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Sequence AKAP13.aAug05
TGAGTTGAAGTGGGGGAAATAGAGGAGTAAATCATTTCACGATGTGTGGTTAAGTGCTGCAGCTCAGGTAACCACCAGTACACAGAGGAAGGGCGGTTTCTGGAGACAGGGCGGAGAGGAGACCGTGGGTGGGCATTTCCCAGAGCAGCCTCTGCCAGCCACCCTACTTTGATCACTTTGCCGCCGAGCAGCAGCGGCGG
TCAACCTCAGCCTCCCTTAGCAACCTGAGTGCCCCGTCCAGGAGCCTTACTATTGGTCTCATGCAGCGAGATGGGCAGTTCTGCCGTGCAATCCCAGCTC
GCAGTTCTTGCTCCGCGTGTACTCACGGGAGGACTCGCAGGCGTTACCGCCTTCCCGCGTGCCCCGCCCACCCTCCCGAGCGTCTTTCGGCGCATGCGCG
GACTGGAGCTGTGTGCAGGGCCAGCGCGGAGCCCGAGCAGCCGCGGTGAAGCGCCTGTGCTCTGCCGAGACTGCCGTGCCCATTGCTCGCCTCGGTCGCC
GCCGCTTTAGCCGCCTCCGGGGGAGCGGCCGCCTATTGTCTTTCTCCGCGGCGAAGGTGAAGAGTTGTCCCAGCTCGGCCCGCGGGGGAGCCCCGGGAGC
CGCACGTGTCCTGGGTCATGAAACTTAATCCACAGCAAGCTCCCTTATATGGTGATTGTGTTGTTACAGTGCTGCTTGCTGAAGAGGACAAAGCTGAAGA
TGATGTAGTGTTTTACTTGGTATTTTTGGGTTCCACCCTCCGTCACTGTACAAGTACTCGGAAGGTCAGTTCTGATACATTGGAGACCATTGCTCCTGGT
CATGATTGTTGTGAAACAGTGAAGGTGCAGCTCTGTGCTTCCAAAGAGGGCCTTCCCGTGTTTGTGGTGGCTGAAGAAGACTTTCATTTCGTCCAGGATG
AAGCGTATGATGCAGCTCAATTCCTAGCAACCAGTGCTGGAAATCAGCAGGCTTTGAACTTTACCCGTTTTCTTGACCAGTCAGGACCCCCATCTGGGGA
TGTGAATTCCCTTGATAAGAAGTTGGTGCTGGCATTCAGGCACCTGAAGCTGCCCACGGAGTGGAATGTATTGGGGACAGATCAGAGTTTGCATGATGCT
GGCCCGCGAGAGACATTGATGCATTTTGCTGTGCGGCTGGGACTGCTGAGGTTGACGTGGTTCCTGTTGCAGAAGCCAGGTGGCCGCGGAGCTCTCAGTA
TCCACAACCAGGAAGGGGCGACGCCTGTGAGCTTGGCCTTGGAGCGAGGCTATCACAAGCTGCACCAGCTTCTAACCGAGGAGAATGCTGGAGAACCAGA
CTCCTGGAGCAGTTTATCCTATGAAATACCGTATGGAGACTGTTCTGTGAGGCATCATCGAGAGTTGGACATCTATACATTAACCTCTGAGTCTGATTCA
CATCATGAACACCCATTTCCTGGAGACGGTTGCACTGGACCAATTTTTAAACTTATGAACATCCAACAGCAACTAATGAAAACAAACCTCAAGCAGATGG
ACAGTCTTATGCCCTTAATGATGACAGCACAGGATCCTTCCAGTGCCCCAGAGACAGATGGCCAGTTTCTTCCCTGTGCACCGGAGCCCACGGACCCTCA
GCGACTTTCTTCTTCTGAAGAGACTGAGAGCACTCAGTGCTGCCCAGGGAGCCCTGTTGCACAGACTGAAAGTCCCTGTGATTTGTCAAGCATAGTTGAG
GAGGAGAATACAGACCGTTCCTGTAGGAAGAAAAATAAAGGCGTGGAAAGAAAAGGGGAAGAGGTGGAGCCAGCACCTATTGTGGACTCTGGAACTGTAT
CTGATCAAGACAGCTGCCTTCAGAGCTTGCCTGATTGTGGAGTAAAGGGCACGGAAGGCCTTTCGTCCTGTGGAAACAGAAATGAAGAAACTGGAACAAA
ATCTTCTGGAATGCCCACAGACCAGGAGTCCCTGAGCAGTGGAGATGCTGTGCTTCAGAGAGACTTGGTCATGGAGCCAGGCACAGCCCAGTATTCCTCT
GGAGGTGAACTGGGAGGCATTTCAACAACAAATGTCAGTACCCCAGACACTGCAGGGGAAATGGAACATGGGCTCATGAACCCAGATGCCACTGTTTGGA
AGAATGTGCTTCAGGGAGGGGAAAGTACAAAGGAAAGATTTGAGAACTCTAATATTGGCACAGCTGGAGCCTCTGACGTGCACGTCACAAGTAAGCCTGT
GGATAAAATCAGTGTTCCAAACTGTGCCCCTGCTGCCAGTTCCCTGGATGGTAACAAACCTGCTGAGTCTTCACTTGCATTTAGTAATGAAGAAACCTCC
ACTGAAAAAACAGCAGAAACGGAAACTTCACGAAGTCGTGAGGAGAGTGCTGATGCTCCAGTAGATCAGAATTCTGTGGTGATTCCAGCTGCTGCAAAAG
ACAAGATTTCAGATGGATTAGAACCTTATACTCTCTTAGCAGCAGGCATAGGTGAGGCAATGTCACCCTCAGATTTAGCCCTTCTTGGGCTGGAAGAAGA
TGTAATGCCACACCAGAACTCAGAAACAAATTCATCTCATGCTCAAAGCCAAAAGGGCAAATCCTCACCCATTTGTTCTACAACTGGAGACGATAAACTT
TGTGCAGACTCTGCATGTCAACAGAACACAGTGACTTCTAGTGGCGATTTGGTTGCAAAACTGTGTGATAACATAGTTAGCGAGTCCGAAAGCACCACAG
CAAGGCAACCCAGCTCACAAGATCCACCCGATGCCTCCCACTGTGAAGACCCACAGGCTCATACAGTCACCTCTGACCCTGTAAGGGATACCCAGGAACG
TGCGGATTTTTGTCCTTTCAAAGTGGTGGATAACAAAGGCCAACGAAAAGATGTGAAACTAGATAAACCTTTAACAAATATGCTTGAGGTGGTTTCACAT
CCACATCCAGTTGTCCCTAAAATGGAGAAAGAACTGGTGCCAGACCAGGCAGTAATATCAGACAGTACTTTCTCTCTGGCAAACAGTCCAGGCAGTGAAT
CAGTAACCAAGGATGACGCACTTTCTTTTGTCCCCTCCCAGAAAGAAAAGGGAACAGCAACTCCTGAACTACATACAGCTACAGATTATAGAGATGGCCC
AGATGGAAATTCGAATGAGCCTGATACGCGGCCACTAGAAGACAGGGCAGTAGGCCTGTCCACATCCTCCACTGCTGCAGAGCTTCAGCACGGGATGGGG
AATACCAGTCTCACAGGACTTGGTGGAGAGCATGAGGGTCCCGCCCCTCCAGCAATCCCAGAAGCTCTGAATATCAAGGGGAACACTGACTCTTCCCTGC
AAAGTGTGGGTAAGGCCACTTTGGCTTTAGATTCAGTTTTGACTGAAGAAGGAAAACTTCTGGTGGTTTCAGAAAGCTCTGCAGCTCAGGAACAAGATAA
GGATAAAGCGGTGACCTGTTCCTCTATTAAGGAAAATGCTCTCTCTTCAGGAACTTTGCAGGAAGAGCAGAGAACACCACCTCCTGGACAAGATACTCAA
CAATTTCATGAAAAATCAATCTCAGCTGACTGTGCCAAGGACAAAGCACTTCAGCTAAGTAATTCACCGGGTGCATCCTCTGCCTTTCTTAAGGCAGAAA
CTGAACATAACAAGGAAGTGGCCCCACAAGTCTCACTGCTGACTCAAGGTGGGGCTGCCCAGAGCCTGGTGCCACCAGGAGCAAGTCTGGCCACAGAGTC
AAGGCAGGAAGCCTTGGGGGCAGAGCACAACAGCTCCGCTCTGTTGCCATGTCTGTTGCCAGATGGGTCTGATGGGTCCGATGCTCTTAACTGCAGTCAG
CCTTCTCCTCTGGATGTTGGAGTGAAGAACACTCAATCCCAGGGAAAAACTAGTGCCTGTGAGGTGAGTGGAGATGTGACGGTGGATGTTACAGGGGTTA
ATGCTCTACAAGGTATGGCTGAGCCCAGAAGAGAGAATATATCACACAACACCCAAGACATCCTGATTCCAAACGTCTTGTTGAGCCAAGAGAAGAATGC
CGTTCTAGGTTTGCCAGTGGCTCTACAGGACAAAGCTGTGACTGACCCACAGGGAGTTGGAACCCCAGAGATGATACCTCTTGATTGGGAGAAAGGGAAG
CTGGAGGGAGCAGACCACAGCTGTACCATGGGTGACGCTGAGGAAGCCCAAATAGACGATGAAGCACATCCTGTCCTACTGCAGCCTGTTGCCAAGGAGC
TCCCCACAGACATGGAGCTCTCAGCCCATGATGATGGGGCCCCAGCTGGTGTGAGGGAAGTCATGCGAGCCCCGCCTTCAGGCAGGGAAAGGAGCACTCC
CTCTCTACCTTGCATGGTCTCTGCCCAGGACGCACCTCTGCCTAAGGGGGCAGACTTGATAGAGGAGGCTGCCAGCCGTATAGTGGATGCTGTCATCGAA
