSYRL*RWPRWKFE*A*YAATRRQG SRPVHILHCCRASARDGEYQSHRTWWRA*GSRP SSNPRSSEYQGEH*LFPAKCG*GHFGFRFSFD* RRKTSGGFRKLCSSGTR*G*SGDLFLY*GKCSLF RNFAGRAENTTSWTRYSTIS*KINLS*LCQGQS TSAK*FTGCILCLS*GRN*T*QGSGPTSLTADS RWGCPEPGATRSKSGHRVKAGSLGGRAQQLRSVA MSVARWV*WVRCS*LQSAFSSGCWSEEHSIPGK N*CL*GEWRCDGGCYRG*CSTRYG*AQKREYIT QHPRHPDSKRLVEPREECRSRFASGSTGQSCD*P TGSWNPRDDTS*LGEREAGGSRPQLYHG*R*GS PNRR*STSCPTAACCQGAPHRHGALSP**WGPS WCEGSHASPAFRQGKEHSLSTLHGLCPGRTSA*G GRLDRGGCQPYSGCCHRTSQGRWSTAY*GGGLS HVTVQP*VGSSH*RTRECFYRKSEYFPTWGEPT NGQYS*GSHGEPCRMFCWKGGAREDHFTCPGA*A SSRNARRES*R*SGF*SKFNF*RSGCREHSCYT EDEARPNDPGDKPRKLVYNRAMP*CSISSGFQA EPRM*ELPGCWTGQRVYLKTRCT*KRIWE*F*PL SLTQ**HGQHHLPKARGRAFGL*YHRIQFIHR* HGFTGPTFFSWQ*CVSLPDFKAKQVKRSAKP*W ILQPWDGS*GSRK*E*AC*PRRRGGGGDGQYH*S ACKLLCPKELHALSFSLPEAQLGAWEKCSQRCR NEPPEFQSRRLDRRSWCRKQAILISRSKLCKCR RAQTPIQW*GTG*LFGVTFRRGSGVRPERT*DV* SADMSQI*AAGI*LLYISHFLSIDKIHLINDNQ PSWIGQFTALPQYLPQYQC*SD*EYNRREL*FP AT*PLQERF*MEEWNKSQSYIQLHQE*NV*QQEE QRKGKRKR*D*GEGERF*RQGER*EDCQRAHFQ FHSCCGSHQL*PVYEALHQQRCLYLCKLQCFCP QRLPRKSSLLCKGQNEAAQREPSGT*HIITAHGH YEKQALTAQGASSVRSPPGG*NRYHPNICQ*TI PAECLALQKCLHTEHYWSWQ**EHVKHLEIPVS FNRLTK*NQQGQ*VNRITY**GYRHE*RTTTGRL *D*VQTAGSRVLESDNRQQVSKTAKERCGQTAR SNI*VDADRVSSCPHSQDHEWCVQPGDDGGSAF *AADGRKAVPLFG*ADQYP*PILPEDSGAEEGVS GG*K*KELSHQEDRGCACKSVFR*ECRTFKEDI WQVLWAT*PVCKLLQRPLCQG*AFSSLCKEEDE QFSC*KAWNSRVHIACNSADYQVPSFIPKNIAVY QRQ*SGAGRSSTVLEPGEGCDWSCRQQSGKL*K ESASQ*DLYKDR*QVNHEDEEWSDVCQGRFETE EACT*WECVSEECSRKVERGSSSSSH*HFSFPSR KRPEVHLCIIGPEVNSDLFKEADCERSGT*GER FIPDQHGDDRSRDGRSPCQLQRGTKQLDSDHSG HNQHPEQR*R*RNS**E*GRKENVGHQSPRIKRT TSPEGPKNPTLVGREGDDFPGHG*VQHPSPRGL LPNT*P*SSLPLQHRRGSQRRTFNEKCNK*GGD PSGFGEWKSGRHTWADCQQPH*ARCGRSRFPAPE SRDLWRI*QPSDECFKRRREGRGR*WPRS*ENG IR*WPKKGWKC*PGIYA*KKQ*AGCPERCSSLR APQRSAGCGAAAGQLH*GPETGAEREGAHSQLVP PELPH*AGEAAQPGEAAPGPGQPAEAAGPVPRG EAQARA*VGSS*EGAAGAGGPPGPARGGGAAGA AGPGKGAGGAPAEEGHIPV*PGATACCPETA*EG TGAAAPGGRAAQPAADRTGPVSGFPSTYQADED PIVLPQS*GAPLAICTFHSQIRVIGLRTFSVPK KEQHLSDTQR*GAFSHTEFNQPDKQRTRRAEPGP CVHLCLYPPVWVNKAKGKEGEKKEEQNQPLSAR *WSRVRSISRG*RDLLLTLFLSAEAAAS*SWPA HLSCCPRVHKSLTLDAHCSSASSPPGRPQVLDNK QQMILSVGWGRRPRLCFGHDL*LPRTLRLGWPY SGLH*K*WPRKYR*WFWTRQEFLKAERVYPSKV *TSECLLFGGTQNQTADVLDLICVRTWGPVCIYT RGMPEEGPVCTRRLVNLAQGQCLDGPGAPAYQQ FTQYSSETGFPLNPSRAHTTRVLHVFLISF*G* QTFVKPVREGLMCIKDVMCTTSISVFQALKQQNN P*YLILSSDPEEISWFSSMFTHMFWPWIK*RGL LTIIPAA*HLLIVTDHSEGATASWLCS*APVVP LPDSSCLALAG*GHTTARGQPRTQARQKLCSEAR TAG*EVGSGEG*SHV*QFLPVQIWRGAGPEGVV VKAPFLC*EALAKLDFFKNTCKGLLLNCTLPLE ADTDGCLLLGFAFAFPTVFSSLFT*GFPQLVCAG QFMVMLPSEAPYTRREALENFVLPTWPSILAFL PLGSMGLLSTLKKRKICNLVLIDELQAGLADGD IYLSVYLKEVWFKICSLHLFYLLYLCVCVCFFLR VSQV*PNSLNYPVNTE*SGSQHCSLCVF*SALK AQMKF*REGVHVLPSPTPPHSLIKGCLLPCLRM KKLATSDLPLPFSVMENTHPSETDQRPKPADFSI ENMSPCKDPKQKVKFLSFTYLYNSKLQLNLS*L S*DLPGAWLSVLGTGSEFPSWDLQEGSTEPAFF SL*M*AGCPCSPGLEQYEVGADGIYLRTCSSQKH RGC*S*STSPQSLTSMLEGLLLPAQL*CFICFG CFGGLF*K*RFHICPDPTQNDLVRFWLDKFKIK VVPGIPSNHPTSSRNTVCSAATEPLTKNCAYIPL SSLFPPWKLSSGGFVPVLGIYLGWWLPVLLLMA LTVL*LLDLMACLGFYHMRRGCFFGVTRTEFPI LFPRRDTMFSIKLKKSRA*NCA*VLGERWSSYPE PPDFQNRVSFLEGDCVFSQFQSSQSLSLGDMCT LNALIGWLHFQDNQMY*LCFLLRKWRGLKTCKL PLSTFASIPSTPVRAIWGEESLPRFFWKGTNLNF FPLLCLRVILFRVAPLLIFSRICYLPEASVLVV STKF*DLWRCFLMWEGRC*CMQGLN*IDPALVE GGTITLEART*SRSCCPQKCFLFHHFCF*GSFSV ARSSQGF*YLHWS*GLL**WWPSCAQRTARQAL GGSLERQSW*MGFKWSQRGWL*GDPRHCRTMCT LCVLDVLGMWEPRNNPVDGIGAAAAGDLCALPSF SRTV*VRSHLWMRPSQPRRSRPSSETKKRAGSL GLVLNFPFNVAKHS*LTRALESTACWPGFKMKS VLMLP*KGGGGEEGKIKASFQVLI*FNCQKIDRP *ITSPSH*GLKACNPPLAVSPATEVSDLPYNQV GPPVLQSGGASAGSTHPPHLPRPELPLPFVTT* GHEHRPWGVPGESACGSGLACGLLCAAARMGCAG EAWGSAGGWLGYTGYLCSHCLFANALWTFVC*I LLNKKDGLKPRCCIFICNYV*SEAVLNCKDFFQ CVFSNFATTYWLRILFIFLSSYQLQTLVKSPSAL SKNNKFPVKFW

Frame 2

QKGKSSPICSTTGDDKLCADSACQQNTVTSSGD LVAKLCDNIVSESESTTARQPSSQDPPDASHCE DPQAHTVTSDPVRDTQERADFCPFKVVDNKGQR KDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQ AVISDSTFSLANSPGSESVTKDDALSFVPSQKE KGTATPELHTATDYRDGPDGNSNEPDTRPLEDR AVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAP PAIPEALNIKGNTDSSLQSVGKATLALDSVLTE EGKLLVVSESSAAQEQDKDKAVTCSSIKENALS SGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKA LQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQ GGAAQSLVPPGASLATESRQEALGAEHNSSALL PCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGK TSACEVSGDVTVDVTGVNALQGMAEPRRENISH NTQDILIPNVLLSQEKNAVLGLPVALQDKAVTD PQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEA QIDDEAHPVLLQPVAKELPTDMELSAHDDGAPA GVREVMRAPPSGRERSTPSLPCMVSAQDAPLPK GADLIEEAASRIVDAVIEQVKAAGALLTEGEACH MSLSSPELGPLTKGLESAFTEKVSTFPPGESLP MGSTPEEATGSLAGCFAGREEPEKIILPVQGPE PAAEMPDVKAEDEVDFRASSISEEVAVGSIAATL KMKQGPMTQAINRENWCTIEPCPDAASLLASKQ SPECENFLDVGLGRECTSKQGVLKRESGSDSDL FHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDD TASLDRHSSHGSDVSLSQILKPNRSRDRQSLDG FYSHGMGAEGRESESEPADPGDVEEEEMDSITE VPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAE MNHRSFSLEGLTGGAGVGNKPSSSLEVSSANAE ELRHPFSGEERVDSLVSLSEEDLESDQREHRMF DQQICHRSKQQGFNYCTSAISSPLTKSISLMTIS HPGLDNSRPFHSTFHNTSANLTESITEENYNFL PHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKK SKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFS SIPVVGPISCSQCMKPFTNKDAYTCANCSAFVH KGCRESLASCAKVKMKQPKGSLQAHDTSSLPTV IMRNKPSQPKERPRSAVLLVDETATTPIFANRRS QQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH STDSLNKISKVNESTESLTDEGTDMNEGQLLGD FEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQE VIYELMQTEFHHVRTLKIMSGVYSQGMMADLLF EQQMVEKLFPCLDELISIHSQFFQRILERKKES LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTY GKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMS SSVVRRLGIPECILLVTQRITKYPVLFQRILQC TKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEK KVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRK KLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ EKDQKYIFASLDQKSTVISLKKLIVREVAHEEKG LFLISMGMTDPEMVEVHASSKEERNSWIQIIQD TINTLNRDEDEGIPSENEEEKKMLDTRARELKE QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDC SPTHSPRVLFRSNTEEALKGGPLMKSAINEVEI LQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPR RAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTE SDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYE LLSALQGVVLQQDSYIEDQKLVLSERALTRSLS RPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEE KRRREREWEARERELREREALLAQREEEVQQGQ QDLEKEREELQQKKGTYQYDLERLRAAQKQLER EQEQLRREAERLSQRQTERDLCQVSHPHTKLMRI PSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPK RNSISRTHKDKGPFHILSSTSQTNKGPEGQSQA PASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPG DGPASEVSAEGEEIFC*PSSSLLRQLPPDPGQP TSPAVPACTSLLHWTPTAPQRPVLLGGPRSWTI SNR*Y*VSGGEGGPDSASAMICDCPGLSGWAGPT QDYTESNGLVSTGDGFGHVRNS*RLKECIQVRS EPPNAFYLGEHKTKQQMFWT*SVYVHGDLSAYT HGECQKKAQSAPGVWST*HKGSAWTDPEPPHISS SPSTPQRLVSL*THPGHIPPVFCMYFSFHFRDD KHL*NQ*EKA*CV*KT*CAPPRSRCFRH*SNKT THSISFCHQIQKKYPGFPACLPTCFGHG*SEEAY SPLSLQRDTF*LSLTTQKGPRPPGCVPEPPSCL SQTAAVWPLLGEGTPLPGVSLAPRPGRSCALKL GQLAEKWVQAKGEAMCSSSCQCRSGEELARKAWL *KRPSYVRRPWQNWISSKIHVKVCC*IVLCPWK QIQMAACCSALLLLFPPCFHLCSLEAFPSWCVQ DSSW*CCPLRPRTPEGRPWKILCFQRGLQFLLFC PSEAWGF*AHLKKEKSVTWCLLMNCKLALQMEI FIFQFI*KRSGLKFVAYICFIYCICVFVFVFF* G*ARSSPTV*TIQSIPSEVAASTVHSVSFEVP*R PR*NFKGRGSMSFPPPPRLIL*SKDVFSLV*E* RNSPPLTYLCLFLSWRILTLQKQTKGQNLLIFL LKICPLAKTLNKKLSFFLSPICTTPSYS*ICRDF PEIYPGLGCLFWALAPSSPPGICRRAVLNLHSS PCKCRPGAPVLRVWNNTRLVLMGFTCVRALHKN TVDAEVRARRHRA*HQC*RVSYSPPSCDVSSALV VLVVFFKNRDFTSAQTPLKTIWSGSGWTSLKSK *CPEFPQTTQLHPGIQSAVQQQNRLPRTVLTYL CHLSSPLGSCPQGDLFLSWGFTWDGGCLCFCSWP *QCSSCWI*WPVLVSIT*EGVVFLG*LGLNSPY CFHAGTPCSPSS*RNHVPETVLKFWGKDGVPIQ SPQISRIE*ASWKETASSLNSSHLSRCR*VTCAL *MLSSVGFIFKTIKCIDCVFFLENGEG*KHANC HFQPLPVFPLPP*ELSGGKNPYQGFFGKVRILT FFPFCVSG*YYSESPLCSFSPVFVTFLRPQY*S* AQSFETFGVVS*CGRGGVSACKG*TR*TLP**R VGL*P*RPELDPEVAVHRSAFYFIIFVSRALFL *PGLPKDFSICIGVEVYSNDGGPAVPRGQPGRPW EGV*KDSPGEWASSGHKEGGCEVTPDTAERCAP SAFWMSLECGSLEITLWMELGQRLLEICVPCLP SAGPSRCAATYGCVPASPVALVHPQRQRRGQGVW AWF*TFLSM*QSIPS*PEPWNLLPAGQALK*KV F*CCHKREAGGRKGK*RHLSKYSSNLIVKRLIG HELLLHLTKG*RRATPHWLCPLPPK*VTCPTTRW DHLCCSPEGLLQEALTPHTFPGLSFPYLSSPPE GMSTGHGACLVSLPVVQA*PVVSCVLLPAWDAQ GRRGDPQEGGWDTPDTSALIACLQMLYGHLCAKS Y*IKKTG*NPDAVYSFVIMYKVKQF*TVKIFFS VFSRILPQHTGFVFYLSFFLVTSFRPL*SLPQP FQKIINFL*SS

Sequence AKAP13.bAug05

TGAGTTGAAGTGGGGGAAATAGAGGAGTAAATCATTTCACGATGTGTGGTTAAGTGCTGCAGCTCAGGTAACCACCAGTACACAGAGGAAGGGCGGTTTC TGGAGACAGGGCGGAGAGGAGACCGTGGGTGGGCATTTCCCAGAGCAGCCTCTGCCAGCCACCCTACTTTGATCACTTTGCCGCCGAGCAGCAGCGGCGG TCAACCTCAGCCTCCCTTAGCAACCTGAGTGCCCCGTCCAGGAGCCTTACTATTGGTCTCATGCAGCGAGATGGGCAGTTCTGCCGTGCAATCCCAGCTC GCAGTTCTTGCTCCGCGTGTACTCACGGGAGGACTCGCAGGCGTTACCGCCTTCCCGCGTGCCCCGCCCACCCTCCCGAGCGTCTTTCGGCGCATGCGCG GACTGGAGCTGTGTGCAGGGCCAGCGCGGAGCCCGAGCAGCCGCGGTGAAGCGCCTGTGCTCTGCCGAGACTGCCGTGCCCATTGCTCGCCTCGGTCGCC GCCGCTTTAGCCGCCTCCGGGGGAGCGGCCGCCTATTGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGC CGCACGTGTCCTGGGTCATGAAACTTAATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGA TGATGTAGTGTTTTACTTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTGCTCCTGGT CATGATTGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACTTTCATTTCGTCCAGGATG AAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTCTTGACCAGTCAGGACCCCCATCTGGGGA TGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGTGGAATGTATTGGGGACAGATCAGAGTTTGCATGATGCT GGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGTTGACGTGGTTCCTGTTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTA TCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGGAGCGAGGCTATCACAAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGA CTCCTGGAGCAGTTTATCCTATGAAATACCGTATGGAGACTGTTCTGTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCA CATCATGAACACCCATTTCCTGGAGACGGTTGCACTGGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGG ACAGTCTTATGCCCTTAATGATGACAGCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCA GCGACTTTCTTCTTCTGAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCATAGTTGAG GAGGAGAATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTGTGGACTCTGGAACTGTAT CTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTGGAAACAGAAATGAAGAAACTGGAACAAA ATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAGACTTGGTCATGGAGCCAGGCACAGCCCAGTATTCCTCT GGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTGCAGGGGAAATGGAACATGGGCTCATGAACCCAGATGCCACTGTTTGGA AGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTGAGAACTCTAATATTGGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGT GGATAAAATCAGTGTTCCAAACTGTGCCCCTGCTGCCAGTTCCCTGGATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCC ACTGAAAAAACAGCAGAAACGGAAACTTCACGAAGTCGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAG ACAAGATTTCAGATGGATTAGAACCTTATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGA TGTAATGCCACACCAGAACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTT TGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACCACAG CAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGGGATACCCAGGAACG TGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAGATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACAT CCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAGTAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAAT CAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAAAAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCC AGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGGGCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGG AATACCAGTCTCACAGGACTTGGTGGAGAGCATGAGGGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGC AAAGTGTGGGTAAGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAA GGATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAA CAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCAGAAA CTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGTCTGGCCACAGAGTC AAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAGATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAG CCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTAGTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTA ATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACACAACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGC CGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGACCCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAG CTGGAGGGAGCAGACCACAGCTGTACCATGGGTGACGCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGC TCCCCACAGACATGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCC CTCTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAA CAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAGAGTG CTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCAGGATGTTTTGCTGG AAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCA AGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTA CAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCAAGCAGAGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTC AAAACAAGGTGTACTTAAAAGAGAATCTGGGAGTGATTCTGACCTCTTTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAA GAGCATTTGGCCTGTGATATCACCGGATCCAGTTCATCCACCGATGACACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCC AGATTTTAAAGCCAAACAGGTCAAGAGATCGGCAAAGCCTTGATGGATTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGC TGACCCAGGCGACGTGGAGGAGGAGGAGATGGACAGTATCACTGAAGTGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTC CGGAGGCACAGCTGGGGGCCTGGGAAAAATGCAGCCAGCGATGCAGAAATGAACCACCGGAGTTCAATGCGAGTTCTTGGGGATGTTGTCAGGAGACCTC CCATTCATAGGAGAAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGGTGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTCTGCAAATGCCGA AGAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTGTCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAACATAGGATGTTT GATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTACATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCATTAATGACAATCA GCCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAATACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAACTATAATTTCCT GCCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAAGTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCTAGCAGCAAGAAG AGCAAAGAAAAGGAAAAAGAAAAAGATAAGATTAAGGAGAAGGAGAAAGATTCTAAAGACAAGGAGAAAGATAAGAAGACTGTCAACGGGCACACTTTCA GTTCCATTCCTGTTGTGGGTCCCATCAGCTGTAGCCAGTGTATGAAGCCCTTCACCAACAAAGATGCCTATACTTGTGCAAATTGCAGTGCTTTTGTCCA CAAAGGCTGCCGAGAAAGTCTAGCCTCCTGTGCAAAGGTCAAAATGAAGCAGCCCAAAGGGAGCCTTCAGGCACATGACACATCATCACTGCCCACGGTC ATTATGAGAAACAAGCCCTCACAGCCCAAGGAGCGTCCTCGGTCCGCAGTCCTCCTGGTGGATGAAACCGCTACCACCCCAATATTTGCCAATAGACGAT CCCAGCAGAGTGTCTCGCTCTCCAAAAGTGTCTCCATACAGAACATTACTGGAGTTGGCAATGATGAGAACATGTCAAACACCTGGAAATTCCTGTCTCA TTCAACAGACTCACTAAATAAAATCAGCAAGGTCAATGAGTCAACAGAATCACTTACTGATGAGGGAGTAGGTACAGACATGAATGAAGGACAACTACTG GGAGACTTTGAGATTGAGTCCAAACAGCTGGAAGCAGAGTCTTGGAGTCGGATAATAGACAGCAAGTTTCTAAAACAGCAAAAGAAAGATGTGGTCAAAC GGCAAGAAGTAATATATGAGTTGATGCAGACAGAGTTTCATCATGTCCGCACTCTCAAGATCATGAGTGGTGTGTACAGCCAGGGGATGATGGCGGATCT GCTTTTTGAGCAGCAGATGGTAGAAAAGCTGTTCCCCTGTTTGGATGAGCTGATCAGTATCCATAGCCAATTCTTCCAGAGGATTCTGGAGCGGAAGAAG GAGTCTCTGGTGGATAAAAGTGAAAAGAACTTTCTCATCAAGAGGATAGGGGATGTGCTTGTAAATCAGTTTTCAGGTGAGAATGCAGAACGTTTAAAGA AGACATATGGCAAGTTTTGTGGGCAACATAACCAGTCTGTAAACTACTTCAAAGACCTTTATGCCAAGGATAAGCGTTTTCAAGCCTTTGTAAAGAAGAA GATGAGCAGTTCAGTTGTTAGAAGGCTTGGAATTCCAGAGTGCATATTGCTTGTAACTCAGCGGATTACCAAGTACCCAGTTTTATTCCAAAGAATATTG CAGTGTACCAAAGACAATGAAGTGGAGCAGGAAGATCTAGCACAGTCCTTGAGCCTGGTGAAGGATGTGATTGGAGCTGTAGACAGCAAAGTGGCAAGTT ATGAAAAGAAAGTGCGTCTCAATGAGATTTATACAAAGACAGATAGCAAGTCAATCATGAGGATGAAGAGTGGTCAGATGTTTGCCAAGGAAGATTTGAA ACGGAAGAAGCTTGTACGTGATGGGAGTGTGTTTCTGAAGAATGCAGCAGGAAGGTTGAAAGAGGTTCAAGCAGTTCTTCTCACTGACATTTTAGTTTTC CTTCAAGAAAAAGACCAGAAGTACATCTTTGCATCATTGGACCAGAAGTCAACAGTGATCTCTTTAAAGAAGCTGATTGTGAGAGAAGTGGCACATGAGG AGAAAGGTTTATTCCTGATCAGCATGGGGATGACAGATCCAGAGATGGTAGAAGTCCATGCCAGCTCCAAAGAGGAACGAAACAGCTGGATTCAGATCAT TCAGGACACAATCAACACCCTGAACAGAGATGAAGATGAAGGAATTCCTAGTGAGAATGAGGAAGAAAAGAAAATGTTGGACACCAGAGCCCGAGAATTA AAAGAACAACTTCACCAGAAGGACCAAAAAATCCTACTCTTGTTGGAAGAGAAGGAGATGATTTTCCGGGACATGGCTGAGTGCAGCACCCCTCTCCCAG AGGATTGCTCCCCAACACATAGCCCTAGAGTTCTCTTCCGCTCCAACACAGAAGAGGCTCTCAAAGGAGGACCTTTAATGAAAAGTGCAATAAATGAGGT GGAGATCCTTCAGGGTTTGGTGAGTGGAAATCTGGGAGGCACACTTGGGCCGACTGTCAGCAGCCCCATTGAGCAAGATGTGGTCGGTCCCGTTTCCCTG CCCCGGAGAGCAGAGACCTTTGGAGGATTTGACAGCCATCAGATGAATGCTTCAAAAGGAGGCGAGAAGGAAGAGGGAGATGATGGCCAAGATCTTAGGA GAACGGAATCAGATAGTGGCCTAAAAAAGGGTGGAAATGCTAACCTGGTATTTATGCTTAAAAGAAACAGTGAGCAGGTTGTCCAGAGCGTTGTTCATCT CTACGAGCTCCTCAGCGCTCTGCAGGGTGTGGTGCTGCAGCAGGACAGCTACATTGAGGACCAGAAACTGGTGCTGAGCGAGAGGGCGCTCACTCGCAGC TTGTCCCGCCCGAGCTCCCTCATTGAGCAGGAGAAGCAGCGCAGCCTGGAGAAGCAGCGCCAGGACCTGGCCAACCTGCAGAAGCAGCAGGCCCAGTACC TCGAGGAGAAGCGCAGGCGCGAGCGTGAGTGGGAAGCTCGTGAGAGGGAGCTGCGGGAGCGGGAGGCCCTCCTGGCCCAGCGCGAGGAGGAGGTGCAGCA GGGGCAGCAGGACCTGGAAAAGGAGCGGGAGGAGCTCCAGCAGAAGAAGGGCACATACCAGTATGACCTGGAGCGACTGCGTGCTGCCCAGAAACAGCTT GAGAGGGAACAGGAGCAGCTGCGCCGGGAGGCAGAGCGGCTCAGCCAGCGGCAGACAGAACGGGACCTGTGTCAGGTTTCCCATCCACATACCAAGCTGA TGAGGATCCCATCGTTCTTCCCCAGTCCTGAGGAGCCCCCCTCGCCATCTGCACCTTCCATAGCCAAATCAGGGTCATTGGACTCAGAACTTTCAGTGTC CCCAAAAAGGAACAGCATCTCTCGGACACACAAAGATAAGGGGCCTTTTCACATACTGAGTTCAACCAGCCAGACAAACAAAGGACCAGAAGGGCAGAGC CAGGCCCCTGCGTCCACCTCTGCCTCTACCCGCCTGTTTGGGTTAACAAAGCCAAAGGAAAAGAAGGAGAAAAAAAAGAAGAACAAAACCAGCCGCTCTC AGCCCGGTGATGGTCCCGCGTCAGAAGTATCAGCAGAGGGTGAAGAGATCTTCTGCTGACCCTCTTCCTCTCTGCTGAGGCAGCTGCCTCCTGATCCTGG CCAGCCCACCTCTCCTGCTGTCCCCGCGTGCACAAGTCTCTTACACTGGACGCCCACTGCTCCTCAGCGTCCAGTCCTCCTGGGCGGCCCCAGGTCCTGG ACAATAAGCAACAGATGATATTGAGTGTCGGGTGGGGAAGGAGGCCCAGACTCTGCTTCGGCCATGATTTGTGACTGCCCAGGACTCTCAGGTTGGGCTG GCCCTACTCAGGATTACACTGAAAGTAATGGCCTCGTAAGTACAGGTGATGGTTTTGGACACGTCAGGAATTCCTAAAGGCTGAAAGAGTGTATCCAAGT AAGGTCTGAACCTCCGAATGCCTTTTATTTGGGGGAACACAAAACCAAACAGCAGATGTTTTGGACTTGATCTGTGTACGTACATGGGGACCTGTCTGCA TATACACACGGGGAATGCCAGAAGAAGGCCCAGTCTGCACCAGGCGTCTGGTCAACTTAGCACAAGGGCAGTGCCTGGACGGACCCGGAGCCCCCGCATA TCAGCAGTTCACCCAGTACTCCTCAGAGACTGGTTTCCCTCTAAACCCATCCCGGGCACATACCACCCGTGTTTTGCATGTATTTCTCATTTCATTTTAG GGATGACAAACATTTGTGAAACCAGTGAGAGAAGGCTTGATGTGTATAAAAGACGTGATGTGCACCACCTCGATCTCGGTGTTTCAGGCACTAAAGCAAC AAAACAACCCATAGTATCTCATTCTGTCATCAGATCCAGAAGAAATATCCTGGTTTTCCAGCATGTTTACCCACATGTTTTGGCCATGGATAAAGTGAAG AGGCCTACTCACCATTATCCCTGCAGCGTGACACCTTTTGATTGTCACTGACCACTCAGAAGGGGCCACGGCCTCCTGGCTGTGTTCCTGAGCCCCCGTC GTGCCTCTCCCAGACAGCAGCTGTCTGGCCCTTGCTGGGTGAGGGCACACCACTGCCAGGGGTCAGCCTCGCACCCAGGCCAGGCAGAAGCTGTGCTCTG AAGCTAGGACAGCTGGCTGAGAAGTGGGTTCAGGCGAAGGGTGAAGCCATGTGTAGCAGTTCCTGCCAGTGCAGATCTGGAGAGGAGCTGGCCCGGAAGG CGTGGTTGTGAAAGCGCCCTTCTTATGTTAGGAGGCCTTGGCAAAATTGGATTTCTTCAAAAATACATGTAAAGGTCTGTTGTTGAATTGTACTCTGCCC CTGGAAGCAGATACAGATGGCTGCCTGCTGCTCGGCTTTGCTTTTGCTTTTCCCACCGTGTTTTCATCTTTGTTCACTTGAGGCTTTCCCCAGCTGGTGT