CAAGTCAAGGCCGCTGGAGCACTGCTTACTGAGGGGGAGGCCTGTCACATGTCACTGTCCAGCCCTGAGTTGGGTCCTCTCACTAAAGGACTAGAGAGTG
CTTTTACAGAAAAAGTGAGTACTTTCCCACCTGGGGAGAGCCTACCAATGGGCAGTACTCCTGAGGAAGCCACGGGGAGCCTTGCAGGATGTTTTGCTGG
AAGGGAGGAGCCAGAGAAGATCATTTTACCTGTCCAGGGGCCTGAGCCAGCAGCAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCA
AGTTCAATTTCTGAAGAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTA
CAATAGAGCCATGCCCTGATGCAGCATCTCTTCTGGCTTCCAAGCAGAGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTC
AAAACAAGGTGTACTTAAAAGAGAATCTGGGAGTGATTCTGACCTCTTTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAA
GAGCATTTGGCCTGTGATATCACCGGATCCAGTTCATCCACCGATGACACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCC
AGATTTTAAAGCCAAACAGGTCAAGAGATCGGCAAAGCCTTGATGGATTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGC
TGACCCAGGCGACGTGGAGGAGGAGGAGATGGACAGTATCACTGAAGTGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTC
CGGAGGCACAGCTGGGGGCCTGGGAAAAATGCAGCCAGCGATGCAGAAATGAACCACCGGAGTATGAGCTGGTGCCCCTCTGGTGTGCAGTACTCTGCTG
GCCTGAGTGCTGACTTTAATTACAGAAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGGTGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTC
TGCAAATGCCGAAGAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTGTCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAA
CATAGGATGTTTGATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTACATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCAT
TAATGACAATCAGCCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAATACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAA
CTATAATTTCCTGCCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAAGTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCT
AGCAGCAAGAAGAGCAAAGAAAAGGAAAAAGAAAAAGATAAGATTAAGGAGAAGGAGAAAGATTCTAAAGACAAGGAGAAAGATAAGAAGACTGTCAACG
GGCACACTTTCAGTTCCATTCCTGTTGTGGGTCCCATCAGCTGTAGCCAGTGTATGAAGCCCTTCACCAACAAAGATGCCTATACTTGTGCAAATTGCAG
TGCTTTTGTCCACAAAGGCTGCCGAGAAAGTCTAGCCTCCTGTGCAAAGGTCAAAATGAAGCAGCCCAAAGGGAGCCTTCAGGCACATGACACATCATCA
CTGCCCACGGTCATTATGAGAAACAAGCCCTCACAGCCCAAGGAGCGTCCTCGGTCCGCAGTCCTCCTGGTGGATGAAACCGCTACCACCCCAATATTTG
CCAATAGACGATCCCAGCAGAGTGTCTCGCTCTCCAAAAGTGTCTCCATACAGAACATTACTGGAGTTGGCAATGATGAGAACATGTCAAACACCTGGAA
ATTCCTGTCTCATTCAACAGACTCACTAAATAAAATCAGCAAGGTCAATGAGTCAACAGAATCACTTACTGATGAGGGAGTAGGTACAGACATGAATGAA
GGACAACTACTGGGAGACTTTGAGATTGAGTCCAAACAGCTGGAAGCAGAGTCTTGGAGTCGGATAATAGACAGCAAGTTTCTAAAACAGCAAAAGAAAG
ATGTGGTCAAACGGCAAGAAGTAATATATGAGTTGATGCAGACAGAGTTTCATCATGTCCGCACTCTCAAGATCATGAGTGGTGTGTACAGCCAGGGGAT
GATGGCGGATCTGCTTTTTGAGCAGCAGATGGTAGAAAAGCTGTTCCCCTGTTTGGATGAGCTGATCAGTATCCATAGCCAATTCTTCCAGAGGATTCTG
GAGCGGAAGAAGGAGTCTCTGGTGGATAAAAGTGAAAAGAACTTTCTCATCAAGAGGATAGGGGATGTGCTTGTAAATCAGTTTTCAGGTGAGAATGCAG
AACGTTTAAAGAAGACATATGGCAAGTTTTGTGGGCAACATAACCAGTCTGTAAACTACTTCAAAGACCTTTATGCCAAGGATAAGCGTTTTCAAGCCTT
TGTAAAGAAGAAGATGAGCAGTTCAGTTGTTAGAAGGCTTGGAATTCCAGAGTGCATATTGCTTGTAACTCAGCGGATTACCAAGTACCCAGTTTTATTC
CAAAGAATATTGCAGTGTACCAAAGACAATGAAGTGGAGCAGGAAGATCTAGCACAGTCCTTGAGCCTGGTGAAGGATGTGATTGGAGCTGTAGACAGCA
AAGTGGCAAGTTATGAAAAGAAAGTGCGTCTCAATGAGATTTATACAAAGACAGATAGCAAGTCAATCATGAGGATGAAGAGTGGTCAGATGTTTGCCAA
GGAAGATTTGAAACGGAAGAAGCTTGTACGTGATGGGAGTGTGTTTCTGAAGAATGCAGCAGGAAGGTTGAAAGAGGTTCAAGCAGTTCTTCTCACTGAC
ATTTTAGTTTTCCTTCAAGAAAAAGACCAGAAGTACATCTTTGCATCATTGGACCAGAAGTCAACAGTGATCTCTTTAAAGAAGCTGATTGTGAGAGAAG
TGGCACATGAGGAGAAAGGTTTATTCCTGATCAGCATGGGGATGACAGATCCAGAGATGGTAGAAGTCCATGCCAGCTCCAAAGAGGAACGAAACAGCTG
GATTCAGATCATTCAGGACACAATCAACACCCTGAACAGAGATGAAGATGAAGGAATTCCTAGTGAGAATGAGGAAGAAAAGAAAATGTTGGACACCAGA
GCCCGAGAATTAAAAGAACAACTTCACCAGAAGGACCAAAAAATCCTACTCTTGTTGGAAGAGAAGGAGATGATTTTCCGGGACATGGCTGAGTGCAGCA
CCCCTCTCCCAGAGGATTGCTCCCCAACACATAGCCCTAGAGTTCTCTTCCGCTCCAACACAGAAGAGGCTCTCAAAGGAGGACCTTTAATGAAAAGTGC
AATAAATGAGGTGGAGATCCTTCAGGGTTTGGTGAGTGGAAATCTGGGAGGCACACTTGGGCCGACTGTCAGCAGCCCCATTGAGCAAGATGTGGTCGGT
CCCGTTTCCCTGCCCCGGAGAGCAGAGACCTTTGGAGGATTTGACAGCCATCAGATGAATGCTTCAAAAGGAGGCGAGAAGGAAGAGGGAGATGATGGCC
AAGATCTTAGGAGAACGGAATCAGATAGTGGCCTAAAAAAGGGTGGAAATGCTAACCTGGTATTTATGCTTAAAAGAAACAGTGAGCAGGTTGTCCAGAG
CGTTGTTCATCTCTACGAGCTCCTCAGCGCTCTGCAGGGTGTGGTGCTGCAGCAGGACAGCTACATTGAGGACCAGAAACTGGTGCTGAGCGAGAGGGCG
CTCACTCGCAGCTTGTCCCGCCCGAGCTCCCTCATTGAGCAGGAGAAGCAGCGCAGCCTGGAGAAGCAGCGCCAGGACCTGGCCAACCTGCAGAAGCAGC
AGGCCCAGTACCTCGAGGAGAAGCGCAGGCGCGAGCGTGAGTGGGAAGCTCGTGAGAGGGAGCTGCGGGAGCGGGAGGCCCTCCTGGCCCAGCGCGAGGA
GGAGGTGCAGCAGGGGCAGCAGGACCTGGAAAAGGAGCGGGAGGAGCTCCAGCAGAAGAAGGGCACATACCAGTATGACCTGGAGCGACTGCGTGCTGCC
CAGAAACAGCTTGAGAGGGAACAGGAGCAGCTGCGCCGGGAGGCAGAGCGGCTCAGCCAGCGGCAGACAGAACGGGACCTGTGTCAGGTTTCCCATCCAC
ATACCAAGCTGATGAGGATCCCATCGTTCTTCCCCAGTCCTGAGGAGCCCCCCTCGCCATCTGCACCTTCCATAGCCAAATCAGGGTCATTGGACTCAGA
ACTTTCAGTGTCCCCAAAAAGGAACAGCATCTCTCGGACACACAAAGATAAGGGGCCTTTTCACATACTGAGTTCAACCAGCCAGACAAACAAAGGACCA
GAAGGGCAGAGCCAGGCCCCTGCGTCCACCTCTGCCTCTACCCGCCTGTTTGGGTTAACAAAGCCAAAGGAAAAGAAGGAGAAAAAAAAGAAGAACAAAA
CCAGCCGCTCTCAGCCCGGTGATGGTCCCGCGTCAGAAGTATCAGCAGAGGGTGAAGAGATCTTCTGCTGACCCTCTTCCTCTCTGCTGAGGCAGCTGCC
TCCTGATCCTGGCCAGCCCACCTCTCCTGCTGTCCCCGCGTGCACAAGTCTCTTACACTGGACGCCCACTGCTCCTCAGCGTCCAGTCCTCCTGGGCGGC
CCCAGGTCCTGGACAATAAGCAACAGATGATATTGAGTGTCGGGTGGGGAAGGAGGCCCAGACTCTGCTTCGGCCATGATTTGTGACTGCCCAGGACTCT
CAGGTTGGGCTGGCCCTACTCAGGATTACACTGAAAGTAATGGCCTCGTAAGTACAGGTGATGGTTTTGGACACGTCAGGAATTCCTAAAGGCTGAAAGA
GTGTATCCAAGTAAGGTCTGAACCTCCGAATGCCTTTTATTTGGGGGAACACAAAACCAAACAGCAGATGTTTTGGACTTGATCTGTGTACGTACATGGG
GACCTGTCTGCATATACACACGGGGAATGCCAGAAGAAGGCCCAGTCTGCACCAGGCGTCTGGTCAACTTAGCACAAGGGCAGTGCCTGGACGGACCCGG
AGCCCCCGCATATCAGCAGTTCACCCAGTACTCCTCAGAGACTGGTTTCCCTCTAAACCCATCCCGGGCACATACCACCCGTGTTTTGCATGTATTTCTC
ATTTCATTTTAGGGATGACAAACATTTGTGAAACCAGTGAGAGAAGGCTTGATGTGTATAAAAGACGTGATGTGCACCACCTCGATCTCGGTGTTTCAGG
CACTAAAGCAACAAAACAACCCATAGTATCTCATTCTGTCATCAGATCCAGAAGAAATATCCTGGTTTTCCAGCATGTTTACCCACATGTTTTGGCCATG
GATAAAGTGAAGAGGCCTACTCACCATTATCCCTGCAGCGTGACACCTTTTGATTGTCACTGACCACTCAGAAGGGGCCACGGCCTCCTGGCTGTGTTCC
TGAGCCCCCGTCGTGCCTCTCCCAGACAGCAGCTGTCTGGCCCTTGCTGGGTGAGGGCACACCACTGCCAGGGGTCAGCCTCGCACCCAGGCCAGGCAGA
AGCTGTGCTCTGAAGCTAGGACAGCTGGCTGAGAAGTGGGTTCAGGCGAAGGGTGAAGCCATGTGTAGCAGTTCCTGCCAGTGCAGATCTGGAGAGGAGC
TGGCCCGGAAGGCGTGGTTGTGAAAGCGCCCTTCTTATGTTAGGAGGCCTTGGCAAAATTGGATTTCTTCAAAAATACATGTAAAGGTCTGTTGTTGAAT
TGTACTCTGCCCCTGGAAGCAGATACAGATGGCTGCCTGCTGCTCGGCTTTGCTTTTGCTTTTCCCACCGTGTTTTCATCTTTGTTCACTTGAGGCTTTC
CCCAGCTGGTGTGTGCAGGACAGTTCATGGTAATGTTGCCCTCTGAGGCCCCGTACACCAGAAGGGAGGCCCTGGAAAATTTTGTGCTTCCAACGTGGCC
TTCAATTCTTGCTTTTTTGCCCCTCGGAAGCATGGGGCTTTTGAGCACACTTAAAAAAAGAAAAATCTGTAACTTGGTGCTTATTGATGAATTGCAAGCT
GGCCTTGCAGATGGAGATATTTATCTTTCAGTTTATTTGAAAGAGGTCTGGTTTAAAATTTGTAGCCTACATTTGTTTTATTTATTGTATTTGTGTGTTT
GTGTTTGTTTTTTTTTAAGGGTGAGCCAGGTCTAGCCCAACAGTCTAAACTATCCAGTCAATACCGAGTGAAGTGGCAGCCAGCACTGTTCACTCTGTGT
CTTTTGAAGTGCCTTGAAGGCCCAGATGAAATTTTAAAGGGAGGGGGTCCATGTCCTTCCCTCCCCCACCCCGCCTCATTCTTTAATCAAAGGATGTCTT
CTCCCTTGTTTGAGAATGAAGAAACTCGCCACCTCTGACCTACCTTTGCCTTTTTCTGTCATGGAGAATACTCACCCTTCAGAAACAGACCAAAGGCCAA
AACCTGCTGATTTTTCTATTGAAAATATGTCCCCTTGCAAAGACCCTAAACAAAAAGTTAAGTTTCTTTCTTTCACCTATTTGTACAACTCCAAGTTACA
GCTGAATCTGTCGTGACTTTCCTGAGATCTACCCGGGGCTTGGCTGTCTGTTCTGGGCACTGGCTCCGAGTTCCCCTCCTGGGATTTGCAGGAGGGCAGT
ACTGAACCTGCATTCTTCTCCTTGTAAATGTAGGCCGGGTGCCCCTGTTCTCCGGGTTTGGAACAATACGAGGTTGGTGCTGATGGGATTTACTTGCGTA
CGTGCTCTTCACAAAAACACCGTGGATGCTGAAGTTAGAGCACGTCGCCACAGAGCTTGACATCAATGTTAGAGGGTCTCTTACTCCCCGCCCAGCTGTG
ATGTTTCATCTGCTTTGGTTGTTTTGGTGGTCTTTTTTAAAAATAGAGATTTCACATCTGCCCAGACCCCACTCAAAACGATTTGGTCAGGTTCTGGTTG
GACAAGTTTAAAATCAAAGTAGTGCCCGGAATTCCCTCAAACCACCCAACTTCATCCAGGAATACAGTCTGCAGTGCAGCAACAGAACCGCTTACCAAGA
ACTGTGCTTACATACCTTTGTCATCTCTCTTCCCCCCTTGGAAGTTGTCCTCAGGGGGATTTGTTCCTGTCCTGGGGATTTACCTGGGATGGTGGCTGCC
TGTGCTTTTGCTCATGGCCTTGACAGTGCTCTAGTTGCTGGATCTAATGGCCTGTCTTGGTTTCTATCACATGAGAAGGGGTTGTTTTTTTGGGGTGACT
CGGACTGAATTCCCCATACTGTTTCCACGCCGGGACACCATGTTCTCCATCAAGCTAAAGAAATCACGTGCCTGAAACTGTGCTTAAGTTTTGGGGGAAA
GATGGAGTTCCTATCCAGAGCCCCCAGATTTCCAGAATCGAGTGAGCTTCCTGGAAGGAGACTGCGTCTTCTCTCAATTCCAGTCATCTCAGTCGTTGTC
GTTAGGTGACATGTGCACTTTAAATGCTCTCATCGGTTGGCTTCATTTTCAAGACAATCAAATGTATTGACTGTGTTTTCTTCTTAGAAAATGGAGAGGG
TTAAAAACATGCAAACTGCCACTTTCAACCTTTGCCAGTATTCCCTCTACCCCCGTGAGAGCTATCTGGGGGGAAGAATCCTTACCAAGGTTTTTTTGGA
AAGGTACGAATCTTAACTTTTTTCCCCTTCTGTGTCTCAGGGTAATACTATTCAGAGTCGCCCCTTTGCTCATTTTCTCCCGTATTTGTTACCTTCCTGA
GGCCTCAGTATTAGTCGTGAGCACAAAGTTTTGAGACCTTTGGCGTTGTTTCTTGATGTGGGAGGGGAGGTGTTAGTGCATGCAAGGGTTGAACTAGATA
GACCCTGCCTTAGTAGAGGGTGGGACTATAACCTTAGAGGCCAGAACTTGATCCAGAAGTTGCTGTCCACAGAAGTGCTTTCTATTTCATCATTTTTGTT
TCTAGGGCTCTTTTTCTGTAGCCAGGTCTTCCCAAGGATTTTAGTATTTGCATTGGAGTTGAGGTTTACTCTAATGATGGTGGCCCAGCTGTGCCCAGAG
GACAGCCAGGCAGGCCCTGGGAGGGAGTTTAGAAAGACAGTCCTGGTGAATGGGCTTCAAGTGGTCACAAAGAGGGTGGCTGTGAGGTGACCCCAGACAC
TGCAGAACGATGTGCACCCTCTGCGTTTTGGATGTCCTTGGAATGTGGGAGCCTAGAAATAACCCTGTGGATGGAATTGGGGCAGCGGCTGCTGGAGATC
TGTGTGCCTTGCCTTCCTTCAGCAGGACCGTCTAGGTGCGCAGCCACCTATGGATGCGTCCCAGCCAGCCCCGTCGCTCTCGTCCATCCTCAGAGACAAA
GAAGAGGGCAGGGAGTTTGGGCTTGGTTTTGAACTTTCCTTTCAATGTAGCAAAGCATTCCTAGTTAACCAGAGCCTTGGAATCTACTGCCTGCTGGCCA
GGCTTTAAAATGAAAAGTGTTTTAATGCTGCCATAAAAGGGAGGCGGGGGGGAGGAAGGGAAAATAAAGGCATCTTTCCAAGTACTCATCTAATTTAATT
GTCAAAAGATTGATAGGCCATGAATTACTTCTCCATCTCACTAAGGGTTAAAGGCGTGCAACCCCCCACTGGCTGTGTCCCCTGCCACCGAAGTGAGTGA