GTGCAGGACAGTTCATGGTAATGTTGCCCTCTGAGGCCCCGTACACCAGAAGGGAGGCCCTGGAAAATTTTGTGCTTCCAACGTGGCCTTCAATTCTTGC TTTTTTGCCCCTCGGAAGCATGGGGCTTTTGAGCACACTTAAAAAAAGAAAAATCTGTAACTTGGTGCTTATTGATGAATTGCAAGCTGGCCTTGCAGAT GGAGATATTTATCTTTCAGTTTATTTGAAAGAGGTCTGGTTTAAAATTTGTAGCCTACATTTGTTTTATTTATTGTATTTGTGTGTTTGTGTTTGTTTTT TTTTAAGGGTGAGCCAGGTCTAGCCCAACAGTCTAAACTATCCAGTCAATACCGAGTGAAGTGGCAGCCAGCACTGTTCACTCTGTGTCTTTTGAAGTGC CTTGAAGGCCCAGATGAAATTTTAAAGGGAGGGGGTCCATGTCCTTCCCTCCCCCACCCCGCCTCATTCTTTAATCAAAGGATGTCTTCTCCCTTGTTTG AGAATGAAGAAACTCGCCACCTCTGACCTACCTTTGCCTTTTTCTGTCATGGAGAATACTCACCCTTCAGAAACAGACCAAAGGCCAAAACCTGCTGATT TTTCTATTGAAAATATGTCCCCTTGCAAAGACCCTAAACAAAAAGTTAAGTTTCTTTCTTTCACCTATTTGTACAACTCCAAGTTACAGCTGAATCTGTC GTGACTTTCCTGAGATCTACCCGGGGCTTGGCTGTCTGTTCTGGGCACTGGCTCCGAGTTCCCCTCCTGGGATTTGCAGGAGGGCAGTACTGAACCTGCA TTCTTCTCCTTGTAAATGTAGGCCGGGTGCCCCTGTTCTCCGGGTTTGGAACAATACGAGGTTGGTGCTGATGGGATTTACTTGCGTACGTGCTCTTCAC AAAAACACCGTGGATGCTGAAGTTAGAGCACGTCGCCACAGAGCTTGACATCAATGTTAGAGGGTCTCTTACTCCCCGCCCAGCTGTGATGTTTCATCTG CTTTGGTTGTTTTGGTGGTCTTTTTTAAAAATAGAGATTTCACATCTGCCCAGACCCCACTCAAAACGATTTGGTCAGGTTCTGGTTGGACAAGTTTAAA ATCAAAGTAGTGCCCGGAATTCCCTCAAACCACCCAACTTCATCCAGGAATACAGTCTGCAGTGCAGCAACAGAACCGCTTACCAAGAACTGTGCTTACA TACCTTTGTCATCTCTCTTCCCCCCTTGGAAGTTGTCCTCAGGGGGATTTGTTCCTGTCCTGGGGATTTACCTGGGATGGTGGCTGCCTGTGCTTTTGCT CATGGCCTTGACAGTGCTCTAGTTGCTGGATCTAATGGCCTGTCTTGGTTTCTATCACATGAGAAGGGGTTGTTTTTTTGGGGTGACTCGGACTGAATTC CCCATACTGTTTCCACGCCGGGACACCATGTTCTCCATCAAGCTAAAGAAATCACGTGCCTGAAACTGTGCTTAAGTTTTGGGGGAAAGATGGAGTTCCT ATCCAGAGCCCCCAGATTTCCAGAATCGAGTGAGCTTCCTGGAAGGAGACTGCGTCTTCTCTCAATTCCAGTCATCTCAGTCGTTGTCGTTAGGTGACAT GTGCACTTTAAATGCTCTCATCGGTTGGCTTCATTTTCAAGACAATCAAATGTATTGACTGTGTTTTCTTCTTAGAAAATGGAGAGGGTTAAAAACATGC AAACTGCCACTTTCAACCTTTGCCAGTATTCCCTCTACCCCCGTGAGAGCTATCTGGGGGGAAGAATCCTTACCAAGGTTTTTTTGGAAAGGTACGAATC TTAACTTTTTTCCCCTTCTGTGTCTCAGGGTAATACTATTCAGAGTCGCCCCTTTGCTCATTTTCTCCCGTATTTGTTACCTTCCTGAGGCCTCAGTATT AGTCGTGAGCACAAAGTTTTGAGACCTTTGGCGTTGTTTCTTGATGTGGGAGGGGAGGTGTTAGTGCATGCAAGGGTTGAACTAGATAGACCCTGCCTTA GTAGAGGGTGGGACTATAACCTTAGAGGCCAGAACTTGATCCAGAAGTTGCTGTCCACAGAAGTGCTTTCTATTTCATCATTTTTGTTTCTAGGGCTCTT TTTCTGTAGCCAGGTCTTCCCAAGGATTTTAGTATTTGCATTGGAGTTGAGGTTTACTCTAATGATGGTGGCCCAGCTGTGCCCAGAGGACAGCCAGGCA GGCCCTGGGAGGGAGTTTAGAAAGACAGTCCTGGTGAATGGGCTTCAAGTGGTCACAAAGAGGGTGGCTGTGAGGTGACCCCAGACACTGCAGAACGATG TGCACCCTCTGCGTTTTGGATGTCCTTGGAATGTGGGAGCCTAGAAATAACCCTGTGGATGGAATTGGGGCAGCGGCTGCTGGAGATCTGTGTGCCTTGC CTTCCTTCAGCAGGACCGTCTAGGTGCGCAGCCACCTATGGATGCGTCCCAGCCAGCCCCGTCGCTCTCGTCCATCCTCAGAGACAAAGAAGAGGGCAGG GAGTTTGGGCTTGGTTTTGAACTTTCCTTTCAATGTAGCAAAGCATTCCTAGTTAACCAGAGCCTTGGAATCTACTGCCTGCTGGCCAGGCTTTAAAATG AAAAGTGTTTTAATGCTGCCATAAAAGGGAGGCGGGGGGGAGGAAGGGAAAATAAAGGCATCTTTCCAAGTACTCATCTAATTTAATTGTCAAAAGATTG ATAGGCCATGAATTACTTCTCCATCTCACTAAGGGTTAAAGGCGTGCAACCCCCCACTGGCTGTGTCCCCTGCCACCGAAGTGAGTGACCTGCCCTACAA CCAGGTGGGACCACCTGTGCTGCAGTCCGGAGGGGCTTCTGCAGGAAGCACTCACCCCCCACACCTTCCCCGGCCTGAGCTTCCCCTACCTTTCGTCACC ACCTGAGGGCATGAGCACAGGCCATGGGGCGTGCCTGGTGAGTCTGCCTGTGGTTCAGGCTTAGCCTGTGGTCTCCTGTGTGCTGCTGCCCGCATGGGAT GCGCAGGGGAGGCGTGGGGATCCGCAGGAGGGTGGTTGGGATACACCGGATACCTCTGCTCTCATTGCTTGTTTGCAAATGCTCTATGGACATTTGTGTG CTAAATCCTATTAAATAAAAAAGACGGGTTAAAACCCAGATGCTGTATATTCATTTGTAATTATGTATAAAGTGAAGCAGTTTTAAACTGTAAAGATTTT TTTCAGTGTGTTTTCTCGAATTTTGCCACAACATACTGGCTTCGTATTTTATTTATCTTTCTTTCTAGTTACCAGCTTCAGACCCTTGTAAAGTCTCCCT CAGCCCTTTCAAAAAATAATAAATTTCCTGTGAAGTTCTGG

AKAP13-F1 (forward primer)
AKAP13-R1 (reverse primer)
Single exon skipping

Frame 0

*VEVGEIEE*IISRCVVKCCSSGNHQYTEEGRF LETGRRGDRGWAFPRAASASHPTLITLPPSSSGG QPQPPLAT*VPRPGALLLVSCSEMGSSAVQSQL AVLAPRVLTGGLAGVTAFPRAPPTLPSVFRRMR GLELCAGPARSPSSRGEAPVLCRDCRAHCSPRSP PL*PPPGERPPIVFLRGEGEELSQLGPRGSPGS RTCPGS*NLIHSKLPYMVIVLLQCCLLKRTKLK MM*CFTWYFWVPPSVTVQVLGRSVLIHWRPLLLV MIVVKQ*RCSSVLPKRAFPCLWWLKKTFISSRM KRMMQLNS*QPVLEISRL*TLPVFLTSQDPHLG M*IPLIRSWCWHSGT*SCPRSGMYWGQIRVCMML ARERH*CILLCGWDC*G*RGSCCRSQVAAELSV STTRKGRRL*AWPWSEAITSCTSF*PRRMLENQ TPGAVYPMKYRMETVL*GIIESWTSIH*PLSLIH IMNTHFLETVALDQFLNL*TSNSN**KQTSSRW TVLCP***QHRILPVPQRQMASFFPVHRSPRTL SDFLLLKRLRALSAAQGALLHRLKVPVICQA*LR RRIQTVPVGRKIKAWKEKGKRWSQHLLWTLELY LIKTAAFRACLIVE*RARKAFRPVETEMKKLEQ NLLECPQTRSP*AVEMLCFRETWSWSQAQPSIPL EVNWEAFQQQMSVPQTLQGKWNMGS*TQMPLFG RMCFREGKVQRKDLRTLILAQLEPLTCTSQVSL WIKSVFQTVPLLPVPWMVTNLLSLHLHLVMKKPP LKKQQKRKLHEVVRRVLMLQ*IRILW*FQLLQK TRFQMD*NLILS*QQA*VRQCHPQI*PFLGWKK M*CHTRTQKQIHLMLKAKRANPHPFVLQLETINF VQTLHVNRTQ*LLVAIWLQNCVIT*LASPKAPQ QGNPAHKIHPMPPTVKTHRLIQSPLTL*GIPRN VRIFVLSKWWITKANEKM*N*INL*QICLRWFHI HIQLSLKWRKNWCQTRQ*YQTVLSLWQTVQAVN Q*PRMTHFLLSPPRKKREQQLLNYIQLQIIEMA QMEIRMSLIRGH*KTGQ*ACPHPPLLQSFSTGWG