CCTGCCCTACAACCAGGTGGGACCACCTGTGCTGCAGTCCGGAGGGGCTTCTGCAGGAAGCACTCACCCCCCACACCTTCCCCGGCCTGAGCTTCCCCTA
CCTTTCGTCACCACCTGAGGGCATGAGCACAGGCCATGGGGCGTGCCTGGTGAGTCTGCCTGTGGTTCAGGCTTAGCCTGTGGTCTCCTGTGTGCTGCTG
CCCGCATGGGATGCGCAGGGGAGGCGTGGGGATCCGCAGGAGGGTGGTTGGGATACACCGGATACCTCTGCTCTCATTGCTTGTTTGCAAATGCTCTATG
GACATTTGTGTGCTAAATCCTATTAAATAAAAAAGACGGGTTAAAACCCAGATGCTGTATATTCATTTGTAATTATGTATAAAGTGAAGCAGTTTTAAAC
TGTAAAGATTTTTTTCAGTGTGTTTTCTCGAATTTTGCCACAACATACTGGCTTCGTATTTTATTTATCTTTCTTTCTAGTTACCAGCTTCAGACCCTTG
TAAAGTCTCCCTCAGCCCTTTCAAAAAATAATAAATTTCCTGTGAAGTTCTGG
- AKAP13-F1 (forward primer)
- AKAP13-R1 (reverse primer)
- Single exon skipping
Frame 0
*VEVGEIEE*IISRCVVKCCSSGNHQYTEEGRFLETGRRGDRGWAFPRAASASHPTLITLPPSSSGG
QPQPPLAT*VPRPGALLLVSCSEMGSSAVQSQL
AVLAPRVLTGGLAGVTAFPRAPPTLPSVFRRMR
GLELCAGPARSPSSRGEAPVLCRDCRAHCSPRSP
PL*PPPGERPPIVFLRGEGEELSQLGPRGSPGS
RTCPGS*NLIHSKLPYMVIVLLQCCLLKRTKLK
MM*CFTWYFWVPPSVTVQVLGRSVLIHWRPLLLV
MIVVKQ*RCSSVLPKRAFPCLWWLKKTFISSRM
KRMMQLNS*QPVLEISRL*TLPVFLTSQDPHLG
M*IPLIRSWCWHSGT*SCPRSGMYWGQIRVCMML
ARERH*CILLCGWDC*G*RGSCCRSQVAAELSV
STTRKGRRL*AWPWSEAITSCTSF*PRRMLENQ
TPGAVYPMKYRMETVL*GIIESWTSIH*PLSLIH
IMNTHFLETVALDQFLNL*TSNSN**KQTSSRW
TVLCP***QHRILPVPQRQMASFFPVHRSPRTL
SDFLLLKRLRALSAAQGALLHRLKVPVICQA*LR
RRIQTVPVGRKIKAWKEKGKRWSQHLLWTLELY
LIKTAAFRACLIVE*RARKAFRPVETEMKKLEQ
NLLECPQTRSP*AVEMLCFRETWSWSQAQPSIPL
EVNWEAFQQQMSVPQTLQGKWNMGS*TQMPLFG
RMCFREGKVQRKDLRTLILAQLEPLTCTSQVSL
WIKSVFQTVPLLPVPWMVTNLLSLHLHLVMKKPP
LKKQQKRKLHEVVRRVLMLQ*IRILW*FQLLQK
TRFQMD*NLILS*QQA*VRQCHPQI*PFLGWKK
M*CHTRTQKQIHLMLKAKRANPHPFVLQLETINF
VQTLHVNRTQ*LLVAIWLQNCVIT*LASPKAPQ
QGNPAHKIHPMPPTVKTHRLIQSPLTL*GIPRN
VRIFVLSKWWITKANEKM*N*INL*QICLRWFHI
HIQLSLKWRKNWCQTRQ*YQTVLSLWQTVQAVN
Q*PRMTHFLLSPPRKKREQQLLNYIQLQIIEMA
QMEIRMSLIRGH*KTGQ*ACPHPPLLQSFSTGWG
IPVSQDLVESMRVPPLQQSQKL*ISRGTLTLPC
KVWVRPLWL*IQF*LKKENFWWFQKALQLRNKI
RIKR*PVPLLRKMLSLQELCRKSREHHLLDKILN
NFMKNQSQLTVPRTKHFS*VIHRVHPLPFLRQK
LNITRKWPHKSHC*LKVGLPRAWCHQEQVWPQS
QGRKPWGQSTTAPLCCHVCCQMGLMGPMLLTAVS
LLLWMLE*RTLNPREKLVPVR*VEM*RWMLQGL
MLYKVWLSPEERIYHTTPKTS*FQTSC*AKRRM
PF*VCQWLYRTKL*LTHRELEPQR*YLLIGRKGS
WREQTTAVPWVTLRKPK*TMKHILSYCSLLPRS
SPQTWSSQPMMMGPQLV*GKSCEPRLQAGKGAL
PLYLAWSLPRTHLCLRGQT**RRLPAV*WMLSSN
KSRPLEHCLLRGRPVTCHCPALSWVLSLKD*RV
LLQKK*VLSHLGRAYQWAVLLRKPRGALQDVLL
EGRSQRRSFYLSRGLSQQQKCQT*KLKMKWILEQ
VQFLKKWL*GA*LLH*R*SKAQ*PRR*TEKTGV
Q*SHALMQHLFWLPSRAQNVRTSWMLDWAESVP
QNKVYLKENLGVILTSFTHPVMTWTASSSQSQRK
SIWPVISPDPVHPPMTRLHWTDILLMAVMCLSP
RF*SQTGQEIGKALMDSTAMGWELRVEKVRVSL
LTQATWRRRRWTVSLKCLQTALS*GAPCALFLPS
GGTAGGLGKMQPAMQK*TTGV*AGAPLVCSTLL
A*VLTLITEVSV*KA*QEELVSETSHPHL*K*A
LQMPKSSDTHSVVRNGLTLWCHFQKRIWSQTREN
IGCLISRYVTDLSSRDLITVHQPFPLH*QNPSH
**QSAILDWTIHGPSTVPSTIPVLI*LRV*QKR
TIISCHIAPPRKILNGRVEQKSVVHSATSRIKCL
AARRAKKRKKKKIRLRRRRKILKTRRKIRRLST
GTLSVPFLLWVPSAVASV*SPSPTKMPILVQIA
VLLSTKAAEKV*PPVQRSK*SSPKGAFRHMTHHH
CPRSL*ETSPHSPRSVLGPQSSWWMKPLPPQYL
PIDDPSRVSRSPKVSPYRTLLELAMMRTCQTPG
NSCLIQQTH*IKSARSMSQQNHLLMRE*VQT*MK
DNYWETLRLSPNSWKQSLGVG**TASF*NSKRK
MWSNGKK*YMS*CRQSFIMSALSRS*VVCTARG
*WRICFLSSRW*KSCSPVWMS*SVSIANSSRGFW
SGRRSLWWIKVKRTFSSRG*GMCL*ISFQVRMQ
NV*RRHMASFVGNITSL*TTSKTFMPRISVFKP
L*RRR*AVQLLEGLEFQSAYCL*LSGLPSTQFYS
KEYCSVPKTMKWSRKI*HSP*AW*RM*LEL*TA
KWQVMKRKCVSMRFIQRQIASQS*G*RVVRCLP
RKI*NGRSLYVMGVCF*RMQQEG*KRFKQFFSLT
F*FSFKKKTRSTSLHHWTRSQQ*SL*RS*L*EK
WHMRRKVYS*SAWG*QIQRW*KSMPAPKRNETA
GFRSFRTQSTP*TEMKMKEFLVRMRKKRKCWTPE
PEN*KNNFTRRTKKSYSCWKRRR*FSGTWLSAA
PLSQRIAPQHIALEFSSAPTQKRLSKEDL**KV
Q*MRWRSFRVW*VEIWEAHLGRLSAAPLSKMWSV
PFPCPGEQRPLEDLTAIR*MLQKEARRKREMMA
KILGERNQIVA*KRVEMLTWYLCLKETVSRLSR
ALFISTSSSALCRVWCCSRTATLRTRNWC*ARGR
SLAACPARAPSLSRRSSAAWRSSARTWPTCRSS
RPSTSRRSAGASVSGKLVRGSCGSGRPSWPSAR
RRCSRGSRTWKRSGRSSSRRRAHTSMTWSDCVLP
RNSLRGNRSSCAGRQSGSASGRQNGTCVRFPIH
IPS**GSHRSSPVLRSPPRHLHLP*PNQGHWTQ
NFQCPQKGTASLGHTKIRGLFTY*VQPARQTKDQ
KGRARPLRPPLPLPACLG*QSQRKRRRKKRRTK
PAALSPVMVPRQKYQQRVKRSSADPLPLC*GSC
LLILASPPLLLSPRAQVSYTGRPLLLSVQSSWAA
PGPGQ*ATDDIECRVGKEAQTLLRP*FVTAQDS
QVGLALLRITLKVMAS*VQVMVLDTSGIPKG*K
SVSK*GLNLRMPFIWGNTKPNSRCFGLDLCTYMG
TCLHIHTGNARRRPSLHQASGQLSTRAVPGRTR
SPRISAVHPVLLRDWFPSKPIPGTYHPCFACIS
HFILGMTNICETSERRLDVYKRRDVHHLDLGVSG
TKATKQPIVSHSVIRSRRNILVFQHVYPHVLAM
DKVKRPTHHYPCSVTPFDCH*PLRRGHGLLAVF
LSPRRASPRQQLSGPCWVRAHHCQGSASHPGQAE
AVL*S*DSWLRSGFRRRVKPCVAVPASADLERS
WPGRRGCESALLMLGGLGKIGFLQKYM*RSVVE
LYSAPGSRYRWLPAARLCFCFSHRVFIFVHLRLS
PAGVCRTVHGNVAL*GPVHQKGGPGKFCASNVA
FNSCFFAPRKHGAFEHT*KKKNL*LGAY**IAS
WPCRWRYLSFSLFERGLV*NL*PTFVLFIVFVCL
CLFFFKGEPGLAQQSKLSSQYRVKWQPALFTLC
LLKCLEGPDEILKGGGPCPSLPHPASFFNQRMS
SPLFENEETRHL*PTFAFFCHGEYSPFRNRPKAK
TC*FFY*KYVPLQRP*TKS*VSFFHLFVQLQVT
AESVVTFLRSTRGLAVCSGHWLRVPLLGFAGGQ
Y*TCILLLVNVGRVPLFSGFGTIRGWC*WDLLAY
VLFTKTPWMLKLEHVATELDINVRGSLTPRPAV
MFHLLWLFWWSFLKIEISHLPRPHSKRFGQVLV
GQV*NQSSARNSLKPPNFIQEYSLQCSNRTAYQE
LCLHTFVISLPPLEVVLRGICSCPGDLPGMVAA
CAFAHGLDSALVAGSNGLSWFLSHEKGLFFWGD
SD*IPHTVSTPGHHVLHQAKEITCLKLCLSFGGK
MEFLSRAPRFPESSELPGRRLRLLSIPVISVVV
VR*HVHFKCSHRLASFSRQSNVLTVFSS*KMER
VKNMQTATFNLCQYSLYPRESYLGGRILTKVFLE
RYES*LFSPSVSQGNTIQSRPFAHFLPYLLPS*
GLSISREHKVLRPLALFLDVGGEVLVHARVELD
RPCLSRGWDYNLRGQNLIQKLLSTEVLSISSFLF
LGLFFCSQVFPRILVFALELRFTLMMVAQLCPE
DSQAGPGREFRKTVLVNGLQVVTKRVAVR*PQT
LQNDVHPLRFGCPWNVGA*K*PCGWNWGSGCWRS
VCLAFLQQDRLGAQPPMDASQPAPSLSSILRDK
EEGREFGLGFELSFQCSKAFLVNQSLGIYCLLA
RL*NEKCFNAAIKGRRGGGRENKGIFPSTHLI*L
SKD**AMNYFSISLRVKGVQPPTGCVPCHRSE*
PALQPGGTTCAAVRRGFCRKHSPPTPSPA*ASP
TFRHHLRA*AQAMGRAW*VCLWFRLSLWSPVCCC
PHGMRRGGVGIRRRVVGIHRIPLLSLLVCKCSM
DICVLNPIK*KRRVKTQMLYIHL*LCIK*SSFK
L*RFFSVCFLEFCHNILASYFIYLSF*LPASDPC
KVSLSPFKK**ISCEVL
Frame 1
ELKWGK*RSKSFHDVWLSAAAQVTTSTQRKGGFWRQGGEETVGGHFPEQPLPATLL*SLCRRAAAA
VNLSLP*QPECPVQEPYYWSHAARWAVLPCNPSS
QFLLRVYSREDSQALPPSRVPRPPSRASFGACA
DWSCVQGQRGARAAAVKRLCSAETAVPIARLGR
RRFSRLRGSGRLLSFSAAKVKSCPSSARGGAPGA
ARVLGHET*STASSLIW*LCCYSAAC*RGQS*R
*CSVLLGIFGFHPPSLYKYSEGQF*YIGDHCSW
S*LL*NSEGAALCFQRGPSRVCGG*RRLSFRPG*
SV*CSSIPSNQCWKSAGFELYPFS*PVRTPIWG
CEFP**EVGAGIQAPEAAHGVECIGDRSEFA*C
WPARDIDAFCCAAGTAEVDVVPVAEARWPRSSQY
PQPGRGDACELGLGARLSQAAPASNRGECWRTR
LLEQFIL*NTVWRLFCEASSRVGHLYINL*V*F
TS*TPISWRRLHWTNF*TYEHPTATNENKPQADG
QSYALNDDSTGSFQCPRDRWPVSSLCTGAHGPS
ATFFF*RD*EHSVLPREPCCTD*KSL*FVKHS*
GGEYRPFL*EEK*RRGKKRGRGGASTYCGLWNCI
*SRQLPSELA*LWSKGHGRPFVLWKQK*RNWNK
IFWNAHRPGVPEQWRCCASERLGHGARHSPVFL
WR*TGRHFNNKCQYPRHCRGNGTWAHEPRCHCLE
ECASGRGKYKGKI*EL*YWHSWSL*RARHK*AC
G*NQCSKLCPCCQFPGW*QTC*VFTCI***RNL
H*KNSRNGNFTKS*GEC*CSSRSEFCGDSSCCKR
QDFRWIRTLYSLSSRHR*GNVTLRFSPSWAGRR
CNATPELRNKFISCSKPKGQILTHLFYNWRR*T
LCRLCMSTEHSDF*WRFGCKTV**HS*RVRKHHS
KATQLTRSTRCLPL*RPTGSYSHL*PCKGYPGT
CGFLSFQSGG*QRPTKRCETR*TFNKYA*GGFT
STSSCP*NGERTGARPGSNIRQYFLSGKQSRQ*I
SNQG*RTFFCPLPERKGNSNS*TTYSYRL*RWP
RWKFE*A*YAATRRQGSRPVHILHCCRASARDG
EYQSHRTWWRA*GSRPSSNPRSSEYQGEH*LFPA
KCG*GHFGFRFSFD*RRKTSGGFRKLCSSGTR*
G*SGDLFLY*GKCSLFRNFAGRAENTTSWTRYS
TIS*KINLS*LCQGQSTSAK*FTGCILCLS*GRN
*T*QGSGPTSLTADSRWGCPEPGATRSKSGHRV
KAGSLGGRAQQLRSVAMSVARWV*WVRCS*LQS
AFSSGCWSEEHSIPGKN*CL*GEWRCDGGCYRG*
CSTRYG*AQKREYITQHPRHPDSKRLVEPREEC
RSRFASGSTGQSCD*PTGSWNPRDDTS*LGERE
AGGSRPQLYHG*R*GSPNRR*STSCPTAACCQGA
PHRHGALSP**WGPSWCEGSHASPAFRQGKEHS
LSTLHGLCPGRTSA*GGRLDRGGCQPYSGCCHR
TSQGRWSTAY*GGGLSHVTVQP*VGSSH*RTREC
FYRKSEYFPTWGEPTNGQYS*GSHGEPCRMFCW
KGGAREDHFTCPGA*ASSRNARRES*R*SGF*S
KFNF*RSGCREHSCYTEDEARPNDPGDKPRKLVY
NRAMP*CSISSGFQAEPRM*ELPGCWTGQRVYL
KTRCT*KRIWE*F*PLSLTQ**HGQHHLPKARG
RAFGL*YHRIQFIHR*HGFTGPTFFSWQ*CVSLP
DFKAKQVKRSAKP*WILQPWDGS*GSRK*E*AC
*PRRRGGGGDGQYH*SACKLLCPKELHALSFSL
PEAQLGAWEKCSQRCRNEPPEYELVPLWCAVLCW
PEC*L*LQKFQSRRLDRRSWCRKQAILISRSKL
CKCRRAQTPIQW*GTG*LFGVTFRRGSGVRPER
T*DV*SADMSQI*AAGI*LLYISHFLSIDKIHLI
NDNQPSWIGQFTALPQYLPQYQC*SD*EYNRRE
L*FPAT*PLQERF*MEEWNKSQSYIQLHQE*NV
*QQEEQRKGKRKR*D*GEGERF*RQGER*EDCQR
AHFQFHSCCGSHQL*PVYEALHQQRCLYLCKLQ
CFCPQRLPRKSSLLCKGQNEAAQREPSGT*HII
TAHGHYEKQALTAQGASSVRSPPGG*NRYHPNIC
Q*TIPAECLALQKCLHTEHYWSWQ**EHVKHLE
IPVSFNRLTK*NQQGQ*VNRITY**GSRYRHE*
RTTTGRL*D*VQTAGSRVLESDNRQQVSKTAKER
CGQTARSNI*VDADRVSSCPHSQDHEWCVQPGD
DGGSAF*AADGRKAVPLFG*ADQYP*PILPEDS
GAEEGVSGG*K*KELSHQEDRGCACKSVFR*ECR
TFKEDIWQVLWAT*PVCKLLQRPLCQG*AFSSL
CKEEDEQFSC*KAWNSRVHIACNSADYQVPSFI
PKNIAVYQRQ*SGAGRSSTVLEPGEGCDWSCRQQ
SGKL*KESASQ*DLYKDR*QVNHEDEEWSDVCQ
GRFETEEACT*WECVSEECSRKVERGSSSSSH*
HFSFPSRKRPEVHLCIIGPEVNSDLFKEADCERS
GT*GERFIPDQHGDDRSRDGRSPCQLQRGTKQL
DSDHSGHNQHPEQR*R*RNS**E*GRKENVGHQ
SPRIKRTTSPEGPKNPTLVGREGDDFPGHG*VQH
PSPRGLLPNT*P*SSLPLQHRRGSQRRTFNEKC
NK*GGDPSGFGEWKSGRHTWADCQQPH*ARCGR
SRFPAPESRDLWRI*QPSDECFKRRREGRGR*WP
RS*ENGIR*WPKKGWKC*PGIYA*KKQ*AGCPE
RCSSLRAPQRSAGCGAAAGQLH*GPETGAEREG
AHSQLVPPELPH*AGEAAQPGEAAPGPGQPAEAA
GPVPRGEAQARA*VGSS*EGAAGAGGPPGPARG
GGAAGAAGPGKGAGGAPAEEGHIPV*PGATACC
PETA*EGTGAAAPGGRAAQPAADRTGPVSGFPST
YQADEDPIVLPQS*GAPLAICTFHSQIRVIGLR
TFSVPKKEQHLSDTQR*GAFSHTEFNQPDKQRT
RRAEPGPCVHLCLYPPVWVNKAKGKEGEKKEEQN
QPLSAR*WSRVRSISRG*RDLLLTLFLSAEAAA
S*SWPAHLSCCPRVHKSLTLDAHCSSASSPPGR
PQVLDNKQQMILSVGWGRRPRLCFGHDL*LPRTL
RLGWPYSGLH*K*WPRKYR*WFWTRQEFLKAER
VYPSKV*TSECLLFGGTQNQTADVLDLICVRTW
GPVCIYTRGMPEEGPVCTRRLVNLAQGQCLDGPG
APAYQQFTQYSSETGFPLNPSRAHTTRVLHVFL
ISF*G*QTFVKPVREGLMCIKDVMCTTSISVFQ
ALKQQNNP*YLILSSDPEEISWFSSMFTHMFWPW
IK*RGLLTIIPAA*HLLIVTDHSEGATASWLCS
*APVVPLPDSSCLALAG*GHTTARGQPRTQARQ
KLCSEARTAG*EVGSGEG*SHV*QFLPVQIWRGA
GPEGVVVKAPFLC*EALAKLDFFKNTCKGLLLN
CTLPLEADTDGCLLLGFAFAFPTVFSSLFT*GF
PQLVCAGQFMVMLPSEAPYTRREALENFVLPTWP
SILAFLPLGSMGLLSTLKKRKICNLVLIDELQA
GLADGDIYLSVYLKEVWFKICSLHLFYLLYLCV
CVCFFLRVSQV*PNSLNYPVNTE*SGSQHCSLCV