IPVSQDLVESMRVPPLQQSQKL*ISRGTLTLPC KVWVRPLWL*IQF*LKKENFWWFQKALQLRNKI RIKR*PVPLLRKMLSLQELCRKSREHHLLDKILN NFMKNQSQLTVPRTKHFS*VIHRVHPLPFLRQK LNITRKWPHKSHC*LKVGLPRAWCHQEQVWPQS QGRKPWGQSTTAPLCCHVCCQMGLMGPMLLTAVS LLLWMLE*RTLNPREKLVPVR*VEM*RWMLQGL MLYKVWLSPEERIYHTTPKTS*FQTSC*AKRRM PF*VCQWLYRTKL*LTHRELEPQR*YLLIGRKGS WREQTTAVPWVTLRKPK*TMKHILSYCSLLPRS SPQTWSSQPMMMGPQLV*GKSCEPRLQAGKGAL PLYLAWSLPRTHLCLRGQT**RRLPAV*WMLSSN KSRPLEHCLLRGRPVTCHCPALSWVLSLKD*RV LLQKK*VLSHLGRAYQWAVLLRKPRGALQDVLL EGRSQRRSFYLSRGLSQQQKCQT*KLKMKWILEQ VQFLKKWL*GA*LLH*R*SKAQ*PRR*TEKTGV Q*SHALMQHLFWLPSRAQNVRTSWMLDWAESVP QNKVYLKENLGVILTSFTHPVMTWTASSSQSQRK SIWPVISPDPVHPPMTRLHWTDILLMAVMCLSP RF*SQTGQEIGKALMDSTAMGWELRVEKVRVSL LTQATWRRRRWTVSLKCLQTALS*GAPCALFLPS GGTAGGLGKMQPAMQK*TTGVQCEFLGMLSGDL PFIGEVSV*KA*QEELVSETSHPHL*K*ALQMP KSSDTHSVVRNGLTLWCHFQKRIWSQTRENIGCL ISRYVTDLSSRDLITVHQPFPLH*QNPSH**QS AILDWTIHGPSTVPSTIPVLI*LRV*QKRTIIS CHIAPPRKILNGRVEQKSVVHSATSRIKCLAARR AKKRKKKKIRLRRRRKILKTRRKIRRLSTGTLS VPFLLWVPSAVASV*SPSPTKMPILVQIAVLLS TKAAEKV*PPVQRSK*SSPKGAFRHMTHHHCPRS L*ETSPHSPRSVLGPQSSWWMKPLPPQYLPIDD PSRVSRSPKVSPYRTLLELAMMRTCQTPGNSCL IQQTH*IKSARSMSQQNHLLMRE*VQT*MKDNYW ETLRLSPNSWKQSLGVG**TASF*NSKRKMWSN GKK*YMS*CRQSFIMSALSRS*VVCTARG*WRI CFLSSRW*KSCSPVWMS*SVSIANSSRGFWSGRR SLWWIKVKRTFSSRG*GMCL*ISFQVRMQNV*R RHMASFVGNITSL*TTSKTFMPRISVFKPL*RR R*AVQLLEGLEFQSAYCL*LSGLPSTQFYSKEYC SVPKTMKWSRKI*HSP*AW*RM*LEL*TAKWQV MKRKCVSMRFIQRQIASQS*G*RVVRCLPRKI* NGRSLYVMGVCF*RMQQEG*KRFKQFFSLTF*FS FKKKTRSTSLHHWTRSQQ*SL*RS*L*EKWHMR RKVYS*SAWG*QIQRW*KSMPAPKRNETAGFRS FRTQSTP*TEMKMKEFLVRMRKKRKCWTPEPEN* KNNFTRRTKKSYSCWKRRR*FSGTWLSAAPLSQ RIAPQHIALEFSSAPTQKRLSKEDL**KVQ*MR WRSFRVW*VEIWEAHLGRLSAAPLSKMWSVPFPC PGEQRPLEDLTAIR*MLQKEARRKREMMAKILG ERNQIVA*KRVEMLTWYLCLKETVSRLSRALFI STSSSALCRVWCCSRTATLRTRNWC*ARGRSLAA CPARAPSLSRRSSAAWRSSARTWPTCRSSRPST SRRSAGASVSGKLVRGSCGSGRPSWPSARRRCS RGSRTWKRSGRSSSRRRAHTSMTWSDCVLPRNSL RGNRSSCAGRQSGSASGRQNGTCVRFPIHIPS* *GSHRSSPVLRSPPRHLHLP*PNQGHWTQNFQC PQKGTASLGHTKIRGLFTY*VQPARQTKDQKGRA RPLRPPLPLPACLG*QSQRKRRRKKRRTKPAAL SPVMVPRQKYQQRVKRSSADPLPLC*GSCLLIL ASPPLLLSPRAQVSYTGRPLLLSVQSSWAAPGPG Q*ATDDIECRVGKEAQTLLRP*FVTAQDSQVGL ALLRITLKVMAS*VQVMVLDTSGIPKG*KSVSK *GLNLRMPFIWGNTKPNSRCFGLDLCTYMGTCLH IHTGNARRRPSLHQASGQLSTRAVPGRTRSPRI SAVHPVLLRDWFPSKPIPGTYHPCFACISHFIL GMTNICETSERRLDVYKRRDVHHLDLGVSGTKAT KQPIVSHSVIRSRRNILVFQHVYPHVLAMDKVK RPTHHYPCSVTPFDCH*PLRRGHGLLAVFLSPR RASPRQQLSGPCWVRAHHCQGSASHPGQAEAVL* S*DSWLRSGFRRRVKPCVAVPASADLERSWPGR RGCESALLMLGGLGKIGFLQKYM*RSVVELYSA PGSRYRWLPAARLCFCFSHRVFIFVHLRLSPAGV CRTVHGNVAL*GPVHQKGGPGKFCASNVAFNSC FFAPRKHGAFEHT*KKKNL*LGAY**IASWPCR WRYLSFSLFERGLV*NL*PTFVLFIVFVCLCLFF FKGEPGLAQQSKLSSQYRVKWQPALFTLCLLKC LEGPDEILKGGGPCPSLPHPASFFNQRMSSPLF ENEETRHL*PTFAFFCHGEYSPFRNRPKAKTC*F FY*KYVPLQRP*TKS*VSFFHLFVQLQVTAESV VTFLRSTRGLAVCSGHWLRVPLLGFAGGQY*TC ILLLVNVGRVPLFSGFGTIRGWC*WDLLAYVLFT KTPWMLKLEHVATELDINVRGSLTPRPAVMFHL LWLFWWSFLKIEISHLPRPHSKRFGQVLVGQV* NQSSARNSLKPPNFIQEYSLQCSNRTAYQELCLH TFVISLPPLEVVLRGICSCPGDLPGMVAACAFA HGLDSALVAGSNGLSWFLSHEKGLFFWGDSD*I PHTVSTPGHHVLHQAKEITCLKLCLSFGGKMEFL SRAPRFPESSELPGRRLRLLSIPVISVVVVR*H VHFKCSHRLASFSRQSNVLTVFSS*KMERVKNM QTATFNLCQYSLYPRESYLGGRILTKVFLERYES *LFSPSVSQGNTIQSRPFAHFLPYLLPS*GLSI SREHKVLRPLALFLDVGGEVLVHARVELDRPCL SRGWDYNLRGQNLIQKLLSTEVLSISSFLFLGLF FCSQVFPRILVFALELRFTLMMVAQLCPEDSQA GPGREFRKTVLVNGLQVVTKRVAVR*PQTLQND VHPLRFGCPWNVGA*K*PCGWNWGSGCWRSVCLA FLQQDRLGAQPPMDASQPAPSLSSILRDKEEGR EFGLGFELSFQCSKAFLVNQSLGIYCLLARL*N EKCFNAAIKGRRGGGRENKGIFPSTHLI*LSKD* *AMNYFSISLRVKGVQPPTGCVPCHRSE*PALQ PGGTTCAAVRRGFCRKHSPPTPSPA*ASPTFRH HLRA*AQAMGRAW*VCLWFRLSLWSPVCCCPHGM RRGGVGIRRRVVGIHRIPLLSLLVCKCSMDICV LNPIK*KRRVKTQMLYIHL*LCIK*SSFKL*RF FSVCFLEFCHNILASYFIYLSF*LPASDPCKVSL SPFKK**ISCEVL

Frame 1

ELKWGK*RSKSFHDVWLSAAAQVTTSTQRKGGF WRQGGEETVGGHFPEQPLPATLL*SLCRRAAAA VNLSLP*QPECPVQEPYYWSHAARWAVLPCNPSS QFLLRVYSREDSQALPPSRVPRPPSRASFGACA DWSCVQGQRGARAAAVKRLCSAETAVPIARLGR RRFSRLRGSGRLLSFSAAKVKSCPSSARGGAPGA ARVLGHET*STASSLIW*LCCYSAAC*RGQS*R *CSVLLGIFGFHPPSLYKYSEGQF*YIGDHCSW S*LL*NSEGAALCFQRGPSRVCGG*RRLSFRPG* SV*CSSIPSNQCWKSAGFELYPFS*PVRTPIWG CEFP**EVGAGIQAPEAAHGVECIGDRSEFA*C WPARDIDAFCCAAGTAEVDVVPVAEARWPRSSQY PQPGRGDACELGLGARLSQAAPASNRGECWRTR LLEQFIL*NTVWRLFCEASSRVGHLYINL*V*F TS*TPISWRRLHWTNF*TYEHPTATNENKPQADG QSYALNDDSTGSFQCPRDRWPVSSLCTGAHGPS ATFFF*RD*EHSVLPREPCCTD*KSL*FVKHS* GGEYRPFL*EEK*RRGKKRGRGGASTYCGLWNCI *SRQLPSELA*LWSKGHGRPFVLWKQK*RNWNK IFWNAHRPGVPEQWRCCASERLGHGARHSPVFL WR*TGRHFNNKCQYPRHCRGNGTWAHEPRCHCLE ECASGRGKYKGKI*EL*YWHSWSL*RARHK*AC G*NQCSKLCPCCQFPGW*QTC*VFTCI***RNL H*KNSRNGNFTKS*GEC*CSSRSEFCGDSSCCKR QDFRWIRTLYSLSSRHR*GNVTLRFSPSWAGRR CNATPELRNKFISCSKPKGQILTHLFYNWRR*T LCRLCMSTEHSDF*WRFGCKTV**HS*RVRKHHS