F*SALKAQMKF*REGVHVLPSPTPPHSLIKGCL
LPCLRMKKLATSDLPLPFSVMENTHPSETDQRP
KPADFSIENMSPCKDPKQKVKFLSFTYLYNSKLQ
LNLS*LS*DLPGAWLSVLGTGSEFPSWDLQEGS
TEPAFFSL*M*AGCPCSPGLEQYEVGADGIYLR
TCSSQKHRGC*S*STSPQSLTSMLEGLLLPAQL*
CFICFGCFGGLF*K*RFHICPDPTQNDLVRFWL
DKFKIKVVPGIPSNHPTSSRNTVCSAATEPLTK
NCAYIPLSSLFPPWKLSSGGFVPVLGIYLGWWLP
VLLLMALTVL*LLDLMACLGFYHMRRGCFFGVT
RTEFPILFPRRDTMFSIKLKKSRA*NCA*VLGE
RWSSYPEPPDFQNRVSFLEGDCVFSQFQSSQSLS
LGDMCTLNALIGWLHFQDNQMY*LCFLLRKWRG
LKTCKLPLSTFASIPSTPVRAIWGEESLPRFFW
KGTNLNFFPLLCLRVILFRVAPLLIFSRICYLPE
ASVLVVSTKF*DLWRCFLMWEGRC*CMQGLN*I
DPALVEGGTITLEART*SRSCCPQKCFLFHHFC
F*GSFSVARSSQGF*YLHWS*GLL**WWPSCAQR
TARQALGGSLERQSW*MGFKWSQRGWL*GDPRH
CRTMCTLCVLDVLGMWEPRNNPVDGIGAAAAGD
LCALPSFSRTV*VRSHLWMRPSQPRRSRPSSETK
KRAGSLGLVLNFPFNVAKHS*LTRALESTACWP
GFKMKSVLMLP*KGGGGEEGKIKASFQVLI*FN
CQKIDRP*ITSPSH*GLKACNPPLAVSPATEVSD
LPYNQVGPPVLQSGGASAGSTHPPHLPRPELPL
PFVTT*GHEHRPWGVPGESACGSGLACGLLCAA
ARMGCAGEAWGSAGGWLGYTGYLCSHCLFANALW
TFVC*ILLNKKDGLKPRCCIFICNYV*SEAVLN
CKDFFQCVFSNFATTYWLRILFIFLSSYQLQTL
VKSPSALSKNNKFPVKFW
Frame 2
S*SGGNRGVNHFTMCG*VLQLR*PPVHRGRAVSGDRAERRPWVGISQSSLCQPPYFDHFAAEQQRR
STSASLSNLSAPSRSLTIGLMQRDGQFCRAIPA
RSSCSACTHGRTRRRYRLPACPAHPPERLSAHAR
TGAVCRASAEPEQPR*SACALPRLPCPLLASVA
AALAASGGAAAYCLSPRRR*RVVPARPAGEPRE
PHVSWVMKLNPQQAPLYGDCVVTVLLAEEDKAED
DVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPG
HDCCETVKVQLCASKEGLPVFVVAEEDFHFVQD
EAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGD
VNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDA
GPRETLMHFAVRLGLLRLTWFLLQKPGGRGALS
IHNQEGATPVSLALERGYHKLHQLLTEENAGEPD
SWSSLSYEIPYGDCSVRHHRELDIYTLTSESDS
HHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQM
DSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQ
RLSSSEETESTQCCPGSPVAQTESPCDLSSIVE
EENTDRSCRKKNKGVERKGEEVEPAPIVDSGTV
SDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTK
SSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSS
GGELGGISTTNVSTPDTAGEMEHGLMNPDATVW
KNVLQGGESTKERFENSNIGTAGASDVHVTSKPV
DKISVPNCAPAASSLDGNKPAESSLAFSNEETS
TEKTAETETSRSREESADAPVDQNSVVIPAAAK
DKISDGLEPYTLLAAGIGEAMSPSDLALLGLEED
VMPHQNSETNSSHAQSQKGKSSPICSTTGDDKL
CADSACQQNTVTSSGDLVAKLCDNIVSESESTT
ARQPSSQDPPDASHCEDPQAHTVTSDPVRDTQER
ADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSH
PHPVVPKMEKELVPDQAVISDSTFSLANSPGSE
SVTKDDALSFVPSQKEKGTATPELHTATDYRDGP
DGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMG
NTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSL
QSVGKATLALDSVLTEEGKLLVVSESSAAQEQDK
DKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQ
QFHEKSISADCAKDKALQLSNSPGASSAFLKAE
TEHNKEVAPQVSLLTQGGAAQSLVPPGASLATES
RQEALGAEHNSSALLPCLLPDGSDGSDALNCSQ
PSPLDVGVKNTQSQGKTSACEVSGDVTVDVTGV
NALQGMAEPRRENISHNTQDILIPNVLLSQEKNA
VLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGK
LEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKE
LPTDMELSAHDDGAPAGVREVMRAPPSGRERSTP
SLPCMVSAQDAPLPKGADLIEEAASRIVDAVIE
QVKAAGALLTEGEACHMSLSSPELGPLTKGLES
AFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAG
REEPEKIILPVQGPEPAAEMPDVKAEDEVDFRA
SSISEEVAVGSIAATLKMKQGPMTQAINRENWC
TIEPCPDAASLLASKQSPECENFLDVGLGRECTS
KQGVLKRESGSDSDLFHSPSDDMDSIIFPKPEE
EHLACDITGSSSSTDDTASLDRHSSHGSDVSLS
QILKPNRSRDRQSLDGFYSHGMGAEGRESESEPA
DPGDVEEEEMDSITEVPANCSVLRSSMRSLSPF
RRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSA
GLSADFNYRSFSLEGLTGGAGVGNKPSSSLEVSS
ANAEELRHPFSGEERVDSLVSLSEEDLESDQRE
HRMFDQQICHRSKQQGFNYCTSAISSPLTKSIS
LMTISHPGLDNSRPFHSTFHNTSANLTESITEEN
YNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMS
SSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVN
GHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCS
AFVHKGCRESLASCAKVKMKQPKGSLQAHDTSS
LPTVIMRNKPSQPKERPRSAVLLVDETATTPIF
ANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWK
FLSHSTDSLNKISKVNESTESLTDEGVGTDMNE
GQLLGDFEIESKQLEAESWSRIIDSKFLKQQKK
DVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGM
MADLLFEQQMVEKLFPCLDELISIHSQFFQRIL
ERKKESLVDKSEKNFLIKRIGDVLVNQFSGENA
ERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAF
VKKKMSSSVVRRLGIPECILLVTQRITKYPVLF
QRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDS
KVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAK
EDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTD
ILVFLQEKDQKYIFASLDQKSTVISLKKLIVRE
VAHEEKGLFLISMGMTDPEMVEVHASSKEERNSW
IQIIQDTINTLNRDEDEGIPSENEEEKKMLDTR
ARELKEQLHQKDQKILLLLEEKEMIFRDMAECS
TPLPEDCSPTHSPRVLFRSNTEEALKGGPLMKSA
INEVEILQGLVSGNLGGTLGPTVSSPIEQDVVG
PVSLPRRAETFGGFDSHQMNASKGGEKEEGDDG
QDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQS
VVHLYELLSALQGVVLQQDSYIEDQKLVLSERA
LTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQ
QAQYLEEKRRREREWEARERELREREALLAQREE
EVQQGQQDLEKEREELQQKKGTYQYDLERLRAA
QKQLEREQEQLRREAERLSQRQTERDLCQVSHP
HTKLMRIPSFFPSPEEPPSPSAPSIAKSGSLDSE
LSVSPKRNSISRTHKDKGPFHILSSTSQTNKGP
EGQSQAPASTSASTRLFGLTKPKEKKEKKKKNK
TSRSQPGDGPASEVSAEGEEIFC*PSSSLLRQLP
PDPGQPTSPAVPACTSLLHWTPTAPQRPVLLGG
PRSWTISNR*Y*VSGGEGGPDSASAMICDCPGL
SGWAGPTQDYTESNGLVSTGDGFGHVRNS*RLKE
CIQVRSEPPNAFYLGEHKTKQQMFWT*SVYVHG
DLSAYTHGECQKKAQSAPGVWST*HKGSAWTDP
EPPHISSSPSTPQRLVSL*THPGHIPPVFCMYFS
FHFRDDKHL*NQ*EKA*CV*KT*CAPPRSRCFR
H*SNKTTHSISFCHQIQKKYPGFPACLPTCFGH
G*SEEAYSPLSLQRDTF*LSLTTQKGPRPPGCVP
EPPSCLSQTAAVWPLLGEGTPLPGVSLAPRPGR
SCALKLGQLAEKWVQAKGEAMCSSSCQCRSGEE
LARKAWL*KRPSYVRRPWQNWISSKIHVKVCC*I
VLCPWKQIQMAACCSALLLLFPPCFHLCSLEAF
PSWCVQDSSW*CCPLRPRTPEGRPWKILCFQRG
LQFLLFCPSEAWGF*AHLKKEKSVTWCLLMNCKL
ALQMEIFIFQFI*KRSGLKFVAYICFIYCICVF
VFVFF*G*ARSSPTV*TIQSIPSEVAASTVHSV
SFEVP*RPR*NFKGRGSMSFPPPPRLIL*SKDVF
SLV*E*RNSPPLTYLCLFLSWRILTLQKQTKGQ
NLLIFLLKICPLAKTLNKKLSFFLSPICTTPSY
S*ICRDFPEIYPGLGCLFWALAPSSPPGICRRAV
LNLHSSPCKCRPGAPVLRVWNNTRLVLMGFTCV
RALHKNTVDAEVRARRHRA*HQC*RVSYSPPSC
DVSSALVVLVVFFKNRDFTSAQTPLKTIWSGSGW
TSLKSK*CPEFPQTTQLHPGIQSAVQQQNRLPR
TVLTYLCHLSSPLGSCPQGDLFLSWGFTWDGGC
LCFCSWP*QCSSCWI*WPVLVSIT*EGVVFLG*L
GLNSPYCFHAGTPCSPSS*RNHVPETVLKFWGK
DGVPIQSPQISRIE*ASWKETASSLNSSHLSRC
R*VTCAL*MLSSVGFIFKTIKCIDCVFFLENGEG
*KHANCHFQPLPVFPLPP*ELSGGKNPYQGFFG
KVRILTFFPFCVSG*YYSESPLCSFSPVFVTFL
RPQY*S*AQSFETFGVVS*CGRGGVSACKG*TR*
TLP**RVGL*P*RPELDPEVAVHRSAFYFIIFV
SRALFL*PGLPKDFSICIGVEVYSNDGGPAVPR
GQPGRPWEGV*KDSPGEWASSGHKEGGCEVTPDT
AERCAPSAFWMSLECGSLEITLWMELGQRLLEI
CVPCLPSAGPSRCAATYGCVPASPVALVHPQRQ
RRGQGVWAWF*TFLSM*QSIPS*PEPWNLLPAGQ
ALK*KVF*CCHKREAGGRKGK*RHLSKYSSNLI
VKRLIGHELLLHLTKG*RRATPHWLCPLPPK*V
TCPTTRWDHLCCSPEGLLQEALTPHTFPGLSFPY
LSSPPEGMSTGHGACLVSLPVVQA*PVVSCVLL
PAWDAQGRRGDPQEGGWDTPDTSALIACLQMLY
GHLCAKSY*IKKTG*NPDAVYSFVIMYKVKQF*T
VKIFFSVFSRILPQHTGFVFYLSFFLVTSFRPL
*SLPQPFQKIINFL*SS
Sequence AKAP13.fAug05
GTTCCATCTGTGGGTAACCATGTTCCGAGGCAGCAAAGAGAAACCGCTATTGCTCCGTGGAAATAAACTATCTGAATAAAACTTCTTAACGGGGGTTGAGGCTGAAGCTGAAACGGGAGTCGGACACGATCTTGGCTCCTGAAGTCTTTAAAGGTCAGTTTGATGCACACTTCTATACCACCACCTGTTACCAGCTGTAG
ACAGAAGACCTATCTCCATGCTTGCCCCTAGGCTTTTGTAGAAATGCCAGACGTGAAAGCTGAAGATGAAGTGGATTTTAGAGCAAGTTCAATTTCTGAA
GAAGTGGCTGTAGGGAGCATAGCTGCTACACTGAAGATGAAGCAAGGCCCAATGACCCAGGCGATAAACCGAGAAAACTGGTGTACAATAGAGCCATGCC
CTGATGCAGCATCTCTTCTGGCTTCCAAGCAGAGCCCAGAATGTGAGAACTTCCTGGATGTTGGACTGGGCAGAGAGTGTACCTCAAAACAAGGTGTACT
TAAAAGAGAATCTGGGAGTGATTCTGACCTCTTTCACTCACCCAGTGATGACATGGACAGCATCATCTTCCCAAAGCCAGAGGAAGAGCATTTGGCCTGT
GATATCACCGGATCCAGTTCATCCACCGATGACACGGCTTCACTGGACCGACATTCTTCTCATGGCAGTGATGTGTCTCTCTCCCAGATTTTAAAGCCAA
ACAGGTCAAGAGATCGGCAAAGCCTTGATGGATTCTACAGCCATGGGATGGGAGCTGAGGGTCGAGAAAGTGAGAGTGAGCCTGCTGACCCAGGCGACGT
GGAGGAGGAGGAGATGGACAGTATCACTGAAGTGCCTGCAAACTGCTCTGTCCTAAGGAGCTCCATGCGCTCTCTTTCTCCCTTCCGGAGGCACAGCTGG
GGGCCTGGGAAAAATGCAGCCAGCGATGCAGAAATGAACCACCGGAGTTCAATGCGAGTTCTTGGGGATGTTGTCAGGAGACCTCCCATTCATAGGAGAA
GTATGAGCTGGTGCCCCTCTGGTGTGCAGTACTCTGCTGGCCTGAGTGCTGACTTTAATTACAGAAGTTTCAGTCTAGAAGGCTTGACAGGAGGAGCTGG
TGTCGGAAACAAGCCATCCTCATCTCTAGAAGTAAGCTCTGCAAATGCCGAAGAGCTCAGACACCCATTCAGTGGTGAGGAACGGGTTGACTCTTTGGTG
TCACTTTCAGAAGAGGATCTGGAGTCAGACCAGAGAGAACATAGGATGTTTGATCAGCAGATATGTCACAGATCTAAGCAGCAGGGATTTAATTACTGTA
CATCAGCCATTTCCTCTCCATTGACAAAATCCATCTCATTAATGACAATCAGCCATCCTGGATTGGACAATTCACGGCCCTTCCACAGTACCTTCCACAA
TACCAGTGCTAATCTGACTGAGAGTATAACAGAAGAGAACTATAATTTCCTGCCACATAGCCCCTCCAAGAAAGATTCTGAATGGAAGAGTGGAACAAAA
GTCAGTCGTACATTCAGCTACATCAAGAATAAAATGTCTAGCAGCAAGAAGAGCAAAGTGAGTATCACTGTGGGCATTGCTTGTGATCACCTCAGTAGGA
TCCTGTCACAGCCTGCATTCACACCAAAACTGGTTAAATCATGGGGACATAAATGGAAATAAATTCAGGATTACTCTCCGAAATCGCCTAATATTTAAAG
GAAAATAATAAGAAGAAAAATAGCAAGAAGTGGAACTACCAGTTACTGAGTTTTCACTATATGCTAAGTGCTTTCCATATATTATTTAACCCTTTCAACA
ACCCTGTCAGGTAGGTGTTATCTCTCTTTTCTAAAAGTGATGTACCTTACCGAGGATACTCCTCTAATGTGAAGAAGTAGTTCAAACCAGATCTCTTTGG
TTTCAAATCCCATACTCTTAAACCACAGTGCTTAAATCTGTAATATCAGTTTAAATGCAACAGAAGGATTTTATGCAAAGATCAAAGGATTGAAAATATT
TATATTTGGCTTTAGAGGGAAGGATTATCCCACAGAAGATTACAAGAACTTTTAAGACTAATATGATTTCTTAGATCTATTTCTAATTAGGAGCATTTGG
AATATATTCTCTTAGTGATTAAGAGATTAAATAAATGTTTAAACCGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTGTGTGTGTGTGTGTAAGGCTCCA
CTGTATCACCCAGGCTGGAGCACAGTGGCGTGACCATAGCTCACTGCAGTCTTGAACTGCCAGGCTTAAGCAGTTTCCTGCCTCGCACCGTAGCCTCCCG
AGTAGCCAGGGCTACAGTCATGTTGTGCCATCGTGCTGAGCTATGTTTAAATTTGTTTGTAAAGATGAAGTCTTGCTGTTGTGTCTAGGCCGGTCTAATG
CCTTACCTCAAACACTCTTCTCGCTGCAGGCTTCCGAAGCCCTGGGTGTGATCCACCGTGCCCAGCCTAAAGTAACATTTTTTATCTAATTATTTTTCAC
ATGCTCATTATGGAAATCTTCAAAATCTAAAAGTAAAAGAATGAAAATCTCCTGGAATAACCCCGCTTAGAGATAACTACACTTAATGTTTTGGTTTATA
TATTTCTAATCTTTTTTAAAAATGTATTTTCAAAAGAAAGGGAGAAAAGAAGTTCACTTTCTTATACTGATTCCCAGTGCTAAACCAAAACTGATTCCAT
TTCAAGTCCGTGGGGAAAAACTTTTCGCCTCTCACACCCTGTTCATCTACCCACAACACCCTCTAACAAAATAAAGACATAAGTAAATAAAAATTTGAAA
TCAGTTAAGGAACTCTTGCAAGGAATCACTGTGTGTGTGTGTGTGTGTGTATGTGTGTGTGTGCACGTGCATGCATGTGTGTGTGTGTGTGGTATATACA
TGTACATACAGATATATACACACGTAGATACATGCATATTTAGAAGTAAGGGAATAAACAAACATTGAATTCAAGAATATTGTCATAAAAGGGCATTGCC
TCCTCCCTCACAAAACAAGGTGCACTAAGCTTCTCAAGCCCTCACTTCAGTGGGCTGATGGAAATATAGCCAAAGTATTTTACCATGTTTTGTAAGATCT
CTTGGTTTAGCAAATACATTCAAAGAAATTTTTCCACCAAACGTGCCACAAGAATTGTGTTTTCATTTCTCCTGTGCAAGTACAGAATGGAGAGAAAGTA
GGCAATCAGGGAGAGATGCAAAGAGTCTAGCAAATTATTTCTAGCATAATCACACATTTAACTTCAGACTCAGCCTTGTTTTATAATTCCAAAAAAAAAA
AAAATGAAGGTCAAAGAATACTGCTTTACCAGTATTCTACGTATTTACATATTGGCAGCCAGGCTTAAAATAGAGCCTTACCTTTTTTACTTACCACTGC
CGGCTTGGATACTAGTTGG
- AKAP13-F1 (forward primer)
- AKAP13-R1 (reverse primer)
- Single exon skipping
Frame 0
VPSVGNHVPRQQRETAIAPWK*TI*IKLLNGG*G*S*NGSRTRSWLLKSLKVSLMHTSIPPPVTSCR
QKTYLHACP*AFVEMPDVKAEDEVDFRASSISE
EVAVGSIAATLKMKQGPMTQAINRENWCTIEPC
PDAASLLASKQSPECENFLDVGLGRECTSKQGVL
KRESGSDSDLFHSPSDDMDSIIFPKPEEEHLAC
DITGSSSSTDDTASLDRHSSHGSDVSLSQILKP
NRSRDRQSLDGFYSHGMGAEGRESESEPADPGDV
EEEEMDSITEVPANCSVLRSSMRSLSPFRRHSW
GPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRR
SMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAG
VGNKPSSSLEVSSANAEELRHPFSGEERVDSLV
SLSEEDLESDQREHRMFDQQICHRSKQQGFNYC
TSAISSPLTKSISLMTISHPGLDNSRPFHSTFHN
TSANLTESITEENYNFLPHSPSKKDSEWKSGTK
VSRTFSYIKNKMSSSKKSKVSITVGIACDHLSR
ILSQPAFTPKLVKSWGHKWK*IQDYSPKSPNI*R
KIIRRKIARSGTTSY*VFTIC*VLSIYYLTLST
TLSGRCYLSFLKVMYLTEDTPLM*RSSSNQISL
VSNPILLNHSA*ICNISLNATEGFYAKIKGLKIF
IFGFRGKDYPTEDYKNF*D*YDFLDLFLIRSIW
NIFS**LRD*INV*TVCVCVCVCVSVCVCV*GS
TVSPRLEHSGVTIAHCSLELPGLSSFLPRTVASR
VARATVMLCHRAELCLNLFVKMKSCCCV*AGLM
PYLKHSSRCRLPKPWV*STVPSLK*HFLSNYFS
HAHYGNLQNLKVKE*KSPGITPLRDNYT*CFGLY
ISNLF*KCIFKRKGEKKFTFLY*FPVLNQN*FH
FKSVGKNFSPLTPCSSTHNTL*QNKDISK*KFE
IS*GTLARNHCVCVCVCMCVCARACMCVCVWYIH
VHTDIYTRRYMHI*K*GNKQTLNSRILS*KGIA
SSLTKQGALSFSSPHFSGLMEI*PKYFTMFCKI
SWFSKYIQRNFSTKRATRIVFSFLLCKYRMERK*
AIRERCKESSKLFLA*SHI*LQTQPCFIIPKKK
KMKVKEYCFTSILRIYILAARLKIEPYLFYLPL
PAWILV
Frame 1
FHLWVTMFRGSKEKPLLLRGNKLSE*NFLTGVEAEAETGVGHDLGS*SL*RSV*CTLLYHHLLPAV
DRRPISMLAPRLL*KCQT*KLKMKWILEQVQFLK
KWL*GA*LLH*R*SKAQ*PRR*TEKTGVQ*SHA
LMQHLFWLPSRAQNVRTSWMLDWAESVPQNKVY
LKENLGVILTSFTHPVMTWTASSSQSQRKSIWPV
ISPDPVHPPMTRLHWTDILLMAVMCLSPRF*SQ
TGQEIGKALMDSTAMGWELRVEKVRVSLLTQAT
WRRRRWTVSLKCLQTALS*GAPCALFLPSGGTAG
GLGKMQPAMQK*TTGVQCEFLGMLSGDLPFIGE
V*AGAPLVCSTLLA*VLTLITEVSV*KA*QEEL
VSETSHPHL*K*ALQMPKSSDTHSVVRNGLTLWC
HFQKRIWSQTRENIGCLISRYVTDLSSRDLITV
HQPFPLH*QNPSH**QSAILDWTIHGPSTVPST
IPVLI*LRV*QKRTIISCHIAPPRKILNGRVEQK
SVVHSATSRIKCLAARRAK*VSLWALLVITSVG
SCHSLHSHQNWLNHGDINGNKFRITLRNRLIFK
GK**EEK*QEVELPVTEFSLYAKCFPYII*PFQQ
PCQVGVISLF*K*CTLPRILL*CEEVVQTRSLW
FQIPYS*TTVLKSVISV*MQQKDFMQRSKD*KY
LYLALEGRIIPQKITRTFKTNMIS*IYF*LGAFG
IYSLSD*EIK*MFKPCVCVCVCVCLCVCVCKAP
LYHPGWSTVA*P*LTAVLNCQA*AVSCLAP*PP
E*PGLQSCCAIVLSYV*ICL*R*SLAVVSRPV*C
LTSNTLLAAGFRSPGCDPPCPA*SNIFYLIIFH
MLIMEIFKI*K*KNENLLE*PRLEITTLNVLVY
IFLIFFKNVFSKEREKRSSLSYTDSQC*TKTDSI
SSPWGKTFRLSHPVHLPTTPSNKIKT*VNKNLK
SVKELLQGITVCVCVCVCVCVHVHACVCVCGIY
MYIQIYTHVDTCIFRSKGINKH*IQEYCHKRALP
PPSQNKVH*ASQALTSVG*WKYSQSILPCFVRS
LGLANTFKEIFPPNVPQELCFHFSCASTEWRES
RQSGRDAKSLANYF*HNHTFNFRLSLVL*FQKKK
K*RSKNTALPVFYVFTYWQPGLK*SLTFFTYHC
RLGY*L
Frame 2
SICG*PCSEAAKRNRYCSVEINYLNKTS*RGLRLKLKRESDTILAPEVFKGQFDAHFYTTTCYQL*
TEDLSPCLPLGFCRNARRES*R*SGF*SKFNF*
RSGCREHSCYTEDEARPNDPGDKPRKLVYNRAMP
*CSISSGFQAEPRM*ELPGCWTGQRVYLKTRCT
*KRIWE*F*PLSLTQ**HGQHHLPKARGRAFGL
*YHRIQFIHR*HGFTGPTFFSWQ*CVSLPDFKAK
QVKRSAKP*WILQPWDGS*GSRK*E*AC*PRRR
GGGGDGQYH*SACKLLCPKELHALSFSLPEAQL
GAWEKCSQRCRNEPPEFNASSWGCCQETSHS*EK
YELVPLWCAVLCWPEC*L*LQKFQSRRLDRRSW
CRKQAILISRSKLCKCRRAQTPIQW*GTG*LFG
VTFRRGSGVRPERT*DV*SADMSQI*AAGI*LLY
ISHFLSIDKIHLINDNQPSWIGQFTALPQYLPQ
YQC*SD*EYNRREL*FPAT*PLQERF*MEEWNK
SQSYIQLHQE*NV*QQEEQSEYHCGHCL*SPQ*D
PVTACIHTKTG*IMGT*MEINSGLLSEIA*YLK
ENNKKKNSKKWNYQLLSFHYMLSAFHILFNPFN
NPVR*VLSLFSKSDVPYRGYSSNVKK*FKPDLFG
FKSHTLKPQCLNL*YQFKCNRRILCKDQRIENI
YIWL*REGLSHRRLQELLRLI*FLRSISN*EHL
EYILLVIKRLNKCLNRVCVCVCVCVCVCVCVRLH
CITQAGAQWRDHSSLQS*TARLKQFPASHRSLP
SSQGYSHVVPSC*AMFKFVCKDEVLLLCLGRSN
ALPQTLFSLQASEALGVIHRAQPKVTFFI*LFFT
CSLWKSSKSKSKRMKISWNNPA*R*LHLMFWFI
YF*SFLKMYFQKKGRKEVHFLILIPSAKPKLIP
FQVRGEKLFASHTLFIYPQHPLTK*RHK*IKI*N
QLRNSCKESLCVCVCVYVCVCTCMHVCVCVVYT
CTYRYIHT*IHAYLEVRE*TNIEFKNIVIKGHC
LLPHKTRCTKLLKPSLQWADGNIAKVFYHVL*DL
LV*QIHSKKFFHQTCHKNCVFISPVQVQNGEKV
GNQGEMQRV*QIISSIITHLTSDSALFYNSKKK
KNEGQRILLYQYSTYLHIGSQA*NRALPFLLTTA
GLDTSW
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