KATQLTRSTRCLPL*RPTGSYSHL*PCKGYPGT CGFLSFQSGG*QRPTKRCETR*TFNKYA*GGFT STSSCP*NGERTGARPGSNIRQYFLSGKQSRQ*I SNQG*RTFFCPLPERKGNSNS*TTYSYRL*RWP RWKFE*A*YAATRRQGSRPVHILHCCRASARDG EYQSHRTWWRA*GSRPSSNPRSSEYQGEH*LFPA KCG*GHFGFRFSFD*RRKTSGGFRKLCSSGTR* G*SGDLFLY*GKCSLFRNFAGRAENTTSWTRYS TIS*KINLS*LCQGQSTSAK*FTGCILCLS*GRN *T*QGSGPTSLTADSRWGCPEPGATRSKSGHRV KAGSLGGRAQQLRSVAMSVARWV*WVRCS*LQS AFSSGCWSEEHSIPGKN*CL*GEWRCDGGCYRG* CSTRYG*AQKREYITQHPRHPDSKRLVEPREEC RSRFASGSTGQSCD*PTGSWNPRDDTS*LGERE AGGSRPQLYHG*R*GSPNRR*STSCPTAACCQGA PHRHGALSP**WGPSWCEGSHASPAFRQGKEHS LSTLHGLCPGRTSA*GGRLDRGGCQPYSGCCHR TSQGRWSTAY*GGGLSHVTVQP*VGSSH*RTREC FYRKSEYFPTWGEPTNGQYS*GSHGEPCRMFCW KGGAREDHFTCPGA*ASSRNARRES*R*SGF*S KFNF*RSGCREHSCYTEDEARPNDPGDKPRKLVY NRAMP*CSISSGFQAEPRM*ELPGCWTGQRVYL KTRCT*KRIWE*F*PLSLTQ**HGQHHLPKARG RAFGL*YHRIQFIHR*HGFTGPTFFSWQ*CVSLP DFKAKQVKRSAKP*WILQPWDGS*GSRK*E*AC *PRRRGGGGDGQYH*SACKLLCPKELHALSFSL PEAQLGAWEKCSQRCRNEPPEFNASSWGCCQETS HS*EKFQSRRLDRRSWCRKQAILISRSKLCKCR RAQTPIQW*GTG*LFGVTFRRGSGVRPERT*DV *SADMSQI*AAGI*LLYISHFLSIDKIHLINDNQ PSWIGQFTALPQYLPQYQC*SD*EYNRREL*FP AT*PLQERF*MEEWNKSQSYIQLHQE*NV*QQE EQRKGKRKR*D*GEGERF*RQGER*EDCQRAHFQ FHSCCGSHQL*PVYEALHQQRCLYLCKLQCFCP QRLPRKSSLLCKGQNEAAQREPSGT*HIITAHG HYEKQALTAQGASSVRSPPGG*NRYHPNICQ*TI PAECLALQKCLHTEHYWSWQ**EHVKHLEIPVS FNRLTK*NQQGQ*VNRITY**GSRYRHE*RTTT GRL*D*VQTAGSRVLESDNRQQVSKTAKERCGQT ARSNI*VDADRVSSCPHSQDHEWCVQPGDDGGS AF*AADGRKAVPLFG*ADQYP*PILPEDSGAEE GVSGG*K*KELSHQEDRGCACKSVFR*ECRTFKE DIWQVLWAT*PVCKLLQRPLCQG*AFSSLCKEE DEQFSC*KAWNSRVHIACNSADYQVPSFIPKNI AVYQRQ*SGAGRSSTVLEPGEGCDWSCRQQSGKL *KESASQ*DLYKDR*QVNHEDEEWSDVCQGRFE TEEACT*WECVSEECSRKVERGSSSSSH*HFSF PSRKRPEVHLCIIGPEVNSDLFKEADCERSGT*G ERFIPDQHGDDRSRDGRSPCQLQRGTKQLDSDH SGHNQHPEQR*R*RNS**E*GRKENVGHQSPRI KRTTSPEGPKNPTLVGREGDDFPGHG*VQHPSPR GLLPNT*P*SSLPLQHRRGSQRRTFNEKCNK*G GDPSGFGEWKSGRHTWADCQQPH*ARCGRSRFP APESRDLWRI*QPSDECFKRRREGRGR*WPRS*E NGIR*WPKKGWKC*PGIYA*KKQ*AGCPERCSS LRAPQRSAGCGAAAGQLH*GPETGAEREGAHSQ LVPPELPH*AGEAAQPGEAAPGPGQPAEAAGPVP RGEAQARA*VGSS*EGAAGAGGPPGPARGGGAA GAAGPGKGAGGAPAEEGHIPV*PGATACCPETA *EGTGAAAPGGRAAQPAADRTGPVSGFPSTYQAD EDPIVLPQS*GAPLAICTFHSQIRVIGLRTFSV PKKEQHLSDTQR*GAFSHTEFNQPDKQRTRRAE PGPCVHLCLYPPVWVNKAKGKEGEKKEEQNQPLS AR*WSRVRSISRG*RDLLLTLFLSAEAAAS*SW PAHLSCCPRVHKSLTLDAHCSSASSPPGRPQVL DNKQQMILSVGWGRRPRLCFGHDL*LPRTLRLGW PYSGLH*K*WPRKYR*WFWTRQEFLKAERVYPS KV*TSECLLFGGTQNQTADVLDLICVRTWGPVC IYTRGMPEEGPVCTRRLVNLAQGQCLDGPGAPAY QQFTQYSSETGFPLNPSRAHTTRVLHVFLISF* G*QTFVKPVREGLMCIKDVMCTTSISVFQALKQ QNNP*YLILSSDPEEISWFSSMFTHMFWPWIK*R GLLTIIPAA*HLLIVTDHSEGATASWLCS*APV VPLPDSSCLALAG*GHTTARGQPRTQARQKLCS EARTAG*EVGSGEG*SHV*QFLPVQIWRGAGPEG VVVKAPFLC*EALAKLDFFKNTCKGLLLNCTLP LEADTDGCLLLGFAFAFPTVFSSLFT*GFPQLV CAGQFMVMLPSEAPYTRREALENFVLPTWPSILA FLPLGSMGLLSTLKKRKICNLVLIDELQAGLAD GDIYLSVYLKEVWFKICSLHLFYLLYLCVCVCF FLRVSQV*PNSLNYPVNTE*SGSQHCSLCVF*SA LKAQMKF*REGVHVLPSPTPPHSLIKGCLLPCL RMKKLATSDLPLPFSVMENTHPSETDQRPKPAD FSIENMSPCKDPKQKVKFLSFTYLYNSKLQLNLS *LS*DLPGAWLSVLGTGSEFPSWDLQEGSTEPA FFSL*M*AGCPCSPGLEQYEVGADGIYLRTCSS QKHRGC*S*STSPQSLTSMLEGLLLPAQL*CFIC FGCFGGLF*K*RFHICPDPTQNDLVRFWLDKFK IKVVPGIPSNHPTSSRNTVCSAATEPLTKNCAY IPLSSLFPPWKLSSGGFVPVLGIYLGWWLPVLLL MALTVL*LLDLMACLGFYHMRRGCFFGVTRTEF PILFPRRDTMFSIKLKKSRA*NCA*VLGERWSS YPEPPDFQNRVSFLEGDCVFSQFQSSQSLSLGDM CTLNALIGWLHFQDNQMY*LCFLLRKWRGLKTC KLPLSTFASIPSTPVRAIWGEESLPRFFWKGTN LNFFPLLCLRVILFRVAPLLIFSRICYLPEASVL VVSTKF*DLWRCFLMWEGRC*CMQGLN*IDPAL VEGGTITLEART*SRSCCPQKCFLFHHFCF*GS FSVARSSQGF*YLHWS*GLL**WWPSCAQRTARQ ALGGSLERQSW*MGFKWSQRGWL*GDPRHCRTM CTLCVLDVLGMWEPRNNPVDGIGAAAAGDLCAL PSFSRTV*VRSHLWMRPSQPRRSRPSSETKKRAG SLGLVLNFPFNVAKHS*LTRALESTACWPGFKM KSVLMLP*KGGGGEEGKIKASFQVLI*FNCQKI DRP*ITSPSH*GLKACNPPLAVSPATEVSDLPYN QVGPPVLQSGGASAGSTHPPHLPRPELPLPFVT T*GHEHRPWGVPGESACGSGLACGLLCAAARMG CAGEAWGSAGGWLGYTGYLCSHCLFANALWTFVC *ILLNKKDGLKPRCCIFICNYV*SEAVLNCKDF FQCVFSNFATTYWLRILFIFLSSYQLQTLVKSP SALSKNNKFPVKFW

Frame 2

S*SGGNRGVNHFTMCG*VLQLR*PPVHRGRAVS GDRAERRPWVGISQSSLCQPPYFDHFAAEQQRR STSASLSNLSAPSRSLTIGLMQRDGQFCRAIPA RSSCSACTHGRTRRRYRLPACPAHPPERLSAHAR TGAVCRASAEPEQPR*SACALPRLPCPLLASVA AALAASGGAAAYCLSPRRR*RVVPARPAGEPRE PHVSWVMKLNPQQAPLYGDCVVTVLLAEEDKAED DVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPG HDCCETVKVQLCASKEGLPVFVVAEEDFHFVQD EAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGD VNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDA GPRETLMHFAVRLGLLRLTWFLLQKPGGRGALS IHNQEGATPVSLALERGYHKLHQLLTEENAGEPD SWSSLSYEIPYGDCSVRHHRELDIYTLTSESDS HHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQM DSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQ RLSSSEETESTQCCPGSPVAQTESPCDLSSIVE EENTDRSCRKKNKGVERKGEEVEPAPIVDSGTV SDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTK SSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSS GGELGGISTTNVSTPDTAGEMEHGLMNPDATVW KNVLQGGESTKERFENSNIGTAGASDVHVTSKPV DKISVPNCAPAASSLDGNKPAESSLAFSNEETS TEKTAETETSRSREESADAPVDQNSVVIPAAAK DKISDGLEPYTLLAAGIGEAMSPSDLALLGLEED VMPHQNSETNSSHAQSQKGKSSPICSTTGDDKL CADSACQQNTVTSSGDLVAKLCDNIVSESESTT ARQPSSQDPPDASHCEDPQAHTVTSDPVRDTQER ADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSH PHPVVPKMEKELVPDQAVISDSTFSLANSPGSE SVTKDDALSFVPSQKEKGTATPELHTATDYRDGP DGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMG NTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSL QSVGKATLALDSVLTEEGKLLVVSESSAAQEQDK DKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQ QFHEKSISADCAKDKALQLSNSPGASSAFLKAE TEHNKEVAPQVSLLTQGGAAQSLVPPGASLATES RQEALGAEHNSSALLPCLLPDGSDGSDALNCSQ PSPLDVGVKNTQSQGKTSACEVSGDVTVDVTGV NALQGMAEPRRENISHNTQDILIPNVLLSQEKNA VLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGK LEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKE LPTDMELSAHDDGAPAGVREVMRAPPSGRERSTP SLPCMVSAQDAPLPKGADLIEEAASRIVDAVIE QVKAAGALLTEGEACHMSLSSPELGPLTKGLES AFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAG REEPEKIILPVQGPEPAAEMPDVKAEDEVDFRA SSISEEVAVGSIAATLKMKQGPMTQAINRENWC TIEPCPDAASLLASKQSPECENFLDVGLGRECTS KQGVLKRESGSDSDLFHSPSDDMDSIIFPKPEE EHLACDITGSSSSTDDTASLDRHSSHGSDVSLS QILKPNRSRDRQSLDGFYSHGMGAEGRESESEPA DPGDVEEEEMDSITEVPANCSVLRSSMRSLSPF RRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRP PIHRRSFSLEGLTGGAGVGNKPSSSLEVSSANAE ELRHPFSGEERVDSLVSLSEEDLESDQREHRMF DQQICHRSKQQGFNYCTSAISSPLTKSISLMTI SHPGLDNSRPFHSTFHNTSANLTESITEENYNFL PHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKK SKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTF SSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVH KGCRESLASCAKVKMKQPKGSLQAHDTSSLPTV IMRNKPSQPKERPRSAVLLVDETATTPIFANRR SQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH STDSLNKISKVNESTESLTDEGVGTDMNEGQLL GDFEIESKQLEAESWSRIIDSKFLKQQKKDVVK RQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADL LFEQQMVEKLFPCLDELISIHSQFFQRILERKK ESLVDKSEKNFLIKRIGDVLVNQFSGENAERLK KTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKK MSSSVVRRLGIPECILLVTQRITKYPVLFQRIL QCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVAS YEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLK RKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVF LQEKDQKYIFASLDQKSTVISLKKLIVREVAHE EKGLFLISMGMTDPEMVEVHASSKEERNSWIQII QDTINTLNRDEDEGIPSENEEEKKMLDTRAREL KEQLHQKDQKILLLLEEKEMIFRDMAECSTPLP EDCSPTHSPRVLFRSNTEEALKGGPLMKSAINEV EILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSL PRRAETFGGFDSHQMNASKGGEKEEGDDGQDLR RTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHL YELLSALQGVVLQQDSYIEDQKLVLSERALTRS LSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQY LEEKRRREREWEARERELREREALLAQREEEVQQ GQQDLEKEREELQQKKGTYQYDLERLRAAQKQL EREQEQLRREAERLSQRQTERDLCQVSHPHTKL MRIPSFFPSPEEPPSPSAPSIAKSGSLDSELSVS PKRNSISRTHKDKGPFHILSSTSQTNKGPEGQS QAPASTSASTRLFGLTKPKEKKEKKKKNKTSRS QPGDGPASEVSAEGEEIFC*PSSSLLRQLPPDPG QPTSPAVPACTSLLHWTPTAPQRPVLLGGPRSW TISNR*Y*VSGGEGGPDSASAMICDCPGLSGWA GPTQDYTESNGLVSTGDGFGHVRNS*RLKECIQV RSEPPNAFYLGEHKTKQQMFWT*SVYVHGDLSA YTHGECQKKAQSAPGVWST*HKGSAWTDPEPPH ISSSPSTPQRLVSL*THPGHIPPVFCMYFSFHFR DDKHL*NQ*EKA*CV*KT*CAPPRSRCFRH*SN KTTHSISFCHQIQKKYPGFPACLPTCFGHG*SE EAYSPLSLQRDTF*LSLTTQKGPRPPGCVPEPPS CLSQTAAVWPLLGEGTPLPGVSLAPRPGRSCAL KLGQLAEKWVQAKGEAMCSSSCQCRSGEELARK AWL*KRPSYVRRPWQNWISSKIHVKVCC*IVLCP WKQIQMAACCSALLLLFPPCFHLCSLEAFPSWC VQDSSW*CCPLRPRTPEGRPWKILCFQRGLQFL LFCPSEAWGF*AHLKKEKSVTWCLLMNCKLALQM EIFIFQFI*KRSGLKFVAYICFIYCICVFVFVF F*G*ARSSPTV*TIQSIPSEVAASTVHSVSFEV P*RPR*NFKGRGSMSFPPPPRLIL*SKDVFSLV* E*RNSPPLTYLCLFLSWRILTLQKQTKGQNLLI FLLKICPLAKTLNKKLSFFLSPICTTPSYS*IC RDFPEIYPGLGCLFWALAPSSPPGICRRAVLNLH SSPCKCRPGAPVLRVWNNTRLVLMGFTCVRALH KNTVDAEVRARRHRA*HQC*RVSYSPPSCDVSS ALVVLVVFFKNRDFTSAQTPLKTIWSGSGWTSLK SK*CPEFPQTTQLHPGIQSAVQQQNRLPRTVLT YLCHLSSPLGSCPQGDLFLSWGFTWDGGCLCFC SWP*QCSSCWI*WPVLVSIT*EGVVFLG*LGLNS PYCFHAGTPCSPSS*RNHVPETVLKFWGKDGVP IQSPQISRIE*ASWKETASSLNSSHLSRCR*VT CAL*MLSSVGFIFKTIKCIDCVFFLENGEG*KHA NCHFQPLPVFPLPP*ELSGGKNPYQGFFGKVRI LTFFPFCVSG*YYSESPLCSFSPVFVTFLRPQY *S*AQSFETFGVVS*CGRGGVSACKG*TR*TLP* *RVGL*P*RPELDPEVAVHRSAFYFIIFVSRAL FL*PGLPKDFSICIGVEVYSNDGGPAVPRGQPG RPWEGV*KDSPGEWASSGHKEGGCEVTPDTAERC APSAFWMSLECGSLEITLWMELGQRLLEICVPC LPSAGPSRCAATYGCVPASPVALVHPQRQRRGQ GVWAWF*TFLSM*QSIPS*PEPWNLLPAGQALK* KVF*CCHKREAGGRKGK*RHLSKYSSNLIVKRL IGHELLLHLTKG*RRATPHWLCPLPPK*VTCPT TRWDHLCCSPEGLLQEALTPHTFPGLSFPYLSSP PEGMSTGHGACLVSLPVVQA*PVVSCVLLPAWD AQGRRGDPQEGGWDTPDTSALIACLQMLYGHLC AKSY*IKKTG*NPDAVYSFVIMYKVKQF*TVKIF FSVFSRILPQHTGFVFYLSFFLVTSFRPL*SLP QPFQKIINFL*SS